{"generated":"2026-09-12","source":"ClinicalTrials.gov API v2 (with SCI-specific tagging from scitrials.org)","count":2167,"treatments":["Brain Machine Interface (BMI)","Brain Stimulation","Devices","Drugs","Electrical Stimulation","Epidural Stimulation","Exoskeleton","Functional Electrical Stimulation (FES)","Intermittent Hypoxia","Neuromuscular Electrical Stimulation (NMES)","Nutrition","Observational","Rehabilitation","Safety","Stem Cells","Surgical Procedure","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"outcomes":["Arm Movement","Bladder Function","Blood Pressure","Bone Strength","Bowel Function","Breathing Function","Hand Movement","Leg Movement","Mental Health","Motor Function","Pain Management","Plasticity","Pressure Sores","Quality of Life","Regeneration","Sensory Function","Sexual Function","Spasticity","Temperature Control","Trunk Control","Walking Function"],"states":["Alabama","Arizona","Arkansas","California","Colorado","Connecticut","Delaware","District of Columbia","Florida","Georgia","Hawaii","Idaho","Illinois","Indiana","Iowa","Kansas","Kentucky","Louisiana","Maine","Maryland","Massachusetts","Michigan","Minnesota","Mississippi","Missouri","Montana","Nebraska","Nevada","New Jersey","New Mexico","New York","North Carolina","North Dakota","Ohio","Oklahoma","Oregon","Pennsylvania","Rhode Island","South Carolina","South Dakota","Tennessee","Texas","Utah","Vermont","Virginia","Washington","West Virginia","Wisconsin"],"trials":[{"n":"NCT05403606","t":"\"Guarantee Assessment in Skin Prevention Adapted to Real Life With a Connected Device After a Spinal Cord Injury.\"","d":"The investigators propose to test an embedded device on the seat of the wheelchair of paraplegic or tetraplegic patients (Gaspard), allowing on the one hand the continuous measurement of the pressures of seat, on the other hand a retro-control connected to the cell phone of the participants to inform them on these variables of seat (bad positioning, prolonged supports etc...) This study will be carried out over a long period of time (1 year), in an ergonomic situation of integration in the…","s":"Terminated","tr":["Devices"],"o":["Mental Health","Pain Management","Pressure Sores"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05403606"},{"n":"NCT05244408","t":"\"SCRIBBLE\" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation","d":"Prospective, single center study designed to assess blood biomarkers for classifying injury severity and predict neurologic recovery in traumatic spinal cord injured (SCI) patients. Study will also establish the accuracy of point to care devices for SCI blood biomarkers and support the biospecimen collection for the International Spinal Cord Injury Biobank (ISCIB).","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05244408","su":"https://scitrials.org/trial/NCT05244408"},{"n":"NCT04800523","t":"\"UroMonitor Trial\" in Spinal Cord Injury.","d":"This study aims to determine if a non-functioning UroMonitor device can be safely inserted, monitored, and removed in patients with SCI.","s":"Withdrawn","tr":["Devices"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04800523"},{"n":"NCT05022095","t":"\"Validated Language Transfer of the Spinal Cord Injury-Spasticity Evaluation Tool to German Language\"","d":"To better depict the full range of spasticity after Spinal Cord Injury (SCI) there is a need to take into account the patients perspective and their experiences during daily life. In 2007 the Spinal Cord Injury-Spasticity Evaluation Tool (SCI-SET) was created and validated. This specific questionnaire addresses the influence of spasticity on the daily life of SCI patients and takes into account negative as well as positive effects of spasticity to fulfill certain tasks. Until now this…","s":"Completed","tr":["Observational"],"o":["Quality of Life","Spasticity"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05022095"},{"n":"NCT02025179","t":"12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)","d":"The purpose of this study is to determine if a second year of exposure to teriparatide in both subjects that received a year of teriparatide or teriparatide-placebo will result in a greater increase in bone mass density (BMD) compared to that seen in a single year's treatment. This study will also investigate 1) if a second year of teriparatide therapy will increase bone strength in people with chronic spinal cord injury (SCI) who previously received a year of teriparatide or…","s":"Completed","tr":["Devices","Drugs"],"o":["Bone Strength","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02025179"},{"n":"NCT02586649","t":"24hr Effects of Tiotropium Bromide in Tetraplegia","d":"Respiratory complications are the leading cause of death during the initial year after acute SCI, and the third leading cause of death thereafter. Complete or partial loss of respiratory muscle innervations in individuals with cervical and high thoracic injuries leads to inadequate ventilation and inability to effectively clear secretions, often prompting supportive ventilation following initial injury. Development of atelactasis, pneumonias and respiratory failure are the most common…","s":"Completed","tr":["Drugs"],"o":["Breathing Function","Motor Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02586649"},{"n":"NCT06302478","t":"5E Program for Preventing Venous Thromboembolism in Patients With Spinal Cord Disorders","d":"The goal of this quasi-experimental study is to examine the effects of a venous thromboembolism prevention program, or \"5E\" program, on the rates of venous thromboembolism in patients with spinal cord disorders. The main questions it aims to answer are: * Will participants receiving the 5E program have lower rates of venous thromboembolism compared to those receiving the usual care? * Will participants receiving the 5E program have lower scores of venous thromboembolism signs and symptoms…","s":"Unknown","tr":[],"o":["Breathing Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06302478"},{"n":"NCT01184729","t":"6 Minute Propulsion Test Sensitivity to Increased Aerobic Capacity","d":"The goals of this project are to 1)determine the responsiveness of the 6 Minute Push Test (6MPT) and 2) explore the relationship between 6MPT distance and measures of handicap, wheelchair satisfaction, depression, and self-reported avoidance of environmental features.","s":"Completed","tr":["Observational"],"o":["Mental Health"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01184729"},{"n":"NCT01184742","t":"6 Minute Push & 30 Second Sprint Tests Reliability & Relationship to Fitness, Participation, & Environmental Assessments","d":"The purpose of this study is to assess the relationship between physical fitness and wheelchair mobility capacity and 1) participation; 2) self-reported environments barriers; and 3) self-reported avoidance of environmental features.","s":"Completed","tr":["Observational"],"o":["Quality of Life"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01184742"},{"n":"NCT03811301","t":"[BrainConnexion] - Neurodevice Phase I Trial","d":"This study aims to evaluate the safety of a wireless implantable neurodevice microsystem in tetraplegic patients, as well as the efficacy of the electrodes for long-term recording of neural activities and the successful control of an external device.","s":"Unknown","tr":["Brain Stimulation"],"o":[],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03811301","su":"https://scitrials.org/trial/NCT03811301"},{"n":"NCT00407745","t":"A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury","d":"The purpose of this study is to evaluate if pregabalin relieves nerve pain associated with spinal cord injury compared to placebo (pill that contains no active medicine). This study will also evaluate the safety of pregabalin in this patient population.","s":"Completed","tr":["Drugs"],"o":["Mental Health","Pain Management","Sensory Function"],"st":["Arizona","California","Florida","Indiana","Kansas","Michigan","New York","North Carolina","Ohio","Pennsylvania","Texas","West Virginia"],"co":["Chile","China","Colombia","Czechia","Hong Kong","India","Japan","Philippines","Russia","United States"],"lc":67,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00407745"},{"n":"NCT07720882","t":"A Clinical Study of a Fully Implanted, Wireless and Functional BCI for Upper-Limb Functional Replacement in Tetraplegia Due to Spinal Cord Injury: Efficacy and Safety","d":"This prospective, multicenter, single-arm clinical trial will enroll subjects with tetraplegia secondary to spinal cord injury. An implantable brain-computer interface system for compensatory hand motor function will be used to reconstruct upper-limb function, so as to evaluate the safety and clinical efficacy of this device in achieving upper-limb functional replacement.","s":"Recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":["Arm Movement","Motor Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07720882"},{"n":"NCT05167032","t":"A Clinical Trial of Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery in Adults With Spinal Cord Injury","d":"To provide an effective treatment for recovery from paralysis and improved quality of life of veterans, military, and civilians with spinal cord injury/disorder (SCI/D). This is a mechanistic Phase I randomized pilot clinical trial in 16 adults with SCI/D. The investigators will compare the effects of Cognitive Multisensory Rehabilitation (CMR) vs. adaptive fitness on sensorimotor function. Objective 1: Determine if 8 weeks of CMR improves sensory and motor function in adults with SCI/D…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Motor Function","Pain Management","Quality of Life"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05167032"},{"n":"NCT06990412","t":"A Clinical Trial to Evaluate the Safety and Efficacy of an Implantable Wireless Brain-Computer Interface（BCI）System NEO in Patients With Tetraplegia","d":"To evaluate the safety and efficacy of a Minimally Invasive Wireless Implantable Brain-Computer Interface (BCI) System NEO in patients with tetraplegia and to provide a basis for product registration. Through brain-computer interface alternative technology, patients can control the external equipment with brain signals to improve the patient's quality of life.","s":"Completed","tr":["Brain Stimulation"],"o":[],"st":[],"co":["China"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06990412","su":"https://scitrials.org/trial/NCT06990412"},{"n":"NCT00345397","t":"A Colonic Tube to Improve Bowel Function in Spinal Cord Injury","d":"The investigators want to know if placing a tube through the skin and into the colon to flush out the colon is safe and effective in helping spinal cord Veterans with bowel management.","s":"Completed","tr":["Devices"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":["Wisconsin"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00345397"},{"n":"NCT03653390","t":"A Community Wellness Program for Adults Living With Long-term Physical Disability","d":"For people living with long-term physical disabilities, such as spinal cord injury or multiple sclerosis, middle-age (45-64) is a period of great vulnerability for losses in function and participation. There is an urgent need to develop and test interventions that can be delivered through existing community service agencies to help these people maximize their community participation and quality of life. This research will test the efficacy of one such intervention in a community trial and…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03653390"},{"n":"NCT04949971","t":"A Comparative Study of High and Low Tidal Volume in Preventing Hypoxemia in Patients With Mechanical Ventilation After Cervical Spinal Cord Injury","d":"This study in order to best tidal volume mechanical ventilation in patients with cervical spinal cord injury (sci) as the research point, through higher low volume Settings to find the difference of two groups of patients to prevent the incidence of hypoxemia, to find suitable Settings, tidal volume in patients with lower mechanical ventilation in patients with cervical spinal cord injury (sci) the incidence of pulmonary complications, live less intensive care unit (ICU).","s":"Unknown","tr":["Observational"],"o":["Breathing Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04949971"},{"n":"NCT00412308","t":"A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries","d":"The study will compare outcomes between individuals with sub-acute, ventilator-dependent tetraplegia using high (20 cc/kg) vs. low (10 cc/kg) tidal volumes during mechanical ventilator support.","s":"Completed","tr":[],"o":["Breathing Function"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00412308"},{"n":"NCT01477736","t":"A Comparison Study of Oxybutynin and Botulinum Toxin for Neurogenic Detrusor Overactivity","d":"The purpose of this study is to compare the effects of oral oxybutynin and intradetrusor injections of botulinum toxin type A on urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity following spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01477736"},{"n":"NCT06688916","t":"A Comprehensive Assessment of Altered Embodiment in Individuals With Spinal Cord Injury","d":"Spinal cord injury (SCI) occurs when trauma or other factors damage the spinal cord, disrupting the flow of sensory information from the body to the brain. This interruption can interfere with embodiment-the body awareness and physical sensations processed by the brain-sometimes leading to a phenomenon called disembodiment. For people with SCI, disembodiment may appear as unusual body sensations, like feeling that a limb is in a different position than it actually is. Such changes in body…","s":"Recruiting","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06688916","su":"https://scitrials.org/trial/NCT06688916"},{"n":"NCT00426842","t":"A Dose Response Trial Using 5 and 10 Mg of Midodrine Hydrochloride","d":"With upright postures, there is an immediate redistribution of blood to the dependent circulation; venous return and central venous filling pressure are reduced, resulting in diminution of cardiac output and blood pressure. These hemodynamic alterations stimulate the baroreceptor reflex, which is mediated via the central nervous system to increase peripheral sympathetic vasomotor tone, restoring blood pressure and cardiac output within seconds-to-minutes of the assumption of the upright…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Trunk Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00426842"},{"n":"NCT01354158","t":"A Dose Titration of Droxidopa in Patients With Spinal Cord Injury","d":"The investigators seek to determine the efficacy, duration of action and safety of escalating dose of droxidopa on systemic blood pressure, cerebral blood flow and vasoactive hormones and catecholamines during upright seated posture. Primary Question: 1\\. What is the lowest dose of droxidopa that increases seated SBP to 115±5 mmHg in men and 105±5 mmHg in women? * When does the defined increase in SBP occur after oral ingestion of droxidopa? * How long does this dose of droxidopa sustain SBP at…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Trunk Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01354158"},{"n":"NCT01297608","t":"A Double Blinded Study to Examine the Effect of Coated Suppositories on Fecal Incontinence in Patients With Spinal Cord Injury","d":"This is a double blinded cross over study. Approximately 20 spinal cord injury patients will be participating in this 4 weeks study.The primary outcome is difference in fecal incontinence as recorded in diaries, between the treatment period and the treatment period.","s":"Withdrawn","tr":["Drugs"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01297608"},{"n":"NCT07170969","t":"A Feasibility Trial of an Enhanced Coping-oriented Supportive Programme for Community-dwelling People With Spinal Cord Injury","d":"Spinal cord injury (SCI) is a neurological disorder that leads to \"partial or complete loss of people's motor and/ or sensory function below the level of the injury\". This study is a single-group feasibility trial with pre- and post-assessment. The total sample size is 12. This is a feasibility trial of an Enhanced Coping-oriented Supportive Programme (E-COSP) for Community-Dwelling People with Spinal Cord Injury. Twelve SCI participants will be recruited from the Hong Kong Direction…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life","Sensory Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07170969"},{"n":"NCT06215625","t":"A Feasible Smart Upper Limb Rehabilitation Model for Patients With Stroke and Spinal Cord Injuries","d":"The goal of this clinical trial is to investigate the effectiveness of the developed application and exoskeleton robot devices for home-based training in stroke patients and patients with spinal cord injuries. The application that uses an Internet of Things (IoT) platform to enable remote monitoring of rehabilitation progress by clinical practitioners. Simultaneously, it seeks to assist the execution of patient movements through devices. In patients with stroke, half of the participants will be…","s":"Recruiting","tr":["Exoskeleton"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Taiwan"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06215625","su":"https://scitrials.org/trial/NCT06215625"},{"n":"NCT04670406","t":"A Guided Online ACT Intervention Combined With Psychoeducation for People With Spinal Cord Injury","d":"The purpose of this preliminary study is to examine the effects of a guided online acceptance and commitment therapy (ACT) intervention combined with psychoeducation on people with spinal cord injury (SCI) who experience psychological distress.","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04670406"},{"n":"NCT03025048","t":"A Holistic Dietary Intervention for Persons With Spinal Cord Injury","d":"People with spinal cord injury are at increased risk for overweight and obesity, type 2 diabetes, cardiovascular disease and decreased quality of life compared With able bodied. This pilot aims to assess the impact of a nutrition intervention that combines several methods to help people change their lifestyle. The pilot project combines individual interviews and personal lifestyle goals (diet) with group classes for people with long-standing spinal cord injury. In addition to nutrition theory…","s":"Completed","tr":["Nutrition","Observational"],"o":["Blood Pressure","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03025048"},{"n":"NCT02853149","t":"A Lifestyle Intervention Targeting Enhanced Health and Function for Persons With Chronic SCI in Caregiver/Care-Receiver Relationships: Effects of Caregiver Co-Treatment","d":"This study determines in people with chronic SCI the health and functional impact and user acceptance and satisfaction - of a 6-month comprehensive Lifestyle Intervention; the impact and user acceptance/satisfaction of a Complementary Caregiver Curriculum (CCC) on SCI caregiver health and function and whether the complementary caregiver curriculum (CCC) enhances health and functional benefits obtained by the SCI dyadic partner enrolled in the LI program.","s":"Completed","tr":[],"o":["Blood Pressure","Motor Function"],"st":["Colorado","Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02853149"},{"n":"NCT03023163","t":"A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences","d":"The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5. As the general population ages, the spinal cord injury (SCI) population is also aging and it is estimated that 14% is older than 60. Although persons with SCI are living longer, life expectancy remains below that of the general population with cardiovascular and cerebrovascular…","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03023163"},{"n":"NCT03644277","t":"A Multi-Center Clinical Trial in Individuals With Spinal Cord Injury","d":"The overall objective of this project is to investigate the effectiveness of daily acute intermittent hypoxia therapy (dAIH), coupled with massed practice training, to improve upper-extremity function in individuals with chronic incomplete cervical SCI.","s":"Active, not recruiting","tr":["Intermittent Hypoxia"],"o":["Arm Movement","Hand Movement"],"st":["Illinois","New Jersey"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03644277","su":"https://scitrials.org/trial/NCT03644277"},{"n":"NCT00592722","t":"A Multi-Centre Clinical Study in Chronic Spinal Cord Injury Patients","d":"To establish a solid foundation, e.g. network and a coordinating centre for testing new SCI therapies in forthcoming randomized controlled multi-centre clinical trials following international standards and guidelines","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["China","Taiwan"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00592722"},{"n":"NCT00517374","t":"A Multi-Centre Clinical Study in Spinal Cord Injury Patients in Mainland China and Hong Kong","d":"To establish a solid foundation, e.g. a network and a coordinating centre for testing new SCI therapies in forthcoming randomised controlled multi-centre clinical trials following international standards and guidelines.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["China"],"lc":17,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00517374"},{"n":"NCT03229031","t":"A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Safety and Efficacy of ES135 in Subjects With Spinal Cord Injury","d":"To demonstrate the superior effect of ES135 combined with spinal cord repairing surgery, compared to a placebo control with spinal cord repairing surgery, on post-surgery motor function recovery as measured by the changes from baseline of ISNCSCI Motor Scores in subjects","s":"Suspended","tr":["Drugs","Surgical Procedure"],"o":["Motor Function"],"st":[],"co":["Taiwan"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03229031"},{"n":"NCT01923662","t":"A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes","d":"The purpose of this study is to improve the performance of neuroprosthesis for standing after SCI by developing and testing new advanced methods that use multiple contact peripheral nerve electrodes to slow the onset of fatigue and increase standing duration. The new advanced methods will take advantage of the ability of multiple-contact nerve cuff electrodes to selectively activate portions of a muscle that perform the same action. Alternating activation to multiple muscles (or parts of the…","s":"Completed","tr":["Devices"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01923662"},{"n":"NCT01474148","t":"A Neuroprosthesis for Seated Posture and Balance","d":"The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips. FES involves applying small electric currents to the nerves, which cause the muscles to contract. This study evaluates how stabilizing and stiffening the trunk with FES can change the way spinal cord injured volunteers sit, breathe, reach, push a wheelchair, or roll in bed.","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01474148","su":"https://scitrials.org/trial/NCT01474148"},{"n":"NCT05940636","t":"A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity","d":"Many people with partial damages in their spinal cord (iSCI) have physical impairments such as muscle paralysis in legs which make standing balance difficult. Poor balance control often leads to falls, injuries, and hospitalization. Therefore, improvement of standing balance is an important therapeutic goal for these individuals. Our team has shown that a therapy called visual feedback training (VFT) can improve standing balance by allowing individuals with iSCI to actively participate and…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation","Transcutaneous Stimulation"],"o":["Leg Movement","Plasticity","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05940636"},{"n":"NCT05441449","t":"A Novel Cooling Vest to Protect Persons With SCI From Hyperthermia","d":"Persons with higher levels of spinal cord injury (above the 6th thoracic vertebrae: Hi-SCI) are unable to maintain their core body temperature (Tcore) within the normal range (97.5-99.7 °F) when exposed to warm environments. Even limited exposure to warm temperatures can cause hyperthermia (Tcore 100.4°F) in Hi-SCI. Mild hyperthermia causes discomfort and impaired thinking, but if unchecked, can lead to permanent damage to the brain, multiple body organ failure, and death. Warm seasonal…","s":"Completed","tr":["Devices"],"o":["Quality of Life","Sensory Function","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05441449"},{"n":"NCT06494059","t":"A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients","d":"The purpose of this research is to explore the effect of magnetic stimulation to activate the brain, electrical spinal cord stimulation to activate spinal cord, and electrical muscle stimulation used to activate upper limb (arms), lower limb (legs) and trunk (stomach) muscles in people with spinal cord injury (SCI) and able-bodied subjects (without SCI).","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06494059","su":"https://scitrials.org/trial/NCT06494059"},{"n":"NCT05243576","t":"A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES","d":"Neuromuscular electrical stimulation (NMES) remains as one of the effective rehabilitation modalities for addressing recovery of neuromuscular function after a spinal cord injury (SCI). To achieve optimal effects, the NMES interventions that involve or promote voluntary efforts from SCI participants are preferred. However, these interventions are limited by the fact that the active monitoring of voluntary effort, particularly at the stimulated muscle level is unattainable. The objective of the…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05243576","su":"https://scitrials.org/trial/NCT05243576"},{"n":"NCT02746978","t":"A Patient-centered Approach to Successful Community Transition After Catastrophic Injury","d":"Shepherd Center is bringing a more patient-centered focus to educational, peer-support, and technology resources offered to patients with spinal cord injury and their families and is evaluating these changes. Approximately 740 patients have provided information about healthcare utilization following inpatient rehabilitation. This information will help Shepherd Center staff follow utilization trends and plan programs targeted at the high-use areas.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02746978","su":"https://scitrials.org/trial/NCT02746978"},{"n":"NCT02522507","t":"A Peer E-mentoring Intervention to Improve Employment","d":"Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a work environment. Although youth with disabilities have much to gain from employment readiness programs, they are often excluded from, or have limited access to school and community vocational programs. One encouraging approach to address gaps in vocational programming…","s":"Completed","tr":[],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02522507"},{"n":"NCT05308953","t":"A Phase I Safety Study of NVG-291 in Healthy Adults","d":"This is a randomized, triple-blind (subjects, Investigators, and Sponsor blinded), placebo-controlled Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) study to evaluate the safety and tolerability of NVG-291 administered by subcutaneous injection daily in healthy female participants. The trial is split into three parts, starting with Part 1 (SAD), then Part 2 (MAD - post-menopausal Females), and finally Part 3 (MAD - males and premenopausal females). In Part 1 (SAD), participants…","s":"Completed","tr":["Drugs","Safety"],"o":[],"st":[],"co":["Australia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05308953"},{"n":"NCT03977922","t":"A Pilot Nutrition Program for Spinal Cord Injury and MS","d":"The purpose of this study is to determine the feasibility of a 12-week pilot community-based nutrition program for individuals with spinal cord injury and multiple sclerosis, and to determine the effects of the nutrition program on body composition, inflammation, neuropathic pain, depression and quality of life.","s":"Completed","tr":["Nutrition"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03977922"},{"n":"NCT06238492","t":"A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI","d":"This study seeks conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.","s":"Unknown","tr":[],"o":["Mental Health"],"st":["Colorado","New Jersey","Washington"],"co":["United States"],"lc":3,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06238492","su":"https://scitrials.org/trial/NCT06238492"},{"n":"NCT07093827","t":"A Prospective Cohort Study on the Effect of Spinal Spinal Cord Injury on Sexual Function in Male Patients","d":"1. Background and Rationale Spinal cord injury (SCI) represents a devastating neurological condition with multidimensional consequences. While motor and sensory deficits are well-characterized, sexual dysfunction remains understudied despite its profound impact on quality of life. Current literature exhibits three critical gaps: (1) Limited longitudinal data on the temporal evolution of sexual dysfunction post-SCI, (2) Inadequate differentiation between psychogenic vs. neurogenic mechanisms in…","s":"Active, not recruiting","tr":[],"o":["Sexual Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07093827","su":"https://scitrials.org/trial/NCT07093827"},{"n":"NCT00990093","t":"A Randomised, Cross-over, Open-labelled Test Catheter Acceptance Study","d":"The purpose of this study is to evaluate that the test catheter is no less accepted than the SpeediCath (SC) catheter.","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00990093"},{"n":"NCT00866112","t":"A Randomized Exercise Trial for Wheelchair Users","d":"People with mobility disabilities are at greater risk than the general population for incurring health problems. Many of these conditions are preventable through behavior and lifestyle changes such as exercise and physical activity. Recent evidence suggests that people with disabilities experience the same physiologic response to exercise as the general population. Nonetheless, nearly three-fourths of those with disabilities report being entirely sedentary or not active enough to achieve health…","s":"Completed","tr":[],"o":[],"st":["Kansas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00866112"},{"n":"NCT00557973","t":"A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury","d":"The purpose of this study is to evaluate efficacy and safety of treatment with XP19986 Sustained Release (SR) Tablet compared to placebo in subjects with spasticity due to spinal cord injury","s":"Completed","tr":["Drugs"],"o":["Spasticity"],"st":["California","Colorado","Florida","Georgia","Illinois","Kansas","Michigan"],"co":["United States"],"lc":11,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00557973"},{"n":"NCT00500812","t":"A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries","d":"This trial is a multi-center, open-label, dose-escalation study designed to evaluate the safety, tolerability and pharmacokinetics of Cethrin in two types of spinal cord injury patients: those with a complete cervical injury or a complete thoracic injury. Dose levels from 0.3 mg - 9 mg of Cethrin will be administered.","s":"Completed","tr":["Drugs","Safety"],"o":[],"st":["Arizona","Ohio","Pennsylvania","Virginia","Washington"],"co":["Canada","United States"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00500812"},{"n":"NCT01748695","t":"A Safety, Tolerability and Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury","d":"The purpose of this study is to investigate whether V158866 is safe and effective for the treatment of neuropathic pain due to spinal cord injury.","s":"Completed","tr":["Drugs","Safety"],"o":["Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01748695"},{"n":"NCT04955509","t":"A Scar Recognition Software for Chronic Spinal Cord Injury (SCI)","d":"To construct and validate a software to recognize scar for patients with chronic SCI based on multimodal MRI.","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04955509","su":"https://scitrials.org/trial/NCT04955509"},{"n":"NCT00224029","t":"A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition","d":"This study will evaluate the efficacy and safety of an anticholinergic drug treatment administered by transdermal patch to treat overactive bladder in adults who have spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bladder Function"],"st":["Georgia","New York","North Carolina","Texas"],"co":["United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00224029"},{"n":"NCT00654082","t":"A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction","d":"To demonstrate the efficacy, safety and tolerability of sildenafil administered orally, as required, approximately 1 hour prior to sexual activity to men with erectile dysfunction (ED) associated with spinal cord injury (SCI), as well as its effects on the quality of life (QoL) of these patients.","s":"Completed","tr":["Drugs","Safety"],"o":["Quality of Life","Sexual Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00654082"},{"n":"NCT07024407","t":"A Study of Andecaliximab in People With Spinal Cord Injury at Risk for Bone Growth Outside of the Normal Skeleton.","d":"This is an open-label study of andecaliximab in participants at risk of developing bone where bone should not be, such as in muscle, tendons, and other soft tissues following traumatic spinal cord injury. The goal of this study is to assess the safety of andecaliximab, how much drug is in the body over time (pharmacokinetics/PK), and how it affects the body (pharmacodynamics/PD) in participants who have had a recent traumatic spinal cord injury.","s":"Recruiting","tr":["Drugs"],"o":[],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07024407","su":"https://scitrials.org/trial/NCT07024407"},{"n":"NCT03253952","t":"A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.","d":"The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI). SCI-AI impair outcomes by (1) reducing the intrinsic neurological recovery potential and (2) increasing mortality. Heart Rate Variability (HRV) data will be tracked in both the time and frequency domains to discriminate between the relative contribution of sympathetic and parasympathetic innervation to…","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03253952","su":"https://scitrials.org/trial/NCT03253952"},{"n":"NCT00248807","t":"A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury.","d":"The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position. In this investigation we are studying blood pressure and blood flow to the brain, with and without a medication which lowers blood pressure (Vasotec). We will determine how persons with a spinal cord injury are able to maintain blood flow to the brain (not get dizzy) as they assume a more upright position and their blood pressure decreases.","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00248807"},{"n":"NCT01606202","t":"A Study of Cannabis Based Medicine Extracts and Placebo in Patients With Pain Due to Spinal Cord Injury","d":"A study to investigate the effects of sublingual cannabis based medicine extracts on neuropathic pain associated with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Pain Management","Quality of Life","Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01606202"},{"n":"NCT01337908","t":"A Study of Mood and Stress After Spinal Cord Injury","d":"This is a study of factors, such as pain, family support, psychological history and alcohol/substance use, that may influence whether a person experiences depression after their spinal cord injury.","s":"Completed","tr":["Observational"],"o":["Mental Health","Pain Management"],"st":["California","Michigan","Washington"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01337908"},{"n":"NCT06097000","t":"A Study of the Safety and Efficacy of Intelligent Powered Exoskeletons in Postoperative Spinal Rehabilitation","d":"Systematic and professional rehabilitation training is generally effective for patients with lower limb dyskinesia, but most of them lose the chance of recovery due to failure to receive systematic rehabilitation treatment. Our team has developed an intelligent power armor for patients with lower limb motor dysfunction, which can assist patients to complete high-quality rehabilitation training. In order to evaluate the safety and efficacy of the Smart Power Armor for post-surgical spine…","s":"Recruiting","tr":["Devices","Exoskeleton","Rehabilitation","Surgical Procedure"],"o":["Leg Movement","Motor Function","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06097000"},{"n":"NCT06944834","t":"A Study on the Safety and Functionality of the Implantable Wireless Brain-Computer Interfaces for Motor Rehabilitation","d":"The objective of this study is to evaluate the safety and efficacy of minimally invasive, wireless brain-machine interface system (WRS) in patients with paralysis (resulting from spinal cord injuries, brainstem strokes, amyotrophic lateral sclerosis, or other motor neuron diseases causing complete or incomplete quadriplegia) or bilateral upper limb amputations. By leveraging brain-machine interface alternative technology, participants can use brain signals to control external devices (such as…","s":"Not yet recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06944834","su":"https://scitrials.org/trial/NCT06944834"},{"n":"NCT00725790","t":"A Study to Evaluate the Efficacy and Safety of Vardenafil in Men With Erectile Dysfunction Caused by Spinal Cord Injury","d":"The purpose of this study is to determine if 12 weeks of flexible-dose vardenafil therapy demonstrates superior efficacy compared to placebo in subjects with ED solely secondary to a traumatic spinal cord injury","s":"Unknown","tr":["Drugs"],"o":["Sexual Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00725790","su":"https://scitrials.org/trial/NCT00725790"},{"n":"NCT06841770","t":"A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury","d":"The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI). LCTOPC1 is designed to replace or support cells that are absent or dysfunctional due to traumatic injury, with a goal to help improve the quality of life and restore or augment functional activity in persons suffering from a traumatic cervical or thoracic injuries.","s":"Recruiting","tr":[],"o":["Regeneration"],"st":["California"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06841770","su":"https://scitrials.org/trial/NCT06841770"},{"n":"NCT04977037","t":"A Telerehabilitation Program for SCI","d":"This study evaluates a remotely supervised, home-based therapeutic program to improve upper-limb voluntary movement in adults with tetraplegia caused by incomplete spinal cord injury (iSCI).","s":"Completed","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04977037"},{"n":"NCT07799532","t":"A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury","d":"The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291. The main questions it aims to answer are: * Does NVG-291 improve hand function and daily activities? * What side effects do participants have when taking NVG-291? Researchers will compare NVG-291 to a placebo (a look-alike substance that does not contain NVG-291) to see if NVG-291 improves function in…","s":"Not yet recruiting","tr":["Drugs","Safety"],"o":["Blood Pressure","Hand Movement","Motor Function","Quality of Life","Spasticity","Temperature Control","Walking Function"],"st":["Alabama","California","Colorado","Connecticut","District of Columbia","Florida","Georgia","Maryland","Michigan","New Jersey","North Carolina","Pennsylvania","South Carolina","Texas","Wisconsin"],"co":["Canada","United States"],"lc":18,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07799532"},{"n":"NCT07036107","t":"A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the Spanish Healthcare System","d":"This clinical trial aims to collect evidence on the clinical benefits and the socioeconomic impact of integrating a novel wearable powered lower-limb exoskeleton for gait rehabilitation in acute/subacute spinal cord injured individuals and to evaluate the efficiency of this technology to the current standard of care in the Spanish Healthcare System (SNS).. The main questions it aims to answer are: * Is robotic therapy for gait rehabilitation more effective and efficient than conventional…","s":"Recruiting","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":[],"co":["Spain"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07036107","su":"https://scitrials.org/trial/NCT07036107"},{"n":"NCT00712322","t":"A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity","d":"This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity. The results will support a benefit-risk based dosage recommendation for phase IIIa clinical trials.","s":"Terminated","tr":["Drugs"],"o":["Bladder Function"],"st":["California","Massachusetts","Michigan","Missouri","New York","Ohio","Oregon"],"co":["Colombia","United States"],"lc":12,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00712322"},{"n":"NCT06087445","t":"A User-friendly, Non-invasive Neuro-orthosis That Restores Volitionally Controlled Grasp Functions for SCI Survivors With Tetraplegia","d":"The goal of this pilot clinical study is to investigate the NeuroLife EMG-FES Sleeve System, a closed-loop approach to functional electrical stimulation, in adults (n=12) with chronic (\\>12 months) tetraplegia due to spinal cord injury. Briefly, the NeuroLife EMG-FES System is a completely non-invasive system (surface electrodes only, no implantable components) worn on the forearm which has up to 160 electrodes that can record electromyography (EMG), or muscle activity, and also electrically…","s":"Completed","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06087445"},{"n":"NCT04009187","t":"A Wheelchair Propulsion Training Program","d":"The overall purpose of this project is to test the feasibility of a manual wheelchair propulsion program which aims to reduce the chance of development of upper limbs pain and injury.","s":"Completed","tr":[],"o":["Pain Management"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04009187"},{"n":"NCT02803255","t":"AAN Robotic Therapy in SCI","d":"The purpose of this study is to demonstrate that a robot-aided rehabilitation protocol that follows the \"assist-as needed\" paradigm provide statistically significant improvements in arm and hand motor functions when compared to robot-aided protocols that passively move patients' arms along pre-defined trajectories, in patients with incomplete spinal cord injury (SCI).","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Hand Movement","Motor Function","Spasticity"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02803255"},{"n":"NCT06948175","t":"Abdominal Electrical Stimulation for Bowel Dysfunction in SCI","d":"Many people with spinal cord injury (SCI) have bowel problems resulting in constipation and need a long time to empty the bowel. Some people spend an hour or more to empty their bowel. The investigators want test if using a small device to deliver electrical pulses to the belly (abdomen), would improve bowel function. The investigators hope that electrical stimulation will shorten the time needed to evacuate the bowel (defecation), improve stool consistency, and speed up food passing through…","s":"Enrolling by invitation","tr":["Electrical Stimulation"],"o":["Bowel Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06948175","su":"https://scitrials.org/trial/NCT06948175"},{"n":"NCT02200393","t":"Abdominal Functional Electrical Stimulation (AFES) to Assist Ventilator Weaning in Tetraplegia","d":"Compromised respiratory function as a result of tetraplegia leads to many tetraplegics requiring mechanical ventilation during the acute phase of injury. Mechanical ventilation is associated with additional costs to the local health care provider and reduced quality of life of the patient. Electrical stimulation of the abdominal muscles has previously been used to improve the respiratory function of tetraplegic patients in the chronic stage of injury. In this study the investigators aim to…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Breathing Function","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02200393"},{"n":"NCT00202631","t":"Abdominal Functional Electrical Stimulation in Tetraplegia","d":"People with high spinal lesions are at risk of respiratory complications because they have partial or complete paralysis of breathing muscles. Previous work has shown that tetraplegic lung volumes can be increased by using abdominal FES during expiration. The technique is attractive because it is non-invasive, painless in tetraplegia and completely reversible. It may provide a treatment for augmenting the patient's breathing both in the acute presentation of spinal injury (when half of cervical…","s":"Unknown","tr":["Functional Electrical Stimulation (FES)"],"o":["Breathing Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00202631","su":"https://scitrials.org/trial/NCT00202631"},{"n":"NCT06345781","t":"Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury","d":"The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI. This study will also evaluate whether abdominal FES can improve: 1) bowel-related quality of life, 2) participant-reported bowel function, 3) bowel management strategy, 4) bladder symptoms, and 5) unplanned hospital admissions. In addition, we will also explore participant perspectives and experiences about the stimulation…","s":"Recruiting","tr":[],"o":["Bowel Function"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06345781","su":"https://scitrials.org/trial/NCT06345781"},{"n":"NCT01800409","t":"Abdominal Functional Electrical Stimulation Training and Its Effect on Mechanical Insufflation-Exsufflation","d":"Compromised respiratory function as a result of tetraplegia is a leading cause of rehospitalisation for the tetraplegic patient group. Electrical stimulation of the abdominal muscles has previously been used to improve the respiratory function of tetraplegic patients in the chronic stage of injury. In this study the investigators aim to evaluate the optimum protocol for the use of electrical stimulation of the abdominal muscles to improve the respiratory function of the tetraplegic population…","s":"Unknown","tr":["Functional Electrical Stimulation (FES)"],"o":["Breathing Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01800409","su":"https://scitrials.org/trial/NCT01800409"},{"n":"NCT07626931","t":"Abdominal Stimulation to Improve Cough After Spinal Cord Injury","d":"The goal of this clinical trial is to learn if abdominal functional electrical stimulation (FES) using the VentFree Respiratory Muscle Stimulator improves cough strength in adults with a new spinal cord injury (SCI). It will also learn about the safety of abdominal FES in this population. The main questions it aims to answer are: Does abdominal FES improve cough peak flow (a measure of cough strength) compared to cough training alone? Does abdominal FES reduce the number of respiratory…","s":"Not yet recruiting","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Trunk Control"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07626931","su":"https://scitrials.org/trial/NCT07626931"},{"n":"NCT02970773","t":"Absorption of Rivaroxaban in Patients With Cervical Spinal Cord Injury","d":"The primary objective of this study is to investigate the pharmacokinetic and -dynamic properties of rivaroxaban after oral administration in cervical spinal cord injury (SCI) individuals. The secondary objective of this study is to determine the steady-state rivaroxaban activity in cervical SCI individuals under long-term therapy. Primary Objective In-house patients will be informed concerning the study and informed consent will be collected. During the screening day, in- / exclusion criteria…","s":"Withdrawn","tr":["Devices","Drugs"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02970773"},{"n":"NCT01750684","t":"AC105 in Patients With Acute Traumatic Spinal Cord Injury","d":"The principal aim of this study was to establish the feasibility of rapid administration, safety, and tolerability of AC105 in patients with acute spinal cord injury.","s":"Terminated","tr":["Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01750684"},{"n":"NCT06098170","t":"Acceptance and Commitment Therapy for Chronic Pain in SCI: Development and Testing of an eHealth Program","d":"This study will test the newly-developed My spinal cord injury (SCI) Toolkit program in two formats - unguided use of the program and use supported by a coach. These two active treatment formats will be compared to treatment as usual (waitlist control) in adults with chronic pain and SCI. Hypotheses include: * Treatment adherence, participant satisfaction, and perception of positive change will be high and drop-out rates low for both treatments but will be better in the coached compared to the…","s":"Completed","tr":[],"o":["Pain Management","Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06098170"},{"n":"NCT05725161","t":"Acceptance and Commitment Therapy for Depressed Individuals Living With Spinal Cord Injury Sustained Within 5 Years","d":"This randomized controlled trial aims to assess effects of videoconferencing acceptance and commitment therapy (ACT) on mental health outcomes in individuals living with spinal cord injuries (SCI). A total of 34 individuals living with SCI sustained within 5 years and experiencing depressive symptoms will be recruited and randomly assigned to either the ACT group or the wait-list control group. The ACT group will receive 8 weekly individual ACT sessions guided by a coach through…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05725161"},{"n":"NCT06233656","t":"Acceptance and Commitment Therapy for Depressed People With Spinal Cord Injuries","d":"Living with spinal cord injury (SCI) can have a significant negative impact on an individual's mental health and restrict participation in personally valued activities and roles. Acceptance and commitment therapy (ACT) is an evidence-based approach that can lessen symptoms of mental health disorders (e.g., depressive symptoms) and improve quality of life through mindfulness and acceptance processes and behavior change processes for valued living. Evidence for ACT for individuals living with…","s":"Active, not recruiting","tr":[],"o":["Mental Health"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06233656","su":"https://scitrials.org/trial/NCT06233656"},{"n":"NCT06159946","t":"Access-H20 Faucet for Spinal Cord Injury","d":"The Phase I SBIR objective is to design, develop \\& demonstrate feasibility of Access-H2OTM, a sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury (SCI). SCI severely impacts functional independence \\& ability to perform activities of daily living (ADLs). Greater function is typically lost with higher, more complete injuries. More specifically, those impacted above C5-C7 have impaired upper extremities, which limits…","s":"Completed","tr":["Devices"],"o":["Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06159946"},{"n":"NCT07062796","t":"Access-H20: Sensor-driven Smart Faucet","d":"The objective of the SBIR Phase II study is to evaluate the updated Access-H2O™ system, a sensor-driven smart faucet developed during the Phase I SBIR project, to enhance independent drinking and grooming among individuals with spinal cord injury (SCI) in both clinical and home settings. SCI significantly impairs functional independence and the ability to perform activities of daily living (ADLs), with greater loss of function associated with higher and more complete injuries. In particular…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07062796"},{"n":"NCT07603258","t":"Access-H20: Sensor-driven Smart Faucet Related Study","d":"The objective of the SBIR Phase II study is to evaluate the updated Access-H2O™ system, a sensor-driven smart faucet developed during the Phase I SBIR project, to enhance independent drinking and grooming among individuals with spinal cord injury (SCI) in both clinical and home settings. SCI significantly impairs functional independence and the ability to perform activities of daily living (ADLs), with greater loss of function associated with higher and more complete injuries. In particular…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07603258"},{"n":"NCT02307526","t":"Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI","d":"Due to de-centralized cardiovascular control, persons with spinal cord injury (SCI) experience blood pressure (BP) dysregulation which manifests in chronic hypotension with exacerbation during orthostatic positioning. Although many individuals with SCI remain asymptomatic to hypotension and orthostatic hypotension (OH), we recently reported reduced memory and marginally reduced attention and processing speed in hypotensive individuals with SCI compared to a normotensive cohort. Thus, we believe…","s":"Completed","tr":["Devices","Drugs"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02307526"},{"n":"NCT05429736","t":"Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity","d":"For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation training and access to facilities, qualified staff, and advanced technology that make practicing walking at home difficult. For this reason, developing training approaches that could be easily performed in the home would be of great value. In addition, non-invasive spinal…","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05429736","su":"https://scitrials.org/trial/NCT05429736"},{"n":"NCT03696927","t":"Active Powered Prosthesis (APEX) for Spinal Cord Injury","d":"The Active Powered Prosthesis (APEX) (AbiliTech Medical Inc., Minneapolis, MN) is a proof-of-concept shoulder-elbow-wrist device intended to provide non-invasive active powered robotic assistive movement to upper extremities. The objective of this study is to perform focus groups with users and clinicians to evaluate a proof of concept active powered assistance device.","s":"Completed","tr":["Devices"],"o":["Arm Movement"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03696927"},{"n":"NCT05390853","t":"Active tDCS Versus Sham tDCS for Upper Limb Recovery in Incomplete Tetraplegic Patients","d":"Spinal Cord Injury (SCI) at the cervical level results in motor and sensory impairment below the lesion level and may determine a consistent loss of the use of the upper limbs, with a substantial impact on daily life activities. Therefore, functionality recovery of the upper limbs, of the hands in particular, represents a priority rehabilitation target. Studies in the literature show that the most relevant recovery occurs in the first months after SCI and that neuromodulation techniques may…","s":"Terminated","tr":["Electrical Stimulation","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Hand Movement","Motor Function","Pain Management","Spasticity"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05390853"},{"n":"NCT03261388","t":"Activity Based Locomotor Exercise PrOgram-Wait-list controllEd Research","d":"At Courage Kenny Rehabilitation Institute, rehabilitation for individuals with spinal cord injury (SCI) is being led by the NIH funded NeuroRecovery Network (NRN) Community Fitness and Wellness Program through the Activity-Based Locomotor Exercise Program (ABLE). Any individual with a spinal cord injury who is eligible for the ABLE Program is eligible for participation in the NeuroRecovery Network Research Project (NRN). The purpose of the ABLE POWER Study is to evaluate the effectiveness of…","s":"Terminated","tr":["Observational","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03261388"},{"n":"NCT02309983","t":"Activity Dependent Rehabilitation Model to Improve Bone and Muscle Outcomes","d":"For many after spinal cord injury (SCI) there is immobilization, muscle atrophy, bone loss, fracture risk during transferring (or falls), and the risk of secondary complications, and increase in attendance care and cost. It is important to develop multi dimensional rehabilitation strategies for people after SCI to enhance functional recovery towards walking, and enhance an increase in muscle and bone to potentially prepare the injured nervous system in the event of a cure. Locomotor training…","s":"Unknown","tr":[],"o":["Bone Strength"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02309983","su":"https://scitrials.org/trial/NCT02309983"},{"n":"NCT06472986","t":"Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)","d":"The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06472986","su":"https://scitrials.org/trial/NCT06472986"},{"n":"NCT03669302","t":"Activity-Dependent Transspinal Stimulation in SCI","d":"Robotic gait training is often used with the aim to improve walking ability in individuals with Spinal Cord Injury. However, robotic gait training alone may not be sufficient. This study will compare the effects of robotic gait training alone to robotic gait training combined with either low-frequency or high-frequency non-invasive transspinal electrical stimulation. In people with motor-incomplete SCI, a series of clinical and electrical tests of nerve function will be performed before and…","s":"Terminated","tr":["Electrical Stimulation","Exoskeleton","Rehabilitation"],"o":["Motor Function","Plasticity","Spasticity","Walking Function"],"st":["New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03669302"},{"n":"NCT00432289","t":"Acupuncture for Treatment of Acute Spinal Cord Injury: an Exploratory/Developmental Study","d":"Specific Aim: to implement and evaluate a research protocol for demonstrating the efficacy of Acupuncture Therapy to improve neurological recovery after incomplete SCI compared to a control protocol. Hypothesis: acupuncture treatment results in greater neurological recovery than a control treatment after an incomplete SCI. Before conducting a larger, more definitive study, this exploratory and developmental work is focused on assessing whether blinding is possible, reproducibility of the…","s":"Completed","tr":[],"o":[],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00432289"},{"n":"NCT03197675","t":"Acupuncture in Spinal Cord Injury Subjects","d":"Of the more than 250,000 Americans with severe spinal cord injury (SCI), 42,000 are military veterans. The Department of Veterans Affairs is the largest single network of SCI care providers in the nation. Patients with SCI experience functional disabilities as well as chronic pain. Studies show that individuals with SCI report pain refractory to conventional treatments. Civilian and veteran patients with SCI have associated pain with impairments in physical and cognitive function, sleep…","s":"Completed","tr":[],"o":["Bladder Function","Pain Management","Quality of Life"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03197675"},{"n":"NCT00523016","t":"Acupuncture Treatment to Reduce Burning Pain in Spinal Cord Injury","d":"Acupuncture has been used with good results for many years at Toronto Rehabilitation Institute Lyndhurst Centre (Toronto, ON, Canada), Parkwood Hospital (London, ON, Canada) and GF Strong Rehabilitation Institute (Vancouver, BC, Canada) to reduce burning pain in individuals with spinal cord injuries (SCI). This multi-centre RCT will test an acupuncture protocol for treatment of burning pain in 40 people with burning pain in SCI, using a sham acupuncture protocol as the control. Objectives of…","s":"Completed","tr":["Rehabilitation"],"o":["Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00523016"},{"n":"NCT01353599","t":"Acute and Chronic Effects of Inhaled Steroids on Pulmonary Function in Persons With Spinal Cord Injury","d":"Individuals with chronic cervical SCI are known to have a restrictive ventilatory defect due to complete or partial loss of respiratory muscle innervation which is dependent upon the level and completeness of injury \\[2\\]. In addition, they share many aspects of obstructive airway physiology commonly associated with asthma. In asthma, physiological responses such as decrease in baseline airway caliber, bronchodilatation following inhalation of a beta-2-adrenergic agonist or anticholinergic…","s":"Unknown","tr":["Drugs"],"o":["Breathing Function"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01353599","su":"https://scitrials.org/trial/NCT01353599"},{"n":"NCT07210411","t":"Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury","d":"The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \\& cardiovascular function in participants with spinal cord injury.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07210411","su":"https://scitrials.org/trial/NCT07210411"},{"n":"NCT03143179","t":"Acute Cardiac Responses to Spinal Cord Injury","d":"The immediate period after spinal cord injury (SCI) is one of the only opportunities that clinicians and care-givers have to make a real difference to patient outcomes. One of the main aims during this period is to preserve blood flow and oxygen delivery to the spinal cord to prevent any further damage from occurring after the injury. The heart acts as the major pump for blood to be pumped to the spinal cord and the body. It has been shown in small animal models and in humans with long-standing…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03143179","su":"https://scitrials.org/trial/NCT03143179"},{"n":"NCT03267212","t":"Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury","d":"The investigators have an existing exercise program (N\\>70) with a unique population of individuals with spinal cord injury (SCI) who have been enrolled in Functional Electrical Stimulation - Rowing Training (FES-RT) for at least 6 months. Previous data in the laboratory from this exercise platform has recently showed that respiratory restriction in SCI reduces inspiratory capacity in direct relation to lesion level, and those with high level injuries have the greatest compromise. As a result…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03267212"},{"n":"NCT05061160","t":"Acute Effects of Continuous Verses Interval Aerobic Training in Spinal Cord Injury Patient","d":"To determine the Acute effects of continuous verses interval aerobic training on autonomic dysreflexia in Spinal Cord injury Patient. To Determine the Acute effects of these training on, Exercise Self efficacy and pain.","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Pain Management","Quality of Life"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05061160"},{"n":"NCT04052776","t":"Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES","d":"In a current first-in-man study, called Stimulation Movement Overground (STIMO) (NCT02936453; CER-VD: 04-2014; Swissmedic: 2016-MD-0002), epidural electrical stimulation (EES) of the spinal cord is applied to enable individuals with severe spinal cord injury (SCI) to complete intensive locomotor neurorehabilitation training. In this clinical feasibility study, it was demonstrated that EES results in an immediate enhancement of locomotor functions and that when applied repeatedly as part of a…","s":"Completed","tr":["Drugs","Electrical Stimulation","Epidural Stimulation"],"o":["Blood Pressure","Leg Movement","Motor Function","Spasticity","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04052776"},{"n":"NCT05626816","t":"Acute Genital Nerve Stimulation for Neurogenic Bowel Dysfunction in Individuals Living With Spinal Cord Injury","d":"Bowel issues occur in nearly all people after spinal cord injury (SCI) and one major complication is fecal incontinence (accidents). This complication has been repeatedly highlighted by people living with SCI as particularly life-limiting and in need of more options for interventions. This study will test the effect of genital nerve stimulation (GNS), with non-invasive electrodes, on the activity of the anus and rectum of persons after SCI. Recording anorectal manometry (ARM) endpoints tells us…","s":"Recruiting","tr":[],"o":["Bowel Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05626816","su":"https://scitrials.org/trial/NCT05626816"},{"n":"NCT02441179","t":"Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients","d":"Spinal cord injury (SCI) interrupts descending synaptic pathways from brainstem premotor neurons to spinal motor neurons, thereby paralyzing muscles below the neurological level. In recent years, considerable evidence has demonstrated that acute intermittent hypoxia (AIH) elicits plasticity in the spinal cord and strengthens spare synaptic pathways which is expressed as respiratory and somatic functional recovery in animals and humans suffering from incomplete SCI. The fundamental hypothesis…","s":"Completed","tr":["Drugs","Intermittent Hypoxia","Rehabilitation"],"o":["Bone Strength","Breathing Function","Pain Management","Plasticity","Spasticity","Walking Function"],"st":[],"co":["Chile"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02441179"},{"n":"NCT02274116","t":"Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury","d":"The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time. The investigators hypothesize: * Acute intermittent hypoxia (AIH) exposure will increase maximum voluntary leg strength in persons with incomplete cervical spinal cord injury (SCI) * AIH exposure will increase multijoint reflex excitability of leg muscles in persons with incomplete…","s":"Active, not recruiting","tr":["Intermittent Hypoxia","Rehabilitation"],"o":[],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02274116","su":"https://scitrials.org/trial/NCT02274116"},{"n":"NCT04843137","t":"Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord","d":"The purpose of this study is to examine how delivery of subthreshold electrical stimulation of the spinal cord alters the excitability of neural pathways and consequently movement performance in healthy and spinal cord injured individuals. Specifically, we assess how stimulation parameters such as electrode configurations and stimulation frequency affect spinal excitability, corticospinal excitability, intracortical excitability, motor unit properties and force production. This study is not an…","s":"Withdrawn","tr":["Brain Stimulation","Electrical Stimulation","Observational","Transcutaneous Stimulation"],"o":["Plasticity"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04843137"},{"n":"NCT00406016","t":"Acute Safety, Tolerability, Feasibility and Pharmacokinetics of Intrath. Administered ATI355 in Patients With Acute SCI","d":"This study will evaluate the acute safety, tolerability, feasibility and pharmacokinetics of 6 dose regimens of ATI355 in acute spinal cord injury patients","s":"Completed","tr":["Drugs","Safety"],"o":[],"st":[],"co":["Canada","Germany","Switzerland"],"lc":14,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00406016"},{"n":"NCT01197599","t":"Acute Tendon and Nerve Responses to Exercise","d":"The purpose of this study is to use ultrasound to analyze the effects of a bout of circuit training on the upper extremity of persons with spinal cord injury and able-bodied controls.","s":"Completed","tr":["Observational"],"o":["Arm Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01197599"},{"n":"NCT04893590","t":"Adapting MHealth Technology to Improve Patient Activation","d":"Persons with disabilities (PwD) commonly experience fatigue, which often negatively impacts their everyday lives. Management of this symptom can be challenging. Satisfaction with current interventions to manage fatigue is low among PwD and there is a desire for more personalized approaches. The purpose of this study is to develop and test a fatigue self-management intervention using mobile phones that is personalized to each person's needs.","s":"Completed","tr":[],"o":[],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04893590"},{"n":"NCT04247828","t":"Adaptive and Individualized AAC","d":"This project will test the feasibility of developing a smart augmentative or alternative communication (AAC) system that is effective in delivering communication capabilities that automatically adapt to the users' physical abilities.","s":"Completed","tr":["Devices"],"o":[],"st":["Massachusetts","Nebraska"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04247828"},{"n":"NCT02527304","t":"Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery","d":"This pilot clinical trial studies adaptive staged stereotactic body radiation therapy (SBRT) in treating patients with spinal metastases that cannot be removed by surgery. SBRT is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may kill more tumor cells and cause less damage to normal tissue. Adaptive SBRT uses information gathered during treatment to inform, guide, and alter future radiation treatments. Staged SBRT uses multiple…","s":"Completed","tr":["Surgical Procedure"],"o":["Pain Management","Quality of Life","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02527304"},{"n":"NCT07722962","t":"Additional Phase 3 Study of KP-100IT in Subjects With Acute Spinal Cord Injury","d":"This is a Phase 3, multicenter, open-label, single-arm additional study to evaluate the efficacy of intrathecal KP-100IT in patients with acute spinal cord injury. Eligible patients will receive KP-100 0.6 mg/body by intrathecal administration once per week for a total of 5 doses and will be followed for approximately 24 weeks after the first dose.","s":"Not yet recruiting","tr":["Drugs"],"o":["Arm Movement","Motor Function","Sensory Function"],"st":[],"co":["Japan"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07722962"},{"n":"NCT06538974","t":"Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population","d":"In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990. It has been suggested that current rehabilitation frameworks (inpatient, outpatient, and community-based) are insufficient to meet local population needs due to issues like long waiting times, lack of facilities, prioritization, funding, and accessibility.Patients with lower limb weaknesses, resulting from various conditions (for example stroke, traumatic brain…","s":"Recruiting","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Bladder Function","Bowel Function","Leg Movement","Mental Health","Motor Function","Quality of Life","Sensory Function","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06538974"},{"n":"NCT03308565","t":"Adipose Stem Cells for Traumatic Spinal Cord Injury","d":"The purpose of this study is to determine if mesenchymal stem cells (MSC) derived from the fat tissue can be safely administered into the cerebrospinal fluid (CSF) of patients with spinal cord injury. Adipose-derived mesenchymal stem cells (AD-MSCs) have been used in previous research studies at the Mayo Clinic. All subjects enrolled in this study will receive AD-MSC treatment, which is still experimental and is not approved by the U.S. Food and Drug Administration (FDA) for large scale use…","s":"Completed","tr":["Drugs","Stem Cells"],"o":["Motor Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03308565"},{"n":"NCT00594594","t":"Adjuntive Probiotic Therapy in Treating Urinary Tract Infections in Spinal Cord Injury","d":"We hypothesize that probiotic Lactobacillus can augment antibiotic treatment of symptomatic urinary tract infection (UTI) in spinal cord injured patients, and also increase the time to the next episode of UTI.","s":"Terminated","tr":["Nutrition"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00594594"},{"n":"NCT00785278","t":"Adjusting Wheelchair Set-Up to Minimize Shoulder Joint Forces During Propulsion","d":"Individuals who use a manual wheelchair depend upon their upper limbs to provide a means of locomotion during completion of their activities of daily living. As a result of greater than normal usage of the upper limbs, shoulder pain and pathology is common among manual wheelchair users. Accordingly, proper wheelchair set-up may be paramount to preventing injuries and maintaining comfort during locomotion. The purpose of this research study is to create a subject-specific computer model of…","s":"Unknown","tr":["Observational"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00785278","su":"https://scitrials.org/trial/NCT00785278"},{"n":"NCT02570932","t":"Administration of Expanded Autologous Adult Bone Marrow Mesenchymal Cells in Established Chronic Spinal Cord Injuries","d":"The purpose of this study is to analyze the potential clinical efficacy of intrathecal administration, in the subarachnoid space, of in vitro expanded autologous adult bone marrow mesenchymal stem cells in the treatment of patients with established chronic spinal cord injury (LEM).","s":"Completed","tr":["Stem Cells"],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02570932"},{"n":"NCT04141891","t":"Advancing Understanding of Transportation Options","d":"This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers. This multi-site trial will (1) test the driving decision aid (DDA) in improving decision making and quality (knowledge, decision conflict, values concordance and behavior intent); and (2) determine its effects on specific subpopulations of older drivers (stratified for cognitive function, decisional capacity…","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Mental Health"],"st":["California","Colorado","Indiana"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04141891"},{"n":"NCT02850133","t":"Aerobic Exercise and Blood Biochemical Factors in Spinal Cord Injury","d":"Background: Patients with spinal cord injury (SCI) have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literature regarding the effect of aerobic training on patients with SCI is scarce. This study evaluated changes in parameters of exercise physiology and serum myokines immediately after exercise and after a training program among patients with SCI. Method: Male patients with SCI and…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Breathing Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02850133"},{"n":"NCT07699094","t":"AI-Guided Predictions of Blood Pressure Dysregulation Using Perfusion Index as a Novel Biomarker in Persons With Spinal Cord Injury","d":"The goal of this clinical trial is to determine if perfusion index (PI) can reliably predict changes in systolic blood pressure (SBP) in persons with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI can be 18-75 years of age, male or female, neurological level of injury C4-T12, ASIA Impairment Scale (AIS: A or B: motor complete) or gender and healthy age-matched able-bodied (AB) controls. The main question this study aims to answer is: can PI reliably predict…","s":"Recruiting","tr":[],"o":["Blood Pressure","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07699094"},{"n":"NCT07452133","t":"AI-Powered Closed-Loop Multielectrode Transcutaneous Spinal Cord Stimulation: Real-Time Adjustments for Enhanced Motor Recovery in Spinal Cord Injury (AIM RECOVER)","d":"Spinal cord injury (SCI) often results in persistent motor deficits that are inadequately addressed by conventional rehabilitation. Transcutaneous spinal cord stimulation (tSCS) is a promising non-invasive neuromodulatory approach that can enhance motor activation and gait performance; however, current tSCS systems rely on static, pre-programmed stimulation parameters that do not adapt to real-time motor output or task demands. This limitation may reduce muscle selectivity and disrupt the…","s":"Not yet recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Walking Function"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07452133","su":"https://scitrials.org/trial/NCT07452133"},{"n":"NCT03780829","t":"AIH for Spinal Cord Repair","d":"Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life. Promoting neuroplasticity may support upper limb recovery after SCI. Repetitive exposure to acute intermittent hypoxia (rAIH) combined with motor training promotes recovery of motor function after SCI; however, the overall effects of rAIH/training are limited. The investigators will use an adult rat model of long-term contusive…","s":"Terminated","tr":["Drugs","Intermittent Hypoxia","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Plasticity","Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03780829"},{"n":"NCT02632422","t":"AIH-induced Walking Recovery After Subacute SCI","d":"The purpose of this study is to determine how mild breathing bouts of low oxygen may restore walking and leg strength in persons who have sustained a spinal cord injury.","s":"Active, not recruiting","tr":["Intermittent Hypoxia"],"o":["Walking Function"],"st":["Georgia","Massachusetts"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02632422","su":"https://scitrials.org/trial/NCT02632422"},{"n":"NCT04721717","t":"AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis","d":"The UAB Institute for Arts In Medicine (AIM) is currently implementing an expressive emotional writing pilot project for adults with paralysis caused by neurological conditions such as traumatic head or spinal cord injury.","s":"Recruiting","tr":[],"o":["Mental Health"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04721717","su":"https://scitrials.org/trial/NCT04721717"},{"n":"NCT02508311","t":"Albuterol to Improve Respiratory Strength in SCI","d":"Spinal cord injury (SCI), especially involving the cervical and upper thoracic segments, can significantly compromise respiratory muscle function. Respiratory complications can ensue, including lung collapse and pneumonia, which are the primary cause for mortality in association with traumatic SCI both during the acute and chronic phases post-injury. Lesions at the level of the cervical or high thoracic spinal cord result in respiratory muscle weakness, which is associated with ineffective…","s":"Terminated","tr":["Drugs"],"o":["Breathing Function","Motor Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02508311"},{"n":"NCT03057652","t":"Algorithmic-Based Evaluation and Treatment Approach for Robotic Gait Training","d":"The purpose of this study is to develop an algorithmic-based evaluation and treatment approach for wearable robotic exoskeleton (WRE) gait training for patients with neurological conditions.","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03057652","su":"https://scitrials.org/trial/NCT03057652"},{"n":"NCT04331405","t":"Allogeneic Cord Blood Cells for Adults With Severe Acute Contusion Spinal Cord Injury","d":"Study evaluates the safety and primary efficiency of systemic (i.v.) allogeneic human umbilical cord blood mononuclear cell infusions in patients with severe acute contusion spinal cord injury (ASIA A/B). 20 patients were included. Half of patients received cell therapy in addition to standard therapy, while the other half received standard therapy only.","s":"Completed","tr":[],"o":["Bladder Function","Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Russia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04331405"},{"n":"NCT05515419","t":"Allogeneic Cord Blood for Neurological Diseases in Adults","d":"This open label trial is conducted to investigate the efficacy and safety of allogeneic umbilical cord blood therapy for adult patients with neurological diseases.","s":"Withdrawn","tr":[],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05515419"},{"n":"NCT03317288","t":"Alternating Pressure Overlay on Weight Bearing Tissue Tolerance in People With Spinal Cord Injury","d":"The purpose of this study is to test if the newly-developed Dabir alternating pressure (AP) overlay could be beneficial to preventing skin damage during daily activities, such as lying in bed. Specifically, the study is being done to test if the Dabir AP overlay could be used to increase skin tolerance when lying in bed for an extended period of time (40 minutes), including reducing pressure and increasing skin blood flow (amount of blood supply to oxygen and nutrients to skin) as compared to…","s":"Completed","tr":["Electrical Stimulation"],"o":["Pressure Sores"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03317288"},{"n":"NCT05740527","t":"Ambulatory Closed-loop Stimulation for Bladder Control","d":"Individuals with spinal cord injury (SCI) develop neurogenic detrusor overactivity (NDO), resulting in urinary incontinence, decreased bladder capacity, and reduced quality of life. Current treatments incompletely address the problem and have unwanted side effects. Therefore, an alternative approach is needed. Electrical stimulation of the genital nerves (GNS) can inhibit NDO, improving bladder capacity and urinary continence. However, an automated closed-loop bladder feedback system, which…","s":"Completed","tr":["Devices","Electrical Stimulation"],"o":["Bladder Function","Quality of Life","Walking Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05740527"},{"n":"NCT04340063","t":"Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury","d":"Spinal cord injury (SCI) affects \\~42,000 Veterans. The VA provides the single largest network of SCI care in the nation. The lifetime financial burden of SCI can exceed $3 million. A major cost of SCI is impaired mobility. Limited mobility contributes to decreased ability to work, increased care requirements, secondary injury, depression, bone mineral density loss, diabetes, and decreased cardiovascular health. Among ambulatory individuals with iSCI, residual balance deficits are common and…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Bladder Function","Blood Pressure","Bone Strength","Leg Movement","Mental Health","Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04340063"},{"n":"NCT05700942","t":"AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI","d":"Locomotor training (LT) facilitates recovery of spinal locomotor networks after incomplete spinal cord injury (ISCI), but walking impairments persist. A limitation of LT is insufficient excitation of spinal locomotor circuits to induce neuroplastic recovery. Transcutaneous spinal direct current stimulation (tsDCS) is a non-invasive approach to increase spinal excitation and modulate spinal reflexes. The study will examine if tsDCS combined with LT enhances locomotor rehabilitation after ISCI.","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05700942","su":"https://scitrials.org/trial/NCT05700942"},{"n":"NCT04137159","t":"An Exercise Intervention to Reduce Neuropathic Pain and Brain Inflammation After Spinal Cord Injury","d":"Spinal Cord Injury (SCI) leads to alterations in brain structure and function by spinal nerve damage, secondary inflammatory responses, and by the consequences of living with paralysis and neuropathic pain. Physical inactivity due to lower body paralysis rapidly leads to loss of muscle, and risk of heart disease. The leading cause of death after a spinal cord injury is cardiovascular disease, and just a year after injury, those with SCI have a peak exercise capacity half that of the unfit…","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Blood Pressure","Mental Health","Pain Management","Quality of Life"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04137159"},{"n":"NCT03150017","t":"An Internet-Delivered Pain Management Programme for Spinal Cord Injury Pain","d":"To establish the effectiveness of an internet-delivered cognitive behavioural therapy pain management programme (CBT-PMP) on people with spinal cord injury pain compared with usual care.","s":"Unknown","tr":["Rehabilitation"],"o":["Pain Management"],"st":[],"co":["Ireland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03150017","su":"https://scitrials.org/trial/NCT03150017"},{"n":"NCT06583538","t":"An Online Rehabilitation Programme for People with SCI","d":"The goal of this feasibility study is to explore the feasibility and effectiveness of a 12-week online rehabilitation programme in people with Spinal Cord Injury during the transition from hospital to home. The main question\\[s\\] it aims to answer are: * What is the feasibility of an online rehabilitation programme to support physical activity adherence in people with spinal cord injury following discharge into the community? * How effective is an online rehabilitation programme to enhance…","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function","Quality of Life","Walking Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06583538"},{"n":"NCT04474171","t":"An Online Self-management Program for Spinal Cord Injury: Feasibility Study of SCI&U","d":"Managing a spinal cord injury (SCI) is a life-long process. Within the first year of injury, more than 50% of people discharged with a SCI may require re-hospitalization due to a secondary complication, such as a urinary tract infection, pressure ulcer or pneumonia. Even 20 years post-injury, re-hospitalization rates remain over 30%. While re-hospitalization rates in Canada have remained high for more than 10 years, the length of stay in inpatient rehabilitation has decreased dramatically…","s":"Completed","tr":["Rehabilitation"],"o":["Bladder Function","Mental Health","Pressure Sores","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04474171"},{"n":"NCT01202227","t":"An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain","d":"The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis pain).","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["Japan"],"lc":26,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01202227"},{"n":"NCT04285970","t":"Analysis of the Motion Activity Manual Wheelchair Users","d":"Currently, there is no system in place to allow manual wheelchair users to know their quantities of movement activities and the intensity of effort to be provided during these propulsion movements. Based on recent work by Routhier et al. in 2017, and in light of the scientific literature related to wheelchair propulsion, it would seem appropriate to validate the use of inertial units as tools to quantify and categorize the intensity of manual wheelchair propulsion.","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04285970"},{"n":"NCT05831163","t":"Analyzing Clinical Research Participation of Patients With Spinal Cord Injury","d":"The percentages of participants in clinical studies haven't always been perfectly representative of a particular group. This research examines the variables that affect a patient's choice to enroll in, discontinue participation in, or resume participation in a clinical trial for spinal cord injury. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future spinal cord injury research.","s":"Unknown","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05831163"},{"n":"NCT01683916","t":"Anesthetic Requirement and Stress Hormone Response During Surgery in Spinal Cord-injured Patients","d":"Spinal cord injury (SCI) reduces anesthetic requirements and stress hormonal responses. Anesthetic requirements and stress hormone response are compared in SCI patients undergoing anesthesia with sevoflurane supplemented with clinically equivalent doses of either N2O or remifentanil.","s":"Completed","tr":["Observational","Surgical Procedure"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01683916"},{"n":"NCT05881122","t":"Anti-inflammatory Diet Consultation for Those With Neuromuscular Disability","d":"This study investigated the effects of a 2-part dietary consultation on adherence to an anti-inflammatory diet in individuals with neuromuscular disability. The effects on self-efficacy for adhering to the diet as well as neuropathic pain and depression one month post-consult were also determined.","s":"Completed","tr":["Nutrition"],"o":["Mental Health","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05881122"},{"n":"NCT03200613","t":"Apixaban For Thromboprophylaxis In Patients With Acute Spinal Cord Injury","d":"Thromboprophylaxis options are limited for patients with acute spinal cord injury (SCI) and there are no studies on direct oral anticoagulants (DOACs) for thromboprophylaxis in this population. Participants will be randomized to apixaban 2.5 mg twice daily or standard dose low-molecular-weight heparin (LMWH), either enoxaparin 40 mg or dalteparin 5000 units, subcutaneously once daily for 90 days or until fully mobilized, whatever comes first. Thromboprophylaxis will be started as soon as…","s":"Terminated","tr":["Drugs"],"o":["Breathing Function","Leg Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03200613"},{"n":"NCT01112774","t":"Application of Transcranial Direct Current Stimulation (tDCS) in Patients With Chronic Pain After Spinal Cord Injury","d":"The purpose of this study is to determine whether the novel treatment of transcranial direct current stimulation (tDCS) could decrease the pain perception of those with spinal cord injury. We will also determine whether these changes are correlated with the clinical outcome (pain reduction).","s":"Terminated","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01112774"},{"n":"NCT03962218","t":"Aquatic Specific Physiotherapy on Incomplete Spinal Cord Injuries","d":"Purpose of the study: To analyse the effectiveness of aquatic physiotherapy on spinal cord injuries (LMi) in the improvement of balance and gait, in the inflammatory profile, and the impact on the quality of life. Main objective: To analyse if there are differences in the recovery of the balance, in incomplete subacute spinal cord injuries, with lesion level T1-L5 and ASIA (American Spinal Injury Association) C and D . Secondary objectives: 1. functional gait 2. To evaluate if the time from the…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03962218"},{"n":"NCT02774603","t":"Aquatic vs. Land Locomotor Training Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life","d":"The aim of this study is to define and evaluate the efficacy of Aquatic Locomotor Training (ALT) compared to overground Locomotor Training in improving ambulatory function and health-related quality of life. The investigators hypothesize, that Aquatic Locomotor Training is capable of producing outcomes that are as good as, or better than, overground Locomotor Training. Aquatic Locomotor Training may be another tool for therapists to utilize for clinical improvements in function and gait for the…","s":"Terminated","tr":["Rehabilitation"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02774603"},{"n":"NCT05941819","t":"ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury","d":"The goal of this interventional study is to evaluate the safety and preliminary effectiveness of the ARC-IM Therapy to improve hemodynamic management in people with sub-acute or chronic spinal cord injury. Participants will be implanted with the ARC-IM Thoracic System which aim to deliver, at the low thoracic level, targeted epidural electrical stimulation that will support natural hemodynamic control.","s":"Unknown","tr":["Epidural Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Netherlands"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05941819","su":"https://scitrials.org/trial/NCT05941819"},{"n":"NCT07147296","t":"ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury","d":"Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (\\>1 year after SCI). The primary effectiveness outcome will be evaluated through subject-reported ADFSCI and seated blood pressure assessments at 3 months post-implant. Following a baseline screening period and the surgical implantation of…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Blood Pressure"],"st":["Arkansas","Colorado","Florida","Georgia","Kentucky","Maryland","Massachusetts","Minnesota","New York","Oregon"],"co":["Canada","United States"],"lc":13,"rlc":13,"cu":"https://clinicaltrials.gov/study/NCT07147296","su":"https://scitrials.org/trial/NCT07147296"},{"n":"NCT07234903","t":"ARC-IM Therapy To Support and Promote Recovery of Ambulatory Functions in People With Subacute and Chronic Spinal Cord Injury","d":"The EIGER study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to support and promote recovery of ambulatory functions, such as walking, in people with subacute and chronic spinal cord injury.","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07234903","su":"https://scitrials.org/trial/NCT07234903"},{"n":"NCT05619146","t":"Arm and Leg Cycling for Accelerated Recovery From SCI","d":"The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in individuals with an incomplete spinal cord injury. The researchers hypothesize there will be improved walking function following motorized cycling.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05619146","su":"https://scitrials.org/trial/NCT05619146"},{"n":"NCT06873776","t":"Arm and Leg Cycling for Accelerated SCI Recovery","d":"The purpose of this study is to examine interventions with paradigms involving upper and lower extremity cycling (A\\&L cycling) with A\\&L cycling with functional electrical stimulation (FES) (A\\&L\\_FES group), A\\&L cycling with FES and transcutaneous Spinal Cord Stimulation (A\\&L\\_tSCS group), and control Body Weight Supported Treadmill Training (BWSTT) to potentially restore functional abilities (i.e., walking) in individuals with an incomplete spinal cord injury. The researchers hypothesize…","s":"Enrolling by invitation","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06873776","su":"https://scitrials.org/trial/NCT06873776"},{"n":"NCT02778529","t":"Arm Motor Control on Bi and Uni ADLs","d":"This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs. By studying the kinematics of the respective cohort of study participants as they are assessed performing common activities of daily living (ADLS), the investigators research team aims to better understand how impaired neural pathways, and pathways that have been…","s":"Terminated","tr":["Devices"],"o":["Arm Movement","Motor Function"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02778529"},{"n":"NCT02098135","t":"ArmeoSenso - Home Therapy and Assessment for Patients With Arm Impairments Based on Wearable Movement Sensors","d":"stroke, spinal cord injury, rehabilitation, home therapy, upper limb, arm, virtual reality, interia sensor, * Trial with medical device","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02098135"},{"n":"NCT07369349","t":"Artificial Int: Neurogenic Bowel Education in Spinal Cord Injury Patients","d":"The aim of this study is to evaluate the effectiveness of patient education delivered through an artificial intelligence (AI)-based mobile application in the management of neurogenic bowel dysfunction in individuals with spinal cord injury. Within the scope of the study, it will be examined whether the mobile application reduces neurogenic bowel scores, contributes to maintaining stool scores within the normal range, and improves the quality of life of individuals. Accordingly, the AI-based…","s":"Not yet recruiting","tr":[],"o":["Bowel Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07369349","su":"https://scitrials.org/trial/NCT07369349"},{"n":"NCT06436716","t":"Artificial Intelligence Model for Traumatic Cervical Spinal Cord Injury Based on Radiomics and Genomics","d":"Collect standardized, structured, and comprehensive disease-specific information, produce high-quality and accurate clinical data, provide a sample basis for the analysis and mining of spinal cord injury clinical big data, and establish a spinal cord injury-specific disease data platform to serve clinical work. Promote multi-center cooperation in spinal cord injury research: Establish a unified, standardized, queryable, and sharable efficient spinal cord clinical research data platform to…","s":"Recruiting","tr":["Observational"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06436716"},{"n":"NCT00667966","t":"Assess Efficacy in Subjects With Traumatic Spinal Cord Injury","d":"Assess efficacy of Vardenafil in patients with traumatic spinal cord injury","s":"Completed","tr":["Drugs"],"o":["Sexual Function"],"st":[],"co":["Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00667966"},{"n":"NCT03664479","t":"Assess the Safety and Efficacy of the 4 Channel NMES, Pilot Study","d":"This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders. The purpose of this study is to investigate the difference in effect by the electric stimulation method and to obtain the values such as mean, standard deviation and so on, and to determine the number of subjects to be studied for clinical trials of validation permission in the…","s":"Terminated","tr":["Devices","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03664479"},{"n":"NCT03518892","t":"Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury","d":"Assess the relationship between body composition, metabolism, and dietary needs in people with spinal cord injury compared to their healthy controls that are age and sex matched.","s":"Completed","tr":["Nutrition","Observational"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03518892"},{"n":"NCT07706517","t":"Assessing Transition Practices for Children With Disabilities: Pathways to a Successful Adulthood","d":"Transition to adult care is a purposeful and structured movement of youth with complex disabilities from child centered to adult oriented services. This complex and potentially challenging period requires careful planning. The investigators aim to examine the transition practices in the University Hospital of Saint Etienne. The study employs a mixed methods approach, combining: * A retrospective evaluation : Analyzing transition data over a 10-year period. * A prospective qualitative study …","s":"Completed","tr":["Observational"],"o":["Quality of Life","Spasticity"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07706517"},{"n":"NCT05615766","t":"Assessment of a Robotic Exoskeleton for Upper Limb Rehabilitation","d":"Rehabilitation robotics has the potential to facilitate rehabilitation at home and empower people with spinal injuries to self-manage increasing their independence and improving their quality of life. The objective of this study is to assess for the first time in the NHS the efficacy of a commercial robotic orthosis for upper limb rehabilitation in patients with spinal cord injury. The device is produced by Myomo (myomo.com) which is an American company. We will be assessing the wearable…","s":"Recruiting","tr":["Exoskeleton","Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05615766","su":"https://scitrials.org/trial/NCT05615766"},{"n":"NCT06533969","t":"Assessment of Neural Signals for the Control of Assistive Devices","d":"The study will investigate the use of motor intention-based cortical signals to trigger epidural spinal cord stimulation (ESCS) with individuals with SCI. Motor intention of UL tasks will be decoded using brain-computer interface (BCI) system based on cortical signals recorded using an Electroencephalographic (EEG) system or using their intracranially implanted devices Electrocorticographic (ECoG).","s":"Recruiting","tr":["Brain Stimulation","Epidural Stimulation"],"o":["Hand Movement"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06533969","su":"https://scitrials.org/trial/NCT06533969"},{"n":"NCT02138344","t":"Assessment of Neuropathic Pain","d":"Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases. The functionality of the pain pathway in humans as well as its plastic changes following SCI can be assessed in vivo by surface electrophysiological recordings and functional magnetic resonance imaging after noxious heat stimulation of the skin. Aims: a) establishing a clinically applicable assessment of the pain pathway and characterizing its changes as a…","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02138344"},{"n":"NCT03914456","t":"Assessment of Neurorehabilitation in Spinal Cord Injury Using Neuroimage Tools.","d":"The sensorimotor cortex may play a role in the functional recovery after Spinal Cord Injury (SCI) through efference generated in the absence of the afference. OBJECTIVE: The purpose of this study was to evaluate the potential reorganization in the sensorimotor cortex in SCI patients after Body Weight Supported Treadmill Training (BWSTT) associated with conventional motor rehabilitation. METHOD: Seven SCI patients with ASIA C and D participated in this study. They were submitted to a motor-task…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03914456"},{"n":"NCT07396922","t":"Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments","d":"This study will evaluate the safety and performance of the Spatial StimeMD (SSMD) medical device in people with multiple sclerosis (MS). The SSMD device is intended to support patients through a non-invasive stimulation program. The study will assess changes in MS-related symptoms and physical function using clinical assessments and patient-reported outcomes.","s":"Not yet recruiting","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Poland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07396922"},{"n":"NCT05094752","t":"Assessment of the Effects of Early Proprioceptive Stimulations in Patients With Spinal Cord Injury","d":"\"Spinal cord injury (SCI) is a dramatic event resulting in a long-term handicap. Appropriate care from admission to the intensive care unit (ICU) is a key element not only for the survival of these patients but also to promote their recovery. Moreover, the studies on natural history of SCI have shown that most of the recovery occurs within the first 3 to 6 months post-injury. This period is therefore crucial for these patients. However, the environment of the ICU and the acute condition of the…","s":"Unknown","tr":[],"o":["Spasticity"],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05094752","su":"https://scitrials.org/trial/NCT05094752"},{"n":"NCT04496609","t":"Assessment of the Efficacy and Safety of EESS in Patients With Incomplete Spinal Cord Injuries","d":"Neurological disability caused by traumatic lesions of the spinal cord is a significant challenge for medicine and society. These lesions, leading to sublesional central nervous system dysfunction, include sensorimotor, vesico-sphincter and genito-sexual disorders. To date, there is no treatment that enables spinal cord function to be restored. Preclinical studies have been able to demonstrate the recovery of locomotor activity with a combination of locomotor training, pharmacological…","s":"Recruiting","tr":["Electrical Stimulation","Epidural Stimulation","Rehabilitation"],"o":["Quality of Life","Sexual Function","Walking Function"],"st":[],"co":["France"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT04496609"},{"n":"NCT04215939","t":"Assessment of Vasomotion of People With Spinal Cord Injury","d":"Spinal cord injury (SCI), causes loss of supra-spinal control of the sympathetic nervous system and in some cases loss of sensation. As a result, people with SCI have impaired thermoregulatory system and the consequence of this thermoregulatory dysfunction, is that they cannot respond to the environmental changes. All the above lead to dysregulation in vasomotor tone, skeletal muscle shivering and sweating dysfunction. It is well known that skin plays an important role in regulating body…","s":"Completed","tr":[],"o":["Blood Pressure","Hand Movement","Sensory Function","Temperature Control"],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04215939"},{"n":"NCT05459207","t":"Association Between Body Composition and Pain in Spinal Cord Injury","d":"The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05459207","su":"https://scitrials.org/trial/NCT05459207"},{"n":"NCT02562001","t":"Association Between tDCS and Lokomat Training in Patients With Incomplete Spinal Cord Injury","d":"The spinal cord injury is identified as the major cause of permanent disability worldwide, with the loss of ability to walk being the largest and most devastating of them for these patients. Our goal is to analyze the effects of electrical transcranial direct-current stimulation (tDCS) combined with gait training with partial body weight support aided by robotic device (Lokomat, Hocoma) in the gait of patients with incomplete spinal cord injury (SCI). In this stratified randomized double-blind…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02562001"},{"n":"NCT05236933","t":"Association Between Types of Pain and Motor Activities Physical Activity","d":"This study will investigate the relationships between: (1) physical activity (PA) and types of chronic pain (nociceptive and neuropathic), and (2) virtual reality (VR) and types of chronic pain (nociceptive and neuropathic).","s":"Completed","tr":["Observational"],"o":["Mental Health","Pain Management"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05236933"},{"n":"NCT03886610","t":"Association of Quantitative and Functional Imaging With Clinical Outcome After Spinal Cord Injury","d":"The overall study aim is to provide additional magnetic resonance imaging parameters of the cervical spinal cord, brainstem and brain and a better understanding of changes after spinal cord injury (SCI) and to define new magnetic resonance (MR) biomarkers to correlate with sensomotoric functioning and clinical outcome.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03886610"},{"n":"NCT06836739","t":"At-Home Genital Nerve Stimulation for SCI Bowel","d":"The purpose of this study is to test whether electrical stimulation of the skin in the pelvic area (near the genitals) can reduce the reflexes that cause bowel accidents in people with spinal cord injuries. Current bowel treatments either involve diet and medications or surgery. This study will evaluate whether electrical stimulation can be an alternate option for bowel management. Researchers will: * Use an FDA approved Transcutaneous Electrical Nerve Stimulation (TENS) device off-label *…","s":"Recruiting","tr":[],"o":["Bowel Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06836739","su":"https://scitrials.org/trial/NCT06836739"},{"n":"NCT07209943","t":"Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro","d":"The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI) or spinal cord injury (SCI) that have assistive communication and computer control needs. Each subject will receive an integrated Cognixion + Apple Vision Pro device that includes an augmented reality brain computer interface and associated communication software. The…","s":"Not yet recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07209943"},{"n":"NCT04309448","t":"Augmenting Reactive Stepping With FES After SCI","d":"Up to 25 individuals living with chronic incomplete spinal cord injury (iSCI) who can stand but have limited ability to elicit a step without physical assistance or upper limb (U/L) support will be recruited for this study. The first objective of the study will aim to investigate the orthotic effect (i.e., immediate effect) of FES on the reactive stepping response. The second objective is to investigate the therapeutic effect of a novel balance intervention, perturbation-based balance training…","s":"Completed","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04309448"},{"n":"NCT06225245","t":"Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord","d":"The goal of this study is to investigate the effects of cervical epidural spinal stimulation with upper extremity training. This is an investigational study. The device used for epidural spinal stimulation (ESS) to deliver spinal stimulation is called the CoverEdgeX 32 Surgical Lead system. This device is approved by the Food and Drug Administration (FDA) for the treatment of severe pain and to manage chronic pain when other treatments have not been effective. In this study, the device is…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06225245","su":"https://scitrials.org/trial/NCT06225245"},{"n":"NCT06700278","t":"Auricular Acupressure and Limb Massage for Neuropathic Pain in Spinal Cord Injury","d":"This randomized controlled trial included 90 patients with spinal cord injury, divided into an experimental group and a control group (45 each). The experimental group received auricular acupressure alongside rehabilitation therapy, while the control group received body acupoint massage alongside rehabilitation therapy. The intervention targeted specific auricular and body acupoints, performed three times daily, five days a week, for three weeks.","s":"Not yet recruiting","tr":[],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06700278","su":"https://scitrials.org/trial/NCT06700278"},{"n":"NCT06588608","t":"Auricular Vagus Nerve Stimulation (aVNS) in Chronic Spinal Cord Injuries (SCI)","d":"The purpose of this research is to test if Auricular Vagal Nerve Stimulation (aVNS) is safe in persons with spinal cord injury (SCI).","s":"Completed","tr":["Devices"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06588608"},{"n":"NCT02493543","t":"Autoantibodies on Spinal Cord Injury","d":"The purpose of this study is to determine the autoantibody profiles after spinal cord injury and their role in spontaneous functional recovery.","s":"Unknown","tr":["Observational"],"o":["Motor Function","Sensory Function"],"st":[],"co":["Germany","Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02493543","su":"https://scitrials.org/trial/NCT02493543"},{"n":"NCT04211636","t":"Autoimmunity And Immune Deficiency After Spinal Cord Injury: Association With Rehabilitation Outcomes","d":"The SCIentinel-prolong study systematically analyzes humoral autoantibody responses and thier interaction with post-spinal cord injury (SCI) immune-deficiency and infections as well as their association with the clinical course of rehabilitation. Therefore, molecular and immunological tests in blood and cerebrospinal fluid specimen are combined with clinical outcomes ranging from neurological function, neuropathic pain and spasticity to walking tests and measures of independence in daily living…","s":"Unknown","tr":["Observational","Rehabilitation"],"o":["Arm Movement","Leg Movement","Motor Function","Pain Management","Quality of Life","Sensory Function","Spasticity","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04211636","su":"https://scitrials.org/trial/NCT04211636"},{"n":"NCT04520373","t":"Autologous Adipose Derived Mesenchymal Stem Cells for Spinal Cord Injury Patients","d":"The purpose of this research study is to investigate the safety and potential therapeutic effects of autologous, culture-expanded, adipose derived mesenchymal stem cell intrathecal injections in the treatment of spinal cord injury.","s":"Active, not recruiting","tr":[],"o":["Regeneration"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04520373","su":"https://scitrials.org/trial/NCT04520373"},{"n":"NCT01274975","t":"Autologous Adipose Derived MSCs Transplantation in Patient With Spinal Cord Injury.","d":"This study is designed to assess the safety of intravenous autologous adipose derived mesenchymal stem cells transplant in spinal cord injury patients.","s":"Completed","tr":["Drugs","Stem Cells"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01274975"},{"n":"NCT02260713","t":"Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study.","d":"Pilot study on 7 subjects in each group (total 21 subjects) to establish the safety and feasibility of autologous bone marrow cell transplantation in case of acute complete spinal cord injury by each of the following techniques and a corresponding number of controlled subjects: * Directly into the injured site with a syringe after exposing the spinal cord. * By Intrathecal injection.","s":"Completed","tr":["Safety","Stem Cells"],"o":["Bladder Function","Mental Health","Motor Function","Spasticity"],"st":[],"co":["India"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02260713"},{"n":"NCT01325103","t":"Autologous Bone Marrow Stem Cell Transplantation in Patients With Spinal Cord Injury","d":"This research investigates the use of autologous bone marrow stem cells in patients with spinal cord injury.","s":"Completed","tr":["Stem Cells"],"o":["Motor Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01325103"},{"n":"NCT05671796","t":"Autologous Bone Marrow Stem Cell Transplantation in Patients With Subacute Spinal Cord Injury","d":"The aim of this study is to evaluate the efficacy and safety of intrathecal administration of autologous mesenchymal stem cells in participants with subacute spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05671796","su":"https://scitrials.org/trial/NCT05671796"},{"n":"NCT01572376","t":"Autologous Bone Marrow Stem Cells in Pressure Ulcer Treatment","d":"The aim of the study is to determine the safety and feasibility of an autologous mononuclear stem cells infusion in pressure ulcers of paraplegic patients; and moreover, to evaluate the efficacy of the treatment.","s":"Completed","tr":["Safety"],"o":["Pressure Sores"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01572376"},{"n":"NCT04528550","t":"Autologous Bone Marrow-derived Mononuclear Cells for Acute Spinal Cord Injury","d":"The purpose of this study is to evaluate the safety and effectiveness of intrathecal transplantation of autologous bone marrow-derived mononuclear cells for the treatment of traumatic acute spinal cord injury. Spinal cord injury can be divided into three phases, which are acute (within 2 weeks), sub-acute (2 weeks to 6 months), and chronic (over 6 months). Early treatment is the key to improve the prognosis, however, the majority of clinic trails nowadays are focusing on sub-acute or chronic…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04528550","su":"https://scitrials.org/trial/NCT04528550"},{"n":"NCT03933072","t":"Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection","d":"The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with simultaneous reconstruction of the posttraumatic spinal cord gap with peripheral nerve grafts, in patients with chronic complete spinal cord injury. The treatment will be performed in two patients that have sustained an anatomically complete spinal cord transection between…","s":"Unknown","tr":[],"o":["Regeneration","Walking Function"],"st":[],"co":["Poland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03933072","su":"https://scitrials.org/trial/NCT03933072"},{"n":"NCT00073853","t":"Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries","d":"Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function. Following non-CNS tissue injury, macrophages quickly arrive on the scene, where they clean up cell debris, secrete different molecules thus promoting a controlled inflammatory reaction that forms the first phase of the wound healing process. While this process occurs in most tissues, including…","s":"Suspended","tr":[],"o":["Bladder Function","Bowel Function","Sensory Function"],"st":["Colorado","Georgia","New Jersey","New York","Pennsylvania"],"co":["Israel","United States"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00073853"},{"n":"NCT01694927","t":"Autologous Mesenchymal Stem Cells in Spinal Cord Injury (SCI) Patients","d":"The aim of this study is to evaluate the use of autologous expanded mesenchymal stem cells intralesional transplantation as a safe and potentially beneficial treatment for patients with spinal cord injury.","s":"Unknown","tr":["Stem Cells"],"o":["Motor Function","Spasticity"],"st":[],"co":["Chile"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01694927"},{"n":"NCT02482194","t":"Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study","d":"The conventional treatment of spinal cord injury (SCI) includes physical therapy and rehabilitation and in some cases may require surgical intervention. Although improved emergency care and aggressive treatment can help in preventing further damage and even restore minimal sensory functions, still a large proportion of patients suffer with prolonged disabilities. It led neurologists to search out for new treatment options for this otherwise debilitating disorder. Recent advances in research…","s":"Completed","tr":["Drugs","Rehabilitation","Stem Cells","Surgical Procedure"],"o":["Motor Function","Quality of Life","Regeneration","Sensory Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02482194"},{"n":"NCT02574572","t":"Autologous Mesenchymal Stem Cells Transplantation in Cervical Chronic and Complete Spinal Cord Injury","d":"The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with cervical chronic and complete spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Brazil"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02574572","su":"https://scitrials.org/trial/NCT02574572"},{"n":"NCT02574585","t":"Autologous Mesenchymal Stem Cells Transplantation in Thoracolumbar Chronic and Complete Spinal Cord Injury Spinal Cord Injury","d":"The purpose of this study is to analyze the safety and efficacy of autologous bone marrow mesenchymal stem cell transplantation in patients with thoracolumbar chronic and complete spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02574585","su":"https://scitrials.org/trial/NCT02574585"},{"n":"NCT01328860","t":"Autologous Stem Cells for Spinal Cord Injury (SCI) in Children","d":"The purpose of this research study is: 1. To see if Bone Marrow Cell harvest and transplantation are safe in children with Spinal Cord Injury, and 2. To determine if late functional outcome is improved following Bone Marrow Cell transplantation in children with Spinal Cord Injury, using pre-transplantation spinal cord function as the control.","s":"Terminated","tr":["Stem Cells"],"o":["Pain Management"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01328860"},{"n":"NCT06211491","t":"Autonomic Dysreflexia in Spinal Cord Injuries: UDS Filling Speed Impact","d":"In patients with spinal cord injury, the investigators want to understand and understand the differences in AD prevalence and characteristics according to bladder injection rate, and to determine which factors have a greater influence between bladder expansion or injection rate.","s":"Recruiting","tr":["Observational"],"o":["Bladder Function","Blood Pressure"],"st":[],"co":["South Korea"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06211491","su":"https://scitrials.org/trial/NCT06211491"},{"n":"NCT01059370","t":"Autonomic Dysreflexia in Spinal Cord Injury","d":"Autonomic dysreflexia in high spinal cord-injured can be initiated by a full bladder or bowel, or when trying to empty either. This randomised study aims at evaluating whether irrigation procedure or digital stimulation or evacuation of the rectum is less provocative of autonomic dysreflexia. Participants have their bowels emptied on different days, in the morning fasting. Bladder filling with sterile saline water is evaluated on a third day as a control.","s":"Completed","tr":[],"o":["Bladder Function","Blood Pressure","Bowel Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01059370"},{"n":"NCT05960448","t":"Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury","d":"The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal cord injury community. The main questions it aims to answer are: * What are the effects of active TSCS targeted for BP control on exercise endurance time and HR recovery during submaximal arm cycle ergometry (ACE) as compared to sham TSCS in participants with chronic…","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05960448","su":"https://scitrials.org/trial/NCT05960448"},{"n":"NCT05664646","t":"Autonomic Effects of Stimulation in SCI","d":"This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment.","s":"Completed","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05664646","su":"https://scitrials.org/trial/NCT05664646"},{"n":"NCT04618003","t":"Autonomic Modulation in Athletes and Non-Athletes With Spinal Cord Injury During Task in Virtual Reality Environment","d":"The study consisted in the analysis of the autonomic modulation of the heart rate by the Heart Rate Variability of the participants at rest for 5 minutes, and during physical activity of 8 minutes, through a virtual reality game. The data capture was performed using a cardio-frequency meter with belt placed on the volunteer's trunk and, in addition, questionnaires, functional classification scales and personal data collection were applied.","s":"Completed","tr":["Observational"],"o":["Trunk Control"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04618003"},{"n":"NCT03169582","t":"Avanafil Versus Sildenafil in Spinal Cord Injury Erectile Dysfunction","d":"The main goal of this study is to compare the use of Avanafil versus Sildenafil in spinal cord injury erectile dysfunction. The study has the characteristics of a non- inferiority, randomized, crossover, open clinical trial. The principal variable is the IIEF-EF (Erectile Function Domain questionnaire of the International Index of Erectile Function IIEF). This is an interventional study","s":"Unknown","tr":["Drugs"],"o":["Sexual Function"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03169582","su":"https://scitrials.org/trial/NCT03169582"},{"n":"NCT06661057","t":"Avation Electric Stimulation System for Spinal Cord Injury Neurogenic Bladder","d":"The purpose of this study is to assess and optimize the Avation electric stimulation system output and electromyography (EMG) processing to stimulate the tibial nerve in people with chronic Spinal Cord Injury (SCI) who have foot muscle atrophy and edema, both of which may affect proper device operations, to evaluate the safety, feasibility, and effectiveness of Avation Electric Stimulation System for bladder neuromodulation in people with SCI and identify barriers to implementation of the…","s":"Withdrawn","tr":["Devices","Electrical Stimulation"],"o":["Bladder Function","Bowel Function","Pain Management","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06661057"},{"n":"NCT03989440","t":"AXER-204 in Participants With Chronic Spinal Cord Injury","d":"This two-part trial will assess the safety, tolerability, pharmacokinetics, and efficacy of AXER-204 administered by lumbar puncture and slow bolus infusion. Part 1 will evaluate the safety, tolerability, and pharmacokinetics of single ascending doses of AXER-204. Part 2 will evaluate the safety, tolerability, pharmacokinetics, and efficacy of repeated doses AXER-204 in comparison to placebo.","s":"Completed","tr":["Drugs"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":["California","Georgia","Illinois","Massachusetts","Ohio","Pennsylvania"],"co":["United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03989440"},{"n":"NCT06559618","t":"Bacteriophage Therapy in Spinal Cord Injury Patients With Bacteriuria","d":"This is a Phase 1b study to assess the safety, tolerability, PK, and PD of investigational phage therapy (IP) in adults with SCI and bladder colonization (ASB). It is a single-center, randomized, double-blind, placebo-controlled study in adults with SCI with neurogenic bladders and bacteriuria who use indwelling catheters, or who require intermittent catheterization for bladder drainage.","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":["Missouri","Texas"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06559618","su":"https://scitrials.org/trial/NCT06559618"},{"n":"NCT01599455","t":"Baseline Cardiovascular Measurements in Pediatric Spinal Cord Injury","d":"Following spinal cord injury (SCI), the body loses normal control of blood pressure and heart rate, and there is a risk of sudden and dangerous increases in blood pressure, namely, autonomic dysreflexia (AD). It is important to be aware of baseline blood pressures and heart rates in individuals in order to detect AD. However, baseline values vary in developing children, and may be more variable in children with SCI. Thus, the objective of this study is to determine baseline blood pressure and…","s":"Completed","tr":["Observational"],"o":["Bladder Function","Blood Pressure"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01599455"},{"n":"NCT00652262","t":"BAY38-9456 - Supportive Trial for Spinal Injury","d":"BAY 38-9456 10 mg and 20 mg can be given as safe and efficacious medications to patients with spinal cord injury suffering from erectile dysfunction, and that erectile dysfunction can be improved by uptitration to BAY 38-9456 20 mg when the treatment with 10 mg is not sufficiently effective","s":"Completed","tr":["Drugs"],"o":["Sexual Function"],"st":[],"co":["Japan"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00652262"},{"n":"NCT01852279","t":"BCI and FES for Hand Therapy in Spinal Cord Injury","d":"This study will assess whether functional recovery of the hand muscles in patients with spinal cord injury is enhanced when electrical stimulation of the muscles is delivered actively by means of using the electroencephalography wave patterns arising from the patient imagining moving their hand to operate the stimulator. A control group will obtain the electrical stimulation treatment passively by a therapist operating the machine.","s":"Completed","tr":["Brain Machine Interface (BMI)","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Motor Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01852279"},{"n":"NCT06939660","t":"BCI-Assisted SCS-EXS for Gait Optimization","d":"The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury (SCI). The primary aim is to determine whether the BCI-SCS-EXS system can safely and effectively improve lower limb motor function and quality of life in individuals with chronic SCI. Participant Population: Adults aged 14-65 years (sex/gender not limited). Patients…","s":"Recruiting","tr":["Brain Stimulation","Epidural Stimulation","Exoskeleton"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06939660","su":"https://scitrials.org/trial/NCT06939660"},{"n":"NCT07768930","t":"BCI-Guided Tibialis Anterior FES for Gait Training in Spinal Cord Injury","d":"This study aims to investigate the effectiveness of Brain-Computer Interface (BCI)-guided Functional Electrical Stimulation (FES) in improving muscle activation and gait kinematics in individuals with Spinal Cord Injury (SCI).","s":"Active, not recruiting","tr":["Brain Machine Interface (BMI)","Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07768930"},{"n":"NCT04604951","t":"Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury","d":"Recent findings have demonstrated that electrical stimulation to the spinal cord (i.e. implanted electrodes) can significantly recover bladder, bowel, and sexual function after injury. While promising, a major drawback is that individuals must undergo a highly invasive and expensive surgical procedure to implant the stimulator on top of the spinal cord. Moreover, the inability to re-position the implanted stimulator considerably limits the flexibility of this procedure. In this project, the…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Sexual Function"],"st":[],"co":["Canada"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04604951","su":"https://scitrials.org/trial/NCT04604951"},{"n":"NCT00221117","t":"Benefits of Applying Neuroprosthesis to Improve Grasping and Reaching in Spinal Cord Injury Patients","d":"Functional electrical stimulation is a process that uses low intensity electrical pulses generated by an electric stimulator to create muscle contractions. By contracting muscles in a specific sequence, one can generate various body functions such as grasping, walking, and standing.The study is designed to evaluate the effectiveness and long term benefits of applying functional electrical simulation during early rehabilitation to improve grasping function in persons who have suffered a spinal…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Hand Movement","Quality of Life","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00221117"},{"n":"NCT02604927","t":"Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury","d":"Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines. Previous studies from our group have shown that upper-body exercise is very sensitive to the ergogenic effects of β-alanine supplementation and to other nutritional supplements capable of increasing buffering capacity. In line with this, have shown that upper-body muscle groups benefit more from…","s":"Unknown","tr":["Drugs"],"o":[],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02604927","su":"https://scitrials.org/trial/NCT02604927"},{"n":"NCT01407341","t":"Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer","d":"This pilot clinical trial studies beta-tricalcium phosphate bone graft in treating patients undergoing surgery for metastatic spine cancer. A bone graft may help healing and bone growth in patients undergoing surgery for spine cancer","s":"Terminated","tr":["Surgical Procedure"],"o":["Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01407341"},{"n":"NCT02700178","t":"Biofeedback for Wheelchair Users","d":"This study will evaluate movement of the arm and forces put through the hand during activities performed in a manual wheelchair. The goal of this study is to identify what motions and forces are most likely to lead to the development of pain or pathology and determine the feasibility of strategies to modify movements and decrease risk.","s":"Completed","tr":[],"o":["Pain Management","Trunk Control"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02700178"},{"n":"NCT03975075","t":"Biofeedback Treatment of Anxiety Associated With Chronic Spinal Cord Injury","d":"The purpose of this research is to test the feasibility of an intervention using biofeedback to treat stress and anxiety among individuals with tetraplegia. The expected duration of participation in this study is about 5 hours over the course of about 5 weeks. Participants will be randomly assigned to either a biofeedback training intervention or a control group. After completing questionnaires, participants will undergo physiological monitoring for the purpose of measuring heart rate and…","s":"Completed","tr":[],"o":["Breathing Function","Mental Health","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03975075"},{"n":"NCT06011876","t":"BioFLO for Respiratory Recovery in SCI","d":"Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (\\~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related…","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06011876","su":"https://scitrials.org/trial/NCT06011876"},{"n":"NCT00913471","t":"Biomarkers for Pain in Spinal Cord Injury Patients","d":"The investigators propose to compare plasma protein profiles for SCI patients with/without chronic neuropathic pain in order identify biomarker(s) that are associated with this medical condition. Secondly, the investigators propose to identify a temporal relationship to initial SCI at which these biomarkers manifest. Our working hypothesis is that sustained alterations in specific inflammatory molecules are associated with chronic neuropathic pain following SCI, and that their plasma levels can…","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00913471"},{"n":"NCT02761707","t":"Biomarkers in Neural Disorders","d":"This study seeks to establish the sensitivity and specificity of what appears to be a unique brainstem biomarker of Parkinson's Disease (PD) - an electrically induced olygosynaptic nasotrigeminal reflex response - in differentiating early stage PD from normal controls and from patients with various other neurodegenerative diseases. This study will additionally compare the biomarker to olfactory testing.","s":"Completed","tr":["Drugs","Observational"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02761707"},{"n":"NCT02731027","t":"Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury","d":"The purpose of the study is to profile biochemical responses and measure functional recovery in parallel, throughout the 1st year after spinal cord injury (SCI), within the same participants. These responses and recovery will be evaluated in samples from people who have had a spinal cord injury due to trauma (e.g. car accident or a fall) within the first year after SCI. Specifically, the investigators will test the hypothesis that a subset of inflammatory biomarkers correlate inversely with…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":["Kentucky","New Jersey","New York","Ohio","Pennsylvania"],"co":["Canada","United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02731027"},{"n":"NCT01183546","t":"Biomechanical Validation of the Transfer Assessment Instrument (TAI)","d":"The purpose of this research study is to further develop and refine the Transfer Assessment Instrument (TAI). The TAI is a clinical tool to be used by therapists to evaluate transfer techniques and performance.","s":"Completed","tr":["Observational"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01183546"},{"n":"NCT00645567","t":"Biomechanics of Wheelchair Transfers","d":"This is a laboratory-based study to evaluate the risk of shoulder injury associated with transfers between wheelchair and vehicle in persons with spinal cord injury. Four new devices will be compared against an unassisted transfer.","s":"Completed","tr":["Devices","Observational"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00645567"},{"n":"NCT00262457","t":"BIONs, for Improved Tissue Health and Pressure Sore Prevention","d":"The purpose of this study was to determine the feasibility of an implanted electrical stimulation system incorporating BION microstimulators for long term use to prevent tissue breakdown in high risk patients.","s":"Withdrawn","tr":["Electrical Stimulation"],"o":["Pressure Sores"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00262457"},{"n":"NCT04889092","t":"Blood Flow Restriction Exercise for Those With SCI","d":"Spinal cord injuries (SCI) are among the most debilitating conditions an individual can sustain with the estimates of SCI incidence in the United States at 12,000 new cases per year. The loss of innervation to the tissues muscle below the level of the lesion results in reduced physical activity which leads to an array of secondary complications including muscle atrophy, cardiovascular and metabolic disease, obesity and vascular dysfunction. This further leads to exercise intolerance, reduced…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Leg Movement","Mental Health","Motor Function","Quality of Life"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04889092"},{"n":"NCT05425238","t":"Blood Flow Restriction Resistance Exercise in Lower Cervical Spinal Cord Injury Patients","d":"This study is conducted to investigate the effects of low load Blood Flow Resistance exercise to improve strength and transfer in lower cervical spinal cord injury patientsCervical Spinal Cord injury patients have very less window of opportunity towards functional mode of life. In complete cervical spinal cord injuries only few muscles of upper limb are completely innervated and it is a need to gain maximum output and advantage out of that. Through conventional strength training it is possible…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Motor Function","Spasticity"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05425238"},{"n":"NCT06907381","t":"Blood Flow-restricted Resistance Exercise to Promote Muscle Strength and Use in Adults With Incomplete Spinal Cord Injury","d":"Recovery of arm and hand motor control is critical for independence and quality of life following incomplete spinal cord injury (iSCI). Blood flow-restricted resistance exercise (BFRE) has emerged as a potential treatment addressing this need, but treatment guidelines and research reporting effectiveness are sparse. The purpose of this work is to provide case reports of people with cervical iSCI who use BFRE supplemented by electrical stimulation (ES) to increase the strength and functional use…","s":"Completed","tr":["Electrical Stimulation","Observational"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":["Nebraska"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06907381","su":"https://scitrials.org/trial/NCT06907381"},{"n":"NCT01498809","t":"Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury","d":"This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investigators will examine key physiological components influencing orthostatic tolerance. The investigators will do this, by measuring the baroreflex, and brain blood flow…","s":"Completed","tr":["Drugs","Observational"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01498809"},{"n":"NCT02307565","t":"Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury","d":"Following spinal cord injury autonomic regulation of the cardiovascular system is impaired, which results in a variety of measurable abnormalities in blood pressure. Evidence of causality has been documented in the general medical literature with findings of improved cognitive function following acute increases in blood pressure using the anti-hypotensive agent Midodrine Hydrochloride (midodrine). Additionally, a recent report documented an inverse association between blood pressure and…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Mental Health"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02307565"},{"n":"NCT00957762","t":"Body Composition Assessment in Spinal Cord Injury","d":"The purpose of this research is to evaluate different methods of measuring body composition (amount of fat, muscle, bone, and water in your body) and to determine relationships between body composition and other medical problems associated with spinal cord injury (SCI).","s":"Unknown","tr":["Observational"],"o":[],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00957762","su":"https://scitrials.org/trial/NCT00957762"},{"n":"NCT06794242","t":"Body Representation and Neuropathic Pain in Spinal Cord Injury","d":"Chronic pain is one of the main complications of spinal cord injury, has a very negative impact on quality of life, and persists over time despite the use of analgesic treatments. Several types of pain are possible in patients with spinal cord injury, and neuropathic pain (pain caused by damage to the spinal cord, in this case) is one of the most difficult to treat, even with medication. Following an injury to the spinal cord, it is possible for the representation of the body to change as a…","s":"Not yet recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["France"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06794242","su":"https://scitrials.org/trial/NCT06794242"},{"n":"NCT01822535","t":"Body Temperature in Persons With Tetraplegia When Exposed to Cold","d":"The ability to maintain normal body core temperature (Tcore = 98.6°F) is impaired in persons with tetraplegia. Despite the known challenges to the ability of persons with spinal cord injury (SCI) to maintain Tcore, and the effects of hypothermia to impair mental function in able-bodied (AB) persons, there has been no work to date addressing these issues in persons with tetraplegia. The aim of this study is to determine if exposure of up to 2 hrs to cool temperatures (64°F) causes body core…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01822535"},{"n":"NCT01890915","t":"Body Temperature in Persons With Tetraplegia When Exposed to Heat","d":"The deleterious effects of hyperthermia are well appreciated in able-bodied persons. However, the consequences of impaired regulation of normal body temperature on cognitive performance of persons with tetraplegia is not known. This study will provide the preliminary findings necessary for future work to design and explore physical and medical interventions to improve temperature regulation in those with tetraplegia with the goal of improved clinical care, health, and quality of life. The…","s":"Completed","tr":["Observational"],"o":["Mental Health","Quality of Life","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01890915"},{"n":"NCT02703883","t":"Body Weight Support in Spinal Cord Injury","d":"The purpose of this study was to evaluate the effectiveness of body weight-supported treadmill (BWST) training on static balance impairment in adults with incomplete spinal cord injury (SCI) in chronic stage","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Trunk Control","Walking Function"],"st":[],"co":["Chile"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02703883"},{"n":"NCT03534518","t":"Body Weight Supported Training Study","d":"Successful ambulation at home and in the community is the main goal of gait training after incomplete spinal cord injury. Many different treatment approaches have been recommended to achieve this goal. One established intervention to achieve that in a clinical setting is body weight supported (BWS) treadmill training. However, recent studies have suggested that the most optimal gait training should be conducted overground with appropriate support conditions to enable a physiological gait…","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03534518","su":"https://scitrials.org/trial/NCT03534518"},{"n":"NCT02031835","t":"Body Weight Supported Treadmill Training as Physical Therapy Treatment to Spinal Cord Injury Patients","d":"The purpose of this current prospective study is to assess the effects of body weight support treadmill training (BWSTT) in individuals with spinal cord injury (SCI). Training intervention aim at improving: quality of life, walking capability, spasticity, functions in every day life, bone mass density and related hematological factors. The examination consisted of (1) neurological classification by ASIA standard neurological classification of spinal cord injury working sheet, (2) spasticity…","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Bone Strength","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02031835"},{"n":"NCT04641793","t":"BoMI for Muscle Control","d":"People with spinal cord injury (SCI), stroke and other neurodegenerative disorders can follow two pathways for regaining independence and quality of life. One is through clinical interventions, including therapeutic exercises. The other is provided by assistive technologies, such as wheelchairs or robotic systems. In this study, we combine these two paths within a single framework by developing a new generation of body-machine interfaces (BoMI) supporting both assistive and rehabilitative…","s":"Unknown","tr":["Brain Stimulation","Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04641793","su":"https://scitrials.org/trial/NCT04641793"},{"n":"NCT02118740","t":"Bone Marrow Collection in Healthy Volunteers (iCell)","d":"This is a observational study in which healthy found volunteers are recruited to donate 50 ml of bone marrow aspirate to enable preclinical studies to obtain proof of concept and safety of a bone marrow derived stem cell preparation named AMARCELL. The prepared AMARCELL is only for animal studies and after completion of the preclinical program, the intention of AMARCELL is to treat humans with a traumatic Spinal cord injury.","s":"Unknown","tr":["Observational","Stem Cells"],"o":[],"st":[],"co":["Netherlands"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02118740"},{"n":"NCT03307954","t":"Bone Mineral Density Ekso Therapy Study","d":"Spinal cord injury (SCI) leads to rapid and profound bone loss with large decreases in bone mineral density (BMD) below the level of the lesion. Decreases in BMD of \\~2% per month from the lower limbs have been reported and rates of loss are maximal over the first two years. As a consequence, there is an increased risk of fragility fractures particularly of the lower limbs including an increased risk of hip fracture. Lower limb fragility fractures affect up to 35% of patients following SCI…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Bone Strength","Leg Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03307954"},{"n":"NCT01853488","t":"Bone Strength After Spinal Cord Injury","d":"Background: After a traumatic spinal cord injury, a severe bone loss in the paralyzed extremities is observed. This leads to a osteoporosis which is connected to a high fracture risk. Aims: To compare the two measurement methods DEXA and pQCT concerning optimal diagnostics and assessment of fracture risk in subjects with spinal cord injury. Subjects: 250 women and 250 men (age≥18, any AIS-classification) with an acute or chronic spinal cord injury will be recruited for this study. For a…","s":"Completed","tr":["Observational"],"o":["Bone Strength","Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01853488"},{"n":"NCT04403256","t":"Bone-biomarkers of Spinal Cord Injury Patients","d":"Patients with spinal cord injury have a high prevalence of osteoporosis due to chronic skeletal unloading. Recently, various treatment drugs for osteoporosis have been developed. In particular, romosozumab, a sclerostin inhibitor, has been reported to have a high therapeutic effect as an inhibitor of bone resorption while promoting bone formation. However, there are a few research concerning sclerostin of spinal cord injuries patients. Therefore we want to analyze the change of sclerostin as…","s":"Completed","tr":["Observational"],"o":["Bone Strength"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04403256"},{"n":"NCT06161168","t":"Bootle Blast: Understanding the Family Experience","d":"One in 60 children have a physical disability that can impact activities and participation. Occupational and physical therapies can be of great benefit, but are costly and difficult to access. Working with children, parents and clinicians, the investigators developed a mixed reality video game, Bootle Blast, which children can play to develop motor skills. Using a 3D sensor, Bootle Blast tracks movements and manipulation of real-life objects. Since 2017, Bootle Blast has been used in clinics by…","s":"Unknown","tr":["Devices","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06161168","su":"https://scitrials.org/trial/NCT06161168"},{"n":"NCT02298660","t":"Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI","d":"The purpose of this study is to investigate the impact of 200 U intradetrusor injected OnabotulinumtoxinA (Botox®, Allergan, Inc.) (20 sites, trigone sparing) for neurogenic detrusor overactivity (NDO) and its role on reducing autonomic dysreflexia (AD) in those with chronic, traumatic spinal cord injury (SCI). In clinical practice, urinary bladder dysfunctions are commonly associated with episodes of AD. If AD is misdiagnosed or poorly managed, it may result in myocardial infarction, stroke…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Blood Pressure","Mental Health","Quality of Life","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02298660"},{"n":"NCT00711087","t":"Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)","d":"The purpose of this study is to see what the effect of Botox has on bladder function for those who have recently suffered spinal cord injury. We also will study bladder tissue levels of NGF (nerve growth factor) that can tell us how the nerves to the bladder are healing after injury. Consenting male and female cervical and high thoracic (T10 and above) SCI patients will be identified within the first 6-7 weeks after SCI and randomized to two external urethral sphincter injection groups. Each…","s":"Terminated","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00711087"},{"n":"NCT01911377","t":"Botulinum Toxin Type A for Treating Allodynic Pain in SCI and MS","d":"This study will examine the efficacy of Botulinum Toxin Type A (\"Botox\") in treating Allodynic-type neuropathic pain in people with spinal cord injury or multiple sclerosis. Neuropathic pain is pain initiated or caused by injury to or disease of the nervous system, and is common in spinal cord injury patients or people with multiple sclerosis. Allodynia is a type of neuropathic pain caused by something that normally would not cause pain, such as light touch, pressure from clothing, or bed…","s":"Terminated","tr":["Drugs"],"o":["Mental Health","Pain Management","Sensory Function","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01911377"},{"n":"NCT00262496","t":"Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.","d":"The purpose of the study is to determine whether Botulinum-A toxin injected in the bladder muscle will help prevent the frequency and degree of urinary incontinence in Spinal Cord Injured and Multiple Sclerosis patients. The proposed mechanism would be that the Toxin would allow the bladder to hold more urine at a lower pressure as determined by Urodynamics. The research will answer the question whether the dosages 300 units vs 400 units are either equally vs not equally effective in helping…","s":"Withdrawn","tr":["Drugs","Surgical Procedure"],"o":["Bladder Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00262496"},{"n":"NCT01567605","t":"Bowel Care and Cardiovascular Function After Spinal Cord Injury","d":"The main goal of this project is to determine the effects of lidocaine lubricant on cardiovascular function during routine bowel care in individuals with spinal cord injury. Bowel care is a common trigger of blood pressure and heart rate changes after spinal cord injury. In this project, we will be measuring blood pressure and heart rate non-invasively during normal bowel routine (which can be performed in the subject's home or at one of the investigators facilities). The measurements will…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Bowel Function"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01567605"},{"n":"NCT04386174","t":"Brain Activity in People With Chronic Neuropathic Pain and Spinal Cord Injury","d":"The purpose of this research study is to learn more about how patterns of brain activity change during different thinking tasks and how these changes relate to the intensity and unpleasantness of the neuropathic pain that people with SCI experience.","s":"Unknown","tr":[],"o":["Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04386174","su":"https://scitrials.org/trial/NCT04386174"},{"n":"NCT05098587","t":"Brain Activity Patterns in Persons With Spinal Cord Injury and Neuropathic Pain After a Virtual Walking Training Program","d":"The aim of this pilot study is to explore the association of changes in pain perception with changes in brain activity (functional Magnetic Resonance Imaging (fMRI)) and metabolic (Magnetic Resonance Spectroscopy (MRS)) patterns of individuals with SCI and chronic NeP after a Virtual Walk (VW) therapy. The brain activity patterns will be assessed in resting state and under a specific task, before and after a VW training program, done as part of the clinical routine, as well as at a four weeks…","s":"Completed","tr":["Observational"],"o":["Mental Health","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05098587"},{"n":"NCT02469675","t":"Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS","d":"Most neurological injuries such as spinal cord injuries (SCI) and amyotrophic lateral sclerosis (ALS) spare a portion of nerve circuitry. Strengthening spared nerve circuits may be an important method to improve functional recovery. In this study, the investigators aim to use non-invasive magnetic and electrical stimulation to strengthen motor circuits between the brain and hands. Magnetic stimulation will be used over the motor cortex (scalp). Two methods of electrical stimulation will be…","s":"Completed","tr":["Electrical Stimulation","Safety","Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Hand Movement","Motor Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02469675"},{"n":"NCT05665998","t":"Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation","d":"Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function. Decoding of motor intentions can be achieved through implantable electrocorticography (ECoG) devices. In this study, the investigators will use an investigational system using ECoG signal recording over the motor cortex to drive muscle…","s":"Recruiting","tr":["Brain Stimulation","Epidural Stimulation"],"o":["Arm Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05665998","su":"https://scitrials.org/trial/NCT05665998"},{"n":"NCT06243952","t":"Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation","d":"The purpose of this clinical study is to evaluate the preliminary safety and effectiveness of using a cortical recording device (ECoG) combined with lumbar targeted epidural electrical stimulation (EES) of the spinal cord to restore voluntary motor functions of lower limbs in participants with chronic spinal cord injury suffering from mobility impairment. The goal is to establish a direct bridge between the motor intention of the participant and the the spinal cord below the lesion, which…","s":"Active, not recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06243952","su":"https://scitrials.org/trial/NCT06243952"},{"n":"NCT01208584","t":"Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions","d":"The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal column), acute and chronic complete spinal cord lesions. The findings of this study may provide a basis to better understand the pathomechanisms underlying the dynamic neurofunctional changes following a spinal cord lesions in man. This understanding is important for…","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01208584"},{"n":"NCT02564419","t":"Brain Machine Interface (BMI) in Subjects Living With Quadriplegia","d":"In this study, investigators will show proof-of-concept that brain signals can be used in real-time, closed-loop mode to trigger stimulation for hand function. Subjects will undergo surgery to implant a unilateral subdural strip electrode (Resume II, Model 3587A) over the motor cortex. These electrodes implanted in the brain will enable bioelectrical data recording (sensing) from the brain to the implanted Activa PC+S. The cortical sensing data will be 1. either processed in the Activa PC+S; or…","s":"Completed","tr":["Brain Machine Interface (BMI)","Devices","Surgical Procedure"],"o":["Hand Movement","Motor Function","Quality of Life","Sensory Function","Spasticity"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02564419"},{"n":"NCT06813287","t":"Brain Monitoring, tDCS and Robotic Training in SCI","d":"To explore the neurophysiological and electroencephalography (EEG) changes that one single session of tDCS and robotics has in the SCI population (Study 1); and to investigate upper limb motor recovery in chronic tetraplegia SCI patients, comparing two rehabilitation strategies: real or sham tDCS combined with upper-limb robotic therapy (Study 2), as well as to characterize the neurophysiological (TMS) and brain signaling (EEG) profile of patients and specific muscles that respond to the…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06813287"},{"n":"NCT04727866","t":"Brain Plus Spinal Stimulation for Cervical SCI","d":"The goal of this project is to strengthen residual corticospinal tract (CST) connections after partial injury using combined motor cortex and spinal cord stimulation to improve arm and hand function after spinal cord injury (SCI). To do this, the investigators will test the combination of transcranial magnetic stimulation (TMS) with transcutaneous spinal direct current stimulation (tsDCS) in individuals with chronic cervical SCI.","s":"Completed","tr":["Brain Stimulation","Electrical Stimulation","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04727866"},{"n":"NCT04632290","t":"Brain-controlled Spinal Cord Stimulation in Patients With Spinal Cord Injury","d":"In a current first-in-human study, called Stimulation Movement Overground (STIMO, NCT02936453), Epidural Electrical Stimulation (EES) of the spinal cord is applied to enable individuals with chronic severe spinal cord injury (SCI) to complete intensive locomotor neurorehabilitation training. In this clinical feasibility study, it was demonstrated that EES results in an immediate enhancement of walking function, and that when applied repeatedly as part of a neurorehabilitation program, EES can…","s":"Active, not recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04632290","su":"https://scitrials.org/trial/NCT04632290"},{"n":"NCT06406855","t":"Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)","d":"The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord injury (SCI).","s":"Recruiting","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06406855","su":"https://scitrials.org/trial/NCT06406855"},{"n":"NCT02678494","t":"Brain-Train Home Based Pain Treatment","d":"A study examining the effectiveness of neurofeedback therapy for the treatment of Central Neuropathic Pain (CNP), in patients with a Spinal Cord Injury, using a small user-friendly device which can be operated by patients at home.","s":"Completed","tr":["Devices"],"o":["Pain Management"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02678494"},{"n":"NCT04440709","t":"Brain/Neural Hand Exoskeleton Control for Restoration of Bimanual Tasks","d":"This study investigates whether spinal cord injury and stroke survivors (n=10) are able to operate a brain/neural hand exoskeleton (B/NHE) based on electroencephalography (EEG) and electrooculography (EOG) for restoration of bimanual activities of daily living (ADLs). To assess bimanual ADLs, the Berlin Bimanual Task Assessment (BEBITA) will be applied. Improvements in BEBITA will be evaluated with and without B/NHE use.","s":"Unknown","tr":["Exoskeleton"],"o":["Hand Movement"],"st":[],"co":["Germany"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT04440709","su":"https://scitrials.org/trial/NCT04440709"},{"n":"NCT00912041","t":"BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia","d":"The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["California","Georgia","Massachusetts","Rhode Island","Texas"],"co":["United States"],"lc":6,"rlc":6,"cu":"https://clinicaltrials.gov/study/NCT00912041","su":"https://scitrials.org/trial/NCT00912041"},{"n":"NCT02443558","t":"Brainwave Control of a Wearable Robotic Arm for Rehabilitation and Neurophysiological Study in Cervical Spine Injury","d":"CSI:Brainwave is a multidisciplinary neurophysiological project, developed by the Lab of Medical Physics, School of Medicine, Aristotle University of Thessaloniki and supported by two Neurosurgical Departments. The project officially commenced on April 2014 and the first year was awarded the 2013 Mario Boni Research Grant by the Cervical Spine Research Society-European Section (CSRS-ES). The website for the project can be accessed at http://medphys.med.auth.gr/content/csi-brainwave. The…","s":"Completed","tr":["Brain Machine Interface (BMI)","Devices","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02443558"},{"n":"NCT07659743","t":"BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)","d":"The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management of neuropathic pain in patients after spinal cord injury (SCI).","s":"Not yet recruiting","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Breathing Function","Pain Management"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07659743"},{"n":"NCT03554733","t":"Bridge Reinvention","d":"The goal of this randomized controlled trial is to determine the efficacy of a treatment to improve resilience to stress for individuals with SCI who are transitioning from inpatient rehabilitation to home. The overarching hypothesis is that individuals who participate in an intervention that presents positive psychotherapy topics in an interactive, structured, cognitive-behaviorally-based group intervention that stresses restructuring maladaptive thought processes and provides experiential…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03554733"},{"n":"NCT05233111","t":"Brief Prolonged Exposure Therapy Versus Clinical Standard to Reduce Posttraumatic Stress Post Spinal Cord Injury","d":"This study will examine the use brief prolonged exposure (Brief PE) therapy compared to standard clinical care to reduce posttraumatic distress among people who have had a spinal cord injury and are receiving rehabilitation in an inpatient setting.","s":"Enrolling by invitation","tr":[],"o":["Mental Health"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05233111","su":"https://scitrials.org/trial/NCT05233111"},{"n":"NCT05639946","t":"Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","d":"Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to pharmacological intervention. Preliminary data suggest brivaracetam is a mechanism-based pharmacological intervention for neuropathic pain in SCI. Based on this and other reports in the literature, SCI-related neuropathic pain is hypothesized to occur largely because of upregulation of synaptic vesicle protein 2A (SV2A) within the substantia gelatinosa of the injured spinal cord. Furthermore…","s":"Completed","tr":["Drugs"],"o":["Mental Health","Motor Function","Pain Management","Plasticity"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05639946"},{"n":"NCT04379011","t":"Brivaracetam to Reduce Neuropathic Pain in Chronic Spinal Cord Injury","d":"Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to all pharmacological intervention. Preliminary data suggest brivarecetum is a mechanism-based pharmacological intervention for neuropathic pain in SCI. This randomized, placebo-controlled pilot clinical trial will assess feasibility of a 3-month treatment course with brivarecetum.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["Colorado","Minnesota"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04379011"},{"n":"NCT03874988","t":"Building an Evidence Base for Weight Loss Strategies Among Those With Chronic SCI-The GLB-SCI+","d":"This study's overarching aim is to follow a systematic approach that incorporates community-based participatory research (CBPR) to develop a multi-component weight loss intervention that may yield significant effects for a chronic SCI sample. The approach is to obtain data on the 3 unique strategies (prepackaged/portion-controlled meals; enhanced self-monitoring; the GLB-SCI) to inform design of an empirically supported and consumer-validated multicomponent intervention program, that combines…","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03874988"},{"n":"NCT03930056","t":"C-Brace II Spinal Cord Injury","d":"A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs. traditional care knee-ankle-foot-orthosis (KAFO) models following discharge from inpatient rehabilitation.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03930056","su":"https://scitrials.org/trial/NCT03930056"},{"n":"NCT03567902","t":"C-MAC Videolaryngoscope Intubation and Cervical Spine Motion","d":"The aim of the study is to compare the effect of the C-MAC videolaryngoscope intubation technique vs. the conventional direct laryngoscope intubation technique on the cervical spine motion during intubation in patients with the simulated cervical immobilization.","s":"Unknown","tr":["Devices"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03567902"},{"n":"NCT05805683","t":"Calcitonin Therapy on Incidence and Severity of Neuropathic Pain After Spinal Cord Injury","d":"This prospective randomized double blinded study will be conducted to evaluate the effect of early pharmacologic intervention with calcitonin on the incidence or the severity of neuropathic pain after spinal cord injury","s":"Recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["Egypt"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05805683","su":"https://scitrials.org/trial/NCT05805683"},{"n":"NCT05467215","t":"Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?","d":"This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic, severe spinal cord injury (SCI).","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Regeneration"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05467215","su":"https://scitrials.org/trial/NCT05467215"},{"n":"NCT03023696","t":"Can Prophylactic Foraminotomy Prevent C5 Palsy","d":"C5 palsy (C5P) is a well-known, although rare complication of cervical spine decompression surgery. In severe forms, C5P causes debilitating upper extremity weakness involving the deltoids and/or biceps brachii muscles, ultimately diminishing these patients' quality of life. Furthermore, about half of patients with C5P present with sensory deficits and/or intractable pain in addition to the muscle weakness. Prophylactic bilateral foraminotomy at the C5 level during cervical decompression…","s":"Recruiting","tr":["Surgical Procedure"],"o":["Arm Movement","Pain Management","Quality of Life"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03023696"},{"n":"NCT02043106","t":"Can Vibration Stimulation of the Foot Sole Activate Leg Muscles?","d":"Participants will be asked to complete three different tests (standing, stepping and assisted walking) and will experience three different experimental conditions during each test. The three conditions are types of vibratory plantar cutaneous stimulation, which include no vibratory stimulation, submaximal vibratory stimulation and supramaximal vibratory stimulation. In the first condition, participants will experience no stimulation applied to any part of the body. In the second condition, a…","s":"Completed","tr":[],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02043106"},{"n":"NCT06700304","t":"CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","d":"The CAN-PRIME Study is to test the safety and functionality of Neuralink's N1 Implant and R1 Robot in people who have difficulty moving their arms and legs (tetraparesis or tetraplegia). The N1 Implant is a small, wireless device placed in the skull. It connects to tiny threads inserted into the brain by the R1 Robot, which is a machine designed to carefully place these threads. This study will help researchers learn how well the implant and robot work and if they are safe for use.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06700304","su":"https://scitrials.org/trial/NCT06700304"},{"n":"NCT03911492","t":"Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study","d":"This multicenter study will enroll 100 patients with acute traumatic cervical and thoracic SCI who have a lumbar intrathecal catheter inserted within 24 hours of their injury. The lumbar intrathecal catheter will be inserted pre-operatively for the measurement of ITP and the collection of cerebrospinal fluid (CSF) samples. SCPP will be calculated as the difference between MAP and the ITP. There are two important distinct yet related objectives in this prospective interventional study. 1…","s":"Unknown","tr":["Safety"],"o":[],"st":["California","Nebraska","New Mexico","Pennsylvania"],"co":["Canada","United States"],"lc":8,"rlc":8,"cu":"https://clinicaltrials.gov/study/NCT03911492","su":"https://scitrials.org/trial/NCT03911492"},{"n":"NCT04057456","t":"Cannabinoids and an Anti-inflammatory Diet for the Treatment of Neuropathic Pain After Spinal Cord Injury","d":"Neuropathic pain is a common complication following spinal cord injury (SCI) that significantly decreases quality of life. Treatment options are limited, and current treatments can have significant side effects. Those with SCI have identified a need for additional treatment options, particularly those that are not medications. Nabilone and an anti-inflammatory diet are two treatments that may provide pain relief while being better tolerated. This study will evaluate the benefits of these…","s":"Completed","tr":["Drugs","Nutrition"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04057456"},{"n":"NCT02441660","t":"Capsaicin 8% Patch for Spinal Cord Injury Neuropathic Pain","d":"A prospective case control study to determine the effectiveness and longevity of 8% capsaicin patch(es) in treating neuropathic pain in persons with spinal cord injury. The investigators will study spinal cord injury patients at South Texas Veterans Health Care Systems Spinal Cord Injury inpatient unit and outpatient clinics.","s":"Completed","tr":["Drugs"],"o":["Pain Management","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02441660"},{"n":"NCT00786435","t":"Carbohydrate Study, Chronic SCI","d":"As people with spinal cord injuries (SCI) get older they become more likely to develop health problems, just like everyone else. However, SCI increases the risk of certain problems. This research project will focus on the control of blood sugar after SCI. Sugar in the blood is the important source of energy for the body. Too much sugar in the blood is known as hyperglycemia and not enough sugar in the blood is known as hypoglycemia. Under healthy conditions, the amount of sugar in the blood is…","s":"Completed","tr":["Observational"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00786435"},{"n":"NCT06293157","t":"Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease","d":"Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located. Due to the complexity of the clinical problem, metastatic spine disease remains of interest to many medical specialties: neurosurgery, orthopedics, clinical oncology, radiotherapy and rehabilitation. With the development of modern diagnostic methods and wider access to them, the…","s":"Recruiting","tr":["Rehabilitation","Surgical Procedure"],"o":["Pain Management"],"st":[],"co":["Poland"],"lc":5,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06293157"},{"n":"NCT00013325","t":"Cardiac Disease and the Electrocardiogram in SCI Patients","d":"The purpose of this three-year study is to determine the prevalence and incidence of the different types of cardiac disease and ECG abnormalities in SCI patients. Study goals are: (i) delineation of the specific types of heart disease that occur in the SCI population as manifested both pre-clinically and clinically and (ii) demonstration of their association with ECG findings. This will enable validation of scores and algorithms using the inexpensive and widely available ECG for the prevention…","s":"Completed","tr":["Observational","Rehabilitation"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00013325"},{"n":"NCT07456722","t":"Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia","d":"This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI/D (above Th6) who have AD and 24 individuals with low-level SCI/D (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and…","s":"Recruiting","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07456722","su":"https://scitrials.org/trial/NCT07456722"},{"n":"NCT01204632","t":"Cardiometabolic Risk, Obesity and Cardiovascular Disease in People With Spinal Cord Injury","d":"The purpose of this study is to develop and field-test new tools for diagnosis and hazard assessment of cardiometabolic risk (CMR) in people with chronic spinal cord injury (SCI) and to advance the evidence base with much needed information on CMR and cardiovascular disease (CVD) burden in people with SCI. These data can be used to develop screening guidelines for early identification and prevention of CMR in SCI, as well as targeted approaches to primary disease management.","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01204632"},{"n":"NCT06027502","t":"Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept","d":"As compared to the general population, those living with a spinal cord injury (SCI) are at a greater risk of cardiovascular (CV) diseases.The investigators know that regular exercise can help lessen the risk of CV diseases. However, those with higher level SCI have a limited ability to exercise due to their loss of function. Heat therapy has been shown to promote significant health benefits in populations with health challenges and has demonstrated a mild exercise like response. The…","s":"Unknown","tr":["Rehabilitation"],"o":["Temperature Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06027502","su":"https://scitrials.org/trial/NCT06027502"},{"n":"NCT06379711","t":"Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury","d":"The aim of this study is to examine the mechanisms of transcutaneous spinal cord stimulation (tSCS) for improving cardiovascular and pulmonary function in individuals with chronic motor-complete spinal cord injury (SCI) by measuring vascular related endothelial biomarkers, plasma catecholamines, and respiratory parameters.","s":"Not yet recruiting","tr":["Transcutaneous Stimulation"],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06379711","su":"https://scitrials.org/trial/NCT06379711"},{"n":"NCT06259227","t":"Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury","d":"The goal of this exploratory randomized controlled trial is to assess the effect of a personalized training intervention during primary rehabilitation of 6 weeks on cardiorespiratory fitness in individuals with subacute (\\<6 months) spinal cord injury during primary rehabilitation and during follow-up. Secondary outcomes include the effect on gait assessments, pulmonary function, neurological status, muscle force, cardiometabolic risk factors, quality of life, functional independence and…","s":"Terminated","tr":["Rehabilitation"],"o":["Bladder Function","Blood Pressure","Bowel Function","Breathing Function","Hand Movement","Motor Function","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06259227"},{"n":"NCT07725952","t":"Cardiovascular Autonomic Function After Resistance Training","d":"The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI). The primary objectives are to determine whether upper-limb resistance training improves heart rate variability (HRV) and baroreflex sensitivity (BRS), and whether it improves blood pressure responses during postural change, upper-limb strength, symptoms related to orthostatic hypotension, and…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Blood Pressure","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07725952"},{"n":"NCT00857194","t":"Cardiovascular Disease Study","d":"Coronary heart disease (CHD) is a leading cause of death in the spinal cord injured (SCI) population, occurring at younger ages than in the able-bodied population. Conventional risk factors for CHD include high concentrations of low-density lipoprotein (LDL), low concentrations of high-density lipoprotein (HDL), diabetes mellitus (DM), smoking history, and family history. Other factors that may influence progression of CHD include C-reactive protein (an inflammatory marker), and fibrinogen (a…","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00857194"},{"n":"NCT04378218","t":"Cardiovascular Effects of High Intensity Interval Training in Individuals With Paraplegia","d":"The study seeks to determine whether high intensity interval training has an effect on cardiovascular parameters in wheelchair users with paraplegia.","s":"Completed","tr":[],"o":["Blood Pressure","Bone Strength"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04378218"},{"n":"NCT06841198","t":"Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury","d":"The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure. The main questions are: How does stimulation affect blood pressure over the year? What is the level of cardiovascular activation throughout the year? The study will start during the inpatient stay at the Kessler Institute for Rehabilitation and continue…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06841198","su":"https://scitrials.org/trial/NCT06841198"},{"n":"NCT01718977","t":"Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)","d":"This study aims to determine whether body weight-supported treadmill training (BWSTT) has beneficial effects, over and above arm-cycle ergometry training (ACET) on indicators of cardiovascular disease (CVD) risk in individuals with severe spinal cord injury (SCI). After SCI, the primary cause of illness and death is CVD. Currently, preventative measures focus around increasing physical activity- especially through the use of ACET. However, ACET's capacity to improve cardiovascular health is…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Quality of Life"],"st":[],"co":["Canada"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01718977"},{"n":"NCT03352505","t":"Cardiovascular Risk Markers in Spinal Cord Injured Subjects of the Wheelchair Dancer Study","d":"The present study will analyze if exercise is able to elicit the well-known anti-atherogenic effects in patients with SCI. This will be evaluated by measuring vascular parameters such as endothelial and inflammatory blood markers, echocardiography of the heart and peripheral vessels, as well as blood pressure and arterial stiffness, in subjects performing either wheelchair dancing, wheelchair marathon or no sports. Further, it will be investigated, whether there is an association between…","s":"Completed","tr":["Observational","Transcranial Magnetic Stimulation (TMS)"],"o":["Blood Pressure","Mental Health","Plasticity"],"st":[],"co":["Austria"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03352505"},{"n":"NCT02122991","t":"Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury","d":"Increased life expectancy in individuals with spinal cord injury (SCI) present clinicians with the challenge of managing the secondary complications of SCI with the chronic diseases common in an aging population. Cardiovascular disease, cerebral vascular disease, and cognitive dysfunction are among the primary challenges facing clinicians in the treatment of an aging population. Cognitive dysfunction has been reported in upwards of 60% of the SCI population, which have been primarily attributed…","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02122991"},{"n":"NCT05295108","t":"Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury","d":"This study will use a randomized controlled design with an active attention control group to evaluate an intervention intended to reduce social isolation and loneliness in persons with SCI/D. The intervention, Caring Connections, is a peer-based intervention which is important because peers with SCI/D play an important role in improving quality of life, mental health, and social health in persons with SCI/D.","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05295108"},{"n":"NCT02083601","t":"Caring for Caregivers: Supporting Caregivers of Youth With Spinal Cord Injury","d":"The current study will implement and evaluate a multi-component, psychoeducational intervention for caregivers of children with spinal cord injury (SCI) ages 7-12. Two hypotheses will be tested. First, caregivers who participate in the intervention group will demonstrate better outcomes than caregivers in the control group. Second, children with SCI whose caregivers participate in the intervention group will demonstrate better outcomes than children with SCI whose caregivers participate in the…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02083601"},{"n":"NCT03815721","t":"Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity","d":"Spinal cord injury is a devastating condition, causing substantial impairment of vital body functions caudal to the lesion. A major cause of disability stems from spasticity, a common secondary sequelae. Its various clinical manifestations include spasms, clonus, and resistance to passive movements, and often present a major hindrance in rehabilitation, further deteriorate residual motor performance, and negatively impact independence and quality of life. Despite its high prevalence, successful…","s":"Terminated","tr":["Electrical Stimulation","Epidural Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03815721"},{"n":"NCT06840899","t":"CBD for Lower Urinary Tract Dysfunction in Spinal Cord Injury","d":"The goal of this feasibility study is to learn whether Cannabidiol (CBD) can improve urinary incontinence and other symptoms in people with recent spinal cord injury (SCI). Participants will take Epidiolex (purified CBD) for 90 days","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":["Wisconsin"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06840899","su":"https://scitrials.org/trial/NCT06840899"},{"n":"NCT06410001","t":"CE-STAND: Cervical Epidural STimulation After Neurologic Damage","d":"CE-STAND aims to address three areas under-represented in research: chronic, cervical, and autonomic dysfunction. It is both significant and highly impactful, as treating autonomic dysfunction could substantially improve function and quality of life (QoL) in chronic cervical SCI patients.","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Blood Pressure"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06410001","su":"https://scitrials.org/trial/NCT06410001"},{"n":"NCT05054803","t":"Cell Therapy for Chronic Traumatic Cervical Incomplete Spinal Cord Injury","d":"This is a double-blind, randomized, placebo-controlled, multicenter clinical trial in which 18 patients affected with chronic traumatic incomplete cervical spinal cord injury will be randomized to either the active treatment (2 doses of intrathecal WJ-MSC 3 months apart) or to placebo (2 intrathecal infusions, 3 months apart). Thereafter, patients will be followed-up for 12 months for safety and efficacy assessment.","s":"Completed","tr":["Drugs","Stem Cells"],"o":["Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05054803"},{"n":"NCT00816803","t":"Cell Transplant in Spinal Cord Injury Patients","d":"This study is designed to assess the safety of autologous bone marrow derived cell transplant in chronic spinal cord injury patients. The hypothesis is that the availability of bone marrow derived mesenchymal stem cells at the sites of injury promote neuronal regeneration.","s":"Completed","tr":["Rehabilitation","Stem Cells"],"o":["Quality of Life","Regeneration"],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00816803"},{"n":"NCT00135278","t":"Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)","d":"The overall purpose of this pilot study is to evaluate CSF drainage as a potential neuroprotective strategy after acute spinal cord injury (SCI).","s":"Completed","tr":["Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00135278"},{"n":"NCT02495545","t":"Cerebrospinal Fluid Drainage (CSFD) in Acute Spinal Cord Injury","d":"The purpose of this Phase IIB randomized controlled trial is to evaluate the safety and efficacy of CSFD and to provide a preliminary clinical efficacy evaluation of the combination of CSFD and elevation of mean arterial pressure (MAP) in patients with acute spinal cord injury (SCI). The objectives of the trial are to evaluate (i) efficacy of reducing intrathecal pressure (ITP) by CSFD in patients with acute SCI; (ii) preliminary efficacy of combination of CSFD and elevation of MAP compared to…","s":"Completed","tr":[],"o":["Arm Movement","Leg Movement","Motor Function","Pain Management","Quality of Life"],"st":["Alabama","Arizona"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02495545"},{"n":"NCT04623593","t":"Cervical Arthroplasty Cost Effectiveness Study (CACES)","d":"To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multilevel symptomatic CDDD is anterior cervical discectomy with fusion (ACDF). However, new complaints of radiculopathy and/or myelopathy commonly develop at adjacent levels, also known as clinical adjacent segment pathology (CASP). It remains unknown to what extent kinematics…","s":"Recruiting","tr":["Devices","Surgical Procedure"],"o":["Mental Health","Pain Management"],"st":[],"co":["Netherlands"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04623593"},{"n":"NCT07539025","t":"Cervical Spinal Cord Associative Plasticity","d":"Associative plasticity has been used to promote functional recovery from conditions affecting movement. Prior work from the Carmel laboratory has shown that paired associative stimulation protocols timed to converge in the cervical spinal cord induce significantly larger upper limb motor responses than if timed to converge in the motor cortex. The goal of this prospective experimental study in typically developing adults is to test the effects of pairing sub-threshold hand motor cortical and…","s":"Recruiting","tr":["Devices"],"o":["Arm Movement","Hand Movement","Plasticity"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07539025"},{"n":"NCT02053883","t":"Cethrin in Acute Cervical Spinal Cord Injury","d":"This is a multicenter, randomized, double-blind, placebo-controlled Phase IIb/III study designed to evaluate the efficacy and safety of Cethrin as a treatment for acute cervical spinal cord injury. During the trial, high and low doses of Cethrin will be compared with placebo.","s":"Withdrawn","tr":["Drugs"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02053883"},{"n":"NCT05530798","t":"CEUS For Intraoperative Spinal Cord Injury","d":"Spinal cord injury following posterior decompression in patients suffering from chronic, cervicothoracic spinal cord compression is a known complication with multiple etiologies. Currently, intraoperative neuromonitoring (IONM) remains the gold standard for predicting and preventing post-operative deficits from these procedures. However, there is a paucity in the field of spine surgery for further, non-invasive biomarkers that can help detect and prognosticate the degree of spinal cord injury…","s":"Completed","tr":["Devices","Surgical Procedure"],"o":[],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05530798"},{"n":"NCT05559255","t":"Changes in Pain, Spasticity, and Quality of Life After Use of Counterstrain Treatment in Individuals With SCI","d":"Individuals with spinal cord injury (SCI) often suffer from pain and spasticity. Traditional treatments for both of these conditions have been medications. However, it has been suggested that the counterstrain osteopathic manual manipulation treatment can decrease pain and possibly spasticity. The aim of this study is to investigate the effects of counterstrain osteopathic manual manipulation treatment on pain and spasticity in individuals with SCI.","s":"Completed","tr":[],"o":["Pain Management","Quality of Life","Spasticity"],"st":["Mississippi"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05559255"},{"n":"NCT00228085","t":"Changes of Parameters of Transcranial Magnetic Stimulation in Patients With Spinal Cord Injury","d":"CNS reorganization is evidenced in patients with CNS lesion, no exception to the patients with spinal cord injury. The paraplegics have to increase their loading of upper extremities to compesate the lost function of lower extremities. We hypothesize that CNS reorganization can happen in the chronic paraplegics. We try to compare the changes of parameters of transcranial magnetic stimulation in these patients with the normal population cross-sectionally.","s":"Unknown","tr":["Transcranial Magnetic Stimulation (TMS)"],"o":["Plasticity"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00228085","su":"https://scitrials.org/trial/NCT00228085"},{"n":"NCT06140355","t":"cHAnging the Perceived Pain INtensity in divErSe Populations With Spinal Cord Injury","d":"Chronic neuropathic pain affects 69% of adults with spinal cord injury (SCI). Current treatment options are limited (primarily pain medications) with insufficient benefits and significant risks for addiction and adverse effects. Of the available mind and body approaches, Qigong is the most accessible for adults with SCI with evidence for effectiveness in reducing pain, but there is insufficient evidence to make recommendations for adults with SCI. Thus, the feasibility of Qigong in SCI needs to…","s":"Recruiting","tr":[],"o":["Pain Management"],"st":["Florida","Minnesota","Texas"],"co":["United States"],"lc":3,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06140355","su":"https://scitrials.org/trial/NCT06140355"},{"n":"NCT03089749","t":"Characterization of Human Autoantibody Titers After Central Nervous System Insult","d":"The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.","s":"Terminated","tr":["Observational"],"o":[],"st":["Utah"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03089749"},{"n":"NCT01470950","t":"Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy","d":"Atrogin-1 and muscle RING finger-1 are skeletal muscle specific genes, with ubiquitin ligase activities, that are upregulated during muscle atrophy in mice. The Akt/GSK3 and Akt/mTOR pathways are involved in muscle hypertrophy in mice. Recent studies by the investigators team and others have demonstrated the implication of these signalling pathways in the control of muscle mass in humans. However no study has yet investigated the involvement of these systems in the early stages of spinal cord…","s":"Unknown","tr":["Functional Electrical Stimulation (FES)","Surgical Procedure"],"o":["Motor Function","Spasticity"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01470950","su":"https://scitrials.org/trial/NCT01470950"},{"n":"NCT04758377","t":"Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI","d":"The study is designed to determine whether hemorrhage within the injured spinal cord is influenced by mean arterial pressure (MAP) augmentation with vasopressors and by venous thromboembolism (VTE) prophylaxis with anticoagulants in the first two weeks following a traumatic spinal cord injury (tSCI).","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04758377","su":"https://scitrials.org/trial/NCT04758377"},{"n":"NCT01084512","t":"Chest Wall Kinematics and Respiratory Muscle Action During Supine Breathing in Individuals With and Without Spinal Cord Injury","d":"Objective: To investigate the movement strategy of breathing based on three-compartment model measured by optoelectronic plethysmography (OEP) and electromyography (EMG ) among individuals with and without spinal cord injury in supine posture during deep inspiration. Design: cross sectional repeated-measure with age matched control group. Setting: Motion Analysis Laboratory Participants: Seven tetraplegic and five paraplegic subjects and twelve age matched healthy controls were recruited…","s":"Completed","tr":["Observational"],"o":["Breathing Function","Trunk Control"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01084512"},{"n":"NCT03472599","t":"Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia","d":"Bladder spasms after spinal cord injury (SCI) can result in incontinence, urinary tract infections, kidney damage, trigger dangerous increases in blood pressure and decrease independence and quality of life. The investigators' long-term goal is to develop and provide a \"bladder pacemaker\" able to restore bladder continence for Veterans with SCI. Electrical stimulation of sensory nerves can stop bladder spasms during a doctor visit. However, this approach has not been tested during long term…","s":"Completed","tr":["Electrical Stimulation"],"o":["Bladder Function","Blood Pressure","Quality of Life"],"st":["New York","Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03472599"},{"n":"NCT01012635","t":"Chronic Pain and Brain Activity in Spinal Cord Injury","d":"This study compares five different procedures to see how they affect pain and brain activity. The procedures include neurofeedback, self-hypnosis training, meditation, and two different levels of transcranial direct current stimulation (tDCS). Subjects will be compensated for their time.","s":"Completed","tr":["Observational","Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01012635"},{"n":"NCT00006428","t":"Chronic Pain in Spinal Cord Injury","d":"This trial tests the effectiveness of the drug amitriptyline vs placebo to relieve chronic pain in adults that have had a spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00006428"},{"n":"NCT04755699","t":"Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis","d":"This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves functional arm/hand movements in individuals with paralysis or paresis due to a spinal cord injury or stroke and improves functional arm/hand or leg/foot movements in individuals with paralysis or paresis due to other brain or nerve injuries. In this study, eligible…","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04755699","su":"https://scitrials.org/trial/NCT04755699"},{"n":"NCT05084170","t":"Cingulotomy for Refractory Neuropathic Pain Following Spinal Cord Injury (CRNP-SCI)","d":"Neuropathic pain is very common following a spinal cord injury, estimated to affect 43% of patients after 6 months. A proportion of these patients do not respond to treatment and there remains an unmet need to treat people with refractory spinal injury related neuropathic pain. While neuropathic pain medications, baclofen pumps and spinal cord stimulation work for some patients, a significant number are refractory to these therapies. Chronic pain can contribute to loss of functional ability…","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05084170","su":"https://scitrials.org/trial/NCT05084170"},{"n":"NCT04263272","t":"Circuit Training Program for Persons With Spinal Cord Injury","d":"This initiative represents development and pilot testing of a circuit training exercise program for persons with spinal cord injury (SCI) to be implemented within a rehabilitation centre. The program will integrate members of the community who are \\> 18 months post-injury with those currently participating in SCI rehabilitation as inpatient.","s":"Unknown","tr":["Rehabilitation"],"o":["Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04263272","su":"https://scitrials.org/trial/NCT04263272"},{"n":"NCT04673240","t":"CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY","d":"Spasticity has been defined as a disorder of the sensorimotor system characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the stretch reflex. The treatment goal of spasticity is Medical treatment generally combines physiotherapy with medications, depending on spasticity distribution. Systemic treatments such as oral or intrathecal baclofen are generally considered in case of generalized…","s":"Unknown","tr":[],"o":["Spasticity"],"st":[],"co":["Italy"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04673240","su":"https://scitrials.org/trial/NCT04673240"},{"n":"NCT00011609","t":"Clinical Evaluation of a Wheelchair Mounted Robotic Arm","d":"The primary purpose of this project, is to evaluate the effect of a wheelchair mounted robotic arm (WMRA) to improve the functional independence of veterans with SCI. The study will determine if the ability to perform marker tasks within the following four categories is improved after the 4 week training period using the robotic arm: 1\\. activities of daily living, 2. vocational tasks, 3. advanced tasks, and subject-specific tasks.","s":"Completed","tr":["Devices"],"o":["Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00011609"},{"n":"NCT01935687","t":"Clinical Evaluation of Instrumented Wheel as Biomedical Device Quantifying the Displacement Efficiency","d":"The purpose of this study is to validate an instrumented wheel such as a new biomedical device. The physicians will compare this instrumented wheel with another instrumentation \"Ergometer roller\", each patient will try the both instrumentations, physical and physiological parameters will be measured. The increase rate of radial power during the cardiac stress test may be more important when the physicians use the instrumented wheel.","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01935687"},{"n":"NCT05643313","t":"Clinical Investigation on Feasibility and Usability of the ABLE Exoskeleton Device for Individuals With Spinal Cord Injury to Perform Skills for Home and Community Environments","d":"The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians. Exoskeletal technology has the potential to help people with impaired leg function to regain ambulation and thus improve their independence. This technology is not completely new, but due to their high access price (\\~120k€/unit), high size and weight (\\~25 kg), and need for trained physiotherapist…","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Mental Health","Quality of Life","Walking Function"],"st":[],"co":["Germany","Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05643313"},{"n":"NCT04876794","t":"Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting","d":"The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians. Exoskeletal technology has the potential to help people with impaired leg function to regain ambulation and thus improve their independence. This technology is not completely new, but due to their high access price (\\~120k€/unit), high size and weight (\\~25 kg), and need for trained physiotherapist…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Mental Health","Quality of Life","Walking Function"],"st":[],"co":["Germany","Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04876794"},{"n":"NCT05590065","t":"Clinical Investigation on the Impact on Safety, Feasibility and Usability of the Design Changes Performed on ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting","d":"The loss of the ability to walk and the associated restriction of mobility presents a major challenge to people with spinal cord injury in an everyday environment designed for pedestrians. Exoskeletal technology has the potential to help people with impaired leg function to regain ambulation and thus improve their independence. This technology is not completely new, but due to their high access price (\\~120k€/unit), high size and weight (\\~25 kg), and need for trained physiotherapist…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation","Safety"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05590065"},{"n":"NCT07550699","t":"Clinical Investigation to Validate the Safety and Performance of Integrating Functional Electrical Stimulation Into the ABLE Exoskeleton","d":"The primary objective of this study is to validate the safety and clinical performance of the ABLE Exoskeleton with integrated Functional Electrical Stimulation (ABLE FES) in individuals with neurological conditions that impair gait, including spinal cord injury, acquired brain injury, and multiple sclerosis. The secondary objective is to collect preliminary data on the potential clinical and psychosocial benefits of combining robotic gait assistance with electrical stimulation.","s":"Completed","tr":["Exoskeleton","Functional Electrical Stimulation (FES)"],"o":[],"st":[],"co":["Austria"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07550699","su":"https://scitrials.org/trial/NCT07550699"},{"n":"NCT07745712","t":"Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting","d":"The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program in a clinical setting. The secondary objective of the study focuses on obtaining preliminary data on the potential clinical and psychosocial benefits of the product.","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07745712"},{"n":"NCT04952246","t":"Clinical Isolation Syndrome of Spinal Cord and Multiple Sclerosis","d":"The purpose of this study was to investigate the factors that influence the progression of patients with clinically isolated spinal cord syndrome to multiple sclerosis.","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04952246"},{"n":"NCT01435798","t":"Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial","d":"This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of three doses of chronic oral (PO) dextromethorphan compared to placebo in central neuropathic pain following spinal cord injury. Subjects' maximally tolerated doses (MTD) were first determined to establish individual dose-analgesic response relationships in a run-in period; following a washout period, subjects were then randomized to receive…","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01435798"},{"n":"NCT02218203","t":"Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial","d":"This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and intravenous (IV) lidocaine in central neuropathic pain following spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02218203"},{"n":"NCT07407725","t":"Clinical Outcome Assessment for AT & BCI","d":"Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers. Clinicians and researchers currently lack a common framework to objectively quantify how much a given AT or BCI improves real-world function or to compare across tools. This project seeks to address this gap by developing a standardized method to objectively assess or compare the functional benefit of these tools on…","s":"Recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07407725","su":"https://scitrials.org/trial/NCT07407725"},{"n":"NCT01292941","t":"Clinical Study Evaluating Safety of a New Catheter for Urinary Intermittent Catheter in Healthy Volunteers","d":"To evaluate discomfort of a new coating and catheter material compared to SpeediCath (SC)","s":"Withdrawn","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01292941"},{"n":"NCT00629642","t":"Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis","d":"A clinical study to evaluate the efficacy and safety of solifenacin in patients with bladder symptoms due to spinal cord injury or multiple sclerosis","s":"Completed","tr":["Drugs"],"o":["Bladder Function"],"st":[],"co":["Australia","Belgium","Czechia","France","Germany","Hungary","Italy","Netherlands","Russia","Spain","United Kingdom"],"lc":39,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00629642"},{"n":"NCT03643419","t":"Clinical Study of Treatment of Acute Spinal Cord Injury by Near Infrared Light Irradiation","d":"The purpose of this study was to observe the therapeutic effect of near-infrared light irradiation on the treatment of acute spinal cord injury in humans, and whether it can promote the recovery of neurological function. Half of the patients underwent laminectomy and decompression surgery, and the other half of the patients were implanted with irradiated fibers for irradiation after surgery.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03643419","su":"https://scitrials.org/trial/NCT03643419"},{"n":"NCT06725836","t":"Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography","d":"The aim of the study is to identify the specific characteristics of brain network dysfunctions and assess the recovery of their functionality through the recording of resting-state electroencephalography (EEG) during rehabilitation using spinal cord stimulation (SCS). Researchers expect that effective SCS scenarios will result in progressive alterations in the quantitative metrics of resting-state EEG throughout the rehabilitation period. The data obtained may be used to optimize rehabilitation…","s":"Recruiting","tr":["Epidural Stimulation","Observational"],"o":[],"st":[],"co":["Russia"],"lc":3,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06725836","su":"https://scitrials.org/trial/NCT06725836"},{"n":"NCT02341950","t":"Clinical Trial of a Serious Game for Individuals With SCI/D","d":"This study will evaluate the efficacy of a newly developed serious game, SCI HARD, to enhance self-management skills, self-reported health behaviors, and quality of life among adolescents and young adults with spinal cord injury and disease (SCI/D). SCI HARD was designed by the project PI, Dr. Meade, in collaboration with the UM3D (University of Michigan three dimensional) Lab between 2010 and 2013 with funding from a NIDRR (National Institute on Disability and Rehabilitation Research) Field…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02341950"},{"n":"NCT06964256","t":"Clinical Trial of Abdominal Breathing for Urinary Retention After Spinal Cord Injury","d":"Randomized controlled trials were conducted in patients with urinary retention after spinal cord injury. The effects of abdominal breathing training on pelvic floor muscle tone, muscle strength and residual urine volume in patients with urinary retention after spinal cord injury were observed by Glazer and bladder volume measurement to compare the electromyography value and residual urine volume of pelvic floor muscles at different stages of resting state and contraction state of the two…","s":"Completed","tr":[],"o":["Bladder Function","Breathing Function","Motor Function","Spasticity"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06964256"},{"n":"NCT00778323","t":"Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery","d":"The purpose of this study is to assess whether a large clinical trial testing the effect of RIPC on neurologic outcome in patients undergoing elective cervical decompression surge is warranted.","s":"Completed","tr":["Surgical Procedure"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00778323"},{"n":"NCT04304976","t":"Clinical Trial ROBERT® - Project Active Training","d":"The overall purpose with this clinical trial is to, monitor and secure ROBERT®'s clinical performance and safety in a clinical environment in the regional hospital North Denmark, Neuro Unit North. The purpose of the study is to investigate if ROBERT® has the ability to 1. Perform guided active training. 2. Perform resistance based active training. And validate the safety of ROBERT® in a clinical environment.","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04304976"},{"n":"NCT02274649","t":"Clinical Trial to Evaluate One-to-one Peer Mentoring","d":"The research will examine the effects of enhanced peer mentor interactions on facilitating a successful transition to community living following traumatic spinal cord injury (SCI). Participants in the research will be assigned to either (1) the control group that will receive traditional peer mentor types of interactions or (2) to the intervention group that will receive an enhanced peer mentor program called the One-on-One Initiative. Assignment to one of these two groups will occur randomly…","s":"Completed","tr":[],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02274649"},{"n":"NCT04148573","t":"Clinical Trial to Evaluate Safety, Tolerability and Efficacy of NFX88 in SCI","d":"In summary, this small-scale study is designed to demonstrate that the NFX88 is safe and well tolerated, as well as preliminary evidence of improvement in the score of VAS, PD-Q, and PGIC scales.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04148573"},{"n":"NCT02923817","t":"Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury","d":"The purpose of study is to determine whether autologous mononuclear cells deriving from the bone marrow are effective in the treatment of spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Vietnam"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02923817","su":"https://scitrials.org/trial/NCT02923817"},{"n":"NCT05883917","t":"Clinical Utility of Robot-Assisted Gait Training in Patients With Spinal Cord Injury Caused by Electrical Burns: A Case Report","d":"Robot-assisted gait training has been effective in several diseases. Nevertheless, evidence supporting the efficacy of such training in burn patients remains insufficient. This report aimed to evaluate the effect of robot-assisted gait training in burn patients with spinal cord injuries caused by electrical trauma. We will report a case of two patients who underwent 30 min of robot-assisted gait training using SUBAR® (Cretem, Korea) with 30 min of conventional physiotherapy, 5 days a week for…","s":"Unknown","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05883917","su":"https://scitrials.org/trial/NCT05883917"},{"n":"NCT01477502","t":"Clinical Value of Homeopathic Prophylaxis of Recurrent Urinary Tract Infections in Persons With Spinal Cord Injury","d":"recurrent symptomatic urinary tracts infections (UTI) in persons with spinal cord injury are a frequent problem, leading to significant morbidity and to a decreased quality of life. * until today, there is no effective prophylaxis for UTI for patients with spinal cord injury. * homeopathy has been shown to be an effective treatment option in several chronic diseases * study hypothesis: the addition of homeopathic assessment and treatment to a standard prevention strategy for recurrent UTI will…","s":"Completed","tr":[],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01477502"},{"n":"NCT04144972","t":"Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain","d":"Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the pain experience and provide continuous 24/7 brain stimulation which may lose effect over time. By developing new technology that targets multiple, complimentary brain regions in an adaptive fashion, the…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04144972","su":"https://scitrials.org/trial/NCT04144972"},{"n":"NCT03029884","t":"Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain","d":"Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but current technology is unable to reliably achieve long-term pain symptom relief. A \"one-size-fits-all\" approach of continuous, 24/7 brain stimulation has helped patients with some movement disorders, but the key to reducing pain may be the activation of stimulation only when needed, as this may help keep the brain from adapting to stimulation effects. By expanding the…","s":"Completed","tr":["Brain Stimulation","Devices"],"o":["Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03029884"},{"n":"NCT04969042","t":"Closed-loop Functional Spinal Cord Stimulation in Patients With Spinal Cord Injury","d":"The purpose of this experiment is to evaluate the efficacy of Closed-loop Functional Spinal Cord Stimulation on Walking Rehabilitation in Patients after Spinal Cord Injury","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04969042","su":"https://scitrials.org/trial/NCT04969042"},{"n":"NCT05267951","t":"Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury","d":"The purpose of this study is to assess the efficacy of non-invasive (transcutaneous) closed-loop electrical spinal cord stimulation for recovery of upper limb function (Aim 1) and spasticity (Aim 2) following spinal cord injury.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement","Spasticity"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05267951","su":"https://scitrials.org/trial/NCT05267951"},{"n":"NCT07689227","t":"Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)","d":"The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in individuals with mobility impairments resulting from chronic, incomplete spinal cord injury (SCI).","s":"Not yet recruiting","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Motor Function","Pain Management","Quality of Life","Walking Function"],"st":["Massachusetts","Texas"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07689227"},{"n":"NCT04309864","t":"CMAP Refinement for Pressure Injury Prevention","d":"For Veterans with spinal cord injury who use a wheelchair, pressure injuries related to sitting are a significant daily threat to well-being. Pressure injuries are costly to treat, negatively impact quality of life and community participation, and can be life threatening. Moving or shifting at regular intervals in the wheelchair redistributes harmful pressure and reduces risk for skin breakdown, yet these movements are a challenge to perform consistently. The challenge exists due to lack of…","s":"Completed","tr":["Devices"],"o":["Mental Health","Pressure Sores","Quality of Life","Sensory Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04309864"},{"n":"NCT03772548","t":"CNS Changes Following SCI","d":"The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following spinal cord injury and how these changes relate to clinical measures. Both macroscopic and microscopic changes of the brain and the spinal cord will be examined in SCI patients and compared to healthy controls. In terms of structural plasticity, we aim to identify MR biomarkers that allow predicting the course of the patient's neurological status…","s":"Recruiting","tr":["Observational"],"o":["Plasticity"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03772548","su":"https://scitrials.org/trial/NCT03772548"},{"n":"NCT01440452","t":"CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies","d":"This research is being done to see how different amounts of Functional Electrical Stimulation (FES) affect cycling on factors in blood and spinal cord in people with spinal cord inflammation.","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Mental Health","Spasticity"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01440452"},{"n":"NCT06364813","t":"Co-developing a Novel Intervention to Promote Wellbeing of Family Caregivers of Individuals With Spinal Cord Injury","d":"Family caregivers of individuals with spinal cord injury (SCI) provide the majority of care and are at high risk of experiencing caregiver burden, which not only impacts caregivers' own wellbeing, but also their ability to respond to patients' needs. Health education using online approaches (eHealth) has the potential to improve quality of care, enhance communication between health care users and providers, reduce costs and increase access to existing knowledge and education for family…","s":"Unknown","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06364813"},{"n":"NCT03898700","t":"Coaching for Caregivers of Children With Spinal Cord Injury","d":"This pilot study has two aims. The first aim is to establish the feasibility of coaching for caregivers of youth with spinal cord injury, and the second aim is to establish methodological procedures for a future multi-center study on the effectiveness of coaching as an intervention for caregivers of youth with spinal cord injury.","s":"Completed","tr":[],"o":["Motor Function"],"st":["Illinois","Pennsylvania","Texas"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03898700"},{"n":"NCT00861393","t":"Cognitive Behavioural Therapy (CBT) For Improving Emotional Well Being in Spinal Cord Injuries (SCI)","d":"The purpose of the study is to determine whether or not a brief psychological treatment called cognitive behaviour therapy will help people who have suffered a spinal cord injury to cope better with their current circumstances.","s":"Unknown","tr":["Rehabilitation"],"o":["Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00861393","su":"https://scitrials.org/trial/NCT00861393"},{"n":"NCT04566809","t":"Cognitive Rehabilitation and FES for Hand Functionality in Persons With Cervical Spinal Cord Injury","d":"16 persons affected by Cervical-SCI were recruited for the study and randomly assigned to the Control Group (CG) or to the Experimental Group (EG). Persons of the CG (n = 8) executed 20 sessions of FES for the rehabilitation of hand functions (grasp or pinch), participants of the EG (n = 8) performed 20 sessions of FES and CBA in addition. The primary assessment was a modified version of Bimanual Activity Test (10 tasks); also, SCIM-II and measurement of grasping strength only in participants…","s":"Completed","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04566809"},{"n":"NCT00715598","t":"Cognitive Testing for the Pain Quality Assessment Scale (PQAS)","d":"The purpose of the study is to improve a questionnaire (the Pain Quality Assessment Scale) used for measuring different types of pain people may experience. An improved version of this questionnaire will help researchers better understand the impact of pain treatments on different types of pain through the use of this questionnaire.","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00715598"},{"n":"NCT04577573","t":"Cognitive-based Prosthetics to Improve Grasp and Reaching After SCI","d":"Rehabilitation of functional movements after spinal cord injury (SCI) requires commitment and engagement to the processes of physical therapy. Outcomes may be improved by techniques that strengthen cognitive connections between users and physical therapy exercises. The investigators will investigate combinations of virtual reality and innovative wearable technology to accelerate rehabilitation of hand grasp and reach. These devices use multi-sensory feedback to enhance the sense of agency, or…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04577573"},{"n":"NCT06734000","t":"Cohorte COSCINUS - Biocollection","d":"COSCINUS is a standardized framework for evaluating temporal trends in SCI causes, SCI characteristics, and demographic patterns. It allows a precise estimation of medical complications' incidence, their evolution over time, as well risk factors influencing these complications, including management modalities. Moreover, COSCINUS provides a high-quality research platform, including clinical, epidemiological, biostatistical, and IT expertise, thereby promoting fundamental research in spinal cord…","s":"Recruiting","tr":["Observational"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06734000","su":"https://scitrials.org/trial/NCT06734000"},{"n":"NCT07101042","t":"Cold vs. Paraspinal Stimulation for Erectile and Urinary Function in SCI Patients","d":"This study is being conducted to compare the effects of two simple treatments-cold therapy and electrical stimulation applied to the lower back-on sexual function and urinary control in men with spinal cord injury (SCI). Many individuals with SCI experience difficulties with erection and urinary leakage, which can negatively affect their quality of life. In this study, participants will be assigned to receive either cold stimulation (using ice massage) or electrical stimulation over the spine…","s":"Not yet recruiting","tr":[],"o":["Bladder Function","Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07101042","su":"https://scitrials.org/trial/NCT07101042"},{"n":"NCT02320786","t":"Collaborative Power Mobility Innovative Learning OpporTunity (CoPILOT) - A Pilot Study of a New Training Approach (Phase 1)","d":"Losing the ability to walk can lead to fewer opportunities to socialize with friends and family and participate in the community. When this happens, powered wheelchairs can provide access to homes and communities, contributing to health and well-being. Training by a qualified occupational therapist allows an individual to use a powered wheelchair safely and effectively. Learning to drive a powered wheelchair can be difficult, frustrating and time consuming for people with cognitive and physical…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02320786"},{"n":"NCT02870426","t":"Collection and Characterisation of Human Olfactory Ensheathing Cells","d":"We aim to retrieve olfactory bulbs (OBs) from suitable human donors. We have defined two groups who will qualify: Group 1 - Deceased Donors: 1A: Donors after brainstem death (DBDs) undergoing solid organ donation 1B: Donors after brainstem death (DBDs) considered unsuitable for solid organ donation Group 2 - Living Donors: Neurosurgical patients undergoing anterior cranial surgery in which the olfactory nerve (ON) is cut as part of the surgical procedure. The OB of the concomitant severed ON…","s":"Unknown","tr":["Observational","Stem Cells","Surgical Procedure"],"o":["Regeneration"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02870426"},{"n":"NCT00371631","t":"Colonizing Neurogenic Bladders With Benign Flora","d":"The purpose of the research is to determine whether we can get harmless bacteria to live in the bladders of persons with spinal cord injury who practice intermittent bladder catheterization. We will also look at whether having the harmless bacteria in the bladder prevents urinary tract infections from occurring.","s":"Completed","tr":[],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00371631"},{"n":"NCT05563103","t":"Combination Therapy to Improve SCI Recovery.","d":"The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.","s":"Recruiting","tr":["Intermittent Hypoxia","Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Illinois","Massachusetts"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05563103","su":"https://scitrials.org/trial/NCT05563103"},{"n":"NCT01621113","t":"Combination Therapy With Dalfampridine and Locomotor Training for Chronic, Motor Incomplete Spinal Cord Injury","d":"The purpose of this study is to determine the efficacy, safety, and tolerability of treatment with dalfampridine in combination with locomotor training in persons with chronic, motor incomplete SCI.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Bladder Function","Bowel Function","Breathing Function","Pain Management","Quality of Life","Sexual Function","Spasticity","Trunk Control","Walking Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01621113"},{"n":"NCT07139496","t":"Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation","d":"Spinal cord stimulation (SCS) has been shown in previous studies to be capable of restoring motor and autonomic function in patients with chronic complete spinal cord injury (SCI). Clinical studies have demonstrated that SCS enables activation of previously paralyzed muscles, leading to functional improvements in patients in the chronic stage of paralysis through the delivery of activity-based interventions. For most previous studies on SCS in SCI, stimulation was invariably applied to…","s":"Recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["Hong Kong"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07139496","su":"https://scitrials.org/trial/NCT07139496"},{"n":"NCT07704268","t":"Combined Magnetic Stimulation and Ultrasound for Detrusor Overactivity in SCI","d":"This clinical trial aims to investigate whether the combination of high-frequency sacral nerve root magnetic stimulation and bladder-directed ultrasound therapy can effectively improve detrusor overactivity (involuntary bladder contractions) and related voiding dysfunctions in patients with spinal cord injury. The main questions it seeks to answer are: What is the effect of high-frequency sacral nerve root magnetic stimulation on detrusor overactivity and bladder function in patients with…","s":"Not yet recruiting","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Bladder Function","Quality of Life","Sensory Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07704268"},{"n":"NCT04276181","t":"Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia","d":"Tetraplegia after a cervical spinal cord injury (C-SCI) radically alters an individual's ability to perform normal activities of daily life due to paralysis in all extremities, resulting in lifelong dependence.\\[1\\] Traditional tendon transfer surgery has proven successful in restoring grip functions which greatly improves autonomy, but with a restricted passive opening of the hand. The number of transferrable muscles in the arm is however limited, why nerve transfer surgery is a new attractive…","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Sweden"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04276181","su":"https://scitrials.org/trial/NCT04276181"},{"n":"NCT03302793","t":"Combined Peripheral (BreEStim) and Central Electrical Stimulation (tDCS) for Neuropathic Pain Management - Spinal Cord Injury","d":"This study looks at the effect of combined breathing-controlled electrical stimulation (BreEStim) and transcranial direct current stimulation (tDCS) on neuropathic pain after spinal cord injury, amputation, or brain injury. The hypothesis is that a single session of combined BreEStim and tDCS will produce an additive analgesic effect. This record covers the study in a population of spinal cord injury patients. Note that this study will also enroll healthy volunteers, brain injury patients, and…","s":"Completed","tr":["Electrical Stimulation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Breathing Function","Pain Management","Sensory Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03302793"},{"n":"NCT03555838","t":"Combined Robotic Training and tDCS in Chronic SCI","d":"The purpose of this study is to establish the value of combined non-invasive stimulation (tDCS) and behavioral training (robotics) in SCI rehabilitation, and understand the mechanisms of this interaction and its relationship to functional outcome. The investigators hypothesize that supplementary tDCS will augment the functional improvement from robot-training, in chronic SCI.","s":"Unknown","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03555838","su":"https://scitrials.org/trial/NCT03555838"},{"n":"NCT07586644","t":"Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI","d":"This clinical trial investigates whether combining cortical and spinal neuromodulation can improve upper limb motor recovery in adults with chronic incomplete cervical spinal cord injury (SCI). Restoring upper limb function is the top rehabilitation priority for individuals with tetraplegia, yet effective interventions remain limited. The study combines transcutaneous spinal cord stimulation (tSCS), which enhances spinal circuit excitability, with intermittent theta burst stimulation (iTBS), a…","s":"Not yet recruiting","tr":["Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Arm Movement"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07586644","su":"https://scitrials.org/trial/NCT07586644"},{"n":"NCT02554058","t":"Combined Tactile and Proprioception Training After Spinal Cord Injury","d":"A novel rehabilitation bike has been developed for patients with incomplete spinal cord injuries that incorporates mechanical stimulators on the bike pedals to stimulate the sensory receptors in the soles of the feet; the effect of mechanical stimulator on muscle strengthening has been reported by NASA to improve muscle atrophy in astronauts in zero-gravity environments. Cycling also stimulates lower limb position sensors. We predict that the combination of mechanical stimulation with cycling…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Sensory Function","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02554058"},{"n":"NCT06101199","t":"Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury","d":"The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of carbon dioxide (CO2), interspaced by breathing room air. The technical name for this therapeutic air mixture is 'acute intermittent hypercapnic-hypoxia,' abbreviated as AIHH. Following exposure to the gas mixture, participants will receive non-invasive electrical…","s":"Terminated","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Blood Pressure","Breathing Function","Hand Movement","Motor Function"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06101199"},{"n":"NCT07429305","t":"Combined Tibial Nerve Stimulation and Standing for People With SCI","d":"The goal of this clinical trial is to understand how sensory inputs from the lower leg can influence pelvic floor muscle function and urogential function in adults with chronic spinal cord injury (SCI). The main questions it aims to answer are: 1. What is the modulatory role of load and posture on reflex activation of the pelvic floor muscles in participants with SCI? 2. What is the feasibility of combining tibial neuromodulation with standing therapy in participants with SCI? 3. What are the…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07429305","su":"https://scitrials.org/trial/NCT07429305"},{"n":"NCT07595497","t":"Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI","d":"he goal of this clinical trial is to learn if combined brain and spinal cord stimulation using TMS-tSCS can improve leg strength and walking recovery in adults with chronic incomplete spinal cord injury. The main questions it aims to answer are: Does combined TMS-tSCS improve lower limb motor function more than tSCS alone? Is combined TMS-tSCS safe and does it improve walking speed, independence, muscle activity, spasticity, and nerve pathway function? Researchers will compare combined TMS-tSCS…","s":"Not yet recruiting","tr":["Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Leg Movement","Walking Function"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07595497","su":"https://scitrials.org/trial/NCT07595497"},{"n":"NCT05217498","t":"Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury","d":"Breathing brief, moderate bouts of low oxygen trigger (low oxygen therapy, LOT) spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new experiences), and improve walking after spinal cord injury (SCI). The greatest improvements in walking ability occur when LOT is administered prior to skill-based walking practice (WALK). However, the enduring benefits of LOT on walking recovery may be undermined by the accumulation of LOT-induced increase in…","s":"Not yet recruiting","tr":["Intermittent Hypoxia","Rehabilitation"],"o":["Walking Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05217498","su":"https://scitrials.org/trial/NCT05217498"},{"n":"NCT06773286","t":"Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury","d":"The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training (ABT) and spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hands, arms, and trunk in an inpatient rehabilitation program. The main questions it aims to answer are: * Is the combination of spinal cord transcutaneous stimulation…","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06773286","su":"https://scitrials.org/trial/NCT06773286"},{"n":"NCT02862080","t":"Combining tsDCS and Exoskeleton Gait Training on Spinal Excitability in SCI","d":"The purpose of the study is to determine whether transcutaneous spinal direct current stimulation (tsDCS) is safe for individuals with spinal cord injury (SCI). tsDCS is an electrical current applied to the skin. The plan is to also study the potential neurophysiological changes (changes in speed and excitability of the nerves) and functional improvements in gait (for example, gait quality, speed and walking distance) for individuals with SCI after combined application of tsDCS and exoskeleton…","s":"Completed","tr":["Exoskeleton","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02862080"},{"n":"NCT05386537","t":"Combining Wearable Robotic Orthosis With Visual and Haptic Feedback to Enhance the Recovery of Upper Extremity Motor Function and ADL in Persons With Acute SCI","d":"This randomized clinical trial (RCT) is evaluating the usefulness of combining MyoMo robotic orthosis with visual and haptic feedback in ameliorating wrist/hand/UE movement capability, and increasing ADL and quality of life in people with acute SCI.","s":"Unknown","tr":["Exoskeleton"],"o":["Hand Movement"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05386537","su":"https://scitrials.org/trial/NCT05386537"},{"n":"NCT05035823","t":"COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis","d":"The Synchron motor neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex. The purpose of this research is to evaluate safety and feasibility. The MNP is a type of implantable brain computer interface which bypasses dysfunctional motor neurons. The device is designed to restore the transmission of neural signal from the cerebral cortex utilized for neuromuscular control of…","s":"Active, not recruiting","tr":["Brain Stimulation"],"o":[],"st":["New York","Pennsylvania"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05035823","su":"https://scitrials.org/trial/NCT05035823"},{"n":"NCT02006901","t":"Comparative Effectiveness of Microdecompression and Laminectomy for Central Lumbar Spinal Stenosis","d":"Introduction: This observational study is designed to test the equivalence between the clinical effectiveness of microdecompression and laminectomy in the surgical treatment of central lumbar spinal stenosis. Lumbar spinal stenosis is the most frequent indication for spinal surgery in the elderly, and as the oldest segment of the population continues to grow its prevalence is likely to increase. However, data on surgical outcomes are limited. Open or wide decompressive laminectomy, often…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Quality of Life"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02006901"},{"n":"NCT00318591","t":"Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections","d":"The purpose of this study is to investigate the frequency of urinary tract infections with symptoms in spinal cord injured patients requiring intermittent catheterization for emptying the bladder. Patients will use either a coated catheter or an uncoated catheter with gel.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["California","Colorado","Florida","Georgia","Massachusetts","Michigan","Minnesota","New Jersey","New York","North Carolina","Texas"],"co":["Canada","United States"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00318591"},{"n":"NCT00800462","t":"Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity","d":"This is a phase IV, double-blind, multicenter, randomized trial evaluating the efficacy and safety of two M3 receptors antagonists (Trospium Chloride and Darifenacin Hydrobromide) with one standard drug (Oxybutynin Chloride) for treatment of overactive bladder in individuals with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00800462"},{"n":"NCT06818604","t":"Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries","d":"Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%. The condition often leads to daytime sleepiness, fatigue, and poor participation in rehabilitation. Positive airway pressure therapy can be used to treat the condition; however, some individuals find continuous positive airway pressure (CPAP), which applies the same pressure during inhalation and exhalation, difficult to use. Bilevel…","s":"Not yet recruiting","tr":[],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06818604","su":"https://scitrials.org/trial/NCT06818604"},{"n":"NCT06828653","t":"Comparing Digitally and Traditionally Made Ankle Foot Orthoses","d":"The research is being done to compare two methods of creating AFOs: 1. The traditional method, which involves manually creating a mold from a plaster cast of the client's limb. This is time-consuming and labor-intensive; and 2. The newer method uses digital technology, such as 3D scanning and printing, to design and produce the AFOs, potentially making the process faster and less costly. We want to know whether AFOs made using digital technology can provide the same clinical benefits as those…","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06828653","su":"https://scitrials.org/trial/NCT06828653"},{"n":"NCT02089880","t":"Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis","d":"The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic disease or trauma, as compared to the stance control orthosis.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02089880","su":"https://scitrials.org/trial/NCT02089880"},{"n":"NCT01204736","t":"Comparing Outcomes of Elbow Extension Tendon Transfers","d":"Active elbow extension has significant functional benefits for individuals with tetraplegia. The proposed work will provide information to assess how effectively people are using their elbow extension tendon transfers, and whether one surgery works more effectively than the other. This study will provide recommendations to clinicians about the possibility of improving function after surgery using rehab techniques.","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Arm Movement","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01204736"},{"n":"NCT01367405","t":"Comparing Surgical Decompression Versus Conservative Treatment in Incomplete Spinal Cord Injury","d":"Traumatic Central Cord Syndrome (TCCS) was until recent recognized as a separate clinical entity. The most characteristic feature is the disproportionate more motor impairment of the arms and especially the hands than the legs, bladder dysfunction and sensory. Recently, it has been shown that the distinction of TCCS with an incomplete cervical spinal cord lesion (ICSCL) is artificial. It is the most frequent incomplete traumatic spinal cord lesion. It accounts for up to 70 % of all incomplete…","s":"Terminated","tr":["Surgical Procedure"],"o":["Bladder Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01367405"},{"n":"NCT07237386","t":"Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations","d":"Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment. This can provide a more realistic picture of gait patterns compared to measurements taken in a laboratory setting. At UZ Ghent, we use an advanced gait lab to measure gait parameters before and after a training period on this system, the GRAIL system. We measure similar parameters to the…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Belgium"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07237386"},{"n":"NCT06733025","t":"Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study","d":"Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence. Spasticity affecting the hand is particularly debilitating because it prevents prehension and grasp, which are critical factors for the ability to perform activities of daily living independently. Spasticity is described as one of the prominent secondary conditions in individuals with…","s":"Recruiting","tr":[],"o":["Hand Movement","Spasticity"],"st":[],"co":["Sweden"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06733025","su":"https://scitrials.org/trial/NCT06733025"},{"n":"NCT03544398","t":"Comparison of an Exoskeleten With an End-effector for Assisted Gait Training in Spinal Cord Injury","d":"Aim is to compare exoskeleton assisted gait training with end-effector assisted gait training in Spinal Cord Rehabilitation","s":"Unknown","tr":["Exoskeleton"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03544398","su":"https://scitrials.org/trial/NCT03544398"},{"n":"NCT06169657","t":"Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury","d":"The purpose of the project is to compare intensity (minutes in target heart rate zone) and steps per session across three gait training modalities, including body-weight supported treadmill training (BWSTT), overground gait training with body weight-support (BWS), and overground gait training utilizing a lower extremity exoskeleton, between patients presenting with varying functional ambulation capacities in the inpatient setting. Additionally, the researchers will compare physical therapist…","s":"Withdrawn","tr":["Exoskeleton","Observational","Rehabilitation"],"o":["Leg Movement","Pain Management","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06169657"},{"n":"NCT01433159","t":"Comparison of HP011-101 to Standard Care for Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury","d":"The trial will compare the effects of 14 days treatment with HP011 101 versus Standard Care in subjects with Stage I or II pressure ulcers as a complication of spinal cord injury, measured as change from baseline in composite wound bed scores of the PUSH 3.0 tool.","s":"Terminated","tr":["Drugs"],"o":["Pressure Sores"],"st":["California","Florida","New Jersey","North Carolina"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01433159"},{"n":"NCT01407354","t":"Comparison of Lokomat and Aquatic Exercise for Individuals With Chronic Incomplete Spinal Cord Injury","d":"Many people with spinal cord injury (SCI) hold some ability to move their leg muscles, and are therefore considered to demonstrate a motor incomplete injury. After such a spinal cord injury, individuals are able to walk less both in their home and in their community. De-conditioning, or a lack of endurance and fitness also occurs. Several methods are available to try to improve walking ability and the fitness of persons with motor incomplete spinal cord injury. This study examines two of these…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Walking Function"],"st":["Georgia","Maryland"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01407354"},{"n":"NCT04912583","t":"Comparison of Low and High Tidal Volumes in Acute Spinal Cord Injury","d":"Objective: This study's primary objective is to evaluate the efficacy and feasibility of mechanical ventilation with high vs. low tidal volume (Vt) in people with acute spinal cord injury (SCI). Secondary objectives include a comparison of inflammatory markers between these groups. Study Design: Randomized comparative effectiveness trial Methods: Study population: Adults with acute traumatic SCI on mechanical ventilation (MV). Subjects will be randomized to receive either a lower Vt of 8-10…","s":"Completed","tr":["Devices"],"o":["Breathing Function"],"st":["Colorado","Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04912583"},{"n":"NCT05118971","t":"Comparison of Muscle Activity in Exercise Bike and Elliptical Trainer in Individuals With Spinal Cord Injury","d":"Spinal cord injury is caused by any harmful process in the spinal cord, impairing its function, generating loss of muscle strength, impairing orthostatism and walking. In rehabilitation, some strategies are used to activate the muscles involved in the gait of these individuals, including the ergometric bicycle and the elliptical. Understanding the pattern of muscle activation generated by these methods is important to answer questions arising from clinical practice. Thus, we seek to verify the…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Brazil"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05118971"},{"n":"NCT04360447","t":"Comparison of Pilates &Home Exercise Programs on Muscle Strength in Paraplegic Patients","d":"Paraplegic patients to be included in the study were divided into 2 groups by randomization and it was planned to apply reformer pilates or home exercise programs for 8 weeks. It was aimed to compare upper extremity muscle strengths, Spinal Cord Independence Measure version III (SCIM-III) and the Short Form(36) Health Survey (SF-36) data before and after treatment.","s":"Completed","tr":["Devices"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04360447"},{"n":"NCT01095380","t":"Comparison of Post-pinal Cord Injury (SCI) Locomotor Training Techniques","d":"Background: Body weight supported (BWS) locomotor training improves overground walking ability in individuals with motor-incomplete spinal cord injury (SCI). While there are various approaches available for locomotor training, there is no consensus regarding which of these is optimal. The purpose of this ongoing investigation is to compare outcomes associated with these different training approaches. Subjects and Methods: Subjects with chronic motor-incomplete SCI have completed training and…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01095380"},{"n":"NCT00047580","t":"Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.","d":"This study is being conducted to compare the impact of somnolence (sleepiness) on cognition (awareness) as well as the safety and effectiveness of tizanidine hydrochloride capsules versus Zanaflex® (tizanidine hydrochloride tablets) taken while in the fed state (just after a meal) and in the fasted state (before a meal) in patients with moderate to severe spasticity.","s":"Completed","tr":["Drugs"],"o":["Spasticity"],"st":["Arizona","California","Colorado","Connecticut","Florida","Georgia","Illinois","Minnesota","Oklahoma","Oregon","Rhode Island"],"co":["United States"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00047580"},{"n":"NCT06912217","t":"Comparison of the Effects of Robotic Rehabilitation, Functional Electrical Stimulation and Occupational Therapy on Upper Extremity and Hand Functions in Tetraplegic Patients With Spinal Cord Injury","d":"2\\. Purpose and Significance of the Study (Primary and Secondary Objectives, if any) Spinal cord injury (SCI) is a clinical condition characterized by partial or total loss of motor, sensory, and autonomic functions below the level of the lesion, depending on the severity and level of the injury, which may be caused by traumatic or non-traumatic factors. Globally, the incidence of SCI is estimated to be 250,000-500,000 cases per year . SCI patients may be classified as tetraplegic or paraplegic…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Turkey (Türkiye)"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06912217"},{"n":"NCT02244931","t":"Comparison of Three Different Assisting Devices to Power Manual Wheelchairs in Patients With Spinal Cord Injury","d":"The purpose of this study is to compare three assisting devices to propel personal wheelchairs (Servomatic A©, Servomatic B© and E.Motion©) to the standard personal manual wheelchair in patients with spinal cord injury.","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02244931"},{"n":"NCT04043715","t":"Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function","d":"Incomplete spinal cord injuries (SCI) are the most frequent neurologic category, comprising 66.7% of all SCI cases. People with incomplete SCI may retain some ability to move the legs and therefore the capacity to regain walking. Studies that show functional improvement in locomotion via electrical stimulation of lumbosacral circuits suggest that the underlying mechanisms are neuromodulation of lumbosacral spinal cord automaticity and sensory feedback. Both epidural and transcutaneous spinal…","s":"Withdrawn","tr":["Electrical Stimulation","Epidural Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function","Leg Movement","Quality of Life","Sexual Function","Trunk Control","Walking Function"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04043715"},{"n":"NCT02161913","t":"Comparison of Two Psycho-educational Family Group Interventions for Persons With SCI and Their Caregivers","d":"Each year over 12,000 spinal cord injuries (SCI) occur in the United States. These injuries result in incredibly difficult, long-term, life adjustments both for patients and their caregivers. Many families continue to struggle with the physical, emotional and social impacts of SCI for months and years after the injury. Family education and support improves the outcomes of other challenging long-term conditions such as Traumatic Brain Injury, but little effort has been made to provide such…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02161913"},{"n":"NCT04827095","t":"Comparison of Two Web-Based Education/Support Programs for Partner Caregivers of People With Spinal Cord Injury","d":"The purpose of this research study is to compare the effect of two different types of education and support programs for partner caregivers of people with spinal cord injury (SCI).","s":"Unknown","tr":[],"o":["Mental Health"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04827095","su":"https://scitrials.org/trial/NCT04827095"},{"n":"NCT07015099","t":"Complications Associated With Delayed Admission to Spinal Injury Unit","d":"The aim of this study is to determine the prevalence of complications including PUs at time of admission to a regional spinal injury rehabilitation unit (MCSI), the relationship between wait time to admission for specialist SCI rehabilitation and complication n occurrence, neurological recovery, and length of stay. The hypothesis is that wait time to transfer from the acute hospital to the specialised SCI rehabilitation unit is associated with increased PU prevalence and other SCI…","s":"Not yet recruiting","tr":["Observational","Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07015099"},{"n":"NCT05071885","t":"Computer Game-based Exercise Program Targeting Manual Dexterity for People With Spinal Cord Injury or Stroke.","d":"Recovery programs of the upper extremity can be extensive, for many adults with neurological disorders/injuries, including maintenance exercises that need to be done continually to maintain function and to prevent secondary disabilities. However increasing demands and shrinking funds are making it harder to meet the rehabilitation needs of Manitobans and Canadians with chronic disabilities. There is a need for innovation to improve the accessibility and engagement of rehabilitation programs for…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05071885"},{"n":"NCT05351333","t":"Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation","d":"The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effects as well as the risk of addiction associated with opioid treatment.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Mental Health","Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05351333"},{"n":"NCT02611375","t":"Conditioning Neural Circuits to Improve Upper Extremity Function","d":"Non-invasive brain stimulation has gained increasing popularity and research support over the past several years. Recent research indicates that it might have benefits for improving hand function in people with spinal cord injury. The purpose of this study is to evaluate the effects of a type of non-invasive brain stimulation, known as tDCS, on hand function.","s":"Completed","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02611375"},{"n":"NCT07357428","t":"Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)","d":"The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI). The Connexus BCI is intended to be used as: (1) an assistive communication device to decode imagined language correlates and speech for patients with impaired communication as a result of severe loss of voluntary motor control; and (2) to provide control of computer devices for individuals with severe loss of voluntary motor control of the upper…","s":"Recruiting","tr":["Brain Machine Interface (BMI)"],"o":[],"st":["California","Massachusetts","Michigan"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT07357428","su":"https://scitrials.org/trial/NCT07357428"},{"n":"NCT03626324","t":"Connected Catheter (C2P) Study for Bladder Management","d":"The objective of this study is to evaluate the safety and essential performance of the C2P System in males with neurogenic lower urinary tract dysfunction (NLUTD), both in an acute clinical setting and an extended period of home use.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["Arizona","California","Minnesota","New Jersey"],"co":["United States"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03626324"},{"n":"NCT04059159","t":"Connected Catheter - Safety and Effectiveness Study","d":"The Connected Catheter is a fully internal, urethral indwelling urinary prosthesis designed for improved bladder management in males with urinary retention disorders requiring catheterization. It is a sterile, extended-use device that resides fully internally to the male lower urinary tract for an intended use life of up to 7 days per catheter.","s":"Terminated","tr":["Devices"],"o":["Bladder Function"],"st":["California","District of Columbia"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04059159"},{"n":"NCT03405285","t":"Connected Catheter Clinical Feasibility Study( CFS)","d":"The objective of this study is to evaluate the safety and essential performance of the Connected Catheter System in males with neurogenic lower urinary tract dysfunction (NLUTD), both in an acute clinical setting, and during and extended period (up to 29 days) of home use.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["California"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03405285"},{"n":"NCT03843073","t":"Connected Catheter- Safety and Effectiveness Study","d":"The Connected Catheter is a fully internal, urethral indwelling urinary prosthesis designed for improved bladder management in males with urinary retention disorders requiring catheterization. It is a sterile, extended-use device that resides fully internally to the male lower urinary tract for an intended use life of up to 7 days per catheter.","s":"Terminated","tr":["Devices"],"o":["Bladder Function","Quality of Life"],"st":["California","Maryland","Minnesota","New Jersey","New York","Texas"],"co":["United States"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03843073"},{"n":"NCT05906056","t":"Continuous Passive Motion Versus Heterotopic Ossification","d":"The investigators hypothesize that Heterotopic Ossification (HO) formation can be suppressed if the application of a Continuous Passive Motion (CPM) device can be performed for a substantial amount of time. The investigators will use the following study design: a pilot study with 10 ICU patients receiving CPM and 10 matched cases which will follow a conventional physiotherapy program at the time of the conduction of the study. The comparison between the treatment and referent groups of the…","s":"Recruiting","tr":["Devices","Drugs","Rehabilitation"],"o":[],"st":[],"co":["Greece"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05906056"},{"n":"NCT06654804","t":"Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury","d":"Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypoperfusion of the spinal cord and exacerbates the severity of injury. This is also referred to as secondary injury. Thus, knowledge of…","s":"Recruiting","tr":["Drugs","Surgical Procedure"],"o":["Blood Pressure"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06654804","su":"https://scitrials.org/trial/NCT06654804"},{"n":"NCT06710626","t":"Control of Assistive Devices Via Brain-Computer Interface Technology","d":"The CONVOY Study is a clinical trial designed to explore the feasibility of participants from the PRIME Study (NCT06429735) using the N1 Implant to control various assistive devices. The main goal is to determine whether participants can successfully modulate their brain activity to control devices, such as an Assistive Robotic Arm (ARA). This study will assess the effectiveness, consistency, and safety of neural control using the ARA and other assistive devices.","s":"Enrolling by invitation","tr":["Brain Machine Interface (BMI)"],"o":[],"st":["Arizona"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06710626","su":"https://scitrials.org/trial/NCT06710626"},{"n":"NCT00204113","t":"Control of Unsupported Paraplegic Standing","d":"The study will investigate the feasibility of using functional electrical stimulation (FES) of the calf muscles of paraplegic subjects to assist in posture stabilisation during standing. We aim to achieve postural stability by combining controlled FES of the lower-limb muscles with the voluntary motor control skills of the intact upper body.","s":"Unknown","tr":["Functional Electrical Stimulation (FES)"],"o":["Motor Function","Trunk Control","Walking Function"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00204113","su":"https://scitrials.org/trial/NCT00204113"},{"n":"NCT04369131","t":"Controlling Orthostatic Hypotension in People with Cervical Spinal Cord Injury","d":"A common therapeutic intervention after spinal cord injury (SCI) is prolonged standing in a standing frame. For people with SCI, standing for 40 minutes or more, three to four times weekly improves several health-related issues including well-being, circulation, skin integrity, reflex activity, bowel and bladder function, digestion, sleep, pain, and fatigue. However, a person who experiences orthostatic hypotension (OH)-defined as a decrease of 20mm hg in systolic blood pressure or a decrease…","s":"Withdrawn","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Bladder Function","Blood Pressure","Bowel Function","Mental Health","Pain Management"],"st":["Nebraska"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04369131"},{"n":"NCT05693181","t":"Cord Blood Cells in Patients With Acute SCI","d":"This is a prospective, single-blinded, single-center, randomized, comparative, interventional clinical study of systemic mononuclear multiple allogenic cord blood cells administration safety and efficiency in patients having acute severe contusion spinal cord injury (ASIA A/B), phase I/II","s":"Unknown","tr":["Safety"],"o":["Regeneration"],"st":[],"co":["Russia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05693181","su":"https://scitrials.org/trial/NCT05693181"},{"n":"NCT02007226","t":"Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury","d":"Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD has not been performed prospectively in those with SCI. CHD is a leading cause of death in spinal cord injury, occurring at younger ages than in the able-bodied population. Conventional risk factors for CHD are high serum concentrations of low-density lipoprotein (LDL)…","s":"Completed","tr":["Observational"],"o":[],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02007226"},{"n":"NCT01065896","t":"Coronary Computed Tomography (CT) to Measure Coronary Calcification in Spinal Cord Injury (SCI)","d":"Although conventional risk factors for coronary heart disease (CHD) have been identified and routinely used to determine risk for CHD in the general population, a systematic approach to determine population-specific risk for CHD has not been performed prospectively in those with SCI. CHD is a leading cause of death in spinal cord injury, occurring at younger ages than in the able-bodied population. Conventional risk factors for CHD are high serum concentrations of low-density lipoprotein (LDL)…","s":"Completed","tr":["Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01065896"},{"n":"NCT00628446","t":"Coronary Heart Disease as Measured by Coronary Calcium Score Among Individuals With Chronic Traumatic Spinal Cord Injury","d":"This study includes male subjects age 45 to 70, who have sustained a traumatic Spinal Cord Injury (SCI) at least 10 years prior. Subjects will be interviewed for demographic data, including heart disease risk factors. A blood test for cholesterol levels will be drawn. A CT scan of arteries of the heart will be performed to determine the presence of coronary calcium, a marker of subclinical Coronary Heart Disease. Scoring of Coronary Calcium or Coronary Calcium Score (CCS) is automated by the CT…","s":"Completed","tr":["Observational"],"o":[],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00628446"},{"n":"NCT06680063","t":"Correlation Between Clinical Assessment and Neurophysiological Assessment in Spinal Cord Injury","d":"This study is a cross-sectional study that aims to explore the correlation between clinical assessment and neurophysiological assessment in SCI. The clinical outcome assessment are modified-Modified Ashworth scale (m-MAS) and lower extremity motor score. The neurophysiological outcome is H-reflex outcome.","s":"Completed","tr":["Observational"],"o":["Leg Movement","Motor Function","Spasticity"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06680063"},{"n":"NCT03114345","t":"Correlation Between Pressure Differences and Micro-vascularization Changes in Bedridden Paraplegic Patient","d":"Paraplegic patients have defective wound healing for sore below the level of spinal lesion. Defect of vascularization of the healing zone certainly participate to this effect. Therefore, this study want to measure, in a clinical settings, the interface pressure (e.g. the pressure between the patient body and the surface he/she is lying on) to assess the correlation between mechanical stress in term of pressure applied over time and tissue oxygenation which represent micro-vascular function. The…","s":"Terminated","tr":["Devices","Surgical Procedure"],"o":["Pressure Sores"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03114345"},{"n":"NCT07419165","t":"Correlation of Ultrasound-Measured Detrusor and Bladder Wall Thickness With Urodynamic Parameters in Spinal Cord Injury","d":"This study aims to investigate the correlation between detrusor and bladder wall thickness measured by suprapubic ultrasound and urodynamic parameters in patients with spinal cord injury. By evaluating ultrasonographic measurements alongside urodynamic findings, the study seeks to assess their relationship in a prospective cross-sectional setting.","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07419165"},{"n":"NCT03833518","t":"Cortical Biomarkers of Hand Function and Recovery After Injury","d":"This is a pilot study to collect data to support a VA grant submission to study fMRI and neurophysiological predictors of hand function and recovery during a robotic intervention in people with hand impairments due to stroke or spinal cord injury.","s":"Terminated","tr":["Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement","Motor Function"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03833518"},{"n":"NCT01894802","t":"Cortical Recording and Stimulating Array Brain-Machine Interface","d":"The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["Illinois","Pennsylvania"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT01894802","su":"https://scitrials.org/trial/NCT01894802"},{"n":"NCT03014999","t":"Corticospinal Excitability After rTMS in Spinal Cord Injury Patients","d":"A crossover trial with spinal cord injury volunteers will be conducted. Three sessions will be performed once a week in a counterbalanced order and at least with seven days washout period to minimize carry-over effects. In each session, volunteers will be submitted to quantity and quality of sleep, type of eating, fatigue and motivation level, Ashworth scale spasticity, cortical brain activity measures through simple pulse transcranial magnetic stimulation (pTMS), spinal cord activity measures…","s":"Completed","tr":["Electrical Stimulation","Transcranial Magnetic Stimulation (TMS)"],"o":["Plasticity","Spasticity"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03014999"},{"n":"NCT02451683","t":"Corticospinal Function After Spinal Cord Injury","d":"The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal cord injury (SCI). The investigator proposes to use modern electrophysiological methods to enhance the efficacy of residual corticospinal connections. Defining the neural basis by which corticospinal volleys generate muscle responses will provide crucial information…","s":"Completed","tr":[],"o":["Arm Movement","Hand Movement","Leg Movement","Motor Function","Plasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02451683"},{"n":"NCT04592679","t":"Cost-Effectiveness Analysis of a Rehabilitation Protocol With FES Cycling in Persons With Complete SCI","d":"20 patients were recruited by two hospitals (AOUP and AOUC) in Italy from January 2015 to January 2018. The participants have been addressed to two different groups: the ones recruited by the AOUP were submitted to an experimental protocol of rehabilitation with FES Cycling, the ones recruited by the AOUC were submitted to a standard protocol of manual mobilization. The primary outcome was the thigh circumferences measured at 4 different levels (5-10-15-20 cm) from the superior margin of the…","s":"Completed","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Pain Management","Sensory Function","Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04592679"},{"n":"NCT07643974","t":"Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD","d":"The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \\& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \\& Lactobacillus instillations.","s":"Not yet recruiting","tr":["Drugs"],"o":["Bladder Function"],"st":["District of Columbia","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07643974","su":"https://scitrials.org/trial/NCT07643974"},{"n":"NCT02099357","t":"Creatine or Vitamin D Supplementation in Persons With Spinal Cord Injury Undergoing Resistance Training","d":"The purpose of this study is to determine the effects of creatine monohydrate or vitamin D supplementation on strength gains following a traditional resistance training program for adults with spinal cord injury.","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Motor Function"],"st":[],"co":["Portugal"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02099357"},{"n":"NCT04917107","t":"CREATION: A Clinical Trial of Qigong for Neuropathic Pain Relief in Adults With Spinal Cord Injury","d":"Between 39-67% of the 294,000 Americans who have a SCI suffer from long-term debilitating neuropathic pain, interfering with rehabilitation, general activity, mobility, mood, sleep, and quality of life. Pain can hinder any potential for functional improvement that could be obtained during rehabilitation. Yet, neuropathic pain is refractory to many treatments. Current interventions, such as medications and physical therapy, result in less than 50% reduction in pain for only about one third of…","s":"Terminated","tr":[],"o":["Pain Management"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04917107","su":"https://scitrials.org/trial/NCT04917107"},{"n":"NCT07109804","t":"Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury","d":"This is a study about deep brain stimulation (DBS) as an investigational treatment for walking impairment following spinal cord injury (SCI). The purpose of this study is to assess the feasibility and inform on the safety, and efficacy of CnF DBS to improve gait in SCI patients with incomplete injury who cannot effectively walk overground","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["Florida"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07109804","su":"https://scitrials.org/trial/NCT07109804"},{"n":"NCT04832802","t":"Customized Employment for Veterans With Spinal Cord Injury","d":"The reason for conducting this study is to learn about the best ways to help Veterans with spinal cord injury (SCI) gain meaningful employment. Spinal cord injury is a medically complex disability that poses unique barriers to employment for Veterans. Returning to work after SCI improves health and quality of life, which in turn can lower risk for suicide in this high-risk population. Hence, the Department of Veterans Affairs (VA) supports interventions that help Veterans with SCI return to…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Florida","Virginia"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04832802"},{"n":"NCT01509885","t":"Cyproheptadine and Chlorpromazine Effects on Spasticity","d":"The main goal of this research is to understand the neuronal mechanisms that mediate the development of spasticity and motor dysfunction after spinal cord injury. The investigators examine how neurons and neuronal circuits in an injured nervous system adapt to produce the uncontrolled and unwanted muscle contractions that affect the majority (80%) of patients with spinal cord injury. One of the neurons that the investigators study is the motoneuron that excites the muscles of the limbs to…","s":"Completed","tr":["Observational"],"o":["Blood Pressure","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01509885"},{"n":"NCT06445426","t":"Cystometry Using a Novel Microsensor System in Patients With Neurogenic Bladder Dysfunction","d":"The aim of this study is to assess the feasibility and safety of a novel system for percutaneous measurement of bladder pressure. This system enables minimally invasive procedures and high-quality recordings, offering a sampling rate and synchronization surpassing traditional methods. The pressure sensor system has the potential to be developed into a low-cost method suitable for mass production. The study will include a sample of convenience of up to 40 subjects. Pressure will be recorded…","s":"Completed","tr":["Devices","Observational"],"o":["Bladder Function"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06445426"},{"n":"NCT03262766","t":"Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI","d":"The purpose of this research study is to investigate the effectiveness of a combinatorial therapy of breathing low oxygen in short bursts-acute intermittent hypoxia (AIH) and upper limb training on arm strength and function, and comparing it with individual treatments in persons with spinal cord injuries. The investigators hypothesize that a combinatorial intervention with AIH therapy + upper limb training will be significantly more effective in improving hand function, compared to individual…","s":"Unknown","tr":["Intermittent Hypoxia"],"o":["Arm Movement","Hand Movement"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03262766","su":"https://scitrials.org/trial/NCT03262766"},{"n":"NCT02336321","t":"Daily-life Brain Control Of A Hand Exoskeleton After Cervical Spinal Cord Injury","d":"In this study, 6 volunteer participants with chronic spinal cord injury will be invited to use an autonomous hand exoskeleton device controlled by a brain/neural-computer interaction (BNCI) system fusing electroencephalography (EEG) and electrooculography (EOG) to detect the intention of the user to grasp objects of daily life. The BNCI system consists of a lightweight hand exoskeleton connected to portable motors, rechargeable batteries and a computerized control system integrated into a…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Hand Movement","Mental Health","Motor Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02336321"},{"n":"NCT04325165","t":"DBS of PPN to Improve Walking in Chronic SCI Patients","d":"Spinal cord injury (SCI) is a devastating condition affecting over 1 million individuals in North America. SCI often results in severe motor impairments with few available treatments options. Recent groundbreaking research has demonstrated that deep brain stimulation (DBS) of the mesencephalic locomotor region (MLR) greatly improves locomotion in a rat model with incomplete SCI. The pedunculopontine nucleus (PPN - a specific nucleus within the MLR) in humans has already been established as an…","s":"Withdrawn","tr":["Brain Stimulation","Devices"],"o":["Motor Function","Pain Management","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04325165"},{"n":"NCT07012135","t":"Deciphering Preserved Autonomic Function After Multiple Sclerosis","d":"This study looks to characterize gradients of dysfunction in the autonomic nervous system in patients with clinically diagnosed multiple sclerosis. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with multiple sclerosis typically suffer. Focusing on blood pressure regulation, the most precise metric with broad clinical applicability, the investigators will perform laboratory-based tests to probe the…","s":"Recruiting","tr":[],"o":["Bladder Function","Blood Pressure"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07012135"},{"n":"NCT04493372","t":"Deciphering Preserved Autonomic Function After Spinal Cord Injury","d":"This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically suffer. Focusing on blood pressure regulation, the most precise metric with broad clinical applicability, the investigators will perform laboratory-based tests to probe the body's ability to generate…","s":"Recruiting","tr":[],"o":["Blood Pressure"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04493372","su":"https://scitrials.org/trial/NCT04493372"},{"n":"NCT02016768","t":"Decompressive Cervical Surgery and Hypertension","d":"There is a relationship between CSM and hypertension, probably a cause/effect relationship, and investigators term this type of hypertension \"cervicogenic hypertension\". Abnormally functioning serotonergic pacemaker cells in the dorsal raphe nucleus inappropriately activate and inhibit parts of the central and autonomic nervous systems as part of a chronic stress response, which causes hypertension and migraine. This theory is now being expanded to encompass both CSM and essential hypertension…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Blood Pressure","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02016768"},{"n":"NCT03053791","t":"Deep Brain Stimulation in Patients With Incomplete Spinal Cord Injury for Improvement of Gait","d":"Spinal cord injuries are anatomically mostly incomplete, showing tissue bridges of the spinal cord at the injury site. Of the 60% functionally incomplete patients, about half face a life in the wheelchair. Besides conventional rehabilitation, no prominsing further treatment options exist. One of the most plastic systems involved in locomotion is the pontomedullary reticulospinal tract, which is the oldest locomotor command system existing in most vertebrates, including primates. Muscle…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03053791","su":"https://scitrials.org/trial/NCT03053791"},{"n":"NCT04965727","t":"Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury","d":"The purpose of this study is to evaluate safety of Deep Brain Stimulation (DBS) of the lateral hypothalamus (LH) and whether the use of DBS can increase motor performance in patients with chronic spinal cord injury (SCI). The hypothesis, based on preclinical findings, is that DBS of the lateral hypothalamus can acutely augment leg motor function after SCI, and that the use of lateral hypothalamus DBS can be an adjunct during rehabilitation to promote recovery and long-term neuroplasticity.","s":"Unknown","tr":["Brain Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04965727","su":"https://scitrials.org/trial/NCT04965727"},{"n":"NCT01932905","t":"Deep rTMS in Central Neuropathic Pain Syndromes","d":"Pain affects up to 30% of the general population. In particular, neuropathic pain (NeP) is caused by lesion or desease affecting peripheral or central somatosensory pathways and affects 7% of the adult population. Despite the availability of evidence based pharmacological and surgical treatment for NeP, about 50% of patients remais symptomatic despite best medical treatment. Some neuropathic pain syndromes are specially refractory. In particular, central NeP is caused by disease or lesion to…","s":"Completed","tr":["Devices","Surgical Procedure","Transcranial Magnetic Stimulation (TMS)"],"o":["Pain Management"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01932905"},{"n":"NCT04292717","t":"Deficit-specific Training in Spinal Disorders","d":"Impairments of walking function after spinal cord lesion due to, for example, inflammation, ischemia or trauma are exceptionally diverse. Depending on the size, location and completeness of the spinal cord lesion, gait dysfunction is often multifactorial, arising from weakness of leg muscles, sensory impairments or spasticity. Locomotor function in humans with spinal cord damage can be improved through training. However, there are no evidence-based guidelines for the treatment of gait…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04292717"},{"n":"NCT07583836","t":"DELAYED VERSUS EARLY SURGICAL DECOMPRESSION FOR TRAUMATIC SPINAL CORD INJURY","d":"To compare the outcome of early versus delayed surgical decompression among patients presenting with traumatic spinal cord injury in a tertiary care hospital.","s":"Recruiting","tr":["Surgical Procedure"],"o":[],"st":[],"co":["Pakistan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07583836","su":"https://scitrials.org/trial/NCT07583836"},{"n":"NCT01983475","t":"Denosumab Administration After Spinal Cord Injury","d":"Sublesional bone loss after acute spinal cord injury (SCI) is sudden, progressive, and dramatic. After depletion of bone mass and the loss of architectural integrity, it may be difficult, if even possible, to restore skeletal mass and strength. Denosumab is a relative new, highly potent anti-resorptive agent that has proven efficacy in postmenopausal osteoporosis to improve bone mass and in solid tumor patients to prevent a skeletal-related event to a greater extent than that with…","s":"Unknown","tr":[],"o":["Bone Strength"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT01983475","su":"https://scitrials.org/trial/NCT01983475"},{"n":"NCT01345019","t":"Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma","d":"The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid in the treatment of bone disease from multiple myeloma.","s":"Completed","tr":["Drugs"],"o":[],"st":["Arizona","Arkansas","California","Connecticut","District of Columbia","Florida","Georgia","Illinois","Indiana","Iowa","Kentucky","Louisiana","Maine","Maryland","Massachusetts","Michigan","Mississippi","Missouri","Montana","Nebraska","Nevada","New Jersey","New York","North Carolina","North Dakota","Oklahoma","Pennsylvania","South Carolina","South Dakota","Tennessee","Texas","Utah","Virginia","Washington","West Virginia","Wisconsin"],"co":["Australia","Austria","Bulgaria","Canada","Czechia","France","Germany","Greece","Hong Kong","Hungary","Ireland","Italy","Japan","Lithuania","Malaysia","New Zealand","Poland","Portugal","Russia","Singapore","Slovakia","South Korea","Spain","Switzerland","Taiwan","Turkey (Türkiye)","Ukraine","United Kingdom","United States"],"lc":309,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01345019"},{"n":"NCT02958904","t":"Depressive Symptoms and Sexual Dysfunction in Traumatic Spinal Cord Injury","d":"Aims: assess the relationship between sexual function and depressive symptoms in individuals with spinal cord injury.","s":"Completed","tr":["Observational"],"o":["Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02958904"},{"n":"NCT06578780","t":"Design and Delivery Preferences for Exercise Intervention in People With Spinal Cord Injury","d":"This research study aims to explore people's understanding of physical activity behavior and perceptions of what a physical activity program should include for supporting initiation and continuous participation. This study will enroll up to 30 adults (18 or over) with spinal cord injury. The study will use a discrete choice experiment (DCE) design that implements both quantitative (development of preference survey) and qualitative approaches (systematic review; test of preference survey).","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06578780","su":"https://scitrials.org/trial/NCT06578780"},{"n":"NCT01516385","t":"Detection of Peripheral Blood Biomarkers in Intermediate Phase Spinal Cord Injury: Correlation With Neurological and Functional Outcomes, and Comparison to Other Central and Peripheral Neurological Conditions.","d":"This research looks for markers in the blood of people with spinal cord injury that may be a sign of injury severity, or serve as a clue to the degree of recovery. Investigators would also like to compare the marker profile of these patient with that of other neurological conditions such as stroke and Guillain-Barre syndrome. Patients participating in this trial will be those accepted to neuro-rehabilitation in Sheba medical center, Israel. They will join the trial at their arrival to the ward…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01516385","su":"https://scitrials.org/trial/NCT01516385"},{"n":"NCT00011336","t":"Determine the Association Between the Level of SCI With Chronic Respiratory Symptoms, Measures of Pulmonary Function, and Respiratory Illness.","d":"This study is using a standardized method to assess respiratory function in SCI in order to determine the association between level of SCI with chronic respiratory symptoms, measures of pulmonary function, and respiratory illness, both cross-sectionally and longitudinally.","s":"Completed","tr":["Observational"],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00011336"},{"n":"NCT05207826","t":"Detrusor Activity Recovery in Acute Traumatic Spinal Cord Injuries","d":"Determining the most appropriate time to evaluate detrusor activity in urodynamic studies for both traumatic and non-traumatic spinal cord injuries","s":"Withdrawn","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05207826"},{"n":"NCT00624806","t":"Developing a Home Telehealth Program to Manage Pressure Ulcers in SCI/D","d":"The Veteran's Health Administration (VHA) is a national leader in using distance technology to monitor patients' self-care via an in-home messaging device with disease management protocols (DMPs). No such DMPs exist for the community dwelling spinal cord injury/disorders (SCI/D) population. Our objective is to develop the tools necessary for implementing a new home telehealth program to manage community-dwelling veterans with SCI/D at high risk of developing pressure ulcers (PrUs).","s":"Completed","tr":["Devices"],"o":[],"st":["Illinois","Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00624806"},{"n":"NCT04465825","t":"Developing Strategies to Optimize the Exercise Response After Tetraplegia.","d":"To identify means to improve exercise performance in participants with tetraplegia.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04465825","su":"https://scitrials.org/trial/NCT04465825"},{"n":"NCT01885962","t":"Development and Feasibility of an Internet Intervention for Adults With Spinal Cord Injury to Prevent Pressure Ulcers","d":"The investigators propose to test the feasibility of iSHIFTup (Internet Skin Health Intervention For Targeted Ulcer Prevention) for adults with spinal cord injury (SCI) to prevent serious pressure ulcers (PrUs) and promote protective health behaviors. This protocol is Phase 2 of a three phase project. In Phase 1, the investigators developed iSHIFTup. In Phase 2, the investigators will test the intervention by partnering with Woodrow Wilson Rehabilitation Center (WWRC) to conduct a randomized…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01885962"},{"n":"NCT04951297","t":"Development and Validation of a Bowel-routine-based Self Report Questionnaire for Sacral Sparing After Spinal Cord Injury","d":"To develop a self-administered tool for assessment of sacral sparing after spinal cord injury (SCI) and to test its validity in individuals with SCI.","s":"Completed","tr":["Observational"],"o":["Bowel Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04951297"},{"n":"NCT03137394","t":"Development of a Model of Shoulder Pain Following Spinal Cord Injury","d":"This study will investigate the progression of musculoskeletal (shoulder muscle flexibility, muscle strength, movement coordination, and rotator cuff health) and psychosocial (fear of movement, pain catastrophizing) impairments for the first year following SCI, starting with inpatient rehabilitation, at 6 months, and at 1 year following SCI. We will use the information obtained from this study information to develop a biopsychosocial prospective surveillance model, a method for early detection…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Mental Health","Motor Function","Pain Management","Quality of Life"],"st":["Maryland","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03137394"},{"n":"NCT07029802","t":"Development of a Novel Evaluation Scale of Mental Body Representation (MBR) for Adults With Spinal Cord Injury","d":"The purpose of this study is twofold: (1) Develop a new evaluation scale for mental body representations (MBR, i.e., body awareness and visuospatial body maps) for adults with spinal cord injury (SCI) with and without neuropathic pain. (2) Assess the psychometric properties of usability, reliability, and validity of the new evaluation scale This is a cross-sectional observational study design. For Aim 1, this study will involve initial item generation for a novel MBR evaluation scale for SCI…","s":"Recruiting","tr":["Observational"],"o":["Pain Management"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07029802","su":"https://scitrials.org/trial/NCT07029802"},{"n":"NCT07289191","t":"Development of a Novel Strategy to Analyze the Effect on Gait Using Transcutaneous Spinal Current Stimulation in Incomplete Spinal Cord Injured Patients","d":"To determine whether the combination of non-invasive spinal cord stimulation together with gait rehabilitation reduces spasticity and facilitates recovery of lower limb motor strength and gait function in patients with incomplete SCI, as well as studying the underlying physiopathological changes following incomplete SCI and its modulation by non-invasive stimulation techniques.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07289191","su":"https://scitrials.org/trial/NCT07289191"},{"n":"NCT07634796","t":"Development of a Pain Rehabilitation Program for Chronic Pain After SCI","d":"Pain rehabilitation programs are essential for optimal treatment of chronic pain and are usually based on the biopsychosocial model. This is, however, not standard care for people with chronic pain after a spinal cord injury (SCI) due to a biomedical focused perspective of SCI and lack of adapted programs. The aims of this feasibility study: 1. Develop a new digital pain rehabilitation program, adapted for the needs of people living with an SCI. 2. To investigate the feasibility and…","s":"Not yet recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07634796","su":"https://scitrials.org/trial/NCT07634796"},{"n":"NCT03985553","t":"Development of a Self- Management Program for Parents With Spinal Cord Injury and Disease","d":"The purpose of this project was to develop and pilot test a self-management program targeted toward individuals with Spinal Cord Injury/Disease (SCI/D) who are current parents or who are considering becoming parents. This Parenting Self-Management Program (PSMP) will allow parents to identify their goals for successful family participation and provide a structure for professionals to use when working with parents with SCI/D to best meet their needs. A draft PSMP was assembled by members of the…","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03985553"},{"n":"NCT00392860","t":"Development of an Ergonomic Wheelchair Pushrim","d":"The purpose of this study is to test the effectiveness of newly designed ergonomic manual wheelchair handrims called the Natural-Fit and PalmRim when compared to a new standard handrim. It is our hope that the new design of the handrims will help reduce upper extremity pain and injury, which is very common among manual wheelchair users. The Natural-Fit handrim was designed to directly address the shortcomings of standard handrims and to improve the standard-round tube handrims which were…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Hand Movement","Pain Management"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00392860"},{"n":"NCT00173784","t":"Development of an Instrumental Activities of Daily Living Scale","d":"This study is to develop an IADL Scale for patients with SCI (IADL-SCI) and examine its psychometric properties in three years.","s":"Unknown","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00173784","su":"https://scitrials.org/trial/NCT00173784"},{"n":"NCT02560506","t":"Development of Low Cost Devices to Increase Access to Treadmill Training","d":"The goals of this Model System Program are to expand upon and advance the findings and outcomes of previous and current Model Systems clinical research, to continue to develop and study the effectiveness of innovative treatment strategies for persons with spinal cord injury (SCI); and to evaluate the benefits of a well-designed, comprehensive, coordinated, interdisciplinary continuum of care that lead to improved outcomes for all persons with SCI. In order to achieve these goals, the following…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02560506"},{"n":"NCT07225582","t":"Development of Optimal Sensory Feedback Strategies to Maximize Function After Tetraplegia","d":"The goal of this clinical trial is to learn more about how stimulating the nerves involved in sensation (either in the limbs or in the brain) can be used to restore sensation in participants who have a spinal cord injury. Participants in this study will have already been enrolled in the \"Reconnecting the Hand and Arm to the Brain (ReHAB)\" study, and received small electrodes in a part of the brain that is involved in sensing touch and pressure in the hand. The ReHAB study participants will also…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Sensory Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07225582","su":"https://scitrials.org/trial/NCT07225582"},{"n":"NCT07663266","t":"Development of Pain Management JITAI Content in Multiple Sclerosis and Spinal Cord Injury","d":"Just-In-Time Adaptive Interventions (JITAIs) offer a framework for delivering personalized behavioral support using time-varying data to optimize the timing and type of intervention content. This project will develop the foundational components of a JITAI tailored to adults with chronic pain and either MS or SCI by drawing on symptom self-management content from existing programs (PainGuide, MyMSToolkit, and MySCIToolkit). Intervention content and delivery parameters will be refined through…","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07663266"},{"n":"NCT07668063","t":"Device for Bladder Control for Men With SCI","d":"Urinary incontinence, bladder frequency, and bladder urgency are significant medical problems for people with overactive bladder (OAB) or neurogenic bladder overactivity (NDO). Affected individuals typically experience reflex bladder contractions in response to bladder filling at low volumes, resulting in urinary incontinence and decreased bladder capacity. This project will advance a new device for administering noninvasive electrical stimulation in order to improve bladder control.","s":"Not yet recruiting","tr":["Devices","Electrical Stimulation"],"o":["Bladder Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07668063"},{"n":"NCT05491837","t":"Device-induced Intermittent Hypoxia in Persons With Incomplete Spinal Cord Injury","d":"Spinal cord injury (SCI) is a devastating disability with physical, social and vocational consequences. Owing to its overwhelming complications, the cost of treatment and rehabilitation increases constantly. Persons with spinal cord injury are always dependent on their families in most of house hold, recreational and activities of daily life. Majority of SCI are incomplete classification C or D as per American spinal injury Association (ASIA). Due to certain spared pathways intrinsic mechanism…","s":"Completed","tr":["Devices","Intermittent Hypoxia","Rehabilitation"],"o":["Arm Movement","Hand Movement","Leg Movement","Motor Function","Plasticity","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05491837"},{"n":"NCT02556125","t":"Diaphragm Pacing After Spinal Cord Injury","d":"Respiratory dysfunction is the leading cause of death in individuals with spinal cord injuries (SCIs). Nearly one quarter of all SCI cases involve injury to the upper spinal cord segments which impairs neural activation of the diaphragm muscle and compromises breathing. Although mechanical ventilation can be life-saving after cervical SCI (C-SCI), it also triggers rapid and profound diaphragm muscle atrophy, thereby complicating (or even preventing) ventilator weaning. Intramuscular diaphragm…","s":"Completed","tr":["Devices","Observational"],"o":["Breathing Function","Motor Function"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02556125"},{"n":"NCT04179799","t":"Diaphragm Pacing in Individuals With Spinal Cord Injuries","d":"This project will evaluate the effects of intramuscular diaphragm stimulation (pacing) and test the hypothesis that diaphragm pacing enhances neuromuscular diaphragm activation and respiratory function in adults with cervical spinal cord injuries (C-SCIs). The investigators will test the hypothesis by recording activity of the diaphragm from intramuscular pacing electrodes and conduct respiratory assessments in adults with intramuscular diaphragm pacing electrodes following acute, traumatic…","s":"Completed","tr":["Devices","Observational"],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04179799"},{"n":"NCT01385384","t":"Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries","d":"Permanent dependency of breathing apparatus due to spinal cord injury is traditionally treated with different types of mechanical ventilation. However, the electric ventilation became a possibility through their most current versions, such as diaphragmatic pacemakers. Diaphragmatic pacemakers rhythmically stimulates the diaphragm to replace the functions of the respiratory center that doesn't works well or is inaccessible. However, this modality has the prerequisite that the phrenic nerve and…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["Brazil"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01385384"},{"n":"NCT02942953","t":"Diaphragmatic Pacer Placement: Anesthetic Management (DP)","d":"The diaphragmatic pacemaker (DP) has proven its utility in replacing mechanical ventilation (MV) in patients with chronic spinal cord injury (SCI) and Amyotrophic Lateral Sclerosis (ALS), by improving the patients quality of life and reducing morbi-mortality and the associated health care costs. The anesthetic management of these patients and the particularities of the surgical procedure represent an anesthetic challenge. The objective of our study is to analyze the management and the…","s":"Completed","tr":["Devices","Observational","Surgical Procedure"],"o":["Breathing Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02942953"},{"n":"NCT06882460","t":"Diet and Exercise Solutions to Postprandial Hypotension","d":"The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.","s":"Recruiting","tr":["Nutrition"],"o":["Blood Pressure"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06882460","su":"https://scitrials.org/trial/NCT06882460"},{"n":"NCT04109586","t":"Diet and Fat Mass After Traumatic Spinal Cord Injury","d":"This is a randomized clinical controlled trial (RCT) to investigate the impact of a personalized nutritional intervention on functional and clinical outcomes the first year after traumatic spinal cord injury. The long term goal is to prevent gain of body fat mass and obesity.","s":"Completed","tr":["Nutrition"],"o":[],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04109586","su":"https://scitrials.org/trial/NCT04109586"},{"n":"NCT02630524","t":"Diet Composition and Cardiometabolic Risk Reduction in Adults With SCI","d":"The purpose of this study is to examine the effectiveness of a low carbohydrate diet on increasing dietary adherence and improving cardiometabolic risk factors among adults with spinal cord injury (SCI). Seventy overweight/obese adults with SCI will be randomized to one of two groups: 1) a reduced carbohydrate diet or 2): a \"standard\" diet (STD). Participants will take part in a 6-month behavioral lifestyle intervention implemented through a novel eHealth platform specially designed for…","s":"Completed","tr":["Devices","Nutrition"],"o":[],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02630524"},{"n":"NCT01025609","t":"Dietary Patterns and Cardiovascular (CVD) Risk in Spinal Cord Injury (SCI) Factors In Individuals With Chronic Spinal Cord Injury","d":"This study will look at dietary patterns in individuals with chronic spinal cord injuries and the relationship between these dietary patterns and cardiovascular disease risk factors. The study is a supplement to the Coronary Artery Risk Development in Young Adults (CARDIA) study. The dietary history from CARDIA will be used. The investigators' primary hypothesis is the following: Greater whole-grain and dietary fiber intake will be favorably associated with adiposity (BMI and WC) and metabolic…","s":"Completed","tr":["Nutrition","Observational"],"o":["Blood Pressure"],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01025609"},{"n":"NCT01393977","t":"Difference Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With Spinal Cord Injury in China","d":"The morbidity of spinal cord injury (SCI) is increasing significantly in China. The methods to treat SCI patients in sequela stage update are poor. Though traditional rehabilitation therapy is the routine method to treat SCI in sequela stage, its effect to improve the neurological disorders of these patients, such as the dysfunction of sense, motor, autologous adjustment of blood pressure control of urination and defecation, perspiration , etc. is unsatisfying. Rehabilitation Therapy can…","s":"Unknown","tr":["Rehabilitation","Stem Cells"],"o":["Motor Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01393977","su":"https://scitrials.org/trial/NCT01393977"},{"n":"NCT01873547","t":"Different Efficacy Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With SCI in China","d":"The morbidity of spinal cord injury (SCI) is increasing year by year significantly in China. The methods to treat SCI patients in sequela stage update are poor. Though traditional rehabilitation therapy is the routine method to treat SCI in sequela stage, aiming to improve the neurological disorders of these patients, such as sensory disturbance, dyskinesia, autologous adjustment of blood pressure, dysfunction of urination, defecation and perspiration , etc. What's a pity, the efficacy of the…","s":"Completed","tr":["Rehabilitation","Stem Cells"],"o":["Bladder Function","Blood Pressure","Bowel Function","Pain Management"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01873547"},{"n":"NCT03254862","t":"Different Stimulation Patterns to Reduce Muscle Fatigue During FES","d":"The main aim of this study is to investigate the effect of patterned distribution stimulation compared to conventional stimulation in reducing muscle fatigue during functional electrical stimulation (FES) following spinal cord injury (SCI).","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03254862"},{"n":"NCT06596187","t":"Differential Assessment of Hypertonia","d":"Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However…","s":"Recruiting","tr":[],"o":["Spasticity"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06596187","su":"https://scitrials.org/trial/NCT06596187"},{"n":"NCT03296592","t":"Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)","d":"Patients who have been diagnosed with Cervical Spondylotic Myelopathy will be asked to undergo an MRI using diffusion basis spectrum imaging (DBSI) technology. The patients will have this MRI preoperatively and at 24 months postop. The investigators believe that with this imaging, biomarkers will be able to be seen to assist in prediction of long term outcomes in patients with spinal cord compression. These patients will be compared to healthy cohorts who will also undergo an MRI using the DBSI…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":[],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03296592"},{"n":"NCT01712698","t":"Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries","d":"Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.","s":"Withdrawn","tr":["Observational"],"o":[],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01712698"},{"n":"NCT07794072","t":"Digital Patient Engagement in Technology-Supported Neurorehabilitation","d":"The goal of this observational study is to investigate digital patient engagement and its psychosocial correlates and potential predictors among adults aged 18-85 years with neurological disorders who are undergoing technology-supported neurorehabilitation using robotic systems for upper-limb training and/or virtual reality-based technologies. Specifically, the study will examine the roles of hope and the quality of the patient-healthcare professional relationship as the potential predictors of…","s":"Not yet recruiting","tr":["Observational","Rehabilitation"],"o":["Arm Movement","Mental Health"],"st":[],"co":["Italy"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07794072"},{"n":"NCT05637775","t":"DiSCIoser: Improving Arm Sensorimotor Functions After Spinal Cord Injury Via Brain-Computer Interface Training","d":"The goal of this clinical trial is to validate the efficacy of a Brain-Computer Interface (BCI)-based intervention for hand motor recovery in subacute cervical spinal cord injured (SCI) patients during rehabilitation. The study will provide evidence for the clinical/neurophysiological efficacy of the BCI intervention as a means to promote cortical sensorimotor plasticity (remote plasticity) and thus maximize recovery of arm functions in subacute cervical SCI. Participants will undergo an…","s":"Completed","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05637775","su":"https://scitrials.org/trial/NCT05637775"},{"n":"NCT05502614","t":"Dorsal Genital Nerve Stimulation for Bladder Management After SCI","d":"Following spinal cord injury signals between the brain and the bladder are disrupted. As a result the bladder often becomes overactive which can lead to the need for frequent trips to the toilet, regular incontinence episodes and a decreased quality-of-life. Neuromodulation is a therapy that aims to target the nerves that become overactive controlling the bladder, stopping the bladder overactivity on demand using an external (non-invasive) nerve stimulation box and sticker electrodes placed on…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05502614","su":"https://scitrials.org/trial/NCT05502614"},{"n":"NCT07619300","t":"Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage","d":"The purpose of this study is to study sensorimotor circuit activity generated in response to temporarily implanted dorsal root ganglion stimulation by recording from muscles of the lower extremities as well as functional outcomes achieved over a 10-day rehabilitation program in an individual with lower motor neuron injury.","s":"Not yet recruiting","tr":["Electrical Stimulation","Rehabilitation"],"o":[],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07619300","su":"https://scitrials.org/trial/NCT07619300"},{"n":"NCT02302157","t":"Dose Escalation Study of AST-OPC1 in Spinal Cord Injury","d":"The purpose of this study is to evaluate the safety of cross sequential escalating doses of AST-OPC1 administered among 5 cohorts at a single time-point between 21 and 42 days post injury, inclusively, to subjects with subacute cervical spinal cord injuries (SCI).","s":"Completed","tr":["Drugs","Safety"],"o":["Arm Movement"],"st":["California","Georgia","Illinois","Indiana","Missouri","Pennsylvania","Wisconsin"],"co":["United States"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02302157"},{"n":"NCT06596291","t":"Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization","d":"This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI), who have persistent incontinence after standard of care therapy and who perform Clear Intermittent Catheterization (CIC) on a regular basis.","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":["California","Michigan","Ohio","Pennsylvania","Texas"],"co":["United States"],"lc":5,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT06596291","su":"https://scitrials.org/trial/NCT06596291"},{"n":"NCT07739992","t":"Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury","d":"This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Leg Movement","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07739992"},{"n":"NCT03602014","t":"Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury","d":"The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males and 100/70 in females. The first aim is to determine the proportion of subject with Spinal Cord Injury (SCI) who have a normotensive response to Droxidopa. The second is to determine the proportion of subject with SCI who express a hypertensive response to Droxidopa. A…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03602014"},{"n":"NCT02340910","t":"Dose-Response Effects of Whole Body Vibration on Spasticity and Walking in SCI","d":"This study will enroll people with SCI who have spasticity and some ability to walk. The goal is to understand if standing on a platform and receiving WBV results in decreased spasticity and improved walking ability. Published article is available (PMID: 29959653)","s":"Completed","tr":[],"o":["Arm Movement","Motor Function","Pain Management","Spasticity","Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02340910"},{"n":"NCT05218447","t":"Dosing of Overground Robotic Gait Training With Functional Outcomes and Neuroplasticity After Spinal Cord Injury","d":"The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation","s":"Active, not recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05218447","su":"https://scitrials.org/trial/NCT05218447"},{"n":"NCT05553353","t":"Dosing rTMS for Depression Post-SCI","d":"Depression is a leading cause of disability worldwide and is more commonly seen in individual's post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals' quality of life and recovery. It has been reported that among Veterans with an SCI, those without depression live longer than those with depression. Thus, depression must be treated appropriately. Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, but…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Mental Health"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05553353","su":"https://scitrials.org/trial/NCT05553353"},{"n":"NCT06853015","t":"Double Dose 4-AP on Functional Recovery After Spinal Cord Injury","d":"The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP). 4-AP will be used twice-daily in combination of Spike-timing-dependent plasticity (STDP) stimulation and STDP stimulation with limb training.","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06853015","su":"https://scitrials.org/trial/NCT06853015"},{"n":"NCT05784285","t":"Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities","d":"Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted. Emerging treatment approaches aimed at improving participation have shifted from focusing only on impaired body functions towards the performance of functional meaningful activities within the youth's natural environment. Investigators' initial results from studies in Quebec show that targeting intervention at the activity/participation…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05784285","su":"https://scitrials.org/trial/NCT05784285"},{"n":"NCT04217577","t":"Dried Plum Supplementation as Treatment for Bone Loss Following Spinal Cord Injury","d":"The purpose of this pilot study is to explore whether dried plum (prunes) added to the diet is effective in reducing or reversing bone loss following spinal cord injury (SCI). The investigators will look for changes in bone mineral density as well as evidence in the blood of markers of bone activity. The first part of the study is to check whether participants with SCI can and will eat the required amount of dried plums (prunes) on a daily basis. The second part of the study is to follow…","s":"Terminated","tr":["Nutrition"],"o":["Bone Strength"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04217577"},{"n":"NCT07473258","t":"DRIV - Health Online for People With Spinal Cord Injury","d":"The goal of this clinical trial is to learn if a 10-week web-based health promotion program (\"DRIV\") can improve healthy lifestyle habits and overall well-being in adults living with long-term spinal cord injury (SCI). The main questions it aims to answer are: Does participating in the online course lead to healthier lifestyle behaviors (for example, more physical activity and a better diet) and improved self-reported health for people with SCI? Are any improvements in health habits or…","s":"Enrolling by invitation","tr":["Nutrition"],"o":["Quality of Life"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07473258","su":"https://scitrials.org/trial/NCT07473258"},{"n":"NCT07467850","t":"Dual Stimulation for Spinal Cord Injury","d":"The goal of this Spinal Cord Injury (SCI) Open-Label Clinical Trial is to test the safety and feasibility of the intervention. The study aims to answer whether implementing this intervention on inpatients at a specialized rehabilitation hospital is possible. All participants will receive the intervention and be asked to report side effects and tolerability. Additionally, injury markers for safety and signal recordings to detect changes will be assessed pre- and post-intervention.","s":"Completed","tr":["Devices","Rehabilitation","Safety","Transcranial Direct Current Stimulation (tDCS)"],"o":["Quality of Life","Spasticity"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07467850"},{"n":"NCT02917590","t":"Dual-task Obstacle Crossing Training in Ambulatory Subjects With Spinal Cord Injury","d":"Is dual-task obstacle crossing training more efficiently than single-task obstacle crossing training on the improvement of walking ability, balance ability, and lower extremity muscle strength in ambulatory subjects with spinal cord injury","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02917590","su":"https://scitrials.org/trial/NCT02917590"},{"n":"NCT07280351","t":"Duraplasty for Acute Traumatic Spinal Cord Injury","d":"The goal of this clinical trial is to learn if a procedure called \"expansile duraplasty\" can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI). The main questions it aims to answer are: * Does expansile duraplasty work to improve recovery in people with acute traumatic SCI? * How safe is the use of expansile duraplasty in people with acute traumatic SCI? Researchers will compare the strength, movement, and overall recovery of participants who receive…","s":"Enrolling by invitation","tr":["Surgical Procedure"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07280351","su":"https://scitrials.org/trial/NCT07280351"},{"n":"NCT04936620","t":"Duroplasty for Injured Cervical Spinal Cord With Uncontrolled Swelling","d":"QUESTION. Does duroplasty improve outcome after spinal cord injury? WHAT DO WE STUDY? We will investigate whether performing a surgical procedure called duroplasty improves outcomes after spinal cord injury. WHY SPINAL CORD INJURY? Spinal cord injury is a devastating condition that causes permanent disability such as paralysis, numbness and loss of bladder and bowel control. Currently, there are no treatments shown to improve outcome after spinal cord injury. WHAT IS DUROPLASTY? Duroplasty is…","s":"Recruiting","tr":["Safety"],"o":[],"st":[],"co":["Austria","Belgium","China","Czechia","Denmark","Finland","Germany","Israel","Slovenia","Spain","Sweden","United Kingdom"],"lc":34,"rlc":29,"cu":"https://clinicaltrials.gov/study/NCT04936620","su":"https://scitrials.org/trial/NCT04936620"},{"n":"NCT04855838","t":"Dysphagia After Anterior Cervical Spine Surgery","d":"The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3 months later. Furthermore, to investigate the effect of a new rehabilitation method for dysphagia among individuals with swallowing dysfunction after ACSS.","s":"Recruiting","tr":["Devices","Nutrition","Rehabilitation","Surgical Procedure"],"o":["Quality of Life"],"st":[],"co":["Sweden"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04855838"},{"n":"NCT02660138","t":"Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1","d":"The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® (AbobotulinumtoxinA) doses (600 units \\[U\\] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult subjects treated for neurogenic detrusor overactivity (NDO) due to spinal cord injury (SCI) or multiple sclerosis (MS).","s":"Terminated","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":["Alabama","Arizona","California","Colorado","Connecticut","Florida","Iowa","Maryland","Michigan","New Jersey","New Mexico","New York","North Carolina","Ohio","Pennsylvania","South Carolina","Tennessee","Texas","Vermont","Virginia","Washington","Wisconsin"],"co":["Canada","Czechia","Italy","Netherlands","Poland","Portugal","Romania","South Korea","Turkey (Türkiye)","United States"],"lc":81,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02660138"},{"n":"NCT02660359","t":"Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 2","d":"The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® doses (600 units \\[U\\] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult subjects treated for neurogenic detrusor overactivity (NDO) due to spinal cord injury (SCI) or multiple sclerosis (MS).","s":"Terminated","tr":["Drugs"],"o":["Bladder Function"],"st":[],"co":["Argentina","Australia","Belgium","Brazil","Chile","Colombia","France","Germany","Israel","Lithuania","Mexico","Peru","Russia","Spain","Ukraine","United Kingdom"],"lc":82,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02660359"},{"n":"NCT00458471","t":"E. Coli for Prevention of Catheter UTI in SCI Patients","d":"The overall goal of this project is to develop a new approach for the prevention of urinary tract infection (UTI) in persons who rely on indwelling catheters for bladder drainage. Veterans with spinal cord injury (SCI) frequently require chronic bladder catheterization. Most individuals with SCI have neurogenic bladders, and the resulting urinary stasis and bladder catheterization predispose them to recurrent UTI.1 The presence of a urinary catheter dramatically increases the risk of UTI, not…","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00458471"},{"n":"NCT04089956","t":"EAdi as a Predictor of Successful Extubation in Patients With Traumatic Cervical Spinal Cord Injury","d":"Esophageal recordings of diaphragm electrical activity (EAdi) made it possible to monitor respiratory drive and the subsequent phrenic nerve conduction and respiratory neuromuscular function continuously. Thus, we designed a \"spontaneous breathing challenge\" test to monitor the change in EAdi after a maximal inspiration. We hypothesized that the absolute change (ΔEAdi) and the percentage changes change (ΔEAdi%) in EAdi after a \"spontaneous breathing challenge\" predict successful extubation in…","s":"Completed","tr":["Observational"],"o":["Breathing Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04089956"},{"n":"NCT06793683","t":"Early BOTOX After Spinal Cord Injury","d":"The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI. Although detrimental cystometric and tissue changes are known to occur, often within 3 months after SCI, the investigators seek to document the time course of these changes and the range of severity of those changes in both those participants that receive prophylactic treatment and those who do not.","s":"Enrolling by invitation","tr":[],"o":["Bladder Function"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06793683","su":"https://scitrials.org/trial/NCT06793683"},{"n":"NCT05255679","t":"Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery","d":"Spinal cord injury (SCI) is a devastating condition that often leads to paralysis and multiple health problems such as muscle wasting, bone loss and spasticity. Despite the paralysis, functional electrical stimulation (FES) on the skin surface muscles may produce muscle contractions. People who have had an SCI for a long time (chronic SCI) already use FES cycling to exercise, and it is known that it can reverse muscle atrophy and has a wide range of health benefits. Furthermore, animal research…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Bone Strength","Mental Health","Motor Function","Pain Management","Plasticity","Spasticity","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05255679"},{"n":"NCT01086930","t":"Early Intensive Hand Rehabilitation After Spinal Cord Injury","d":"Loss of hand function is one of the most devastating consequences of tetraplegia because of the severe impact on activities of daily living (ADL) and the resultant dependency on others. This multi-centre study in 78 participants will measure whether additional hand therapy provided via an electrical stimulator glove and specialised computer workstation improves hand function in people with tetraplegia.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["Australia","New Zealand"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01086930"},{"n":"NCT06452264","t":"Early Intervention for Information Processing Speed Deficits in Acute SCI: A Pilot Study","d":"This study seeks to conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.","s":"Unknown","tr":[],"o":["Mental Health"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06452264","su":"https://scitrials.org/trial/NCT06452264"},{"n":"NCT05506657","t":"Early Intervention to Promote Return to Work for People With Spinal Cord Injury","d":"For many people with spinal cord injury, seeking employment after injury is an important goal. There are services available to help people with disabilities. However, the best ways to coordinate and deliver these services are not yet known. This project will compare two ways of coordinating and delivering services that are designed to help people with spinal cord injury obtain employment.","s":"Unknown","tr":[],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05506657"},{"n":"NCT02334410","t":"Early Intervention to Reduce Bone Loss After Spinal Cord Injury","d":"After a complete spinal cord injury (SCI), the patient becomes wheelchair-dependent, and the associated lack of weight-bearing and inactivity of paralysed muscles can lead to extensive bone loss in the long bones of the legs. It has been documented that the most rapid phase of bone loss is during the first year, but bone loss can continue for a number of years post-injury, leading to an increased risk of fracture in chronic SCI. Through a previous longitudinal study, in which we described rates…","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02334410","su":"https://scitrials.org/trial/NCT02334410"},{"n":"NCT06564714","t":"Early Pharmacological Treatment of Acute Spasticity After Spinal Cord Injury","d":"The objective of this clinical trial is to evaluate if early detection of spasticity and immediate treatment with oral baclofen during acute care prevents problematic spasticity and improves neurofunctional recovery after tSCI. The main questions it aims to answer are : 1. Assess the safety of early baclofen treatment during acute care after SCI. 2. Compare the neurofunctional outcomes between the early baclofen group and the control group up to 6 months after tSCI, in terms of mobility, global…","s":"Not yet recruiting","tr":[],"o":["Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06564714","su":"https://scitrials.org/trial/NCT06564714"},{"n":"NCT07210879","t":"Early Predictors for Neurological Outcome After Traumatic Spinal Cord Injury","d":"This project investigates early predictors of neurological recovery after traumatic spinal cord injury through three main aims: 1. MAP and vasopressors - determine whether continuous monitoring of mean arterial pressure (MAP) and the use of vasopressors in the ICU influence neurological outcome. 2. Pharmacological interventions - evaluate the impact of other medications, particularly opioids in the acute stage, on recovery. 3. Biomarkers - identify diagnostic and prognostic biomarkers…","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07210879","su":"https://scitrials.org/trial/NCT07210879"},{"n":"NCT04034108","t":"Early Surgical Intervention Combined With Weight-supported Walking Training","d":"To determine the efficacy of a novel combinatorial treatment involving early surgical intervention and long-term weight-bearing walking training in spinal cord injury (SCI) patients clinically diagnosed as complete or American Spinal Injury Association Impairment Scale Class A (AIS-A).","s":"Completed","tr":["Surgical Procedure"],"o":["Walking Function"],"st":[],"co":["China"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04034108"},{"n":"NCT02821845","t":"Eccentric Motor Control After SCI","d":"This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at slow to moderate speeds - targeted to rehabilitation eccentric function of the hip and knee.","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Leg Movement","Motor Function","Walking Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02821845"},{"n":"NCT05337982","t":"Eccentric Muscle Training, Stimulation, and Biomarkers in SCI","d":"The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program. This will include checking for certain features called biomarkers by testing participants' spinal fluid and blood and compare these features to individuals without SCI. These features will help investigators determine when to start…","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Ohio"],"co":["Canada","United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05337982","su":"https://scitrials.org/trial/NCT05337982"},{"n":"NCT03698149","t":"ECoG BMI for Motor and Speech Control","d":"Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03698149","su":"https://scitrials.org/trial/NCT03698149"},{"n":"NCT01393444","t":"ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis","d":"The purpose of this research study is to demonstrate that individuals with upper limb paralysis due to spinal cord injury, brachial plexus injury, amyotrophic lateral sclerosis and brain stem stroke can successfully achieve direct brain control of assistive devices using an electrocorticography (ECoG)-based brain computer interface system.","s":"Completed","tr":["Brain Machine Interface (BMI)","Devices"],"o":["Arm Movement"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01393444"},{"n":"NCT02262234","t":"Education Interventions for Self-Management of Pain Post-SCI: A Pilot Study","d":"Chronic pain (pain that is that is present for a long period of time) is very common among people with spinal cord injury (SCI). Unfortunately, chronic pain is very difficult to treat. Many treatments reduce chronic pain only partially. As a result, many people with SCI must find ways of accomplishing daily activities even though they have pain. The purpose of this research study is to determine how well two different kinds of education programs reduce the extent to which chronic pain…","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02262234"},{"n":"NCT04665492","t":"EEG Predictors of Neuropathic Pain in SCI","d":"Spinal cord injury (SCI), induced by damage to the spinal cord, can cause life-altering levels of disability including the development of chronic pain. Central Neuropathic Pain (CNP) typically develops within months after injury in 40-50% of SCI patients, affecting everyday activity, sleep and mood. There is no cure for CNP, it can be very difficult to treat and is often refractory to any pharmacological treatments. In a previous study (study no. 14/WS/1029) the principle investigators showed…","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04665492","su":"https://scitrials.org/trial/NCT04665492"},{"n":"NCT03643770","t":"Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury","d":"Currently, there are a variety of approaches utilized in attempts to improve upper extremity function, including: traditional therapy, neuroprostheses, botulinum toxin injections, or surgical interventions. In addition, regenerative and restorative therapies, such as: epidural stimulation, functional electrical stimulation, and stem cell therapies, show promise in animal models, but are not ready for clinical translation. Subsequently, there is a clear need to develop new strategies that can…","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Functional Electrical Stimulation (FES)","Intermittent Hypoxia","Rehabilitation","Stem Cells","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Motor Function","Plasticity","Regeneration","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03643770"},{"n":"NCT05558657","t":"Effect of Acupressure on Constipation in Community-dwelling Spinal Cord Injury Patients: a Randomized Controlled Trial","d":"Spinal cord injury is a multi-sensory, motor and autonomic dysfunction, caused by various types of acute and chronic central nervous system injuries. And it will affect patient's ability to live normally and return to society. Due to lack of physical activity and psychological and environmental factors, the feces remain in the intestine for too long, and there will be excessive water absorption and lead to dryness and difficulty in excretion and it will be constipation. Chinese medicine…","s":"Completed","tr":["Rehabilitation"],"o":["Bowel Function","Mental Health","Quality of Life","Sensory Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05558657"},{"n":"NCT04625309","t":"Effect of Adaptive Sports After Acquired Physical Disability","d":"This study is a cross-sectional trial which aims to evaluate the effect of practicing a physical activity on different domains of the ICF among individuals with an acquired physical disability. Two different groups of individuals with a spinal cord injury will be enrolled: one composed of subjects who manage to reach the WHO's recommendations regarding physical activity, and the other of subjects who do not.","s":"Completed","tr":["Rehabilitation"],"o":["Pain Management","Quality of Life"],"st":[],"co":["Belgium"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04625309"},{"n":"NCT01046175","t":"Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury","d":"Respiratory complications continue to be one of the leading causes of morbidity and mortality in people with spinal cord injury, especially among cervical and higher thoracic injuries. Both inspiratory and expiratory function are often severely decreased, leading to respiratory complications, such as atelectasis, pneumonia and ventilatory failure. The prevention of these respiratory complications needs to begin immediately after injury. To achieve effective expelling of secretions before they…","s":"Withdrawn","tr":[],"o":["Breathing Function"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01046175"},{"n":"NCT02195895","t":"Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide","d":"The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI). This study will also investigate 1) if alendronate therapy will increase bone strength in people with chronic SCI, 2) the number of participants with adverse events from alendronate, and 3) the effects of alendronate on serum markers of bone metabolism.","s":"Completed","tr":["Drugs","Nutrition"],"o":["Bone Strength","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02195895"},{"n":"NCT07653529","t":"Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury","d":"This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.","s":"Not yet recruiting","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Trunk Control","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07653529"},{"n":"NCT07678437","t":"Effect of Blood Flow-restricted Exercise Frequency on Strength Recovery Following Incomplete SCI","d":"The goal of this clinical trial is to determine the effect of treatment frequency on the physical recovery of adults with incomplete spinal cord injury. The treatment will last for eight weeks and will occur either either two or three times weekly. The main research questions are: 1. How do changes in muscle strength compare between participants who receive eight weeks of blood flow-restricted exercise two times vs. three times weekly? 2. How do changes in the level of independence performing a…","s":"Enrolling by invitation","tr":[],"o":["Motor Function","Quality of Life"],"st":["Nebraska"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07678437"},{"n":"NCT01682603","t":"Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients","d":"To investigate the clinical effect of detrusor botulinum toxin A (BoNT-A) injection on neurogenic detrusor overactivity (NDO) and renal function and to compare the difference of expressions of sensory receptors and nerve growth factor (NGF) in the bladder wall of patients respond and not respond to BoNT-A injections in chronic spinal cord injured (SCI) patients.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01682603"},{"n":"NCT01222468","t":"Effect of Cannabinoids on Spasticity and Neuropathic Pain in Spinal Cord Injured Persons","d":"This study is being conducted to study the effect of nabilone (a synthetic cannabinoid)on spasticity in spinal cord injured persons.The study will be a phase 2, randomized, placebo-controlled crossover study. Each eligible subject will participate for 26 weeks.Subjects will be randomized to receive either nabilone or placebo during phase 1 of the study. Study drug will be titrated up from 0.5mg daily to a maximum of 3.0 mg daily over the first 11-week phase. Following a 4-week washout period…","s":"Completed","tr":["Drugs"],"o":["Pain Management","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01222468"},{"n":"NCT07633249","t":"Effect of Core Stability Training on Trunk Control and Sitting Balance in Patients With Paraplegia","d":"This study aims to investigate the effect of core stability training on trunk control and sitting balance in patients with paraplegia resulting from incomplete spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Trunk Control"],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07633249"},{"n":"NCT01079169","t":"Effect of Cranberry Capsules on Urinary Infection Rates in Spinal Cord Injured Patients During Post Acute Rehabilitation","d":"The purpose of this study is to establish whether cranberry capsules reduce rates of urinary tract infections during initial rehabilitation immediately after spinal cord injury.","s":"Terminated","tr":["Rehabilitation"],"o":["Bladder Function"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01079169"},{"n":"NCT06214546","t":"Effect of Different Support Systems on Gait","d":"Body weight support systems are commonly used for gait training. A new breed of devices for gait training are soft exosuits. To optimize rehabilitation outcomes, it is important to gain deeper insight in the effect of these support systems on gait. The aim of this study is to investigate the effect of a body weight support system and soft exosuit on dynamic balance and knee and hip kinematics during gait in people with incomplete spinal cord injury.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Trunk Control","Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06214546"},{"n":"NCT05262816","t":"Effect of Electroacupuncture at Different Acupoints on Bladder Function After Spinal Cord Injury","d":"Neurogenic bladder after spinal cord injury can be divided into detrusor hyperreflexia and detrusor non reflexia. Acupuncture is recognized as a safe and effective treatment. The most commonly used acupoints are Guanyuan, Zhongji and Sanyinjiao. The purpose of this study is to clarify the therapeutic effects of different acupoints on different types of bladder. Main process: routine urodynamic examination was performed first, and then electroacupuncture was given to Guanyuan, Zhongji and…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05262816","su":"https://scitrials.org/trial/NCT05262816"},{"n":"NCT02265042","t":"Effect of Electrostimulation on Denervated Muscles in Individuals With Spinal Cord Injury","d":"The aim of the study is to investigate whether there is an effect of electrical stimulation on the denervated gluteus muscle (buttocks) in individuals with chronic spinal cord injury. The expected outcome is an increase in muscle volume and a better pressure distribution during sitting. The stimulation of the gluteus muscle is performed daily for 35 minutes over a period of six months. The muscle volume and the pressure distribution are measured before stimulation, three months after having…","s":"Completed","tr":["Electrical Stimulation"],"o":["Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02265042"},{"n":"NCT00223912","t":"Effect of Exercise on Blood Coagulation in Persons With Chronic Spinal Cord Injury","d":"The purpose of this study is to determine if exercise affects the clotting of blood (hemostasis). The effect of exercise on hemostasis will be determined in persons with spinal cord injury, a population reported to have an increased prevalence of cardiovascular disease (CVD). It is expected that this study will increase our understanding of CVD in persons with SCI, and it will eventually help reduce the occurrence of premature heart disease.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00223912"},{"n":"NCT00678548","t":"Effect of Guided Imagery on Patients With Chronic Pain Related to Spinal Cord Injury","d":"Chronic pain after spinal cord injury in or below the level of injury is a common problem and can be severe. The purpose of our study is to investigate the effect of pleasant guided imagery on spinal cord injured patients with chronic pain in or below the level of injury.","s":"Withdrawn","tr":[],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00678548"},{"n":"NCT02488824","t":"Effect of Heat Exposure on Cognition in Persons With Tetraplegia","d":"The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (\\<95 F) have been documented in this population after exposure to even mild environmental temperatures. However, no work to date has addressed the effect of subnormal Tcore on cognitive performance in persons with tetraplegia despite studies with able-bodied (AB) individuals that have documented progressive decline in various aspects of cognitive…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02488824"},{"n":"NCT07263581","t":"Effect of Hybrid Functional Electrical Stimulation and Augmented Reality-Based Gait Training on Gait Parameters Among Incomplete Spinal Cord Injury Patients","d":"The goal of this clinical trial is to determine whether combining Functional Electrical Stimulation (FES) with Augmented Reality (AR)-based gait training can improve walking ability in individuals with incomplete spinal cord injury (SCI). The study aims to identify the most effective rehabilitation approach for enhancing gait performance and functional independence among these patients. In this study, participants will include: * Adults aged 18-45 years * Diagnosed with incomplete spinal cord…","s":"Recruiting","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07263581","su":"https://scitrials.org/trial/NCT07263581"},{"n":"NCT05536076","t":"Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury","d":"It is estimated that 1,275,000 people in the United States alone live with spinal cord injury, including around 100,000 Veterans with spinal cord injury, making the V.A. the largest integrated health care system in the world for spinal cord injuries injury care. New therapies are needed to prevent the morbidities and mortalities associated with the high prevalence of respiratory disorders in Veterans with spinal cord injury. The current research project and future studies would set the base for…","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05536076","su":"https://scitrials.org/trial/NCT05536076"},{"n":"NCT01831414","t":"Effect of Immersion Level on Respiratory Function of Spinal Cord Injury Patients During Balneotherapy","d":"Balneotherapy is a physiotherapy technique which allows patients to work out in a weightless environment and which is often used in patients with spinal cord injury. In normal subjects, water immersion generates a reduction in lung volumes. The effects of water immersion on the respiratory function of spinal cord injury patient (who are liable to present a respiratory failure secondary to paralysis) are not well known. They could be deleterious (by majoring respiratory failure)or beneficial (by…","s":"Completed","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01831414"},{"n":"NCT01386762","t":"Effect of Intense Multi-modal Training on Bone Health and Quality of Life in Persons With Spinal Cord Injury","d":"Bone loss is a common secondary complication of spinal cord injury (SCI), and treatments used to reverse this condition have equivocal effectiveness. The aim of this study is to determine the effect of intense multi-modal training on bone health, body fat, and quality of life in persons with SCI. Participants will complete 6 months of training during which various measures will be obtained at 0, 3, and 6 months. Control subjects are also being recruited to complete testing but not participate…","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01386762","su":"https://scitrials.org/trial/NCT01386762"},{"n":"NCT01153022","t":"Effect of Joint Mobilization on Alpha Motoneuron Reflex Excitability","d":"Objective: To determine the effect of ankle joint mobilization on the alpha motoneuron reflex excitability of the soleus muscle in people with spasticity. Subjects and Methods: A controlled clinical trial with crossover design and simple masking was conducted in 24 randomized subjects to initiate the control or experimental group. Traction and rhythmic oscillation were applied for five minutes to the ankle joint. Alpha motoneuron reflex excitability was assessed by measuring H wave amplitude…","s":"Completed","tr":[],"o":["Spasticity"],"st":[],"co":["Colombia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01153022"},{"n":"NCT00871455","t":"Effect of Low-Dose Baclofen Administration on the GH-IGF1 Axis Study","d":"Insulin-like growth factor I (IGF-I) is used as a measure of the body's ability to produce growth hormone. Growth hormone is important for muscle tissue as well as many other tissues in the body. Growth hormone (GH) and IGF-I have been shown to be reduced in many persons with SCI. Baclofen is a FDA approved drug that is used to treat spasticity. Persons receiving long-term baclofen therapy have been demonstrated to have increased growth hormone and IGF-I levels. IGF-I levels will be determined…","s":"Completed","tr":["Drugs"],"o":["Spasticity"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00871455"},{"n":"NCT06169969","t":"Effect Of Magnetic Therapy In Bladder Dysfunction And Quality Of Life In Paraplegic Patients","d":"Each study subject will undergo baseline urodynamic testing (UDS) at the beginning of the study to confirm the diagnosis of a neurogenic bladder with DSD and establish baseline bladder functions. The study will be divided into two phases: a Treatment phase (16 weeks) and a Follow-up phase (6 weeks). During the treatment phase, each subject will undergo once/week magnetic spinal cord stimulation (MSCS) at 1Hz (low) frequency (40-60% intensity) over the lumbar spine. Once each subject entered the…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Stem Cells"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06169969"},{"n":"NCT07164846","t":"Effect of Neuro20 Functional Electrical Stimulation Suit on Autonomic Function, Muscle Performance, and Gait","d":"This research aims to understand the effect of the Neuro20 Functional Electrical Stimulation Suit on autonomic nervous system function, muscle performance, and gait after amputation or neurologic injury.","s":"Recruiting","tr":["Electrical Stimulation","Exoskeleton"],"o":[],"st":["Florida"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07164846","su":"https://scitrials.org/trial/NCT07164846"},{"n":"NCT00826228","t":"Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)","d":"Individuals with spinal cord injury sustain significant loss of bone mass in their lower extremities (20-40% or more). This study evaluates the ability of PTH and weight-bearing, two interventions that build bone, to increase bone mass in this population.","s":"Completed","tr":["Drugs"],"o":["Bone Strength"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00826228"},{"n":"NCT04384172","t":"Effect of Peripheral Neuromodulation on Vaginal Blood Flow","d":"The researchers want to see if nerve stimulation interventions cause a change in vaginal blood flow. This intervention was performed in women who have neurogenic (spinal cord injury) or non-neurogenic sexual dysfunction and healthy women.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04384172"},{"n":"NCT03748290","t":"Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI","d":"Central neuropathic pain (CNP) is defined as chronic pain due to injury or disease in the central nervous system. This pain is most common among people with a spinal cord injuries (SCI), with a prevalence of about 50%. The central pain usually develops within a few months of spinal cord injury - and this period is significance in terms of this research work. This pain is one of the most complex and challenging pain syndromes. One of the reasons for this stems from its adherence to most…","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["Israel"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03748290","su":"https://scitrials.org/trial/NCT03748290"},{"n":"NCT00387673","t":"Effect of Prolonged Electrical Stimulation on Neural Plasticity in Spinal Cord Injury","d":"Electrical stimulation (pulses of electricity applied over the skin of your wrist) and activity-based hand exercise have been shown to improve motor skill and strength in individuals with stroke and have recently been shown to also have an effect on individuals with spinal cord injury. Therefore, the purpose of this research study is to investigate whether electrical stimulation alone or electrical stimulation followed by activity-based training produces gains in pinch strength (how hard you…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Plasticity"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00387673"},{"n":"NCT06547606","t":"Effect of Resistive Inspiratory Muscle Training Optimizing Lung Function in Spinal Cord Injury","d":"The goal of this clinical trial is to evaluate the effectiveness of resistive inspiratory muscle training (RIMT) in optimizing lung function in individuals with spinal cord injury (SCI). It will also learn about the safety and impact of RIMT on health-related quality of life in this population. The main questions it aims to answer are: Does RIMT improve respiratory function in individuals with SCI? What impact does RIMT have on the health-related quality of life of participants? What are the…","s":"Unknown","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06547606","su":"https://scitrials.org/trial/NCT06547606"},{"n":"NCT04271904","t":"Effect of Sham Anti-inflammatory Diet on Inflammation After Spinal Cord Injury","d":"This pilot study will evaluate the effects of a placebo anti-inflammatory diet in individuals with spinal cord injury. It is being performed to ensure that the placebo diet does not induce reductions in inflammation and also adequately conceals group allocation.","s":"Completed","tr":["Nutrition"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04271904"},{"n":"NCT04879602","t":"Effect of Suctioning by Bronchoscope on Postoperative Pulmonary Complications Among Patients With SCI in the PACU","d":"Respiratory failure and dyspnea are common in spinal cord injury (SCI), and in acute situations, any spinal cord lesion above T11 can cause abnormal respiratory function and impair the airway clearance. Although surgical decompression is one of the key early neuroprotective therapies, surgery and general anesthesia disrupt many aspects of respiratory function and may cause a series of postoperative pulmonary complications. Endotracheal suction is important to reduce the risk of lung…","s":"Unknown","tr":[],"o":["Breathing Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04879602","su":"https://scitrials.org/trial/NCT04879602"},{"n":"NCT01067391","t":"Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males","d":"To address the effect of tadalafil (Cialis) on the cardiovascular system of men with complete spinal cord injury at T-6 and above. The hypothesis is that tadalafil will cause significant hypotension in people with tetraplegia.","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01067391"},{"n":"NCT01225055","t":"Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury","d":"Spinal cord injury (SCI) results in marked acute loss of bone. This study evaluates the effect of teriparatide (PTH) and the use of vibration as a form of mechanical stimulation on bone mass.","s":"Completed","tr":["Devices","Drugs"],"o":["Bone Strength"],"st":["Illinois"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01225055"},{"n":"NCT06627881","t":"Effect of Three Training Programs on the Cardiovascular Condition of Individuals with Spinal Cord Injury","d":"Objective: Describe the effect of different aerobic training programs on the autonomic nervous system (ANS), cardiovascular condition, body composition, metabolic profile, movement and functional independence in patients with spinal cord injury (SCI). Design: Randomized clinical trial Participants: Individuals in the chronic phase of SCI. Interventions: Three training programs: continuous aerobic in kayak, aerobic resistance circuit, and high-intensity interval with rope. The main measures to…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Mexico"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06627881","su":"https://scitrials.org/trial/NCT06627881"},{"n":"NCT07050069","t":"Effect of Threshold Pressure-Loaded RMT + tTBS on Respiratory Function in SCI Patients","d":"The purpose of this clinical trial is to understand whether threshold pressure load respiratory muscle training combined with iTBS can effectively improve the respiratory function of SCI patients. The main questions it aims to answer are: * The impact of threshold pressure load respiratory muscle training on the respiratory function of SCI patients. * The impact of iTBS treatment at the cortical projection point of the diaphragm on the respiratory function of SCI patients. * Whether the…","s":"Recruiting","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07050069","su":"https://scitrials.org/trial/NCT07050069"},{"n":"NCT07293780","t":"Effect of TMS on Neuropathic Pain for Patients With Sci","d":"The aim of this study is to evaluate the efficacy of rTMS targeting the anterior cingulate cortex, another stimulation site that may be effective in the treatment of neuropathic pain, and to compare it with motor cortex stimulation.","s":"Recruiting","tr":["Transcranial Magnetic Stimulation (TMS)"],"o":["Pain Management"],"st":[],"co":["Turkey (Türkiye)"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07293780","su":"https://scitrials.org/trial/NCT07293780"},{"n":"NCT07007884","t":"Effect of Transauricular Vagal Stimulation on Cardiac Function After Spinal Cord Injury","d":"The aim of this study is to investigate the effect of transauricular vagal nerve stimulation (taVNS) on cardiac autonomic functions in patients with spinal cord injury (SCI).","s":"Recruiting","tr":["Electrical Stimulation"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07007884","su":"https://scitrials.org/trial/NCT07007884"},{"n":"NCT06596174","t":"Effect of tSCS on Ankle Movement Training in Individuals With SCI","d":"This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI). While epidural spinal cord stimulation (eSCS) has shown functional benefits, its application is limited by the side effects associated with implanted electrodes. tSCS, which shares a similar mechanism but does not require surgery, has yet to be extensively studied in large human…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06596174","su":"https://scitrials.org/trial/NCT06596174"},{"n":"NCT04390087","t":"Effect of Upper-body Rowing on Cardiometabolic Risk in Spinal Cord Injured Wheelchair Users","d":"This randomized controlled trial will determine the effects of 12-weeks of wheelchair user-modified upper-body rowing on both traditional cardiometabolic risk factors in SCI manual wheelchair users.","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Pain Management","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04390087"},{"n":"NCT06978205","t":"Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury","d":"Trial Objectives: This clinical trial aims to explore whether ultrasound - guided urethral balloon dilation can effectively improve the micturition function of patients with urinary retention after spinal cord injury, and to evaluate the safety of this treatment method. The main questions it attempts to answer are: Can ultrasound - guided urethral balloon dilation reduce the residual urine volume and improve the quality of life of patients with urinary retention after spinal cord injury? Trial…","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06978205","su":"https://scitrials.org/trial/NCT06978205"},{"n":"NCT02998021","t":"Effect of Vibration Exercise on Upper Limb Strength, Function, and Pain","d":"The primary purpose of this study is to explore the benefits of vibration dumbbell resistance training over standard dumbbell resistance training for improving upper limb strength, function and pain among manual wheelchair users with paraplegia.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Motor Function","Pain Management"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02998021"},{"n":"NCT00886145","t":"Effect of Vibration Therapy on Bone in Persons With Sub-acute Spinal Cord Injury","d":"The purpose of this research study is to determine the effect of mechanical vibrations on bones of persons with spinal cord injury.","s":"Completed","tr":["Devices"],"o":["Bone Strength"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00886145"},{"n":"NCT04383873","t":"Effectiveness Analysis of Armeo Spring Device as a Rehabilitation Treatment in Spinal Cord Injured Patients","d":"Loss of motor function is a consequence after a spinal cord injury (SCI). The incidence of SCI varies greatly from 12.1 to 57.8 cases per million depending on the country. More than 50% of people with SCI have impaired upper limb (UL) function, experiencing limitations in performing functional tasks. In this context, one of the rehabilitation objectives is to achieve the maximum level of independence in the patient in the performance of activities of daily living (ADL). Within the clinical…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Hand Movement","Mental Health","Motor Function","Quality of Life"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04383873"},{"n":"NCT05187650","t":"Effectiveness of a Powered Exoskeleton Combined With FES for Patients With Chronic SCI: a RCT","d":"While there are a number of prospective studies evaluating powered exoskeletons in SCI patients, to date, not a single well-designed, randomized clinical trial has been published. However, there is evidence for beneficial effects of over-ground exoskeleton therapy on walking function post-intervention from a meta-analysis on non-randomized, uncontrolled studies. Functional electrical stimulation (FES), on the other hand, is a common and established method for the rehabilitation of persons with…","s":"Recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05187650","su":"https://scitrials.org/trial/NCT05187650"},{"n":"NCT01147185","t":"Effectiveness of Automated Locomotor Training in Patients With Acute Incomplete Spinal Cord Injury: A Multicenter Trial","d":"The purpose of this study is to determine whether longer locomotor training results in a mor favorable outcome in patients with incomplete spinal cord injury.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Germany","Spain","Switzerland"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01147185"},{"n":"NCT00256672","t":"Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury","d":"The purpose of this study is to determine whether full-time high dose prophylactic bracing (23 hours or more per day) is more effective than low dose bracing (12 hours or less per day) in preventing or delaying spinal curve progression in children with scoliosis after spinal cord injury.","s":"Unknown","tr":["Devices"],"o":["Bone Strength"],"st":["California","Illinois","Pennsylvania"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00256672","su":"https://scitrials.org/trial/NCT00256672"},{"n":"NCT00488969","t":"Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury","d":"We would like to learn if a medicine called \"modified-release morphine sulfate\" (Avinza) helps reduce Spinal Cord Injury (SCI)-related pain that has lasted a long time. \"Modified-release\" means that the medicine in the capsules is slowly released to the body, instead of being released all at once. Avinza is approved by the Food and Drug Administration for the treatment of pain, but we do not know how effective Avinza is in reducing SCI-related pain.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00488969"},{"n":"NCT03709797","t":"Effectiveness of Dry Needling as a Treatment of Shoulder Myofascial Pain Syndrome in Spinal Cord Injury Patients","d":"Shoulder pain in people with spinal cord injury is one of the most prevalent in acute and chronic patients because of weakness in shoulder periarticular muscles, and also because of overuse of these part of the body in assistive devices. This study aims to evidence if dry needling (a physiotherapy technique) is also useful in patients with spinal cord injury, and how long it could hold out without or less pain.","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03709797","su":"https://scitrials.org/trial/NCT03709797"},{"n":"NCT03048357","t":"Effectiveness of Freedom Bed Compared to Manual Turning in Prevention of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and/or Spinal Cord Injury.","d":"Observational comparison on Incidence of Pressure Injury between the Freedom Bed Automated Continuous lateral Rotation Therapy System and Manual Caregiver Re-positioning every 2 hours on a standard Hospital Bed.","s":"Unknown","tr":["Devices"],"o":["Pressure Sores"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03048357","su":"https://scitrials.org/trial/NCT03048357"},{"n":"NCT03808363","t":"Effectiveness of High Intensity Interval Training (HIIT) on Improving Cardiometabolic Health After SCI","d":"Testing the efficacy of high intensity interval training (HIIT), as compared to current research supporting moderate intensity continuous training (MICT), as a means to improve cardiometabolic health after spinal cord injury.","s":"Completed","tr":[],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03808363"},{"n":"NCT03533400","t":"Effectiveness of Jamboxx Respiratory Therapy Device: Study 1","d":"The Effectiveness of the Jamboxx Respiratory Therapy Device in Treatment of Patients with Decreased Respiratory Function is a proposal for investigation of the application of gaming to improving respiratory health. The Jamboxx device combines gaming with traditional incentive spirometry to provide users with a fun experience to keep them engaged in their respiratory therapy routine. The device allows users to play a series of mini-games that walk them through their routines. The Jamboxx also…","s":"Withdrawn","tr":["Devices"],"o":["Breathing Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03533400"},{"n":"NCT04790149","t":"Effectiveness of NEUROM and tDCS for Motor Recovery in Chronic Paraplegia","d":"Traumatic Spinal Cord Injury (TSCI) is a catastrophic, unexpected, and devastating event that can occur along the spinal column (cervical, thoracic, and lumbar). Traditional views describe the spinal cord as a protected bundle of nerves connecting the brain to the body. TSCI often results in life-threatening conditions including varying degrees of motor paralysis, sensory loss, and impairment of bowel, bladder, sexual, and other physiologic functions. In this study, the investigators propose a…","s":"Completed","tr":["Rehabilitation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Bladder Function","Bowel Function","Leg Movement","Motor Function","Plasticity","Sensory Function"],"st":[],"co":["Lebanon"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04790149"},{"n":"NCT01889940","t":"Effectiveness of Psycho-emotional Support in Acute Spinal Cord Injury. ESPELMA Project","d":"The purposes of the ESPELMA project are twofold: 1) To increase acute spinal cord injury patients' satisfaction with treatment while hospitalization and 2) To increase mastery among rehabilitation professionals with regard to the clinical management of patients' psychological distress. For these purposes, a tailored training for professionals will be designed and offered. It is hypothesized that building capacity among professionals will serve to better management of patients' distress and a…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01889940"},{"n":"NCT06089915","t":"Effectiveness of Robot-assisted Upper-limb Exercise in Cervical SCI","d":"The aim of the project is to test the effectiveness of robot-assisted upper-limb exercise in persons after cervical spinal cord injury. In a randomised controlled two-arm trial, the effect of adding two types of robot-assisted upper-limb exercise to standard occupational therapy will be tested. Three primary and two secondary outcomes will be assessed using well-established measures.","s":"Recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Slovenia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06089915","su":"https://scitrials.org/trial/NCT06089915"},{"n":"NCT04457206","t":"Effectiveness of the Collaborative Community Clinic for Persons With Spinal Cord Injury and Disease","d":"The investigator is evaluating data stored on the Collaborative Community Clinic data repository (IRB #201811032). Researchers seek to evaluate the effectiveness of the Collaborative Community Clinic (CCC), an occupational therapy student experiential learning clinic for uninsured or under-insured people with spinal cord injury and disease (SCI/D), using participants' initial and follow-up assessment batteries.","s":"Active, not recruiting","tr":["Observational","Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04457206"},{"n":"NCT03118960","t":"Effectiveness of the Freedom Bed as Compared to Alternating Pressure Mattress in Treatment of Pressure Injuries in Persons With Limited Mobility Due to Traumatic Brain Injury and /or Spinal Cord Injury","d":"This non-randomized clinical study will compare pressure injuries and the change in pressure injuries for subjects who are placed on the Freedom Bed compared to those placed on a standard Group II Low Air Loss/Alternating Pressure Mattress in the Ventilator Unit at Northeast Center for Rehabilitation and Brain Injury. Additionally, the incidence of pneumonia, urinary tract infections, circulatory performance, sleep deprivation and caregiver self-perception on performance will be monitored and…","s":"Unknown","tr":["Devices"],"o":["Pressure Sores"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03118960","su":"https://scitrials.org/trial/NCT03118960"},{"n":"NCT00150683","t":"Effectiveness of Vibration and Standing Versus Standing Alone for the Treatment of Osteoporosis for People With Spinal Cord Injury.","d":"The purpose of this study is to find out if standing and/or standing with vibration works for the treatment of osteoporosis for people with a spinal cord injury.","s":"Completed","tr":["Devices"],"o":["Bone Strength","Quality of Life","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00150683"},{"n":"NCT05142943","t":"Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function in People With Incomplete Spinal Cord Injury.","d":"Previous studies have shown that the neuroplasticity of the residual corticospinal fibers, the motor cortex and the spinal neurons plays an important role in the spontaneous functional recovery of people with neurological or musculoskeletal pathology. However, it is also possible to stimulate the neuroplasticity mechanisms of these structures through techniques aimed at rehabilitating different deficits (for example, motor function or sensitivity). In general, intervention programs are usually…","s":"Recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05142943","su":"https://scitrials.org/trial/NCT05142943"},{"n":"NCT04809987","t":"Effectiveness of Virtual Gait System Intervention in Motor Function in People With Incomplete Spinal Cord Injury.","d":"Roughly 60% of people with Spinal Cord Injury (SCI) have an incomplete one, with a strength, sensibility, and muscle tone alteration. Moreover, this condition involves a high impact on the psychological and socioeconomic levels. After an incomplete SCI, spontaneous functional recovery occurs. This recovery is strong associated with injury and person characteristics, and with corticospinal fibers, motor cortex, and spinal neurons neuroplasticity. However, also it is possible to stimulate…","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04809987","su":"https://scitrials.org/trial/NCT04809987"},{"n":"NCT05447676","t":"Effects of 4-AP on Functional SCI Recovery","d":"The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP). 4-AP will be used in combination of Spike-timing-dependent plasticity (STDP) stimulation and STDP stimulation with limb training.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Bladder Function","Bowel Function","Leg Movement","Motor Function","Plasticity","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05447676"},{"n":"NCT04000919","t":"Effects of 5HTP and LDOPA on CNS Excitability After SCI","d":"This study will examine whether supplementation with the serotonin and dopamine precursors, 5HTP and L-DOPA can alter central nervous system excitability and improve motor function after incomplete and complete spinal cord injuries.","s":"Suspended","tr":["Drugs","Nutrition"],"o":["Motor Function","Plasticity","Spasticity"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04000919"},{"n":"NCT04520178","t":"Effects of 5HTP on the Injured Human Spinal Cord","d":"This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Kentucky"],"co":["Canada","United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04520178","su":"https://scitrials.org/trial/NCT04520178"},{"n":"NCT03837834","t":"Effects of 6 Weeks High-intensity Interval Training Among Spinal Cord Injury","d":"The training consists of 6 weeks of functional electrical stimulation leg cycling exercise (FES-LCE) program. The training program comprises of 2 visits per week. Each visit consists of FES-LCE for 45 minutes. Throughout the 6 weeks program, there will be testing/assessment sessions on week 1, week 3 and week 6. The FES will be applied via surface electrodes and the stimulation intensity based on the participant's tolerance level.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":[],"st":[],"co":["Malaysia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03837834"},{"n":"NCT02672670","t":"Effects of a Coping-oriented Supportive Programme (COSP) for People With Spinal Cord Injury During Inpatient Rehabilitation","d":"The aim of this proposed PhD study is to test the effectiveness of a newly developed coping-oriented supportive programme (COSP) for Chinese people with SCI during their early period of inpatient rehabilitation in Xi'an, China. The objectives of this study are to develop and validate the COSP in the inpatient rehabilitation hospitals; and to evaluate the effectiveness of this COSP for the SCI inpatients in two rehabilitation wards on their coping abilities, self-efficacy, mood status, and life…","s":"Unknown","tr":[],"o":["Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02672670","su":"https://scitrials.org/trial/NCT02672670"},{"n":"NCT06444672","t":"Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury","d":"Background: The scarcity of resources for spinal cord injury (SCI) rehabilitation constitutes a significant obstacle, particularly in war-torn regions experiencing a rise in such injuries. Implementing a home-based rehabilitative program (HBRP) tailored to patients' environmental, social, and financial contexts is crucial in mitigating this challenge. The authors investigated the effects of a 24-month HBRP on anthropometric measurements, muscular strength, sensory and motor function, and…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Iraq"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06444672"},{"n":"NCT06891989","t":"Effects of a Mobile App-Based Mindfulness Intervention in Persons With Spinal Cord Injury and Chronic Pain","d":"The purpose of this study is to evaluate the efficacy of a 6-week app-guided MM intervention compared to a 6-week app-guided health education AC condition on pain intensity, pain interference, depression, and anxiety.","s":"Not yet recruiting","tr":[],"o":["Mental Health","Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06891989","su":"https://scitrials.org/trial/NCT06891989"},{"n":"NCT07732868","t":"Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury","d":"Spinal cord injury (SCI) is a highly debilitating pathology, associated with the loss of sensorimotor functions, autonomy and quality of life. Although there is currently no cure, brain-machine interfaces (BMI) have been used as a method of SCI rehabilitation. BMIs use neurophysiological signals recorded by techniques such as electroencephalography (EEG) to produce a response in a device. Recently, BMIs have achieved clinically relevant improvements in several neuropathologies. However, the…","s":"Enrolling by invitation","tr":["Brain Machine Interface (BMI)","Devices","Exoskeleton","Rehabilitation"],"o":["Pain Management","Quality of Life","Sensory Function","Walking Function"],"st":[],"co":["Portugal"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07732868"},{"n":"NCT04823078","t":"Effects of Activity Based Therapy on Upper Limb Strength and Transfer in Spinal Cord Injury Patients","d":"In our society spinal cord injury is a major problem.activity based therapy and conventional therapy has a potentional to improve upper limb strength and transfer in tetraplegic patients. The aim of this study is to determine the effects of activity based therapy versus conventional therapy to improve the upper limb strength and transfer in spinal cord injury. The study design used was randomized clinical trial. The study was conducted at the paraplegic center Peshawar in 6 weeks after the…","s":"Completed","tr":[],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04823078"},{"n":"NCT00013312","t":"Effects of Acute SCI on Colonic Motility & Tone","d":"This study will compare individuals with acute SCI to control patients in order to: 1. Determine if there are changes in colonic tone and sensation after SCI by comparing the fasting responses to the postprandial responses; 2. Determine if there are changes in colonic phasic motility after SCI by comparing the fasting responses to the postprandial responses; 3. Determine if colonic motor and sensory function after SCI change over time by repeating these studies six month later in SCI and…","s":"Completed","tr":[],"o":["Sensory Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00013312"},{"n":"NCT03340792","t":"Effects of Ambulation Training Utilizing an Exoskeleton Robot on Subjects With Spinal Cord Injury","d":"The present study aims to investigate the effects of ReWalk exoskeleton robot training on various physiological and psychological parameters among subjects with spinal cord injury, including body composition and bone mineral mass, balance ability, bowel and bladder symptoms, severity of pain, psychological well-being, and quality of life. Ten patients with paraplegia caused by spinal cord injury will be recruited from the out-patient clinic of Department of Physical Medicine and Rehabilitation…","s":"Unknown","tr":["Exoskeleton"],"o":["Bone Strength"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03340792","su":"https://scitrials.org/trial/NCT03340792"},{"n":"NCT02110290","t":"Effects of an Adapted Ski/Snowboarding Program on Quality of Life in Children With Physical Disabilities","d":"This study is assessing quality of life in children with a physical disability who participate in the Children's Hospital Colorado Hospital Sports Program (HSP), where children with physical disabilities are able to participate in more organized sports and active programs with the use of adaptive equipment. This study would assess a child's self reported and parent perceived quality of life before and after child participation in HSP for the winter season. The investigators aim to determine the…","s":"Completed","tr":["Observational"],"o":["Mental Health","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02110290"},{"n":"NCT01105260","t":"Effects of an Early Wheelchair Reconditionong Program on Functional Independence in Spinal Cord-inured Individuals","d":"Reconditioning program during the chronic phase of the spinal cord-injury is well known for its beneficial effects, but there is no investigation in early rehabilitation consequences. Nevertheless, it may be justified : to increase oxygen uptake; to decrease the risks of medical complications; or to improve the mobility. The restrictive autonomy is due to different factors: firstly wheelchair users reduce their movement because they need technical or human help to achieve transfers; and…","s":"Terminated","tr":["Observational","Rehabilitation"],"o":["Blood Pressure","Quality of Life","Walking Function"],"st":[],"co":["France"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01105260"},{"n":"NCT06099340","t":"Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.","d":"Neurological disorders \\[such as Cerebral Vascular Accident (CVA) or Spinal Cord Injury (SCI)\\] are among the most costly health problems to society in industrialized countries. For those affected, they generate severe restrictions in mobility, significantly altering their quality of life. Deterioration in motor function after stroke or BM is closely linked to the level of force produced at joint level. This is influenced by adaptations (neurological and tissue) inherent to the pathophysiology…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":["Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06099340","su":"https://scitrials.org/trial/NCT06099340"},{"n":"NCT05591001","t":"Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries","d":"The tethered spinal cord is a common pathology in pediatric neurosurgery. Intraoperative neurophysiologic monitoring (IOM) has gained popularity over the past two decades as a clinical discipline that uses neurophysiologic techniques to detect and prevent iatrogenic neurologic injuries. IOM techniques are extensively used in adult neurosurgery and, in their principles, can be applied to the pediatric population. Inhalational agents cause a dose-dependent reduction in MEPs and are arguably…","s":"Completed","tr":["Drugs","Surgical Procedure"],"o":["Blood Pressure","Breathing Function","Mental Health"],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05591001"},{"n":"NCT01355991","t":"Effects of Anticholinergic or Long-Acting Beta 2 Agonist on FeNO and Pulmonary Function in SCI","d":"To determine the acute and chronic effects of a short course of treatment on spinal cord injured (SCI) individuals with either an anticholinergic agent (tiotropium) or with a β₂ agonist (Salmeterol) on: * Fraction of expired NO (FeNO) * Selected Biomarkers of inflammation in exhaled breath condensates (EBC) * Pulmonary function, as measured by pulmonary function tests and body plethysmography","s":"Unknown","tr":["Drugs"],"o":["Breathing Function"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01355991","su":"https://scitrials.org/trial/NCT01355991"},{"n":"NCT01600404","t":"Effects of Antimuscarinics on Cognition in Spinal Cord Injury","d":"Prospective evaluation of the cognitive function of in-house patients suffering from an acute traumatic spinal cord injury before and three months after the initiation of antimuscarinic treatment. The following hypothesis will be tested: Antimuscarinic treatment results in significantly worse cognitive test results three months after traumatic spinal cord injury compared to the pre-treatment results and the results of the control group.","s":"Completed","tr":["Drugs","Observational"],"o":["Bladder Function","Mental Health","Pain Management"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01600404"},{"n":"NCT07641101","t":"Effects Of App-Supported Transitional Care On Neurogenic Bladder In Spinal Cord Injury Patients","d":"This is a single-blind randomized controlled trial for patients with neurogenic bladder after incomplete spinal cord injury. Participants are randomly divided into two groups. The control group receives routine transitional nursing and telephone follow-up, while the intervention group gets 4-week app-supported transitional care including health education, bladder recording and online consultation. After intervention, bladder residual urine, urinary tract infection rate, self-care ability and…","s":"Completed","tr":[],"o":["Bladder Function","Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07641101"},{"n":"NCT04471714","t":"Effects of Baclofen on Presynaptic Inhibition in Humans","d":"This study examines the role of the GABA-B receptor in long-lasting presynaptic inhibition of primary afferents in human participants. Participants will come in for two visits, receiving baclofen (a GABA-B receptor agonist) on one visit and a placebo during the other. Electro-physiological measures will be use during both visit to asses presynaptic inhibition.","s":"Withdrawn","tr":["Drugs"],"o":["Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04471714"},{"n":"NCT04578574","t":"Effects of Bodily Illusion and tDCS on SCI-related Neuropathic Pain","d":"The purpose of this study is to evaluate the effect of a combination of two procedures: (1) Bodily Illusion (BI) and (2) Transcranial direct electrical stimulation (tDCS) on neuropathic pain.","s":"Completed","tr":["Electrical Stimulation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04578574"},{"n":"NCT01272011","t":"Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury","d":"Change to Reflect What Was Done and reason Changes Were Made. The purpose of this study is to determine (1) if a specific breathing treatment (intermittent hypoxia) can promote changes in breathing function and (2) if pairing breathing treatments (hypoxia) with locomotor training can enhance the benefits of walking recovery observed with locomotor training alone (without breathing treatments).","s":"Completed","tr":["Intermittent Hypoxia","Rehabilitation"],"o":["Breathing Function","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01272011"},{"n":"NCT02323945","t":"Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury","d":"Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Walking Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02323945","su":"https://scitrials.org/trial/NCT02323945"},{"n":"NCT02323698","t":"Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury","d":"Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand how caffeine may augment the effects of intermittent hypoxia on motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.","s":"Completed","tr":["Drugs","Intermittent Hypoxia"],"o":["Breathing Function","Motor Function","Plasticity","Walking Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02323698"},{"n":"NCT05622994","t":"Effects of CB1 Antagonist/Reverse Agonist Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury","d":"This is a placebo controlled study comparing Rimonabant 5 mg per day for 90 days with placebo for the same period. Objective is to improve walking abilities of spinal cord injury individuals (incomplete lesions) and demonstrate that it is a safe treatment in spinal cord injury population.","s":"Unknown","tr":[],"o":["Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05622994","su":"https://scitrials.org/trial/NCT05622994"},{"n":"NCT05630235","t":"Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI","d":"The main purposes of this study are to (1) measure the effect of CBD/CBD-A on pain symptoms, pain intensity, pain unpleasantness, and skin sensitivity to hot and cold temperatures; and (2) measure the effect of CBD on brain electrical activity with electroencephalography (EEG).","s":"Completed","tr":[],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05630235","su":"https://scitrials.org/trial/NCT05630235"},{"n":"NCT02122276","t":"Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions","d":"In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury. The alternation of muscular property was accompanied by the alternation of spinal circuitry property, and was related to the immobilization adaptation. Previous study showed that remobilization by continuous passive motion (CPM) for one month would restore the function of spinal circuitry in individual…","s":"Completed","tr":[],"o":["Spasticity"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02122276"},{"n":"NCT05008484","t":"Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury.","d":"Neurogenic osteoporosis is a common complication of spinal cord injury (SCI) that is associated with low impact bone fractures. It is concerning that more than 46,000 Veterans affected with SCI and are at risk of osteoporosis and possible low impact fractures. About fifty percent of all individuals with SCI will develop low impact fracture in their life time. The management of osteoporosis-related fractures can impose substantial economic burden on the health care system, the individual and the…","s":"Completed","tr":["Drugs","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)","Nutrition","Rehabilitation"],"o":["Bone Strength","Mental Health"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05008484"},{"n":"NCT01203150","t":"Effects of Exercise in People With Paraplegia","d":"This hypothesis-driven study will investigate effects of physical activity with or without a nutrient supplement known to increase body lean mass in adults with chronic paraplegia who have clusters of obesity and obesity-related secondary complications.","s":"Completed","tr":[],"o":["Blood Pressure","Motor Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01203150"},{"n":"NCT01202019","t":"Effects of Exercise in People With Tetraplegia","d":"This study is designed to assess the impact of exercise and supplementation on measures of fitness, function, and cardiovascular disease risk factors/modifiers in individuals with spinal cord injury (SCI). The primary purpose of this study is to improve fitness and function, reduce cardiovascular disease risks, and enhance oxidation of dietary and body fats in persons with chronic tetraplegia through acute exercise, exercise conditioning, and dietary supplementation. This study will test the…","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Blood Pressure"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01202019"},{"n":"NCT04821635","t":"Effects of FES-Rowing in Neurological Disorders (FES-ROW)","d":"The main objective of this project is to measure the increase in aerobic physical and metabolic capacities with a 6-month training on a rower assisted by electrostimulation of lower limbs in a population of adults with traumatic paraplegia.","s":"Withdrawn","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["France"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04821635","su":"https://scitrials.org/trial/NCT04821635"},{"n":"NCT07583576","t":"Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia","d":"Spinal cord injury (SCI)-related paraplegia is a complex neurological condition characterized by motor impairment, increased spasticity, and significant functional limitations in daily activities. Spasticity is one of the most common secondary complications after upper motor neuron lesions and can negatively affect rehabilitation outcomes, gait ability, and functional independence. This randomized controlled study aims to investigate the effects of Functional Electrical Stimulation (FES)…","s":"Not yet recruiting","tr":["Functional Electrical Stimulation (FES)"],"o":["Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07583576","su":"https://scitrials.org/trial/NCT07583576"},{"n":"NCT00332319","t":"Effects Of GW679769 On Bladder Nerve Function And Symptoms Of Overactive Bladder In Spinal Cord Injury Patients","d":"This is a two-part study in which Part A will assess the effects of GW679769 after 1 dose on the function of the nerves that supply the bladder. The technique for measuring the nerves function is called Neurometry. Part B will assess the effect of repeat doses of GW679769 on the bladder nerve function. Part B will also assess the effects of the drug on overactive bladder symptoms using a three-day patient diary.","s":"Terminated","tr":["Drugs"],"o":["Bladder Function"],"st":["California","Ohio","Pennsylvania"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00332319"},{"n":"NCT04164810","t":"Effects of Hydrotherapy on Neuropathic Pain and Pain Catastrophization in Spinal Cord Injury","d":"Spinal Cord Injury (SCI) is a spinal cord injury of traumatic origin with its main etiology being violence, which constitutes one of the greatest social and health problems worldwide. One of the complications with the greatest impact in people with SCI is Neuropathic Pain (NP). Pain, mainly chronic pain, has an effect on emotional states, cognition regarding pain and anticipation which leads to the catastrophization of the pain. This form of pain is related to chronic diseases that develop with…","s":"Unknown","tr":["Rehabilitation"],"o":["Pain Management"],"st":[],"co":["Colombia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04164810","su":"https://scitrials.org/trial/NCT04164810"},{"n":"NCT04467749","t":"Effects of In-Wheel Suspension","d":"Manual wheelchairs allow individuals with spinal cord injuries (SCI) to safely and effectively access their environment. However, continual exposure to whole body vibration (WBV) is one of many contributing factors to neck pain, back pain, and fatigue in wheelchair users with SCI. Vibration-reducing in-wheel suspension has the potential to mitigate issues associated with long-term manual wheelchair propulsion. Evidence is lacking on how well these systems work for reducing harmful shock and…","s":"Completed","tr":[],"o":["Pain Management","Quality of Life"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04467749"},{"n":"NCT05315115","t":"Effects of Intensive Chiropractic Care to Usual Care for Adults With Spinal Cord Injuries.","d":"To determine the effects of chiropractic care on spasticity, functional outcomes and quality of life in Spinal Cord Injuries in adults.","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Spasticity"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05315115"},{"n":"NCT02973438","t":"Effects of Intermittent Hypoxia (IH) on Metabolism and Dysglycemia, in Overweight/Obese Persons SCI","d":"The purpose of this research is to examine changes in blood glucose control and metabolism in individuals with SCI and non injured controls at rest and during exercise after five days of exposure to IH. This response will be compared with breathing normal room air (a SHAM control).","s":"Completed","tr":["Devices","Intermittent Hypoxia"],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02973438"},{"n":"NCT00154505","t":"Effects of Lateral Trunk Support on Spinal Alignment in Spinal Cord Injured Persons","d":"The effects of lateral trunk supports (LTS) in special seating on the spinal alignment of 17 spinal cord injured (SCI) subjects with scoliosis were studied using bi-planar radiographs. The LTS improved significantly the functional scoliotic spinal alignment in the frontal and sagittal planes regardless of the severity of scoliosis.","s":"Completed","tr":["Devices"],"o":["Trunk Control"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00154505"},{"n":"NCT07621900","t":"Effects of Lokomat Training on Dynamic Postural Stability in Incomplete Spinal Cord Injury","d":"The study aims to evaluate the effects of robotic-assisted gait training (Lokomat) on dynamic postural stability in patients with incomplete spinal cord injury (SCI). Participants will be randomized into two groups: one receiving robotic training and another receiving conventional postural stability exercises. The primary evaluation will use the Mini-BESTest, supplemented by objective gait analysis using wearable inertial sensors (IMUs) to measure symmetry, fluidity, and stability. A secondary…","s":"Active, not recruiting","tr":["Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07621900","su":"https://scitrials.org/trial/NCT07621900"},{"n":"NCT06190470","t":"Effects of Marijuana on Neuropathic Pain and Spasticity in Spinal Cord Injury Patients","d":"The goal of this clinical trial is to compare effects of marijuana or cannabis on neuropathic pain and spasticity in spinal cord injury patients. The main question is: Does the cannabis product from KhonKaen University reduce neuropathic pain and spasticity in spinal cord injury patients? The research design is a crossover study. The participants will be randomly into 2 groups: group 1 and group 2. The participants received either cannabis or placebo for 2 weeks. After completing treatment…","s":"Unknown","tr":[],"o":["Pain Management","Spasticity"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06190470","su":"https://scitrials.org/trial/NCT06190470"},{"n":"NCT06200493","t":"Effects of Maximum Strength and Acceleration Ability on Performance and Training in Wheelchair Sports","d":"The goal of this observational study is to learn about the relation between grip position and maximal strength and power in wheelchair rugby and basketball athletes. The main question is to investigate the relationship between maximal isometric force, acceleration, and sprint time. Participants will * pull in their sport wheelchair against a force transducer * push in their sport wheelchair from a force transducer * accelerate as fast as possible with one push * accelerate as fast as possible…","s":"Completed","tr":["Observational"],"o":["Hand Movement","Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06200493"},{"n":"NCT04194099","t":"Effects of Paired Associative Nerve Stimulation on Spinal Cord Injury Subjects","d":"This study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) combined with trans-spinal electrical stimulation (tsES) intervention on cortical excitability, brain structure, motor ability of lower limb in individuals with incomplete spinal cord injury. Twelve participants will be recruited in this study.","s":"Unknown","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Walking Function"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04194099","su":"https://scitrials.org/trial/NCT04194099"},{"n":"NCT05535400","t":"Effects of Physical-Psychological Integrative Intervention on SCI Patient: a Pilot Randomized Controlled Trial","d":"Spinal cord injury (SCI) is a neurological disorder that leads to \"partial or complete loss of people's motor and/ or sensory function below the level of the injury\". The PPI intervention group participants will indicate significantly greater improvements when compared with those in control group in the minutes of performing the moderate-to-rigorous physical activity, depression, chronic pain and mindfulness skills and quality of life at post-intervention, and three months follow-up. The use of…","s":"Completed","tr":["Devices"],"o":["Mental Health","Pain Management","Quality of Life","Sensory Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05535400"},{"n":"NCT04967911","t":"Effects of PNF on Shoulder Pain in Paraplegic Manual Wheel Chair Users","d":"This project was a Randomized control trial conducted to check the Effects of Proprioceptive Neuromuscular Facilitation on Shoulder Pain due to chronic impingement syndrome in paraplegic Manual Wheelchair users after Spinal Cord Injury so that we can have best treatment option for patients with shoulder pain due to manual wheelchair usage. duration was of 6months,convenient sampling was done, subject following eligibility criteria from Spine welfare trust center, Nawaz Sharif social security…","s":"Completed","tr":[],"o":["Pain Management"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04967911"},{"n":"NCT03482037","t":"Effects of Rec 0/0438 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Injury","d":"Study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of Rec 0/0438 in subjects with neurogenic detrusor overactivity due to spinal cord injury","s":"Completed","tr":["Drugs"],"o":[],"st":[],"co":["Czechia","France","Poland","Portugal"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03482037"},{"n":"NCT03851302","t":"Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS","d":"Rehabilitation interventions such as physical training and neural stimulation after spinal cord injury (SCI) have been shown to increase neural plasticity. However, both physical training and neural stimulation require a large number of repetitions, and the retention of the intervention effects may be fleeting. In this proposal the investigators will test Remote ischemic conditioning (RIC), which has been shown to promote neural plasticity and has practical and theoretical advantages. RIC…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Plasticity"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03851302"},{"n":"NCT05398913","t":"Effects of Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury","d":"Randomized placebo-controlled safety and feasibility study with crossover design (3 arms). Placebo or Rimonabant 2.5mg or Rimonabant 5mg will be administered for 5 days. Exploratory efficacy will be tested using six-min walking test.","s":"Completed","tr":["Drugs","Safety"],"o":["Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05398913"},{"n":"NCT03611803","t":"EFFECTS OF ROBOTIC TRAINING ON VASCULAR HEALTH OF INDIVIDUALS WITH SCI","d":"Robotic devices may be used to help the gait and balance of individuals with Spinal Cord Injury (SCI). However, as such devices may allow individuals to engage in physical activity in an upright position, there may be significant benefit on the vascular health of patients with SCI. This study will assess the effect of a robotic-assisted gait-training (exoskeleton) program on central and peripheral hemodynamic markers in people with SCI.","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Blood Pressure","Trunk Control","Walking Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03611803"},{"n":"NCT00127439","t":"Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury","d":"The purpose of this study is to collect data comparing two means of providing locomotor training: manual and robotic and the possible differential effects it may have on walking ability for persons with spinal cord injury (SCI).","s":"Completed","tr":["Rehabilitation"],"o":["Trunk Control","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00127439"},{"n":"NCT07343583","t":"Effects of Sacral and Tibial Stimulation on Bladder Function in Subacute Suprasacral Spinal Cord Injury","d":"Suprasacral spinal cord injury (SCI) frequently leads to neurogenic detrusor overactivity (NDO), resulting in elevated bladder storage pressures, urinary incontinence, and an increased risk of upper urinary tract damage. Early regulation of bladder function is a key objective of SCI rehabilitation, particularly during the subacute phase when pathological spinal reflex pathways are still developing. Pharmacological treatments are considered first-line therapy for NDO; however, adequate control…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Bladder Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07343583","su":"https://scitrials.org/trial/NCT07343583"},{"n":"NCT01201759","t":"Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)","d":"The overall study objectives are to examine whether: 1. Persons with spinal cord injury (SCI) having elevated body mass are at greater cardiovascular disease (CVD) risk for fasting and postprandial lipidemia, glycemia, and vascular inflammation than persons with SCI having 'normal' body mass, and 2. An inexpensive, low-risk, widely-available pharmacotherapy safely reduces CVD risks associated with fasting and postprandial lipidemia, glycemia, and vascular inflammation.","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01201759"},{"n":"NCT04160858","t":"Effects of Spinal Cord Injury Exercise Guidelines","d":"Over 85,000 Canadians live with a spinal cord injury (SCI). The vast majority experience chronic pain from neuropathic or musculoskeletal origins, with many reporting the pain to be more physically, psychologically and socially debilitating than the injury itself. Currently, pharmaceuticals are the front line treatment recommendation for SCI pain, despite having many side-effects and giving minimal relief. Alternatively, studies conducted in controlled lab and clinical settings suggest that…","s":"Unknown","tr":["Rehabilitation"],"o":["Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04160858","su":"https://scitrials.org/trial/NCT04160858"},{"n":"NCT00142714","t":"Effects of Spinal Cord Injury on Female Sexual Response","d":"The long term aims of this project are to 1) Understand the effect of varying degrees and levels of SCI and dysfunction(SCI/D)on females sexual response: 2) Identify the specific neuronal pathways involved in female sexual responses; and 3) Develop and evaluate new assessment and treatment methods for neurogenic sexual dysfunction in women.","s":"Unknown","tr":["Observational"],"o":["Sexual Function"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00142714","su":"https://scitrials.org/trial/NCT00142714"},{"n":"NCT02342080","t":"Effects of System Suspended Robotic Lokomat Gait in Patients With Incomplete Spinal Cord Injury","d":"Patients with incomplete spinal cord injury","s":"Completed","tr":["Devices"],"o":["Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02342080"},{"n":"NCT04910412","t":"Effects of tDCS With Gait Training on Leg Performance in Incomplete Spinal Cord Injury","d":"This study aim to investigate the effects of anodal transcranial direct current stimulation combined with gait training for 5 consecutive session on gait performance, balance, sit to stand performance and quality of life in persons with incomplete SCI at post intervention, 1-month follow-up and 2-month follow up","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04910412"},{"n":"NCT04241003","t":"Effects of the SmartDrive on Mobility, Activity and Shoulder Pain Among People With SCI Using Manual Wheelchairs","d":"This is a prospective study of manual wheelchair users with spinal cord injury (SCI). The users will be their own controls. The primary purpose of the study is to evaluate the ability of the power assist device SmartDrive to increase the ability to be mobile.","s":"Completed","tr":["Devices"],"o":["Pain Management"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04241003"},{"n":"NCT01404065","t":"Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury","d":"The purpose of this study is to investigate the effects of Transcranial Direct Current Stimulation (tDCS) combined with watching a visual illusion on chronic pain due to spinal cord injury. The investigators hypothesize that active tDCS will reduce pain in subjects with spinal cord injury when compared to sham stimulation. The investigators will also measure changes in EEG data (alpha and beta frequencies) as well as motor cortex excitability.","s":"Terminated","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01404065"},{"n":"NCT02899637","t":"Effects of Transcranial Magnetic Stimulation in Incomplete Spinal Cord Injury","d":"The main objective is to conduct a study protocol to investigate the effects of repetitive Transcranial Magnetic Stimulation (rTMS) on sensory and motor performance of individuals with incomplete spinal cord injury (iSCI) . A double-blind randomized sham-controlled trial of patients with iSCI will be conducted.","s":"Unknown","tr":["Brain Stimulation"],"o":["Regeneration"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02899637","su":"https://scitrials.org/trial/NCT02899637"},{"n":"NCT03137108","t":"Effects of Transcutaneous Spinal Cord Stimulation on Residual Voluntary Motor Control in Individuals With Incomplete Spinal Cord Injury","d":"Recently, a transcutaneous protocol of electrical spinal cord stimulation (tSCS) has been developed. It was suggested, that this method could be used to improve the therapy process after a spinal cord injury (SCI). The aim of this study is to investigate the immediate effects of tSCS with different stimulation modalities on voluntary motor control in patients with incomplete SCI.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03137108"},{"n":"NCT03249454","t":"Effects of Transcutaneous Spinal Direct Current Stimulation in Incomplete Spinal Cord Injury","d":"The purpose of the study is to investigate the effects of a novel therapeutic approach with transcutaneous spinal direct current stimulation (tsDCS) to promote functional recovery and spasticity in chronic spinal cord injury (SCI).","s":"Completed","tr":["Transcranial Direct Current Stimulation (tDCS)","Transcutaneous Stimulation"],"o":["Blood Pressure","Spasticity"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03249454"},{"n":"NCT04586777","t":"Effects of Transvertebral Direct Current Stimulation in Humans","d":"This study will evaluate the effects of non-invasive stimulation of the spinal cord in people with spinal cord injury.","s":"Terminated","tr":["Devices"],"o":["Plasticity"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04586777"},{"n":"NCT01037088","t":"Effects of Vaporized Marijuana on Neuropathic Pain","d":"This study theorized that a low dose of vaporized cannabis could alleviate nerve injury pain.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01037088"},{"n":"NCT00167856","t":"Effects of Venlafaxine on Chronic Neuropathic Pain Following Spinal Cord Injury","d":"The purpose of this study is to evaluate the pain-relieving effects of venlafaxine hydrochloride (Effexor) in chronic neuropathic (burning, shock-like, electric) pain after spinal cord injury (SCI). Although a number of medications have been used to treat SCI pain, no drug has been consistently helpful, and, therefore, many people with SCI continue to have difficult chronic pain. Venlafaxine is a new anti-depressant drug that has not been tested for use in SCI neuropathic pain, but has been…","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00167856"},{"n":"NCT03622710","t":"Effects of Walking Training on Different Surfaces on Walking Ability in Ambulatory Patients With Spinal Cord Injury","d":"The study compares effects of 4-week walking training program on a walking track with difference surface \\[WTDS\\] and a firm ground on functional ability of ambulatory individuals with incomplete spinal cord injury \\[iSCI\\], using within- and between-group comparisons.","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03622710"},{"n":"NCT06876285","t":"Effects of Wheelchair Treadmill and Conventional Exercises on Trunk Balance in Spinal Cord Injury Patients","d":"This study aims to determine whether wheelchair treadmill exercises improve trunk balance and stability compared to conventional wheelchair exercises. Trunk balance is essential for mobility, transfers, and daily activities in individuals with spinal cord injury (SCI). The study includes individuals with SCI who use manual wheelchairs. Participants will be randomly assigned to: A control group performing conventional wheelchair exercises, an experimental group performing wheelchair treadmill…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06876285","su":"https://scitrials.org/trial/NCT06876285"},{"n":"NCT01587170","t":"Effects of Zolmitriptan on Sensory Transmission After Spinal Cord Injury","d":"After spinal cord injury, patients develop a spastic syndrome that is characterized by hyperactive reflexes, increased muscle tone, clonus and involuntary muscle spasms. The neuronal mechanisms behind the development of spasticity remain largely unknown, though animal experiments have shown that changes occur both at the level of the motoneuron and sensory neurons. This project aims to examine the changes that occur in the modulation of sensory afferent transmission after spinal cord injury…","s":"Completed","tr":["Observational"],"o":["Blood Pressure","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01587170"},{"n":"NCT04936217","t":"Efficacy and Safety of a Continent Cutaneous Urinary Diversion in Spinal Cord Injury Patients","d":"Continent Cutaneous Urinary Deviation (CUD), using the Mitrofanoff, Yang-Monti or Casale principle, is offered to patients with neurological diseases who are unable to perform intermittent catheterisation through the native urethra due to upper limb disability. There is very little data in the literature examining the long-term efficacy and complications of this technique. The main objective of this study is to evaluate the effectiveness of long-term CUDs in spinal cord injury patients. The…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Arm Movement","Bladder Function","Quality of Life"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04936217"},{"n":"NCT01329757","t":"Efficacy and Safety of Growth Hormone Treatment in Spinal Cord Injury","d":"Objectives: To evaluate the efficacy and safety of one year treatment based on daily doses of exogenous growth hormone (GH) in patients with traumatic spinal cord injury. The first six months the pharmacological treatment will be associated to rehabilitation treatment. The main hypothesis is that GH can improve motor function of patients with traumatic spinal cord injury below the lesion level. The hypothesis is based on possible effects of GH at muscle and synaptic level. GH can also promote…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Motor Function","Pain Management","Plasticity","Quality of Life","Regeneration","Sensory Function","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01329757"},{"n":"NCT04213131","t":"Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury","d":"There is evidence that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) can differentiate into oligodendrocytes and neurons, and improve the recovery of nerve function, which strongly suggests the feasibility and effectiveness of hUCB-MSCs as an intervention treatment for spinal cord injury. At present, there are only a few clinical centers in which hUCB-MSCs transplantation for treatment of chronic spinal cord injury has been performed and a certain degree of efficacy has…","s":"Unknown","tr":[],"o":["Regeneration","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04213131","su":"https://scitrials.org/trial/NCT04213131"},{"n":"NCT00750061","t":"Efficacy and Safety of Lithium Carbonate in the Treatment of Chronic Spinal Cord Injuries","d":"This is a randomized, placebo-controlled, double-blinded trial. Forty patients will be randomized into two groups. The subjects in the Treatment Group will be administered with lithium carbonate, while the Control Group will receive placebo. Each subject will receive oral lithium carbonate or placebo for six weeks. In the treatment group, the dose will be adjusted according to the serum lithium level while in the control group there will be a sham adjustment. The outcomes will be assessed 6…","s":"Completed","tr":["Drugs"],"o":["Pain Management","Quality of Life"],"st":[],"co":["China","Taiwan"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00750061"},{"n":"NCT00745095","t":"Efficacy and Safety of Standard Oral Colonoscopic Preparations With or Without Neostigmine Compared to Pulse-Irrigation Colonic Lavage","d":"The annual incidence of colorectal cancer in the US during 2005 was approximately 150,000 cases and this neoplasm claimed 56,000 lives (American Cancer Society). Detection (and removal) of colonic polyps is now the central strategy in reducing the risk of colon cancer. Thus, failure to detect and remove small cancers and polyps can have dire consequences. Although it has not been shown that persons with spinal cord injury (SCI) have an increased risk of this disease, there is no reason to…","s":"Completed","tr":["Drugs"],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00745095"},{"n":"NCT00421083","t":"Efficacy and Safety of Tadalafil in Subjects With Erectile Dysfunction Caused by Spinal Cord Injury","d":"This is a study of the efficacy and safety of on-demand dosing of tadalafil or placebo administered for 12 weeks to men with erectile dysfunction caused by spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Quality of Life","Sexual Function"],"st":["Indiana"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00421083"},{"n":"NCT00844480","t":"Efficacy and Safety of Zoledronic Acid in Acute Spinal Cord Injury: Prevention of Bone Loss","d":"This is a double-blind, randomized, placebo-controlled trial of zoledronic acid, 5mg, to be administered intravenously to people who have suffered an acute spinal cord fracture. The goal is to evaluate if zoledronic acid can prevent the acute bone loss seen in this population. Outcome measures will include bone density determinations over a one year period.","s":"Terminated","tr":["Drugs"],"o":["Bone Strength"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00844480"},{"n":"NCT04815967","t":"Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity","d":"Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension safety trial.","s":"Terminated","tr":["Drugs"],"o":["Arm Movement","Spasticity"],"st":["California","Idaho","South Carolina","Texas"],"co":["Hungary","Poland","United States"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04815967"},{"n":"NCT06765070","t":"Efficacy and Usability of the EXPLORER Exoskeleton in Children With Neurodevelopmental Disorders in Natural Environments","d":"Neurodevelopmental disorders often lead to abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as an inability to stand and walk. EXPLORER is a robotic gait exoskeleton designed to rehabilitate children with motor disabilities in home and outdoor environments. The aim of this study is to evaluate the efficacy and usability of EXPLORER in children with motor disability within their natural settings, including home and community environments.","s":"Active, not recruiting","tr":["Devices","Exoskeleton"],"o":["Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Spain"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06765070"},{"n":"NCT05343130","t":"Efficacy of a Brain-Computer Interface Controlled Functional Electrical Stimulation Therapy for Spinal Cord Injury Neurorehabilitation","d":"The study's main goal is to determine the efficacy of a therapy with brain-computer interface controlled functional electrical stimulation for neurorehabilitation of spinal cord injury patients' upper limbs. For this purpose, a randomized controlled trial will be performed to compare the clinical and physiological effects of the brain-computer interface therapy with those of a sham intervention comprised by the application of functional electrical stimulation independently of brain-computer…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Mexico"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05343130","su":"https://scitrials.org/trial/NCT05343130"},{"n":"NCT07171489","t":"Efficacy of a Wearable Noninvasive Neuromodulation Device","d":"The aim of this study is to investigate the potential of transcutaneous neuromodulation (TNM) to treat slow colonic transit and constipation, termed the Neurogenic bowel dysfunction (NBD), in people with SCI. In this project, the study team will investigate the impact of an active treatment intervention vs. a sham control intervention on NBD symptoms in patients with SCI. The study hypotheses: * The proposed TNM treatment at a leg point will reduce NBD symptoms between baseline and…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Bowel Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07171489","su":"https://scitrials.org/trial/NCT07171489"},{"n":"NCT02554201","t":"Efficacy of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction","d":"The main goal to treat early NLUTS is to relieve lower urinary tract syndrome and prevent from late complications. The present study is to evaluate the efficacy of electrical pudendal nerve stimulation (EPNS) and transanal/transvaginal electrical stimulation (TES) in NLUTD.The study design consists of a non-randomized, parallel controlled trial. A total of 60 eligible patients will be involved and divided into EPNS or TES group according to their location of medical treatment. The primary…","s":"Completed","tr":["Electrical Stimulation"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02554201"},{"n":"NCT06974968","t":"Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial","d":"Purpose: This clinical trial is studying an investigational cell therapy called XS228-a lab-made stem cell product designed to help repair damaged nerves in the spinal cord. The goal is to see if XS228 is safe and can improve movement, sensation, and function in people with recent spinal cord injuries. Study Treatment: XS228 contains specialized nerve-supporting cells derived from human stem cells. These cells are injected into the spinal fluid (intrathecal administration) in a single dose. Who…","s":"Not yet recruiting","tr":["Safety","Stem Cells"],"o":["Bladder Function","Bowel Function","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06974968","su":"https://scitrials.org/trial/NCT06974968"},{"n":"NCT02198833","t":"Efficacy of Micro-Patterned Foley Catheter to Reduce Catheter-Associated Urinary Tract Infection","d":"The purpose of this study is to determine if the study Foley catheter with its patterned external surface can delay the time to the onset of urinary tract infection in spinal cord injury patients who are dependent on a Foley catheter for drainage of their urinary bladder.","s":"Terminated","tr":["Devices"],"o":["Bladder Function"],"st":["Florida","Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02198833"},{"n":"NCT06393205","t":"Efficacy of Naso-Esophageal Tube Feeding in Patients With High Cervical Spinal Cord Injury.","d":"The goal of this clinical trial is to compare the differences in Pneumonia situation and nutritional status between Patients With High Cervical Spinal Cord Injury using Naso-Esophageal Tube Feeding and Nasogastric Tube. Patients will be randomly divided into an observation group and a control group, all receiving routine rehabilitation treatment. On this basis, the observation group will use Naso-Esophageal Tube Feeding for enteral nutrition support, while the control group will use Nasogastric…","s":"Unknown","tr":["Nutrition"],"o":["Breathing Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06393205","su":"https://scitrials.org/trial/NCT06393205"},{"n":"NCT06464744","t":"Efficacy of rTMS Treatment After Spinal Cord Injury","d":"There is accumulating evidence that neuromodulation by repetitive transcranial magnetic stimulation (rTMS) of the motor cortex holds promise as a treatment for rehabilitation of motor function following a spinal cord injury. This study is designed to assess the clinical potential of non-invasive stimulation of the primary motor cortex to improve motor functions.The results will help to evaluate the clinical relevance of motor cortex stimulation for motor functions in patients with spinal cord…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["Norway"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06464744","su":"https://scitrials.org/trial/NCT06464744"},{"n":"NCT06553469","t":"Efficacy of Sacral Nerve Modulation on Urinary and Defecation Dysfunction After Spinal Cord Injury：A Prospective, Single-arm Study","d":"The aim of this study is to investigate the long-term efficacy of sacral nerve modulation surgery in the treatment of neurogenic lower urinary tract dysfunction caused by incomplete spinal cord injury, as well as its preventive effect on complications of neurogenic lower urinary tract dysfunction. We will use urodynamic examination results such as maximum bladder capacity and detrusor leak point pressure, combined with renal function and urinary ultrasound results, as our evaluation indicators…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06553469","su":"https://scitrials.org/trial/NCT06553469"},{"n":"NCT01803919","t":"Efficacy Study of Antimicrobial Catheters to Avoid Urinary Infections in Spinal Cord Injured Patients","d":"The purpose of this trial is to make a comparison between the use of antiseptic silver alloy-coated silicone urinary catheters and the use of conventional silicone urinary catheters in spinal cord injured patients to prevent urinary infections.","s":"Terminated","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Chile","Italy","Portugal","Spain","Turkey (Türkiye)"],"lc":20,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01803919"},{"n":"NCT01023269","t":"Efficacy Study of Pudendal Neuromodulation for the Treatment of Neurogenic Overactive Bladder","d":"The study is designed to demonstrate that treatment with low level stimulation of the bladder muscles reduces symptoms of urinary incontinence in comparison with no stimulation.","s":"Terminated","tr":["Electrical Stimulation"],"o":["Bladder Function"],"st":[],"co":["Belgium","France","Germany","Italy","Netherlands","United Kingdom"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01023269"},{"n":"NCT02473614","t":"Efficacy Study of the Music Glove Patients With Spinal Cord Injuries","d":"Investigators are trying to determine the therapeutic effect of the music glove and conventional hand exercise program to patients with spinal cord injuries. All participants will be randomized into two groups: AB and BA. They will all exercise at least 3 times a week for 3 weeks with minimum of 3 hours of exercise time per week. Participants will receive the other intervention at their 3 week post-therapy follow-up visits. Clinical evaluations will be performed at baseline 1 and 2 (3 to 10…","s":"Completed","tr":["Devices"],"o":["Hand Movement","Motor Function"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02473614"},{"n":"NCT06421753","t":"Efficiency of Spatially Distributed Sequential Stimulation (Sdss) for Functional Electrical Stimulation (FES) of Upper Motor Neuron Syndrome (UMR) Patients","d":"To determine whether Spatially Distributed Sequential Functional Electrical Stimulation is more effective than Standard Electrical Stimulation During Functional Electrical Stimulation in Upper Motor Neuron Patients","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06421753"},{"n":"NCT06624566","t":"EINTER PROGRAM in Spinal Cord Injury Patients","d":"This study consists of the implementation of a therapeutic physical exercise program in a group setting in patients with spinal cord injury admitted to the Miguel Servet University Hospital in Zaragoza. This program consists of performing strength and endurance exercises from Monday to Friday with a duration of approximately 45 minutes each session. The groups are created in such a way that the subjects in each group are homogeneous. This homogeneity is classified according to whether or not…","s":"Completed","tr":[],"o":["Motor Function","Trunk Control","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06624566"},{"n":"NCT01701388","t":"EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)","d":"This study seeks to test the safety and efficacy of the Esko device in SCI population and in populations with similar neurological weakness to the SCI population. The device can currently stand from a seated position, walk, and turn and sit down. Our hypothesis are as follows: * Hypothesis 1: We hypothesize that the Ekso subject will significantly improve balance while wearing the device as noted by subject's ability to safely achieve standing balance for 30 sec without loss of balance. *…","s":"Active, not recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01701388","su":"https://scitrials.org/trial/NCT01701388"},{"n":"NCT03513783","t":"Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation","d":"Patients with C5 or C6 tetraplegia have paralysis of the triceps brachii. Elbow extension can be surgically restored by transferring the tendon from a preserved muscle onto the tendon of the paralyzed triceps brachii. The most frequently used method transfers the posterior deltoid tendon. However, transferring the posterior deltoid can create an imbalance in the shoulder joint and this technique is not recommended when the clavicular head of the pectoralis major is weak. In such cases, a…","s":"Terminated","tr":["Rehabilitation","Surgical Procedure"],"o":["Arm Movement"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03513783"},{"n":"NCT00010374","t":"Electrical Activation of The Diaphragm for Ventilatory Assist","d":"OBJECTIVES: The objectives of this study are to test the Diaphragm Pacing Stimulation (DPS) System for treating chronic ventilatory insufficiency in persons with respiratory muscle paralysis. The hypothesis being tested in the clinical trial is that laparoscopic stimulation of the diaphragm at the motor point with intramuscular electrodes is safe and effective in providing significant ventilatory support to individuals who are otherwise dependant on a mechanical ventilator. Patients in our…","s":"Completed","tr":["Devices"],"o":["Breathing Function"],"st":["Colorado","Georgia","Ohio","Texas"],"co":["Canada","United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00010374"},{"n":"NCT00011570","t":"Electrical Control of Bladder in Spinal Cord Injury Patients","d":"The investigators will continue their work with implanted stimulators to improve bladder and bowel function. Electrical stimulation produces simultaneous contraction of sphincters with the target organs, making emptying difficult. By optimizing electrode placement, employing a new electrode design and waveform choice, it is hoped to improve the 50% of subjects able to defecate with existing approaches. This is part of a multi-center study with multiple support sources, including Rehab R\\&D, PVA…","s":"Completed","tr":["Electrical Stimulation"],"o":["Bladder Function","Bowel Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00011570"},{"n":"NCT07792616","t":"Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity","d":"Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain. Oral medications are the usual first-line treatment, but many people report limited benefit or side effects. This study examines a non-surgical method called transcutaneous spinal stimulation. Surface electrodes are placed on the lower back and on the abdomen, and an electrical current is…","s":"Active, not recruiting","tr":["Drugs","Electrical Stimulation","Surgical Procedure","Transcutaneous Stimulation"],"o":["Pain Management","Spasticity","Walking Function"],"st":["Mississippi"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07792616"},{"n":"NCT07768761","t":"Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis","d":"The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis. Specifically, surface electrical stimulation or previously implanted stimulator will be used to stimulate the muscles during various forms of exercise training with the primary focus on improving overall endurance and maximal power output. For this study, peripheral stimulating…","s":"Recruiting","tr":["Electrical Stimulation","Rehabilitation"],"o":["Leg Movement","Motor Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07768761"},{"n":"NCT07493889","t":"Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries","d":"Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden. Electrical stimulation has been suggested as an adjunctive therapy to promote wound healing by enhancing angiogenesis, improving cell migration, and restoring local bioelectric fields. This randomized controlled pilot study aims to evaluate the clinical and psychosocial effects of high-voltage monophasic…","s":"Completed","tr":["Electrical Stimulation"],"o":["Mental Health","Pain Management","Pressure Sores","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07493889"},{"n":"NCT02978638","t":"Electrical Stimulation for Continence After Spinal Cord Injury","d":"This study aims to improve continence and voiding of patients with spinal cord injury using electrical stimulation. The Finetech Vocare Bladder System is an implantable sacral nerve stimulator for improving bladder and bowel function in patients with spinal cord injury (SCI). It has been commercially available in Britain and other countries since 1982, and has been used in thousands of patients with SCI to improve bladder, bowel and sexual function. It received FDA approval in 1998 under…","s":"Active, not recruiting","tr":[],"o":["Bladder Function"],"st":["California","New Mexico","Ohio"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02978638","su":"https://scitrials.org/trial/NCT02978638"},{"n":"NCT05103436","t":"Electrical Stimulation for Spasticity in Spinal Cord Injury","d":"This study examines the immediate and long-term effects of lumbosacral TENS on spasticity and residual voluntary force control in spinal cord injury in comparison to no TENS. Participants in the intervention group will receive 2 months of TENS. Participants in the control group will receive TENS after a 2-month delay. Modified Ashworth score and pendulum test will be used to assess spasticity and force control. Electrophysiological measures will be used to assess the activity profile of…","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05103436","su":"https://scitrials.org/trial/NCT05103436"},{"n":"NCT04307303","t":"Electrical Stimulation of Abdominal Muscles for Bowel Management in People With Spinal Cord Injury","d":"A well-managed bowel program is an essential part of daily life for many people with a SCI. Nevertheless, constipation is frequently reported (42-95%). Constipation embraces a spectrum of harms including both physical \\& psychological distress. Initial exploratory studies suggest abdominal FES may be useful for decreasing overall bowel management time, decreasing colonic transit time and reducing discomfort. The current study will seek to reproduce previous findings in a 12 week study, using…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Bowel Function","Mental Health","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04307303"},{"n":"NCT02080039","t":"Electrical Stimulation of Denervated Muscles After Spinal Cord Injury","d":"In this study the following hypotheses will be tested: Electrical stimulation of the gluteal muscle (buttocks) leads to 1. an increase in the thickness of the gluteal muscle 2. a decrease in the thickness of the fat of the buttock area 3. a change in the distribution of the middle and maximal seating pressure to a more consistent pressure 4. an increase in well-being of the patients.","s":"Terminated","tr":["Electrical Stimulation"],"o":["Mental Health"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02080039"},{"n":"NCT06531837","t":"Electroencephalographic Characteristics of Chronic Pain in Patients With Spinal Cord Injury","d":"The diagnosis of chronic pain currently lacks objective and quantifiable biomarkers. This study aims to observe the EEG characteristics of patients with chronic pain following spinal cord injury and subsequently administer analgesic interventions with remifentanil, esketamine, flurbiprofen, and spinal cord stimulation. The correlation between EEG features and pain intensity will be examined. The research aims to advance the objectification of chronic pain diagnosis and treatment.","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06531837","su":"https://scitrials.org/trial/NCT06531837"},{"n":"NCT06527417","t":"Electromyography-Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness in SCI Patients","d":"The aim of this study was to investigate the effect of electromyography (EMG) triggered electrical stimulation (ES) applied to multifidus and erector spinae muscles on trunk balance in patients with complete thoracic spinal cord injury (SCI). The fundamental questions that investigators want to answer are as follows: * \\[question 1\\]: \"Does multifidus and erector spinae EMG ES improve trunk balance in patients with complete SCI?\" * \\[question 2\\]: \"Does multifidus and erector spinae EMG ES…","s":"Completed","tr":["Electrical Stimulation"],"o":["Trunk Control"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06527417"},{"n":"NCT03806023","t":"EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals","d":"Most individuals with spinal cord injury (SCI) have residual nerve circuits. The investigators aim to strengthen those circuits to improve motor recovery after injury. To do this, the investigators are attempting to pair electrical and magnetic stimulation with physical training targeted toward the connections between nerve circuits. Past studies by other groups have shown that synapse strength can be improved temporarily after a short period of paired stimulation between the brain (motor…","s":"Terminated","tr":["Electrical Stimulation","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement","Motor Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03806023"},{"n":"NCT07705256","t":"EMG-Directed Virtual-Reality Training for Motor Stroke Rehabilitation","d":"This study is testing whether rehabilitation using muscle activity signals can help improve arm and hand movement in people after stroke or spinal cord injury. In the main study, participants will use a virtual-reality feedback system that is controlled by surface electromyography (EMG). Surface EMG uses sensors placed on the skin to detect muscle activity. The feedback will help participants practise upper limb movements during rehabilitation. A related sub-study will run alongside the main…","s":"Recruiting","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Hand Movement","Mental Health","Pain Management","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07705256"},{"n":"NCT06169696","t":"EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis","d":"Neuralis is an innovative assistive technology designed for individuals with severe neuromuscular conditions, enabling wheelchair control through EEG signals. This study aims to assess the safety, feasibility, and efficacy of Neuralis in restoring mobility and independence. The device is a discreet EEG headset which specializes in decoding signals from visual cortex, allowing users to initiate precise wheelchair movements through focused attention. This research seeks to demonstrate Neuralis'…","s":"Unknown","tr":["Brain Stimulation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06169696","su":"https://scitrials.org/trial/NCT06169696"},{"n":"NCT07430904","t":"Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury","d":"Antimicrobial resistance is a major public health concern that worsens healthcare outcomes. Antibiotic resistant organisms occur more often in Veterans with spinal cord injury or disease (SCI/D) given their frequent exposure to antibiotics, recurrent hospitalizations, and common use of urinary catheter devices. Veterans with SCI/D are also at risk for overtreatment with antibiotics when they do not need them, particularly for over-diagnosed urinary tract infections. The investigators plan to…","s":"Not yet recruiting","tr":[],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07430904","su":"https://scitrials.org/trial/NCT07430904"},{"n":"NCT07419646","t":"EmpowerSpine Program","d":"Chronic pain affects over 60% of individuals living with spinal cord injuries (SCI), significantly impairing their daily lives and overall well-being. Traditional treatments like medications often provide limited relief and come with unwanted side effects. Recognizing this gap, the EmpowerSpine program was co-developed as an innovative, online, multidisciplinary pain management solution tailored for individuals with SCI. EmpowerSpine equips participants with evidence-based tools, including…","s":"Not yet recruiting","tr":[],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07419646","su":"https://scitrials.org/trial/NCT07419646"},{"n":"NCT07227727","t":"Endothelial Dysfunction After SCI","d":"This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord…","s":"Recruiting","tr":[],"o":["Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07227727","su":"https://scitrials.org/trial/NCT07227727"},{"n":"NCT03545867","t":"Energetic Response to Feeding and Exercise in SCI","d":"This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03545867"},{"n":"NCT00572845","t":"Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation","d":"The purpose of this study is to determine if there is a relationship between spasticity and relative changes in Basal Energy Expenditure in persons with spinal cord injury.","s":"Terminated","tr":[],"o":["Spasticity"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00572845"},{"n":"NCT02815878","t":"Enhance Wellness for Individuals With Long-Term Physical Disabilities","d":"This project is an adaptation trial, testing the efficacy of an evidence-based community wellness program, Enhance Wellness (http://www.projectenhance.org/enhancewellness.aspx), in a sample of middle and older-aged adults living with multiple sclerosis, spinal cord injury, post-polio syndrome and muscular dystrophy.","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02815878"},{"n":"NCT03952416","t":"Enhanced Medical Rehabilitation for Spinal Cord Injury","d":"Background: Patient engagement is a cornerstone of patient-centered care. Studies show that an increased level of patient engagement in medical rehabilitation is associated with greater functional recovery. To achieve higher levels of patient engagement, it is important to improve therapists' techniques for goal setting and clinician-therapist communication. Thus, we have developed a manualized intervention for post-acute rehabilitation, Enhanced Medical Rehabilitation (EMR), which is an…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03952416"},{"n":"NCT00047619","t":"Enhancement of Pressure Healing With Pulsatile Lavage","d":"The purpose of this study is to investigate the use of pulsatile lavage to enhance the healing of pressure ulcers in individuals with spinal cord injury (SCI). The goals will be achieved using a repeated-measures double-blinded randomized controlled study of individuals with SCI who have pelvic region pressure ulcers. A total of 60 subjects will be recruited to this study. Participants will be randomly assigned to a treatment or control group. Pulsatile lavage treatment will be administered to…","s":"Completed","tr":["Surgical Procedure"],"o":["Pressure Sores","Quality of Life"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00047619"},{"n":"NCT06137443","t":"Enhancing Balance and Mobility in Incomplete Spinal Cord Injury","d":"The goal of this clinical trial is to compare the effects of balance therapy with an overground gait trainer in incomplete spinal cord injury (SCI). The main questions it aims to answer are: * Is balance therapy with an overground gait trainer effective in improving functional ambulation in SCI? * Is balance therapy with an overground gait trainer effective in enhancing Activities of Daily Living in SCI? Participants treated with either: • Overground gait trainer along with conventional…","s":"Completed","tr":["Devices"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06137443"},{"n":"NCT03237234","t":"Enhancing Corticospinal Activation for Improved Walking Function","d":"For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation training and access to facilities, qualified staff, and advanced technology that make practicing walking at home difficult. For this reason, developing training approaches that could be easily performed in the home would be of great value. In addition, non-invasive brain…","s":"Completed","tr":["Functional Electrical Stimulation (FES)","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Motor Function","Spasticity","Trunk Control","Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03237234"},{"n":"NCT03237091","t":"Enhancing Corticospinal Excitability to Improve Functional Recovery","d":"Research indicates that increasing brain excitability might help improve hand function in people with spinal cord injury. Brain stimulation that uses electrodes placed on the surface of the scalp (also called \"non-invasive brain stimulation\") increases brain excitability and has the potential to make it easier for the brain and nervous system to respond to arm and hand training. The purpose of this study is to compare four different types of stimulation for increasing brain excitability to…","s":"Completed","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Hand Movement","Motor Function","Plasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03237091"},{"n":"NCT00434018","t":"Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI)","d":"We propose to test an evidence-based wheelchair skills training program to optimize wheelchair safety and performance in veterans with SCI. The proposed training program incorporates emerging evidence on wheelchair biomechanics and motor-skills learning, and addresses recommendations in a new clinical practice guideline. Given the difficulty in translating wheelchair skills learned in a therapy clinic with \"real world\" problems in the home and community post-discharge, we are proposing to…","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Florida","Georgia","Massachusetts"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00434018"},{"n":"NCT02833935","t":"Enhancing Quality of Life Through Exercise: A Tele-Rehabilitation Approach","d":"Pilot randomized controlled trial evaluating a Self-Determination Theory (SDT) video-based tele-rehabilitation physical activity intervention aimed to enhance basic psychological needs, motivation, physical activity (PA), and quality of life- related outcomes of adults with spinal cord injury (SCI). It is anticipated that the individuals who receive the physical activity intervention (intervention group) will have moderate increases in their basic psychological needs, autonomous motivation…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02833935"},{"n":"NCT03320759","t":"Enhancing Recovery in Non-Traumatic Spinal Cord Injury","d":"The investigators have spent the last decade uncovering unique metabolic and functional abnormalities in the brains of patients with spinal cord compression. Degenerative spinal cord compression represents a unique model of reversible spinal cord injury. In the investigator's previous work, they have demonstrated that cortical reorganization and recruitment is associated with metabolic changes in the brains of patients recovering from spinal cord compression and is correlated with recovery and…","s":"Unknown","tr":["Rehabilitation","Surgical Procedure"],"o":["Hand Movement","Motor Function","Plasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03320759","su":"https://scitrials.org/trial/NCT03320759"},{"n":"NCT07364773","t":"Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing","d":"The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI/D) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are trained in a counseling style called motivational interviewing. We want to answer the following questions: 1. Do inpatients with SCI/D treated by physical therapists (PTs) and occupational therapists (OTs) who receive MI training and coaching demonstrate greater therapy…","s":"Recruiting","tr":["Rehabilitation"],"o":["Mental Health"],"st":["Illinois","Texas","Washington"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT07364773","su":"https://scitrials.org/trial/NCT07364773"},{"n":"NCT02392052","t":"Enhancing Self-Efficacy for Caregivers of Family Members With Spinal Cord Injury","d":"Spinal cord injury (SCI) may result in physical deficits that require assistance from others in order to stay healthy and live independently in a community. The assistance provided by caregivers to a family member with SCI often involves a wide range of activities from helping with basic activities, like toileting and bathing, to managing more complex tasks, such as keeping up with household finances, shopping, and transportation. Caregiving puts demands on an individual's ability to cope and…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02392052"},{"n":"NCT02701777","t":"Enhancing STDP After Spinal Cord Injury","d":"The overall goal is to develop new clinical approaches to restore limb function after spinal cord injury (SCI). Corticospinal tract (CST) axons are involved in controlling limb function. Paired pulse induced spike-timing dependent plasticity (STDP) enhances synaptic strength between residual CST axons and spinal motoneurons (SMNs) resulting in temporary improvements in limb function in humans with incomplete SCI. Motor training will be combined with paired-pulse STDP stimulation to further…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Motor Function","Plasticity","Quality of Life","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02701777"},{"n":"NCT00610974","t":"Enhancing Walking in People With Incomplete Spinal Cord Injury: a Pilot Study","d":"The research proposed here will determine the effect of a novel treadmill gait training strategy using a robotic gait trainer (the Lokomat) on functional ambulation in people with SCI. The effect of the new therapy will be evaluated by analyzing changes in functional ambulation and gait patterns during walking.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00610974"},{"n":"NCT02339233","t":"Epi Stim to Facilitate Standing and Stepping","d":"The overall aim is to assess whether task specific locomotor training and spinal cord electrical stimulation (SCES) can induce neural reorganization of the functionally isolated human spinal cord to improve standing and stepping in individuals with functionally complete SCI. The investigators propose that locomotor training will result in generation of more effective standing and stepping efferent patterns by restoring phase dependent modulation of reflexes and reciprocal inhibition, reducing…","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Rehabilitation"],"o":["Leg Movement","Quality of Life","Walking Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02339233"},{"n":"NCT00119522","t":"Epidemiology and Cost of Falls in Veterans With a Spinal Cord Injury","d":"Brief Summary Detailed Description Background: A multitude of risk factors for falling has been reported for the elderly, however many of these risk factors are not applicable to persons with a spinal cord injury, who use a wheelchair for mobility. The objectives of this study are to: (1) describe the incidence and prevalence of tips, falls, and fall-related injuries in SCI; (2) describe the epidemiology of the fall event (person, time, place, and activity); (3) describe any injuries associated…","s":"Completed","tr":["Observational"],"o":[],"st":["Florida","Georgia","Massachusetts"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00119522"},{"n":"NCT04736849","t":"Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury","d":"A study to compare electrophysiologic activity of epidural stimulation and dorsal root ganglion stimulation, as well as quantify changes in motor performance with both types of stimulation over the course of 10 rehabilitation sessions.","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Bladder Function","Bowel Function","Sexual Function","Spasticity"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04736849"},{"n":"NCT03103516","t":"Epidural Decompression Surgery Within 24 Hours After Acute Spinal Cord Injury Improves Spinal Nerve Function","d":"To compare the effects of early (within 24 hours) and delayed (exceed 24 hours) epidural decompression surgery on the recovery of spinal nerve function in patients with acute spinal cord injury (complete and incomplete) at postoperative 6 months.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["China"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03103516","su":"https://scitrials.org/trial/NCT03103516"},{"n":"NCT06455137","t":"Epidural Electrical Stimulation for Spinal Cord Injury Patients and Corticospinal Motor Circuit Improvement","d":"The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06455137","su":"https://scitrials.org/trial/NCT06455137"},{"n":"NCT07105878","t":"Epidural Electrical Stimulation in Spinal Cord Injury","d":"The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) in motor and sensory function Reconstruction in chronic spinal cord injury (SCI) patients classified as ASIA B-D. The main questions it aims to answer are: Does EES treatment significantly improve motor and sensory function in patients with SCI compared to baseline? Is EES a safe intervention for this patient population? Researchers will compare participants' motor function…","s":"Recruiting","tr":["Electrical Stimulation"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07105878","su":"https://scitrials.org/trial/NCT07105878"},{"n":"NCT07207798","t":"Epidural Electrical Stimulation in Spinal Cord Injury (T11-L3)","d":"The primary objective of this clinical trial is to investigate the efficacy of Epidural Electrical Stimulation (EES) in restoring motor and sensory function in patients with chronic spinal cord injury (SCI) at levels T11-L3, classified as ASIA B-D. The study aims to address the following key questions: Does EES lead to significant improvement in motor and sensory function compared to baseline in this patient population? To assess the longitudinal effects of EES, researchers will compare…","s":"Recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07207798","su":"https://scitrials.org/trial/NCT07207798"},{"n":"NCT05111093","t":"Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury","d":"The HemON study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to improve hemodynamic management and trunk control in people with sub-acute or chronic spinal cord injury (\\>= 1 month post injury) between C3 and T6 inclusive, who suffer from orthostatic hypotension.","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05111093","su":"https://scitrials.org/trial/NCT05111093"},{"n":"NCT06847295","t":"Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation","d":"Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence. Despite advances in rehabilitation therapies, many individuals with SCI remain unable to stand or walk. Epidural electrical stimulation (EES) has emerged as a promising neuromodulation therapy to restore motor function in individuals with chronic paralysis. This prospective clinical study aims to evaluate the efficacy and safety of EES…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06847295","su":"https://scitrials.org/trial/NCT06847295"},{"n":"NCT07722130","t":"Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI","d":"This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure. Participants receive ESCES plus standard care; electrodes are implanted at C3-C5 with daily individualized stimulation. Primary outcomes: Edi peak, change of Edi peak and frequency. Secondary: tidal volume, maximal inspiratory pressure, NVE, NME, diaphragm ultrasound, cough strength, 90-day ventilator-free days, ICU stay, and survival…","s":"Recruiting","tr":["Electrical Stimulation","Epidural Stimulation"],"o":["Breathing Function","Motor Function"],"st":[],"co":["China"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07722130"},{"n":"NCT07306052","t":"Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury","d":"The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) combined with rehabilitation training for the reconstruction of walking in patients with chronic spinal cord injury (SCI) classified as AIS B-D. The main questions it aims to answer are: Does the intervention of EES combined with rehabilitation significantly improve walking capacity? Is the combined intervention a safe approach for this patient population? Researchers will…","s":"Recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07306052","su":"https://scitrials.org/trial/NCT07306052"},{"n":"NCT03026816","t":"Epidural Stimulation After Neurologic Damage","d":"This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement. The study will also characterize improvement in autonomic function (such as blood pressure control) and other functions related to spinal cord injury.","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03026816","su":"https://scitrials.org/trial/NCT03026816"},{"n":"NCT05705453","t":"Epidural Stimulation After Neurologic Damage: Long-Term Outcomes","d":"This study will evaluate the long-term effect of chronic spinal cord stimulation to restore volitional movement for patients with chronic spinal cord injuries.","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05705453","su":"https://scitrials.org/trial/NCT05705453"},{"n":"NCT04105296","t":"Epidural Stimulation After Spinal Cord Injury","d":"The purpose of the current study is to determine the effects of applying epidural stimulation (ES) on motor control recovery in Veterans with SCI. The intervention will be accompanied with the use of a powered exoskeleton (EKSO®) for 6 months to facilitate standing and to produce step-like movement in persons with chronic motor complete (AIS A or B) SCI and level of injury below C5 . Walking speed, distance, muscle activation pattern as measured by surface EMG and walking parameters including…","s":"Unknown","tr":["Epidural Stimulation","Exoskeleton"],"o":["Walking Function"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04105296","su":"https://scitrials.org/trial/NCT04105296"},{"n":"NCT07717606","t":"Epidural Stimulation and Rehabilitation for Spinal Cord Injury","d":"Spinal cord injury involving the conus region often results in severe impairments in mobility, self-care, and bladder and bowel function, substantially reducing independence and quality of life. Epidural electrical stimulation (EES), combined with structured rehabilitation, has emerged as a promising neuromodulation strategy for improving functional recovery; however, evidence in patients with conus-region involvement remains limited. This exploratory cohort study aims to evaluate functional…","s":"Completed","tr":["Devices","Electrical Stimulation","Epidural Stimulation","Observational","Rehabilitation"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07717606"},{"n":"NCT04782947","t":"Epidural Stimulation and Resistance Training After SCI","d":"Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life. A new scientific breakthrough called \"lumbosacral epidural stimulation\" or \"ES\" can help people with SCI to stand, step and even walk again. At present, for ES to work, people must train with a specialized treadmill that requires several other qualified personnel to train them, which makes it…","s":"Recruiting","tr":["Epidural Stimulation","Exoskeleton"],"o":["Walking Function"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04782947","su":"https://scitrials.org/trial/NCT04782947"},{"n":"NCT06437548","t":"Epidural Stimulation for Upper Extremity Function","d":"Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life. At present, there are limited options for hand or arm reanimation in this patient population. Nerve transfer is one such option that can partially restore the natural movement of hand or arm function in select patients. The investigators are interested in understanding whether recovery of hand or arm motor function after nerve transfer can be…","s":"Not yet recruiting","tr":["Epidural Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06437548","su":"https://scitrials.org/trial/NCT06437548"},{"n":"NCT05690074","t":"Epidural Stimulation in Chronic Spinal Cord Injury Patients","d":"Investigators propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular, urinary and sexual function as well as the ability to voluntarily control leg movements below the injury level. This intervention would provide an immediate therapeutic alternative to individuals who now have no recourse for treatment. In addition investigators suggest to prove on functional magnetic resonance imaging if there are some significant…","s":"Unknown","tr":["Epidural Stimulation"],"o":["Bladder Function","Sexual Function"],"st":[],"co":["Czechia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05690074","su":"https://scitrials.org/trial/NCT05690074"},{"n":"NCT05966896","t":"Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury","d":"This proof-of-concept case series will prospectively use magnetic resonance imaging (MRI) evidence of spared spinal cord neural fibers to guide the selection of 2 research participants to receive a surgically implanted epidural stimulator with the goal of restoring voluntary movement after spinal cord injury (SCI). Because MRI evidence of spared spinal cord neural fibers demonstrated significant relationships with responsiveness to epidural stimulation in SCI in retrospective studies, the…","s":"Enrolling by invitation","tr":["Epidural Stimulation"],"o":[],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05966896","su":"https://scitrials.org/trial/NCT05966896"},{"n":"NCT04925882","t":"Erector Spinae Plane Block in Lumbar Release Surgery","d":"The aim of this study is to observe or not a reduction in the consumption of morphine within 72 hours of the realization of an erector spinae plane block when preparing for a non-instrumented spine surgery.","s":"Completed","tr":["Surgical Procedure"],"o":["Pain Management","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04925882"},{"n":"NCT02268266","t":"ERIGO® Life- Control of Cardiovascular Parameters Via Verticalization and Simultaneous Mobilization","d":"Early verticalization and stepping with the equipment of Hocoma ERIGO during monitoring of vital parameters. The device is already CE marked and, for the purposes of the study, will be used in accordance with the intended use (after-market clinical investigation).","s":"Completed","tr":["Devices","Safety"],"o":["Blood Pressure","Walking Function"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02268266"},{"n":"NCT05109819","t":"Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.","d":"Metastatic spinal cord compression (MSCC) is a serious complication to metastatic cancer and when diagnosed life expectancy is short. Treatment is palliative radiotherapy (RT). Early esophageal toxicity is underreported but can seriously impact quality of life (QoL). The aim of the ESO-SPARE trial is to investigate if esophagus sparing RT can decrease patient reported esophageal toxicity without compromising ambulatory function or increase other toxicities. 200 patients with MSCC in the…","s":"Unknown","tr":[],"o":["Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Denmark"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05109819"},{"n":"NCT05910593","t":"Establishing the Validity and Reliability of a Dexterity Assessment Tool","d":"Every year, thousands of Canadians are diagnosed with degenerative cervical myelopathy (DCM), a form of non-traumatic injury caused by spinal cord compression in the neck. While DCM causes a range of symptoms, one of the most disabling is loss of hand dexterity. Surgical decompression is standard treatment for DCM, but reduced dexterity often remains. The investigators have developed a portable, easy-to-use dexterity assessment tool for measuring hand dexterity. Hand function is often assessed…","s":"Unknown","tr":["Observational","Surgical Procedure"],"o":["Hand Movement","Motor Function","Sensory Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05910593"},{"n":"NCT04319679","t":"ESWT for UE Pain in Patients With Cervical Spinal Cord Injury","d":"This study aimed to investigate the efficacy and safety of extracorporeal shockwave therapy (ESWT) for upper extremity pain related to spasticity in patients with spinal cord injury.","s":"Terminated","tr":["Devices"],"o":["Arm Movement","Hand Movement","Pain Management","Spasticity"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04319679"},{"n":"NCT02315339","t":"European Home Mechanical Ventilation Registry","d":"The European Home Mechanical Ventilation Registry (EHMVR) will enable a thorough evaluation of HMV by documenting the characteristics of HMV patients and their treatment. This will facilitate a prospective, observational study to identify the primary indications for HMV, describe patterns of HMV use in European countries, and characterize changes in the initiation and utilization of HMV over time. The registry will target all adult individuals who have an indication for HMV. In the EHMVR…","s":"Terminated","tr":["Observational"],"o":["Breathing Function","Mental Health","Quality of Life","Walking Function"],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02315339"},{"n":"NCT01571531","t":"European Multicentre Study of Human Spinal Cord Injury","d":"Today there is accumulating evidence from animal experiments that regeneration can be induced after a spinal cord injury (SCI). Consequently in the near future, new therapeutic approaches to induce some regeneration will be included in the treatment of patients with SCI. The aim of this proposal is to provide the required clinical basis for the implementation of novel interventional therapies. The establishment of combined clinical, functional and neurophysiological measures for a qualitative…","s":"Recruiting","tr":["Safety"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01571531","su":"https://scitrials.org/trial/NCT01571531"},{"n":"NCT04165395","t":"Evaluate the Incidence of Sacral and Heel Pressure Ulcers During Acute Care After SCI","d":"This study evaluates the effect of the application of a five-layer foam dressing on the sacrum as well as a boot applied on the heels as preventive measures in the development of pressure ulcers in patients hospitalized with spinal cord injury. In order to study their effectiveness in preventing wounds, we will compare the number of wounds that developed on the sacrum and heels in participants with and without preventive treatments. The study will also assess the severity of pressure ulcers in…","s":"Unknown","tr":[],"o":["Pressure Sores"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04165395","su":"https://scitrials.org/trial/NCT04165395"},{"n":"NCT01961557","t":"Evaluating a New Knee-Ankle-Foot Brace to Improve Gait in Children With Movement Disorders","d":"Background: \\- Cerebral palsy (CP) is the most common motor disorder in children. CP often causes crouch gait, an abnormal way of walking. Knee crouch has many causes, so no single device or approach works best for everybody. This study s adjustable brace provides many types of walking assistance. Researchers will evaluate brace options to find the best solution for each participant, and whether one solution works best for the group. Objective: \\- To evaluate a new brace to improve crouch gait…","s":"Completed","tr":["Devices","Electrical Stimulation"],"o":["Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01961557"},{"n":"NCT05726591","t":"Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders","d":"Background: People with cerebral palsy, spina bifida, muscular dystrophy, or spinal cord injury often have muscle weakness and problems controlling how their legs move. This can affect how they walk. The NIH has designed a robotic device (exoskeleton) that can be worn on the legs while walking. The wearable robot offers a new form of gait training. Objective: To learn whether a robotic device worn on the legs can improve walking ability in those with a gait disorder. Eligibility: People aged 3…","s":"Recruiting","tr":["Exoskeleton"],"o":[],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05726591","su":"https://scitrials.org/trial/NCT05726591"},{"n":"NCT03385005","t":"Evaluating Neuromuscular Stimulation for Restoring Hand Movements","d":"The specific aim of this study is to evoke functional movement in the hand of both healthy individuals and individuals diagnosed with a stable cervical spinal cord injury with non-functional movement of the fingers. The primary purpose of this study is to determine the feasibility of achieving refined hand movements through electrical stimulation of the muscles within the forearm. It is believed that this study will be able to identify specific stimulation parameters and electrode spatial…","s":"Completed","tr":["Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)","Rehabilitation","Transcutaneous Stimulation"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03385005"},{"n":"NCT06520020","t":"Evaluating Safety and Feasibility of Transcutaneous Spinal Cord Stimulation Following Traumatic and Non-Traumatic Spinal Cord Injury: A Pilot Study","d":"The study will be a non-randomized, non-blinded pilot study to analyze the safety and feasibility of a non-significant risk device, transcutaneous spinal cord stimulation. The aim is to include 30 total patients, 10 patients in each of 3 groups: 1. Non-traumatic spinal cord injury (ntSCI) with diagnosis of degenerative cervical myelopathy and offered surgical intervention. 2. Early tSCI screened during the hospital admission when cervical/thoracic spinal injury was diagnosed. 3. Delayed tSCI…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06520020","su":"https://scitrials.org/trial/NCT06520020"},{"n":"NCT00654680","t":"Evaluating the Efficacy and Safety of Vardenafil in Patients Erectile Dysfunction Solely Secondary to Spinal Cord Injury","d":"Investigate efficacy and safety of Vardenafil in patients with spinal cord injury","s":"Completed","tr":["Drugs","Safety"],"o":["Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00654680"},{"n":"NCT01920243","t":"Evaluation of a Bowel and Bladder Health Management Program for Individuals With Spinal Cord Injury (SCI)","d":"This study will look at the use of a telehealth version of a self management program in individuals with both new onset and chronic traumatic spinal cord injuries. The program is called Health Mechanics. It is meant to enhance self management skills related to neurogenic bladder and bowel management to prevent associated problems and improve Quality of Life (QOL). This program is based on the needs and strengths of individuals with SCI. It focuses on enhancing skills, encouraging positive…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01920243"},{"n":"NCT06708026","t":"Evaluation of a Home-based AOMI Intervention on Cognitive Function and Depression Among Adults with SCI","d":"The investigators propose a pilot randomized clinical trial to determine if adults with spinal cord injury (SCI) show improved cognitive function and depression following home-based Action Observation and Motor Imagery (AOMI) training. It is hypothesized that the home-based AOMI intervention will show satisfactory feasibility and acceptability. They also hypothesize that AOMI training can be used as a rehabilitative tool for improving cognitive function and depression in adults with SCI…","s":"Not yet recruiting","tr":[],"o":["Mental Health"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06708026","su":"https://scitrials.org/trial/NCT06708026"},{"n":"NCT03171207","t":"Evaluation of a Novel Gait Training Device to Support Body Weight","d":"A novel body weight support device that uses pressurized pants may provide advantages in delivering gait therapy. The objectives of this study are to test the following hypotheses that 1) the novel device will allow for increased body weight support while improving or maintaining the same level of patient comfort; 2) the novel device will yield greater patient satisfaction with gait therapy relative to current harness systems; 3) therapists will be more satisfied with the use of the novel…","s":"Unknown","tr":["Devices","Rehabilitation"],"o":["Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03171207","su":"https://scitrials.org/trial/NCT03171207"},{"n":"NCT02656927","t":"Evaluation of a Specialized Yoga Program for Persons With Spinal Cord Injury (SCI)","d":"The purpose of this randomized controlled study is to evaluate psychological variables, mindfulness, and pain in the context of a specialized yoga program for individuals with SCI. Participants will be randomized to either a wait-list control condition or to a specialized yoga program condition.","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02656927"},{"n":"NCT01124292","t":"Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis","d":"This study was intended to evaluate a new assistive neuro-technology, known as the Tongue Drive System (TDS), by its potential end-users, i.e. individuals with severe disabilities, who are the best experts for indicating the benefits and possible shortcomings of any new ANT. Our goal is to assess the acceptability and usability of the TDS for various tasks that are important in daily lives of these individuals, such as computer access, wheeled mobility, and environmental control.","s":"Completed","tr":["Devices"],"o":[],"st":["Georgia","Illinois"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01124292"},{"n":"NCT00623389","t":"Evaluation of an Advanced Lower Extremity Neuroprostheses","d":"The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":["Ohio"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT00623389","su":"https://scitrials.org/trial/NCT00623389"},{"n":"NCT05095506","t":"Evaluation of an eHealth System to Reduce Depression and Increase Resilience After SCI","d":"The availability of symptom monitoring and self-management (SMSM) interventions is especially important for civilians and military populations with spinal cord injuries (SCI). High rates of depressive disorders (20-40%) and anxiety disorders (20-25%) have been found in both civilian and military populations and are significant contributors to both quality of life and well-being after SCI. Previous self-management interventions targeting physical activity and self-reliance in individuals with…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Delaware"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05095506"},{"n":"NCT02152657","t":"Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study","d":"The purpose of this study is to analyze the safety and efficacy of mesenchymal stem cell transplantation through percutaneous injection in patients with chronic spinal cord injury.","s":"Completed","tr":["Stem Cells"],"o":["Motor Function","Pain Management"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02152657"},{"n":"NCT05744271","t":"Evaluation of FES+VFBT With Individuals With Lived Experience","d":"Falls are a concern for people living with spinal cord injury (SCI) or stroke. Falls may result in injury and a fear of falling, which often cause people to restrict their mobility and daily activities. Despite its importance, fall prevention for people with SCI or stroke has not been studied in detail, and as a result, there is a lack of treatments to address their high fall risk. Functional electrical stimulation (FES) is the application of a mild electrical stimulus to a muscle that helps it…","s":"Completed","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Leg Movement","Motor Function","Plasticity","Sensory Function","Trunk Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05744271"},{"n":"NCT04256603","t":"Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI","d":"Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial. There is evidence to support that gabapentin and pregabalin have some benefit in reducing neuropathic pain. Gabapentin is effective in the management of symptoms and concerns related to SCI including motor recovery, spasticity, and mood among others. This makes gabapentin an important…","s":"Completed","tr":["Drugs"],"o":["Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04256603"},{"n":"NCT04906928","t":"Evaluation of New MRI Sequences Including 3D-FGAPSIR for the Optimization of Inflammatory Spinal Cord Lesions Research","d":"* verification of inclusion and non-inclusion criteria * information and collection of consent * standard imaging protocol prescribed as part of the usual treatment: sagittal T1 and T2 slices after injection of contrast product (Gadolinium), 3D STIR and 3D PSIR sequence. * 3D FGAPSIR sequence at the level of the cervical cord for the duration of the additional sequence is 10 minutes, for a total examination time of 40 minutes (instead of 30 minutes)","s":"Recruiting","tr":["Devices","Drugs","Observational"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04906928"},{"n":"NCT02506712","t":"Evaluation of Physiological and Biomechanical Efficiency of the PAPAW","d":"The main objective is to quantify energy expenditure when using the SmartDrive system during manual wheelchair propulsion in external conditions (slope, straight line). For this two comparisons are performed: Comparison of energy expenditure with and without the use of a system SmartDrive 6 minute propulsion test. Comparison the risk of musculoskeletal disorders of the wrist during a 6 minute propulsion test.","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02506712"},{"n":"NCT03477123","t":"Evaluation of Robotic Exoskeletons Therapy for Gait Rehabilitation in Patients With Incomplete Spinal Cord Injury.","d":"The objective of the study is to assess the efficacy of the Exo-H2 robotic exoskeleton for walking rehabilitation of people with incomplete spinal cord injury.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03477123"},{"n":"NCT04597931","t":"Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density","d":"This is a randomized study to determine the effects of monthly romosozumab for one year or one-time zoledronic acid on bone mineral density (BMD) and biochemical markers of bone formation and resorption, in patients with spinal cord injury (SCI) and low BMD.","s":"Unknown","tr":[],"o":["Bone Strength"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04597931","su":"https://scitrials.org/trial/NCT04597931"},{"n":"NCT04110561","t":"Evaluation of Safety and Performance of the Atalante System With Patients With Lower Limb Paralysis","d":"The study is a prospective, open, bicentric and observational study. It is conducted to assess the safety and performance of the Atalante exoskeleton system with patients with lower limb paralysis. The principal objective is to assess the performance of the Atalante system in performing ambulatory functions with motor complete SCI patients characterized by the success rate in performing a 10mWT at the last session of training with the Atalante system.","s":"Completed","tr":["Exoskeleton"],"o":["Bladder Function","Leg Movement","Pain Management","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["France"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04110561"},{"n":"NCT03031223","t":"Evaluation of Sensory-motor Response to Low-level Laser Therapy for the Treatment of Spinal Injuries","d":"Spinal cord injuries have become increasingly frequent due mainly to the increase in urban violence. The growing number of automobile collisions and violence-related events merits particular attention, as such occurrences can lead to death or disability stemming from a spinal injury. The severity of the consequences depends on the location affected and degree of destruction of afferent and efferent spinal cord pathways, with higher, more extensive injuries leading to less physical fitness and…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":[],"st":[],"co":["Brazil"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03031223","su":"https://scitrials.org/trial/NCT03031223"},{"n":"NCT04523636","t":"Evaluation of Splinting in Tetraplegia","d":"This study compared pre-fabricated and custom resting hand splints among people who were in inpatient rehabilitation after a cervical spinal cord injury.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Hand Movement","Motor Function","Sensory Function"],"st":["Maryland","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04523636"},{"n":"NCT04316195","t":"Evaluation of the Bulbocavernosus Reflex After Acute Spinal Cord Injury","d":"The purpose of this study is to evaluate the possibility to use electromyography in acute phase after a traumatic spinal cord injury to measure quantitatively and objectively the bulbocavernosus reflex. This study also aims to determine if there is a relationship between the bulbocavernosus reflex and neuro-functional recovery 3 months after a traumatic spinal cord injury. To do so, 20 patients admitted for acute traumatic spinal cord injury will be recruited prospectively. Within 72 hours…","s":"Unknown","tr":["Observational","Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04316195","su":"https://scitrials.org/trial/NCT04316195"},{"n":"NCT03452059","t":"Evaluation of the Effectiveness and Safety of AI-Robotics","d":"Evaluation of the effectiveness and safety of the lower extremity exoskeleton rehabilitation training robot","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Blood Pressure","Leg Movement","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03452059"},{"n":"NCT01953666","t":"Evaluation of the Efficiency of Word Prediction Software to Text Input Speed for Tetraplegia","d":"Computers now play an important role in the lives of most individuals.Access to computers is crucial for people with disabilities and may improve their quality of life. The use of computers can facilitate mainstreaming at school, for example, and the Internet may provide a valuable means of communication. However, the use of computers requires a certain degree of motor ability. People with motor disabilities frequently experience difficulties using a standard keyboard and standard pointing…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Sensory Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01953666"},{"n":"NCT03898258","t":"Evaluation of the German Short-Form Qualiveen Questionnaire","d":"Two questionnaires (Qualiveen full version and Qualiveen short-form (SF)), the project information and the consent form will be sent to individuals who are scheduled for an annual control at the urological out-patient clinic of the Swiss Paraplegic Centre and who fulfill the inclusion criteria. The patients will be asked to complete the two questionnaires and to bring the completed questionnaires and the signed consent form to the annual control at the Swiss Paraplegic Centre. Participants who…","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03898258"},{"n":"NCT07616050","t":"Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients","d":"The purpose of this clinical study is to evaluate the feasibility, usability, and motivational impact of VirtualPark, a virtual reality-based dual-task rehabilitation system, in adults with neurological and age-related conditions. VirtualPark is a virtual reality application designed to deliver cognitive exercises during cycling training using a commercially available ergometer (THERA-Trainer Tigo). The system integrates physical and cognitive tasks in simulated real-life environments. The…","s":"Not yet recruiting","tr":["Devices","Rehabilitation"],"o":[],"st":[],"co":["Italy"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07616050"},{"n":"NCT01188447","t":"Evaluation of the Safety of C-Spine Clearance by Paramedics","d":"The goal of this cohort study is to evaluate the safety and potential impact of an active strategy that allows paramedics to assess very low-risk trauma patients with the Canadian C-Spine Rule (CCR) and transport them to the Emergency Department without immobilization. The specific objectives of the study are to determine safety, determine the clinical impact and evaluate performance.","s":"Completed","tr":[],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01188447"},{"n":"NCT07131553","t":"Evaluation of the Wheelchair School (Drivkraft) a Clinical Study","d":"This project will evaluate the Wheelchair School with the Drivkraft Methodology in a clinical setting. Participants are adults with chronic neurological diagnoses. For a person requiring a wheelchair, a well-functioning, individually adapted wheelchair and good maneuvering skills are essential for an independent daily life. These factors are also crucial in reducing the risk of secondary complications and pain. The Wheelchair School was founded in the 1990s, is provided by referral and both…","s":"Not yet recruiting","tr":["Devices"],"o":[],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07131553","su":"https://scitrials.org/trial/NCT07131553"},{"n":"NCT00561067","t":"Evaluation of Tolerability and Efficacy of Erythropoietin (EPO) Treatment in Spinal Shock: Comparative Study Versus Methylprednisolone (MP)","d":"The purpose of this study is to evaluate the tolerability and efficacy of erythropoietin (EPO) treatment in spinal shock in comparison with the methylprednisolone treatment (MP).","s":"Terminated","tr":["Drugs"],"o":["Motor Function","Pain Management","Spasticity"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00561067"},{"n":"NCT06939634","t":"Evaluation of Usability and Safety of the System Atalante in Patients With High Paraplegia and Tetraplegia","d":"The objective of this clinical trial is to determine whether the Atalante X exoskeleton can be safely utilized by patients with tetraplegia and high paraplegia (at or above T4).","s":"Completed","tr":["Devices","Exoskeleton","Observational"],"o":["Spasticity","Trunk Control","Walking Function"],"st":[],"co":["France"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06939634"},{"n":"NCT04323449","t":"Evaluation of Vision-Guided Shared Control for Assistive Robotics Manipulators","d":"The purpose of this study is to evaluate a new control (i.e., the vision-guided shared (VGS) control) for a wheelchair-mounted assistive robotic manipulator among powered wheelchair users. This study consists of a questionnaire about general demographics, health information, and previous experience with assistive technology. Several tests are also administered to test upper extremity function and ability as well as to test spatial orientation and visualization ability. Participants till then…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Quality of Life"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04323449"},{"n":"NCT07669181","t":"Examination of the Role of Human Exoskeletons in Rehabilitation","d":"Background and Rationale: Traumatic spinal cord injury (SCI) affects approximately 12,400 individuals annually in the USA, predominantly impacting healthy young adults aged 20-40 years. Complete SCI above the lumbar region results in paraplegia or tetraplegia, severely compromising quality of life. Wheelchair-dependent lifestyle and immobilization lead to serious secondary complications including osteoporosis, diabetes mellitus, atherosclerosis, pressure ulcers, depression, and pathological…","s":"Active, not recruiting","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Bone Strength","Bowel Function","Leg Movement","Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Hungary"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07669181"},{"n":"NCT06007885","t":"Examining Capacity Building of Youth With Physical Disabilities to Pursue Participation Following the PREP Intervention.","d":"The goal of this clinical trial is to learn about how a participation-based intervention builds capacity of youth with physical disabilities to pursue activities of their choice in the community. The investigators plan to examine in what ways working with a therapist to set up and engage in an 8-week self-chosen community-based activity builds capacity of youth with physical disabilities to pursue a new activity of their choice in the community without the support of a therapist. During this…","s":"Unknown","tr":[],"o":["Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06007885"},{"n":"NCT03319225","t":"Examining the Distal Gut Microbiome After Spinal Cord Injury","d":"The purpose of this research study is to learn more about the causes of gastrointestinal dysfunction after spinal cord injury. It has been thought that the microbiome (the community of bacteria in the body) may be one such cause. The study will examine whether changes in the distal gut microbiome are related to gastrointestinal dysfunction in persons with Spinal Cord Injury and Non-Disabled Controls.","s":"Completed","tr":["Observational"],"o":["Bowel Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03319225"},{"n":"NCT06906536","t":"Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function","d":"The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.","s":"Enrolling by invitation","tr":["Intermittent Hypoxia","Rehabilitation"],"o":["Regeneration"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06906536","su":"https://scitrials.org/trial/NCT06906536"},{"n":"NCT06850363","t":"ExaStim Upper Limb Home Use Clinical Validation Study","d":"This is a multi-center, observational, single-arm, 6-week home study to evaluate the safety and efficacy of transcutaneous spinal cord stimulation via the ExaStim system for 4 consecutive weeks used in the home setting for individuals with traumatic spinal cord injury. The study consists of a baseline evaluation and 1-week training period (Week 0), a 4-week stimulation period (Weeks 1-4), and a follow-up visit (Week 5), for a total expected duration of participation for each subject of six…","s":"Completed","tr":["Devices","Electrical Stimulation","Transcutaneous Stimulation"],"o":["Arm Movement","Mental Health","Motor Function","Quality of Life"],"st":["Colorado","Illinois","Maryland","Massachusetts","Wisconsin"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06850363"},{"n":"NCT04887688","t":"Exciflex Electroceutical Banadage for Chronic Wound Therapy","d":"Objectives: The study objective is to carry a pilot clinical assessment comparing the exciflex bandage to standard of care (SoC) for ischemic wounds and will involve participants who are Veterans with lower extremity ischemic wounds. Research Plan: The study will employ a randomized repeated measures design to assess the therapeutic effectiveness of exciflex in clinical use. Methodology: All participants with chronic ischemic wounds treated at Louis Stokes Cleveland VA Medical Center (LSCDVAMC)…","s":"Recruiting","tr":[],"o":["Pressure Sores"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04887688","su":"https://scitrials.org/trial/NCT04887688"},{"n":"NCT04007445","t":"Exercise for People with Spinal Cord Injury","d":"The purpose of the study is to examine the impact of a transitional exercise intervention implemented in the community for people with SCI on psychological well-being, social factors, and physiological health.","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04007445"},{"n":"NCT06524453","t":"Exercise Program for Individuals With SCI in Community","d":"Patients with spinal cord injury (SCI) who have reduced mobility have difficulty exercising on their own without proper guidance in the community. Community-based exercise programs are effective in removing various barriers such as lack of exercise programs, lack of experts, and lack of facilities. This study aims to verify the effectiveness and safety of a systematically designed customized exercise program for patients who live in the community and want to participate in exercise. Our study…","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06524453","su":"https://scitrials.org/trial/NCT06524453"},{"n":"NCT00204126","t":"Exercise Testing During Treadmill Gait in Incomplete Spinal Cord Injury","d":"Treadmill therapy has the potential to improve the physical fitness and voluntary function of incomplete-lesion spinal cord injured (SCI) patients. However, if it is to be offered as a rehabilitation strategy, evidence must be gathered to support its effectiveness. Present methods used to determine the efficacy of treadmill training do not provide accurate means of monitoring changes in physical fitness during the exercise, or to accurately measure the changes in voluntary muscle function which…","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00204126","su":"https://scitrials.org/trial/NCT00204126"},{"n":"NCT00270855","t":"Exercise to Reduce Obesity in Spinal Cord Injury","d":"The purpose of this proposal was to evaluate and compare the health benefits of using upper extremity exercise versus functional electrical stimulation for lower extremity exercise. It was our hypothesis that both Functional Electrical Stimulation Leg Cycle Ergometry (FES LCE) exercise and voluntary Arm Crank Ergometry (ACE) upper extremity exercise would increase whole body energy expenditure, thereby increasing muscle mass, insulin sensitivity, glucose effectiveness and improving lipid…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Bone Strength","Leg Movement"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00270855"},{"n":"NCT03727893","t":"Exercise Training and Manual Wheelchair Users With SCI","d":"The overall purpose of this pilot randomized control trial (RCT) is to determine the efficacy of the high-intensity interval training (HIIT) exercise protocols for the WheelMill System (WMS) to improve exercise intensity, cardiovascular fitness, metabolic health, and psychological well-being in manual wheelchair users (MWUs) with spinal cord injury (SCI).","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Mental Health","Pain Management"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03727893"},{"n":"NCT02235714","t":"Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury","d":"The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers. These markers will be compared in tetraplegic, asthmatic and able-bodied control groups. Additionally, lung function testing will be performed, and the associations between breath condensate and blood markers and pulmonary function explored between groups.","s":"Completed","tr":["Observational"],"o":["Breathing Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02235714"},{"n":"NCT00753948","t":"Exhaled Levels of Nitric Oxide","d":"Previously it was observed that individuals with tetraplegia have reduced baseline airway caliber and exhibit non-specific airway hyperresponsiveness (AHR). In persons with tetraplegia we have suggested that this is due to overriding cholinergic airway tone. In asthma, the mechanisms underlying bronchoconstriction and AHR are more closely tied to airway inflammation. Whether AHR in tetraplegia is also related to chronic airway inflammation is unknown. Recently, a non-invasive technique for…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Breathing Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00753948"},{"n":"NCT04215081","t":"ExoAtlet II For SCI Patients","d":"This study will evaluate the ExoAtlet II exoskeleton for safety and effectiveness of providing persons with a spinal cord injury (SCI) who are non-ambulatory or have limited ambulatory function, to stand up and ambulate under a variety of conditions.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Russia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04215081"},{"n":"NCT07418398","t":"Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.","d":"Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical complications that can devastate quality of life. There is a scarcity of research that has successfully implemented rehabilitation and/or exercise training interventions to preserve the musculoskeletal system during the acute phase SCI, or possibly reverse the muscle and bone…","s":"Not yet recruiting","tr":["Electrical Stimulation","Exoskeleton"],"o":["Bone Strength"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07418398","su":"https://scitrials.org/trial/NCT07418398"},{"n":"NCT04221373","t":"Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation","d":"The purpose of this research study is to test the effect of early exoskeletal-assisted walking (EAW) training (combined into regular acute inpatient rehabilitation (AIR)) on improving functional recovery and reducing pain and inflammation. Powered exoskeletons are a technology that offer standing and walking for certain persons with spinal cord injury (SCI) who meet the using indication of the device and have been used in the chronic SCI population with positive benefits in ability to move…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Bladder Function","Pain Management","Quality of Life","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04221373"},{"n":"NCT02314221","t":"Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI","d":"The primary objective of this study is to achieve successful walking skills using exoskeletal walking devices over the course of 36 sessions in 3 months at specific velocities and distances in people with chronic SCI who are wheelchair dependent for community mobility. The secondary objectives are to determine if this amount of exoskeletal walking is effective in improving bowel function and body composition in the same patient population. The exploratory objectives are to address additional…","s":"Completed","tr":["Exoskeleton"],"o":["Blood Pressure","Bowel Function","Quality of Life","Walking Function"],"st":["Maryland","New Jersey","New York"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02314221"},{"n":"NCT03410550","t":"Exoskeleton and Spinal Cord Injury","d":"The purpose of the current study is to investigate the effects of powered exoskeleton (EKSO) on cardiovascular performance as measured by resting blood pressure and heart rate, peak oxygen consumption during walking, energy expenditure, whole and regional body composition assessments. The effects of exoskeleton training on walking kinematics including stand-up time, walking time, distance covered and speed of walking will also be evaluated.","s":"Completed","tr":["Exoskeleton"],"o":["Blood Pressure","Walking Function"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03410550"},{"n":"NCT03096197","t":"Exoskeleton and Spinal Cord Stimulation for SCI","d":"The overall aim of this project is to assess the effect of combining transcutaneous lumbosacral stimulation (TLS) during Exoskeleton Assisted Walking (EAW) compared to EAW alone without stimulation on walking recovery.","s":"Recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03096197","su":"https://scitrials.org/trial/NCT03096197"},{"n":"NCT05176327","t":"Exoskeleton Neurogenic Bowel Dysfunction Study","d":"The purpose of the study is to assess the effects of exoskeleton training on neurogenic bowel disorders in spinal cord injury/ disease.","s":"Completed","tr":["Exoskeleton"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05176327"},{"n":"NCT07062575","t":"Exoskeleton Training at Home to Assist Participants With Spinal Cord Injuries to Perform Ambulatory Functions.","d":"The goal of this clinical trial is to to confirm the safety and performance of the ABLE Daily to perform ambulatory functions in home and community settings for people with spinal cord injury. The experimental period will cover the training period with the ABLE Daily exoskeleton (3 weeks of use at the investigational site with a total of 9 sessions) and the home period (12 weeks of personal use at home and community environments).","s":"Recruiting","tr":["Exoskeleton"],"o":[],"st":[],"co":["Netherlands"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07062575","su":"https://scitrials.org/trial/NCT07062575"},{"n":"NCT06463418","t":"Exoskeleton Training for Spinal Cord Injury Neuropathic Pain (ExSCIP)","d":"The goal of this feasibility trial is to learn if exoskeleton or robotic walking works to reduce nerve (neuropathic) pain after spinal cord injury. This study asks is: * Providing walking practice through use of a robotic device (exoskeleton) three times per week for twelve weeks possible to deliver? * Would people sign up and stick to the programme? * And will it help to reduce neuropathic pain levels after spinal injury? Researchers will compare robotic walking and a relaxation program to see…","s":"Active, not recruiting","tr":["Exoskeleton"],"o":["Pain Management"],"st":[],"co":["Ireland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06463418","su":"https://scitrials.org/trial/NCT06463418"},{"n":"NCT06971510","t":"Exoskeleton Training on Balance Control and Turning in Ambulation in Individuals With Incomplete Spinal Cord Injury","d":"This study investigates the impact of exoskeleton training on individuals with incomplete spinal cord injury (iSCI). Investigators focus on assessing how the use of the exoskeleton influences balance control and turning during ambulation and quality of life in this population. The study mainly involves interventions with participants utilizing exoskeleton devices to explore the influence on mobility, stability, and neuroplasticity, providing new insights into the potential benefits of…","s":"Active, not recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["China"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06971510","su":"https://scitrials.org/trial/NCT06971510"},{"n":"NCT03144830","t":"Exoskeleton Use in Acute Rehab Post Spinal Cord Injury; a Safety and Feasibility Study","d":"This study will examine the safety and feasibility of using an exoskeleton in subjects who are less than 6 months post spinal cord injury (SCI).","s":"Completed","tr":["Exoskeleton","Safety"],"o":["Pain Management","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03144830"},{"n":"NCT07352085","t":"Exoskeleton-assisted Neurorehabilitation","d":"* Objective assesment of the feasibility of integrating the Ekso Bionics - Ekso NR device into outpatient care * Objective assesment of quality of life, functionality and clinical symptomps of patients with stroke, cerebellar ataxia, spinal cord injury, and spastic paraparesis * Comparison of measured data and follow-up of changes in relation to themselves and each other * Analyzing the effects of the exoskeleton among the patients * Assessing the safety, possible side effects and tolerability…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Hungary"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07352085"},{"n":"NCT04532723","t":"Exoskeleton-Assisted Walking ExoAtlet II","d":"Based on prior exoskeleton research, it was determined that 40 participants of variable height, weight and injury level would provide a significant measure of the safety and feasibility of using the ExoAtlet II in individuals with SCI for standing and walking rehabilitation therapy. Craig Hospital will be responsible for enrolling up to 30 individuals during the study duration.The inclusion criteria will be utilized to identify appropriate subjects for this study.","s":"Withdrawn","tr":["Exoskeleton","Rehabilitation","Safety"],"o":["Blood Pressure","Spasticity","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04532723"},{"n":"NCT04013997","t":"Exoskeleton-assisted Walking in SCI Inpatient Rehabilitation","d":"To assess how safe the exoskeleton, EksoGT, is to use for acute inpatient rehabilitation, if it helps people to walk better than with traditional walking training methods, or if they have any other effects (better or worse) on recovery.","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Arm Movement","Leg Movement","Quality of Life","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04013997"},{"n":"NCT01943669","t":"Exoskeletons for Spinal Cord Injury: A Feasibility Study","d":"In this study, 10 volunteer participants with chronic spinal cord injury will undergo a 10-week training schedule for ambulation with the ReWalk™ device. The ReWalk™ consists of a lightweight brace-support suit containing motors at the hip and knee joints, rechargeable batteries and a computerized control system carried in a backpack. ReWalk™ users control their ambulation through subtle changes in centre of gravity and upper-body movements. Before, during and after training sessions the…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01943669","su":"https://scitrials.org/trial/NCT01943669"},{"n":"NCT04278235","t":"Expanded Access to Elezanumab","d":"This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to Elezanumab prior to approval by the local regulatory agency. Availability will depend on territory eligibility. A medical doctor must decide whether the potential benefit outweighs the risk of receiving an investigational therapy based on the individual patient's medical history and program eligibility criteria.","s":"No longer available","tr":["Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04278235"},{"n":"NCT05267223","t":"Experience of Rehabilitation Amongst Individuals With Paraplegia","d":"This study is a qualitative study exploring the facilitators to physical and vocational rehabilitation and also explores the barriers in empowering individuals with paraplegia","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["India"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05267223","su":"https://scitrials.org/trial/NCT05267223"},{"n":"NCT01652352","t":"Experimental Evaluation of Wheelchair-Mounted Robotic Arms","d":"Researchers from the University of South Florida's Rehabilitation Engineering program are looking for volunteers to participate in a research study for experimental evaluation of wheelchair-mounted robotic arms (WMRAs). Participants will operate commercially available and developmental WMRAs in a physical test environment. The study will serve to identify desirable design features of WMRAs and input devices so that future production systems may further increase the quality of life of potential…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01652352"},{"n":"NCT04083794","t":"Exploration of Blood Flow Regulation to Bone in Humans","d":"Without blood flow, bone cannot maintain its integrity. Bone blood flow responds to various local and systemic factors, however, bone perfusion in humans remains relatively unstudied. The investigators will study key mechanisms that regulate bone perfusion in able-bodied and contrast responses to those with spinal cord injury (SCI). SCI is a model of chronic reduced loading with loss of sympathetic regulation. In tibial cortical bone, the investigators will: 1) determine the impact of…","s":"Completed","tr":["Devices"],"o":["Blood Pressure"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04083794"},{"n":"NCT07722429","t":"Exploration of the Effectiveness and Mechanism of Personalized Epidural Electrical Stimulation in Improving Upper Limb Function in Participants With Spinal Cord Injury","d":"This study aimed to determine whether cervical spinal cord epidural electrical stimulation (EES) can activate upper-limb muscles in individuals with spinal cord injury.","s":"Recruiting","tr":["Electrical Stimulation","Epidural Stimulation"],"o":["Arm Movement","Hand Movement","Quality of Life","Spasticity"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07722429"},{"n":"NCT03337048","t":"Exploratory Study Investigating Urodynamic Parameters During Catheterisation","d":"The objective of the study is to explore and understand how urodynamic parameters are affected when emptying the bladder with an intermittent catheter.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03337048"},{"n":"NCT05945784","t":"Exploring Accessible Beauty for Individuals With Upper Extremity Deficits","d":"The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities. By examining various factors such as packaging design, product applicators, and ease of use, this research aims to identify barriers faced by individuals with upper extremity disabilities or visual deficits when using beauty products. The study seeks to provide insights and recommendations for improving the accessibility of beauty products, ultimately promoting…","s":"Completed","tr":["Observational"],"o":["Arm Movement"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05945784"},{"n":"NCT06705790","t":"Exploring the Benefits of Pelvic Floor Muscle Training on Bladder, Bowel, and Sexual Function in People With Spinal Cord Injury","d":"The goal of this trial is to learn about the feasibility and benefits of delivering a pelvic floor muscle training program to people with motor-incomplete spinal cord injury. The main questions it aims to answer are: 1. To evaluate the feasibility of delivering a pelvic floor muscle training program to people with spinal cord injury. The investigators will examine recruitment rate, compliance and adherence to the intervention and other study protocols, adverse events, and participant…","s":"Recruiting","tr":["Rehabilitation"],"o":["Bladder Function","Bowel Function","Sexual Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06705790","su":"https://scitrials.org/trial/NCT06705790"},{"n":"NCT06003712","t":"Exploring the Effect of Mindfulness on Quality of Life (QoL) in Spinal Cord Injury (SCI)","d":"The purpose of this study is to determine if practicing mindfulness breathing exercises has an effect on the overall health of persons with SCI","s":"Withdrawn","tr":[],"o":["Blood Pressure","Breathing Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06003712"},{"n":"NCT07519928","t":"Exploring the Feasibility and Benefits of Implementing Pelvic Floor Muscle Training During Inpatient Rehabilitation for People With Spinal Cord Injury","d":"The goal of this clinical study is to determine the feasibility and explore the potential benefits of pelvic floor muscle training during inpatient SCI rehabilitation on urinary, bowel, and sexual function and quality of life in people with SCI. The main questions it aims to answer are: 1. What is the feasibility of recruiting inpatients from SCI rehabilitation to a pelvic floor muscle training program? 2. What is the feasibility and acceptance of the implementation of a pelvic floor muscle…","s":"Recruiting","tr":["Rehabilitation"],"o":["Bladder Function","Bowel Function","Quality of Life","Sexual Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07519928","su":"https://scitrials.org/trial/NCT07519928"},{"n":"NCT06999434","t":"Exploring the Utility of [18F]3F4AP for Demyelination Imaging","d":"The overall objective is to obtain an assessment of the pharmacokinetics of \\[18F\\]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI) and Spinal radiculopathy (SR).","s":"Recruiting","tr":["Drugs"],"o":[],"st":["Connecticut"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06999434"},{"n":"NCT01238549","t":"Extending Veteran Participation in the Validation of the SCI-QOL/CAT","d":"The field of spinal cord injury rehabilitation medicine lacks a reliable, patient reported, health-related quality of life measurement tool. The National Institute of Health has provided funding to develop a spinal cord injury-specific, quality of life survey tool in non-Veterans with spinal cord injury called the spinal cord injury-quality of life (SCI-QOL). This quality of life survey asks questions regarding physical/medical, emotional, and social health as it relates to individuals with…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Bladder Function","Bowel Function","Mental Health","Pain Management","Quality of Life"],"st":["Florida","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01238549"},{"n":"NCT00786968","t":"Extension Study of Intrathecal Enzyme Replacement Therapy for MPS I","d":"This is a one-year extension study of the use of laronidase into the spinal fluid to treat spinal cord compression in mucopolysaccharidosis I. Mucopolysaccharidosis I is a rare genetic condition due to deficiency of the enzyme alpha-l-iduronidase. Spinal cord compression occurs in this condition due to accumulation of material called glycosaminoglycans (GAG). Laronidase is the manufactured form of the enzyme alpha-l-iduronidase that is deficient in mucopolysaccharidosis I patients. The aim of…","s":"Terminated","tr":["Drugs","Surgical Procedure"],"o":[],"st":["California"],"co":["Finland","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00786968"},{"n":"NCT07295067","t":"Extracellular Vesicles for the Treatment of Syringomyelia","d":"This is a open-label, single-arm, dose escalation phase I clinical trial. The goal of this clinical trial is to evaluate the safety and preliminary efficacy of Intrathecal injection human umbilical cord-derived mesenchymal stromal cell-derived extracellular vesicle (hUC-MSC-sEV) in syringomyelia.","s":"Active, not recruiting","tr":["Drugs","Safety","Stem Cells"],"o":["Breathing Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07295067"},{"n":"NCT02203994","t":"Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury","d":"Spasticity is the most problematic self-reported secondary medical problem in patients with spinal cord injury. It has the potential to negatively influence quality of life through restricting activities of daily living. Problematic spasticity can cause pain and fatigue, disturb sleep, contribute to the developement of contractures and pressure ulcers, and has a negative effect on patients morbidity. For this reason there is enormous interest in therapeutic interventions addressing to decrease…","s":"Completed","tr":["Devices"],"o":["Leg Movement","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02203994"},{"n":"NCT03399968","t":"Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients","d":"The global prevalence of spinal cord injury is estimated between 236 to 4187/Million. A spontaneous recovery of the sense-motoric function is decreasing with the time after injury and is only seen sporadically after 1 to 2 years. Treatment options are mainly limited to improvement of the quality of life. The present prospective randomized study is intended as a double-blind, placebo controlled multi-center investigation. Patients suffering from chronic paraplegia (lesion between THII and THX…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":[],"st":[],"co":["Austria"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT03399968","su":"https://scitrials.org/trial/NCT03399968"},{"n":"NCT05432999","t":"Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury","d":"People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence. One of the more prevalent complications is spasticity, which occurs in response to spinal cord damage and the resulting disruption of motor pathways. Common symptoms include spasms and stiffness, and can occur more than once per hour in many people with SCI. Spasticity can have a negative impact over many quality of life domains, including loss of…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05432999"},{"n":"NCT01943656","t":"Eyegaze Systems for Spinal Cord Injury: A Feasibility Study","d":"As technologies are advancing quickly in the healthcare setting, new solutions have become available helping disable people to enhance their ability to communicate. One of these advances is the introduction of the 'eye gaze system'. Through processing eye movements, this device allows a person to write, speak, use the Internet and even control systems in the home or office. In the currently proposed study we aim to evaluate the psychological and functional effects of using the Tobii™ Eyegaze…","s":"Unknown","tr":["Devices"],"o":["Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01943656","su":"https://scitrials.org/trial/NCT01943656"},{"n":"NCT07167680","t":"Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters","d":"The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care. This study will compare two groups of participants: 1. One group will use the iROLL-O+ app, which offers personalized fall prevention tools and strategies. 2. The other group will receive fall prevention information from a well-known program developed by the Centers…","s":"Recruiting","tr":[],"o":["Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07167680"},{"n":"NCT03814876","t":"Family Intervention Following Traumatic Injury","d":"The purpose of this study is to investigate the effectiveness of a manualized intervention (FITS) to families living with brain injury or spinal cord injury. The intervention will be provided by a trained neuropsychologist and consists of 8 structured sessions of 90 minutes duration. The intervention group will be compared to a control group receiving treatment as usual, one psycho-educational group session of a 2 hour duration.","s":"Completed","tr":[],"o":["Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03814876"},{"n":"NCT03153033","t":"Fatigue Induced by Overground Wheelchair Propulsion in Persons With a Spinal Cord Injury: Upper Limb Saving or Straining?","d":"What are the implications of wheelchair propulsion-induced fatigue for the development of shoulder pain and how can this knowledge improve prevention programs? With this project, the \"Shoulder Health and Mobility group\" of the Swiss Paraplegic Research in Nottwil (Switzerland) wants to investigate how fatigue during wheelchair propulsion affects risk factors for shoulder pain of persons with a spinal cord injury (SCI). The investigators want to find out how the handrim wheelchair propulsion…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Arm Movement","Motor Function","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03153033"},{"n":"NCT07299734","t":"Feasibility and Safety of a Combined Augmented Reality and Functional Electrical Stimulation System","d":"Cervical spinal cord injury (cSCI) can result in substantial loss of upper-limb function, with associated socio-economic impact on affected individuals and the healthcare system. Evidence suggests that non-invasive neuromodulation such as functional electrical stimulation (FES) therapy can contribute to regaining upper-limb function, which is a top priority for this population. This pilot study will involve individuals with cSCI using a device that combines augmented reality (AR) and functional…","s":"Recruiting","tr":["Functional Electrical Stimulation (FES)"],"o":["Arm Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07299734","su":"https://scitrials.org/trial/NCT07299734"},{"n":"NCT05989906","t":"Feasibility of a Sprint Interval Training Program During Inpatient Spinal Cord Injury Rehabilitation","d":"This study will assess the feasibility and efficacy of 3 treatments to increase physical activity during and after inpatient rehabilitation (IPR) for new spinal cord injuries: 1. Program of sprint interval training (SIT) on an arm crank ergometer during IPR 2. SIT + Provision of an arm ergometer (ERGO) for home use 3. SIT + ERGO for home use + Motivational interviewing to increase adherence to exercise during and after IPR. The primary outcome is minutes per week of moderate to vigorous…","s":"Enrolling by invitation","tr":["Rehabilitation"],"o":["Arm Movement","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05989906","su":"https://scitrials.org/trial/NCT05989906"},{"n":"NCT05302999","t":"Feasibility of Early Gabapentin as an Intervention for Neurorecovery","d":"The objective of the proposed study is to conduct the first ever prospective, dose-exploration trial to test the feasibility of early administration of gabapentin as an intervention for neurorecovery. This research project falls under the Intervention Development stage of research as the primary goal is to assess the feasibility of conducting a well-designed intervention efficacy study in the future.","s":"Recruiting","tr":["Safety"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05302999","su":"https://scitrials.org/trial/NCT05302999"},{"n":"NCT03941600","t":"Feasibility of Exercise and Spinal Cord Injury","d":"The purpose of the study is to examine the impact of a community-based exercise intervention (CBEI) for persons with spinal cord injury (PwSCI) on physiological and psychological well-being and identify barriers and facilitators to implementation.","s":"Completed","tr":[],"o":["Arm Movement","Mental Health","Motor Function","Pain Management"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03941600"},{"n":"NCT03152110","t":"Feasibility of HIIT in Spinal Cord Injury","d":"Spinal cord injury (SCI) is debilitating to an individual's health, functional capacity and quality of life. This contributes to a sedentary lifestyle and an elevated risk for cardiometabolic and hypokinetic diseases. While physical activity is promoted in persons with SCI to reduce incidence of secondary disabling conditions, a majority of individuals are inactive and have low levels of fitness. High intensity interval training (HIIT) is a form of exercise characterized by brief, intermittent…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Leg Movement","Pain Management","Quality of Life"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03152110"},{"n":"NCT06230627","t":"Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq","d":"Feasibility of Home-Based Rehabilitation on Body Composition, some Anthropometric Measures and Muscular Strength after interruption 4-5 years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq Summary Background: The war in Mosul wrecked hospitals and rehab centers, leaving a gap in rehabilitation services. This resulted in a need for alternative solutions for rehabilitation. Objectives: This study aims to create a home-based rehabilitation program (HBRP) that fits the…","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function","Trunk Control"],"st":[],"co":["Tunisia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06230627"},{"n":"NCT05556057","t":"Feasibility of Mindfulness Meditation Training and Home Practice in Persons With Spinal Cord Injury","d":"The purpose of this study is to evaluate the feasibility and acceptability of a 6-week app-guided Mindfulness meditation training (MM) intervention and health education (active control) condition in people with spinal cord injury (SCI) who have chronic pain and to examine the feasibility of data collection procedures","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05556057"},{"n":"NCT02225028","t":"Feasibility of Telephone Counseling to Increase Physical Fitness in SCI","d":"People with spinal cord injuries (SCI) are among the least physically active groups in our society. Approximately 1 in 4 healthy young persons with spinal cord injury (SCI) does not have sufficient fitness to perform many essential activities of daily living. About 50% of people with SCI engage in no leisure time physical activity. That is, they do not wheel or walk for pleasure, don't play a sport, don't exercise at home or go to a gym. As a result of this, cardiovascular, endocrine and…","s":"Completed","tr":[],"o":["Blood Pressure","Mental Health","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02225028"},{"n":"NCT05724173","t":"Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia","d":"The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.","s":"Recruiting","tr":["Devices"],"o":[],"st":["California","Massachusetts"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05724173"},{"n":"NCT06094205","t":"Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)","d":"The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to speak fluently to communicate via a computer just by trying to speak.","s":"Recruiting","tr":["Brain Stimulation","Devices"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06094205","su":"https://scitrials.org/trial/NCT06094205"},{"n":"NCT06511934","t":"Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)","d":"People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, the investigators seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06511934","su":"https://scitrials.org/trial/NCT06511934"},{"n":"NCT04726891","t":"Feasibility of the First Known Adaptive Intervention for People With SCI","d":"The overall goal of the proposed research is to conduct a pilot study to test the feasibility and acceptability of a home-based exercise intervention (SMART-HEALTH). The primary purpose of the pilot study is to assess the feasibility of intervention delivery (Aim 1), the acceptability of the intervention by participants (Aim 2) and estimate effect sizes for a future trial (Aim 3).","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Mental Health","Motor Function","Pain Management"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04726891"},{"n":"NCT00882843","t":"Feasibility Study for the Use of Low-magnitude, High Frequency Mechanical Stimulation of Bone in Persons With Spinal Cord Injury (SCI)","d":"In persons with SCI, because of inherent considerations, the use of mechanical stimulation has not been studied to determine improvement in bone mass. To achieve maximum transmission of the vibration from a vibrating plate to the lower body, the legs must be extended and the feet firmly placed against the surface plate of the device. Thus, these logistical considerations must be addressed to perform this mechanical intervention in persons with SCI. In those with complete or almost complete…","s":"Completed","tr":["Devices","Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00882843"},{"n":"NCT05406739","t":"Feeding Regulation in SCI","d":"The overall purpose of this research is to understand the reasons why persons with spinal cord injuries eat more calories than they need to \"burn\", stay alive, and function. This research will investigate how quickly food moves through a participant's body, the hormones in the participant's body that control energy and digestion, and a participant's impressions of hunger after eating a meal. This will be compared in persons with and without a spinal cord injury.","s":"Completed","tr":[],"o":["Bowel Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05406739"},{"n":"NCT02455336","t":"Fenofibrate Treatment in SCI","d":"Cardiovascular disease-related morbidity in persons with spinal cord injury (SCI) occurs earlier in life, at a greater prevalence than that of the general population, and is the primary cause of death after the first year of injury. During the chronic phase of SCI, a characteristic dyslipidemia emerges, which is characterized by low serum high density lipoprotein cholesterol (HDL-C) concentrations, with values often qualifying to be an independent risk factor for coronary artery disease, and…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02455336"},{"n":"NCT07640152","t":"Fermented Foods and Bowel Health in SCI","d":"The goal of this clinical trial is to learn whether consuming a high fermented food diet improves bowel function and gut health in adults with chronic spinal cord injury (SCI). The study will also evaluate the feasibility and tolerability of consuming fermented foods daily for 10 weeks. The main questions it aims to answer are: 1. Does a high fermented food diet improve neurogenic bowel dysfunction symptoms and colonic transit in adults with SCI? 2. Does fermented food intake change gut…","s":"Not yet recruiting","tr":["Nutrition"],"o":["Bowel Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07640152","su":"https://scitrials.org/trial/NCT07640152"},{"n":"NCT02144558","t":"Fertility of Spinal Cord Injured Men","d":"Spinal cord injured (SCI) men, para or tetraplegic, most often have an infertility, caused among others by a deficiency of sperm quality particularly motility and vitality. Several mechanisms have been proposed: low frequency of ejaculation, recurrent urinary tract and seminal infections, presence of an inflammatory syndrome (IS) and an oxidative stress (OS). However, no French study of sperm quality has been conducted in this population that could identify aggravating factors of sperm quality…","s":"Completed","tr":["Devices"],"o":["Bladder Function","Sexual Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02144558"},{"n":"NCT05863988","t":"FES and Upper Limb Loading Exercises Outcome Comparison on Hand Function in Spinal Cord Injury Patients","d":"This study is conducted to assess the effectiveness of functional electrical stimulation Vs limb loading exercises on hand grip strength,dexterity and function in patients with subacute cervical spinal cord injury.","s":"Unknown","tr":[],"o":["Hand Movement"],"st":[],"co":["Pakistan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05863988","su":"https://scitrials.org/trial/NCT05863988"},{"n":"NCT07385456","t":"FES Arm Cycling on Functional Ability and Strength in People With SCI","d":"The goal of this feasibility study is to determine if Functional Electrical Stimulation (FES) arm cycling can be used to improve arm functional ability and arm strength in people with Spinal Cord Injury (SCI). The main questions it aims to answer are: * What is the feasibility of FES UL cycling in people with acute tetraplegia? * What are the potential effects of FES UL cycling on strength and functional ability in people with acute tetraplegia? Participants will: * Complete an FES arm cycling…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07385456"},{"n":"NCT03810963","t":"FES Cycling and Nutritional Counseling for Battling Obesity After SCI","d":"Individuals who suffer from paralysis after spinal cord injury (SCI) are estimated to have an even greater (66%) prevalence of obesity. Obesity is a major public health concern and is associated with a plethora of cardiometabolic health complications (heart disease, stroke and type II diabetes mellitus). Although the benefits of physical activity to counteract obesity and cardiometabolic disease have been documented, SCI typically limits voluntary exercise to the often injured arms (60-90%). On…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Nutrition"],"o":["Blood Pressure"],"st":["Mississippi"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03810963"},{"n":"NCT07588503","t":"FES Cycling With BFR in the Spinal Cord Injury Population","d":"Cardiometabolic Disease (CMD) is the silent killer within the spinal cord injury/disease (SCI/D) population. Many SCI/D patients' initial CMD presentation is with a heart attack, stroke, or sudden cardiac death, highlighting the need for interventions to reduce CMD risk. CMD contributes to 46% of deaths, with 30-50% of the SCI/D population living with undiagnosed CMD. Treating CMD risk is more challenging in the SCI/D population due to prolonged inactivity, inability to exercise, and excessive…","s":"Recruiting","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07588503","su":"https://scitrials.org/trial/NCT07588503"},{"n":"NCT02008149","t":"FES Rowing for Skeletal Health After SCI","d":"Following a complete spinal cord injury (SCI), individuals experience progressive bone loss, especially in the legs, with up to 70% of persons with SCI sustaining a fracture at some point during their lifetime. Fractures following SCI are costly to treat and more than half of patients experience a medical complication, requiring extended hospitalization, resulting in a substantial impact on their quality of life. To reduce the incidence of fractures, more effective rehabilitation strategies to…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Bone Strength","Quality of Life"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02008149"},{"n":"NCT01208688","t":"FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI","d":"The main objective of this study is to determine the effectiveness of a new treatment regime that uses electrical stimulation for the improvement of hand function in persons with spinal cord injuries (SCI). This treatment has been shown to be useful for stroke patients, and our preliminary work indicates that this may also be the case with SCI patients. Our approach to functional electrical stimulation (FES) represents a departure from the established FES approaches, which involve developing…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01208688"},{"n":"NCT05908175","t":"FES-assisted Gait Intervention in People with Spinal Cord Injury - Pilot Study","d":"A spinal cord injury (SCI) disrupts the communication within the nervous system, leading to limitations in sensorimotor activities such as walking. Regular use of functional electrical stimulation (FES) can result in recovery of voluntary muscle control and muscle strength. Locomotor training with FES may be a promising method to improve gait function. The primary objective of this pilot study is to assess the feasibility and safety of an FES-assisted gait training intervention. Secondary…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Motor Function","Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05908175"},{"n":"NCT07645144","t":"FES-assisted Gait Training for Incomplete Spinal Cord Injury","d":"Spinal cord injuries (SCI) impair neural communication, leading to difficulties in walking due to muscle weakness, altered reflexes, and impaired muscle activation below the injury. Functional electrical stimulation (FES) has been shown to enhance voluntary control, strength, and walking performance when used during gait training. This study aims to assess whether the FES yields superior improvements in walking ability compared to conventional gait training without stimulation.","s":"Enrolling by invitation","tr":["Functional Electrical Stimulation (FES)"],"o":["Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07645144","su":"https://scitrials.org/trial/NCT07645144"},{"n":"NCT01426555","t":"FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)","d":"This is a research study to determine the effects of functional electrical stimulation (FES) rowing and a drug called zoledronic acid in bone health. The investigators hoped to learn if zoledronic acid treatment will increase bone mineral density in persons with chronic spinal cord injury (SCI) who received it. The investigators also want to find out if zoledronic acid is safe for persons with SCI to take without causing too many side effects.","s":"Terminated","tr":["Drugs","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Bone Strength"],"st":["Massachusetts"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01426555"},{"n":"NCT02676154","t":"Fesoterodine for Amelioration of Autonomic Dysreflexia (AD) Following Spinal Cord Injury (SCI)","d":"This study will be investigating the effects of fesoterodine on autonomic dysreflexia (AD) in patients with spinal cord injuries (SCI). The goal of the study is to examine the effect of increasing daily use of fesoterodine on episodes of high blood pressure triggered by urinary bladder contractions.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Blood Pressure","Bowel Function","Quality of Life","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02676154"},{"n":"NCT06104735","t":"Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury","d":"While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of \"Fire Together, Wire Together\" - when brain stimulation is synchronized with spinal cord stimulation, nerve circuits in the spinal cord strengthen - a phenomenon termed \"Spinal Cord Associative Plasticity\", or SCAP. This project will build on the team's promising preliminary findings. When one pulse of brain stimulation is…","s":"Recruiting","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06104735","su":"https://scitrials.org/trial/NCT06104735"},{"n":"NCT03146728","t":"Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia","d":"There are over 44,000 persons living with spinal cord injury (SCI) in Canada, who face substantial challenges in maintaining a healthy body composition after injury. As a result, obesity, diabetes and cardiovascular disease are prevalent in this population. Guidelines indicating that twice weekly 20-minute sessions of exercise (plus resistance training) will increase physical fitness in those with SCI have been recently published. However, no SCI-specific guidelines indicating the volume of…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03146728"},{"n":"NCT04649814","t":"Finnish Spinal Cord Injury Study (FinSCI)","d":"The purpose of the Finnish Spinal Cord Injury Study (FinSCI) is to identify factors related to the health and functioning of people with spinal cord injury (SCI), their challenges with accessibility and how such factors are interconnected. The International Classification of Functioning, Disability and Health (ICF) is used in the study as a structured framework. The study participants will be recruited from three SCI outpatient clinics, which together are responsible for the life-time care of…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04649814"},{"n":"NCT06137456","t":"First Report of a New Exoskeleton in Incomplete Spinal Cord Injury","d":"The goal of this clinical trial is to compare the effects of exoskeletal robotic therapy and conventional exercise therapy in incomplete spinal cord injury (SCI). The main questions it aims to answer are: * Is exoskeletal robotic therapy effective in improving functional ambulation in SCI? * Is exoskeletal robotic therapy effective in enhancing Activities of Daily Living in SCI? Participants treated with either: * Exoskeletal robotic therapy along with conventional exercise therapy, or * Only…","s":"Completed","tr":["Exoskeleton"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06137456"},{"n":"NCT06922890","t":"First-in-Human Clinical Trial of STUP-001, an In Vivo Direct Cell Conversion Gene Therapy for AIS-A/B Chronic Spinal Cord Injury","d":"This study aim to investigate the safety and exploratory efficacy of STUP-001 which is AAV-based spinal cord injury investigational product.","s":"Recruiting","tr":[],"o":["Regeneration"],"st":[],"co":["South Korea"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06922890","su":"https://scitrials.org/trial/NCT06922890"},{"n":"NCT04307017","t":"Fitness Training Using WBEMS Among Individuals With SCI","d":"Up to 15 individuals living with chronic SCI will be recruited for this study. Each participant will complete an initial clinical assessment before starting a 10-week training program. The training program will consist of three 45-minute Whole-Body Electrical Muscle Stimulation (WBEMS)-augmented exercise training sessions for 10 weeks. At each training session, all adverse events (pain, redness, injury, etc.) will be recorded along with participants' comments concerning comfort (i.e. Objective…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Motor Function","Pain Management","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04307017"},{"n":"NCT03833674","t":"FLO2 for Recovery After SCI","d":"Acute intermittent hypoxia (AIH) involves short (\\~1-2min) bouts of breathing low oxygen air to stimulate spinal neuroplasticity. Studies in rodents and humans indicate that AIH improves motor function after spinal cord injury (SCI). This study will use a double blind, cross-over design to test if the combination of AIH and respiratory strength training improves breathing function more than either approach alone in adults with chronic SCI.","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Breathing Function","Motor Function","Plasticity"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03833674"},{"n":"NCT01618786","t":"Flooring for Injury Prevention Trial","d":"This study will evaluate the efficacy of novel compliant flooring in reducing injuries due to falls in a long-term care facility, determine the cost effectiveness of this intervention, and assess perceptions about compliant flooring among staff, residents, and families. The investigators hypothesize that compliant flooring will (1) reduce the incidence of injuries due to falls in long-term care residents; (2) represent an overall cost-savings when material and implementation costs are…","s":"Completed","tr":[],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01618786"},{"n":"NCT02074670","t":"fMRI In Spinal Cord Injury Patient After Rehabilitation","d":"The purpose of this study was to evaluate the potential reorganization in the sensorimotor cortex in spinal cord injury (SCI) patients after Body Weight Supported Treadmill Training (BWSTT) associated with conventional motor rehabilitation. The investigators hypothesized that training with weight bearing associated with conventional motor rehabilitation will be able to reorganize the brain.","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02074670"},{"n":"NCT01815554","t":"Follow up Study of Diaphragm Pacing for Patients With High Tetraplegia","d":"This is an observational longitudinal study designed to identify and describe long term outcomes for patients with high tetraplegia who use a Diaphragmatic Pacing System (DPS). As this is not a randomized or experimental study, no specific hypotheses are proposed. The data collected will enable us to answer the following research questions: 1. What are the patterns of long-term DPS use (hours per day using DPS, changes in DPS stimulus parameters, abandonment of DPS and related reasons). 2. What…","s":"Completed","tr":["Devices","Observational"],"o":["Breathing Function"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01815554"},{"n":"NCT07103993","t":"Food Intake and Thermogenesis in High Spinal Cord Injury","d":"The purpose of this research is to determine the effects of food on cardiovascular and metabolic health in men with and without spinal cord injury (SCI).","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07103993","su":"https://scitrials.org/trial/NCT07103993"},{"n":"NCT03457558","t":"Food Security and Perceptions and Barriers to Healthy Eating in Individuals With Spinal Cord Injuries","d":"Food security is one's ability to get food. Individuals with a Spinal Cord Injury (SCI) have many risk factors for low rates of food security. Some of these risk factors include lower levels of income and employment. Our long-term goal is to identify if food security is more prevalent in the SCI population, and to develop ways to improve food security in the SCI population. The purpose of this study is to determine the rates of food insecurity in a sample of people living with a SCI and to…","s":"Completed","tr":["Observational"],"o":[],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03457558"},{"n":"NCT04781621","t":"Foundational Ingredients of Robotic Gait Training for People With Spinal Cord Injury During Inpatient Therapy","d":"The FIRST project compares the dose of robotic gait training (RGT) with usual care gait training for patients with spinal cord injury (SCI) undergoing rehabilitation at Baylor Scott \\& White Institute for Rehabilitation (BSWIR).","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life","Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04781621"},{"n":"NCT02357914","t":"Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia","d":"Shoulder pain is very common in people with spinal cord injury (SCI). Persons with high-level paraplegia have higher chances to suffer shoulder pain and injury than those with lower-level paraplegia due to the shoulder muscle imbalance. As people with SCI overuse the shoulder during routine daily activities, the onset of pain or injury lead to increased healthcare expenses, limitation in activity, depression, decreased participation, and reduced quality of life. One of the main reasons of…","s":"Unknown","tr":["Observational"],"o":["Pain Management"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02357914","su":"https://scitrials.org/trial/NCT02357914"},{"n":"NCT03108950","t":"From Clinic to Community: An Information and Communication Technology (ICT) Home-Based Exercise Training System for Translating Clinical Findings","d":"The specific aim of the study in our example is to conduct a feasibility translational home-based exercise trial established in the LEADERS (R2) project with the TExt-ME tele-exercise training system for participants with neurologic disability. We hypothesize that participants in this home-based tele-exercise training program will achieve similar gains in health and function outcomes as the onsite exercise training program. Further, there will be no difference in adverse side effects (safety)…","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Hand Movement","Mental Health","Motor Function","Pain Management","Trunk Control","Walking Function"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03108950"},{"n":"NCT00883142","t":"Functional and Physiological Responses to Lokomat Therapy (Pilot Study)","d":"Individuals with neurological deficiencies such as those who have spinal cord injury, stroke, traumatic brain injury, Parkinson's disease, and multiple sclerosis often lose their ability to ambulate over ground. Loss of functional mobility not only impedes everyday life, but may also affect many systems and organs in the body. The investigators are interested in obtaining a wide variety of data in order to obtain a better understanding of changes that occur as a result of receiving Lokomat…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Blood Pressure","Breathing Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00883142"},{"n":"NCT05681936","t":"Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury","d":"Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible…","s":"Recruiting","tr":["Observational"],"o":["Bladder Function","Hand Movement","Motor Function","Pain Management","Quality of Life","Regeneration","Sensory Function","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05681936","su":"https://scitrials.org/trial/NCT05681936"},{"n":"NCT03908047","t":"Functional Changes in the Brain After Tibial Nerve Stimulation: a Pilot Study","d":"The lower urinary tract is innervated by the autonomous (sympathetic, parasympathetic) and the somatic nervous system. Afferent information from the lower urinary tract (LUT) (e.g. filling state and volume of the urinary bladder) is conducted via the dorsal roots to the sacral spinal cord and from there to the pontine micturition center (PMC) in the brain stem. The PMC has several connections to other cortical areas. These complex interactions with the cortex enable voluntary control of the LUT…","s":"Completed","tr":["Electrical Stimulation","Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03908047"},{"n":"NCT03048331","t":"Functional Electrical Stimulation (FES) and Reconstructive Tetraplegia Hand and Arm Surgery","d":"FES is a common and established method in the rehabilitation of persons with spinal cord injury (SCI). Some known effects of FES were investigated in several studies e.g. avoiding disuse and denervation atrophy, improving muscle force, power output and endurance changing muscle fibre type, increasing cross sectional area of muscle, increasing muscle mass, activation of nerve sprouting, reducing spasticity and motor learning. Most of the studies investigated the impact of FES in the lower limbs…","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation","Surgical Procedure"],"o":["Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03048331"},{"n":"NCT00245726","t":"Functional Electrical Stimulation (FES) Cycling for Children With Spinal Cord Injuries (SCI)","d":"The overall objective of this research project is to examine the clinical efficacy of lower extremity cycling with functional electrical stimulation to improve the health and fitness of children with spinal cord injuries (SCI). To achieve this goal, a controlled, randomized study will be conducted with thirty children who have sustained a spinal cord injury. The children in the study will be assigned to one of three groups: those receiving functional electrical stimulation (FES) leg cycling…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Blood Pressure","Bone Strength","Leg Movement","Motor Function","Quality of Life","Spasticity"],"st":["Maryland","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00245726"},{"n":"NCT01479777","t":"Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury","d":"The research is being done to find out if Functional Electrical Stimulation (FES) stepping can improve the function of people with spinal cord injury that paralyzes.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Blood Pressure","Breathing Function","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01479777"},{"n":"NCT04064385","t":"Functional Electrical Stimulation Cycling in SCI","d":"Spinal cord injury (SCI) is a devastating, life-altering injury; requiring tremendous changes in an individual's lifestyle. Cycling, provides an ideal way for individuals with SCI to exercise and address the long-term consequences of SCI by targeting the lower extremity muscles. Cycling with the addition of functional electrical stimulation (FES) allows persons with paralysis to exercise their paretic or paralysed leg muscles. The Queen Elizabeth National Spinal Injury Unit (QENSIU) in Glasgow…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04064385","su":"https://scitrials.org/trial/NCT04064385"},{"n":"NCT03834324","t":"Functional Electrical Stimulation During Cycling in People With Spinal Cord Injury","d":"Neuroscience research that has identified potential for recovery (neuroplasticity) following incomplete SCI has changed clinical practice away from compensation strategies towards optimizing recovery. Important factors include: repetitive exercise, Functional Electrical Stimulation (FES) and appropriate feedback. The iCycle combines repetitive exercise with FES and provides feedback on performance in a virtual cycle race. Unlike previous devices, performance in the race is determined only by…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Transcranial Magnetic Stimulation (TMS)"],"o":["Motor Function","Plasticity","Quality of Life","Spasticity","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03834324"},{"n":"NCT00589199","t":"Functional Electrical Stimulation for Production of Artificial Cough","d":"The purpose of the present study is to assess the utility of abdominal muscle stimulation to provide large positive airway pressures and expiratory airflow thus simulating cough. Restoration of cough in spinal cord injured patients may reduce the incidence of respiratory complications such as atelectasis, respiratory tract infections and respiratory failure.","s":"Completed","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Breathing Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00589199"},{"n":"NCT07773974","t":"Functional Electrical Stimulation Plus High Intensity Interval Training at Home","d":"People living with SCI may experience loss of sensation, movement and regular body function. One way to address these impairments is activity-based therapy (ABT), which includes movement-based activities that promote the muscle-brain connection below the level of injury. A technology often used during ABT is functional electrical stimulation (FES), which is an electrical stimulus applied to nerves or paralyzed muscles through sticky gel pads placed on the skin. The purpose of this multi-method…","s":"Not yet recruiting","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Motor Function","Sensory Function","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07773974"},{"n":"NCT02602639","t":"Functional Electrical Stimulation With Rowing as Exercise After Spinal Cord Injury","d":"Currently, those with spinal cord injury (SCI) demonstrate increased prevalence of obesity (75%) cardiovascular disease (30 - 50%), type II diabetes (21%) and osteoporosis in the legs (100%) when compared to the general population. It is important to identify the modes and intensities of exercise most likely to generate a reduction in these inactivity-related diseases in this population. Therefore, the main purpose of this pilot research project is to implement and test a form of a spinal cord…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02602639","su":"https://scitrials.org/trial/NCT02602639"},{"n":"NCT00201968","t":"Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury","d":"The purpose of this study is to evaluate whether an aerobic and resistance training program or a functional electrical stimulation-assisted Walking program is more effective for reducing health complications related to spinal cord injury, for example, the occurrence of bladder infections, pressure sores and/or frequency of spasms. It is hypothesized that the functional electrical stimulation-assisted walking will have a greater impact on secondary complications than the aerobic and resistance…","s":"Unknown","tr":["Functional Electrical Stimulation (FES)"],"o":["Bone Strength","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00201968","su":"https://scitrials.org/trial/NCT00201968"},{"n":"NCT05411692","t":"Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury","d":"As functional electrical stimulations has evident role in improving motor control in tenodesis function (power and precision grip) but its results are considered to be short term so addition of task oriented approach i.e. motor priming exercises could enhance the treatment effects . Priming is a mechanism that could easily be a part of a restorative occupational therapy approach, is a therapeutic method with the intent to improve function by targeting underlying neural mechanisms…","s":"Completed","tr":["Rehabilitation"],"o":["Hand Movement","Motor Function","Plasticity","Quality of Life","Sensory Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05411692"},{"n":"NCT05221723","t":"Functional Interval Training for People With Spinal Cord Injury and Their Care Partners","d":"Functional Interval Training for People with Spinal Cord Injury and Their Care Partners (SCI-FIT) aims to address barriers to physical activity for people with spinal cord injury and their care partners. This research study provides free, twice weekly group-based, adaptable exercise classes for people with spinal cord injury and their care partners.","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Leg Movement","Motor Function","Quality of Life","Walking Function"],"st":["Arkansas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05221723"},{"n":"NCT00011557","t":"Functional Magnetic Micturition in Patients w/SCI","d":"This project will determine the ultimate usefulness of functional magnetic stimulation (FMS) as an assistive device for voiding in patients with SCI.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00011557"},{"n":"NCT00507546","t":"Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia","d":"The purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep disruption.","s":"Completed","tr":["Drugs"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00507546"},{"n":"NCT02510365","t":"Functional Neural Regeneration Collagen Scaffold Transplantation in Acute Spinal Cord Injury Patients","d":"The study is designed to assess the safety and efficacy of functional neural regeneration collagen scaffold transplanted into acute spinal cord injury patients.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":5,"rlc":5,"cu":"https://clinicaltrials.gov/study/NCT02510365","su":"https://scitrials.org/trial/NCT02510365"},{"n":"NCT03966794","t":"Functional Scaffold Transplantation Combined With Epidural Electrical Stimulation for Spinal Cord Injury Repair","d":"The study is designed to assess the role of functional neural regeneration collagen scaffold transplantation combined with epidural electrical stimulation in spinal cord injury patients.","s":"Unknown","tr":["Epidural Stimulation"],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03966794","su":"https://scitrials.org/trial/NCT03966794"},{"n":"NCT06391658","t":"Functional Training Improves the Functional Capacity and Physical Fitness of People Whit Spinal Cord Injury","d":"The aim of this study is to understand the effect of adapted functional training on the physical fitness, functionality and quality of life of individuals with SCI after social distancing due to COVID-19. The main question\\[s\\] it aims to answer are: * Are the participants of the functional training program adapted for people with spinal cord injury show better results in functional capacity in post-test evaluations training period, when compared to your results in the functional training…","s":"Completed","tr":[],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06391658"},{"n":"NCT03343132","t":"Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury","d":"Adaptive gait assessements will be evaluated as a potential new marker for tracking locomotor recovery throughout rehabilitation of spinal cord injury subjects. To this end, controls, subacute and chronic patients will be assessed at two timepoints with 3 month standard rehabilitation inbetween. The specific assessments will require the participant to acitvely modulate their gait pattern to fullfill specific task constraints. Their performance will be assessed via 3D kinematics, kinetics and…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03343132"},{"n":"NCT02808078","t":"Gait Adaptation for Stroke Patients With Augmented Reality","d":"The GASPAR trial is a pragmatic, parallel-arms, single-center, non-blinded, superiority randomized control trial in neurorehabilitation. The main objective is to test whether a 4 weeks gait rehabilitation program that uses augmented reality is superior to a conventional treadmill training program of equivalent intensity. Baseline assessments precede allocation, which consists in blocking randomization (2:1 ratio) with stratification according to the disease etiology. Post-intervention…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02808078","su":"https://scitrials.org/trial/NCT02808078"},{"n":"NCT04055610","t":"Gait Training for Individuals With Paraplegia Using the H-MEX Exoskeleton","d":"This study evaluates the feasibility and effects of H-MEX powered exoskeleton in individuals with paraplegia as a result of spinal cord injury.","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["South Korea"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04055610","su":"https://scitrials.org/trial/NCT04055610"},{"n":"NCT02903472","t":"Gastrointestinal and Urinary Tract Microbiome After SCI","d":"Changes in the GI microbiota and/or metabolomics have been linked to evolving transformations in immune system function and infection rates in experimental SCI in animal models. A recent study involving chronic survivors of SCI show distinct GI microbiome changes in comparison to healthy controls. GI microbial metabolism of dietary components has been causally linked to various health conditions, such as cardiovascular disease, infections, which is an ongoing concern for chronic SCI survivors…","s":"Completed","tr":["Nutrition","Observational"],"o":["Bladder Function","Blood Pressure","Bowel Function"],"st":["New York"],"co":["Canada","Spain","Switzerland","Turkey (Türkiye)","United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02903472"},{"n":"NCT07127172","t":"GB-PRIME: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","d":"The GB-PRIME Study is an early feasibility study designed to assess the clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions. The N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["United Kingdom"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07127172","su":"https://scitrials.org/trial/NCT07127172"},{"n":"NCT01253746","t":"Genetics of Neural Tube Defects","d":"The Genetics of Neural Tube Defects Study at the University of Miami: The University of Miami John P. Hussman Institute for Human Genomics is looking for families to participate in research to identify the genetic and environmental factors that contribute to Neural Tube Defects (NTD). Our research goal is to better understand the genetic and environmental causes of both open NTD, like spina bifida and anencephaly, and closed NTD, like lipomeningocele and tethered cord. This will eventually lead…","s":"Unknown","tr":["Observational"],"o":["Quality of Life"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01253746"},{"n":"NCT03931408","t":"Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections","d":"Participants will undergo daily gentamicin bladder instillations to determine if its use will reduce the rate of symptomatic urinary tract infections (UTIs) as well as the use of oral and intravenous antibiotics in adults with chronic spinal cord injury (SCI) who have recurrent UTIs. Participants are randomized into one of three groups: 1) Gentamicin and saline instillation 2) Saline only instillation 3) Standard of care, no instillation.","s":"Completed","tr":["Drugs"],"o":["Bladder Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03931408"},{"n":"NCT03503513","t":"Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury","d":"A non-randomized study evaluating the efficacy of intravesical gentamicin on the occurrence rate of urinary tract infections and bladder complications in patients after spinal cord injury (SCI), and to assess its effectiveness in promoting overall quality of life (QOL), community living, and participation.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03503513"},{"n":"NCT04847609","t":"GentleCath Air (Urinary Self-catheterization) - Pain in Female Patients With Neurological Vesico-sphincter Disorders","d":"The purpose of this study is to evaluate the rate of occurrence of urethral pain in female patients with neurological vesico-sphincter disorders whilst performing self-catheterization using GentleCath™ Air catheters.","s":"Withdrawn","tr":["Devices","Observational"],"o":["Bladder Function","Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04847609"},{"n":"NCT05470751","t":"GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology","d":"Male self catherterisng observational study.","s":"Completed","tr":["Devices","Observational"],"o":["Bladder Function","Quality of Life"],"st":["New Jersey","Pennsylvania"],"co":["France","United Kingdom","United States"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05470751"},{"n":"NCT00786604","t":"Glucose Study, Spinal Cord Injury","d":"The purpose of this research study is to find out how blood sugar levels change during the day and night in people living with spinal cord injuries (SCI) and then to compare that with people who do not have a spinal cord injury. As people with SCI get older they become more likely to develop health problems, just like everyone else. However, SCI increases the risk of certain problems. The amount of time post-SCI can also increase the risk of certain problems. This research project will focus on…","s":"Completed","tr":["Observational"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00786604"},{"n":"NCT06706284","t":"Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes","d":"It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other information about type 2 diabetes and obesity.","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["Texas"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06706284","su":"https://scitrials.org/trial/NCT06706284"},{"n":"NCT07467382","t":"GOAT (Gait Observation of Achilles Tendon)","d":"The purpose of this study is to evaluate the mechanical properties of the Achilles tendon (stiffness, length, volume) and the force production capacities of the gastrocnemius medialis muscle in patients with spastic paresis (post-stroke or incomplete spinal cord injury) compared to healthy subjects, during gait.","s":"Not yet recruiting","tr":["Observational"],"o":["Spasticity","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07467382"},{"n":"NCT05339932","t":"Grand Valley State University (GVSU) Skills on Wheels","d":"Manual wheelchairs (MWCs) are widely used by children with physical disabilities, yet many of these children are unable to use their wheelchair independently. Instead, they depend on others to push them. This dependency results in limited opportunities to decide what they want to do and where they want to go, leading to learned helplessness, social isolation, decreased participation, and restricted involvement in physical activities. Furthermore, unsafe MWC use increases the risk of injury, as…","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05339932","su":"https://scitrials.org/trial/NCT05339932"},{"n":"NCT05863754","t":"Grasp-Release Assessment of a Networked Neuroprosthesis Device","d":"The overall objective of this trial is to characterize the safety and effectiveness of the Networked Neuroprosthesis Device - Upper Extremity (NP-UE) in individuals living with cervical SCI.","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05863754","su":"https://scitrials.org/trial/NCT05863754"},{"n":"NCT03447509","t":"Grasping Function After Spinal Cord Injury","d":"The overall goals of this proposal are to examine the contribution of physiological pathways to the control of grasping behaviors after cervical SCI, and to maximize the recovery of grasping by using tailored non-invasive brain stimulation and acoustic startle protocols with motor training. The investigators propose to study two basic grasping behaviors, which are largely used in most daily-life activities: a precision grip and a power grip.","s":"Terminated","tr":["Devices"],"o":["Hand Movement","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03447509"},{"n":"NCT03190863","t":"Grasping Rehabilitation Using Motor Imagery With or With no Neurofeedback After Tetraplegia","d":"Motor imagery has shown promising results to optimize tenodesis grasp in individuals with C6-C7 tetraplegia. However, efficacy of using motor imagery to improve grasping after tetraplegia requires further study with higher level of evidence. In addition, controlling covert practice remains difficult due to the absence of overt movements. However, similar brain activity measured during both over and cover movements makes possible to provide visual information about the covert practice…","s":"Unknown","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":[],"co":["France"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT03190863","su":"https://scitrials.org/trial/NCT03190863"},{"n":"NCT03658798","t":"Grasping Rehabilitation With Functional Electrical Stimulation Garment","d":"This study tests the feasibility, safety and efficacy of garments embedding conductive electrodes (FES-shirt) for the independent delivery of functional electrical stimulation (FES). 12 people with SCI and 12 people with stroke who have some degree of arm paralysis will receive 40 hours of FES with these FES-shirt. The ability to use the FES-shirts and the improvement in function while receiving FES will indicate the immediate benefits. Their functional capabilities will be measured before and…","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03658798"},{"n":"NCT07083713","t":"Group Coaching Study for Life Goals","d":"This study plans to implement's group coaching with neurodivergent STEM undergraduate students, individuals with spinal cord injuries and their caregivers, and individuals with Ehler's Danlos Syndrome. A trained coach will facilitate the 10 group coaching sessions using the project created coaching protocol. Assessments at pretest and posttest will include two measures addressing the concept of self-efficacy and two others addressing belonging, as well as a battery of tools estimating…","s":"Enrolling by invitation","tr":[],"o":["Mental Health"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07083713","su":"https://scitrials.org/trial/NCT07083713"},{"n":"NCT03457714","t":"Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial","d":"In Canada the prevalence of spinal cord injury (SCI) is approximately 85,556, with incidence rates of traumatic and non-traumatic SCI at 1,785 and 2,286 cases per year, respectively. Common secondary health conditions experienced by individuals with SCI include psychological distress and pain. Appropriate management of these secondary conditions, through a multidisciplinary approach, is imperative as they have been shown to contribute to slower recovery, increased negative outcomes, and greater…","s":"Completed","tr":["Observational"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03457714"},{"n":"NCT07733401","t":"Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury","d":"The goal of this clinical trial is to learn whether expansile duraplasty can improve neurological recovery in adult patients with acute severe traumatic spinal cord injury, as well as evaluate the safety of this surgical strategy. The main questions the study aims to answer are: 1. Does expansile duraplasty lead to superior motor function recovery in patients with acute severe traumatic spinal cord injury? 2. How safe is the use of expansile duraplasty in people with acute traumatic SCI?…","s":"Not yet recruiting","tr":["Surgical Procedure"],"o":["Motor Function","Quality of Life","Walking Function"],"st":[],"co":["China"],"lc":13,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07733401"},{"n":"NCT06892106","t":"Gut Dysbiosis in Spinal Cord Injury Rehabilitation","d":"The goal of this study is to investigate the role of gut microbiota, and related immune biomarkers and metabolites, in the functional recovery of spinal cord injury patients during the subacute phase. The main question it aims to answer is: How does gut microbiota dysbiosis impact functional recovery in subacute SCI patients, in a way that future targeted probiotic interventions may improve SCI outcomes?","s":"Completed","tr":["Nutrition","Observational","Rehabilitation"],"o":["Bowel Function","Quality of Life"],"st":[],"co":["Portugal"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06892106"},{"n":"NCT05181150","t":"Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury","d":"Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.","s":"Unknown","tr":[],"o":["Bone Strength"],"st":[],"co":["Denmark"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05181150","su":"https://scitrials.org/trial/NCT05181150"},{"n":"NCT07052344","t":"Gut-Brain Neural Coupling in Spinal Cord Injury","d":"The purpose of this research is to determine the effects of food on brain and stomach activity in persons with and without spinal cord injury (SCI).","s":"Recruiting","tr":[],"o":["Motor Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07052344","su":"https://scitrials.org/trial/NCT07052344"},{"n":"NCT06981338","t":"Guttmann NeuroRecovery - Viability, Safety, and Efficacy of Intrathecal Wharton's Jelly Mesenchymal Stem Cells and Transcutaneous Spinal Cord Stimulation in Chronic Spinal Cord Injury Rehabilitation","d":"This clinical trial primarily aims to evaluate the safety and feasibility of a combined therapeutic approach for chronic spinal cord injury (SCI). The study will investigate whether the combination of intrathecal Wharton's jelly mesenchymal stem cells and transcutaneous spinal cord stimulation (tSCS) is safe and viable in individuals with chronic traumatic SCI. The trial will enrol 10 participants aged 16-70 with traumatic SCI (cervical or thoracic levels C1-T12) classified as ASIA Impairment…","s":"Not yet recruiting","tr":[],"o":["Regeneration"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06981338","su":"https://scitrials.org/trial/NCT06981338"},{"n":"NCT00890916","t":"Hand Function for Tetraplegia","d":"The purpose of this study is to evaluate the effectiveness of an implanted stimulator for providing hand function to individuals with cervical level spinal cord injury. The device stimulates the paralyzed muscles of the hand and forearm. The user of the device controls the stimulation by moving muscles that are not paralyzed, such as a wrist or neck muscle. The ability of the user to pick up and move objects, as well as perform various activities such as eating, drinking, and writing.","s":"Completed","tr":["Devices"],"o":["Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00890916"},{"n":"NCT05128994","t":"Hand Grasp Function After Spinal Cord Injury","d":"The objective of this study is to advance personalized, portable, and non-invasive hand-grasp neuro-orthoses that restore naturalistic grasp functions for those with tetraplegia due to spinal cord injury (SCI), designed around their needs and preferences.","s":"Completed","tr":["Devices","Functional Electrical Stimulation (FES)"],"o":["Hand Movement","Mental Health","Motor Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05128994"},{"n":"NCT06213012","t":"Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury","d":"It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI). The work proposed herein will examine and identify distinct electrophysiological mechanisms underlying transcutaneous spinal stimulation (TSS) and epidural spinal stimulation (ESS) to define how these…","s":"Recruiting","tr":["Epidural Stimulation","Transcutaneous Stimulation"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06213012","su":"https://scitrials.org/trial/NCT06213012"},{"n":"NCT07030322","t":"Health and Financial Impact on the Use of a Personal Exoskeleton in the Home and Community: a Case Study","d":"The goal of this clinical trial is to examine the long-term use of a personal overground robotic exoskeleton in subjects with spinal cord injury. The main aims of this study include: 1. Determine patterns of personal overground robotic exoskeleton use over 12 months. 2. Examine the impact of personal overground robotic exoskeleton use on health outcomes over 12 months. These will include: 1. Objective health - heart rate, physical activity, sleep behavior, body temperature, body-mass index, and…","s":"Enrolling by invitation","tr":["Exoskeleton"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07030322","su":"https://scitrials.org/trial/NCT07030322"},{"n":"NCT03743077","t":"Health in Individuals With a Spinal Cord Injury: a Prospective Study","d":"Individuals with a spinal cord injury need to exercise regularly to prevent the decline of health that results from a sedentary lifestyle. The purpose of this investigation is to examine the effects of a pre-existing exercise program and respiratory training on measures of health and quality of life in individuals who elect to participate in an existing 8-week supervised exercise program.","s":"Completed","tr":["Rehabilitation"],"o":["Breathing Function","Motor Function","Quality of Life","Trunk Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03743077"},{"n":"NCT07386522","t":"Health Information for Persons With Spinal Cord Injury","d":"The goal of this pilot study is to design and feasibility test a mobile phone text messaging (SMS) self-management intervention for persons with spinal cord injury (PwSCI). The project will focus on providing a 16-week text messaging intervention on the secondary health conditions of bowel/bladder management, pain, pressure injury, and psychosocial health. Our hopes are to reduce the impact of secondary health conditions (SHC) for PwSCI. The project hopes to test whether the developed…","s":"Recruiting","tr":[],"o":["Bladder Function","Bowel Function","Pain Management","Pressure Sores","Quality of Life"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07386522","su":"https://scitrials.org/trial/NCT07386522"},{"n":"NCT00148239","t":"Health Interventions for Survivors and Primary Support Persons of Spinal Cord Injury","d":"The overall objective of this project is to test the efficacy of an innovative multi-component intervention aimed at reducing the risk for adverse health outcomes among caregivers of older survivors with spinal cord injury or disability, and to improve the well being of the spinal cord-injured survivor. In a three-group, randomized, controlled design providing access to information, resources, and support, we predict that the dual target approach will have a greater positive impact on both the…","s":"Completed","tr":[],"o":[],"st":["Florida","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00148239"},{"n":"NCT02201173","t":"Health Outcomes After Locomotor Training in Spinal Cord Injury","d":"People with spinal cord injury (SCI) suffer from secondary health conditions that can result in undue physical challenges and impact participation in activities in everyday life. Locomotor Training (LT) has been shown to demonstrate improvements in balance and walking function in both the animal and humans by reactivating spinal circuits through intensive therapy of muscles below the level of the injury. However, it is not known if LT also has beneficial health effects and it is the focus of…","s":"Completed","tr":["Rehabilitation"],"o":["Bladder Function","Blood Pressure","Breathing Function","Quality of Life","Sensory Function","Trunk Control","Walking Function"],"st":["Colorado","Kentucky","New York"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02201173"},{"n":"NCT03689023","t":"Health Promotion and Cardiovascular Risk Reduction Among People With Spinal Cord Injury","d":"This study is a controlled pragmatic implementation study in clinical practice, with a primary focus on cardiovascular risk reduction through adherence to behavioral interventions related to physical activity and healthy diet.The intervention is interdisciplinary, multimodal and patient activating and uses the existing setting and work flows at the clinic, ensuring that the patients receive education about cardiovascular risk factors, physical activity and healthy diet through a systematic…","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03689023"},{"n":"NCT05380661","t":"Heart Rate Variability and Anxiety During Urinary Bladder Catheterization","d":"This is a prospective, randomised study investigating the physical and psychological experience of intermittent catheterization in adult individuals following spinal cord injury (SCI).","s":"Completed","tr":["Devices"],"o":["Bladder Function","Blood Pressure","Mental Health"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05380661"},{"n":"NCT05982652","t":"Heart Rate Variability and Its Association With Symptom of Orthostatic Hypotension in Spinal Cord Injury","d":"In this study, the SCI patients were sub-grouped on the basis of symptoms into symptomatic and asymptomatic groups and measured HRV during resting and tilt up tests to compare their cardiovascular autonomic functions.","s":"Unknown","tr":["Observational"],"o":["Blood Pressure"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05982652","su":"https://scitrials.org/trial/NCT05982652"},{"n":"NCT03662308","t":"Heated Vest for Persons With Spinal Cord Injury","d":"Persons with higher levels of spinal cord injury (above the 2nd thoracic vertebrae; tetraplegia) are unable to maintain normal core body temperature (Tcore) when exposed to cool environments. In persons with tetraplegia, even limited exposure to cool temperatures may cause Tcore to approach hypothermic values and impair cognitive performance. Conversely, an increase in Tcore from subnormal to normal range may improve cognitive performance. Prior work has shown that cool seasonal temperatures…","s":"Completed","tr":["Devices"],"o":["Quality of Life","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03662308"},{"n":"NCT06451133","t":"Hemodynamic Management Following Acute Traumatic Spinal Cord Injury","d":"The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.","s":"Recruiting","tr":[],"o":["Blood Pressure"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06451133","su":"https://scitrials.org/trial/NCT06451133"},{"n":"NCT04075812","t":"High Definition Neuromuscular Stimulation in Tetraplegia","d":"The purpose of this study is to demonstrate high definition non-invasive neuromuscular stimulation of an upper extremity in tetraplegic participants.","s":"Completed","tr":["Devices"],"o":["Arm Movement","Motor Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04075812"},{"n":"NCT03899584","t":"High Doses of 4-aminopyridine in Clinically Complete Chronic Spinal Cord Injury Patients.","d":"150 patients with clinically complete chronic spinal cord Injury will be included in a randomized, parallel, placebo controlled, multi-centric, phase III trial. Patients will be evaluated before starting the medication, and at the end of the treatment in the locomotor, sensory, grade of independence, sensitivity and control of bladder and anal sphincters, quality of life, and psychogenic erection in males. Patients will be divided randomly into two groups where one will receive placebo and the…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Mexico"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03899584","su":"https://scitrials.org/trial/NCT03899584"},{"n":"NCT06244160","t":"High Flow Oxygen Therapy After Spinal Cord Injury","d":"The goal of this feasibility study is to learn about the ability to use a different form of oxygen therapy (known as high flow oxygen therapy) in patients who have a spinal cord injury in the upper back or neck. The main questions it aims to answer are: 1. Is it possible to recruit patients to the study 2. It is possible to follow the protocol in its current format 3. What is the impact on those receiving the intervention. Participants will be randomised to receive either standard care or high…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06244160","su":"https://scitrials.org/trial/NCT06244160"},{"n":"NCT05214378","t":"High Frequency SARS for Neurogenic Bladder and Bowel Emptying","d":"The purpose of this study is to determine if bladder emptying can be achieved using stimulation of the sacral roots at certain frequencies. Neurogenic bladder dysfunction occurs after spinal cord injury (SCI). It is a problem that often includes detrusor-sphincter-dyssynergia (DSD), which results in difficulty emptying the bladder due to reflex urethral sphincter contractions during bladder emptying. Individuals with DSD typically require a catheter to empty their bladder. Some people have…","s":"Completed","tr":["Devices","Electrical Stimulation"],"o":["Bladder Function","Bowel Function"],"st":["New York","Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05214378"},{"n":"NCT06945835","t":"High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction","d":"The Hawks in Motion (HIM) High Intensity Exercise program is designed to implement the American Physical Therapy Clinical Practice Guidelines and American College of Sports Medicine recommendations for exercise for people with neurologic disability. Doctor of Physical Therapy (DPT) students administer the HIM High Intensity Exercise Program. A prior study evaluated the feasibility, safety, and efficacy of the HIM High Intensity Exercise Program and found it feasible, safe, and effective for 30…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Trunk Control","Walking Function"],"st":["Connecticut"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06945835"},{"n":"NCT03714997","t":"High Intensity Exercise in Incomplete SCI","d":"The goal of this study is to identify the comparative efficacy of high-intensity walking training in individuals with chronic, motor incomplete spinal cord injury as compared to lower-intensity walking exercise.","s":"Completed","tr":[],"o":["Walking Function"],"st":["Indiana"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03714997"},{"n":"NCT05951985","t":"High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners","d":"Individuals with and without neurologic diagnoses greatly benefit from participation in regular exercise but the majority are physically inactive. This is an issue for both them and their care partners as their health is often linked. This study aims to examine the long-term physical and psychosocial effects of structured, group-based, high intensity functional training (HIFT) exercise for people with neurologic diagnoses and their care partners.","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Arkansas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05951985","su":"https://scitrials.org/trial/NCT05951985"},{"n":"NCT04940598","t":"High Intensity Interval Exercise SCI","d":"This study will determine if the implementation of a home-based telehealth high intensity interval exercise-training (HIIT)program can significantly improve cardiometabolic health and physical function in a cohort of individuals with longstanding spinal cord injury (SCI). Results from this study will determine feasibility, overall enjoyment, and health impact of implementing a home-based telehealth HIIT program in individuals with SCI.","s":"Completed","tr":[],"o":[],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04940598"},{"n":"NCT04973852","t":"High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation","d":"The purpose of this study is to see if it's possible to reach high cardiovascular intensity training parameters (exercise at a rate that elevates heart rate to the level recommended for improving strength and endurance) while walking in a wearable robotic exoskeleton. This study will also evaluate if exercising at high intensity will lead to improvement in walking ability. Participants in this study will be asked to attend 5 walking training sessions using Ekso exoskeleton. There will be two…","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Blood Pressure","Breathing Function","Motor Function","Trunk Control","Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04973852"},{"n":"NCT07359677","t":"High-frequency Alternating Current Stimulation for Neurophatic Pain in Spinal Cord Injury","d":"To investigate the safety and effectiveness of transcutaneous electrical stimulation with 40 kHz alternating currents combined with standard treatment compared to placebo electrical stimulation plus standard treatment for neuropathic pain in people with spinal cord injury.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Pain Management","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07359677"},{"n":"NCT04011137","t":"High-intensity Interval Training and Mixed Meal Responses in Persons With Spinal Cord Injury","d":"Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population. There is mounting evidence from the able-bodied literature that high-intensity interval training (HIIT) is more effective than moderate-intensity continuous training (MICT) at improving markers of cardiometabolic health. Before we can understand the long-term training effects of HIIT in this population, it is important to compare the acute…","s":"Completed","tr":[],"o":["Blood Pressure"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04011137"},{"n":"NCT04397250","t":"High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury","d":"Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population. There is mounting evidence from the able-bodied literature that high-intensity interval training (HIIT) is an effective way to improve cardiometabolic health outcomes, but this effect has yet to be investigated in persons with chronic paraplegia. This study is recruiting adults (aged 18-65 years) with paraplegia (T2 or below) who sustained their…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04397250","su":"https://scitrials.org/trial/NCT04397250"},{"n":"NCT07553923","t":"High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury","d":"People with incomplete spinal cord injury (SCI) often have some preserved movement and may regain walking ability, but recovery can be limited, and more effective rehabilitation approaches are needed.The goal of this clinical trial is to learn if high-intensity walking rehabilitation can improve walking recovery and overall neurological recovery in individuals with subacute SCI. The investigators are also exploring the process of incorporating this type of physical therapy approach in an…","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07553923","su":"https://scitrials.org/trial/NCT07553923"},{"n":"NCT03070431","t":"High-precision Radiotherapy of Motor Deficits Due to Metastatic Spinal Cord Compression","d":"The major goal of this clinical study is to investigate to which extent high-precision radiotherapy (RT) with modern techniques can prevent progression or recurrence of motor deficits (weakness) of the legs following RT. In addition, it will be evaluated to which extent RT can lead to improvement of motor function, ambulatory status, sensory function and sphincter dysfunction, to pain relief and to improvement in quality of life, side effects and overall survival. For this purpose 44 patients…","s":"Completed","tr":[],"o":["Motor Function","Pain Management","Quality of Life","Sensory Function","Walking Function"],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03070431"},{"n":"NCT01407705","t":"High-Resolution Diffusion Tensor Imaging (DTI) of the Cervical Spinal Cord in the Setting of Spinal Cord Injury (SCI)","d":"The investigators propose a prospective study, designed to analyze the efficacy of High-Resolution Diffusion Tensor Imaging for accurately sensing white matter tracts in subjects with spinal cord injury. Study subjects will not be randomized, as treatment will follow the doctor's \"standard of care.\" Patients will be selected and offered enrollment based upon the clinical diagnosis of spinal cord injury, either due to degenerative disease or trauma. Enrollment will be based on the chronology of…","s":"Completed","tr":["Observational"],"o":[],"st":["Utah"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01407705"},{"n":"NCT04564495","t":"Home Based Tele-exercise for People With Chronic Neurological Impairments","d":"To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04564495","su":"https://scitrials.org/trial/NCT04564495"},{"n":"NCT07264868","t":"Home Neuromodulation for Neurogenic Bladder Management in Spinal Cord Injury","d":"The purpose of this study is to determine the safety and efficacy of Injectrode Tibial Nerve Stimulation for bladder function in people with spinal cord injury.","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07264868","su":"https://scitrials.org/trial/NCT07264868"},{"n":"NCT03458871","t":"Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation","d":"Determine the safety, feasibility, compliance, and efficacy of a daily home TTNS protocol in chronic SCI provided by self or caregiver for 4 weeks.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03458871"},{"n":"NCT01882257","t":"Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury","d":"* Patients with spinal cord injury (SCI) usually breathe without any mechanical assistance, but significant breathing problems occur often during sleep, either because the upper airway closes (obstructive sleep apnea; OSA), or because of weakness/paralysis of the breathing muscles. These problems often go unrecognized, as SCI patients face logistical barriers that cause them to refuse appropriate testing in sleep laboratories. We have devised a strategy for diagnosing sleep-disordered breathing…","s":"Completed","tr":["Devices","Transcutaneous Stimulation"],"o":["Breathing Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01882257"},{"n":"NCT07438353","t":"Home-Based Digital Rehabilitation Program Optimized With Transcutaneous Spinal Cord Stimulation for Upper Limb Functional Enhancement in Tetraplegia (HOPE): A Safety, Efficacy, and Feasibility Study","d":"Individuals with chronic cervical spinal cord injury (SCI) and tetraplegia commonly experience persistent impairment in upper limb function, leading to reduced independence and quality of life. Transcutaneous spinal cord stimulation (tSCS) is a non-invasive neuromodulation technique that has demonstrated potential to improve upper limb strength and function when combined with rehabilitation. However, access to tSCS is limited in Singapore due to cost, regulatory barriers, and the need for…","s":"Not yet recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07438353","su":"https://scitrials.org/trial/NCT07438353"},{"n":"NCT07317843","t":"Home-Based Heat Therapy in Spinal Cord Injury to Improve Cardiovascular Health","d":"The study is designed to investigate the effects of passive heat therapy on blood vessel health in 40 people (48 enrolled with attrition rate of 20%). Following an extensive set of vascular function tests, participants will engage in either a passive heat therapy intervention for 60 minutes, 4 times a week for 8 weeks, or a placebo intervention at a lower temperature. Seven of the 8 weeks of intervention will occur in the home setting. Vascular function tests will be repeated after the 8 weeks…","s":"Recruiting","tr":["Observational"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07317843","su":"https://scitrials.org/trial/NCT07317843"},{"n":"NCT02118194","t":"Home/Work, Community Mobility Skills in the ReWalk Exoskeleton in Persons With SCI","d":"The overall goal of this project is to determine if non-ambulatory persons with spinal cord injury (SCI) who have already participated in at least 20 sessions of ReWalk training can be further trained to achieve more advanced skills for use in the home or work place environments and outdoor community mobility skills in the ReWalk exoskeleton.","s":"Completed","tr":["Exoskeleton","Observational"],"o":["Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02118194"},{"n":"NCT01273428","t":"HP011-101, HP828-101, and Standard Care for Pressure Ulcers","d":"Testing a drug and a device for the treatment of pressure ulcers, compared with current treatments.","s":"Withdrawn","tr":["Devices","Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01273428"},{"n":"NCT00093275","t":"HP184 in Chronic Spinal Cord Injury Subjects","d":"The purpose of this study is to determine whether HP184 is effective in the treatment of chronic spinal cord injury (CSCI).","s":"Completed","tr":["Drugs"],"o":["Motor Function"],"st":["New Jersey"],"co":["Australia","Germany","India","United Kingdom","United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00093275"},{"n":"NCT06715631","t":"Human Factors Validation Testing of the Wandercraft Personal Exoskeleton","d":"The goal of this interventional, national, prospective, open and monocentric study is to demonstrate that a personal exoskeleton can be used by the intended users without serious use errors or problems, for the intended uses and under the expected use conditions.","s":"Completed","tr":["Exoskeleton"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06715631"},{"n":"NCT04578665","t":"Human-like Robotic Controllers for Enhanced Motor Learning","d":"The purpose of this study is to develop a new paradigm to understand how humans physically interact with each other at a single and at multiple joints, with multiple contact points, so as to synthesize robot controllers that can exhibit human-like behavior when interacting with humans (e.g., exoskeleton) or other co-robots. The investigators will develop models for a single joint robot (i.e. at the ankle joint) that can vary its haptic behavioral interactions at variable impedances, and…","s":"Suspended","tr":["Exoskeleton"],"o":["Leg Movement","Motor Function","Spasticity","Trunk Control","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04578665"},{"n":"NCT05887752","t":"Hunova® Randomized Controlled Trial for Trunk Control Improvement in Spinal Cord Injured Patients","d":"In patients with Spinal Cord Injury (SCI), trunk and therefore postural control (both in statics and dynamics) are impaired, often with strong consequences on daily life activities. Therefore, improvement and reinforcement of trunk control are primary rehabilitation (rehab) goals. For the evaluation of trunk control in SCI people, still today no tests and scales are definable as gold standards. Nowadays, for evaluation and rehab purposes of trunk control, balance and proprioception, in both…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05887752","su":"https://scitrials.org/trial/NCT05887752"},{"n":"NCT04458324","t":"Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury","d":"Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI). Functional Electrical Stimulation Row Training (FESRT) couples volitional arm and electrically controlled leg exercise, resulting in the benefits of large muscle mass exercise. However, despite the potential for enhancing aerobic capacity by training the denervated leg skeletal muscle via hybrid FES exercise, the inability to increase…","s":"Active, not recruiting","tr":[],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04458324","su":"https://scitrials.org/trial/NCT04458324"},{"n":"NCT04211311","t":"Hybrid High-intensity Interval Training for Persons With Spinal Cord Injury. A Feasibility Study","d":"This study examines safety and feasibility of a study protocol using a combination of functional electrical legcycling with voluntary armwork (hybrid training) as either skiergometer or armcycling in high intensity intervals for persons with spinal cord injury paraplegia.","s":"Completed","tr":["Safety"],"o":["Pain Management","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04211311"},{"n":"NCT07648173","t":"Hybrid HIIT-FES Cycling Program on Individuals With Spinal Cord Injury to Improve Health","d":"Project Summary/Abstract Obesity and metabolic syndrome (obesity, dyslipidemia, hyperglycemia, hypertension) are epidemic in the spinal cord injured (SCI) population. A recent study assessing the body composition and metabolic syndrome rates of 72 motor complete chronic SCI individuals revealed an obesity rate of over 90% and a metabolic syndrome rate of 60%. These results are significantly higher than in the general population. As such individuals with SCI typically have systemic inflammation…","s":"Recruiting","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Blood Pressure"],"st":["Mississippi"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07648173"},{"n":"NCT02139436","t":"Hybrid-FES Exercise to Prevent Cardiovascular Declines in Acute SCI","d":"Each year, 11,000 people suffer a spinal cord injury (SCI) in the U.S. Within the first year, there are profound declines in physiologic function, forming the underlying substrate for future cardiovascular disease . In fact, acquired cardiovascular disease is an increasingly recognized consequence of SCI and is the leading cause of death in SCI. Though incompletely understood, the almost 10-fold prevalence of cardiovascular disease results in part from profound physiologic 'detraining'…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Blood Pressure"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02139436"},{"n":"NCT03112941","t":"Hyperbaric Oxygen and Orthopedic Comprehensive Treatment for Traumatic Incomplete Spinal Cord Injury in the Plateau","d":"To observe modified Barthel index, American Spinal Injury Association (ASIA) impairment scale grading, sensory score and motor score in patients with incomplete SCI in the plateau using 0.2 MPa HBO combined with pedicle screw fixation and decompressive laminectomy so as to investigate the effect of HBO therapy on incomplete SCI in the plateau.","s":"Completed","tr":["Surgical Procedure"],"o":["Motor Function","Sensory Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03112941"},{"n":"NCT03101982","t":"Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury. (EOS) - Pilot Study","d":"Hypothesis of the Study: Based on the presented results, the investigator hypothesises that HBO preserves neurons that are not irreversibly damaged (i.e. severed) during initial trauma, thus enabling regain of their function. The investigator predicts that HBO treatment protects and enhances motor function in initially paralysed regions, including improvement in function of the extremities as well as recovery of urinary bladder control and bowel function. Outline of the Proposed Study: Within a…","s":"Terminated","tr":["Drugs","Rehabilitation","Surgical Procedure"],"o":["Bladder Function","Bowel Function","Motor Function","Regeneration"],"st":[],"co":["Austria"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03101982"},{"n":"NCT05047120","t":"Hypnotic Cognitive Therapy Reduce Acute & Chronic SCI Pain in Inpatient Rehabilitation","d":"Chronic spinal cord injury (SCI) pain is complex and difficult to treat. For individuals with SCI, pain often begins early in the course of their SCI and continues longitudinally. Unfortunately, SCI-related pain is frequently not responsive to medical treatment and medical treatments that are available and commonly used, such as opioids, have negative side-effects and risk of addiction. Nonpharmacological (non-medication) interventions to reduce chronic pain show promise both for individuals…","s":"Active, not recruiting","tr":[],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05047120","su":"https://scitrials.org/trial/NCT05047120"},{"n":"NCT01739010","t":"Hypothermia Following Acute Spinal Cord Injury","d":"The purpose of this study is to investigate the long term outcome of patients who receive hypothermia treatment for spinal cord injury. At this institution, intravascular hypothermia has been used for certain patients with spinal cord injury for the past two years. This study will collect data from vital signs and examinations while the patient is in the hospital and also when they follow up as an outpatient after they are discharged or go to a rehabilitation center. This data will then be…","s":"Completed","tr":["Observational","Rehabilitation"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01739010"},{"n":"NCT02881957","t":"Hypovitaminosis D in Neurocritical Patients","d":"Vitamin D has been shown to impact prognosis in a variety of retrospective and randomized clinical trials within an intensive care unit (ICU) environment. Despite these findings, there have been no studies examining the impact of hypovitaminosis D in specialized neurocritical care units (NCCU). Given the often significant differences in the management of patients in NCCU and more generalized intensive care units there is a need for further inquiries into the impact of low vitamin D levels in…","s":"Completed","tr":["Drugs","Nutrition"],"o":["Bladder Function"],"st":["Utah"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02881957"},{"n":"NCT07002437","t":"Hypoxia Pathways for Early Recovery After Spinal Cord Injury","d":"Spinal cord injury (SCI) disrupts neural pathways to respiratory motor neurons, diminishing breathing capacity and airway defense (e.g., cough). Indeed, respiratory impairment is a leading cause of infection, re-hospitalization and death after SCI. There is a critical need for new strategies to restore breathing ability and airway defense in people with SCI. Acute intermittent hypoxia (AIH) - repetitive exposure to brief episodes of low inspired oxygen - is a promising strategy to restore…","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07002437","su":"https://scitrials.org/trial/NCT07002437"},{"n":"NCT05470478","t":"iBCI Optimization for Veterans With Paralysis","d":"VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis, spinal cord injury or stoke. In this project, the investigators enhance deep learning neural network decoders and multi-state gesture decoding for increased accuracy and reliability and deploy them on a battery-powered mobile BCI device for independent use of computers and…","s":"Not yet recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":["Quality of Life"],"st":["Rhode Island"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05470478"},{"n":"NCT05346913","t":"ICBT Program for Caregivers of Persons With SCI","d":"Spinal cord injuries have a devastating effect on individuals incurring the life changing event; however, the injury can also affect those who are integrally involved in their care. Assisting individuals after an SCI frequently falls on unpaid, family caregivers. Studies have reported that caregivers experienced significantly greater negative outcomes than positives. The most common negative outcome factors were high levels of burden, poor adjustment to role, decreased QOL, emotional distress…","s":"Unknown","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05346913"},{"n":"NCT04902482","t":"iCycle II: Recovery of Function Through FES Cycling With VR Biofeedback in People With SCI.","d":"The annual incidence of traumatic spinal cord injury (SCI) is estimated at 2,500 (35 per week) in the UK and, due to advances in research and clinical management, the majority now have incomplete injuries, with significant potential for neurological improvement. Discovering ways to provide intensive, but cost-effective SCI rehabilitation is therefore increasingly important. The iCycle combines functional electrical stimulation (FES) cycling with VR cycle-racing feedback, where winning…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04902482","su":"https://scitrials.org/trial/NCT04902482"},{"n":"NCT03249129","t":"Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord Trauma","d":"The purpose of the study is to detect the presence of autoantibodies and autoantigens in cerebrospinal fluid early (\\<48 hours) following spinal cord trauma. The study also aims to define the central or peripheral origin of autoantibodies by looking for their simultaneous presence at the blood level and to evaluate the prognostic value of the presence of autoantibodies within the cerebrospinal fluid, as well as on the initial clinical severity than on the recovery potential.","s":"Withdrawn","tr":["Observational"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03249129"},{"n":"NCT06532760","t":"Identification of Sodium Channel Fragments as Serum Biomarkers of a Traumatic Central Nervous System Injury","d":"Following spinal cord injury (SCI), 75% of patients develop spasticity of the limbs characterized by an increase in muscle tone causing severe pain. Currently, the diagnosis of spinal cord injury is based on clinical and radiological evaluation by CT and MRI, but there is no reliable biomarker capable of predicting the medium and long-term clinical course in terms of emergence and severity of spasticity and neurological recovery. Recently, pre-clinical models in rats have shown the presence of…","s":"Not yet recruiting","tr":[],"o":["Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06532760","su":"https://scitrials.org/trial/NCT06532760"},{"n":"NCT02104622","t":"Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation","d":"Many people with spinal cord injury are no longer able to walk and must use wheelchairs for mobility. These individuals experience greater rates of depression and lower quality of life. Many of these individuals express a strong desire to walk again, and report many psychosocial benefits to being eye to eye with peers in social interactions. Additionally, wheelchairs allow only limited community access, creating an additional obstacle to seeking out meaningful social roles in the community…","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life","Trunk Control","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02104622"},{"n":"NCT04706208","t":"Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury","d":"Many adults with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain. Available treatments, including opioids, are ineffective at eliminating this pain. Based on preliminary data from Dr Morse and from Dr Van de Winckel, we have demonstrated that brain areas that are important for body awareness and pain perception (parietal operculum, insula) have weaker brain connectivity in adults with spinal cord injury than in able-bodied healthy adults and that Cognitive…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Pain Management"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04706208"},{"n":"NCT03875066","t":"Immediate Effects of Stepping Training Using External Feedback in Spinal Cord Injury Patients","d":"* Does stepping training with or without external feedback change functional ability of ambulatory patients with iSCI immediately after training? * Are there significant differences between the immediate effects of stepping training with or without external feedback in ambulatory patients with iSCI?","s":"Completed","tr":[],"o":["Leg Movement","Motor Function","Trunk Control","Walking Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03875066"},{"n":"NCT04700033","t":"Immersive Virtual Reality for Chronic Neuropathic Pain After Spinal Cord Injury: A Feasibility Trial","d":"The aim of this study is to provide critical information about the efficacy of Immersive Virtual Reality (IVR) to decrease the experience of neuropathic pain in the upper and lower extremities of people with a spinal cord injury.","s":"Completed","tr":["Devices"],"o":["Mental Health","Pain Management","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04700033"},{"n":"NCT04049994","t":"Immunomodulation Therapy for Urinary Tract Infections","d":"Urinary tract infections (UTI) represent one of the most common morbidities in individuals with spinal cord injury (SCI) and reason for re-hospitalization. The consequences of recurrent UTI are a decrease in quality of life and considerable health costs. Immunomodulation therapy with UroVaxom is a very promising method for the prevention of UTI, however data in individuals with SCI are very limited. The primary objective of this pilot study is to evaluate the feasibility (recruitment rate…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04049994"},{"n":"NCT01984476","t":"Impact of Age on Cardiovascular, Cerebrovascular and Cognitive Health in Spinal Cord Injury","d":"As the spinal cord injured population ages, these individuals are being exposed to an increased prevalence of age-associated diseases, which coupled with the secondary complications of the injury may contribute to the reduced life expectancies. Decentralized autonomic regulation in persons with SCI results in a multitude of cardiovascular changes, which may contribute to accelerated aging. Adverse cardiovascular changes may have deleterious effects on cerebral blood flow dynamics and an…","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01984476"},{"n":"NCT03004144","t":"Impact of Assistive Forces on Activities of Daily Living","d":"This study is a cross-sectional study investigating the impact of assistive forces applied by the body-weight support system \"the FLOAT\" on the study participants. The study is conducted at the University Hospital Balgrist in Zurich over a period of around 3 years. During this time measurements on approximately 140 able bodied subjects and 60 patients with an incomplete spinal cord injury will take place. The study participants are invited for a single visit of around 140 min duration to the…","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03004144","su":"https://scitrials.org/trial/NCT03004144"},{"n":"NCT03567239","t":"Impact of Custom Assistive and Adaptive Technology in Rehabilitation","d":"Madonna's Rehabilitation Engineering Center of Excellence (REC) is continually developing custom devices for persons with disabilities. These devices are created to improve the independence of individuals living with disabilities at Madonna Rehabilitation Hospitals and in the community. The purpose of this study is to investigate the impact custom assistive and adaptive devices have on patient independence, quality of life, and experience at Madonna Rehabilitation Hospitals.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Nebraska"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03567239"},{"n":"NCT05670288","t":"Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury","d":"The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline \\[within 6 weeks of injury\\], 6, and 12 months after SCI. Stool will be collected for gut microbiome analysis 3 times.","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05670288","su":"https://scitrials.org/trial/NCT05670288"},{"n":"NCT03752749","t":"Impact of Intermittent Hypoxia and Prednisolone on Motor Performance in Persons With SCI","d":"The objective of this study is to examine the effects of mild acute intermittent hypoxia (AIH) in combination with an anti-inflammatory drug (i.e. prednisolone) on motor performance in persons with spinal cord injury (SCI).","s":"Completed","tr":["Drugs","Intermittent Hypoxia"],"o":["Motor Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03752749"},{"n":"NCT04971408","t":"Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury","d":"SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors that contribute to both heart disease and diabetes. While exercise can help reduce these risk factors, paralysis and impaired accessibility often precludes exercise in persons with SCI. New research in able-bodied persons demonstrates passive heating decreases…","s":"Completed","tr":[],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04971408"},{"n":"NCT05646810","t":"Impact of Peripheral Afferent Input on Central Neuropathic Pain","d":"The overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05646810","su":"https://scitrials.org/trial/NCT05646810"},{"n":"NCT02136823","t":"Impact of Persistent Conductances on Motor Unit Firing in SCI","d":"This study is being done to measure the differences between the electrical activity of muscles and /single muscle fibers in individuals with long-term spinal cord injury and neurologically intact individuals without spinal cord injury. This study is also being done to find out if muscle and /single muscle fiber electrical activity, voluntary strength, reflex measurements, and/or spasms are changed after a single, oral dose of three commonly prescribed drugs, Rilutek®, isradipine, and Namenda®…","s":"Unknown","tr":["Drugs"],"o":["Motor Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02136823","su":"https://scitrials.org/trial/NCT02136823"},{"n":"NCT02748356","t":"Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB","d":"As a collaborative effort between MedStar National Rehabilitation Hospital (NRH), Children's National Medical Center (CNMC) Department of Urology, Children's Research Institute (CRI) Center for Genetic Medicine Research, Georgetown University, and MedStar Georgetown University Hospital, the overall objective of this study is to develop, validate, and assess a patient-initiated, probiotic-based, selfmanagement protocol that is initiated at the time of urinary symptoms. The self-management…","s":"Completed","tr":["Drugs","Nutrition","Rehabilitation"],"o":["Bladder Function","Quality of Life"],"st":["District of Columbia"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02748356"},{"n":"NCT02748317","t":"Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB","d":"As a collaborative effort between MedStar National Rehabilitation Hospital (NRH)/MedStar Health Research Institute (MHRI), Children's National Medical Center (CNMC) Department of Urology, Children's Research Institute (CRI) Center for Genetic Medicine Research, and Georgetown University Medical Center, the overall objective of this study is to develop, validate, and assess a patient-initiated, probiotics-based, self management protocol that is initiated at the time of urinary symptoms. The…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Bladder Function","Quality of Life"],"st":["District of Columbia"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02748317"},{"n":"NCT00281463","t":"Impact of Pushrim Activated Power Assist Wheelchairs on Mobility Among People With Tetraplegia","d":"The purpose of this three phase study is to evaluate a Pushrim Activated Power Assist Wheelchair (PAPAW). Phase I will examine whether the steady-state, metabolic energy efficiency for propelling a manual wheelchair with and without the device will be significantly different. In Phase II, wheelchair users will evaluate the PAPAW over activities of daily living course to determine its usability and acceptability and to identify areas for future development. Finally, in phase III, comparison of…","s":"Completed","tr":["Devices"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00281463"},{"n":"NCT07674511","t":"Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","d":"The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury. The main questions this study attempts to solve: 1. What are the immediate effects of spinal cord transcutaneous stimulation on BP? 2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?","s":"Not yet recruiting","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Blood Pressure","Quality of Life"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07674511"},{"n":"NCT07429188","t":"Impact Study on Users of Upper Limb Assistive Devices","d":"This impact study of upper limb (UL) assistance devices is part of the Exploratory PEPR O2R \"Robotic assistance for human movements.\" The integrated project PI3 \"ASSISTMOV,\" composed of a multidisciplinary team in engineering and Human and Social Sciences (HSS), targets the use case of employing robotic assistance for the movement of persons with disabilities (PWD). Through the development of a range of exoskeletons (lower and upper limbs), this project aims for a breakthrough technology…","s":"Recruiting","tr":["Devices"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["France"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07429188","su":"https://scitrials.org/trial/NCT07429188"},{"n":"NCT06965127","t":"Implant for Walking After Incomplete SCI","d":"This is a device study that will evaluate the effect of an implanted stimulator on improving walking in people with incomplete spinal cord injury. There are two phases in the study: 1) Screening - this phase determines if the individual is a good candidate to receive an implanted system, 2) Implantation, controller development, and evaluation - this phase includes implanting the device and setting the individual up for system use, creating controllers for walking, and evaluating the effect of…","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06965127","su":"https://scitrials.org/trial/NCT06965127"},{"n":"NCT07784088","t":"Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia","d":"Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.","s":"Recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":["Mental Health","Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07784088"},{"n":"NCT07603752","t":"Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study","d":"This is a prospective, open-label, multi-center, single-arm study to evaluate the efficacy and safety of an implantable wireless brain-machine interface (BMI) system in patients with spinal cord injury. Eligible participants will undergo screening after signing informed consent, followed by BMI system implantation. Follow-up visits will be conducted postoperatively to assess brain-control performance and safety.","s":"Recruiting","tr":["Brain Machine Interface (BMI)"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07603752","su":"https://scitrials.org/trial/NCT07603752"},{"n":"NCT00623948","t":"Implanted Gluteal Stimulation System for Pressure Sore Prevention","d":"This project will evaluate the feasibility of using a fully implanted gluteal stimulation system for the prevention of Pressure ulcers. The specific goal of this study will be a pilot clinical trial of veterans with reduced mobility in order to establish clinical efficacy of a 2-channel bilateral gluteal stimulation system. A two-arm crossover study of wheelchair users with complete SCI will be carried out. All study participants will receive a fully implanted system incorporating implanted IM…","s":"Withdrawn","tr":["Transcutaneous Stimulation"],"o":["Pressure Sores"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00623948"},{"n":"NCT00583804","t":"Implanted Myoelectric Control for Restoration of Hand Function in Spinal Cord Injury","d":"The purpose of this study is to evaluate the effectiveness of an implanted stimulator and sensor for providing hand and arm function for individuals with cervical level spinal cord injury.","s":"Active, not recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00583804","su":"https://scitrials.org/trial/NCT00583804"},{"n":"NCT04493606","t":"Implementation of the ProACTIVE Toolkit in the Hospital and Community Setting","d":"There is a significant drop in physical activity among people with spinal cord injury in the months following discharge from rehabilitation. The ProACTIVE toolkit is a guide to promote physical activity to clients with spinal cord injury that has demonstrated potential to help address this sensitive time frame for physical inactivity. The toolkit was co- developed with 300 physiotherapists, community members with spinal cord injury, and university researchers and has been shown to improve…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04493606","su":"https://scitrials.org/trial/NCT04493606"},{"n":"NCT06529094","t":"Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic","d":"Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at high risk of pressure injury (PrI) throughout their lives due to loss of sensation, nerve damage and immobility. PrIs are local areas of damage to the skin and underlying soft tissue caused by pressure and shear commonly located over bony prominences. While most PrIs are hospital- or nursing home-acquired, in people…","s":"Recruiting","tr":["Observational"],"o":["Pressure Sores"],"st":["California","Florida","Illinois","Missouri","Ohio","Texas"],"co":["United States"],"lc":7,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT06529094","su":"https://scitrials.org/trial/NCT06529094"},{"n":"NCT02991248","t":"Improve Dynamic Lateral Balance of Humans With SCI","d":"This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI. One group will receive pelvis perturbation training paired with tsDCS, one group will receive pelvis perturbation training paired with sham, and one group will receive treadmill training only.","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02991248","su":"https://scitrials.org/trial/NCT02991248"},{"n":"NCT05903859","t":"Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)","d":"This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.","s":"Recruiting","tr":[],"o":["Sexual Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05903859","su":"https://scitrials.org/trial/NCT05903859"},{"n":"NCT06691165","t":"Improving 24-hour Blood Pressure Stability in Spinal Cord Injury With Low Oxygen Therapy","d":"This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury. This study will examine if brief episodes of breathing lower oxygen, termed low oxygen therapy (LOT), which has been shown to enhance autonomic nervous system activity, can improve blood pressure stability in individuals with spinal cord injury. The research team will assess 24-hour blood pressure, as well as cardiac, vascular, and autonomic…","s":"Recruiting","tr":[],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06691165","su":"https://scitrials.org/trial/NCT06691165"},{"n":"NCT04408287","t":"Improving Activity Engagement Among Persons With SCI During COVID-19","d":"During the current COVID-19 pandemic many spinal cord injury (SCI) rehabilitation services are limited to emergency management, leaving those living in the community without access to services. Unfortunately, this can lead to negative effects including increase in emotional distress, feelings of isolation, and decreased activity engagement. Due to their limited mobility and greater likelihood of respiratory illness it is imperative to provide alternative forms of activity engagement to reduce…","s":"Completed","tr":["Rehabilitation"],"o":["Breathing Function","Mental Health","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04408287"},{"n":"NCT05424172","t":"Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching","d":"The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding health apps preferences for optimal consumer use, (2) conducting a usability study of the customized app to determine the quality and implement further changes for optimization, and (3) conducting a…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05424172","su":"https://scitrials.org/trial/NCT05424172"},{"n":"NCT01570816","t":"Improving Ambulatory Community Access After Paralysis","d":"The purpose of this research study is to evaluate the effectiveness of functional electrical stimulation (FES) provided by an implanted pulse generator (IPG) in correcting hip, knee and ankle function to improve walking in people with partial paralysis.","s":"Unknown","tr":[],"o":["Walking Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01570816","su":"https://scitrials.org/trial/NCT01570816"},{"n":"NCT06650202","t":"Improving Balance After Spinal Cord Injury Using a Robotic Upright Stand Trainer and Spinal Cord Epidural Stimulation","d":"The purpose of this study is to understand how standing and sitting balance control is altered after spinal cord injury and how a new type of robotic assistive device may be used with spinal stimulation to improve muscle function. The investigators will be testing a device called the Tethered Pelvic Asist Device (or \"TPAD\") in this study. The TPAD may be helpful in two ways. It can be used to help control and support of the trunk, pelvis, and knees during stand training. Also, the TPAD can be…","s":"Recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":["Walking Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06650202","su":"https://scitrials.org/trial/NCT06650202"},{"n":"NCT02331979","t":"Improving Bladder Function in SCI by Neuromodulation","d":"This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02331979","su":"https://scitrials.org/trial/NCT02331979"},{"n":"NCT03949660","t":"Improving Bowel Function and Quality of Life After Spinal Cord Injury","d":"Bowel dysfunction is consistently rated as one of the most common complications affecting daily life for individuals with spinal cord injury. The overall objective of this study is to investigate whether the use of specific spinal cord epidural stimulation will affect bowel function. This study will also examine how alterations in bowel function influence quality of life outcomes. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries…","s":"Unknown","tr":["Epidural Stimulation"],"o":["Bowel Function"],"st":["Kentucky"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT03949660","su":"https://scitrials.org/trial/NCT03949660"},{"n":"NCT02561676","t":"Improving Functioning in Persons With Chronic Pain Post-SCI Through Virtual Classroom Education","d":"Chronic pain (pain that is that is present for a long period of time) is very common among people with spinal cord injury (SCI). The purpose of this study is to compare how well two different web-based education programs reduce the level to which chronic pain interferes with daily activities and well-being.","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02561676"},{"n":"NCT00060983","t":"Improving Gait in Patients With Spinal Cord Injuries","d":"This study is part of a larger clinical trial that examines the potential of a 12-week treadmill-training program to improve walking in patients with spinal cord injuries (SCIs). Patients in the trial are at least 1 year past their injury. This substudy tests a combination of two strategies to enhance the treadmill training program: electrically stimulating a muscle withdrawal reflex and providing body weight support by partially suspending patients as they walk on the treadmill.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00060983"},{"n":"NCT03011099","t":"Improving Gait Performance in Individuals With Spinal Cord Injuries: an Intervention Using Robotic Exoskeletons","d":"The purpose of this study is to investigate whether robotic exoskeleton training can improve walking performance after SCI as compared to conventional physical therapy.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Leg Movement","Motor Function","Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03011099"},{"n":"NCT05976087","t":"Improving Grasp Function in People With Sensorimotor Impairments by Combining Electrical Stimulation With a Robotic Hand Orthosis","d":"Hand motor and sensory impairments resulting from neurological disorders or injuries affect more than 50 million individuals worldwide. Conditions such as stroke, spinal cord injury (SCI), and traumatic brain injury (TBI) can cause long-term hand impairments, greatly impacting daily activities and social integration. Since traditional physiotherapy has limited effectiveness in rehabilitation, assistive devices helping in performing in daily activities have emerged as a necessary solution. Soft…","s":"Active, not recruiting","tr":[],"o":["Hand Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05976087","su":"https://scitrials.org/trial/NCT05976087"},{"n":"NCT01143597","t":"Improving Hand and Arm Function After Spinal Cord Injury (SCI)","d":"The long-term goal of this project is to develop rehabilitation strategies that facilitate optimal restoration of skilled hand use in individuals with spinal cord injury (SCI). The objective of the studies proposed in this application is to determine whether a protocol of massed practice + somatosensory stimulation (MP+SS) is more effective for improving skilled hand use compared to a somatosensory stimulation (SS) alone, and to determine whether these approaches are each more effective than…","s":"Completed","tr":["Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01143597"},{"n":"NCT03954496","t":"Improving Hand Recovery With Neuromodulation in Tetraplegia","d":"This study will examine a form of non-invasive brain stimulation applied with intensive therapy of the arm and hand. The goal of the study is to determine if arm and hand function can be improved in people with incomplete cervical spinal cord injury (neck spinal cord injury, tetraplegia). Participants will be assigned to receive either active or inactive non-invasive brain stimulation.","s":"Terminated","tr":["Electrical Stimulation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03954496"},{"n":"NCT06690372","t":"Improving Heart Health in Individuals With SCI Using Home-Based Virtual Gaming","d":"What is the ultimate applicability of the research? Individuals with SCI face several challenges when trying to engage in exercise following injury. Barriers to engagement include cost, transportation, and lack of SCI accessible resources. At the same time, individuals with SCI are at risk of developing negative health consequences (e.g., cardiovascular disease) associated with physical inactivity. A critical need exists to improve relevant, accessible, and sustainable home-based exercise…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06690372","su":"https://scitrials.org/trial/NCT06690372"},{"n":"NCT05659121","t":"Improving Mobility Via Robotic Exoskeletons in Local Rehabilitation Settings in Singapore","d":"The programme is designed to investigate the application of robotic exoskeleton in different levels of local rehabilitation facilities. Feasibilities, efficacy, cost-effectiveness, patient and therapist's view of the application of robotic exoskeleton will be evaluated.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Singapore"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05659121"},{"n":"NCT01915095","t":"Improving Motor Function After Spinal Cord Injury","d":"The goals of this study are to examine the physiology of Central Nervous System pathways contributing to the control of upper and lower extremity movements after SCI, and to promote the recovery of extremity movements by using non-invasive brain stimulation and motor training.","s":"Completed","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement","Leg Movement","Motor Function"],"st":["Florida","Illinois","Pennsylvania"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01915095"},{"n":"NCT06515223","t":"Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury","d":"The investigators will recruit up to 20 volunteers with chronic, supra-sacral SCI. Following screening, eligible participants will enter 'Phase I', they will complete baseline outcome measures and then have the epidural spinal cord stimulator (eSCS) implanted with either percutaneous or paddle electrodes. Preoperative and intraoperative testing will determine exact location of electrodes. Mapping and optimisation of stimulation parameters will be performed simultaneously with urodynamic…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Bladder Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06515223","su":"https://scitrials.org/trial/NCT06515223"},{"n":"NCT03892746","t":"Improving SCI Rehabilitation Interventions by Retraining the Brain","d":"The Long-term goal of this project is to develop upper limb rehabilitation interventions that can be utilized for cervical Spinal Cord Injury survivors. This Study will utilize a novel method of non-invasive brain stimulation in conjunction with upper limb training given for 15 sessions over several weeks up to 8 weeks. The Study will include the following site visits: * Eligibility Screening and Informed Consent Visit. * Four testing visit in which motor function of the upper limb and…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["New Jersey","Ohio"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03892746"},{"n":"NCT03140501","t":"Improving Self-Management Skills Among People With Spinal Cord Injury","d":"The goal of our study is to evaluate the use of a self-management application (\"app\") that the investigators have developed to help facilitate self-management among individuals with SCI who live in the community. The main purpose is to create and fulfill individual self-management goals. Other purposes include improving self-management and health conditions related to SCI. During the initial phase, participants (SCI clinicians and patients with SCI) reported positive usage of the…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03140501","su":"https://scitrials.org/trial/NCT03140501"},{"n":"NCT01539109","t":"Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation","d":"The purpose of this study is to investigate whether combining a noninvasive method of brain stimulation, called Transcranial Direct Current Stimulation (tDCS), enhances the effect of training of the affected upper limbs in patients with incomplete Spinal Cord Injury.","s":"Completed","tr":["Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01539109"},{"n":"NCT05191121","t":"Improving Upper Extremity Function and Trunk Stability After Cervical Spinal Cord Injury (SCI)","d":"Ninety-nine individuals meeting the study's inclusion/exclusion criteria will be enrolled in this study. The objective of this study is to evaluate three different therapeutic approaches to synergistically retrain functional movement patterns of the upper extremities in combination with trunk stabilization to promote neurologic and functional recovery after SCI. Each subject will complete 40 sessions of intervention. Subjects will also complete a Baseline Evaluation (week 0), Re-Evaluation…","s":"Enrolling by invitation","tr":[],"o":["Hand Movement"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05191121","su":"https://scitrials.org/trial/NCT05191121"},{"n":"NCT05041322","t":"Improving Ventilatory Capacity in Those With Chronic High Level SCI","d":"The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.","s":"Completed","tr":[],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05041322","su":"https://scitrials.org/trial/NCT05041322"},{"n":"NCT07223710","t":"Improving Walking After Spinal Cord Injury","d":"Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI. Although studies have shown that locomotor training improves locomotor function in people with chronic SCI, the benefits remain limited. Our overall hypothesis is that we can engage additional descending motor pathways, such as the reticulospinal tract (RST), to…","s":"Not yet recruiting","tr":["Electrical Stimulation","Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07223710","su":"https://scitrials.org/trial/NCT07223710"},{"n":"NCT03244098","t":"In-Home Adjustment of New Spinal Cord Injury Caregivers","d":"To improve spinal cord injury (SCI) rehabilitation through stronger informal caregiving, the proposed study will modify and evaluate a telehealth Transition Assistance Program (TAP) for informal caregivers of individuals with SCI during the transition from hospital to home. The TAP was previously developed for stroke caregivers and has been found to decrease caregiver strain and depression. In the proposed study, the TAP will be modified for SCI and implemented at a state-of-the-art SCI…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03244098"},{"n":"NCT00656149","t":"In-home Telerehabilitation for Quadriplegic Hand Function","d":"1. To evaluate improvements in hand function in stable, cervical spinal cord injured (SCI) subjects treated with functional electrical stimulation (FES)-assisted exercise; 2. To compare the information obtained from existing qualitative and quantitative hand function tests with newly developed tests of sensorimotor performance. Hypotheses: 1. the performance of tasks representative of activities of daily living (ADL) will improve with daily tele-supervised exercise of the affected hand. 2. The…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00656149"},{"n":"NCT04273347","t":"Incidence of Neurogenic Paraosteoarthropathies in a Population of Brain Traumatized and Spinal Cord Injured Patients and Specific Markers of Early NPOA Development\"","d":"Neurogenic paraosteoarthropathies are peri-articular bone formations that may occur as a result of central neurological injury. Their occurrence limits reeducation and recovery capacities. Neurogenic paraosteoarthropathies sometimes cause complications (pain, joint stiffness, vascular and nerve compression, pressure sores) in patients already suffering from severe neurological sequelae affecting functional prognosis. A lot of clinical research work has been carried out within Dr Salga team…","s":"Unknown","tr":["Observational"],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04273347"},{"n":"NCT01297647","t":"Incidence of Urinary Tract Infection After Urodynamic Investigation","d":"The purpose of this study is to evaluate the incidence of urinary tract infection after urodynamic investigation and to identify the involved germs.","s":"Completed","tr":[],"o":["Bladder Function","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01297647"},{"n":"NCT05653206","t":"Incomplete Cervical SCI Without Instability","d":"A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of additional core and optional outcome assessments in cervical SCI patients to capture the aspects of neurologic impairment. Baseline, intraoperative, and postoperative characteristics, including demographics, injury details, treatment details, neurological…","s":"Active, not recruiting","tr":["Observational","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Pain Management","Trunk Control","Walking Function"],"st":["California","Maryland","Wisconsin"],"co":["Brazil","Canada","Germany","India","Portugal","United States"],"lc":10,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05653206","su":"https://scitrials.org/trial/NCT05653206"},{"n":"NCT05952700","t":"inContAlert: Machine Learning Algorithms for Individual Bladder Filling Level Prediction","d":"The aim of this study is to evaluate the bladder filling level of the study participants using the inContAlert sensor. The generated data will be used for the evaluation and optimization of the machine learning algorithms to be able to make precise predictions about the individual bladder fill level. In particular, the hypothesis that the bladder filling level can be estimated by the algorithm will be tested. When testing the hypothesis, it should be determined which deviation (measured by the…","s":"Completed","tr":["Devices","Observational"],"o":["Bladder Function"],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05952700"},{"n":"NCT02793635","t":"Indego Exoskeleton After SCI","d":"The purpose of this study is to assess the use of Indego as a gait training tool for subjects with complete or incomplete paraplegia as a result of spinal cord injury (SCI) who have preserved lower extremity function. It is hypothesized that subjects with complete or incomplete paraplegia who have preserved their lower extremity function will experience functional improvements after gait training with the Indego exoskeleton. Subjects will complete a total of fifteen (15) sessions which include…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Leg Movement","Quality of Life","Walking Function"],"st":["New York","Texas","Virginia"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02793635"},{"n":"NCT02202538","t":"Indego® Exoskeleton; Assessing Mobility for Persons With Spinal Cord Injury (SCI).","d":"This study will evaluate the Indego® device for safety and effectiveness at allowing persons with SCI who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Quality of Life","Walking Function"],"st":["Colorado","Georgia","Illinois","New Jersey","New York"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02202538"},{"n":"NCT04064957","t":"Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury","d":"HBSCI02: This protocol is part of an FDA Individual Patient Non-emergency Expanded Access Request submitted on behalf of a 38-year-old father and husband who on August 4, 2017 at about 4:30pm, slipped off a boat head-first while in the Florida Keys for a family wedding, and was immediately unable to move his legs. He discharged to Texas via air ambulance for physical rehabilitation on August 23, 2017 with a diagnosis of ASIA B (American Spinal Injury Association) C-5 SCI (spinal cord injury)…","s":"No longer available","tr":["Drugs","Rehabilitation","Stem Cells"],"o":["Sensory Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04064957"},{"n":"NCT03925649","t":"Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Treatment of SCI","d":"This study is expanded access to an Investigational New Drug (IND) for an individual patient with spinal cord injury (SCI) at cervical spine 5-6 (C 5-6) designed to provide access to autologous adipose-derived mesenchymal stem cells (HB-adMSCs)","s":"No longer available","tr":["Drugs","Stem Cells"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03925649"},{"n":"NCT07303582","t":"Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities","d":"Spasticity is an umbrella term for impairments of muscle tone and control in people with damage to the brain and spinal cord. It is highly prevalent and results in pain, stiffness, and contribute to difficulties in activities of daily living. Current treatment options are limited, and many people experience only partial reduction in spasticity and frequent repeated treatments are needed. Cryoneurolysis is a medical technique which involves the controlled freezing of the nerves. It has been…","s":"Recruiting","tr":[],"o":["Pain Management","Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07303582","su":"https://scitrials.org/trial/NCT07303582"},{"n":"NCT02083328","t":"Influence of Caffeine on HRV and Exercise Performance in Spinal Cord Injury","d":"The aim is to investigate the influence of caffeine on heart rate variability and on performance in a 3 min exercise test in different population groups (able-bodied, paraplegic and tetraplegic subjects). In general, the investigators are interested in the differences between the heart rate variability before and after caffeine supplementation and if the subjects exercise performance is enhanced using this type of supplementation. Another objective is to see whether there are differences…","s":"Completed","tr":["Nutrition"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02083328"},{"n":"NCT06214208","t":"Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury","d":"The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury. The spinal stimulation consists of electrical stimulation applied through one electrode over the skin of the lower back and two electrodes over the stomach. Testing will include participating in measurements before the intervention, during intervention, and immediately after the…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Pain Management","Spasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06214208","su":"https://scitrials.org/trial/NCT06214208"},{"n":"NCT04243044","t":"Influence of Transcutaneous Spinal Stimulation Intensity on Spasticity After SCI","d":"Transcutaneous spinal stimulation (TSS) is a form of electrical stimulation delivered over the skin of the spine that may be valuable for reducing spasticity without the side effects of antispasticity medications. The intensity of stimulation, or dose, that promotes the best response is not known. Understanding the response to different intensities of stimulation and how they affect spasticity will help guide rehabilitation for persons with SCI. Therefore, this study aims to identify the…","s":"Completed","tr":["Drugs","Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Spasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04243044"},{"n":"NCT04020770","t":"Influence of Upper Extremity Vibration on Spasticity and Function in Persons With Tetraplegia","d":"Vibration therapy is a possible alternative to drug-based treatments for spasticity following SCI. Research indicates that it may provide temporary relief from spasticity, but many interventions under investigation are not portable and therefore access is limited. The aim of this study is to investigate the feasibility of using a portable vibrating device to decrease UE spasticity.","s":"Completed","tr":["Devices","Drugs"],"o":["Arm Movement","Hand Movement","Motor Function","Spasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04020770"},{"n":"NCT04130295","t":"Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury","d":"Spasticity is muscle spasms, bouncing (clonus) or stiffness that can negatively impact the quality of life of people with spinal cord injury (SCI). In people with spinal cord injury, spasticity can limit muscle control of the arms and hands and cause pain, discomfort, and frustration. Transcutaneous electrical stimulation has been shown to reduce spasticity after SCI. However, this type of stimulation's effects during prolonged, at-home use has not been well studied. Additionally, traditional…","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Pain Management","Quality of Life","Spasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04130295"},{"n":"NCT02736890","t":"Injecting Botulinum Toxin A Underneath the Skin to Treat Spinal Cord Pain in Patients With Spinal Cord Injury","d":"Back pain is a common secondary condition of both acute and chronic spinal cord injury (SCI). Current existing treatment including both pharmacologic and non-pharmacologic are limited by marginal efficacy or intolerable side effects. The purpose of this study is to evaluate the potential of subcutaneous injections of botulinum toxin A to provide pain relief in spinal cord injury patients with back pain near the level of injury in the spine. Botulinum toxin A has been shown in both pre-clinical…","s":"Terminated","tr":["Drugs"],"o":["Mental Health","Pain Management"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02736890"},{"n":"NCT02721615","t":"Injured Spinal Cord Pressure Evaluation","d":"About a thousand people a year in the United Kingdom survive a spinal cord injury but are left paralysed or wheelchair-bound. The annual cost of care for spinal cord injury victims is more than half a billion pounds. We propose that after spinal cord injury, cord pressure at the injury site rises, damaging the spinal cord further by secondary ischaemia. The value of measuring and reducing cord pressure after spinal cord injury is unknown. The injured spinal cord is compressed by bone…","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02721615","su":"https://scitrials.org/trial/NCT02721615"},{"n":"NCT07640711","t":"Innovative Brain-Computer Interface for People With Spinal Cord Injury","d":"The goal of this clinical trial is to demonstrate control of digital devices through a brain implant in people with spinal cord injury. The main question it aims to answer is efficient, independent, BCI-based control over digital devices in settings of daily living of an individual with SCI. In this project an advanced generation fully implantable BCI system will be used, the Brain InterChange (BIC) from CorTec. Participants will be implanted with an electrode grid on the surface of the brain…","s":"Recruiting","tr":["Brain Machine Interface (BMI)"],"o":["Quality of Life"],"st":[],"co":["Netherlands"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07640711","su":"https://scitrials.org/trial/NCT07640711"},{"n":"NCT02891096","t":"Inspiratory Strength and Respiratory Complications After SCI Injury","d":"The investigators conducting this study to investigate the relation between the respiratory muscle strength and respiratory complications. To understand more about respiratory complications the influence of different factors (such as in- and expiratory muscle strength, lung function parameters, physical activity, smoking, medications,…) on respiratory complications (such as pneumonia) will be investigated.","s":"Completed","tr":["Observational"],"o":["Breathing Function","Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02891096"},{"n":"NCT03069404","t":"INSTrUCT-SCI: INdependent Observational STUdy of Cell Transplantation in SCI","d":"The investigation is a multi-year observational study following the completion of the open-label, single dose Phase I/II study involving transplantation of allogeneic HuCNS-SC cells into 12 subjects with thoracic spinal cord injury. Subjects will be monitored at routine intervals for safety and preliminary efficacy for 5 years post-transplantation of the Phase I/II investigation CL-N02-SC.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03069404"},{"n":"NCT05360719","t":"Integrated Tele-exercise for Individuals With Spinal Cord Injury","d":"The objective of this study is to examine the efficacy of an integrated, participant-centered tele-health physical activity program for individuals with SCI on psychological and social factors through a parallel mixed-methods design approach. We will examine changes in psychological (self-efficacy, self-esteem, exercise outcome expectations, depression, positive affect and well-being, quality of life) and social factors (participation and satisfaction with social roles and activities, activity…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05360719","su":"https://scitrials.org/trial/NCT05360719"},{"n":"NCT04302259","t":"Intelligent Spine Interface, Clinical (ISI-C)","d":"This research study is being done to test a new device developed for spinal cord injury (SCI) patients. The purpose of this study is to collect data on how the nervous system signals travel within the spinal cord of SCI patients. Once the investigators understand that, they hope to develop a device that may help rehabilitation of SCI patients so that they can regain function in their lower limbs. This study involves some imaging studies (e.g. X-rays etc.), surgical implantation of a portion of…","s":"Completed","tr":["Epidural Stimulation"],"o":[],"st":["Rhode Island"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04302259","su":"https://scitrials.org/trial/NCT04302259"},{"n":"NCT04008160","t":"Intelligent Underwear (IU) in Paraplegics","d":"Pressure injuries are a major problem in patients with no or limited mobility and sensation such as paraplegics. Changes in skin physiology like changes in skin perfusion, oxygenation and humidity may explain and help to detect pressure injury development earlier. Thus, these parameters may be used for continuous monitoring of skin health. So far, there is no measuring technology available which would allow to measure continuously and quantitatively the physiological parameters, which are…","s":"Withdrawn","tr":["Devices","Observational"],"o":["Pressure Sores","Sensory Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04008160"},{"n":"NCT05970367","t":"Intensive Motor Rehabilitation With Technology for Patients With Central Neurological Disease","d":"This project will consist of 1 large clinical trial with 3 core concepts: (1) Clinical benefits of an intensive rehabilitation programme using advanced technology, compared to the control group; (2) A full health economic evaluation combined with model-based estimation of costs and benefits; (3) process evaluation.","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Belgium"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05970367"},{"n":"NCT03076632","t":"Interactions Between Neurostimulation and Physical Exercise","d":"* People with cervical spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) have reduced connections in the nerve circuits between the brain and the hands. Activating spared nerve circuits is one potential way to improve recovery. * The investigators are testing different combinations of physical wrist and hand movements paired with magnetic brain stimulation and electrical spinal cord or nerve stimulation to see the effects on nerve transmission to hand muscles. * This is a…","s":"Withdrawn","tr":["Electrical Stimulation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03076632"},{"n":"NCT02149186","t":"Interactive Motor Imagery in Virtual Reality","d":"This project will build and test the first rehabilitation system employing virtual reality (VR)-based observation, motor imagery and execution to treat lower-limb neuropathic pain and motor dysfunction in participants with an incomplete spinal cord injury or another neurological disorder, eg. stroke: iCTuS-L (Interactive Computer-based Therapy System for legs). Patients using the system will control virtual representations of their legs to engage in entertaining gaming interactions.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Pain Management"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02149186"},{"n":"NCT03469141","t":"Interactive Telehealth for Pressure Ulcer Prevention After SCI","d":"The goal of this module project is to establish the efficacy of a portable sensor and app-based biofeedback technology system for promoting effective pressure relief behaviors and reducing risk of pressure ulcer development among wheelchair users. In collaboration with the participating SCIMS centers, the investigators will conduct a randomized clinical trial of education and goal setting alone compared to education and goal setting combined with the biofeedback system (SENSIMAT®) that is…","s":"Unknown","tr":[],"o":["Pressure Sores"],"st":["Alabama","California","Florida","Pennsylvania"],"co":["United States"],"lc":4,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT03469141","su":"https://scitrials.org/trial/NCT03469141"},{"n":"NCT04266808","t":"Interactive Telehealth for Wheelchair Users","d":"During typical daily activity, people with established spinal cord injury perform significantly fewer pressure-relief maneuvers than the recommended frequency while overestimating their adherence on recall surveys of pressure relief activity. The rate of pressure ulcer recurrence in individuals with a prior ulcer is 44% in those with surgical repair and as high as 75% in those with non-surgical healing indicating that increased attention to pressure relief is critical for these individuals.This…","s":"Unknown","tr":[],"o":["Pressure Sores"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04266808","su":"https://scitrials.org/trial/NCT04266808"},{"n":"NCT06599632","t":"Interdisciplinary Value-based Cognitive Behavioral Treatment for People With Traumatic Spinal Cord Injury","d":"The goal of this clinical trial is to address the critical need for effective interventions by developing and testing an interdisciplinary values-based cognitive behavioral therapy (V-CBT) program for individuals with spinal cord injury. The main question it aims to answer are: * What is the treatment effect of the interdisciplinary values-based cognitive behavioral therapy (V-CBT) program on individuals with spinal cord injury? * What are the temporal relationships between primary and…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06599632"},{"n":"NCT06920524","t":"Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity (MUSIBOT)","d":"Botulinum toxin (BT) injections are a painful treatment frequently used to treat spasticity following central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma). Tolerance of injections varies from patient to patient. For most patients, the pain experienced during the injection is a major source of stress. Numerous clinical trials have demonstrated the role of music therapy in pain management. Music therapy uses a \"U\" shaped technique, allowing the patient to…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Mental Health","Pain Management","Spasticity"],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06920524"},{"n":"NCT07521930","t":"Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)","d":"The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility for more details) to control and receive feedback from assistive devices.","s":"Recruiting","tr":["Brain Machine Interface (BMI)"],"o":[],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07521930","su":"https://scitrials.org/trial/NCT07521930"},{"n":"NCT02230540","t":"Intermittent Catheterization in Spinal Cord Injured Men","d":"The aim of this investigation is to study how the position of different catheters affect drainage of the bladder.","s":"Terminated","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02230540"},{"n":"NCT06807528","t":"Intermittent Fasting for Inflammation and Depression in Spinal Cord Injury","d":"Depression and chronic inflammation are common problems for people with spinal cord injury (SCI). Inflammation has been shown to influence depression which may make it an important treatment target. Previous studies have shown that changes in diet and exercise can affect this pathway and improve symptoms of depression in SCI patients. However, following these interventions long-term can be difficult. Intermittent fasting is a way of eating that involves fasting for a certain period of time and…","s":"Not yet recruiting","tr":["Nutrition"],"o":["Mental Health"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06807528","su":"https://scitrials.org/trial/NCT06807528"},{"n":"NCT05513911","t":"Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury","d":"In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Arm Movement","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05513911"},{"n":"NCT01272349","t":"Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI","d":"The goal of the study is to determine whether repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) will improve limb function after spinal cord injury. This idea stems from animal studies on respiration, in which investigators have shown that mild intermittent hypoxia improves breathing in spinally injured rats. These studies have shown that intermittent hypoxia induces spinal plasticity, strengthening neural connections and motor neuron function within the…","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Breathing Function","Motor Function","Plasticity","Walking Function"],"st":["Georgia","Illinois"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01272349"},{"n":"NCT03071393","t":"Intermittent Hypoxia to Enhance Motor Function After Spinal Cord Injury","d":"This study will examine if acute intermittent hypoxia (brief episodes of breathing lower oxygen), which has been shown to enhance plasticity and motor output, can enhance functional outcomes and muscle activation in individuals with spinal cord injury. Our aim is to assess breathing, sitting, standing and walking functional ability before and after acute intermittent hypoxia, compared to a sham treatment. This information may be useful in advancing rehabilitation for people with spinal cord…","s":"Completed","tr":["Devices","Intermittent Hypoxia","Rehabilitation"],"o":["Breathing Function","Motor Function","Plasticity","Walking Function"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03071393"},{"n":"NCT00476866","t":"Intermittent Positive-Pressure Breathing Effects in Patients With High Spinal Cord Injury","d":"Background: To determine whether intermittent positive-pressure breathing (IPPB) improved lung compliance, work of breathing, and respiratory function in patients with recent high spinal cord injury (SCI). Methods: Two months of IPPB and two months of conventional treatment have to evaluated prospectively in random order in 14 patients with SCI. Noninvasive lung function tests and arterial blood gas measurements have to be obtained repeatedly. Repeated measurements of dynamic compliance and…","s":"Terminated","tr":["Devices"],"o":["Breathing Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00476866"},{"n":"NCT06248476","t":"Intermittent Theta Burst Stimulation and Repetitive Transcranial Magnetic Stimulation Combined With Robotic Rehabilitation on Ambulation in Spinal Cord Injury Patients","d":"Comparison of different types of transcranial magnetic stimulation techniques which are intermittent theta burst stimulation (iTBS) and high frequency repetitive transcranial magnetic stimulation (rTMS) in patients with spinal cord injury","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Motor Function","Quality of Life","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06248476"},{"n":"NCT02168465","t":"Internet Self-Management for People With Intermittent Urinary Catheters","d":"1. Design and develop web-based self-management intervention to improve catheter-related outcomes and quality of life in people with spinal cord injury (SCI). 2. Conduct a pilot study to assess the feasibility (i.e., acceptability and usability of the website application) and preliminary effectiveness of this new self-management intervention. 3. Develop and test the reliability of new/modified measures (intermittent catheter self-efficacy and self-management).","s":"Completed","tr":["Devices"],"o":["Bladder Function","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02168465"},{"n":"NCT03963843","t":"Internet-delivered Cognitive Behavioural Therapy for Persons With Spinal Cord Injury","d":"In Canada the prevalence of spinal cord injury (SCI) is approximately 85,556, with incidence rates of traumatic and non-traumatic SCI at 1,785 and 2,286 cases per year, respectively. Common secondary health conditions experienced by individuals with SCI include psychological distress and pain. Appropriate management of these secondary conditions, through a multidisciplinary approach, is imperative as they have been shown to contribute to slower recovery, increased negative outcomes, and greater…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03963843"},{"n":"NCT05615402","t":"Intervention on Bone Health in Wheelchair Users","d":"The low mechanical loading of bones among wheelchair users leads to an increased risk of bone fractures and associated complications due to low bone mineral density (BMD). Adding mechanical loading through physical activity in combination with optimizing nutrition may counteract these negative consequences in wheelchair users and thereby provide positive impact for bone health, as well as for physical and mental health. In this project, a multidisciplinary team will tailor a bone-specific…","s":"Completed","tr":["Nutrition"],"o":["Bone Strength","Mental Health","Motor Function"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05615402"},{"n":"NCT01903226","t":"Intervention Study to Assess the Effects of Moderate and High Intensity Aerobic Training on Physical Capacity and Activity Level in Persons With Incomplete Spinal Cord Injury","d":"The aims of this study are to assess the effects of medium versus high intensity 12-week adjusted training programs on physical capacity in persons with incomplete SCI, early after discharge from primary rehabilitation, and to investigate if the training program induces a more active lifestyle in terms of increased daily energy expenditure.","s":"Completed","tr":["Rehabilitation"],"o":[],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01903226"},{"n":"NCT05508802","t":"Interventional Cooperative Agreement Program - Vocational Intervention Demonstration","d":"For many people with spinal cord injury or brain injury, seeking employment after injury is an important goal. There are services available to help people with disabilities. However, the best ways to coordinate and deliver these services are not yet known. This project will compare two ways of coordinating and delivering services that are designed to help people with spinal cord injury or brain injury obtain employment.","s":"Not yet recruiting","tr":[],"o":["Mental Health"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05508802","su":"https://scitrials.org/trial/NCT05508802"},{"n":"NCT01637766","t":"Intra-arterial Chemotherapy for Spinal Metastases","d":"Metastatic malignant tumors comprise the vast majority of spinal tumors in adults. The most devastating complication of spinal metastatic disease (SMD) is invasion of the spinal canal and compression of the spinal cord or the nerve roots of the cauda equina, resulting in a clinical entity known as cord compression that manifests with progressive loss of motor function and sensation in the legs, as well as bladder and bowel incontinence. The treatment of spinal metastases is mostly palliative…","s":"Completed","tr":["Drugs","Surgical Procedure"],"o":["Bladder Function","Bowel Function","Motor Function","Sensory Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01637766"},{"n":"NCT07488702","t":"Intradurale Spinal Tumors: Management and Treatment","d":"Intradurale spinal tumors are rare neoplastic lesions that involve the spinal cord and surrounding structures and may cause neurological symptoms such as pain, motor deficits, sensory disturbances, and sphincter dysfunction. Surgical resection is often the primary treatment when feasible and may improve neurological outcomes and relieve spinal cord compression. This retrospective observational study aims to analyze the epidemiological and clinical characteristics of patients who underwent…","s":"Active, not recruiting","tr":["Observational","Surgical Procedure"],"o":["Pain Management"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07488702"},{"n":"NCT04550117","t":"Intraspinal Pressure Monitoring for Acute Traumatic Spinal Cord Injury: A Validation Study","d":"Intraspinal pressure monitoring has been advanced as a potential technique for evaluating spinal cord perfusion after traumatic spinal cord injury. In this study, the investigators aim to validate the technique for insertion of a fiberoptic pressure monitoring device in the subarachnoid space at the site of injury for measurement of intraspinal pressure and spinal cord perfusion pressure. The primary objective of this study is to validate the methodology of invasive intraspinal pressure…","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04550117","su":"https://scitrials.org/trial/NCT04550117"},{"n":"NCT02903823","t":"Intrathecal (IT) Baclofen Drug Distribution","d":"The goal of this pilot study to determine whether there is a significant therapeutic advantage to place the ITB catheter within the cervical, thoracic or lumbar region of the spine. It is also a goal of this pilot study to determine whether the origin of spasticity influences the effect of Lioresal Intrathecal (baclofen injection) on ITB catheters located in the cervical, thoracic or lumbar regions of the spine. The investigators propose to study the impact of catheter location on the reduction…","s":"Completed","tr":["Devices","Drugs"],"o":["Spasticity"],"st":["Tennessee"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02903823"},{"n":"NCT03003364","t":"Intrathecal Administration of Expanded Wharton's Jelly Mesenchymal Stem Cells in Chronic Traumatic Spinal Cord Injury","d":"This is a phase I/IIa, randomized, double-blind, two-arms, two-dose administration, placebo controlled, two-way crossover clinical trial in which 10 patients from 18 to 65 years of age affected with chronic traumatic spinal cord will enter the study with the objective to assess the safety and to obtain efficacy data in intrathecal administration of expanded Wharton's jelly mesenchymal stem cells.","s":"Completed","tr":["Drugs","Stem Cells"],"o":["Bladder Function","Mental Health","Pain Management","Quality of Life","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03003364"},{"n":"NCT02705950","t":"Intrathecal Baclofen (ITB) Bolus on Neuropathic Pain (NP). Preliminary Study.","d":"Hypothesis: ITB bolus can have antinociceptive effect on neuropathic pain in spinal cord injury patients, which could depend on the subtype of pain, or on the lesion level, cervical or thoracic spinal cord injury. Objective: To study the effect of intrathecal baclofen bolus on neuropathic pain in patients with spinal cord injury at cervico-dorsal level. Primary Endpoint: Effect of intrathecal baclofen bolus in neuropathic pain (measured using the Neuropathic Pain Inventory Scale, the Brief Pain…","s":"Completed","tr":["Drugs"],"o":["Pain Management","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02705950"},{"n":"NCT00215527","t":"Intrathecal Enzyme Replacement Therapy for Spinal Cord Compression in Mucopolysaccharidosis (MPS) I","d":"The investigators are studying the use of enzyme replacement therapy into the spinal fluid for treatment of spinal cord compression in the Hurler-Scheie and Scheie forms of mucopolysaccharidosis I (MPS I). Funding source -- FDA OOPD","s":"Terminated","tr":["Drugs"],"o":[],"st":["California"],"co":["Finland","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00215527"},{"n":"NCT01624779","t":"Intrathecal Transplantation Of Autologous Adipose Tissue Derived MSC in the Patients With Spinal Cord Injury","d":"The effect of intrathecal transplantation of autologous adipose tissue derived mesenchymal stem cells in the patients with spinal cord injury, Phase I Clinical study.","s":"Completed","tr":["Drugs","Stem Cells"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01624779"},{"n":"NCT03521323","t":"Intrathecal Transplantation of UC-MSC in Patients With Early Stage of Chronic Spinal Cord Injury","d":"This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of spinal cord injury. Here, the history of spinal cord injury is divided into three periods, Sub-acute SCI, Early stage of chronic SCI, and Late stage of chronic SCI, which is 2W-2M, 2M-12M, and more than 12M after injury, respectively. The purpose is to investigate whether the patients with spinal cord injury…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03521323","su":"https://scitrials.org/trial/NCT03521323"},{"n":"NCT03505034","t":"Intrathecal Transplantation of UC-MSC in Patients With Late Stage of Chronic Spinal Cord Injury","d":"This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of spinal cord injury. Here, the history of spinal cord injury is divided into three periods, Sub-acute SCI, Early stage of chronic SCI, and Late stage of chronic SCI, which is 2W-2M, 2M-12M, and more than 12M after injury, respectively. The purpose is to investigate whether the patients with spinal cord injury…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03505034","su":"https://scitrials.org/trial/NCT03505034"},{"n":"NCT03521336","t":"Intrathecal Transplantation of UC-MSC in Patients With Sub-Acute Spinal Cord Injury","d":"This study aim to evaluate the safety and efficacy of intrathecal transplantation of allogeneic umbilical cord derived mesenchymal stem cells (UC-MSC) for treatment of different phrases of spinal cord injury. Here, the history of spinal cord injury is divided into three periods, Sub-acute SCI, Early stage of chronic SCI, and Late stage of chronic SCI, which is 2W-2M, 2M-12M, and more than 12M after injury, respectively. The purpose is to investigate whether the patients with spinal cord injury…","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03521336","su":"https://scitrials.org/trial/NCT03521336"},{"n":"NCT03945110","t":"Intravesical Glycosaminoglycan Instillation and Urinary Tract Infection in Acute Spinal Cord Injury","d":"The purpose of this study is to assess the safety and feasibility of administering glycosaminoglycan (GAG) therapy, iAluRil®, intravesically in individuals with acute spinal cord injury (SCI), commencing within the first ten days of injury, to prevent early urinary tract infections.","s":"Completed","tr":["Devices","Safety"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Australia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03945110"},{"n":"NCT01091727","t":"Intravesical Injection of Botulinum Toxin A Versus Saline for Neurogenic Detrusor Overactivity","d":"This is a prospective, multicentre (7 sites), randomized, double-blind, study comparing intravesical injection of BOTOX to placebo in 56 subjects with NDO secondary to spinal cord injury or multiple sclerosis. Study subjects will be randomized to one of the following two treatment groups: Group 1 n=28 BOTOX - 300U Group 2 n=28 Placebo BOTOX (saline) All study subjects will receive one injection cycle (BOTOX 300U or Placebo) at Visit 2 (Treatment, Day 0) as per Supplement III. The study duration…","s":"Completed","tr":["Drugs"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01091727"},{"n":"NCT07308808","t":"Intravesical Lactobacillus Crispatus: Clinical Safety and Microbiome Evaluation","d":"The goal of this clinical trial is to determine whether Lactobacillus crispatus strains isolated from the lower urinary tracts of adult women can be used as an antibiotic-sparing treatment for urinary symptoms and urinary tract infection (UTI) among adults with neurogenic lower urinary tract dysfunction (NLUTD). The main question\\[s\\] it aims to answer are: 1. To identify soluble bactericidal compounds produced by urinary isolates of L. crispatus that kill uropathogenic E. coli (UPEC). 2. To…","s":"Recruiting","tr":["Drugs"],"o":["Bladder Function"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07308808","su":"https://scitrials.org/trial/NCT07308808"},{"n":"NCT04373512","t":"Intravesical Lactobacillus to Reduce Urinary Symptoms After Spinal Cord Injury","d":"The objectives of the proposed research among this population are: 1) to define clinically meaningful change (i.e. differentiating states of health and illness) with respect to urinary symptoms, urine inflammation, cultivable bacteria, and the urine ecosystem; and 2) to determine the optimal intravesical Lactobacillus RhamnosusGG (LGG®) dose to be used to reduce urinary symptoms in a future clinical trial.","s":"Completed","tr":["Devices","Drugs"],"o":["Bladder Function"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04373512"},{"n":"NCT05230511","t":"Intravesical LGG VS Saline Bladder Wash RCT","d":"This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).","s":"Recruiting","tr":[],"o":["Bladder Function"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05230511","su":"https://scitrials.org/trial/NCT05230511"},{"n":"NCT07467187","t":"Invasive Home Ventilation in Denmark","d":"The aim of this study is to describe national trends over the past 10 years in patients receiving invasive home mechanical ventilation (HMV) in Denmark. This includes indications for invasive HMV, diagnostic groups, and one-year mortality.","s":"Recruiting","tr":["Observational"],"o":["Breathing Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07467187"},{"n":"NCT00320281","t":"Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.","d":"As clinicians, it is often a struggle to find effective pain control for a certain subgroup of patients with tetraplegia. These patients often have severe upper back, neck, and shoulder pain, limiting rehabilitation productivity and potential, and always limiting quality of life. This pain appears to be primarily musculoskeletal. Muscles in the upper back and neck become shortened, rock hard, and extremely tender with even the slightest touch or stretch. Refractory to multiple classes of…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Pain Management","Quality of Life","Spasticity"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00320281"},{"n":"NCT02150629","t":"Investigating Kinematic and Electromyographic Changes After SCI and Their Relation to Clinical and Functional Outcome","d":"The study aims at discerning specific gait patterns and elucidating locomotor control of spinal cord injured patients in order to find sensitive kinematic and electromyographic outcome measures that are able to reveal information on underlying mechanisms of normal and aberrant gait control and its recovery over time. These measures may also be used to compare the outcome across different neurological disorders.","s":"Completed","tr":["Observational"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02150629"},{"n":"NCT03661294","t":"Investigating the Energy Expenditure of Acute Spinal Cord Injured Patients","d":"It is recognised that weight gain is a common problem in patients with a spinal cord injury and can lead to an increased incidence of metabolic syndrome. Weight gain is thought to be attributed to excess calorie intake, reduction in energy requirements and / or a reduction in exercise. However, further understanding of this energy imbalance needs to be addressed. This feasibility study will initially determine if it is feasible to measure the 'actual' energy requirements of 15 paraplegic and 15…","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Blood Pressure"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03661294"},{"n":"NCT07037628","t":"Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury","d":"This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries: 1. Spinal cord stimulation (SCS) combined with one-on-one physical therapy 2. One-on-one physical therapy alone","s":"Not yet recruiting","tr":["Electrical Stimulation","Rehabilitation"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07037628","su":"https://scitrials.org/trial/NCT07037628"},{"n":"NCT06740279","t":"Investigating the Upper Limb During the First 6 Months After Sustaining a Cervical Spinal Cord Injury,","d":"The goal of this observational study is to investigate and describe the injury patterns, secondary complications, and biomechanical properties of the upper limb during the initial 6 months post-SCI. The overarching objective is to investigate and describe the trajectory of upper limb functioning, secondary complications, and biomechanical properties of the upper limb during the initial 6 months post-SCI and explore factors influencing functional use of the hands at 6 months after injury.","s":"Not yet recruiting","tr":[],"o":["Arm Movement"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06740279","su":"https://scitrials.org/trial/NCT06740279"},{"n":"NCT03744286","t":"Investigation Into an Innovative, Clinical Slip Inducing Device in the Chronic Incomplete Spinal Cord Population","d":"The objective of this project is to fully test a newly developed affordable cost variable slip inducer in the ambulatory, incomplete spinal cord population. It is a self-contained device using a moving serial plank mechanism with wheels on the underside of each plank that allow for structured slips while a person walks over the planks with a harness for safety.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03744286","su":"https://scitrials.org/trial/NCT03744286"},{"n":"NCT03621254","t":"Investigation Into Optimal FES Training Characteristics After Spinal Cord Injury","d":"The aim of this study is to investigate two different modalities of functional electrical stimulation (FES) leg exercise in patients with spinal cord injury (SCI). The primary outcomes being compared are 1. FES-induced leg aerobic fitness, and 2. FES-induced leg strength. There will be two FES-leg training groups, and sub-acute patients with SCI will be randomised between the groups - high-short \\[HI-SHORT\\] and low-long \\[LO-LONG\\]. Both groups (n=10 per group) will exercise on the Hasomed…","s":"Recruiting","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03621254","su":"https://scitrials.org/trial/NCT03621254"},{"n":"NCT03854214","t":"Investigation of Brain Functional MRI as an Early Biomarker of Recovery in Individuals With Spinal Cord Injury","d":"Early detection of response to therapeutic intervention is vital, as it will enable early termination of intervention in non-responding patients, prevent unnecessary financial burden, and allow for early changes to the intervention program. Previous functional MRI (fMRI) studies have shown that changes in brain functional network in spinal cord injury (SCI) patients can occur after as little as one week of intervention. Resting state fMRI (rsfMRI) is a type of fMRI that does not require…","s":"Completed","tr":["Devices"],"o":[],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03854214"},{"n":"NCT05163899","t":"Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients","d":"The investigators hypothesize that surgical release of the filum terminale (strand of fibrous tissue at the end of the spinal cord) is a more efficacious treatment option for symptomatic relief than medical management in subjects with Occult Tethered Cord Syndrome (OTCS) and that the risks do not outweigh the benefit profile.","s":"Recruiting","tr":["Surgical Procedure"],"o":["Bladder Function","Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05163899"},{"n":"NCT06872931","t":"Investigation of the Effects of C-Mill (Hocoma AG, Switzerland) Treadmill Training on Trunk Balance in Patients with Spinal Cord Injury","d":"This study examines how C-Mill treadmill training affects balance and stability in people with spinal cord injury (SCI). Many individuals with SCI experience difficulty with sitting and walking balance, which affects their daily activities and independence. This research aims to explore whether C-Mill, a treadmill that combines virtual reality and sensor-based walking support, can improve trunk stability and mobility. Who Can Join the Study? People who: Are between 18-65 years old Have a spinal…","s":"Active, not recruiting","tr":["Devices","Rehabilitation"],"o":["Quality of Life","Trunk Control"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06872931","su":"https://scitrials.org/trial/NCT06872931"},{"n":"NCT03161067","t":"Investigation on the Bidirectional Cortical Neuroprosthetic System","d":"The Bidirectional Cortical Neuroprosthetic System (BiCNS) consists of NeuroPort Microelectrode Array Systems and NeuroPort Electrodes (Sputtered Iridium Oxide Film), Patient Pedestals, the NeuroPort BioPotential Signal Processing System, and the CereStim C96 Programmable Stimulator. The goals of this early feasibility study consist of safety and efficacy evaluations of this device.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03161067","su":"https://scitrials.org/trial/NCT03161067"},{"n":"NCT02566850","t":"Investigational Study of the Ekso for High-Dosage Use by Individuals With SCI in a Non-Clinical Environment","d":"The purpose of the study is to study the safety and health effects of using the Ekso Bionics powered exoskeleton device in a home setting over an extended period, ranging from 12-42 months.","s":"Terminated","tr":["Devices","Exoskeleton"],"o":["Bladder Function","Bowel Function","Leg Movement","Motor Function","Quality of Life","Spasticity"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02566850"},{"n":"NCT02034331","t":"IR and Microvascular Blood Flow in SCI","d":"Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel function below the level of injury. Insulin, which facilitates the transport of glucose into muscle cells, is also capable of regulating skin blood flow, with insulin resistance reducing perfusion. Although beyond the scope of this proposal, the possibility exists that…","s":"Completed","tr":["Drugs"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02034331"},{"n":"NCT00881803","t":"Iron & Vitamin C Study","d":"Iron overload is a life-threatening condition that can lead to liver disease, cardiac disease, diabetes and arthritis. Simultaneous supplementation with both iron and AA may place individuals with SCI at risk for iron overload as well as oxidative damage by iron-generated free radicals. Both conditions of high and low iron stores may present with common signs and symptoms. Accurate diagnosis of iron disorder should consider CRP, hematocrit, hemoglobin, serum iron, TIBC, percent saturation of…","s":"Completed","tr":["Nutrition","Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00881803"},{"n":"NCT02138149","t":"Is the Nerve Growth Factor (NGF) a Useful Biomarker in Neurogenic Bladder Dysfunction After Spinal Cord Injury?","d":"Spinal cord injury (SCI) almost always affects bladder function as well. As a result of this bladder dysfunction, individuals with SCI have to undergo regular invasive examination of their bladder function (urodynamic examination). The nerve growth factor (NGF) is released from smooth muscle cells of the bladder, and there are reports, that the concentration of NGF is elevated in the urine of patients with bladder dysfunction. The NGF concentration can also be measured in the blood. The…","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02138149"},{"n":"NCT05954715","t":"Ischaemic Preconditioning and Upper Body Exercise Performance in Persons With Spinal Cord Injury","d":"Regular physical activity improves physical fitness, fatigue, quality of life, gait and reduces progression of the disability in persons with SCI. However, persons with SCI are less physically active than the general population. Approximately 50% of people with SCI experience fatigue which impacts their daily activities. Ischaemic preconditioning (IPC) is exposure of the body to brief periods of circulatory occlusion and reperfusion to protect organs against ischaemic injury. Recent studies…","s":"Unknown","tr":["Rehabilitation"],"o":["Arm Movement"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05954715","su":"https://scitrials.org/trial/NCT05954715"},{"n":"NCT03773692","t":"Just-in-time Adaptive Feedback Systems to Assist Individuals With Spinal Cord Injury","d":"The objective of this study is to develop algorithms that incorporate each individual's automatically detected physical activity (PA) level and a clinician's PA level recommendation to provide a smartphone application that helps a person set safe and highly personalized PA goals. By adapting the goals in real-time based on the person's actual behavior, the system aims to keep the individual feeling positive and motivated towards a change in the PA behavior.","s":"Completed","tr":[],"o":["Pain Management"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03773692"},{"n":"NCT04855916","t":"KAFO Orthoses Versus the ABLE Exoskeleton","d":"This randomized crossover study will compare walking with KAFO type orthoses (current standard of care) versus the ABLE Exoskeleton device, during walking in patients with spinal cord injury in a hospital setting. The ABLE Exoskeleton is a robotic exoskeleton that actively assists individuals with mobility problems to stand up, walk and sit down. The main objective of the study is to compare the energy efficiency during gait with both devices. Secondary objectives are: compare gait kinematics…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Mental Health","Quality of Life","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04855916"},{"n":"NCT03531164","t":"Kayak Ergometer Training in Individuals With Spinal Cord Injury","d":"One of the main objectives in spinal cord injury rehabilitation programs is the improvement of trunk control in order to achieve independence, to prevent complications and, in specific cases to walk. Research question: What is the effect of kayak ergometer training in trunk control, cardiovascular condition and independence in individuals with a spinal cord injury? Purpose: To determine the effect of kayak ergometer training in trunk control, cardiovascular condition and independence in…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Mexico"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03531164","su":"https://scitrials.org/trial/NCT03531164"},{"n":"NCT03509571","t":"Ketogenic Diet to Improve Neuro-recovery","d":"The purpose of this project is to determine if 5 weeks of ketogenic (KD, high-fat) diet vs. standard diet (SD) significantly improves motor and sensory function, glycemic function, and functional independence in patients with spinal cord injury.","s":"Completed","tr":["Nutrition"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03509571","su":"https://scitrials.org/trial/NCT03509571"},{"n":"NCT07705984","t":"Kinesio Taping for Neurogenic Bowel Dysfunction in Spinal Cord Injury","d":"Neurogenic bowel dysfunction is a common complication of spinal cord injury and may cause constipation, difficulty with defecation, prolonged bowel care, incomplete evacuation, fecal incontinence, and reduced quality of life. This randomized controlled trial aims to evaluate the effectiveness of Kinesio Taping added to a routine bowel management program in adults with spinal cord injury and upper motor neuron-type neurogenic bowel dysfunction. Thirty participants will be randomly assigned to…","s":"Not yet recruiting","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07705984"},{"n":"NCT07549217","t":"Kinesiophobia, Fear of Falling, Functional Independence, and Psychological Status in Spinal Cord Injury","d":"Individuals aged 18-65 years who have been clinically diagnosed with spinal cord injury and have developed paraplegia will be included in the study. Demographic and clinical data of the participants, including age, sex, height, weight, etiology of injury, level of injury, duration of injury, and comorbidities, will be recorded. In addition, disease-specific characteristics such as ambulation status, wheelchair use, presence of incontinence, and presence and severity of pain will be assessed…","s":"Not yet recruiting","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07549217","su":"https://scitrials.org/trial/NCT07549217"},{"n":"NCT02533882","t":"Lakeshore Examination of Activity and Disability Exercise Response Study","d":"This study will examine the effectiveness of two types of group exercise classes on the health and functional status in inactive adults age 18-65 with neurological conditions including Multiple Sclerosis, stroke, and spinal cord injury (SCI). Participants will be randomly assigned to one of three groups; Movement to Music, Adapted Yoga, or a waitlist group who will complete a home-based exercise intervention of either Movement to Music or Adapted Yoga.","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure","Hand Movement","Mental Health","Motor Function","Pain Management","Trunk Control"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02533882"},{"n":"NCT05360524","t":"Laminectomy Alone Versus Laminectomy and Fusion for Traumatic Cervical Spinal Cord Injury Without Instability","d":"The aim of study is to compare clinical and radiological outcomes of laminectomy alone to laminectomy and fusion in the treatment of traumatic cervical spinal cord injury without instability.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05360524","su":"https://scitrials.org/trial/NCT05360524"},{"n":"NCT05023772","t":"Laser Interstitial Thermal Ablation and Stereotactic Radiosurgery for Patients With Spine Metastases","d":"The purpose of this research is to combine two complementary modes of treatment, spinal interstitial laser ablation and stereotactic spine radiosurgery (SSRS) for the treatment for spinal tumors near the spinal cord with an objective to improve tumor control, improve pain control, preserve function, and improve quality of life. We will also assess how effective these combined modes of treatment are in patients with spinal metastasis with an epidural component.","s":"Recruiting","tr":[],"o":["Pain Management","Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05023772"},{"n":"NCT02750982","t":"Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases.","d":"This is a prospective investigation of the effects of Laughter therapy (LT) on perceived stress, self-efficacy, mood and other wellness measures in people with the following neurological conditions: Alzheimer's disease, amyotrophic lateral sclerosis, brain injury, Huntington's Disease, multiple sclerosis, Parkinson's Disease, post-stroke, spinal cord injury.","s":"Completed","tr":[],"o":["Mental Health"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02750982"},{"n":"NCT03458169","t":"LEAP a New Overground Body Weight Support Robot: Usability Trial","d":"People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and independence. Different body-weight support systems have been developed to facilitate the rehabilitation process by compensating for the user's residual abilities. However, studies on weight-supported gait training on a treadmill have failed to show superiority over…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03458169"},{"n":"NCT05926596","t":"Leg Stretching Using an Exoskeleton on Demand for People With Spasticity","d":"The purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders. The study investigates the effects of wearing the device during a set of experiments including leg stretching, treadmill walking and overground walking in muscle activity, joint motion, and gait performance. The goal is to develop an effective lower-limb strategy to restore lost leg function (e.g., range of…","s":"Recruiting","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05926596","su":"https://scitrials.org/trial/NCT05926596"},{"n":"NCT02860637","t":"Level and Degree of Spinal Cord Injury and Its Impact on Male Sexual Function","d":"In addition to the motor and sensory functions, sexual function changes after spinal cord injury and is considered one of the most common problems, ranging from a decrease in sexual desire to disturbances of erection, orgasm and ejaculation. Objective: To assess the impact of the complexity of traumatic spinal cord injury in male sexual function.","s":"Completed","tr":["Observational"],"o":["Sexual Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02860637"},{"n":"NCT00252954","t":"Levetiracetam in Chronic Neuropathic Pain Following Spinal Cord Injury","d":"Purpose: To evaluate the efficacy and safety of levetiracetam on chronic neuropathic pain after spinal cord injury, and to examine its effect on spasms and evoked pain.","s":"Completed","tr":["Drugs"],"o":["Pain Management","Spasticity"],"st":[],"co":["Denmark"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00252954"},{"n":"NCT05284201","t":"LIFT Home Study of Non-Invasive ARC Therapy for Spinal Cord Injury","d":"The LIFT Home Study is an observational, single-arm study designed to assess the safety of non-invasive electrical spinal stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in people with chronic tetraplegia.","s":"Completed","tr":["Electrical Stimulation"],"o":["Arm Movement"],"st":["Colorado","Georgia","Massachusetts","Minnesota","Washington"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05284201"},{"n":"NCT01963026","t":"Linking Brain to Behaviour Research in SCI","d":"Introduction In recent years, client-centred and task-oriented training have emerged as important methods in rehabilitation including the rehabilitation of persons with spinal cord injury (SCI). The task-oriented intervention focuses on resolving, reducing and preventing impairment, developing effective task-specific strategies and adapting functional goal-oriented strategies to changing environmental conditions. Currently, task-specific training is mainly achieved by constant practice (i.e…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01963026"},{"n":"NCT01471613","t":"Lithium, Cord Blood Cells and the Combination in the Treatment of Acute & Sub-acute Spinal Cord Injury","d":"The trial is to investigate the safety and efficacy of oral lithium, intraspinal umbilical cord blood mononuclear cell transplant, and the combination in the treatment of acute and subacute spinal cord injury","s":"Completed","tr":["Drugs","Stem Cells"],"o":["Pain Management","Spasticity","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01471613"},{"n":"NCT06227000","t":"Living Longer and Stronger With Spinal Cord Injury (SCI)","d":"The purpose of this study is to develop a health promotion group intervention to meet the unique health promotion needs of people aging with SCI, to test the efficacy of the adapted intervention program, Living Longer and Stronger with SCI, in a randomized controlled trial and to assess the mechanisms through which the intervention may enhance physical, psychological, and social health.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06227000","su":"https://scitrials.org/trial/NCT06227000"},{"n":"NCT03709732","t":"Living With Spinal Cord Injury.","d":"A Spinal Cord Injury (SCI) often drastically disrupts the lives of affected patients and their relatives and caregivers. This observational study will provide new knowledge on how patients and their family caregivers cope in the first years after injury in terms of work inclusion, participation, care giver burden and quality of life. This project will utilize Norwegian spinal cord injury quality register data and link clinical individual data from the quality register to national administrative…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03709732"},{"n":"NCT04879862","t":"Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury","d":"The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The overall objective of this study is to demonstrate that epidural stimulation may be a method for improving stepping, standing and bladder function in individuals with spinal cord injury. With the use of epidural stimulation, the investigators propose to…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Bladder Function","Walking Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04879862","su":"https://scitrials.org/trial/NCT04879862"},{"n":"NCT04052009","t":"Locomotor Training in Individuals With Incomplete Spinal Cord Injury. A Pilot Study","d":"Background: In Switzerland, about 6000 individuals live with the consequences of a spinal cord injury (Brinkhof et al, 2016). One of the major goals after an incomplete spinal cord injury (iSCI) is to regain walking function. To this end, different approaches are used in rehabilitation such as treadmill-based, robotic-assisted (exoskeleton or end-effector) and conventional gait training. According to current literature, the superiority of one of these approaches remains unclear (Mehrholz…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04052009","su":"https://scitrials.org/trial/NCT04052009"},{"n":"NCT02600013","t":"Locomotor Training With Exoskeleton EKSO-GT in Patients With Incomplete Motor Spinal Cord Injury in a Hospital Setting","d":"The aim of this observational, non-controlled, non-profit study is to describe the responses to rehabilitative training with the robotic exoskeleton EKSO-GT in patients with incomplete motor Spinal Cord Injury (AIS C or D). Such rehabilitative tool is employed during inpatient intensive rehabilitation in a 3rd level Italian hospital. Safety and tolerability of the device are also assessed and described.","s":"Completed","tr":["Devices","Exoskeleton","Observational","Rehabilitation","Safety"],"o":["Blood Pressure","Leg Movement","Mental Health","Motor Function","Pain Management","Pressure Sores","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02600013"},{"n":"NCT04460872","t":"Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury","d":"This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and overground walking) in men with testosterone deficiency and walking dysfunction after incomplete or complete spinal cord injury. The investigators hypothesize that LT+TRT treatment will improve muscle size and bone mineral density in men with low T and ambulatory dysfunction…","s":"Recruiting","tr":["Rehabilitation"],"o":["Bone Strength","Walking Function"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT04460872","su":"https://scitrials.org/trial/NCT04460872"},{"n":"NCT01087918","t":"Lokomat Versus Strength Training in Chronic Incomplete Spinal Cord Injury","d":"The purpose of this pilot study is to investigate whether gait specific robotic supported bodyweight supported treadmill training and lower extremity strength training have similar beneficial effects on walking function and other outcomes.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Motor Function","Pain Management","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01087918"},{"n":"NCT07137780","t":"Lokomat® vs RoboGait® Under Different Guidance Force Settings in Motor-Incomplete SCI","d":"This study compares two robotic-assisted gait training systems, Lokomat® and RoboGait®, used under different guidance force (GF) settings, in people with motor-incomplete spinal cord injury (iSCI). Nineteen adults, aged 18 years or older, with injury at T3 level or below and classified as AIS C or D within two years of injury, participated. They were assigned to one of three groups based on the average GF used during training: Lok90- (GF \\< 90% with Lokomat®), Lok90+ (GF ≥ 90% with Lokomat®)…","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07137780"},{"n":"NCT03139344","t":"Long Duration Activity and Metabolic Control After Spinal Cord Injury","d":"Skeletal muscle is the largest endocrine organ in the body, playing an indispensable role in glucose homeostasis. Spinal cord injury (SCI) prevents skeletal muscle from carrying out this important function. Dysregulation of glucose metabolism precipitates high rates of metabolic syndrome, diabetes, and other secondary health conditions (SHCs) of SCI. These SHCs exert a negative influence on health-related quality of life (HRQOL). New discoveries support that a low level of activity throughout…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Iowa"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03139344"},{"n":"NCT03063333","t":"Long-term Effect of Hypnosis in Spinal Cord Injury Patients","d":"Coping-oriented hypnotic suggestions aimed at reducing pain catastrophizing was shown to reduce pain in people with chronic tension-type headache and experimental pain in healthy volunteers during hypnosis (Kjøgx et al., 2016). However, the duration of the effect on pain post-hypnosis is unknown. The aim is to investigate the durational effect of a single session of coping-oriented hypnotic suggestions on chronic pain in patients with spinal cord injury. If effective for a longer period…","s":"Terminated","tr":[],"o":["Mental Health","Pain Management"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03063333"},{"n":"NCT05226676","t":"Long-term Effects of Repetitive TMS in Chronic Neuropathic Pain in People With SCI","d":"Around 80% of people with spinal cord injury (SCI) develop chronic neuropathic pain (CNP). This is a debilitating condition with major negative impacts on people's quality of life. Many treatment options have been offered (invasive stimulation, drugs) but provide limited effects and many secondary effects. There is a critical need to develop a new generation of therapies. Transcranial magnetic stimulation (TMS) is a non-invasive and painless brain stimulation technique that allows researchers…","s":"Withdrawn","tr":["Brain Stimulation","Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05226676"},{"n":"NCT03910101","t":"Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity Treatment","d":"Spasticity - a variety of motor over-activity and part of the upper motor neuron syndrome - is a common cause of impaired motor function after brain injuries of different etiologies. In addition, it may cause pain and impaired hygiene, contractures, deformities etc. Spasticity has been reported in 30 to 90% of patients with stroke, traumatic brain injury (TBI), incomplete spinal cord injury (SCI) and cerebral palsy (CP). Spasticity therapy has emerged as an important approach to alleviate…","s":"Completed","tr":["Rehabilitation","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Motor Function","Pain Management","Spasticity"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03910101"},{"n":"NCT07042815","t":"Long-term Follow-up for Epidural Stimulation in SCI","d":"The goal of this study is to understand long-term effects of spinal cord stimulation in individuals who have a spinal cord injury. The main aims are to: 1. provide support for those with epidural stimulators who choose to continue stimulating because they deemed them to improve their quality of life 2. provide additional sites for follow-up so that the financial burden can be minimized for the research participants to travel 3. collect long-term safety data; and 4. when feasible collect data to…","s":"Enrolling by invitation","tr":["Epidural Stimulation"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07042815","su":"https://scitrials.org/trial/NCT07042815"},{"n":"NCT01725880","t":"Long-Term Follow-Up of Transplanted Human Central Nervous System Stem Cells (HuCNS-SC) in Spinal Cord Trauma Subjects","d":"The purpose of this study is to determine the long term safety and preliminary efficacy of intramedullary transplantation of HuCNS-SC cells in subjects with thoracic spinal cord trauma.","s":"Terminated","tr":["Observational"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01725880"},{"n":"NCT07227285","t":"Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy","d":"The aim of this study is to continue following participants who have received EG110A during five years to know how it is tolerated in humans, any side-effects it may cause and what might be an effective dose over five years. All participants who have received at least one dose/injection of EG110A in a previous clinical study of EG110A will be asked to roll-over to this long-term follow-up study upon either early discontinuation from, or completion of, that study.","s":"Not yet recruiting","tr":["Drugs"],"o":["Bladder Function"],"st":["California","Michigan","Pennsylvania","Texas"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07227285"},{"n":"NCT00876837","t":"Long-term Outcomes and Life Satisfaction of Adults With Pediatric-Onset Spinal Cord Injuries","d":"The purpose of this study is to assess life satisfaction and long-term outcomes (i.e., medical and psychosocial) of adults who sustained spinal cord injuries (SCI) as children or adolescents.","s":"Completed","tr":["Observational"],"o":["Mental Health","Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00876837"},{"n":"NCT03104803","t":"Long-term Paired Associative Stimulation as a Treatment for Incomplete Spinal Cord Injury of Non-traumatic Origin","d":"The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete SCI of non-traumatic origin.","s":"Completed","tr":["Devices"],"o":["Motor Function"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03104803"},{"n":"NCT03045744","t":"Long-term PAS in Rehabilitation After SCI","d":"The investigators have recently shown in two pilot incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1). In this study, the investigators will administer long-term paired associative stimulation to incomplete SCI patients in a long-term manner, keeping each patient in the study for as long as continuous improvement is observed.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Motor Function"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03045744"},{"n":"NCT03069222","t":"Longitudinal Assessment of Spinal Cord Structural Plasticity Using DTI in SCI Patients","d":"This study will apply novel magnetic resonance imaging (MRI) techniques to investigation of spinal cord injury (SCI) to learn how nerve fibers repair and neural cells regain ability to control muscle during the rehabilitation. The information gained will be helpful for physicians to make more accurate diagnosis of SCI, predict injury recovery and movement restoration, and develop more effective treatment plans.","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Plasticity","Quality of Life","Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03069222"},{"n":"NCT07210437","t":"Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI","d":"The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.","s":"Recruiting","tr":[],"o":["Blood Pressure","Trunk Control"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07210437"},{"n":"NCT02149511","t":"Longitudinal Morphometric Changes Following SCI","d":"In patients with chronic spinal cord injury, imaging of the spinal cord and brain above the level of the lesion provides evidence of neural degeneration; however, the spatial and temporal patterns of progression and their relation to clinical outcomes are uncertain. New interventions targeting acute spinal cord injury have entered clinical trials but neuroimaging outcomes as responsive markers of treatment have yet to be established. We aim to use MRI to assess neuronal degeneration above and…","s":"Completed","tr":["Observational"],"o":["Regeneration"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02149511"},{"n":"NCT04881565","t":"Losing Balance to Prevent Falls After Spinal Cord Injury (RBT+FES)","d":"Falls are a health crisis that cost health care systems billions of dollars/year. This crisis is especially relevant for individuals living with incomplete spinal cord injury (iSCI); 78% fall at least once annually. In able-bodied individuals, falls are prevented by taking reactive steps; however, these reactions are impaired after iSCI. Research in stroke and geriatric rehabilitation showed that reactive balance training (RBT), which targets reactive stepping, prevents falls. We developed a…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Motor Function","Sensory Function","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04881565"},{"n":"NCT03207841","t":"Low Carbohydrate/High Protein Diet to Improve Metabolic Health","d":"Individuals with spinal cord injury (SCI) are living to ages when metabolic disorders are highly prevalent. The combination of impaired glucose tolerance and insulin resistance can disrupt lipid metabolism and increase the risk of cardiovascular disease and diabetes, and contribute to an accelerated aging process in the SCI population. Feasible interventions to improve metabolic function in the chronic SCI are in great demand. Compared to pharmacologic therapies, dietary modification is a more…","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03207841"},{"n":"NCT01943201","t":"Low Friction Bed Sheet","d":"Introduction: It is known that people with spinal cord injury (SCI) bear a considerably increased risk of developing pressure ulcer, whereby frictional forces and shear forces are recognized as risk factors. It was the aim of the study to examine the effects of a specially developed low-friction hospital bed sheet on skin physiology as well as it's acceptance by patients with SCI. Method: Prospective, randomised crossover study. Patients with a subacute spinal cord injury will be recruited…","s":"Completed","tr":["Devices"],"o":["Mental Health","Pressure Sores"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01943201"},{"n":"NCT06521723","t":"Low Oxygen Therapy to Enhance Walking Recovery After SCI.","d":"The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.","s":"Recruiting","tr":["Intermittent Hypoxia","Rehabilitation","Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Florida","Massachusetts"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06521723","su":"https://scitrials.org/trial/NCT06521723"},{"n":"NCT07645027","t":"Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer in Patient With Cervical Spinal Cord Injuries","d":"This randomized clinical trial aims to evaluate the effectiveness of combining Low Volume Nose Resistance Breathing Exercises (LVNRBE) with Incentive Spirometry (IS) on respiratory outcomes in patients with cervical spinal cord injury (SCI). Respiratory complications are a major concern in cervical SCI due to impaired respiratory muscle function, leading to reduced lung volumes, dyspnea, ineffective cough, and sputum retention. The study will recruit 42 inpatients aged 18-38 years with cervical…","s":"Recruiting","tr":["Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07645027","su":"https://scitrials.org/trial/NCT07645027"},{"n":"NCT05334342","t":"Low-GI Diet Vs High-GI Diet in Individuals with SCI","d":"The purpose of this pilot research project is to examine the impact of a low-glycemic index (GI) diet on postprandial hypotension and glucose control in individuals with chronic spinal cord injury. The objectives are: 1) To evaluate the effect of the low-GI diet on the magnitude of postprandial systolic blood pressure drop compared to a high-GI control diet. 2)To evaluate the effect of a low-GI diet on postprandial glucose and insulin responses compared to a high-GI control diet.","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05334342"},{"n":"NCT04032314","t":"Lower Extremity Outcome Measures in SCI","d":"Lower extremity (LE) function of patients with a spinal cord injury (SCI) will be assessed in an observational project with a cross-sectional and a longitudinal study design. The main goal is to identify kinematic and kinetic parameters to precisely characterize LE function and in parallel the impairment and limitation in SCI patients throughout rehabilitation in acute patients and in chronic patients to define LE function and LE recovery.","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Leg Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04032314"},{"n":"NCT02635893","t":"Lower Limb Function After Spinal Cord Injury","d":"This is a randomized, experimental study that examines the physiology of central nervous system pathways contributing to the control of bilateral movements in individuals with spinal cord injuries and promotes the recovery of lower-limb motor function through the use of stimulation and locomotor training.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Leg Movement","Motor Function","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02635893"},{"n":"NCT07128901","t":"Lower-Limb Exoskeleton Technology for Non-Ambulatory Individuals With Spinal Cord Injury","d":"The purpose of this study is to compare two types of wearable lower-extremity exoskeletons -a self-balancing device lower-extremity exoskeleton and a user-balancing device lower-extremity exoskeleton-to better understand their effects on the physiological responses to walking and the user experience in people with spinal cord injury.","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Leg Movement","Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07128901"},{"n":"NCT05919563","t":"LTFU Study of Subjects Who Received GRNOPC1","d":"This is a LTFU study for thoracic SCI subjects that were administered GRNOPC1 cells in the main study CP35A007.","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":["California","Georgia","Illinois"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05919563"},{"n":"NCT05975424","t":"LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1","d":"This is a LTFU study for cervical SCI subjects that were administered AST-OPC1 cells in the main study AST-OPC1-01.","s":"Active, not recruiting","tr":["Observational","Stem Cells"],"o":[],"st":["California","Georgia","Illinois","Pennsylvania","Wisconsin"],"co":["United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05975424","su":"https://scitrials.org/trial/NCT05975424"},{"n":"NCT00378664","t":"Lumbar to Sacral Ventral Nerve Re-Routing","d":"To assess the level of improvement in voiding function after lumbar to sacral ventral nerve re-routing procedure in Spinal Cord Injury and spina bifida patients","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life","Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00378664"},{"n":"NCT06531317","t":"Machine-Learning Based EEG Biomarkers for Personalized Interventions","d":"The goal of this observational study is to develop a machine learning model to predict the outcome of a transcranial direct current stimulation (tDCS) treatment in patients suffering from neuropathic pain derived from a spinal cord injury. The main question it aims to answer is: • Can electroencephalography (EEG) and clinical assessment data predict the success of tDCS treatment in neuropathic pain patients? Participants will: * Undergo EEG recording sessions to collect brain activity data…","s":"Unknown","tr":["Brain Stimulation"],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06531317","su":"https://scitrials.org/trial/NCT06531317"},{"n":"NCT05934968","t":"Mad Dog Cooking Class Series: Effects on Dietary Self-efficacy, Eating Behaviors and Health Outcomes","d":"Spinal cord injury (SCI) and multiple sclerosis (MS) are both conditions characterized by chronic inflammation as indicated by elevated levels of circulating pro-inflammatory cytokines. These cytokines can have a wide array of negative impacts such as increasing the risk of depression and the intensity and frequency of neuropathic pain. Recent work in the investigator's laboratory has shown that a 3-month anti-inflammatory diet is not only effective in reducing pro-inflammatory cytokines, but…","s":"Unknown","tr":["Nutrition"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05934968","su":"https://scitrials.org/trial/NCT05934968"},{"n":"NCT06309888","t":"Magnetic Resonance Imaging of Cognitive Deficits in the Brain of Individuals With Spinal Cord Injury","d":"In the case of spinal cord injury, rehabilitation is particularly focused on motor skills. Non-motor impairments such as thinking difficulties did not receive a lot of attention to date. In this research project, the investigators want to find out how thinking difficulties become noticeable in the brain with spinal cord injury. Participation procedure: Participants who take part will be asked to come to an examination once. The duration of the examination is between 2 and 2.5 hours (including…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06309888"},{"n":"NCT01382290","t":"Magnetic Resonance Imaging of the Spine","d":"Diffusion-weighted (DW) magnetic resonance imaging (MRI) imaging is a well established method for detecting acute injury to the brain and is used on all children undergoing an MRI brain scan at Children's Healthcare of Atlanta. The possibility of using DW MRI to study other areas of the body, such as the spinal cord, has been recognised as having great clinical potential. However, two main problems have hindered the clinical application of the technique; firstly, the extreme motion sensitivity…","s":"Withdrawn","tr":[],"o":["Breathing Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01382290"},{"n":"NCT00001361","t":"Magnetic Resonance Imaging Studies of Motor and Thought Processes","d":"Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI is especially useful when studying the brain, because it can provide information about certain brain functions. In addition, MRI is much better than standard X-rays at showing areas of the brain close to the skull and detecting changes in the brain associated with neurological diseases. In this study researchers will use MRI to gather information…","s":"Completed","tr":["Observational"],"o":["Motor Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00001361"},{"n":"NCT02135978","t":"Maintenance of Shoulder Health and Function After Spinal Cord Injury","d":"The purpose of this study is to determine if a shoulder exercise program can prevent the onset of shoulder pain and improve community participation in persons who have a spinal cord injury (SCI). Upon entry into the study patients will have pain-free shoulders and will be followed for 3 years to determine rate of shoulder pain development. Patients will learn a simple shoulder home exercise program and will be instructed on techniques to protect their shoulder during wheelchair propulsion…","s":"Completed","tr":[],"o":["Pain Management","Quality of Life"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02135978"},{"n":"NCT01467869","t":"Male Fertility Program","d":"Following spinal cord injury, most men are infertile and require medical assistance to father children. The conditions that contribute to their infertility are erectile dysfunction, ejaculatory dysfunction, and semen abnormalities. The Miami Project Male Fertility Program is a research study designed to understand and improve impairments to male fertility resulting from spinal cord injury.","s":"Recruiting","tr":[],"o":["Sexual Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01467869","su":"https://scitrials.org/trial/NCT01467869"},{"n":"NCT04991415","t":"Manual Therapy for the Treatment of Shoulder Pain for Overuse Syndrome Wheelchair Dependent Persons","d":"Shoulder pain is a common, debilitating problem for persons with Spinal cord injuries (SCI). Shoulder pain affects approximately 40-50% of the total population of persons with paraplegia (those with SCI with full use of their upper extremities and no or limited use of their lower extremities). Among the etiologies of shoulder pain in persons with paraplegia, overuse syndrome is the most common. Shoulder overuse syndrome in a person with paraplegia is the result of high activity demands and high…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Pain Management","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04991415"},{"n":"NCT04741126","t":"Manually Assisted Cough Technique and Incomplete Cervical Spine Injury","d":"To determine the effectiveness of manually assisted cough technique on peak cough flow and pulmonary functions in patients with incomplete cervical spine injury. Previous studies were designed to target only a small sample. Level and American Spinal Cord Injury Association (ASIA) scale were not specified so this study covers this aspect.","s":"Completed","tr":[],"o":["Breathing Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04741126"},{"n":"NCT02232165","t":"Mean Arterial Blood Pressure Treatment for Acute Spinal Cord Injury","d":"Current guidelines for the clinical management of acute spinal cord injury (SCI) recommend maintenance of mean arterial blood pressure (MAP) at 85 to 90 mmHg for the first seven days after SCI as a clinical option. Unfortunately, the medical evidence to support this recommendation exists only at the clinical case series level (Class III data). Furthermore, maintenance of sustained systemic hypertension, as per clinical guidelines, may be associated with risks to the patient via adverse medical…","s":"Terminated","tr":[],"o":["Blood Pressure","Motor Function","Quality of Life","Sensory Function"],"st":["Texas"],"co":["Canada","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02232165"},{"n":"NCT01758692","t":"Measurement of Autonomic Cardiovascular Integrity in Persons With SCI","d":"People with a spinal cord injury (SCI) have limited ability to move and feel sensation below the level of the SCI. Doctors and researchers have tests which determine the level of function and sensation, this test was developed by the American Spinal Cord Injury Association (ASIA) and has been modified over the years to improve use and sensitivity. Most recently, the ASIA Injury classification Scale (AIS) was modified in 2011, but this test does not include the evaluation of autonomic nervous…","s":"Completed","tr":["Observational"],"o":["Blood Pressure","Breathing Function","Sensory Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01758692"},{"n":"NCT00172289","t":"Measurement of Pulse Wave Velocity in Spinal Cord Injury and Stroke Patients","d":"According to the theory of wave transmission, the speed of wave transmission is dependent on the nature of the transmission medium, which is the vessel wall for pulse wave transmission. Then, the pulse wave velocity is related to the mechanical property of the vessel wall. The mechanical property of the vessel wall is determined by the texture of the vessel wall and the contraction status of the smooth muscle within the vessel wall. Because the texture of the vessel wall could not be changed in…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00172289","su":"https://scitrials.org/trial/NCT00172289"},{"n":"NCT01117090","t":"Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery","d":"The purpose of this study is to record signatures from the fluid surrounding the spinal cord from people who have an implanted drug infusion system.","s":"Completed","tr":["Devices","Drugs","Observational"],"o":["Breathing Function"],"st":["Indiana","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01117090"},{"n":"NCT05183113","t":"Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI","d":"This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention. Acquiring these scans in patients with chronic cervical spinal cord injury and uninjured controls will enable characterization of changes in neurovascular physiology caused by this promising new therapy.","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Hand Movement"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05183113"},{"n":"NCT03914677","t":"Mecamylamine for Autonomic Dysreflexia Prophylaxis","d":"This is a preliminary study of the antihypertensive drug mecamylamine, used in the specific circumstance of hypertension caused by autonomic dysreflexia (AD), a condition that affects people with spinal cord injury (SCI). Initially, mild sensory stimulation of subjects' legs is used to intentionally provoke AD, as reflected by blood pressure elevation during such stimulation. In subsequent testing sessions, mecamylamine is given prior to sensory stimulation, to show the effect of the drug on…","s":"Unknown","tr":[],"o":["Blood Pressure"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03914677","su":"https://scitrials.org/trial/NCT03914677"},{"n":"NCT02154412","t":"Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury","d":"This clinical study is designed to investigate the mechanisms of blood pressure regulation and respiratory motor function affected by spinal cord injury (SCI). We hypothesize that impaired blood pressure regulation in individuals with chronic SCI can be improved by restoring respiratory motor function by using Respiratory Motor Training (RMT).","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Motor Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02154412"},{"n":"NCT00001661","t":"Mechanisms of Human Plasticity in the Human System","d":"The purpose of this study is to investigate the physiology associated with plasticity of the motor system. Plasticity refers to the process by which neighboring brain cells assume the responsibilities of damaged or diseased brain cells. The mechanisms behind this process are unknown. However, researchers have several theories about how plastic changes take place. Possible explanations include the growth of new connections between brain cells and the use of previously unused connections…","s":"Completed","tr":["Drugs","Observational","Transcranial Magnetic Stimulation (TMS)"],"o":["Plasticity"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00001661"},{"n":"NCT00175773","t":"Mechanisms of Orthostatic Intolerance in Spinal Cord Injured Individuals and Following Bed Rest","d":"The primary purpose of this study is to investigate the relationship between the extent of neurologic (nerve) impairment in patients with spinal cord injuries and how well the nerves passing down the spine to the heart and blood vessels are working. These nerves are called the descending spinal sympathetic pathway (DSSP) and are important in controlling many functions, including blood pressure. We also wish to examine how injury severity and DSSP function influence blood levels of…","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00175773"},{"n":"NCT02333695","t":"Medical Device for Magnetic Therapy for Spinal Cord Injuries (SCI)","d":"A medical device for magnetic therapy for spinal cord injuries (SCI) will be disclosed. The apparatus comprises a combination of several magnets enclosed in a supportive cover. The magnets are placed in a proper position and their polarity can be changed at any time without any difficulty.","s":"Unknown","tr":["Devices"],"o":["Bladder Function","Bowel Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02333695"},{"n":"NCT00221767","t":"Medico-economical Impact of the Brindley Neurosurgical Technique in France","d":"Bladder dysfunction is a major problem in patients with complete spinal cord lesions. For patients presenting incontinence or risk for kidney, two major conventional alternatives are possible : conservative therapies (muscarinic receptor antagonists, vanilloids drugs and botulinum toxin in association with catheterization) and surgical techniques intervening in the nervous and urinary system. Among these last alternatives, the Brindley technique (anterior sacral root stimulation with posterior…","s":"Completed","tr":["Devices","Surgical Procedure"],"o":["Bladder Function","Bowel Function","Quality of Life","Spasticity"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00221767"},{"n":"NCT06717503","t":"Medico-legality of Acute Spinal Cord Injuries","d":"1. Describe different medico-legal aspects of TSI (mode of trauma, cause and Pattern of spinal injuries). 2. Assess the outcome of TSI in studied cases. 3. Associate type of trauma with the different patterns of acute spinal injuries.","s":"Not yet recruiting","tr":["Observational"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06717503","su":"https://scitrials.org/trial/NCT06717503"},{"n":"NCT03167801","t":"Melatonin Secretion and Sleep Quality in Spinal Cord Injury Patients","d":"To evaluate the relationship between secretion of melatonin and sleep quality in spinal cord injury patients versus a database of healthy volunteers.","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03167801"},{"n":"NCT01302522","t":"Mental Practice Impact on Gait and Cortical Organization in Spinal Cord Injury (SCI)","d":"Spinal cord injury (SCI) is a disabling condition that impairs fundamental abilities, such as ambulation, respiration, and toileting. Compromised ambulation is a common, devastating impairment following SCI. Yet, despite the fundamental desire to walk, no conventional rehabilitation regimen reliably improves ambulation after SCI, and many SCI patients do not have reliable transportation access, decreasing community integration and access to needed services, including rehabilitation. Little is…","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function","Quality of Life","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01302522"},{"n":"NCT06989905","t":"MEP Up-conditioning to Target Corticospinal Plasticity","d":"Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06989905","su":"https://scitrials.org/trial/NCT06989905"},{"n":"NCT01446640","t":"Mesenchymal Stem Cells Transplantation to Patients With Spinal Cord Injury","d":"The study is a phase I/II trial designed to establish the safety and efficacy of intravenous combined with intrathecal administration of autologous bone marrow derived mesenchymal stem cells to patients with spinal cord injury.","s":"Unknown","tr":["Stem Cells"],"o":["Motor Function","Sensory Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01446640","su":"https://scitrials.org/trial/NCT01446640"},{"n":"NCT03204240","t":"Metabolic Health in Individuals With Spinal Cord Injury (SCI)","d":"Individuals with spinal cord injury (SCI) live longer than before and live to an age where metabolic disorders become highly prevalent. Due to loss of mobility and severe skeletal muscle atrophy, obesity, glucose intolerance, and peripheral insulin resistance develop soon after the onset of SCI. These abnormalities are thought to contribute to the increased diabetes disease risk and accelerated aging process in the SCI population. As a result of these trends, overall burden of complications…","s":"Completed","tr":["Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":["Motor Function","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03204240"},{"n":"NCT02934594","t":"Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate","d":"Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with palliative decompression.","s":"Unknown","tr":["Observational","Surgical Procedure"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02934594"},{"n":"NCT07272967","t":"Metformin in Preventing Secondary Gliosis Following Acute Thoraco-Lumbar Spinal Cord Injury","d":"Background: Spinal cord injury (SCI) is a major global health problem, with thoraco-lumbar injuries often leading to paraplegia and incomplete neurological recovery. The glial scar, resulting from astrocyte activation at the injury site, constitutes a major barrier to axon regeneration. Given the limitations of current treatments, there is an urgent need for new interventions to improve outcomes. Metformin, a common drug for diabetes, shows promising potential as a neuroprotective agent in…","s":"Not yet recruiting","tr":["Drugs"],"o":[],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07272967","su":"https://scitrials.org/trial/NCT07272967"},{"n":"NCT00004759","t":"Methylprednisolone Given by 24-Hour or 48-Hour Infusion Versus Tirilazad for Acute Spinal Cord Injury","d":"OBJECTIVES: I. Compare the efficacy and safety of 24- versus 48-hour infusion of methylprednisolone (MePRDL) versus tirilazad for patients with acute spinal cord injury. II. Compare neurologic recovery following 24- and 48-hour MePRDL infusions.","s":"Completed","tr":["Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00004759"},{"n":"NCT06077071","t":"Miami \"RADAR\" Trial","d":"The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by pressure (compressed).","s":"Not yet recruiting","tr":["Epidural Stimulation","Surgical Procedure"],"o":["Quality of Life","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06077071"},{"n":"NCT02034461","t":"Micro-Electrodes Implanted in a Human Nerve","d":"The main objective of the intervention in the study is devise feasibility using high-count microelectrode arrays implanted into peripheral nerves of patients with limb amputations or peripheral nerve injury. These microelectrodes will be custom-made and are not available for commercial distribution. The investigators hypothesize that recording neural signals from a large number of microelectrodes will provide selective motor information in high enough numbers to allow control over future…","s":"Terminated","tr":["Devices","Surgical Procedure"],"o":["Arm Movement"],"st":["Utah"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02034461"},{"n":"NCT03167138","t":"Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury","d":"Rotator cuff disease (i.e., rotator cuff tendinopathy or tear) is a common cause of shoulder pain in persons with chronic spinal cord injury (SCI). It usually resolves with non-operative treatments such as pharmacological agents and physical therapy; however, when this fails, rotator cuff surgery may be the only option. Autologous adipose tissue injection has recently emerged as a promising new treatment for joint pain and soft tissue injury. Adipose can be used to provide cushioning and…","s":"Unknown","tr":[],"o":["Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03167138","su":"https://scitrials.org/trial/NCT03167138"},{"n":"NCT01364480","t":"Microelectrode Brain-Machine Interface for Individuals With Tetraplegia","d":"The purpose of this research study is to demonstrate the safety and efficacy of using two NeuroPort Arrays (electrodes) for long-term recording of brain activity.","s":"Terminated","tr":["Brain Machine Interface (BMI)","Devices"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01364480"},{"n":"NCT04189172","t":"MiDura-Study (Neuro-Patch in Duraplasty)","d":"The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer","s":"Active, not recruiting","tr":["Observational","Surgical Procedure"],"o":[],"st":[],"co":["France","Germany"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04189172"},{"n":"NCT03736382","t":"Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea","d":"Mild intermittent hypoxia (IH) initiates sustained increases in chest wall and upper airway muscle activity in humans. This sustained increase is a form of respiratory plasticity known as long-term facilitation (LTF). Repeated daily exposure to mild IH that leads to the initiation of LTF of upper airway muscle activity could lead to increased stability of the upper airway. In line with PI's laboratory's mandate to develop innovative therapies to treat sleep apnea, this increased stability could…","s":"Unknown","tr":["Intermittent Hypoxia"],"o":["Blood Pressure","Breathing Function","Plasticity"],"st":["Michigan"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT03736382"},{"n":"NCT05351827","t":"Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries","d":"The prevalence of autonomic dysfunction and sleep disordered breathing (SDB) is increased in individuals with spinal cord injury (SCI). The loss of autonomic control results in autonomic dysreflexia (AD) and orthostatic hypotension (OH) which explains the increase in cardiovascular related mortality in these Veterans. There is no effective prophylaxis for autonomic dysfunction. The lack of prophylactic treatment for autonomic dysfunction, and no best clinical practices for SDB in SCI, are…","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Blood Pressure"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05351827","su":"https://scitrials.org/trial/NCT05351827"},{"n":"NCT04020562","t":"Mild Resistive Expiratory Breathing Technique On Spinal Cord Injury","d":"Studies have been conducted on the effectiveness of inspiratory muscle training on tetraplegics, and less has been reported on expiratory muscle training on paraplegics; especially in Pakistan there was no such study done up-to my knowledge. Paraplegic individuals develop pulmonary complications due to prolonged general immobilization of body and ineffective cough due to respiratory muscle weakness. This study will identify the effects of expiratory muscle training using \"Expiratory Muscle…","s":"Completed","tr":[],"o":["Breathing Function","Motor Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04020562"},{"n":"NCT05936619","t":"MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System","d":"This research study is being done to develop a novel brain-computer interface (BCI) technology that can enable severely paralyzed individuals to interact with the world through direct brain-control of a computer. This technology is named MindEx (for Mind Extender). It utilizes four implanted \"chips\" in the human brain from which investigators can record brain activity during subjects' thoughts and decode meaningful information from this activity to be used as control signals for a computer, a…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05936619","su":"https://scitrials.org/trial/NCT05936619"},{"n":"NCT03207737","t":"Mindfulness, Exercise and Nutrition To Optimize Resilience for Individuals With a Spinal Cord Injury.","d":"The purpose of this study is to examine the effects of onsite and telehealth programs for individuals with spinal cord injury. The primary aim of this study is to compare the effectiveness of a blended 5-day onsite health promotion program followed by a 12-month telehealth package composed of exercise, nutrition, and mindfulness, to a 12-month telehealth-only package in individuals with spinal cord injury. The investigators hypothesize that the blended onsite and telehealth program will achieve…","s":"Completed","tr":["Nutrition"],"o":["Mental Health","Pain Management"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03207737"},{"n":"NCT00559494","t":"Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury","d":"While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies. We propose to investigate the drug Minocycline (a metalloproteinase inhibitor) for the treatment of spinal cord injured patients aiming to limit neurological injury and improve neurological outcome. This drug influences several secondary injury mechanisms implicated in spinal cord injury and has been effective in improving outcome after spinal…","s":"Completed","tr":["Drugs","Safety"],"o":["Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00559494"},{"n":"NCT01828203","t":"Minocycline in Acute Spinal Cord Injury (MASC)","d":"The objective of this study is to assess the efficacy of IV minocycline in improving neurological and functional outcome after acute non-penetrating traumatic spinal cord injury (SCI). The primary hypothesis is that intravenous minocycline twice daily (800 mg initial dose tapered to 400 mg by 100 mg at each dose then administered to the end of day 7) administered to subjects with acute traumatic non-penetrating cervical SCI starting within 12 hours of injury will improve motor recovery as…","s":"Unknown","tr":["Drugs"],"o":[],"st":[],"co":["Australia","Canada"],"lc":7,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT01828203","su":"https://scitrials.org/trial/NCT01828203"},{"n":"NCT03187795","t":"Mirabegron and Oxybutynin Safety and Efficacy Trial in Spinal Cord Injury","d":"The purpose of this research study is to determine the effectiveness and safety of mirabegron compared to oxybutynin chloride immediate release (oxybutynin IR) for a condition called neurogenic detrusor overactivity in individuals with chronic spinal cord injury (SCI).","s":"Unknown","tr":[],"o":["Bladder Function"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03187795","su":"https://scitrials.org/trial/NCT03187795"},{"n":"NCT03098927","t":"Mirror Neuron Network Based Motor Imagery Training to Improve Brain Computer Interface Performance in Spinal Cord Injury Patients","d":"The overall vision of this proposal is to demonstrate that a virtual reality based motor imagery training program will improve brain computer interface (BCI) performance and motor function in quadriplegic subjects. The ultimate goal is to increase the independence of subjects with spinal cord injury by training to safely control BCI assistive devices and to enhance motor recovery.","s":"Withdrawn","tr":["Brain Machine Interface (BMI)"],"o":["Motor Function","Quality of Life"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03098927"},{"n":"NCT03987243","t":"Mobile and Remote Monitoring of Seating Pressure for Wheelchair Users With SCI","d":"This study will examine two interventions to increase weight shifts, overall trunk movement, and self-efficacy related to pressure ulcer prevention in wheelchair users with a spinal cord injury (SCI).","s":"Completed","tr":[],"o":["Pressure Sores","Trunk Control"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03987243"},{"n":"NCT02592291","t":"Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions","d":"This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to those who receive standard of care only.","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02592291","su":"https://scitrials.org/trial/NCT02592291"},{"n":"NCT04668326","t":"Mobile Manual Standing Wheelchair for SCI","d":"People with spinal cord injuries (SCI) are particularly prone to complications from excessive sitting, because many are not able to stand without support. Excessive sitting after SCI is believed to contribute to pressure injuries, pain, osteoporosis, joint stiffness, spasticity, and worsening bowel and bladder function. The VA has developed, patented, and licensed a mobile manual standing wheelchair (MMSW), and the investigators believe the key feature of being able to wheel around while in a…","s":"Completed","tr":["Devices"],"o":["Bladder Function","Bone Strength","Bowel Function","Pain Management","Pressure Sores","Spasticity"],"st":["California","Minnesota"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04668326"},{"n":"NCT03082898","t":"Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Clinical Setting (SC140121 Study 1 and 2)","d":"The proposed study is intended to inform the hypotheses that (1) regular dosing of exoskeleton walking will provide health benefits to non-ambulatory and poorly-ambulatory individuals with SCI, including decreased pain and spasticity, improvements in bowel and bladder function, decreased body-mass index (BMI), enhanced well-being; (2) regular dosing of exoskeleton walking will facilitate neurological or functional recovery in some individuals with SCI, particularly those with incomplete…","s":"Completed","tr":["Exoskeleton"],"o":["Bladder Function","Bowel Function","Leg Movement","Mental Health","Pain Management","Spasticity","Walking Function"],"st":["Florida","Minnesota","Tennessee"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03082898"},{"n":"NCT04149769","t":"Mobility and Therapeutic Benefits Resulting From Exoskeleton Use in a Home and Community Setting (SC140121 Study 3)","d":"The proposed study is a pilot study intended to inform the hypothesis that regular walking in an exoskeleton within the home and community might offer health benefit, neurological recovery, and/or mobility benefit to the user. This exploratory pilot study is also intended to assess the level of compliance (i.e., exoskeleton use) among study participants by characterizing extent the device is used beyond the minimum required.","s":"Withdrawn","tr":["Devices","Exoskeleton"],"o":["Bone Strength","Quality of Life","Spasticity","Walking Function"],"st":["Florida","Minnesota","Tennessee"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04149769"},{"n":"NCT04453943","t":"Modeling, Optimization, and Control Methods for a Personalized Hybrid Walking Exoskeleton","d":"The central objective of this study is to validate new algorithms that coordinate between functional electrical stimulation (FES) and the exoskeleton during sitting-to-standing, walking, and standing-to-sitting movements. The secondary objective is to optimize the algorithms as well as assess their ability to reduce FES-induced muscle fatigue by using ultrasound imaging as a sensing modality. This study will include persons with no disabilities and persons with Spinal Cord Injury (SCI). A…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04453943","su":"https://scitrials.org/trial/NCT04453943"},{"n":"NCT04581525","t":"Modulating Neuropathic Pain With Transcranial Direct Current Stimulation","d":"This study will examine whether a form of non-invasive brain stimulation can help reduce pain in people with persistent neuropathic pain.","s":"Terminated","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04581525"},{"n":"NCT07383077","t":"Molecular Determinants of Spinal Cord Injury Rehabilitation","d":"This study main aim is to identify molecular determinants of better recovery following spinal cord injury (SCI), as biomarkers of neurological and/or functional improvement and a proxy for neuroregeneration. For that, omics analyses of several biological samples will be performed, to comprehensively portray the molecular and cellular profiles of the patients with SCI at key time points of the pathology: pre-rehabilitation, post-rehabilitation and one-year post-injury. The main question it aims…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":["Portugal"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07383077"},{"n":"NCT01538693","t":"Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury","d":"The purpose of this study is to determine whether exercising (walking) at different intensities increases levels of factors in the blood and saliva that are known to impact neuroplasticity (how the connections in the spinal cord and brain can change) and if these levels are changed by pairing exercise with a single dose of commonly used prescription drugs or by your mood.","s":"Completed","tr":["Drugs"],"o":["Leg Movement","Mental Health","Motor Function","Plasticity","Spasticity","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01538693"},{"n":"NCT01753882","t":"Monoaminergic Modulation of Motor Function in Subacute Incomplete Spinal Cord Injury (SCI)","d":"The primary goal of the proposed clinical trial is to investigate the combined effects of walking training and monoaminergic agents (SSRIs and TIZ) on motor function of individuals in sub-acute (2-7 mo) human motor incomplete Spinal Cord Injury (SCI), with a primary emphasis on improvement in locomotor capability. We hypothesize that the use of these drugs applied early following SCI may facilitate independent stepping ability, and its combination with intensive stepping training will result in…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01753882","su":"https://scitrials.org/trial/NCT01753882"},{"n":"NCT05032378","t":"Motion Sensor and Feedback System Efficacy to Refine Movements After Injury","d":"The purpose of these case studies is to determine the efficacy of the Kinesthetic Awareness Training (KAT) device in facilitating the restoration of desired movement patterns when people with acquired central nervous system damage perform functional activities such as walking, transitioning from one position to another, or reaching with the arms.","s":"Unknown","tr":["Devices","Observational","Rehabilitation"],"o":["Arm Movement","Walking Function"],"st":["Nebraska"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05032378"},{"n":"NCT00947232","t":"Motivational Interviewing to Increase Physical Activity to Treat Depression in People Aging With MS or SCI","d":"This study compares two approaches to helping people who are aging with MS or SCI and are experiencing depressed mood to become more physically active. The study is carried out entirely by telephone. There is no need to travel and participants may reside anywhere within the United States. We will examine the effects of the intervention on overall physical activity, mood, pain, fatigue and general health. Participants will complete surveys over the phone throughout the study and wear an activity…","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00947232"},{"n":"NCT07179822","t":"Motoneuron Recruitment and Motor Evoked Potential Up-Conditioning (MEP) in Spinal Cord Injury (SCI)","d":"The purpose of this research study is to examine the effect of a brain stimulation training to improve the function of brain-spinal cord- muscle connections. Because brain-to-muscle pathways are very important in our movement control, restoring function of these pathways may improve movement problems after injuries. Spinal cord injury causes damage to the brain-to-muscle connection. However, when the injury is \"incomplete\", there is a possibility that some of the brain-to-muscle pathways are…","s":"Recruiting","tr":["Transcranial Magnetic Stimulation (TMS)"],"o":[],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07179822","su":"https://scitrials.org/trial/NCT07179822"},{"n":"NCT04726059","t":"Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT","d":"Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population. Mobility impairments and secondary complications limit an individual's ability to exercise, a behavior known to have wide-ranging functional and health benefits. This trial will investigate whether activity-based therapy (ABT), using body-weight-supported treadmill training (BWSTT), can…","s":"Unknown","tr":["Exoskeleton","Transcutaneous Stimulation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04726059","su":"https://scitrials.org/trial/NCT04726059"},{"n":"NCT04367623","t":"Motor Conditioning to Enhance the Effect of Physical Therapy","d":"Spinal Cord Injury (SCI) affects person's ability to move and feel sensation from the body. About half of patients with tetraplegia (high level SCI) have an incomplete injury, i.e. have some sensation and control of muscles preserved and could recover some function of their upper limbs. In this study the researchers would like to increase the effect of physical therapy of the upper limbs by sensory-motor priming. To achieve this they will use Brain Computer Interface (BCI) controlled Functional…","s":"Terminated","tr":["Brain Machine Interface (BMI)","Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04367623"},{"n":"NCT02860403","t":"Motor Imagery for Reach-to-grasp Rehabilitation After Tetraplegia","d":"Single center, pilot study, to evaluate the influence of Motor Imagery (MI) on functional rehabilitation and cerebral plasticity through the qualitative and quantitative mental practice approach. For this, the investigators will use magnetoencephalography (MEG) but also physiological and behavioral indicators developed by the Laboratoire de la Performance Motrice, Mentale et du Matériel (P3M) of Université Claude Bernard Lyon 1 and its partners.","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement","Plasticity"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02860403"},{"n":"NCT07549087","t":"Motor Imagery Reaction Time in Individuals With Paraplegic Spinal Cord Injury","d":"Individuals aged 18-65 years who have been clinically diagnosed with spinal cord injury and have developed paraplegia will be included in the study. Demographic and clinical data of the participants, including age, sex, height, weight, etiology of injury, level of injury, duration of injury, and comorbidities, will be recorded. In addition, disease-specific characteristics such as ambulation status, wheelchair use, presence of incontinence, and presence and severity of pain will be assessed…","s":"Not yet recruiting","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07549087","su":"https://scitrials.org/trial/NCT07549087"},{"n":"NCT03781609","t":"Motor Learning Approach for Manual Wheelchair Users","d":"The overall purpose of this project is to pilot test a manual wheelchair (MWC) training program based on motor learning theory to improve wheelchair propulsion for manual wheelchair users (MWUs) with spinal cord injury (SCI).","s":"Completed","tr":[],"o":["Walking Function"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03781609"},{"n":"NCT01608438","t":"Motor Learning in a Customized Body-Machine Interface","d":"People with tetraplegia often retain some level of mobility of the upper body. The proposed study will test the hypothesis that it is possible to develop personalized interfaces, which utilize the residual mobility to enable paralyzed persons to control computers, wheelchairs and other assistive devices. If successful the project will result into the establishment of a new family of human-machine interfaces based on wearable sensors that adapt their functions to their users' abilities.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01608438","su":"https://scitrials.org/trial/NCT01608438"},{"n":"NCT04017767","t":"Motor Plasticity, Intermittent Hypoxia and Sleep Apnea","d":"The purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04017767","su":"https://scitrials.org/trial/NCT04017767"},{"n":"NCT04688229","t":"Motor Recovery Training for Hand and Digits in Stroke and SCI","d":"This study will use evaluate a hand therapy device training isolated finger control with engaging video gaming technology to facilitate hand and digit recovery in patients with acute stroke and cervical spinal cord injury. This study will randomize patients to either standard rehabilitation care with added study-related motor training or standard rehabilitation care alone.","s":"Unknown","tr":["Rehabilitation"],"o":["Hand Movement"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04688229","su":"https://scitrials.org/trial/NCT04688229"},{"n":"NCT03441256","t":"Motor, Sensory, and Autonomic Function in Traumatic Spinal Cord Injury After the LION Procedure.","d":"Possover pioneered a minimally invasive and fully reversible laparoscopic technique, laparoscopic implantation of neuroprosthesis (LION), for precise placement of an implantable pulse generator and one to four leads for stimulating nerves of the lumbosacral plexus. Unexpectedly, Possover in 2014 made the clinical observation that four patients with complete and incomplete chronic traumatic spinal cord injury regained significant motor and sensory function following the LION procedure for…","s":"Completed","tr":["Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":["Bladder Function","Bowel Function","Pain Management","Quality of Life","Sensory Function","Spasticity","Walking Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03441256"},{"n":"NCT03797378","t":"Movement-2-Music: Lakeshore Examination of Activity, Disability, and Exercise Response Study","d":"The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants with physical/mobility disabilities will be recruited and randomly enrolled into one of two groups: a) M2M or b) waitlist control. The primary aim of this study is to determine the effects of a 12-week M2M program on health and fitness in participants with…","s":"Completed","tr":[],"o":["Leg Movement","Motor Function","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03797378"},{"n":"NCT03111277","t":"MR Guided Focused Ultrasound for Treatment of Neuropathic Pain","d":"Neuropathic pain is often a result of direct diseases of peripheral or central nervous system with an estimated prevalence of 8% of adults and this pain is associated with significant consequences because of longer symptom duration and severity than many of the other pain syndromes. Functional brain imaging has revealed that many regions of the brain are engaged by painful events, but specific areas such as the thalamus have been markedly implicated. The purpose of this study is to determine…","s":"Completed","tr":["Devices"],"o":["Pain Management"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03111277"},{"n":"NCT00561782","t":"MR Spectroscopy as a Diagnostic and Outcome Measure in Pain and SCI","d":"The goal of this study is to compare the changes that occur in sensation and chemical properties of the brain following SCI between individuals that experience chronic pain and those that do not, and between those with SCI and the able-bodied.","s":"Completed","tr":["Observational"],"o":["Pain Management","Sensory Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00561782"},{"n":"NCT07269977","t":"mSCI: Mobile Health App for Veterans With SCI and Caregivers","d":"Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation. Military caregivers (Family Caregivers of wounded or disabled Veterans) reported similar negative effects of becoming a caregiver on their physical and mental health. Using results from our previous work in mHealth interventions for individuals with SCI, we developed a dual-target…","s":"Recruiting","tr":["Observational","Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07269977"},{"n":"NCT02329652","t":"Multi-functional Neuroprosthetic System for Restoration of Motor Function in Spinal Cord Injury","d":"This study is to evaluate the use of a fully implanted device for providing hand function, reach, and trunk function to individuals with cervical spinal cord injury. Funding Sources: FDA OOPD NIH NINDS","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02329652","su":"https://scitrials.org/trial/NCT02329652"},{"n":"NCT05776030","t":"Multi-speed Ergonomic Wheelchair","d":"Over one million Americans rely on their upper extremities for manual wheelchair propulsion. Shoulder overuse injuries are prevalent among manual wheelchair users and these injuries often result in shoulder pain. Severe shoulder pain can lead some wheelchair users to transition from manual to powered mobility, complicating transportation, and reducing independence in activities of daily living. This project will expand the understanding of a new wheelchair design that allows better positioning…","s":"Recruiting","tr":["Devices"],"o":["Pain Management","Quality of Life"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05776030"},{"n":"NCT02582619","t":"Multidisciplinary Model to Guide Employment Amongst PLWSCI","d":"Spinal cord injury often results in complete or partial loss of functioning of the upper and or lower limbs, leading to the affected individual experiencing difficulties in performing activities of daily living. This in turn results in reduced participation in social, religious, recreational and economic activities (employment). Globally, there is a low employment rate (11-67%) amongst PLWSCI. In South Africa, according to Statistics South Africa, the unemployment rate of people with…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":["South Africa"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02582619"},{"n":"NCT00732238","t":"Multifaceted Treatment of Catheter-related Urinary Tract Infection","d":"The specific objective of this clinical trial is to demonstrate that a multifaceted approach for treatment for catheter-related urinary tract infection (UTI) in patients with spinal cord injury is effective and feasible. We plan to test the following hypothesis: a multifaceted treatment approach that consists of immediate removal of the indwelling bladder catheter, selecting antibiotics based on the finding from a urine culture that is obtained through the newly inserted catheter, and a 5-day…","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00732238"},{"n":"NCT05871697","t":"Multifidus & Gastrocnemius Muscle Thickness & Postural Stability in Spinal Cord Injury Patients: A Correlational Study","d":"This study aims to investigate the relationship between multifidus and gastrocnemius muscle thickness with postural stability in patients with spinal cord injury.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05871697","su":"https://scitrials.org/trial/NCT05871697"},{"n":"NCT07732972","t":"Multilevel Multimodal Neurophysiological Integration for Investigating the Network Modulatory Mechanisms of Epidural Spinal Cord Stimulation","d":"This study will examine how the brain, spinal cord, and muscles communicate in people with spinal cord injury. Researchers will use noninvasive brain and muscle recordings together with spinal electrical recordings to better understand how epidural spinal cord stimulation (EES) affects nerve function. The results may help develop more effective and personalized rehabilitation treatments for people with spinal cord injury.","s":"Recruiting","tr":["Electrical Stimulation","Epidural Stimulation","Observational","Rehabilitation"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07732972"},{"n":"NCT01740128","t":"Multimodal Exercises to Improve Leg Function After Spinal Cord Injury","d":"Many people with spinal cord injury (SCI) retain at least some movement below their injury, but their muscles often have a 'mind of their own'. Typical exercise programs focus on keeping muscles strong and flexible, but don't usually focus on helping patients control their muscles. The investigators' exercise research study will compare two different programs with the specific goal of improving conscious control of patients' muscles below the injury. This study focuses on those with 'chronic'…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Motor Function","Pain Management","Spasticity","Trunk Control","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01740128"},{"n":"NCT07739134","t":"Multimodal Tracking of Therapy Activity and Effort During Rehabilitation","d":"This study looks at whether everyday rehabilitation therapy sessions can be recorded and measured in a more complete, objective way. Today, therapists usually document sessions by hand, and the notes can vary a lot from one therapist to another. This makes it hard to track exactly what was done during a session and how much effort it took. In this study, adults receiving neurorehabilitation (for example after a stroke, or with Parkinson's disease, cerebral palsy, spinal cord injury, or ALS)…","s":"Active, not recruiting","tr":["Observational","Rehabilitation"],"o":["Breathing Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07739134"},{"n":"NCT03576001","t":"Multimodality Intervention for Function and Metabolism in SCI","d":"The proposed phase 2 trial a randomized, placebo-controlled, parallel group trial in persons with cervical or thoracic SCI, AIS grade A, B, C, or D, 6 months or later after injury. The trial will test the hypothesis that a Home-Based Multimodality Functional Recovery and Metabolic Health Enhancement Program that addresses multiple pathophysiologic factors in SCI and includes functional electrical stimulation during leg cycling (FES-LC) plus arm ergometry and an androgen will be more efficacious…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03576001","su":"https://scitrials.org/trial/NCT03576001"},{"n":"NCT07204184","t":"Multisite Transspinal Stimulation for Augmenting Recovery in Spinal Cord Injury","d":"A well-established rehabilitation strategy for improvements of standing and walking ability in persons with spinal cord injury (SCI) is step training on a motorized treadmill with body weight support. A promising intervention is stimulation of the spinal cord through the skin (transspinal). No single intervention is likely to significantly improve long-term function after SCI on its own. Rather, combinatorial treatments that work synergistically and can be used at different clinical settings is…","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07204184","su":"https://scitrials.org/trial/NCT07204184"},{"n":"NCT06321172","t":"Muscle and Bone Changes After 6 Months of FES Cycling","d":"The goal of this clinical trial is to assess the effectiveness of FES cycling in terms of changes morpho-functional characteristics of the leg muscles, training performance and bone trophism in 5 subjects with Spinal Cord Injury after 6 months of training. The main question\\[s\\] it aims to answer are: * Do the morpho-functional characteristics of the leg muscles improve after 3 and 6 months of training with FES cycling? If any, the morpho-functional improvements are maintained one month after…","s":"Completed","tr":["Functional Electrical Stimulation (FES)"],"o":["Mental Health","Pain Management","Spasticity"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06321172"},{"n":"NCT06474117","t":"Muscle-tendon Interaction in the Spastic Sural Triceps During Gait","d":"This project aims to study the mechanical behavior of the muscle-tendon unit (MTU) of the gastrocnemius medialis (GM) and the Achilles tendon (AT) in post-stroke and spinal cord injured (SCI) patients compared to a healthy population, focusing on the variations in muscle and tendon length during the stance phase of the gait cycle. The primary objective is to assess the respective contributions of the GM and AT lengthening in the MTU during walking. Inclusion criteria include adult post-stroke…","s":"Completed","tr":["Observational"],"o":["Motor Function","Spasticity","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06474117"},{"n":"NCT02622295","t":"Musculoskeletal Plasticity After Spinal Cord Injury","d":"Patients with spinal cord injury (SCI) experience metabolic syndrome, diabetes, obesity, pressure ulcers, and cardiovascular disease at far greater rates than the general population. A rehabilitation method to prevent or reverse the systemic metabolic consequences of SCI is a pressing need. The purpose of this study is to determine the dose of muscle activity that can enhance an oxidative muscle phenotype and improve clinical markers of metabolic health and bone turnover in patients with SCI…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Plasticity","Quality of Life"],"st":["Iowa"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02622295"},{"n":"NCT05777499","t":"MUSic Therapy In Complex Specialist Neurorehabilitation","d":"Aim: Investigate whether patients undergoing specialist rehabilitation after complex neurological injury show different functional outcomes if music therapy is included in their rehabilitation program compared to usual care. Background: Patients with complex needs following a brain, spinal cord, and/or peripheral nerve injury often require a period of specialist neurorehabilitation. This involves multiple therapy disciplines, led by a Consultant in Rehabilitation Medicine, Neurology, or…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05777499","su":"https://scitrials.org/trial/NCT05777499"},{"n":"NCT02878070","t":"My Care My Call: Peer-Led Health Empowerment Training in Chronic Spinal Cord Injury","d":"My Care My Call (MCMC) is an innovative, peer-led telephone intervention designed to empower adults with chronic spinal cord injury (SCI) in the self-management of their primary health care needs to prevent secondary conditions. In a randomized controlled trial, participants assigned to the MCMC intervention receive tapered calls from a Peer Health Coach (PHC) for six months. PHCs are experienced, empathetic peer mentors living with SCI who act as supporters, role models, and advisors…","s":"Completed","tr":[],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02878070"},{"n":"NCT05553457","t":"MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury","d":"The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.","s":"Recruiting","tr":["Rehabilitation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05553457","su":"https://scitrials.org/trial/NCT05553457"},{"n":"NCT02052024","t":"Myobloc Atrophy Study","d":"The present pilot study is designed to assess the extent to which BOTOX and MYOBLOC cause muscle atrophy in spastic patients. The primary objective is to assess whether there is statistically significant difference in muscle atrophy between the two groups over a one year period.","s":"Completed","tr":["Drugs"],"o":["Spasticity"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02052024"},{"n":"NCT07711015","t":"Myofascial Release and 20-m Speed in Wheelchair Rugby Athletes With Spinal Cord Injury","d":"This study aims to investigate the effect of myofascial release on sprint performance in wheelchair rugby athletes with spinal cord injury. Participants will complete a 20-meter sprint test on two different days in a randomized crossover design: one day without myofascial release and one day immediately after the intervention. The myofascial release will be applied to the upper limb muscles involved in wheelchair propulsion using a handheld device for 90 seconds per muscle group. Sprint…","s":"Not yet recruiting","tr":["Devices"],"o":["Arm Movement"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07711015"},{"n":"NCT05605912","t":"Myosuit in Incomplete Spinal Cord Injury","d":"The Myosuit is a light-weighted lower extremity soft exosuit which provide assistance during walking. In this study the Myosuit will be tested in the home and community setting in patients with incomplete spinal cord injury.","s":"Completed","tr":["Devices"],"o":["Leg Movement","Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05605912"},{"n":"NCT02600910","t":"Natural History of Shoulder Pathology in Manual Wheelchair Users","d":"Over 300,000 people in the United States have spinal cord injuries and many use manual wheelchairs for mobility. Most manual wheelchair users will develop shoulder injuries and pain that greatly affect quality of life and level of independence. Understanding when shoulder disease starts in manual wheelchair users and which daily activities contribute to the disease will provide necessary evidence for effective primary prevention methods to inhibit the development of further disability. Our…","s":"Active, not recruiting","tr":[],"o":["Arm Movement"],"st":["Minnesota","Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02600910","su":"https://scitrials.org/trial/NCT02600910"},{"n":"NCT07106060","t":"Near-Infrared Imaging of Motor Imagery Effects in Spinal Cord Injury","d":"The primary objective of this clinical trial is to investigate the efficacy of motor imagery-based brain-computer interface (MI-BCI) technology in improving motor function among patients with spinal cord injury (SCI), as well as its impact on cortical motor area function across varying states. To achieve this, the study will implement MI-BCI intervention in SCI patients, evaluate post-treatment motor function improvements, and assess changes in cortical motor area oxygen metabolism (via…","s":"Recruiting","tr":["Brain Machine Interface (BMI)"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07106060","su":"https://scitrials.org/trial/NCT07106060"},{"n":"NCT04422769","t":"Needs of Persons with Spinal Cord Injury (SCI)","d":"Persons with spinal cord injury (PwSCI) are at a greater risk for major health conditions and poorer health outcomes than persons without spinal cord injury (SCI). They often experience a great deal of health needs both on a physiological level as well as a psychosocial level. PwSCI frequently require supports and services to be able to live independently within the community. These services and supports are sometimes difficult to access within the community when the country is operating under…","s":"Completed","tr":["Observational"],"o":["Mental Health"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04422769"},{"n":"NCT03632005","t":"Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery","d":"The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.","s":"Unknown","tr":["Devices","Surgical Procedure"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03632005"},{"n":"NCT06351995","t":"Neostigmine and Glycopyrrolate by Iontophoresis","d":"To determine a lower effective dose of neostigmine to induce bowel evacuation by transcutaneous administration by iontophoresis.","s":"Active, not recruiting","tr":[],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06351995","su":"https://scitrials.org/trial/NCT06351995"},{"n":"NCT01714349","t":"Nerve Transfer After Spinal Cord Injuries","d":"Nerve Transfer surgery can provide improved hand function following cervical spinal cord injuries","s":"Completed","tr":["Surgical Procedure"],"o":["Hand Movement","Motor Function"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01714349"},{"n":"NCT04023591","t":"Nerve Transfer After Spinal Cord Injury- Multi-center","d":"Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a significant public health impact. Specific aim: Measure the efficacy of nerve transfer surgery in the treatment of patients with complete spinal cord injuries with no hand function. Optimize the efficiency of nerve transfer surgery by evaluating patient outcomes in relation to…","s":"Active, not recruiting","tr":[],"o":["Hand Movement"],"st":["California","Florida","Michigan","Missouri","Pennsylvania","Texas","Utah"],"co":["Canada","United States"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04023591","su":"https://scitrials.org/trial/NCT04023591"},{"n":"NCT01579604","t":"Nerve Transfer Reconstruction in the Tetraplegic Upper Extremity","d":"The cervical spine is most commonly injured, accounting for 53.4% of spinal injuries. More than 40% of all spinal injuries occur at either C4, C5 or C6 levels leading to variable loss of function in the upper extremities. Traditionally, patients sustaining a cervical spine injury were followed for 2 years to ensure that recovery had stabilized before offering upper extremity reconstruction. This type of reconstruction includes active muscle transfer, tendon transfer and joint fusion. Patients…","s":"Unknown","tr":[],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01579604","su":"https://scitrials.org/trial/NCT01579604"},{"n":"NCT05638191","t":"Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury","d":"The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function. The main questions it aims to answer are: * Does nerve transfer improve hand function in individuals with cervical spinal cord injury? * What factors are associated with functional improvement following nerve transfer? Researchers will compare functional outcomes at 24 months post-surgery…","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":4,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT05638191","su":"https://scitrials.org/trial/NCT05638191"},{"n":"NCT06288763","t":"Nerve Transfer to Improve Function in High Level Tetraplegia","d":"The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years…","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["California","Florida","Maryland","Michigan","Missouri","North Carolina","Pennsylvania","Texas","Utah"],"co":["Canada","United States"],"lc":10,"rlc":9,"cu":"https://clinicaltrials.gov/study/NCT06288763","su":"https://scitrials.org/trial/NCT06288763"},{"n":"NCT06596629","t":"Nerve Transfers for Restoration of Hand Function in Cervical Spinal Cord Injury: Effects and Influencing Factors","d":"The goal of this observational study is to learn about influencing factors on the clinical outcomes of nerve transfers used to restore hand function in patients with cervical spinal cord injury (CSCI). Specifically, the study focuses on the reinnervation of the posterior interosseus nerve (PIN) and the anterior interosseus nerve (AIN). The main questions it aims to answer are: 1. What is the duration after nerve transfer surgery until effect is achieved? 2. What is the influence of the…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Hand Movement"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06596629"},{"n":"NCT06541041","t":"Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury","d":"The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and/or pain outcomes for patients with cervical spinal cord injury undergoing standard of care nerve transfer surgery to improve hand function. The main hypotheses include: Hypothesis #1: Brief intraoperative electrical stimulation of the donor nerves will result in improved motor outcomes (hand function) compared…","s":"Recruiting","tr":[],"o":["Hand Movement"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06541041","su":"https://scitrials.org/trial/NCT06541041"},{"n":"NCT02861612","t":"Nerve Transfers to Restore Hand Function in Spinal Cord Injury","d":"This study seeks to evaluate the efficacy of nerve transfers in restoring hand function in patients with cervical spinal injuries.","s":"Withdrawn","tr":["Observational","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Missouri"],"co":["Canada","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02861612"},{"n":"NCT00055588","t":"Nervous System Function in Normal Volunteers During Cycling Training","d":"This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task. Healthy subjects 18 years of age and older who can cycle for 16 minutes may be eligible for this study. Candidates will be screened with a brief medical history and physical examination. Participants will be assigned to one of three groups: * Complex training: Cycling for 16 minutes at a constant speed of 60 rpm with frequent changes in pedal resistance. *…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Motor Function","Pain Management","Sensory Function","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00055588"},{"n":"NCT02768103","t":"Neural Adaptation After Tendon Transfer and Training in Tetraplegia","d":"The number of people in the United States who have survived SCI is estimated to be approximately 273,000 persons. Around 50% of the injuries are to the cervical spine resulting in tetraplegia. An important rehabilitation goal in this population is recovery of upper limb function, which could decrease medical costs and improve their quality of life. Re-establishing active grasp and pinch strength to the hand can be accomplished by surgeries that transfer the tendon of a strong muscle to restore…","s":"Completed","tr":["Rehabilitation","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02768103"},{"n":"NCT05354206","t":"Neural Facilitation of Movements in People With SCI","d":"Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).","s":"Terminated","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":[],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05354206"},{"n":"NCT06065384","t":"Neural Plasticity and Motor Recovery After Upper Extremity Motor Training in People With c-SCI","d":"After spinal cord injury (SCI), there is a disruption in neural circuits resulting in paralysis. There is not yet a cure for paralysis. In persons with Cervical SCI (pwC-SCI) recovery of arm-hand function is very important as it has a significant impact on the patients' level of independence and quality of life. Recovery is assumed to involve alterations in both central and peripheral motor systems. Motor training at an intensive dosage potentially provides a powerful stimulus for neurological…","s":"Recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Belgium","Netherlands"],"lc":4,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT06065384","su":"https://scitrials.org/trial/NCT06065384"},{"n":"NCT02326662","t":"Neural Stem Cell Transplantation in Traumatic Spinal Cord Injury","d":"This research investigates the use of autologous neural stem cells in patients with complete traumatic spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Russia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02326662","su":"https://scitrials.org/trial/NCT02326662"},{"n":"NCT06075056","t":"Neuro-navigated TMS for Chronic SCI Patients","d":"Can neuro-navigated Transcranial Magnetic Stimulation be used as an additional outcome measure to EM-SCI assessments in a Spinal cord injury trial? * Compare EM-SCI assessment with nTMS in ten chronic thoracic SCI patients * Compare EM-SCI assessment with nTMS in ten chronic cervical SCI patients","s":"Unknown","tr":["Observational","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06075056","su":"https://scitrials.org/trial/NCT06075056"},{"n":"NCT01297660","t":"Neuro-urological Outcome After Spinal Cord Injury","d":"Most patients with spinal cord injury suffer from bladder dysfunction which may - especially in the long-term - impair renal function. Improved treatment during the last decades improved life expectancy and quality of life. This study evaluates the bladder function in the long-term after spinal cord injury.","s":"Completed","tr":["Observational"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01297660"},{"n":"NCT02178917","t":"Neurofeedback for Treatment of Central Neuropathic Pain (CNP) in Sub-acute Spinal Cord Injury (SCI)","d":"Spinal Cord Injury (SCI) affects a person's ability to move and feel sensation in the body. SCI is also an indirect cause of a persistent pain, called Central Neuropathic Pain (CNP). This pain typically develops several months after the injury. In 30-40% of SCI patients, severe CNP affects their everyday living including sleep and mood. Many patients give up work, not because of the injury, but because of pain. Medical treatment of CNP is moderately effective and costly, both to the patient and…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Sensory Function","Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02178917"},{"n":"NCT04849676","t":"Neurofeedback to Improve Spasticity After Incomplete Spinal Cord Injury","d":"After incomplete spinal cord injury (iSCI), many people still have control over their upper and/or lower limbs, but secondary conditions such as spasticity impair the function they have left. Spasticity includes increased reflex response and muscle tone, and is often painful. In this study we want to test a rehabilitation therapy to reduce spasticity after iSCI and improve participants' control over their extremities. The study involves recording participants' brain signals (EEG) and displaying…","s":"Unknown","tr":["Rehabilitation"],"o":["Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04849676","su":"https://scitrials.org/trial/NCT04849676"},{"n":"NCT00947999","t":"Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)","d":"There has been little research on how chronic pain is related to brain activity. The purpose of this study is to learn more about pain and brain activity by finding any differences in brain activity among people who have moderate to severe chronic pain and a spinal cord injury, those who have a spinal cord injury but do not experience chronic pain, and people who have neither a spinal cord injury nor chronic pain (please note: subjects do not have to have pain to participate in this study). The…","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00947999"},{"n":"NCT00977041","t":"Neurofeedback Treatment of Pain in Persons With Spinal Cord Injury (SCI)","d":"A number of studies suggest that training to increase different types of brain waves is related to pain relief. The purpose of the second phase of this study is to see if neurofeedback training might help people with chronic pain control their pain better. The information from the study may help the investigators treat chronic pain better in the future.","s":"Completed","tr":[],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00977041"},{"n":"NCT01357980","t":"Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis","d":"The purpose of this study is to determine the efficacy and safety of a single dose of 750 U of Dysport compared to placebo for the improvement in the daily incontinence episode frequency for each administration mode in subjects suffering from neurogenic detrusor overactivity following spinal cord injury or multiple sclerosis.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Pain Management","Quality of Life"],"st":[],"co":["Czechia","France","Germany","Italy","Poland"],"lc":17,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01357980"},{"n":"NCT06815601","t":"Neuromodulation After Spinal Cord Injury to Improve Limb Function","d":"The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement. The goal of the study is to learn about how the brain, nerves, and muscles of the body are connected and perform everyday tasks. This may help us to develop ways to improve the hand functions of people with spinal cord injuries.","s":"Completed","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06815601","su":"https://scitrials.org/trial/NCT06815601"},{"n":"NCT05730049","t":"Neuromodulation as an Anti-inflammatory Treatment in SCI","d":"The goal of this single-blinded randomized, controlled trial is to assess the impact of 1-hour of active transcutaneous auricular vagus nerve stimulation (taVNS) vs sham taVNS on serum biomarkers of the inflammatory reflex and inflammation in individuals with spinal cord injury. The main question it aims to answer is: whether taVNS is a safe and effective anti-inflammatory intervention for individuals with SCI. Participants will perform a single 1-hour bout of the respective taVNS treatment…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05730049","su":"https://scitrials.org/trial/NCT05730049"},{"n":"NCT04238013","t":"Neuromodulation of Ankle Muscles in Persons With SCI","d":"The ability to voluntarily move the ankles is important for walking. After spinal cord injury (SCI), this ability is impaired because of changes in the communication between the brain, spinal cord, and body. Whole body vibration (WBV) is a treatment that increases voluntary muscle control and decreases uncontrollable muscle movement in people with SCI. The purpose of this study is to understand how WBV can impact ankle control and uncontrollable muscle movement.","s":"Terminated","tr":["Electrical Stimulation"],"o":["Mental Health","Motor Function","Spasticity","Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04238013"},{"n":"NCT04077346","t":"Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury","d":"Spinal cord injury (SCI) results in damage to the descending neural pathways and leads to the immediate dysfunction of multiple physiological systems below the level of injury. Like adults, children with SCI suffer from neuromuscular paralysis which results in the inability to sit, stand, and walk. Current therapeutic interventions largely aim to compensate for paralysis to achieve mobility based on the assumption that damage to the central nervous system is permanent and irreversible, e.g. use…","s":"Enrolling by invitation","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04077346","su":"https://scitrials.org/trial/NCT04077346"},{"n":"NCT04241250","t":"Neuromodulation Techniques After SCI","d":"Spinal cord injury (SCI) leads to several health-related consequences often linked to reduced levels of physical activity. Direct stimulation of the spinal cord, either through implanted devices or surface stimulation, has been combined with intense physical therapy assisted treadmill walking to facilitate independent standing and stepping. These current methods require 3-4 highly skilled therapists and may not be feasible in all rehabilitation settings, especially when considering the growing…","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Exoskeleton","Rehabilitation"],"o":["Walking Function"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04241250"},{"n":"NCT07433959","t":"Neuromodulation to Improve Grasping Function After SCI","d":"The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07433959","su":"https://scitrials.org/trial/NCT07433959"},{"n":"NCT04883463","t":"Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury","d":"This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach. Participants may qualify for the study if they are male or female 18-75 years old, are at least 1 year after original injury, have injury at C2 to C7 level, and dependent on mechanical ventilation to help them breathe. Additionally, they need to be able to attend…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Breathing Function"],"st":["California"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT04883463","su":"https://scitrials.org/trial/NCT04883463"},{"n":"NCT06274021","t":"Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury","d":"People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly. The investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Spasticity"],"st":["Mississippi"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06274021","su":"https://scitrials.org/trial/NCT06274021"},{"n":"NCT06272279","t":"Neuromodulation With Spinal Stimulation Methods","d":"This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled. A variety of stimulation parameters and outcome measures will be assessed.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06272279","su":"https://scitrials.org/trial/NCT06272279"},{"n":"NCT07099911","t":"Neuromuscular Electrical Stimulation and Glucose Control in Spinal Cord Injury","d":"Overall aim: To identify the impact and acceptability of a novel method of neuromuscular electrical stimulation (NMES) for improving glucose control using a dual stable isotope tracer OGTT in individuals with spinal cord injury (SCI). Objective 1: 1. To establish the extent to which an acute bout of NMES improves health-related measures of glucose control, compared to a SHAM control trial. 2. To identify the relative magnitude of effect, compared to non-injured control participants (CON)…","s":"Recruiting","tr":["Electrical Stimulation","Nutrition"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07099911","su":"https://scitrials.org/trial/NCT07099911"},{"n":"NCT05492188","t":"Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI","d":"The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).","s":"Recruiting","tr":[],"o":["Pain Management"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05492188","su":"https://scitrials.org/trial/NCT05492188"},{"n":"NCT01579500","t":"Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients","d":"The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01579500"},{"n":"NCT02446210","t":"Neuroplasticity After Spinal Cord Injury","d":"The long-term goal is to acquire scientific knowledge that can be used to develop mechanistic-driven intervention strategies aiming at restoring upper and lower-limb motor function in individuals with cervical or thoracic spinal cord injury (SCI). The proposed project will examine cortical, corticospinal, and spinal contribution to bilateral hand and arm muscle activity during bilateral movements and spinal contributions to lower limb muscle activity. By comparing changes in different sites…","s":"Unknown","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02446210","su":"https://scitrials.org/trial/NCT02446210"},{"n":"NCT02688049","t":"NeuroRegen Scaffold™ Combined With Stem Cells for Chronic Spinal Cord Injury Repair","d":"The purpose of this study is to assess the efficacy and safety of mesenchymal stem cells or neural stem cells combined with NeuroRegen scaffold transplantation in patients with spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02688049","su":"https://scitrials.org/trial/NCT02688049"},{"n":"NCT02688062","t":"NeuroRegen Scaffold™ With Bone Marrow Mononuclear Cells Transplantation vs. Intradural Decompression and Adhesiolysis in SCI","d":"The purpose of this study is to investigate the efficacy and safety of NeuroRegen Scaffold with bone marrow mononuclear cells (BMMCs) on neurological recovery following chronic and complete spinal cord injury, compared to the treatment of surgical intradural decompression and adhesiolysis only.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02688062","su":"https://scitrials.org/trial/NCT02688062"},{"n":"NCT02352077","t":"NeuroRegen Scaffold™ With Stem Cells for Chronic Spinal Cord Injury Repair","d":"The purpose of this study is to assess the safety and efficacy of NeuroRegen scaffold with bone marrow mononuclear cells (BMMCs) or mesenchymal stem cells (MSCs) in patients with chronic spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02352077","su":"https://scitrials.org/trial/NCT02352077"},{"n":"NCT07739043","t":"NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI","d":"The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume calculated using M = 0.167 mL/kg BW. Study details include: The overall study duration will be up to three years. The primary endpoint will be assessed at 6 months following investigational product administration. An additional secondary endpoint will be assessed at 12…","s":"Not yet recruiting","tr":["Drugs","Safety","Stem Cells"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07739043"},{"n":"NCT05756894","t":"Neurostimulation for Respiratory Function After Spinal Cord Injury","d":"The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in respiratory function and recovery using stimulation and respiratory exercise training in spinal cord-injured individuals. Participants will complete a maximum of 55 study visits. They will be asked to complete about 40 treatment sessions which include multiple stimulation…","s":"Recruiting","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Breathing Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05756894","su":"https://scitrials.org/trial/NCT05756894"},{"n":"NCT05465486","t":"NeuroSuitUp: Neurorehabilitation Through Synergistic Man-machine Interfaces","d":"NeuroSuitUp is a multidisciplinary neurophysiological \\& neural rehabilitation engineering project, developed by the Lab of Medical Physics \\& Digital Innovation, School of Medicine, Faculty of Health Science Aristotle University of Thessaloniki and supported by a Neurosurgical Department. This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme \"Human Resources Development, Education and Lifelong Learning 2014- 2020\" in the…","s":"Unknown","tr":["Brain Stimulation"],"o":["Arm Movement"],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05465486","su":"https://scitrials.org/trial/NCT05465486"},{"n":"NCT04474106","t":"NEUROwave - Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury","d":"It has been hypothesized that there are two mechanisms of acute traumatic spinal cord injury (SCI): the primary mechanical damage and the secondary injury due to additional pathological processes initiated by the primary injury. Neurological damage due to laceration, contusion, distraction or compression of the spinal cord is called ''primary injury''. This mechanical injury leads to a cascade of biochemical and pathological changes, described as ''secondary injury'', which occurs minutes to…","s":"Recruiting","tr":["Safety"],"o":[],"st":[],"co":["Austria"],"lc":15,"rlc":8,"cu":"https://clinicaltrials.gov/study/NCT04474106","su":"https://scitrials.org/trial/NCT04474106"},{"n":"NCT06831240","t":"New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)","d":"The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness of a new design.","s":"Not yet recruiting","tr":["Devices","Observational"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06831240"},{"n":"NCT06817577","t":"NG004 in Spinal Cord Injury Patients","d":"This is the FIH, multicenter, open-label, sequential, multiple ascending dose trial of NG004 in patients with acute incomplete cervical SCI. The trial will evaluate the safety, tolerability, and PK of 4 dose regimens of NG004, and will evaluate the maximum tolerated dose of NG004. The trial consists of Part A (the dose escalation) and Part B (the PK-confirmation at 2 dose levels from Part A).","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Germany","Switzerland"],"lc":6,"rlc":6,"cu":"https://clinicaltrials.gov/study/NCT06817577","su":"https://scitrials.org/trial/NCT06817577"},{"n":"NCT06247904","t":"NIBS Therapy in Subacute Spinal Cord Injury","d":"No accepted clinical therapies exist for repair of motor pathways following spinal cord injury (SCI) in humans, leaving permanent disability and devastating personal and socioeconomic cost. A robust neural repair strategy has been demonstrated in preclinical studies, that is ready for translation to recovery of hand and arm function in human SCI, comprising daily transcranial magnetic stimulation treatment at the inpatient rehabilitation facility. This study will establish clinical effect size…","s":"Enrolling by invitation","tr":["Brain Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06247904","su":"https://scitrials.org/trial/NCT06247904"},{"n":"NCT07541612","t":"NIRS MONITORING OF SPINAL CORD ISCHEMIA IN AORTIC SURGERY","d":"This prospective observational study aims to evaluate the feasibility and clinical utility of near-infrared spectroscopy (NIRS) monitoring applied to paraspinal muscles as a surrogate marker of spinal cord perfusion in patients undergoing major noncardiac surgery. Spinal cord ischemia represents a rare but devastating complication, often difficult to detect in real time. NIRS provides a non-invasive, continuous monitoring of regional tissue oxygen saturation (rSO₂), potentially reflecting…","s":"Recruiting","tr":["Devices","Observational","Surgical Procedure"],"o":["Blood Pressure"],"st":[],"co":["Italy"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07541612"},{"n":"NCT03935321","t":"NISCI - Nogo Inhibition in Spinal Cord Injury","d":"The purpose of the NISCI trial is to test if an antibody therapy can improve movement and quality of life of tetraplegic patients. A previous trial showed this treatment is safe and well accepted. This is a placebo controlled, randomized, double blind, multicenter, multinational study to assess the safety, tolerability, feasibility and preliminary efficacy of early (within 4-28 days post injury) initiation of treatment with repeated bolus injections of NG-101 in cervical acute SCI patients. The…","s":"Completed","tr":["Drugs"],"o":["Arm Movement","Bladder Function","Hand Movement","Motor Function","Quality of Life","Sensory Function","Walking Function"],"st":[],"co":["Czechia","Germany","Spain","Switzerland"],"lc":13,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03935321"},{"n":"NCT05635851","t":"NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI","d":"This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.","s":"Not yet recruiting","tr":[],"o":["Bowel Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05635851","su":"https://scitrials.org/trial/NCT05635851"},{"n":"NCT05644522","t":"Nomad P-KAFO Study","d":"The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk. The main questions it aims to answer are to quantify the effectiveness of the Nomad in improving mobility, balance, frequency of falls, and quality of life in individuals with lower-extremity impairments compared to their own brace, over three months of daily home and community use. Participants will: *…","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05644522","su":"https://scitrials.org/trial/NCT05644522"},{"n":"NCT02324322","t":"Non-Ambulatory SCI Walk Using a Robotic Exoskeleton: Effect on Bone and Muscle","d":"The purpose of this research study is to evaluate an exoskeleton device and mobility skills in the device.","s":"Unknown","tr":["Exoskeleton"],"o":["Bone Strength"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02324322","su":"https://scitrials.org/trial/NCT02324322"},{"n":"NCT05183152","t":"Non-invasive BCI-controlled Assistive Devices","d":"Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement without actually performing it. Brain-computer interfaces (BCIs) can decode SMRs to control assistive devices and promote functional recovery. Despite rapid advancements in non-invasive BCI systems…","s":"Recruiting","tr":["Brain Machine Interface (BMI)","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)","Rehabilitation","Transcutaneous Stimulation"],"o":["Motor Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05183152"},{"n":"NCT02711319","t":"Non-invasive Brain Stimulation for Gait Improvement in Patients With Spinal Cord Injury","d":"to optimize the functional outcome in early phase of gait rehabilitation in subacute incomplete SCI patients using rTMS as an additional treatment to physical therapy (e.g. to gait training in Lokomat®). Using this add-on therapeutic strategy, we expected larger improvement of gait function than with physical therapy alone.","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Motor Function","Spasticity","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02711319"},{"n":"NCT05975606","t":"Non-invasive Brain Stimulation Paired With FES Cycling Post SCI","d":"This project is randomized controlled trial which will explore the effect of pairing repetitive Transcranial Magnetic Stimulation (rTMS) with Functional Electrical Stimulation (FES) Cycling on lower extremity function in people with incomplete spinal cord injury and compare the effects to each one of these interventions alone.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05975606","su":"https://scitrials.org/trial/NCT05975606"},{"n":"NCT03414424","t":"Non-invasive Cervical Electrical Stimulation for SCI","d":"Most spinal cord injuries (SCI) are anatomically incomplete - some nerve circuits remain intact, even if the individual cannot feel or control them. Activating spared nerve circuits may improve functional recovery. With this goal, the Investigators have developed a form of electrical stimulation over the cervical spinal cord that can activate muscles in both hands simultaneously and comfortably. This technique, called cervical electrical stimulation (CES), works at the skin surface - no surgery…","s":"Completed","tr":["Electrical Stimulation","Surgical Procedure","Transcranial Magnetic Stimulation (TMS)"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03414424"},{"n":"NCT05994846","t":"Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal","d":"The objectives of this study are to (1) determine the effects of neuromodulation techniques on mobility in persons with chronic SCI, as measured by subjective and objective measures, and (2) to determine the optimal combination of techniques that modify mobility and movement in an individual. The neuromodulation techniques explored will be methods of electromagnetic stimulation - that is, electrical stimulation and magnetic stimulation.","s":"Suspended","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Regeneration"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05994846","su":"https://scitrials.org/trial/NCT05994846"},{"n":"NCT00001216","t":"Non-Invasive Electrical Stimulation of the Human Brain","d":"This study is designed to allow researchers to use transelectrical stimulation to explore the function of the human nervous system and improve diagnosis of neurological disorders. Transcranial electrical stimulation is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. Electrical stimulation involves placing electrodes on the scalp or skin and passing an electrical current between them. When this is done, an electrical field is…","s":"Completed","tr":["Electrical Stimulation","Observational"],"o":[],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00001216"},{"n":"NCT07135583","t":"Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury","d":"Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing. As a result, people with SCI often face breathing problems, a higher risk of lung infections, and even early death. While breathing exercises can help strengthen these muscles, they often aren't intense enough to make a big difference, especially in people with long-term injuries. This research project is exploring a…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Breathing Function"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07135583","su":"https://scitrials.org/trial/NCT07135583"},{"n":"NCT03877432","t":"Non-invasive Nerve Stimulation for Inhibition of Bladder Incontinence in Spinal Cord Injured Subjects.","d":"Investigators will test S2-S4 dermatome stimulation with spinal cord injury (SCI) individuals using intermittent catheterization to estimate the clinical impact on bladder capacity and continence. For individuals with SCI using intermittent catheterization, investigators hypothesize that dermatome stimulation will decrease bladder spasm frequency and intensity, and reduce bladder incontinence chronically. The goal of this study is to provide objective evidence for the assertion that dermatome…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03877432","su":"https://scitrials.org/trial/NCT03877432"},{"n":"NCT06903416","t":"Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial","d":"This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life. It will compare transcutaneous spinal cord stimulation and paired corticospinal-motoneuronal stimulation, both combined with rehabilitation. Using a crossover design, participants will receive each therapy for two months, with a one-month washout period in between. Safety, effectiveness, and…","s":"Recruiting","tr":["Electrical Stimulation","Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06903416","su":"https://scitrials.org/trial/NCT06903416"},{"n":"NCT03998527","t":"Non-Invasive Spinal Cord Stimulation After Injury","d":"The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a combination of arm training and stimulation, or a combination of trunk training and stimulation. The respiratory, arm, and trunk training combined with the spinal stimulation interventions are being used to activate the spinal cord below the level of injury…","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Breathing Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03998527","su":"https://scitrials.org/trial/NCT03998527"},{"n":"NCT06260735","t":"Non-invasive Spinal Cord Stimulation After Spinal Cord Injury","d":"Spinal cord injury (SCI) is a central nervous system injury that often leads to motor dysfunction. Non-invasive electrical stimulation of the spinal cord has been recognized as a potential method of reactivating lost spinal neural networks to improve motor recovery and exercise response after SCI. Trans-spinal electrical stimulation (ts-ES) has been found to increase functional gains in people after SCI when applied in combination with other motor training protocols. This project aims to…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06260735","su":"https://scitrials.org/trial/NCT06260735"},{"n":"NCT07504055","t":"Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury","d":"The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury. The main questions it aims to answer are: * Can site specific spinal cord stimulation enhance blood pressure regulation? * Does this stimulation affect enzymes responsible for blood pressure regulation? Researchers will stimulate different sites of spinal cord and compare to see if site-specific stimulation provide…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["Kentucky"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07504055","su":"https://scitrials.org/trial/NCT07504055"},{"n":"NCT05369520","t":"Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury","d":"This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05369520","su":"https://scitrials.org/trial/NCT05369520"},{"n":"NCT05091463","t":"Non-invasive Spinal Stimulation as an Adjuvant Therapy for Trunk Control After Pediatric SCI","d":"The overall purpose of this study is to test the efficacy of multi-modal training combining activity-based locomotor training and transcutaneous spinal stimulation (ABLT+scTS) to improve sitting posture and trunk control in children with a chronic spinal cord injury. The investigators will recruit 12 participants, ages 3-12 with chronic, acquired SCI, T10 and above and non-ambulatory. The participants in this study will be novices to scTS and AB-LT.","s":"Completed","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05091463","su":"https://scitrials.org/trial/NCT05091463"},{"n":"NCT03592173","t":"Non-Invasive Stimulation for Improving Motor Function","d":"The purpose of this study is to determine if spinal excitability is increased with a Spinal Associative Stimulation (SAS) protocol, and to determine the functional consequences of this technique on motor recovery.","s":"Unknown","tr":[],"o":["Regeneration"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03592173","su":"https://scitrials.org/trial/NCT03592173"},{"n":"NCT04977284","t":"Noninvasive Neuroprosthesis for Autonomic Recovery After SCI","d":"This research study is being conducted to help explore the effects of non-invasive (non-surgical) spinal cord stimulation via sticky electrodes over the skin (transcutaneous spinal cord stimulation; TCSCS) on bowel, bladder and sexual function following spinal cord injury. Our primary aim is to determine the specific location and timing of TCSCS at various spinal cord levels in order to target bladder and bowel control (Study 1 and 2), and to assess the safety and effectiveness of TCSCS during…","s":"Unknown","tr":[],"o":["Bladder Function","Bowel Function","Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04977284","su":"https://scitrials.org/trial/NCT04977284"},{"n":"NCT06587841","t":"Noninvasive Spinal Cord Stimulation for Early SCI","d":"The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as well as spasticity in individuals with subacute and chronic SCI (time since injury 3-6 months) and the impact on quality of life. The study will be conducted at two sites; site 1 in Canada and site 2 in the Ukraine. Up to 60 subjects will be enrolled; 10 adults at the…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06587841","su":"https://scitrials.org/trial/NCT06587841"},{"n":"NCT06489106","t":"Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury","d":"The main goal of this pilot study is to find the best ways to use transcutaneous spinal cord stimulation (scTS) to improve hand function in children with spinal cord injuries (SCI). The investigators will start by exploring the best places and strengths for applying scTS on the neck, the added benefits of applying scTS on the lower back (T11-T12), and comparing the effects of using activity based upper extremity training (a control treatment) alone versus combining it with scTS to help children…","s":"Enrolling by invitation","tr":["Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06489106","su":"https://scitrials.org/trial/NCT06489106"},{"n":"NCT01093014","t":"Novel Intervention to Influence Muscle Plasticity in Veterans","d":"The loss of muscle contraction (paralysis) removes an important stimulus for maintenance of overall health for individuals with complete spinal cord injury (SCI). Increased protein catabolism (atrophy) limits important stresses to the skeletal system. Bone loss doubles the risk of fracture and contributes to increased mortality in Veterans with SCI. Metabolic syndrome and diabetes lead to heart disease in Veterans with SCI at higher rates than the general population. Exercise methods to sustain…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation"],"o":["Blood Pressure","Bone Strength","Plasticity"],"st":["Iowa"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01093014"},{"n":"NCT02538809","t":"Novel mRNA-based Urine Test for Bladder Cancer in Spinal Cord Injury Individuals","d":"Bladder cancer is a well-recognized complication in spinal cord injury (SCI) individuals. The observed incidence rates in SCI individuals are considerably higher compared to the general population. Bladder cancer in SCI individuals tends to present at an earlier age compared to the general population. Furthermore, bladder cancer in SCI individuals is more commonly invasive and at a more advanced stage at the time of diagnosis compared to bladder cancer in the general population. Individuals…","s":"Terminated","tr":["Devices","Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02538809"},{"n":"NCT06438471","t":"Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury","d":"The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury. The main question it aims to answer is whether EC5026 is safe and well tolerated in SCI patients with neuropathic pain. In addition, this trial will also study the effects of EC5026 on pain. Researchers will compare EC5026 to placebo. Participants will be asked to: * Take…","s":"Recruiting","tr":[],"o":["Pain Management"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06438471","su":"https://scitrials.org/trial/NCT06438471"},{"n":"NCT04798378","t":"NuroSleeve Powered Brace & Stimulation System to Restore Arm Function","d":"The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one arm sufficient to perform daily activities. This study could lead to the development of a product that could allow people with arm weakness or arm paralysis to use the NuroSleeve and similar devices to improve arm health and independent function.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Arm Movement"],"st":["Delaware","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04798378","su":"https://scitrials.org/trial/NCT04798378"},{"n":"NCT07179588","t":"Nutrition and Pain Study","d":"The purpose of this research is to assess the effectiveness of a nutrition intervention on diet quality in managing pain in individuals with spinal cord injury (SCI).","s":"Active, not recruiting","tr":["Nutrition"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07179588","su":"https://scitrials.org/trial/NCT07179588"},{"n":"NCT02368405","t":"Nutrition Education for Cardiovascular Disease Prevention in Spinal Cord Injury","d":"This is a randomized controlled trial to study a nutrition education intervention in individuals with spinal cord injuries both in the acute rehabilitation setting (n = 100) and the community setting (n = 100). Participants in the treatment group will receive six interactive nutrition lectures based upon a successful program that has been used in older adults titled \"Eat Smart, Stay Well\". The goals of intervention are to improve whole-grain, fruit and vegetable, and low-fat dairy intake and…","s":"Completed","tr":["Nutrition","Rehabilitation"],"o":["Blood Pressure"],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02368405"},{"n":"NCT05953597","t":"Nutrition Education Program in Spinal Cord Injury (SCI)","d":"The purpose of this research is to assess the effectiveness of a nutrition education program in increasing nutrition knowledge and improving health-related biomarkers in individuals with spinal cord injury (SCI).","s":"Completed","tr":["Nutrition"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05953597"},{"n":"NCT05965700","t":"NVG-291 in Spinal Cord Injury Subjects","d":"A Randomized, Double-Blind, Placebo-Controlled Phase 1b/2a Study of NVG-291 in Spinal Cord Injury Subjects","s":"Completed","tr":["Drugs","Safety"],"o":["Arm Movement","Hand Movement","Leg Movement","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05965700"},{"n":"NCT03793595","t":"O2 Consumption and Heart Rate Response to Battle Rope Exercise Protocol Versus UE Arm Bike Test in Adults With SCI","d":"The purpose of this study is to compare energy expenditure and metabolic outcomes of a novel seated battle rope protocol to seated maximal ramped upper extremity ergometry protocol in subjects with spinal cord injury.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03793595","su":"https://scitrials.org/trial/NCT03793595"},{"n":"NCT01467817","t":"Obesity/Overweight in Persons With Early and Chronic Spinal Cord Injury (SCI)","d":"The purpose of this study is to determine how exercise and nutritional guidance and supplementation affects your physical fitness, risk for heart disease, your body's ability to burn fat, and your opinions about your health.","s":"Completed","tr":["Nutrition"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01467817"},{"n":"NCT04962165","t":"Obstructive Sleep Apnea Management in People With Spinal Cord Injury","d":"The prevalence of obstructive sleep apnea (OSA) is a significantly higher in people after spinal cord injury (SCI) than in the general population. As a positive pressure therapy (CPAP) is often poorly tolerated, a mandibular advancement device (MAD) can be used for the treatment of OSA. The purpose of this study is to determine the efficacy of MAD in people with SCI and to verify their adherence to the therapy.","s":"Unknown","tr":[],"o":["Breathing Function"],"st":[],"co":["Czechia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04962165","su":"https://scitrials.org/trial/NCT04962165"},{"n":"NCT07596563","t":"Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury","d":"This is a randomised, blinded and controlled Phase I trial to measure the safety, feasibility and efficacy of a combined cell transplantation and intensive rehabilitation intervention to treat spinal cord injury. The trial aims to examine whether transplantation of olfactory cell nerve bridges combined with intensive rehabilitation is safe and feasible for people living with chronic spinal cord injury in Australia, and whether the intervention improves structural integrity of the spinal cord…","s":"Not yet recruiting","tr":["Rehabilitation","Stem Cells"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07596563","su":"https://scitrials.org/trial/NCT07596563"},{"n":"NCT01311375","t":"Omega 3 in Intervention Spinal Cord Injured People","d":"The objective of this study is to evaluate the effect of omega 3 fatty acid on neurological recovery, lipid profile and Antioxidant system in patients with spinal cord injury. One hundred spinal cord injured patients who come to clinic of spinal injury repair research center selected. Then the patients will receive two supplements capsules of omega 3 (600 mg) in the intervention group and placebo in the control group. Primary outcome measures are professionals evaluation of neurological…","s":"Completed","tr":[],"o":["Bone Strength","Motor Function","Quality of Life"],"st":[],"co":["Iran"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01311375"},{"n":"NCT01896037","t":"Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels","d":"People with a spinal cord injury (SCI) characteristically have low levels of high-density lipoprotein-cholesterol (HDL-c; \"good cholesterol\") and high levels of low-density lipoprotein-cholesterol (LDL-c; \"bad cholesterol\"), and are at a higher risk of developing cardiovascular health problems, such as heart disease, heart attack and stroke, than the able-bodied population. A common way for able-bodied people to improve their lipid profile is through exercise; however, SCI people, especially…","s":"Completed","tr":["Nutrition"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01896037"},{"n":"NCT01050114","t":"OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER","d":"Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine. A patient who has a spinal cord injury (SCI) often suffers from an overactive bladder which often leads to urinary incontinence (UI - an unwanted leakage of urine). OnaBoNT-A bladder injections have been studied in clinical research trials. The results have shown an improvement in urinary symptoms by reducing how often urine leakage…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01050114","su":"https://scitrials.org/trial/NCT01050114"},{"n":"NCT03292315","t":"Once Weekly GLP-1 in Persons With Spinal Cord Injury","d":"Chronic spinal cord injury (SCI) results in adverse soft tissue body composition changes and an extremely sedentary lifestyle. These abrupt changes often lead to a high prevalence of cardiometabolic diseases, such as impaired glucose tolerance/diabetes mellitus and dyslipidemia, conditions which predispose those with SCI to an increased risk for cardiovascular disease compared to the general population. Due to paralysis and wheel chair dependence, maintaining an adequate level of physical…","s":"Completed","tr":["Drugs","Nutrition"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03292315"},{"n":"NCT05491525","t":"Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC","d":"The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC","s":"Recruiting","tr":["Drugs"],"o":["Bladder Function"],"st":["Arkansas","California","Colorado","Florida","Kansas","Louisiana","New York","North Carolina","Oklahoma","Oregon"],"co":["Belgium","Canada","Croatia","Denmark","Georgia","Jordan","Latvia","Lithuania","Malaysia","Philippines","Poland","Romania","Serbia","Slovakia","Turkey (Türkiye)","United States"],"lc":38,"rlc":32,"cu":"https://clinicaltrials.gov/study/NCT05491525"},{"n":"NCT05094362","t":"Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning","d":"The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure. The study involves approximately 45 visits with a total study duration of about 6 months.","s":"Recruiting","tr":["Rehabilitation"],"o":["Spasticity"],"st":["South Carolina"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05094362","su":"https://scitrials.org/trial/NCT05094362"},{"n":"NCT04811235","t":"Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial","d":"The study involves the 'first-in-human' evaluation of a novel optical sensor which uses near-infrared spectroscopy (NIRS) technology to assess oxygenation and hemodynamics of the injured spinal cord. The NIRS sensor is laid on top of the dura, at the site of the SCI, and emits near-infrared light signals into the cord to measure tissue oxygenation and tissue hemodynamics in real-time. Our testing of this novel NIRS sensor in patients with acute SCI represents the first step in translating this…","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04811235","su":"https://scitrials.org/trial/NCT04811235"},{"n":"NCT01485458","t":"Optimal Treatment for Spinal Cord Injury Associated With Cervical Canal Stenosis (OSCIS) Study","d":"Controversy exists regarding the optimal management of acute traumatic cervical spinal cord injury (SCI), especially those without bone injury. Although surgical decompression is often performed in SCI patients with cervical canal stenosis, efficacy and timing of surgery continues to be a subject of intense debate. In this randomized controlled trial, the investigators compare two strategies: early surgery within 24 hours after admission and delayed surgery following at least 2 weeks of…","s":"Completed","tr":["Surgical Procedure"],"o":["Motor Function","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Japan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01485458"},{"n":"NCT07099625","t":"Optimization of Adaptive Rowing Seating","d":"Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities. These activity-based communities are medicine free treatment systems enhancing Veterans' health from a holistic perspective. This approach to Veteran healthcare is critical as studies indicate Veterans not only have 56% higher perceived social isolation but are also 1.5x more susceptible to suicide than the general public. It is imperative to…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":[],"st":["Minnesota","Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07099625","su":"https://scitrials.org/trial/NCT07099625"},{"n":"NCT06318832","t":"Optimizing a Wellbeing Program for Care-partners of Those With SCI","d":"Spinal cord injuries (SCI) have a devastating effect not only on individuals incurring the life changing event, but also on those who are involved in their care. Family care-partners of those with SCI (fcSCI) may experience significant negative effects including impaired mental health, high levels of burden, poor adjustment to role, decreased quality of life and strain on relationships. Cognitive behaviour therapy (CBT) is an evidence-based treatment strategy that helps individuals recognize…","s":"Unknown","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06318832"},{"n":"NCT04468919","t":"Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit","d":"This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases. Researchers will optimize \\& adapt BCI signal acquisition, signal processing, natural language processing, \\& clinical implementation. BCI-FIT relies on active inference and transfer learning to customize a completely adaptive intent estimation classifier to each user's multi-modality signals simultaneously. 3 specific aims are: 1. develop \\&…","s":"Completed","tr":["Brain Machine Interface (BMI)","Nutrition"],"o":[],"st":["Oregon"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04468919"},{"n":"NCT04400747","t":"Oral Colecalciferol Treatment in Spinal Cord Lesion","d":"Low vitamin D is frequently seen in patients with spinal cord injury (SCI) in acute and chronic periods. Among its causes are insufficient sun exposure, limited oral intake, obesity, the effect of the drugs used on the absorption of vitamin D, kidney and liver diseases. If we consider patients with spinal cord injuries in Turkey, it is difficult to get involved in the society, low exposure to the sun, lack of necessary health controls and immobility brings extra risk factors for the low vitamin…","s":"Completed","tr":["Drugs","Nutrition","Rehabilitation"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04400747"},{"n":"NCT00108043","t":"Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia","d":"Objective: The objective of this research is to undertake a safety and viability study of FES-evoked stepping in individuals with paraplegia. The rationale for this objective is based upon the need to clarify whether physiological limitations, especially orthostatic intolerance, limit functional mobility outcomes. The cardiovascular, autonomic, and muscle metabolic factors governing orthostatic tolerance during skin-surface FES stepping will be investigated, since this functional task forms the…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Blood Pressure","Walking Function"],"st":[],"co":["Australia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00108043"},{"n":"NCT04210063","t":"Orthostatic, Respiratory, Balance-Intervention","d":"The purpose of this study is to help understand how training breathing muscles will impact balance, blood pressure, and quality of life of participants with spinal cord injury.","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Quality of Life","Trunk Control"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04210063"},{"n":"NCT04367571","t":"Osteopathic Manipulative Treatments and Neurogenic Bowel Dysfunction in Patients With Spinal Cord Injuries.","d":"Studies based on the relationship between Osteopathic Manipulative Treatment (OMT) and the gastrointestinal system have been conducted in patients with constipation with Irritable Bowel Syndrome (IBS), and in children with infantile cerebral palsy. For IBS patients, OMT can facilitate visceral vascularization and restore the physiological elasticity and motility of the viscera, and of the peritoneal structures around the viscera. The study also focused on the effects of OMT on women and…","s":"Completed","tr":[],"o":["Blood Pressure","Bowel Function","Quality of Life"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04367571"},{"n":"NCT03307161","t":"Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia","d":"This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.","s":"Completed","tr":[],"o":["Blood Pressure","Trunk Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03307161"},{"n":"NCT07725081","t":"Osteoporosis Awareness in Chronic Spinal Cord Injury","d":"Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures. Despite this elevated risk, awareness of osteoporosis among individuals living with SCI is not well understood. This cross-sectional observational study assessed the level of osteoporosis awareness in adults with chronic traumatic SCI and examined which demographic, injury-related, and healthcare-related factors were independently associated with awareness…","s":"Completed","tr":["Observational"],"o":["Bone Strength"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07725081"},{"n":"NCT04900896","t":"Outcome Measures Study on an Adult Myoelectric Elbow-Wrist-Hand Orthosis","d":"The objective of this study is to evaluate the therapeutic and functional gains of a myoelectric elbow-wrist-hand orthosis for adult individuals with upper limb impairments using repeated measures studies that combines both gross motion and quantitative function outcome measures.","s":"Unknown","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":["Massachusetts","Ohio","Washington"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04900896","su":"https://scitrials.org/trial/NCT04900896"},{"n":"NCT03624218","t":"Outcomes After Spinal Cord Injury (OASIS)","d":"The study evaluates the effectiveness of Prolonged Exposure Therapy on a population of individuals with spinal cord injuries. Participants will be randomly assigned to either a treatment as usual or Prolonged Exposure therapy group.","s":"Completed","tr":["Drugs"],"o":["Mental Health","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03624218"},{"n":"NCT05473689","t":"Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)","d":"This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe sleep-related breathing disorders (SRBDs) among adults at 6 weeks after SCI; (ii) delayed CPAP therapy in the management of moderate-to-severe SRBDs among adults at 22 weeks after SCI; and (iii) no treatment as they either have mild or no SRBD.","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05473689","su":"https://scitrials.org/trial/NCT05473689"},{"n":"NCT03989752","t":"Overground Walking Program With Robotic Exoskeleton in Long-term Manual Wheelchair Users With Spinal Cord Injury","d":"Many individuals with a spinal cord injury (SCI) use a wheelchair as their primary mode of locomotion. The prolonged non-active sitting time associated to this mode of locomotion contributes to development or worsening of numerous adverse health effects affecting musculoskeletal, endocrino-metabolic and cardiorespiratory health. To counter this vicious circle, engaging in a walking program with a wearable robotic exoskeleton (WRE) is a promising physical activity intervention. This study aims…","s":"Terminated","tr":["Exoskeleton"],"o":["Bone Strength","Leg Movement","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03989752"},{"n":"NCT05391308","t":"Overnight Upper Airway Infiltration in Spinal Cord Injury","d":"Obstructive Sleep Apnea (OSA), a common disorder resulting from repetitive pharyngeal collapse during sleep, is multifactorial. Usually, OSA is considered primarily a problem of upper airway anatomy, with the craniofacial structure or neck fat decreasing the size of the pharyngeal airway lumen. Obesity, male sex and genetics are well established pathogenic factors. In the last decade rostral fluid displacement (fluid shift) to explain the pathogenesis of upper airway collapsibility has been…","s":"Completed","tr":["Intermittent Hypoxia","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05391308"},{"n":"NCT00101361","t":"Oxandrolone to Heal Pressure Ulcers","d":"This study is designed to determine whether the use of oxandrolone, an anabolic steroid, can heal pressure ulcers in persons with spinal cord injury (SCI). In a Feasibility Study, three VA SCI Units will screen and randomize patients into treatment with oxandrolone or with placebo. Eleven other sites will screen patients to determine eligibility but will not treat patients with the agent. Following the Feasibility Study, all sites will participate in a blinded, randomized treatment study. A…","s":"Terminated","tr":["Drugs"],"o":["Pressure Sores"],"st":["California","Florida","Georgia","Illinois","Massachusetts","Missouri","New York","Ohio","Texas","Virginia","Wisconsin"],"co":["Puerto Rico","United States"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00101361"},{"n":"NCT00860951","t":"P300 Brain Computer Interface Keyboard to Operate Assistive Technology","d":"The purpose of this research is to develop tools enable people who are paralyzed to operate technology and access computers. These tools are called brain computer interfaces (BCIs). BCIs would let a person use brain signals to operate technology.","s":"Completed","tr":["Brain Machine Interface (BMI)","Devices"],"o":[],"st":["Michigan","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00860951"},{"n":"NCT05421260","t":"Paediatric Spinal Cord Injury and Long-term Social Outcomes.","d":"To provide the overall quality of life (QOL), activity and participation values for adults with paediatric onset spinal cord injury (SCI), stratified by injury level, neurological status and compare it with matched controls with adults with adult-onset SCI.","s":"Unknown","tr":[],"o":["Mental Health"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05421260","su":"https://scitrials.org/trial/NCT05421260"},{"n":"NCT06443281","t":"Pain Phenotyping in Patients With Neuropathic Pain After Spinal Cord Injury","d":"The development of neuropathic pain is one of the most debilitating sequels after a spinal cord injury (SCI). The overall aim of this study is to investigate potential underlying pathophysiological mechanisms of neuropathic pain after SCI. The functionality of the nociceptive pathway in humans as well as its plastic changes following SCI will be inferred with sophisticated sensory and pain phenotyping using quantitative sensory testing (i.e., psychophysical measures), objective…","s":"Recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06443281","su":"https://scitrials.org/trial/NCT06443281"},{"n":"NCT06698224","t":"Paired Spinal Cord and Peripheral Nerve Stimulation to Recover Hand Function in SCI","d":"Individuals who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles. This project aims to test the effects of pairing spinal cord and nerve stimulation combined with physical therapy training in recovering arms and hand function. The long-term goal is to provide better therapies that will improve the ability of individuals with spinal cord injuries to use their arms and hands to perform everyday tasks…","s":"Not yet recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06698224","su":"https://scitrials.org/trial/NCT06698224"},{"n":"NCT07814313","t":"Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury","d":"This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments. Experiment 1 will assess corticospinal and reticulospinal tract transmission to lower-limb muscles in older adults with and without SCI. Experiment 2 will examine how aging and spinal cord injury affect the body's ability to strengthen nerve pathways involved…","s":"Recruiting","tr":["Observational"],"o":["Leg Movement","Motor Function","Plasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07814313"},{"n":"NCT04854057","t":"Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI","d":"The purpose of this study is to test the efficacy of mild breathing bouts of low oxygen (intermittent hypoxia) combined with transcutaneous electrical spinal cord stimulation on restoring hand function in persons with chronic incomplete spinal cord injury.","s":"Terminated","tr":["Electrical Stimulation","Intermittent Hypoxia","Transcutaneous Stimulation"],"o":["Arm Movement","Breathing Function","Hand Movement","Motor Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04854057"},{"n":"NCT00594178","t":"Palliative Strategies in Spinal Cord Injury (SCI)","d":"Spinal cord injury (SCI) leads to muscle atrophy, hyperreflexia and spasticity, symptoms that decrease quality of life and prevent effective rehabilitation. Previous findings from our labs found that a passive cycling exercise program, motorized bicycle exercise training (MBET), in adult spinally transected animals reduced muscle atrophy and normalized hyperreflexia. We found that MBET could prevent the onset of hyperreflexia after spinal transaction, that MBET could also be used to rescue from…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Bone Strength","Quality of Life","Spasticity"],"st":["Arkansas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00594178"},{"n":"NCT06089226","t":"Parameters Related to Physical Activity Level in SCI","d":"Spinal cord injury (SCI) is a devastating health condition associated with permanent disability and reduced life expectancy. It is stated that its annual incidence worldwide varies between 12.1 and 57.8 per million, and its prevalence varies between 236 and 1009 per million. SCI negatively affects the physical, psychological, and social well-being of individuals by causing sensory, motor, and autonomic dysfunction. The level of disability associated with SCI is different for each injury and…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Blood Pressure","Breathing Function","Mental Health","Motor Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06089226"},{"n":"NCT03434314","t":"Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging","d":"Aortic aneurysms represent the most common and dangerous aortic diseases. Although conventional aortic repair techniques cure the disease, there is a high risk of paraplegia particularly in extensive thoracoabdominal aneurysms due to impaired blood supply to the spinal cord. The PAPA-ARTiS trial will assess the clinical safety and efficacy of the MISACE (Minimally-Invasive Segmental Artery Coil-Embolization) procedure, a novel therapeutic concept to reduce the risk of paraplegia due to aneurysm…","s":"Unknown","tr":[],"o":[],"st":[],"co":["Austria","France","Germany","Italy","Netherlands","Poland","Sweden","Switzerland","United Kingdom"],"lc":29,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03434314"},{"n":"NCT00204100","t":"Paraplegic Cycling: Improving Health After Spinal Cord Injury","d":"Surface electrical stimulation has for many years been widely used to retrain paralysed muscle and achieve the functions of standing and stepping. Recently a number of centres have used electrical stimulation of the leg muscles to achieve cycling. During cycling the quadriceps and hamstring muscles (thigh muscles) (and sometimes also the gluteal (buttocks) muscles) are stimulated to obtain a cycling motion. Stimulation is applied using adhesive electrodes placed on the surface of the skin. This…","s":"Unknown","tr":["Functional Electrical Stimulation (FES)"],"o":["Bone Strength"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00204100","su":"https://scitrials.org/trial/NCT00204100"},{"n":"NCT03459885","t":"PAS for Lower Extremity Rehabilitation in Tetraplegic Patients","d":"The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles (1,2). In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and investigate its effectiveness for lower extremity rehabilitation.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Motor Function"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03459885"},{"n":"NCT05362422","t":"PAS for Post-SCI Neuropathic Pain","d":"The investigators have shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles. In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI and SCI- associated neuropathic pain, and investigate its effectiveness for neuropathic pain treatment.","s":"Completed","tr":["Devices"],"o":["Motor Function","Pain Management"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05362422"},{"n":"NCT04101916","t":"PAS in Subacute SCI","d":"The investigators have recently shown in incomplete SCI patients that long-term paired associative stimulation is capable of restoring voluntary control over some paralyzed muscles and enhancing motor output in the weak muscles. In this study, the investigators will administer long-term paired associative stimulation to patients with incomplete cervical level SCI at the subacute stage, and investigate its effectiveness for upper extremity rehabilitation.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04101916"},{"n":"NCT05059405","t":"Pashto Translation of Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Pain Scale","d":"There is a need for a culturally adapted screening tool to aid health care professionals or clinicians screen for the presence of neuropathic pain associated with spinal cord injuries in Pashtoon population. . Since Paraplegic center Hayatabad Peshawar is a reputable institute for spinal cord injury patients' rehabilitation in Khyber pakhtun khwa where most of Pashto speaking SCI patients are rehabilitated. While working there as a physical therapist I, my other colleagues and patients felt a…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Pain Management"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05059405"},{"n":"NCT07390591","t":"Patient and Caregiver Perspectives on Intravesical Instillations for Urinary Symptoms","d":"The goal of this observational qualitative study is to learn about the experiences and perspectives of patients with neurogenic lower urinary tract dysfunction (NLUTD) and their caregivers regarding different types of intravesical instillations used for urinary health. The study aims to understand the perceived benefits, challenges, and opportunities related to Lactobacillus-only, gentamicin-only, and combined gentamicin-Lactobacillus instillations. The main question this study seeks to answer…","s":"Recruiting","tr":["Drugs"],"o":["Bladder Function"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07390591","su":"https://scitrials.org/trial/NCT07390591"},{"n":"NCT07139652","t":"Patient and Clinician Perceptions of Safe Ambulation in Incomplete Spinal Cord Injury","d":"This observational cross-sectional study aims to investigate the relationship between patient and therapist perceptions of safe ambulation and objective clinical outcomes in individuals with incomplete spinal cord injury (iSCI). Adults with iSCI at T3 or lower levels (ASIA C or D) admitted to an inpatient rehabilitation program are assessed for walking status using the Walking Index for Spinal Cord Injury II (WISCI II), including patient-rated and therapist-rated levels. Secondary outcomes…","s":"Completed","tr":["Devices","Observational","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07139652"},{"n":"NCT02616081","t":"Patient Reported Outcomes for Bladder Management Strategies in Spinal Cord Injury","d":"The investigators goal is to create a better understanding of patient reported outcomes for bladder management strategies (clean intermittent catheterization (CIC), indwelling catheter (IDC) and bladder surgery.","s":"Completed","tr":["Devices","Observational","Surgical Procedure"],"o":["Bladder Function","Quality of Life"],"st":["Michigan","Minnesota","Utah"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02616081"},{"n":"NCT03257982","t":"Patient Self-managed BCI-FES","d":"This study aims to assess the feasibility of therapist-caregiver-patient training to use BCI and FES technology with a view to the inexpensive equipment eventually being used for home use by tetraplegic patients as a continuing rehabilitation method for sub-acute patients discharged from hospital.","s":"Completed","tr":["Brain Machine Interface (BMI)","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Hand Movement","Mental Health","Motor Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03257982"},{"n":"NCT05811884","t":"Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury","d":"The goal of this clinical trial is to assess the efficacy of the use of powered exoskeleton for ambulation on the quality of life in subjects with spinal cord injury. The main questions it aims to answer are: 1. How much does the use of powered exoskeleton improve the quality of life in subjects with spinal cord injury after a 24 months treatment period in a house context (treatment 1) or in a clinical setting (treatment 2)? 2. How much do the two treatments differ in terms of cost-utility…","s":"Suspended","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05811884"},{"n":"NCT06531304","t":"Patient-therapist INTERaction During RObotic GAIT Rehabilitation After Spinal Cord Injury","d":"INTERROGAIT will disentangle the role of Physical Therapist - Patient (Pht-Pt) interaction in robotic assisted gait rehabilitation in spinal cord injury patients. The study is structured as a single blind randomized controlled trial with two arms, in which effects of different Pht-Pt interaction levels will be assessed on the ongoing robotic treatment with the Lokomat device. The main hypothesis is that when Pht-Pt interaction is maximized (experimental group), this will allow to better…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06531304"},{"n":"NCT03840928","t":"PatientSpot Formerly Known as ArthritisPower","d":"Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with rheumatoid arthritis (RA), spondyloarthritis (SpA), other musculoskeletal conditions, chronic neurological conditions like migraine, chronic pulmonary conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, autoimmune dermatological conditions such as…","s":"Unknown","tr":["Observational"],"o":["Blood Pressure","Bone Strength","Bowel Function","Breathing Function","Pain Management"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03840928"},{"n":"NCT01005615","t":"Patterned Functional Electrical Stimulation (FES) Ergometry of Arm and Shoulder in Individuals With Spinal Cord Injury","d":"To determine whether functional electrical stimulation (FES) promotes neurological and physical recovery in patients with spinal cord injury (SCI). The researchers will investigate the extent of functional recovery in patients with spinal cord injury who receive functional electrical stimulation in the upper extremities compared with patients who do not receive FES.","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Hand Movement","Spasticity"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01005615"},{"n":"NCT03559036","t":"Pediatric Locomotor Training Bladder Study","d":"Bladder dysfunction is one of the most important factors influencing duration and quality of life in children with spinal cord injury. Effective bladder control comprises a major aspect of a child's life with SCI and is especially challenging due to the rapid changes in a child's physical and cognitive development. Urological consequences secondary to a neurogenic bladder are responsible for many clinical complications post-spinal cord injury, including repeated urinary tract infections…","s":"Unknown","tr":["Rehabilitation"],"o":["Bladder Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03559036","su":"https://scitrials.org/trial/NCT03559036"},{"n":"NCT05117827","t":"Pediatric Powered Wheelchair Standing Devices: An Exploratory Study","d":"For children who use a power wheelchair, a powered wheelchair standing device (PWSD) may be considered for daily use. A PWSD allows a child to electronically move between sitting and standing and can be driven in either position. Existing published PWSD research in pediatrics is limited to boys with Duchenne muscular dystrophy (DMD).(1, 2) While these studies provide some insights into PWSD use in boys with DMD, they do not reflect PWSD use in children with other conditions. The purpose of this…","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05117827","su":"https://scitrials.org/trial/NCT05117827"},{"n":"NCT00205205","t":"Peer Mentoring for Persons With Spinal Cord Injury (SCI)","d":"A peer mentoring program for persons with SCI was developed. Individuals who experienced SCI in the past and have adapted well functionally were asked to serve as mentors for individuals with newly-acquired SCI. These individuals undergo volunteer and peer mentoring training prior to mentoring activities. They are a subset of the study participants. We are tracking their satisfaction with life, positive and negative affect, life adjustment, depression, and social support over time. We…","s":"Completed","tr":[],"o":["Mental Health"],"st":["Wisconsin"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00205205"},{"n":"NCT00786786","t":"Perceived Barriers to Exercise in Individuals Living With Spinal Cord Injury","d":"Purpose: This project is designed to identify what the key barriers to participating in exercise are for the general population of people living with spinal cord injury (SCI) in the United States (US).","s":"Completed","tr":["Observational"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00786786"},{"n":"NCT03392155","t":"Performance and Nutrition Program for Athletes in Adaptive Sports","d":"Researchers are trying to evaluate and recommend sustainable and effective health and wellness programs for people with spinal cord injury (SCI) and other physical disabilities.","s":"Completed","tr":["Nutrition"],"o":["Quality of Life"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03392155"},{"n":"NCT02132702","t":"Performance Attributes and User Progression While Using Ekso","d":"This study is to evaluate the performance attributes and user progression of participants with motor complete and incomplete spinal cord injury (SCI) while utilizing the Ekso robotic exoskeleton in an eight week over ground, locomotor program. We hypothesize an improvement in progression and overall health while using Ekso.","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Bladder Function","Blood Pressure","Bowel Function","Motor Function","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Denmark","Germany","Netherlands","Norway","Spain","Sweden","Switzerland"],"lc":9,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02132702"},{"n":"NCT04707144","t":"Performance Evaluation of a 3D PSIR Sequence in MRI at 1.5T","d":"Inclusion visit (D0): * verification of inclusion and non-inclusion criteria * information and collection of consent * standard imaging protocol prescribed as part of the usual treatment: sagittal T1 and T2 slices after injection of contrast product (Gadolinium), o 3D STIR sequence. * 3D PSIR sequence at the level of the cervical cord for the duration of the additional sequence is 10 minutes, for a total examination time of 45 minutes (instead of 35 minutes).","s":"Completed","tr":["Devices","Drugs","Observational"],"o":[],"st":[],"co":["France"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04707144"},{"n":"NCT01973257","t":"Perfusion and Diffusion Mechanism of Intervertebral Disc-Significance With Age, Degeneration, Posture and Stress Loading.","d":"The purpose of our study is to evaluate the perfusion of the IVDs and their diffusion ability by using the Dynamic contrast-enhanced MR perfusion technique and Diffusion weighted image with ADC value measurement, and to determine the relationship between these data and the degeneration of IVDs, the different posture, and different stress-loading status.","s":"Completed","tr":[],"o":["Trunk Control"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01973257"},{"n":"NCT06709664","t":"Perimenopause and Menopause in Women With Spinal Cord Injury","d":"A lot of information is known about how the perimenopause and menopause affects able bodied women. However there is very little information about how these affects women with spinal cord injury. This questionnaire study aims to collect information from women with a spinal cord injury on their experiences of going through the perimenopause and/or the menopause.","s":"Not yet recruiting","tr":[],"o":["Sexual Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06709664","su":"https://scitrials.org/trial/NCT06709664"},{"n":"NCT04618978","t":"Periodic Leg Movements' Diagnosis in Spinal Cord Injury: Actigraphy as an Alternative for Polysomnography?","d":"Periodic Limb Movements during Sleep (PLMs) are episodes of repetitive, stereotypical, hallux or foot movements. They could induce sleep disturbance, fatigue, daytime sleepiness and impaired quality of life but also increased cardiovascular risk by rising heart rate and blood pressure at night. Gold standard for PLMs diagnosis is based on electromyographic recording of tibialis anterior muscle during full night polysomnography (PSG). PLMs prevalence is higher in patients with spinal cord injury…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Leg Movement","Mental Health","Quality of Life"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04618978"},{"n":"NCT06314594","t":"Personalized Prevention and Treatment Strategies for Adolescent Idiopathic Scoliosis Via a Comprehensive Health Management Platform","d":"Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden. This trial aims to compares Jiaji electroacupuncture (JEA) and scalp electroacupuncture (SEA) in SCI rehabilitation. This randomized controlled trial (RCT) compared JEA and SEA in SCI rehabilitation.","s":"Recruiting","tr":["Rehabilitation"],"o":["Bladder Function","Mental Health"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06314594"},{"n":"NCT04027972","t":"Pharmacokinetics of Neostigmine and Glycopyrrolate","d":"A group of 6 able-bodied healthy volunteers will receive Neostigmine (NEO) and Glycopyrrolate (GLY) intravenously and via 2 methods of Iontophoresis (ION): one-patch and two-patch administration, with subsequent blood draws over 1 hour in order to measure the pharmacokinetic behavior of the drugs in-vivo.","s":"Completed","tr":["Devices","Drugs"],"o":["Bladder Function","Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04027972"},{"n":"NCT05708274","t":"Pharmacological Agents for Chronic Spinal Cord Injury (SCI)","d":"The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs (cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses when delivered in combination with hand training exercises in people with chronic spinal cord injury. The goal is to learn how to better strengthen connections between the brain and spinal cord after spinal cord injury, and if this connection is improved by one(or more) of the drugs. Multiple aspects of nerve…","s":"Completed","tr":["Drugs","Electrical Stimulation"],"o":["Blood Pressure","Hand Movement","Motor Function","Plasticity"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05708274"},{"n":"NCT06677229","t":"Phase 1b/2a Clinical Trial to Determine the Safety, Tolerability and Efficacy of TZ-161 in Spinal Cord Injury","d":"Technophage identified a promising compound, Eletriptan hydrobromide, that intends to use as a repurposed drug, for the treatment of acute spinal cord injury (SCI) in human subjects. Eletriptan hydrobromide is a well characterized molecule, that has been clinically available for over two decades for the treatment of migraines. It presents a good and manageable safety profile, including for the regimen selected for this trial, and it is generally well tolerated, with minimal side effects. This…","s":"Recruiting","tr":[],"o":["Regeneration"],"st":[],"co":["Spain"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06677229","su":"https://scitrials.org/trial/NCT06677229"},{"n":"NCT04475224","t":"Phase 3 Study of KP-100IT in Subjects With Acute Spinal Cord Injury","d":"This study is non-randomized, multicenter, confirmatory study by intrathecal administration of KP-100IT, code of HGF (Hepatocyte Growth Factor ) formulation for intrathecal injection, in subjects with acute spinal cord injury.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Japan"],"lc":5,"rlc":5,"cu":"https://clinicaltrials.gov/study/NCT04475224","su":"https://scitrials.org/trial/NCT04475224"},{"n":"NCT02193334","t":"Phase I/II Study of KP-100IT in Acute Spinal Cord Injury","d":"This study is randomized, double-blind, placebo-controlled Phase I/II study designed to evaluate safety and efficacy of KP-100IT, code of Hepatocyte Growth Factor (HGF) formulation for intrathecal injection, as a treatment for acute spinal cord injury. The study is conducted at two clinical sites in Japan.","s":"Completed","tr":["Drugs"],"o":["Motor Function","Sensory Function"],"st":[],"co":["Japan"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02193334"},{"n":"NCT00004812","t":"Phase II Randomized Pilot Study of Body Weight Support and Treadmill Training for Chronic Thoracic Spinal Cord Injury","d":"OBJECTIVES: I. Assess the ability of patients with and without sensorimotor loss below the thoracic spinal cord injury to execute coordinated whole-limb synergies sufficient for walking with full or partial weight support. II. Promote weight bearing, balance, and reciprocal leg movement in these patients. III. Elicit synchronized motor output within and between limbs in these patients.","s":"Completed","tr":["Rehabilitation"],"o":["Leg Movement","Motor Function","Trunk Control","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00004812"},{"n":"NCT03175055","t":"Phoenix Exoskeleton for SCI Users","d":"This study will evaluate the Phoenix device for safety and effectiveness at allowing persons with SCI who are non-ambulatory or poorly ambulatory to stand up and walk under a variety of conditions.","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Walking Function"],"st":["California","Texas"],"co":["Hong Kong","United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03175055"},{"n":"NCT04864262","t":"Photovoice for Spinal Cord Injury to Prevent Falls","d":"Falls is a health crisis that costs health care systems billions of dollars each year. This crisis is especially relevant for people living with spinal cord injury (SCI) as most of these people will fall at least once per year. Falls can cause injury and a fear of falling, which often causes people to restrict their mobility and daily activities. Despite its importance, fall prevention for people with SCI is understudied, and as a result, there is a lack of treatments to address their high fall…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life","Trunk Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04864262"},{"n":"NCT01368172","t":"Physical Activity Guidelines for People With Spinal Cord Injury (SCI)","d":"The first evidence-based physical activity guidelines for people with spinal cord injury were released in March, 2011. This project will evaluate the implementation of the new physical activity guidelines in a community exercise setting in Hamilton, Ontario. The investigators hypothesize that persons who follow the guidelines will experience increased aerobic fitness and muscle strength. The investigators also hypothesize that participants will find the guidelines easy to follow and that their…","s":"Completed","tr":[],"o":["Motor Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01368172"},{"n":"NCT04234269","t":"Physical Activity Scale in Individuals With Spinal Cord Injury","d":"The aim of this study was to improve the cultural adaptation and Turkish version of the The Physical Activity Scale for Individuals With Physical Disabilities (PASIPD) and to investigate the validity and reliability of the Turkish version of PASIPD in individuals with spinal cord injury. PASIPD, which consists of 13 questions, will be adapted to Turkish by translation and back translation method. The study included 47 wheelchair-dependent patients over the age of 18 who were able to read and…","s":"Completed","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04234269"},{"n":"NCT03420170","t":"Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI)","d":"This is a single blind randomized controlled trial study which will conducted on people with paraplegia wheelchair users. The objectives of this study is to investigates the effects of 16 weeks of 'Graded Exercise Integrated Education' over conventional physical therapy on physical fitness, exercise self-efficacy and the level of physical activity. There will be a significant difference between the experimental and control group.","s":"Unknown","tr":["Rehabilitation"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03420170","su":"https://scitrials.org/trial/NCT03420170"},{"n":"NCT00011544","t":"Physical Performance Measures for Manual Wheelchair Users","d":"The project is intended to modify the Functional Independence Measure (FIM) for manual wheelchair users. It will determine if the new measure is a better measure of community independence for manual wheelchair users than the FIM. During the Phase 1 of the study it will then use this new measure to determine whether a home exercise program increases functional independence in wheelchair users. In Phases II and III of the study 120 manual wheelchair users will participate to test and validate the…","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00011544"},{"n":"NCT05458947","t":"Physical Therapy Wound Care Modalities in Patients With Spinal Cord Injury (SCI)","d":"To examine the effects of Physical Therapist (PT) wound care modalities (pulsed wound irrigation (PWI) + electrical stimulation (ES), PWI only, and ES only) on wound healing in patients with spinal cord injuries (SCI).","s":"Recruiting","tr":[],"o":["Pressure Sores"],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05458947","su":"https://scitrials.org/trial/NCT05458947"},{"n":"NCT01696851","t":"Physiological and Psycho-social Variables of People With a Spinal Cord Injury Participating in Competitive Rugby in Wheelchairs","d":"People with Spinal cord injury with tetraplegia suffer from respiratory problem due to weakness of the muscles and because the autonomic system dysfunction. Exercise is one way of preserving and improving physical fitness and directly and indirectly reduce risk factors such as insulin resistance, weight loss and low values of HDL. subjects with spinal cord injury with tetraplegia have limited options for exercise: table tennis, gym, pool and more. Because of the nature of the injury which…","s":"Withdrawn","tr":["Observational"],"o":["Breathing Function","Mental Health","Quality of Life"],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01696851"},{"n":"NCT04286191","t":"Physiological Changes Induced Through MEP Conditioning in People With SCI","d":"The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a result of this type of training. After spinal cord injury, brain-to-muscle connections are often interrupted. Because these connections are important in movement control, when they are not working well, movements may be disturbed. Researchers have found that people can…","s":"Completed","tr":["Transcranial Magnetic Stimulation (TMS)"],"o":["Motor Function","Quality of Life","Spasticity","Walking Function"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04286191"},{"n":"NCT07674927","t":"Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury","d":"This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI. Up to 15 participants aged 18 years or older with non-progressive SCI will be enrolled. Participants will complete supervised gait training using the MedRhythms device twice weekly during regularly scheduled physical therapy sessions over a six-week period. The device uses shoe-mounted…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07674927"},{"n":"NCT05888714","t":"Pilot Study for Peripheral Neuromuscular Electrical Stimulation of the Quadriceps Muscle","d":"Feasibility study of a new medical device that will evaluate the usability and effectiveness of a cycle ergometer device associated with neuromuscular electrical stimulation (FES cycling). The study's objective is to evaluate the effect of the application of functional electrical stimulation of the new device on participants' quadriceps muscle strength in comparison to a medical device with similar characteristics and to a control group. Secondarily, the study will compare the usability of the…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05888714","su":"https://scitrials.org/trial/NCT05888714"},{"n":"NCT06957483","t":"Pilot Study of a Sedentary Behaviour Intervention for Individuals With a Spinal Cord Injury","d":"Individuals with spinal cord injury have a greater risk of heart disease and stroke than non-disabled individuals. This might be partly because wheelchair users engage in high amounts of sedentary behaviour. A review found a lack of programmes aimed at reducing sedentary behaviour in individuals with paraplegia. This means we do not know how good these programmes are for reducing heart disease risk markers. A programme to support reductions in sedentary behaviour has been co-designed with…","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06957483","su":"https://scitrials.org/trial/NCT06957483"},{"n":"NCT02974673","t":"Pilot Study of Ejaculatory Dyssynergia by Electronic Microsensors of Sphincters","d":"The objective of this research is to study the sphincter activity during ejaculation in patients with spinal cord injury in order to detect an ejaculatory dyssynergia. For this purpose, using a catheter the protocol plans to measure the sphincter pressures during ejaculation. Moreover, cardiovascular parameters will be measured continuously during the ejaculatory test.","s":"Terminated","tr":["Devices"],"o":["Bladder Function","Blood Pressure"],"st":[],"co":["France"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02974673"},{"n":"NCT05253989","t":"Pilot Study of EMG-Directed Virtual-Reality Experience Training for Motor Stroke Rehabilitation","d":"Novel approaches are needed for the management of stroke patients, as current practice relies on the presence of a qualified professional, of which there are severe shortages. Rehabilitation technologies provide a unique solution to this problem. Recent technological advances in EMG signal processing mean that researchers are now able to decompose EMG recordings of the residual muscle activity of stroke survivors. This information can be used to detect biomarkers of a patient's functional…","s":"Unknown","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Mental Health","Pain Management","Plasticity","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05253989"},{"n":"NCT01131884","t":"Pilot Study of Fosamax in Spinal Cord Injury","d":"Study is designed to evaluate the efficacy of oral fosamax in prevention on osteoporosis in acute spinal cord injury. Efficacy will be measured by a duel energy X-Ray absorptiometry (DEXA) scan every 6 months. Patients will complete 3 visits, screening, 6 months, 12 months and be required to take oral fosamax versus placebo weekly.","s":"Terminated","tr":["Drugs"],"o":["Bone Strength"],"st":["New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01131884"},{"n":"NCT07625332","t":"Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)","d":"The purpose of this research study is to measure the tolerability and preliminary efficacy of a drug, galantamine, to treat metabolic syndrome (MetS) by reducing circulating inflammation in people with spinal cord injury (SCI). Galantamine is FDA-approved for the treatment of Alzheimer's disease. Here, the drug is considered experimental for the purposes of this study.","s":"Recruiting","tr":["Drugs"],"o":["Quality of Life"],"st":["New Jersey","New York"],"co":["United States"],"lc":3,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07625332","su":"https://scitrials.org/trial/NCT07625332"},{"n":"NCT03105882","t":"Pilot Study of the Neuro-Spinal Scaffold for the Treatment of AIS A Cervical Acute SCI","d":"Pilot Study of Clinical Safety and Feasibility of the Neuro-Spinal ScaffoldTM for the Treatment of Complete (AIS A) Traumatic Acute Spinal Cord Injury at the C5-T1 Neurological Levels The purpose of this study is to support an expansion to support marketing applications as well as future studies.","s":"Withdrawn","tr":["Devices","Safety"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03105882"},{"n":"NCT05142111","t":"Pilot Study on EEG and Behavioral Effects of Two Different Treatments on Sexual Life","d":"In this study patients with Multiple Sclerosis or Spinal Lesions will participate in two different types of treatments that aim to improve sexual and sentimental life. Behavioral (via questionnaires) and brain (via high-density electroencephalogram) effects associated with treatment will be studied.","s":"Unknown","tr":[],"o":["Sexual Function"],"st":[],"co":["Italy"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05142111","su":"https://scitrials.org/trial/NCT05142111"},{"n":"NCT00919581","t":"Pilot Study: The Role of Macrophage Migration Inhibitory Factor (MIF) in Spinal Cord Injury","d":"The purpose of the study is to investigate inflammatory and other substances that may be elevated in the blood and blood cells following spinal cord injury (SCI). These substances will be evaluated in samples from people who have had a spinal cord injury due to trauma (e.g. car accident or a fall) within the first week (acute) or at least one year ago (chronic). Specifically, the study will evaluate the presence and levels of a protein, macrophage migration inhibitory factor (MIF). MIF is…","s":"Completed","tr":["Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00919581"},{"n":"NCT04872569","t":"Pilot Testing A Pregnancy Decision Making Tool for Women With Spinal Cord Injury (SCI)","d":"The purpose of this project is to pilot test a decision-making tool that is tailored for women with SCI to support them in the decision-making process. Pilot testing focuses on feasibility and preliminary efficacy.","s":"Completed","tr":[],"o":[],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04872569"},{"n":"NCT07562113","t":"Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery","d":"This study looks at a treatment called transcutaneous auricular vagus nerve stimulation, or taVNS. taVNS uses a small device worn on the ear to gently stimulate a nerve. Researchers want to find out if this treatment is safe and well-tolerated for people who recently had a spinal cord injury (SCI). This study will also help researchers learn whether taVNS can be safely added to standard mobility therapy, and whether it might help improve mobility. This study has two main goals: 1. To find out…","s":"Not yet recruiting","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":[],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07562113","su":"https://scitrials.org/trial/NCT07562113"},{"n":"NCT02148887","t":"Plasticity of Grey and White Matter in Response to Motor Skill Training in Healthy Individuals and Those With Spinal Cord Injury","d":"We aim to investigate the effect of motor skill training of the upper and lower limbs on the function and structure of the CNS as measured by neuroimaging parameters sensitive to changes in tissue volume and density and the properties of myelin.","s":"Completed","tr":["Observational"],"o":["Leg Movement","Plasticity","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02148887"},{"n":"NCT01355549","t":"Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury","d":"Shoulder pain is common in persons with spinal cord injury (SCI). It is most often caused by overuse injuries to the muscles and tendons that can occur during wheelchair propulsion, transfers, and other activities of daily living. Normally, shoulder pain resolves with conservative treatments such non-steroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, naproxen, etc.) and physical therapy. However, when these treatments fail, shoulder surgery may be the only option. Platelet Rich Plasma…","s":"Completed","tr":["Rehabilitation","Surgical Procedure"],"o":["Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01355549"},{"n":"NCT04054414","t":"PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury","d":"This was a prospective, multicentric, randomized, double blind, parallel, saline controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 (INN: Sovateltide) therapy along with standard supportive care in patients of acute spinal cord injury.","s":"Recruiting","tr":["Safety"],"o":[],"st":[],"co":["India"],"lc":5,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT04054414","su":"https://scitrials.org/trial/NCT04054414"},{"n":"NCT07810712","t":"PNS Motor Stimulation Study","d":"Paralysis is one of the most disabling features of Spinal cord injury and stroke. In select cases, where the nerve is intact, stimulation can achieve meaningful muscle contraction e.g. to restore grip and release function. Previously, products to serve this purpose had been developed and successfully implanted (Freehand device). However, they had technical and cost limitations and have gone out of production. We aim to investigate if a simple implantable and commercially available system could…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Hand Movement","Motor Function","Pain Management"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07810712"},{"n":"NCT04185792","t":"Polish Translation and Validation of NBSS, Qualiveen and SF-Qualiveen","d":"The aim of this study is to translate, culturally adapt, and validate Polish versions of the NBSS, Qualiveen and SF-Qualiveen questionnaires.","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Poland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04185792"},{"n":"NCT02459028","t":"Positive Psychology Interventions in Individuals With Chronic Pain and Spinal Cord Injury","d":"Background: Chronic pain is one of the most burdensome potential consequences of a physical disability, such as spinal cord injury (SCI). Estimates of the incidence of chronic pain in SCI range between 65 - 80%. A recent pilot-study of a computer-based tailored positive psychology intervention showed a significant reduction in pain intensity, pain interference, pain catastrophizing and depression and an enhancement of subjective well-being and control over pain in persons with chronic pain…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02459028"},{"n":"NCT00929422","t":"Positron Emission Tomography (PET) in Evaluating Cerebral Glucose Metabolism and Functional Change for Patients With Spinal Cord Injury","d":"Background: Spinal cord injury (SCI) results in dysfunction of motor and sensory system and the hormonal secretion. Not only the change of peripheral hormonal organs, the central neurotransmitters were also affected. We consider there are some changes in cerebral physiology, anatomy or function after SCI. Objective: Use PET imaging to investigate the brain functional difference among the SCI and control group.","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00929422","su":"https://scitrials.org/trial/NCT00929422"},{"n":"NCT07594574","t":"Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury","d":"This randomized controlled trial compares posterior minimally invasive correction surgery with conventional posterior spinal fusion for children with paralytic scoliosis and severe pelvic obliquity following spinal cord injury. Conventional posterior spinal fusion is widely used for severe neuromuscular or paralytic scoliosis but is associated with substantial surgical trauma, blood loss, transfusion requirements, and perioperative morbidity. The minimally invasive approach uses limited…","s":"Active, not recruiting","tr":["Surgical Procedure"],"o":["Trunk Control"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07594574"},{"n":"NCT07801274","t":"Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases","d":"This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases. Spinal metastases can press on the spinal cord and cause pain, weakness, or paralysis. This treatment uses higher doses of radiation in fewer sessions (hypofractionated stereotactic body radiotherapy) delivered precisely by the Edge machine to target remaining tumor cells while protecting the spinal cord. The study aims to see if this approach…","s":"Recruiting","tr":["Epidural Stimulation","Observational","Surgical Procedure"],"o":["Pain Management","Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07801274"},{"n":"NCT07527728","t":"Postoperative Neurological Recovery and Risk Factor Analysis in Patients With Paralysis Due to Spinal Metastases","d":"Metastatic spinal tumors represent a common and devastating complication in patients with advanced solid malignancies. Up to 40% of cancer patients may develop spinal metastases during the course of their disease, often resulting in intractable pain, neurological deficits, and spinal instability. One of the most serious consequences is motor paralysis caused by metastatic epidural spinal cord compression (MESCC), which can severely impair patients' quality of life and limit their ability to…","s":"Not yet recruiting","tr":["Devices","Drugs","Epidural Stimulation","Observational","Surgical Procedure"],"o":["Bladder Function","Bowel Function","Motor Function","Pain Management","Quality of Life","Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07527728"},{"n":"NCT03691532","t":"Postprandial Lipid Tracer and Exercise in Spinal Cord Injury","d":"This study investigates the effect of upper extremity exercise on postprandial lipemia (PPL) in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON) or arm cycling exercise (ACE). The meal is infused with \"stable isotope lipid tracers\" that allow for determination of the end fates of the fat in the meal.","s":"Completed","tr":[],"o":["Arm Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03691532"},{"n":"NCT01980784","t":"Posttraumatic Changes in Energy Expenditure and Body Composition in Patients With Acute Spinal Cord Injury","d":"Severe trauma induces massive metabolic changes that are characterized by hypermetabolism with increased energy expenditure and catabolism. Early enteral and, if necessary, parenteral feeding is a major focus of modern intensive care medicine. After acute spinal cord injury, denervation of skeletal muscle leads to a massive loss of muscle mass in the area below the level of injury. This dramatic muscle atrophy again leads to a decrease in energy expenditure. Whereas other survivors of severe…","s":"Completed","tr":["Nutrition","Observational","Rehabilitation"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01980784"},{"n":"NCT07738913","t":"Postural Control Mechanism During a Stationary Wheelchair Wheelie","d":"The purpose of this study was to investigate the postural control during a stationary wheelchair wheelie. A group of participants was recruited for this observational study. Participants were asked to perform and maintain the stationary phase of a wheelchair wheelie, during which kinematic and kinetic data were recorded.","s":"Completed","tr":["Observational"],"o":["Trunk Control"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07738913"},{"n":"NCT03810781","t":"Postural Stability in Cervical Spinal Myelopathy","d":"Veterans are at heightened risk of developing cervical spondylotic myelopathy (CSM) from rigors of military service. Balance and posturography are negatively affected in CSM, but require expensive equipment, and extensive training of personnel for data acquisition and interpretation. The Virtual Environment TBI Screen (VETS) is a simple and inexpensive construct that could be implemented as an aid in diagnosis and as an objective means to compare treatment modalities and track recovery. The…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Trunk Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03810781"},{"n":"NCT01800604","t":"Power Over Pain (POP) Study","d":"Many individuals with multiple sclerosis (MS), spinal cord injury (SCI), acquired amputation (AMP), muscular dystrophy (MD), and low back pain (LBP) experience pain. There has been little research on how to treat this pain. Different types of treatment that include self-hypnosis, education about chronic pain, and learning skills on how to change how a person thinks about his/her pain have been used to treat chronic pain in the general population. The purpose of this study is to see if these…","s":"Completed","tr":[],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01800604"},{"n":"NCT04568928","t":"Powered Exoskeleton Combined With Functional Electrical Stimulation in Clinical Practice","d":"After partial spinal cord injury, gait deficits may be present and often remain even after intensive rehabilitation. New robotic technologies have recently emerged to help augment the extent of rehabilitation. However, these are complex tools to integrate into clinical practice and little is known about the potential factors that may influence the uptake of a locomotor program using this technology by clinicians. The goal of this project is to bring together researchers, administrators…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04568928","su":"https://scitrials.org/trial/NCT04568928"},{"n":"NCT02658656","t":"Powered Exoskeletons in Persons With SCI","d":"Background Veterans with spinal cord injury (SCI) have many adverse secondary medical and quality of life (QOL) changes as a result of immobilization. Veterans with SCI who have completed rehabilitation after injury and are unable to ambulate receive a wheelchair as standard of care (SOC) for mobility. Powered exoskeletons are a technology that has recently become available as an alternate form of mobility by providing an external framework for support and computer controlled motorized hip and…","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Bowel Function","Mental Health","Quality of Life","Walking Function"],"st":["California","Florida","Georgia","Massachusetts","Minnesota","Missouri","New Mexico","New York","Ohio","Texas","Virginia","Wisconsin"],"co":["United States"],"lc":15,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02658656"},{"n":"NCT00175682","t":"Prazosin Vibrostimulation Autonomic Dysreflexia and Spinal Cord Injury Study","d":"Sexuality is a high rehabilitative priority for persons following a spinal cord injury (SCI). Sexual acts can lead to autonomic dysreflexia (AD), dangerous consequences such as a sudden increase in blood pressure, severe headache, sweating above the level of the lesion and low heart rate to name a few. Ejaculation in men can provoke these significant symptoms and therefore men and women may refrain from a sexual life and biological parenthood. Adalat is the most common antihypertensive used in…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Sexual Function","Temperature Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00175682"},{"n":"NCT03108859","t":"Pre-and In-hospital First Aid Programs and Specifications for Spine and Spinal Cord Injury in Beijing of China","d":"To establish a spine injury and spinal cord injury (SCI) treatment database; to complete pre- and in-hospital evaluation of spine injury and SCI, develop and optimize first aid procedures, form pre-and in-hospital standardized training program for the treatment of spine injury and SCI; to develop first aid guidelines and establish an evaluation and treatment system for early surgery, as far as possible to save the spinal cord function and reduce the degree of disability; to form expert…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["China"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03108859","su":"https://scitrials.org/trial/NCT03108859"},{"n":"NCT03987126","t":"Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction","d":"An investigator initiated pilot study: two arm, double blind, placebo controlled, randomized, group of approximately 60 patients with spinal cord injury, and who have evidence of neurogenic bladder. Patients will be treated with human milk oligosaccharide (HMO) versus placebo over 12 weeks from start of the investigational medication date (approximately 3 months) to test whether HMO can improve bowel motility in neurogenic bowel and bladder patients. Patients in the placebo arm of the study…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03987126"},{"n":"NCT06429735","t":"Precise Robotically IMplanted Brain-Computer InterfacE","d":"The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or tetraplegia. The N1 Implant is a skull-mounted, wireless, rechargeable implant connected to electrode threads that are implanted in the brain by the R1 Robot, a robotic electrode thread inserter.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["Arizona","Florida"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06429735","su":"https://scitrials.org/trial/NCT06429735"},{"n":"NCT01765153","t":"Precision Versus Endurance Training to Improve Walking After Chronic Incomplete SCI","d":"The objective of the study was to determine the efficacy of two forms of physical therapy training, one emphasizing precise, visually guided walking over obstacles and on targets (Precision Training), the other emphasizing mass practice of walking on a treadmill (Endurance Training). The hypothesis was that visually guided training (Precision) may be especially efficacious because it engages the motor cortex, whose input may facilitate improvements in functional walking. Participants are…","s":"Completed","tr":["Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Mental Health","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01765153"},{"n":"NCT01726881","t":"Predicting Central Pain Among People With a Spinal Cord Injury by Evaluating Mechanisms Regulating Pain and Efficacy Testing of the TENS Apparatus","d":"People with a Spinal Cord Injury can develop chronic pain within months of the injury. Up to 80% of the patients will develop chronic pain called \"central pain\" and describe the pain as: burning, stabbing, or \"like electricity.\" Central pain mechanism is unknown and therefore treatment is currently not effective. It is hypothesized that chronic pain is associated with impaired function of the systems regulating pain, however, this hypothesis has not been tested among Spinal Cord Injury…","s":"Unknown","tr":["Electrical Stimulation"],"o":["Pain Management"],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01726881","su":"https://scitrials.org/trial/NCT01726881"},{"n":"NCT05462925","t":"Prediction of Muscle Responsiveness to FES Therapy","d":"Reduced arm and hand function has a significant impact on independence and quality of life after spinal cord injury. Functional electrical stimulation therapy (FES-T) is a treatment that can produce improvements in reaching and grasping function after neurological injuries. However, not all paralyzed muscles respond equally well to the therapy. Currently, therapists cannot predict which muscles will respond, limiting their ability to create a personalized therapy plan that can maximize outcomes…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05462925"},{"n":"NCT02860689","t":"Predictive Factors for Male Sexual Dysfunction After Traumatic Spinal Cord Injury","d":"Objective: To analyze the association between sexual function of men with spinal cord injury with possible predictive factors for dysfunction.","s":"Completed","tr":["Observational"],"o":["Mental Health","Sexual Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02860689"},{"n":"NCT01479556","t":"Pregabalin for the Treatment and Prevention of Spinal Cord Injury Neuropathic Pain","d":"This study is a phase IV clinical trial with the objective of evaluating whether pain relief associated with pregabalin for at-level non-evoked and evoked neuropathic pain is more efficient during the early rather than late subacute phase of spinal cord injury.","s":"Unknown","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01479556","su":"https://scitrials.org/trial/NCT01479556"},{"n":"NCT01834417","t":"Preliminary Study Leading to Prevention of Pressure Ulcers by the Use of an On-board Device : Ergonomic Assessment of Wheelchair-seat Pressures in Spinal Cord Injured (SCI) Patients ( PRESDIE)","d":"Analysis of stored seat-pressures in SCI patients during a 4-week use of an on-board device. During this period, patients write in an agenda noteworthy events that could occur while they're using their wheelchair. A control is done every week and the device can be changed until it is returned at the end of the study period.","s":"Completed","tr":["Devices"],"o":["Pressure Sores"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01834417"},{"n":"NCT02001558","t":"Pressure Ulcer Healing With Microcyn","d":"The purpose of this study is to test how well Microcyn™ works on Stage 3 and Stage 4 pressure ulcers compared to sterile saline among persons with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Pressure Sores"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02001558"},{"n":"NCT01166828","t":"Pressure Ulcer Prevention for SCI Using a Tele Home Program","d":"NRI research focuses on nursing interventions that are patient-centered, culturally congruent, cost-effective and outcome-driven. High priority populations of interest are veterans with Spinal Cord Injuries (SCI). The development of innovative tele home techniques for preventing pressure ulcers in veterans with SCI is of high importance in the VA. Our findings may provide clinicians with improved methods for skin and wound assessment and more effective and efficient PUP strategies for Hispanic…","s":"Withdrawn","tr":[],"o":["Mental Health","Pressure Sores"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01166828"},{"n":"NCT01999816","t":"Pressure Ulcer Prevention Study in SCI","d":"The purpose of this study is to conduct a randomized controlled trial of a lifestyle redesign intervention's ability to (1)reduce the incidence of medically serious pressure ulcers and associated surgeries in adults with spinal cord injury, and (2)assess the intervention's cost-effectiveness and potential cost savings and its effects on participants' quality of life.","s":"Completed","tr":[],"o":["Pressure Sores","Quality of Life"],"st":["California"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01999816"},{"n":"NCT00448045","t":"Preventing Pneumonia and Other Respiratory Problems in Persons With Spinal Cord Injury","d":"It is known that individuals with spinal cord injury are at increased risk for respiratory tract infections like pneumonia. Part of this risk is due to weakened chest and abdominal muscles that are vital to deep breathing and the ability to cough. The purpose of this study is to look at the effectiveness of two different treatments in preventing pneumonia and other respiratory problems in persons with SCI. This is a randomized controlled trial investigating the effectiveness of two different…","s":"Completed","tr":[],"o":["Breathing Function","Quality of Life"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00448045"},{"n":"NCT00105859","t":"Preventing Pressure Ulcers in Veterans With Spinal Cord Injury (SCI)","d":"Pressure ulcers are a serious, costly, and life-long complication of spinal cord injury (SCI). Pressure ulcer prevalence has been estimated at between 17 and 33% among persons with SCI residing in the community. Epidemiological studies have found that 36-50% of all persons with SCI who develop pressure ulcers will develop a recurrence within the first year after initial healing (Carlson et al., 1992; Fuhrer et al., 1993; Goldstein, 1998; Niazi et al., 1997; Salzberg et al. 1998). Recurrence…","s":"Terminated","tr":["Surgical Procedure"],"o":["Pressure Sores"],"st":["Georgia","Tennessee","Texas","Virginia","Washington","Wisconsin"],"co":["United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00105859"},{"n":"NCT02591901","t":"Preventing UTIs in Chronic Neurogenic Bladder Dysfunction (Mix Methods)","d":"Due to the damage caused to the spinal cord, patients with spinal cord injury, cauda equina syndrome, multiple sclerosis and transverse myelitis may encounter loss of bladder function, which in turn can lead to a debilitating and costly complication: Urinary Tract Infections (UTIs). Given that these patients with loss of bladder function do not normally feel symptoms like pain - as would be the case in otherwise healthy persons - there is no clear agreement among experts on which signs and…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Pain Management"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02591901"},{"n":"NCT01698138","t":"Prevention of Bladder Dysfunction in Acute Spinal Cord Injury","d":"This study is a double blind, randomized, placebo controlled trial to explore the effect of early treatment with Onabotulinumtoxin A in patients with acute complete motor spinal cord injury (SCI) on the development of neurogenic detrusor overactivity (NDO). A total of 20 patients will be randomized to intra-detrusor injection of 300 U Onabotulinumtoxin A in 30 ml NaCl 0.9 % or placebo with 30 ml NaCl 0.9 %. Bladder biopsies will be obtained in the same procedure. The treatment will be repeated…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Norway"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01698138"},{"n":"NCT02325414","t":"Prevention of Bone Loss After Acute SCI by Zoledronic Acid","d":"The overall objective of this study is to define an effective therapeutic approach, using currently available medication, to prevent or mitigate the loss of bone mass and bone strength that occurs after acute spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bone Strength","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02325414"},{"n":"NCT05024487","t":"Prevention of Complications Due to Autonomic Dysreflexia in SCI Individuals","d":"Autonomic dysreflexia (AD) is a syndrome of unbalanced response of the sympathetic system to noxious stimuli below the level of spinal cord injury (SCI), characterized by paroxysmal hypertension. Mostly, it is combined with symptoms such as pounding headache, slowed heart rate, and upper body flushing, but it can also be asymptomatic. When resulting in hypertensive crisis, it can be life-threatening and result in seizures, cardiac arrest, retinal or subarachnoid hemorrhages, stroke, and even…","s":"Unknown","tr":[],"o":["Blood Pressure"],"st":[],"co":["Czechia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05024487","su":"https://scitrials.org/trial/NCT05024487"},{"n":"NCT01813240","t":"Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement","d":"Spinal cord trauma and the consequent paraplegia are possibly among the most devastating injuries in soldiers and during spine surgery, and are significant in the medical, social and financial aspects. Limited mobility, the need for assistance in all human activities, shame, and many medical complications related directly to the neural deficits make paraplegia an important target for prevention. Our study will evaluate the efficacy of Minocycline in two different groups: 1. Minimizing the…","s":"Unknown","tr":["Drugs"],"o":["Motor Function","Sensory Function"],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01813240","su":"https://scitrials.org/trial/NCT01813240"},{"n":"NCT00237770","t":"Prevention of Low Blood Pressure in Persons With Tetraplegia","d":"The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while upright in those with tetraplegia. If blood pressure is increased with NOS inhibition in persons with tetraplegia, this would improve our treatment of the condition of low blood pressure during seated postures in individuals with tetraplegia.","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00237770"},{"n":"NCT01891110","t":"Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI","d":"Background: The presence of orthostatic hypotension (OH) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (SCI) is a common condition. Aims: To investigate the impact of three different types of electric stimulation (ES) (ES of the abdominal muscles versus ES of lower limb muscles versus simultaneously ES of abdominal and lower limb muscles versus control) on blood pressure stabilization and verticalisation-degrees between 0° and 70°. The…","s":"Completed","tr":[],"o":["Blood Pressure","Leg Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01891110"},{"n":"NCT05484557","t":"Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury","d":"Currently, Enoxaparin is the usual prophylactic anticoagulant treatment at the acute and sub-acute phases of spinal cord injury (SCI). Patients at the sub-acute phase of SCI (rehabilitation) will be given either Enoxaparin 40 mg/day (control) or Apixaban 2.5-5 mg twice a day. Apixaban dose will be determined by the treating physician. Treatment will be continued for either 6 or 12 weeks following injury (for AIS grades C-D and A-B respectively). Endpoints: Venous thromboembolism will be…","s":"Recruiting","tr":["Drugs","Rehabilitation"],"o":[],"st":[],"co":["Israel"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05484557","su":"https://scitrials.org/trial/NCT05484557"},{"n":"NCT00309114","t":"Prevention of Urinary Tract Infection (UTI) in Persons With Spinal Cord Injury (SCI)","d":"Urinary tract infection (UTI) is the most common infection in patients with spinal cord injury (SCI) and is linked to major undesired results or complications including death. The bladder of SCI patients, especially those with indwelling catheters, is usually colonized by bacteria, some of which do and others which do not cause symptoms of UTI. Bacteria that do not cause symptoms are often called benign colonizers and are often left untreated because they may provide some protection against…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Quality of Life"],"st":["Georgia","Illinois","Texas"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00309114"},{"n":"NCT03111030","t":"ProACTIVE SCI Physical Activity Intervention","d":"This study will employ a randomized, wait-list controlled trial. A total of 30 participants (15 experimental, 15 wait-list control) between 18-65 years of age who have chronic SCI ≥ 1 year prior will be recruited. Physical activity measures will be taken using wrist-based accelerometers and the Leisure Time Physical Activity Questionnaire for people with SCI (LTPAQ). Psychosocial factors will be evaluated through questionnaires. The primary health outcome measure (aPWV), and secondary…","s":"Completed","tr":[],"o":["Blood Pressure","Mental Health"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03111030"},{"n":"NCT04659408","t":"Probiotic and Prebiotic Supplementation in Elite Athletes with Spinal Cord Injury","d":"The main objective of this pilot study is to obtain information, which will be used for the design of a main randomized controlled trial (RCT) with a larger size based on feasibility, validity and sample size estimation as well as the potential effects of pre- and probiotic intake on intestinal microbiota. A larger trial will then be designed to test the hypothesis that adding probiotics or prebiotics may improve gut microbiome composition, gastrointestinal symptoms as well as cardiometabolic…","s":"Completed","tr":["Nutrition"],"o":["Bowel Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04659408"},{"n":"NCT01861808","t":"Prognostic Value of Biochemical Markers in Cerebrospinal Fluid for Functional Outcome of Spinal Cord Injured Patients","d":"The project is aimed to develop predictive indices of spinal cord injury severity through the analysis of cerebrospinal fluid of patient collected during acute injury.","s":"Completed","tr":[],"o":[],"st":[],"co":["Italy"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01861808"},{"n":"NCT04265560","t":"Progressive Resistance Training in Acute Spinal Cord Injury","d":"Muscle weakness is one of the most common and debilitating symptoms following a Spinal Cord Injury (SCI). Strength training is recommended as an effective means to increase muscular strength and improve function for individuals with long term SCI. In contrast, the strength training guidance for those with a recent (\\<1 year) SCI is lacking. Therefore, this study aims to investigate the feasibility of a method of upper limb strengthening - Progressive Resistance Training (PRT) and its impact…","s":"Terminated","tr":["Rehabilitation"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04265560"},{"n":"NCT00592384","t":"Project to Improve Symptoms and Mood in People With Spinal Cord Injury","d":"Depression is likely the most prevalent and disabling psychological complication associated with spinal cord injury (SCI). Yet no controlled depression treatment trials have been performed in this population. The proposed study is a multi-site, randomized, double-blind, placebo controlled trial of venlafaxine XR (Effexor XR) in 133 adults with SCI and major depressive disorder (MDD) or dysthymia who are at least one month post injury. Participants will be recruited from four SCI Model System…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity"],"st":["Alabama","Florida","Illinois","Michigan","Texas","Washington"],"co":["United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00592384"},{"n":"NCT07440459","t":"Promoting Neuroplastic Mechanisms With Modeling-based Optimization of a Novel Robot-asisted Walking Rehabilitation Therapy","d":"The goal of this observational study is to assess the course of motor and functional gait recovery induced by Lokomat robot-assisted gait rehabilitation in patients with spinal cord injury. The main question it aims to answer is: How does gait motor and functional multilevel recovery progress over time in patients with spinal cord injury? Assessmets will be conducted at four time points: pre-intervention, mid-intervention, post-intervention, and at 1-month follow-up after the completion of…","s":"Completed","tr":["Observational","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07440459"},{"n":"NCT06176833","t":"Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury","d":"The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury. Specifically, the study will look at whether starting BWSTT, which uses a body harness to support body weight while walking on a treadmill at different times within the first 6 months after the injury, makes a difference in how effective this therapy may be, While we know that the…","s":"Recruiting","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Illinois","Texas"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06176833","su":"https://scitrials.org/trial/NCT06176833"},{"n":"NCT03543111","t":"Promoting the Psychological Health of Women With SCI: A Virtual World Intervention","d":"The purpose of this project is to test the efficacy of an internet-based psychological health enhancement program for women with spinal cord injury. The intervention will occur in Second Life (SL), which is an online virtual word simulator with a group of women with spinal cord injury.","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Montana","Texas"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03543111"},{"n":"NCT06066918","t":"Prophylactic Pregabalin Treatment Following Spinal Cord Injury","d":"Patients arriving to rehabilitation up to 3 months following SCI will be given (study group) or not (control group) Lyrica (75X2). They will be followed for central pain development.","s":"Recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["Israel"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06066918","su":"https://scitrials.org/trial/NCT06066918"},{"n":"NCT01974635","t":"Proprioception Testing in Persons With Sensorimotor Impairment","d":"In this study, an FDA-cleared device and type of treatment called \"AMES,\" which stands for Assisted Movement with Enhanced Sensation, will be used to determine whether sensation in the upper limb of individuals with incomplete spinal cord injuries, acquired brain injury, or stroke improves along with movement through treatment. We hypothesize that measureable improvement in the sensation of the upper limb will precede improvement in functional movement.","s":"Terminated","tr":["Devices"],"o":["Arm Movement","Sensory Function"],"st":["Oregon"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01974635"},{"n":"NCT02796235","t":"Prospective and Monocentric Study of the Incidence of Venous Thromboembolic Disease (VTE) in Spinal Cord Injury (SCI) Patient Between 3 and 12 Months After SCI","d":"Venous Thromboembolic Disease (VTE) in SCI patients is very common, its prevalence is 60 to 80% against 10-20% in the general population. The risk of VTE is very important in the first weeks after spinal cord injury, and then declines with a prevalence of VTE slightly higher than the general population after 12 weeks. However there is no prospective study of incidence of VTE in SCI patients after 3 months. The investigators wish to conduct such a study during the year following spinal cord…","s":"Terminated","tr":[],"o":["Breathing Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02796235"},{"n":"NCT03369080","t":"Prospective Survey of Body Mass Index in People With Spinal Cord Injury.","d":"This study is a prospective national survey of body mass index, and includes all patients with a new spinal cord injury hospitalized at Clinic for Spinal Cord Injuries, Rigshospitalet and Spinal Cord Injury Center of Western Denmark during a period of 9 months. Informed consent is retrieved from all participants.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03369080"},{"n":"NCT04418050","t":"Prosthetic Arthroplasties in Weight-bearing Shoulders","d":"Repeated transfers and wheelchair propulsion in patients with neurological deficit of the lower limbs leads to a major mechanical overload of the upper limbs, especially on shoulders, the \"weight-bearing\" shoulder. Under these conditions, arthroplasty is subject to significant constraints; such an indication in this condition is always discussed. The objective of this study was to evaluate the medium-term clinical and functional outcomes of anatomical and reverse arthroplasty on the…","s":"Completed","tr":["Devices","Observational"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04418050"},{"n":"NCT05249985","t":"Protein Supplementation and Neuromuscular Electrical Stimulation in Persons With SCI","d":"The aim of this pilot study is to explore how body composition, circulating markers of metabolic health and skin integrity in persons with a spinal cord injury (SCI) are affected by 12 weeks of quadriceps neuromuscular electrical stimulation (NMES) resistance training. The novel element of this study is that one group will be given additional daily protein supplementation in addition to the NMES training (treatment group), whereas the other group will only perform the NMES training (control…","s":"Completed","tr":["Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)","Nutrition","Rehabilitation"],"o":["Bone Strength"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05249985"},{"n":"NCT04699474","t":"Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury","d":"PROMPT-SCI (Protocol for Rapid Onset of Mobilization in Patients with Traumatic SCI) is a single-site single-arm proof-of-concept trial. Forty-five patients aged 18 years or older who have sustained a severe traumatic SCI (American Spinal Injury Association Impairment Scale grade A, B or C) from C0 to L1 and undergoing spinal surgery within 48 hours of the injury will be included. Participants will receive daily 30-minute sessions of in-bed leg cycling for 14 consecutive days, initiated within…","s":"Completed","tr":["Devices","Surgical Procedure"],"o":["Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04699474"},{"n":"NCT07472985","t":"Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial","d":"Spinal cord injuries (SCI) are among the most catastrophic survivable events experienced by human beings. Affected individuals remain with lifelong neurological impairment involving motor, sensory, bladder and bowel functions, which in turn impacts quality of life and independence. Currently, patients have no access to exercise therapy for weeks to months after the injury because clinicians remain fearful that early initiation of exercise therapy may be harmful to patients, and could lead to…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07472985","su":"https://scitrials.org/trial/NCT07472985"},{"n":"NCT07798310","t":"Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury III (PROMPT-SCI III) Trial","d":"This longitudinal cohort study will investigate the clinical benefits of early acute exercise therapy after mild spinal cord injury (SCI). The hypothesis is that early acute exercise therapy after mild SCI will improve neurofunctional recovery (walking, functional independence, motor and sensory recovery) and quality of life one year after the SCI, while decreasing complications during acute care and reducing the care burden (shorter hospital stay and home discharge more likely). For this…","s":"Not yet recruiting","tr":["Devices","Surgical Procedure"],"o":["Motor Function","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07798310"},{"n":"NCT01849822","t":"Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia","d":"This research study is being done to develop a brain controlled medical device, called a brain-machine interface or BMI, that will provide people with a spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts. Developing a brain-machine interface (BMI) is very difficult and currently only limited technology exists in this area of neuroscience. The device in this study involves implanting very fine recording electrodes into…","s":"Completed","tr":["Brain Machine Interface (BMI)","Devices","Drugs"],"o":["Arm Movement","Hand Movement"],"st":["California"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01849822"},{"n":"NCT00223860","t":"Provocative Testing Using LHRH and hCG of the Pituitary-Gonadal Axis in Persons With Spinal Cord Injury.","d":"There is evidence that has shown that serum testosterone levels are low in persons with chronic spinal cord injury (SCI). The question arises as to whether the defect in testosterone production is from the hypothalamic pituitary system (part of the brain that plays a role in testosterone release) or from the male testes. Studies to date are inconclusive. This study, will examine if persons with SCI has a normal hormonal regulation of the male hormone testosterone in comparison to persons who…","s":"Completed","tr":["Drugs"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00223860"},{"n":"NCT07251491","t":"Psilocybin to Treat Depression in Spinal Cord Injury","d":"The main goal of this study is to determine if psilocybin is safe for use in people with SCI. The study will measure how people with SCI respond to three psilocybin doses: low (5mg), medium (10mg), and high (25mg). The main question the study aims to answer is: does psilocybin increase the number and severity of adverse (bad) events reported by people with SCI? These may include pain, muscle spasms, symptoms of depression, and symptoms of low or high blood pressure. The investigators will also…","s":"Recruiting","tr":["Drugs"],"o":["Mental Health"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07251491","su":"https://scitrials.org/trial/NCT07251491"},{"n":"NCT04402398","t":"Psychometric Properties of a Mobile Application","d":"Current methods to assess superficial size and area of pressure ulcers are either time-consuming (using Transparency Tracings techniques), costly (computers, softwares), or necessitating to touch the patient's skin (using commun rulers). A free smartphone application (for IOS or Android) has recently been developed to measures skin lesions. It is called imitoMeasure. It does not require any contact with the patient. A photograph is taken with the smartphone, the limits of the lesion is then…","s":"Completed","tr":["Observational"],"o":["Hand Movement","Pressure Sores"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04402398"},{"n":"NCT03625193","t":"Psychometric Properties of Sit-to-stand Test in Spinal Cord Injury","d":"1. Do different arm placements (including arms on armrests/devices, arms on knees, arms free, and arm crossed over chest) influence outcomes of sit-to-stand test (STST) in ambulatory individuals with spinal cord injury (SCI)? 2. What are the factors associated with ability to perform STST in ambulatory individuals with SCI? 3. Are the single-time sit-to-stand test (STSST) and five-time sit-to-stand test (FTSST) reliable, valid and responsive to determine functional alteration in ambulatory…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Thailand"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03625193","su":"https://scitrials.org/trial/NCT03625193"},{"n":"NCT04007380","t":"Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI","d":"This clinical trial will examine the efficacy of continuous positive airway pressure (CPAP) therapy in improving psychosocial, neurocognitive and behavioral consequences of moderate-to-severe sleep-related breathing disorders (SRBDs) in people living with spinal cord injury (SCI).","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04007380","su":"https://scitrials.org/trial/NCT04007380"},{"n":"NCT03655080","t":"Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation After Cancer-Related Cord Compression","d":"The purpose of this research study is to look at a combination treatment of radiation therapy and a drug called Abraxane to treat epidural spinal cord compression.","s":"Terminated","tr":["Drugs","Epidural Stimulation"],"o":["Motor Function","Pain Management","Walking Function"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03655080"},{"n":"NCT04015362","t":"Pulsed Magnetic Stimulation - Managing Spasticity in Spinal Cord Injury","d":"Spasticity (tightening, spasming and/or contractions of muscles) is a commonly encountered consequence of injuries to the central nervous system. Spasticity has an adverse effect on quality of life and function of patients with spinal cord injuries, stroke and cerebral palsy. Conventional management consists of medication, injections of botulinum toxin and occasionally extensive surgical interventions. Several studies have examined the use of repetitive magnetic stimulation of the brain and of…","s":"Unknown","tr":["Brain Stimulation"],"o":["Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04015362","su":"https://scitrials.org/trial/NCT04015362"},{"n":"NCT05757830","t":"PURO - PUlmonary Rehabilitation With O-RAGT Platform","d":"The goal of this interventional study is to assess differences in the metabolic consumption, the cardiorespiratory effort, the cardiac autonomic adaptation, and fatigability during ADL, such as standing from a chair and walking while wearing an electrically powered exoskeleton in different modes of supports in subjects with neurological diseases with moderate to severe walking impairments.","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Breathing Function","Walking Function"],"st":[],"co":["Italy","Lithuania","Netherlands","Spain"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05757830"},{"n":"NCT04248322","t":"Qualitative Assessment of the Impact of TTNS on QOL and Participation","d":"This study through the use of semi-structured interviews or focus groups will explore the lived experience with Transcutaneous Tibial Nerve Stimulation (TTNS) with Neurogenic Lower Urinary Tract Dysfunction to generate user-defined themes regarding bladder function and catheter-related barriers and the daily impacts on one's life.","s":"Active, not recruiting","tr":["Devices","Observational","Transcutaneous Stimulation"],"o":["Bladder Function","Quality of Life"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04248322"},{"n":"NCT02894437","t":"Qualitative Study of Preventive Organization of the Pelvic Bedsores Injured Spinal Cord","d":"The purpose of the Protocol is the prevention of pelvic pressure ulcers within a care network of SCI patients whose general organization refers to the medical literature and the recommendations of the ministerial circular of 18 June 2004. A conceptual framework for work (CFW) will be set up and semi-structured interviews will be conducted with patients and professionals. They will confirm or dismiss the CFW gradually with a refined coding As of domains and sub-domains of the skin preventing…","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02894437"},{"n":"NCT03707704","t":"Quality Control of a Strengthening Protocol in Subjects With Spinal Cord Injury","d":"The aim of the master's thesis is to evaluate the clinic-internal strengthening concept of the Swiss Paraplegic Centre (SPZ). The SPZ is a rehabilitation clinic for spinal cord injured people. The strengthening concept has been routinely used since 2015. By default, the patients complete - depending on which training phase they are in - three to four strength training sessions per week. As part of the master's thesis, the development of maximum strength of patients with spinal cord injury (SCI)…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Bladder Function","Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03707704"},{"n":"NCT01573936","t":"Quality of Life in Adult Neurological Patients","d":"The purposes of this study were to evaluate the influence of an interdisciplinary rehabilitation program in the improvement of the health-related quality of life among adult neurological patients and to identify the sociodemographic and clinical associated characteristics. Subjects with spinal cord injury, acquired brain injury and poliomyelitis survivors participated in the study. All participants underwent a rehabilitation program (RP) from January 2008 through July 2010, which consists of…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01573936"},{"n":"NCT02412046","t":"Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics","d":"The aim of this study is to correlate the intensity and the duration of a mechanical strain, applied over the skin of a bedridden paraplegics, with the microvascularization parameters (oxygen saturation, blood flow and blood volume) and the early inflammatory mechanism. We want to detect the early stage of irreversible damage for each patient. To achieve this goal, we measure some specifics data over a group of 48 paraplegics admitted in the hospital for a pressure ulcer surgical treatment. The…","s":"Terminated","tr":["Devices","Surgical Procedure"],"o":["Pressure Sores"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02412046"},{"n":"NCT00472784","t":"Quantitative and Qualitative Changes in Neural Efferent Receptors","d":"OBJECTIVE: 1. To study tissues from spinal cord injured patients with noncompliant bladders as well as neurologically intact patients with normal bladder compliance, analyzing both quantitative and qualitative neural efferent receptors, collagen, and smooth muscle contents, using RT-PCR and electron microscopy. 2. To explore the possible shift in bladder neural architecture after SCI from beta to alpha-adrenergic receptors. RESEARCH DESIGN: 25 spinal cord injury patients who underwent…","s":"Withdrawn","tr":["Observational"],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00472784"},{"n":"NCT06583395","t":"Quest to Analyze One Thousand Humans Meditating","d":"This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and clinical populations.","s":"Enrolling by invitation","tr":["Observational"],"o":["Bone Strength","Bowel Function","Breathing Function","Mental Health","Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06583395"},{"n":"NCT04510974","t":"RAAS and Arterial Stiffness in SCI","d":"The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.","s":"Completed","tr":["Observational"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04510974"},{"n":"NCT00727584","t":"Radiation Therapy in Treating Patients With Metastatic Spinal Cord Compression","d":"RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy regimen is more effective in treating metastatic spinal cord compression. PURPOSE: This randomized clinical trial is comparing two radiation therapy regimens to see how well they work in treating patients with metastatic spinal cord compression.","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life","Walking Function"],"st":[],"co":["United Kingdom"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00727584"},{"n":"NCT07639541","t":"Radio-frequency (RF) Bladder Monitor","d":"The goal of this pilot feasibility study is to evaluate a wearable microwave (MW)-based bladder monitoring system in adult volunteers and those with spinal cord injury (SCI) who use self-catheterization for bladder management. The study aims to learn whether the device can monitor bladder filling and estimate bladder volume non-invasively. The main questions the study aims to answer are: 1. Can the MW-based monitoring system distinguish between non-full and full bladder states? 2. How…","s":"Not yet recruiting","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07639541","su":"https://scitrials.org/trial/NCT07639541"},{"n":"NCT06070233","t":"Radiosurgery Treatment for Spasticity Associated With Stroke, SCI & Cerebral Palsy","d":"A scientific study is being done to test a special treatment for people who have spasticity or tight muscles. This treatment is called \"stereotactic radiosurgery dorsal rhizotomy.\" It uses very accurate beams of radiation to target certain nerves in the back to help loosen up the muscles. In this study, people are put into two groups by chance: one group gets the real treatment, and the other group gets a \"fake\" treatment that doesn't do anything. This fake treatment is called a \"sham.\" Doing…","s":"Recruiting","tr":[],"o":["Spasticity"],"st":["Florida","Ohio"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06070233","su":"https://scitrials.org/trial/NCT06070233"},{"n":"NCT04043156","t":"RAdiotherapy for Metastatic Spinal Cord Compression with Increased Radiation DosES","d":"This clinical study aims to investigate whether high-precision radiotherapy, as supposed, leads to a better control of the irradiated spinal cord metastases when compared to conventional radiotherapy. This means that a progression or recurrence of motor deficits (weakness) of the legs following radiotherapy can be avoided more effectively. Furthermore, the high-precision radiotherapy will be compared to the conventional radiotherapy with respect to pain relief, motor function/ability to walk…","s":"Terminated","tr":[],"o":["Motor Function","Pain Management","Quality of Life","Sensory Function"],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04043156"},{"n":"NCT04777149","t":"Random Noise Stimulation to Enhance Cortical Drive & Improve Hand Function","d":"Cervical spinal cord injury (SCI) results in hand and arm function impairments and decreased independence in performance of daily activities such as bathing, eating, dressing, writing, or typing. Recent approaches that involve the application of non-invasive brain stimulation have the potential to strengthen the remaining connections between the brain and the spinal cord for improved hand function. Combining brain stimulation with performing upper limb functional tasks may further increase the…","s":"Completed","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04777149"},{"n":"NCT03170557","t":"Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation","d":"Pain is one of the most common problems in patients with spinal cord injury (SCI) and persistent pain (that can be of different origin: nociceptive, neuropathic or mixed) is often poorly responsive to pharmacological therapy. Attention has been paid to the use of non-pharmacological therapies and interventional techniques in treating pain in other clinical conditions, and acupuncture has been the treatment most used and appreciated for its effectiveness. However, only few studies are available…","s":"Terminated","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03170557"},{"n":"NCT04142814","t":"Randomized Controlled Study on T-PEP Versus IPV Method for Lower Respiratory Airways Clearance in Tetraplegic Tracheotomized Spinal Cord Injured Patients","d":"In tetraplegic patients with complete cervical spinal cord injury, respiratory complications are very frequent, especially in the sub-acute phase: the lungs often become obstructed due to the accumulation of secretions and the contemporary inefficiency of the cough mechanism. The present pilot study aims, in the context of a rehabilitative Critical Care Unit, at evaluating a not yet published method, called \"T-PEP\" and based on the principle of Positive Expiratory Pressure, applicable to…","s":"Withdrawn","tr":[],"o":["Breathing Function"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04142814"},{"n":"NCT03443700","t":"Randomized Controlled Trial on Robotic Exoskeleton in Spinal Cord Injury: Clinical Outcomes and Cortical Plasticity","d":"The recent introduction of robotics for locomotor training in paraplegic patients, and in particular the use of anthropomorphic exoskeletons, has opened new frontiers in rehabilitation. Existing literature, though encouraging, is still scarce and studies demonstrating efficacy are highly heterogeneous and have a small sample size. Evidence is also needed about cortical plasticity after SCI, in conjunction with the use of innovative rehabilitation devices, through indicators like…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Italy"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03443700","su":"https://scitrials.org/trial/NCT03443700"},{"n":"NCT00623376","t":"Randomized Double Blind Cross Over Study for Nabilone in Spasticity in Spinal Cord Injury Persons","d":"Objectives: To determine whether nabilone, a synthetic cannabinoid, alleviates spasticity in people with spinal cord injury (SCI). Methods: Twelve subjects were enrolled in this double-blind, placebo-controlled, crossover study. They received either nabilone or placebo during the first four-week period (0.5mg OD with option to increase to 0.5mg BID), then outcome measures were assessed. After a two-week washout, subjects were crossed-over to the opposite arm. The primary outcome was the…","s":"Completed","tr":["Drugs"],"o":["Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00623376"},{"n":"NCT02878850","t":"Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury","d":"The purpose of this study is to learn more about how participants heal from acute spinal cord injury.","s":"Completed","tr":[],"o":["Blood Pressure","Motor Function","Pain Management","Quality of Life","Sensory Function"],"st":["California","Connecticut","Kansas","Maryland","North Carolina","Ohio","Oregon","Pennsylvania"],"co":["United States"],"lc":11,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02878850"},{"n":"NCT01633164","t":"Re-Inventing Yourself After Spinal Cord Injury","d":"The purpose of this study is to evaluate the efficacy of a replicable, psychologically-based group education intervention, Re-Inventing Yourself after Spinal Cord Injury (SCI), which aims to enhance personal self-efficacy. A structured six-week, manualized, group therapy intervention that delivers positive psychology concepts within a cognitive-behavioral therapy-based model has been created for the purpose of developing a resilient and optimistic sense of efficacy for people with SCI. Concepts…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01633164"},{"n":"NCT02960178","t":"Reactive Stepping Training in Individuals With Spinal Cord Injury","d":"Falling is common among individuals with incomplete spinal cord injury (iSCI), with most falls occurring while walking. Falls result in injuries (e.g., broken bones), hospital readmission, and reduced participation in work and recreation. In able-bodied people, falls can be prevented by taking one or more rapid, reactive steps. People with iSCI, however, have difficulty taking the reactive steps needed to prevent a fall. Research in the elderly and people with stroke has shown that repetitive…","s":"Completed","tr":[],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02960178"},{"n":"NCT01997125","t":"Reanimation in Tetraplegia","d":"The purpose of this clinical study is to allow the investigation of the Neural Bridging System for participants with tetraplegia to assess if the investigational device can reanimate a paralyzed limb under voluntary control by the participant's thoughts.","s":"Completed","tr":["Devices"],"o":["Motor Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01997125"},{"n":"NCT06440538","t":"Rebuilding Inter-limb Transfer in Cervical SCI","d":"The purpose of this study in people living with cervical Spinal Cord Injury (SCI) is to examine the effects of paired neurostimulation (i.e., PCMS) combined with contralateral motor training on inter-limb transfer of ballistic motor and hand dexterity skills.","s":"Active, not recruiting","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06440538","su":"https://scitrials.org/trial/NCT06440538"},{"n":"NCT05985031","t":"Reciprocal Inhibition Versus Reciprocal Facilitation In Spinal Cord Injury Patients","d":"Reciprocal inhibition is a medulla spinalis control mechanism that facilitates motor activities in healthy people. As the agonist muscle contracts, the antagonist muscle is inhibited so that the agonist action can take place properly. In the literature, there are studies showing that in patients with upper motor neuron lesions, this reverses, and reciprocal facilitation occurs instead of inhibition. However, there is no clear situation in this regard, there is a need for more methodologically…","s":"Completed","tr":[],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05985031"},{"n":"NCT02227407","t":"Reciprocating Gait Orthoses for Paraplegia Patients","d":"Ambulation would bring many physiological and psychological benefits and getting up and walking has been a dream for paraplegia patients.The reciprocating gait orthoses (RGOs) for paraplegics particularly draws research attentions because it mimics human gait pattern.But, the high energy consumption and low walking speeds caused the frequent abandonment or the low utilization of the reciprocating gait orthoses.To improve the design reducing the energy expenditure, it requires biomechanical…","s":"Unknown","tr":["Devices"],"o":["Walking Function"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02227407","su":"https://scitrials.org/trial/NCT02227407"},{"n":"NCT07237035","t":"Reclaiming Independence: Daily Activities and Rehabilitation Goals in Spinal Cord Injury","d":"The purpose of this cross-sectional, observational survey was to assess the importance individuals with Spinal Cord Injury (SCI) in Türkiye place on specific Activities of Daily Living (ADL) and their target levels of independence for these activities after rehabilitation. The primary question it aims to answer is: What are the functional priorities of individuals with SCI (e.g., eating, bathing, walking, wheelchair use), and what are their personal goals for independence in these activities?…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07237035"},{"n":"NCT04193709","t":"Recovery of Bladder and Sexual Function After Human Spinal Cord Injury","d":"This study will incorporate critical cross viscero-visceral intersystem interactions to 1) investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2) to regulate cardiovascular function therapeutically…","s":"Completed","tr":["Epidural Stimulation"],"o":["Bladder Function","Blood Pressure","Bowel Function","Sensory Function","Sexual Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04193709"},{"n":"NCT03036527","t":"Recovery of Bladder and Sexual Function After Spinal Cord Injury","d":"Bladder and sexual dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury. The insights of how activity-based training affects bladder function may prove to be useful to other patient populations with bladder and sexual dysfunction such as multiple sclerosis, Parkinson's, and stroke, as well as stimulate investigations of training's effects within other systems such as bowel dysfunction. Locomotor training could help promote functional…","s":"Completed","tr":["Epidural Stimulation","Rehabilitation"],"o":["Bladder Function","Bowel Function","Quality of Life","Sexual Function","Walking Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03036527"},{"n":"NCT02037620","t":"Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury","d":"We propose to demonstrate that epidural stimulation (ES) can be used to recover significant levels of autonomic control of cardiovascular and respiratory function as well as the ability to voluntarily control leg movements below the injury level. This intervention would provide an immediate therapeutic alternative to individuals who now have no recourse for treatment.","s":"Completed","tr":["Epidural Stimulation"],"o":["Blood Pressure","Breathing Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02037620"},{"n":"NCT02799966","t":"Recovery of Upper Limb Function in Persons With Spinal Cord Injury: Lead-In Study","d":"Many individuals with cervical spinal cord injury (SCI) have difficulty using their hands and arms. MyndMove is a non-invasive medical device that uses short, low energy electrical pulses with surface electrodes to cause muscle contractions to produce a full range of reaching and grasping movements, which the patient is unable to perform by him/herself. By using MyndMove therapy to help the individual move their arms and hands as he/she attempts to carry out typical reaching and grasping…","s":"Terminated","tr":["Devices"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Canada"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02799966"},{"n":"NCT04237363","t":"Recovery of Walking in Persons With Complete Spinal Cord Injury","d":"We documented the impact of 1 year of underwater treadmill training and supplemental overground walk training in five adults with chronic motor-complete SCI (cSCI) who had not undergone programmed epidural spinal cord stimulation (eSCS).","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Rehabilitation"],"o":["Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04237363"},{"n":"NCT04074616","t":"Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation","d":"The purpose of this study is to determine the efficacy of home transcutaneous tibial nerve stimulation (TTNS) in spinal cord injury(SCI) and to determine the impact on quality of life using TTNS at home","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04074616"},{"n":"NCT03906721","t":"Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation","d":"The use of conditioning open-label placebo (COLP) will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid dose to diminish adverse effects as well as the risk of addiction associated with narcotic treatment.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Pain Management","Quality of Life"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03906721"},{"n":"NCT01297673","t":"Reflux in Spinal Cord Injury Patients With Neurogenic Lower Urinary Tract Dysfunction","d":"The purpose of this study is to investigate the incidence of reflux in patients with spinal cord injury in relation to the lesion level, duration of injury and bladder management","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01297673"},{"n":"NCT07140354","t":"Regain of Arm and Hand Movements in Cervical Spinal Stimulation","d":"We will develop a \"bottom to top\" approach employing animal models and human testing to determine whether or not non-invasive neuro-modulation of the cervical spinal cord concomitant with upper limb rehabilitation driven by exo-skeletons can facilitate the regain of the arm and hand functional movements in spinal cord injured patients. We hypothesize that that spinal electrical neuro-modulation together with sensory-motor rehabilitation will facilitate the transmission and processing of the…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Breathing Function","Hand Movement","Motor Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07140354"},{"n":"NCT04041063","t":"Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury","d":"The aim of this study is to determine the effects of rehabilitation on dexterous hand movements and cortical motor map changes in tetraplegic patients following nerve transfer surgery. The working hypothesis is that robot-assisted, intensive rehabilitation will support the return of hand and arm function and strengthen the cortical representations of targeted muscles. The investigators will assess this through TMS mapping and clinical measures of hand and arm function.","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04041063","su":"https://scitrials.org/trial/NCT04041063"},{"n":"NCT06881134","t":"Rehabilitation Combining Spatiotemporal Spinal Cord Stimulation and Real-time Triggering Exoskeleton After Spinal Cord Injury","d":"Spinal cord injury (SCI) can be caused by trauma, inflammation, tumors, and other factors, often leading to issues such as impaired leg movement, abnormal sensation, and difficulties with bladder and bowel control. These challenges significantly affect the patient's quality of life. While there is currently no cure for spinal cord injury, the latest guidelines recommend spinal cord stimulation and robotic exoskeletons as effective rehabilitation methods. Spinal cord stimulation (SCS) involves…","s":"Completed","tr":["Devices","Electrical Stimulation","Exoskeleton","Rehabilitation"],"o":["Bladder Function","Bowel Function","Leg Movement","Motor Function","Pain Management","Quality of Life","Sensory Function","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06881134"},{"n":"NCT00833105","t":"Rehabilitation of the Upper Extremity With Enhanced Proprioceptive Feedback Following Incomplete Spinal Cord Injury","d":"The purpose of this study is to determine if tetraplegic individuals with incomplete spinal cord injury (SCI) who remain unable to move their arms normally 1 year after their SCIs are able to sense and move the affected arm(s) better after 10-13 weeks of treatment with a new robotic therapy device. The hypothesis is that using the AMES device on the arm(s) of chronic tetraplegic subjects with incomplete SCI will result in improved strength, sensation, and functional movement in treated limb(s).","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Sensory Function","Spasticity"],"st":["Georgia","Oregon"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00833105"},{"n":"NCT07008157","t":"Rehabilitation Program for Bladder Control in Individuals With Incomplete Spinal Cord Injury","d":"This prospective, randomized, double-blind clinical trial (with both participants and outcome assessors blinded to group assignments) was carried out at the outpatient clinic of the Faculty of Physical Therapy, Cairo University, following patient referrals. Participants were recruited between October 2024 and April 2025 from the National Institute of Urology and Nephrology in Mataria, as well as the Department of Urology and Nephrology at Kasr Alaini Hospital. All diagnoses were verified by a…","s":"Completed","tr":["Rehabilitation"],"o":["Bladder Function"],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07008157"},{"n":"NCT03390140","t":"ReInventing Yourself After SCI: an Intervention to Improve Outcomes After Spinal Cord Injury","d":"The primary goal of this study is to conduct a multi-site RCT to evaluate the replicability and efficacy of the ReInventing Yourself after SCI intervention in improving health and function outcomes for persons with spinal cord injury (SCI). A total of 252 participants will be randomized to one of three research arms: 1) Group treatment plus workbook (Group), 2) individual self-study through YouTube video plus workbook (Indiv), and 3) no treatment, no workbook (Control). Participants randomized…","s":"Unknown","tr":[],"o":["Mental Health"],"st":["Colorado","Michigan","New Jersey"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03390140","su":"https://scitrials.org/trial/NCT03390140"},{"n":"NCT04949763","t":"Reliability and Validity of the ISNCSCI in Patients With Non-traumatic Spinal Cord Lesions","d":"Aim of the study is to assess the psychometric properties of the International Standards for Neurological Classification of Spinal Cord Injury in subjects with non traumatic lesions.","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04949763"},{"n":"NCT07280923","t":"Reliability and Validity of the PReFS","d":"This study is testing the psychometric properties of a new tool to determine recommendations for pressure relief frequency in wheelchair users.","s":"Recruiting","tr":["Devices"],"o":["Pressure Sores"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07280923","su":"https://scitrials.org/trial/NCT07280923"},{"n":"NCT05935943","t":"Reliability and Validity of the Spinal Cord Injury Secondary Conditions Scale","d":"People living with spinal cord injury (SCI) experience a range of secondary health conditions that impact their quality of lives. The Spinal Cord Injury Secondary Conditions Scale (SCI-SCS) is a 16-item questionnaire that assess secondary health conditions in persons with SCI. The total score of SCI-SCS range from 0 to 48 and is derived by adding the scores for each item. Higher scores indicate greater problems with secondary conditions. The investigators aimed to determine the reliability and…","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05935943"},{"n":"NCT06990243","t":"Reliability and Validity of the Turkish Version of the SCIPI","d":"Pain after spinal cord injury (SCI) is common, with the majority of individuals experiencing chronic pain and a significant portion reporting severe pain that interferes with their daily lives. Pain due to SCI is divided into two main groups: nociceptive and neuropathic. Clinical expertise is required for the accurate classification of these types of pain. Existing screening tools are generally evaluated with heterogeneous samples and therefore have limited accuracy in individuals with SCI. To…","s":"Not yet recruiting","tr":["Observational"],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06990243","su":"https://scitrials.org/trial/NCT06990243"},{"n":"NCT07488793","t":"Remote Ischemic Conditioning for PwSCI","d":"The long-term goal of this project is to improve the overall cardiometabolic health of persons with spinal cord injury (SCI). This pilot study will test the feasibility and acceptability of remote ischemic conditioning implemented in a home setting by persons with SCI and collect cardiometabolic health outcomes to inform appropriate outcomes for a future larger trial. Researchers will compare, RIC high dose using standard blood pressure cuff to RIC high dose using automated blood flow…","s":"Recruiting","tr":["Rehabilitation"],"o":["Quality of Life"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07488793","su":"https://scitrials.org/trial/NCT07488793"},{"n":"NCT03499951","t":"Remote Wheelchair Skills Training Efficacy","d":"The objective of the study is to evaluate the effectiveness of remote training to teach clinicians how to train others in wheelchair skills.","s":"Completed","tr":[],"o":[],"st":["Florida","Illinois","New Jersey","Pennsylvania"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03499951"},{"n":"NCT05870189","t":"Remotely Delivered Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery After Spinal Cord Injury","d":"So far, therapies have limited success in functional recovery in adults with chronic SCI. By introducing remote cognitive multisensory rehabilitation (CMR), which has shown significant functional improvements due to neurological recovery when delivered in-person, transformative results that (i) provide a potentially effective new therapy within the healthcare system, accessible to more patients, and (ii) demonstrate brain function changes alongside improved function in chronic SCI are…","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05870189"},{"n":"NCT02481440","t":"Repeated Subarachnoid Administrations of hUC-MSCs in Treating SCI","d":"The purpose of this study is to evaluate the safety and efficacy of repeated intrathecal administrations of allogeneic human umbilical cord mesenchymal stem cells for the treatment of spinal cord injury.","s":"Completed","tr":["Stem Cells"],"o":["Bowel Function","Spasticity"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02481440"},{"n":"NCT03433599","t":"Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair","d":"Our goal is to enhance repeated exposure to acute intermittent hypoxia (rAIH)/training-induced aftereffects on upper and lower limb function recovery in humans with chronic spinal cord injury (SCI).","s":"Unknown","tr":["Intermittent Hypoxia"],"o":["Arm Movement","Hand Movement"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03433599","su":"https://scitrials.org/trial/NCT03433599"},{"n":"NCT02351921","t":"Repetitive Transcranial Magnetic Stimulation in Individuals With Spinal Cord Injury: A Pilot Study","d":"This study will investigate how repetitive transcranial magnetic stimulation delivered as a protocol called 'continuous theta-burst stimulation (cTBS)' alters motor output and force control to a muscle in the forearm and touch perception in individuals with chronic, incomplete spinal cord injury. CTBS is a non-invasive technique that involved repetitive delivery of transcranial magnetic stimulation at a frequency of 30 Hz over the arm representation in the primary motor or sensory cortex. The…","s":"Completed","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Motor Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02351921"},{"n":"NCT06726954","t":"Repetitive Transcranial Magnetic Stimulation Therapy in Spinal Cord Injury Related Neuropathic Pain","d":"The aim of our study is to investigate the effect of different protocols of high-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) therapy added to the rehabilitation program on neuropathic pain,depression, quality of life and quality of sleep compared to each other and placebo group in participants with spinal cord injury.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Pain Management"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06726954","su":"https://scitrials.org/trial/NCT06726954"},{"n":"NCT05333770","t":"Repetitive Transcranial Magnetic Stimulation to Promote Regeneration in Persons With SCI","d":"This is a research study to evaluate the safety, efficacy and feasibility of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in patients with subacute spinal cord injury.","s":"Unknown","tr":["Brain Stimulation"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05333770","su":"https://scitrials.org/trial/NCT05333770"},{"n":"NCT02138201","t":"Representation of the Bladder Innervation Using Diffusion Tensor Imaging Fiber Tracking With MRI - a Pilot Study","d":"The exact innervation of the bladder and the changes after a spinal cord injury have been not yet been illustrated. Diffusion tensor imaging with magnetic resonance imaging is a new technique which can be used to visualize single nerve fibers, and thus represent the neural supply of a region in vivo. There are studies in which both the sacral plexus and the lumbar nerve roots have been represented using diffusion tensor imaging. However, there is no study concerning the innervation of the…","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02138201"},{"n":"NCT06829212","t":"Research on Wireless Brain Implant System for General Control of External Devices","d":"The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive technologies, for paralyzed and amputee patients. WRS integrates a high-throughput, ultra-flexible neural electrode with an extremely small cross-sectional size-approximately one-hundredth the diameter of a human hair. Moreover, the implantable component is fully embedded…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06829212","su":"https://scitrials.org/trial/NCT06829212"},{"n":"NCT04544761","t":"Resilience in Persons Following Spinal Cord Injury","d":"This study aims to quantify resilience in survivors of a spinal cord injury. The study will consist of structured interviews and self-reported surveys. We will look for common themes between participants at different stages of injury (1-5 years, 5-15 years, \\>15 Years).","s":"Completed","tr":["Observational"],"o":["Mental Health"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04544761"},{"n":"NCT01652040","t":"Resistance Training and Testosterone After Spinal Cord Injury","d":"The goal of this proposal is to investigate the efficacy of a complimentary approach of evoked resistance training and testosterone replacement therapy on the changes in body composition and metabolic profile after SCI. The proposed method could become a recommended and simple intervention especially for individuals with limited access and poor tolerance to exercise. The rationale is based on the evidence that individuals with SCI experience decline in anabolic hormones which may be responsible…","s":"Completed","tr":["Devices","Drugs","Rehabilitation"],"o":["Blood Pressure"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01652040"},{"n":"NCT03949699","t":"Resistance Training to Improve Strength and Functional Trunk Stability in Adults With Paraplegia","d":"The purpose of this study is to examine the effectiveness of an 8- week resistance training routine to improve functional trunk strength, muscle activation, and physical functioning in exercise in 30 adults with paraplegic SCI. This study will also examine outcomes of confidence in one's ability to avoid falling during balance challenges, and self-efficacy for participating in exercise activity.","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function","Trunk Control"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03949699"},{"n":"NCT01957358","t":"Resolving Grief After Spinal Cord Injury","d":"The purpose of this study is to examine the usefulness of the Grief Recovery Method in assisting persons with spinal cord injuries to achieve as complete a recovery as possible, thereby allowing for fuller participation in life.","s":"Unknown","tr":["Rehabilitation"],"o":["Mental Health"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01957358","su":"https://scitrials.org/trial/NCT01957358"},{"n":"NCT04114604","t":"Respiratory Capacity and Swallowing Function in Spinal Disorders: A Pilot Study","d":"This study is part of a larger grant, for which the overall goal is to collect measurements of liquid flow through the oropharynx (i.e., mouth and throat) during swallowing.The focus of this study is to evaluate the flow of liquids of varying consistency in the spinal disorder population.","s":"Completed","tr":["Observational"],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04114604"},{"n":"NCT02163551","t":"Respiratory Event-Related Potentials in Patients With Spinal Cord Injury","d":"Dyspnea is \"a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity\". It is known that sensory information from the respiratory system activates regions of the cerebral cortex to produce the perception of dyspnea but far less is known about the neurophysiology of dyspnea than about vision, hearing, or even pain. Dyspnea likely arises from multiple nervous system sources, but the exact locations have not been well identified…","s":"Terminated","tr":["Observational"],"o":["Breathing Function","Pain Management"],"st":["North Carolina"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02163551"},{"n":"NCT02396823","t":"Respiratory Motor Control and Blood Pressure Regulation After Spinal Cord Injury","d":"The proposed study is designed to answer a novel research question: Can resistive respiratory muscle training designed to improve respiratory motor control also improve blood pressure regulation impaired by spinal cord injury? Resistive breathing exercise, or respiratory muscle training, has been applied to rehabilitate breathing after spinal cord injury, but has not been evaluated as a method for increasing resting blood pressure and / or improving its regulation under stress as is planned in…","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Motor Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02396823"},{"n":"NCT05904600","t":"Respiratory Muscle Training in Adults With Spinal Cord Injury","d":"The purpose of this study is to investigate the effectiveness of a programme based on inspiratory and expiratory muscle training to improve respiratory muscle strength, functional capacity and avoid pulmonary complications in adults with cervical or high dorsal spinal cord injury (C5-D5) in acute phase.","s":"Unknown","tr":[],"o":["Breathing Function"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05904600","su":"https://scitrials.org/trial/NCT05904600"},{"n":"NCT00629850","t":"Respiratory Resistance Training on Sleep Quality in Persons With Spinal Cord Injury","d":"The purpose of this study is to determine if the use of a respiratory resistance trainer will increase respiratory muscle strength, improve sleep quality and improve quality of life in individuals with spinal cord injury. Hypothesis: Use of the respiratory resistance trainer will improve respiratory muscle strength, improve sleep quality, and improve quality of life among individuals with spinal cord injury.","s":"Terminated","tr":["Devices","Rehabilitation"],"o":["Breathing Function","Motor Function","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00629850"},{"n":"NCT04102826","t":"Restoration of Arm Function in People With High-level Tetraplegia","d":"Functional electrical stimulation (FES) has been used to activate paralysed muscles and restore movement after spinal cord injury and stroke. This technology involves the application of low-level electrical currents to the nerves and muscles to cause muscle contraction where the user's ability to achieve that through voluntary means has been lost. Providing control of muscle contraction in a coordinated way can mean that users are able once again to produce functional movements in otherwise…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Hand Movement","Leg Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04102826"},{"n":"NCT05968352","t":"Restoration of Bladder Function in Spinal Cord Injury","d":"The aim of this study is to develop improved methods of restoring function to the neurogenic bladder, using electrical stimulation without cutting nerves in patients with spinal cord injury. The investigators will test 5-10 subjects with existing sacral anterior root stimulation (SARS) devices and look at the effects of high frequency (up to 600Hz) compared to the usual low frequency stimulation on bladder function. The investigators are particularly interested in whether it is possible to…","s":"Withdrawn","tr":["Electrical Stimulation","Observational"],"o":["Bladder Function"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05968352"},{"n":"NCT06611748","t":"Restoration of Hand Function in Cervical SCI","d":"The purpose of this study is to evaluate a new method of restoring hand function to people with spinal cord injury. Current methods to restore hand function include tendon transfers and nerve transfers. This study will evaluate the grasp strength that can be achieved with a small, implantable stimulator. KeyGrip is an investigational device that works by activating paralyzed muscles with low levels of electrical current. The word \"investigational\" means the study device is still being tested in…","s":"Recruiting","tr":[],"o":["Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06611748","su":"https://scitrials.org/trial/NCT06611748"},{"n":"NCT03439319","t":"Restoration of Reaching and Grasping Function in Individuals With Spinal Cord Injury Using MyndMove® Neuromodulation Therapy","d":"A two-arm, parallel group, multicentre, single-blind, randomized controlled trial comparing electrical neuromodulation delivered by MyndMove® therapy to intensive upper-limb conventional therapy in the treatment of patients with moderate to severe motor impairment to their arms and hands from an incomplete, traumatic spinal cord injury.","s":"Completed","tr":["Electrical Stimulation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Ohio","Texas"],"co":["Canada","United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03439319"},{"n":"NCT02899858","t":"Restoration of Standing and Walking With ISMS in Humans","d":"Spinal cord neural circuitry exists in the lumbar enlargement that makes it possible to stand and create synergistic, rhythmic stepping activity in the lower limbs. In the past 20 years, clinicians have tried to reengage such these circuits for standing and walking in the lower spinal cord of paralyzed humans through novel paradigms of physical therapy, pharmacological stimulation of the spinal cord, or recently - epidural stimulation of the spinal cord. Although standing and stepping with…","s":"Withdrawn","tr":["Epidural Stimulation","Rehabilitation"],"o":["Leg Movement","Walking Function"],"st":["Tennessee"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02899858"},{"n":"NCT01292811","t":"Restoration of Upper Limb Function in Individuals With Sub-Acute Spinal Cord Injury","d":"The objective of this research program is to conduct a multi-site clinical randomized control trial that will evaluate the efficacy of functional electrical stimulation based upper limb intervention for people with tetraplegia. This will involve recruiting 84 persons with sub-acute tetraplegia across four sites (Montreal,Toronto, Fredericton and Edmonton) and will serve to evaluate three new Canadian hand function assessments that have been specifically developed for persons with tetraplegia…","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01292811"},{"n":"NCT04171375","t":"Restorative Neuromodulation for Lower Extremity Functions","d":"The overall objective of the proposed study is to restore lower-extremity functions of paraplegic individuals. Paralysis following Stroke or spinal cord injury (SCI) result harsh sufferings including lifelong dependence on wheelchairs and thus often life threatening conditions such as pressure sore resulted from the immobility. Recently, electrical stimulation targeting the lumbosacral spinal cord has shown activation of spinal circuits that control standing and walking functions; while…","s":"Completed","tr":["Devices","Electrical Stimulation","Rehabilitation"],"o":["Leg Movement","Pressure Sores","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04171375"},{"n":"NCT04183998","t":"Restorative Neuromodulation for Upper Extremity Functions","d":"The objective of this research study is to find the efficacy of trans-spinal electrical stimulation, a non-invasive neurostimulation method to modulate the functions of spinal cord neurocircuits, on improving upper-extremity functions such as reaching and grasping in individuals suffering with traumatic brain injury (TBI) or cervical spinal cord injury (SCI); and to find the physiological changes in the neuromuscular systems after this new intervention with high-resolution electrophysiology and…","s":"Completed","tr":["Electrical Stimulation"],"o":["Arm Movement","Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04183998"},{"n":"NCT05644171","t":"RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation","d":"Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients. The NNI Neurosurgery team, together with our collaborators, are expanding our recruitment from our pilot trial named RESTORES: RESToration of Rehabilitative function with Epidural Spinal Stimulation. This study aims to investigate the feasibility of electrical stimulation via a spinal cord stimulator (SCS), which will be implanted…","s":"Recruiting","tr":["Epidural Stimulation"],"o":[],"st":[],"co":["Singapore"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05644171","su":"https://scitrials.org/trial/NCT05644171"},{"n":"NCT01906424","t":"Restoring Arm and Hand Function With Non-invasive Spinal Stimulation","d":"This study is to determine if non-invasive electrical stimulation of the spinal cord can help improve hand and arm function in people with paralysis who suffered a cervical spinal cord injury.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["California"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01906424"},{"n":"NCT03451474","t":"Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries","d":"The primary objective of this study is to evaluate the safety and efficacy of nerve transfer surgery for restoring hand function as a therapy for patients with cervical spinal cord injury.","s":"Terminated","tr":["Surgical Procedure"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Sensory Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03451474"},{"n":"NCT04994886","t":"Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury","d":"The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in patients with chronic cervical or high-thoracic spinal cord injury. The ultimate objective of this feasibility study is to provide preliminary safety and efficacy measures on the ability of the hemodynamic Targeted Epidural Spinal Stimulation (TESS) to ensure the long-term management of hemodynamic instability and reduce the…","s":"Terminated","tr":["Devices","Electrical Stimulation","Epidural Stimulation","Surgical Procedure"],"o":["Blood Pressure","Breathing Function","Quality of Life","Spasticity","Trunk Control"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04994886"},{"n":"NCT05044923","t":"Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury","d":"The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in participants with chronic cervical or high-thoracic spinal cord injury. The ultimate objective of this study is to provide preliminary safety and efficacy measures on the ability of the hemodynamic Targeted Epidural Spinal Stimulation (TESS) to ensure the long-term management of hemodynamic instability and reduce the incidence and…","s":"Unknown","tr":["Epidural Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05044923","su":"https://scitrials.org/trial/NCT05044923"},{"n":"NCT03482310","t":"Restoring High Dimensional Hand Function to Persons With Chronic High Tetraplegia","d":"This study is for people who have a paralyzed arm and hand from a spinal cord injury, who have also received a recording electrode array in the brain as part of the BrainGate study. The study will look at the ability of these participants to control different grasping patterns of the hand, both in virtual reality and in his/her actual hand. Movement of the participant's hand is controlled by a functional electrical stimulation (FES) system, which involves small electrodes implanted in the arm…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03482310"},{"n":"NCT03680872","t":"Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System","d":"This is a single-cohort early feasibility trial to determine whether an investigational device called the Bidirectional Neural Bypass System can lead to the restoration of movement and sensation in the hand and wrist of up to seven individuals with tetraplegia.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03680872","su":"https://scitrials.org/trial/NCT03680872"},{"n":"NCT04262414","t":"Restoring Upright Mobility After Spinal Cord Injury","d":"Up to 15 able-bodied individuals will participate in one testing session to evaluate the effectiveness of the A-FES system. Up to 20 individuals with SCI will participate in 12 sessions of A-FES therapy. At each session, participants will stand on a force plate (Accu Sway, AMTI, USA) with the A-FES system (Compex Motion II, Compex Motion, Switzerland) donned. The centre of pressure (COP) will be calculated in real time using the force plate data. The calculated COP will be presented to…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Trunk Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04262414"},{"n":"NCT00488280","t":"Restoring Walking in Non-ambulatory Children With Severe Chronic Spinal Cord Injury (SCI) (Kids STEP Study)","d":"The Kids STEP Study aims to 1. Determine if walking can be restored in children with incomplete SCI and little to no leg movement 2. Identify the neural pathways that permit recovery of walking","s":"Completed","tr":["Observational","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Motor Function","Quality of Life","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00488280"},{"n":"NCT02322125","t":"Restoring Walking With a Powered Exoskeleton After Spinal Cord Injury","d":"Powered exoskeletons have emerged recently, promising to offer walking to individuals with severe spinal cord injury who are unable to walk. We will use the ReWalk exoskeleton to train walking in individuals with chronic, severe spinal cord injury (SCI). We will determine the characteristics of individuals who most benefit from such training, and identify the neuroplasticity induced by the training. We will further determine the feasibility of the ReWalk for home and community ambulation.","s":"Completed","tr":["Exoskeleton"],"o":["Pain Management","Plasticity","Spasticity","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02322125"},{"n":"NCT04967274","t":"Reticulospinal Control of Movements","d":"Accurate movement execution is a result of a complex interplay between various muscle groups whose activity is controlled by different areas of the central nervous system. Besides the corticospinal system, the phylogenetically old reticulospinal system is a key motor system controlling different elementary movements including posture, locomotion and reaching across all mammals. In contrast to the extensively investigated corticospinal system, there is only sparse knowledge on the motor…","s":"Recruiting","tr":["Rehabilitation"],"o":["Hand Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04967274","su":"https://scitrials.org/trial/NCT04967274"},{"n":"NCT00059553","t":"Retraining Walking After Spinal Cord Injury","d":"Incomplete spinal cord injury often results in difficulty walking. Training on a treadmill with body weight support may improve walking ability after spinal cord injury. The purpose of this study is to examine the effect of treadmill speed on spinal cord function and walking performance.","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00059553","su":"https://scitrials.org/trial/NCT00059553"},{"n":"NCT05575674","t":"Retrospective Study on Myoelectric Elbow-Wrist-Hand Orthosis User Outcomes","d":"The objective of this study is to retrospectively evaluate the outcomes and clinical benefits provided by this brace to adult patients with upper limb impairment or paralysis due to brachial plexus, stroke (CVA), spinal cord injury, or other neurological disease or injury.","s":"Completed","tr":["Devices","Observational"],"o":["Arm Movement"],"st":["Massachusetts","Ohio","Washington"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05575674"},{"n":"NCT06740006","t":"Retrospective Study on the WalkOn AFO in Children or Teenagers With Neurological Pathologies","d":"The goal of this observational study is to assess the interest of prefabricated carbon fiber ankle foot orthoses (AFO) in children and teenagers with central or peripheral neurological pathologies. The main question it aims to answer is: Does prefabricated carbon AFO improve gait and provide user satisfaction? In current practice, all patients with gait impairments were fitted with this orthosis and had a 3D gait analysis with and without AFO. Biomecanical and follow-up data collected in…","s":"Completed","tr":["Devices","Observational"],"o":["Spasticity","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06740006"},{"n":"NCT02944669","t":"ReWalk Personal Device Postmarket Study","d":"This study seeks to further evaluate the Multi-Tiered Training Program and to further explore the overall safety profile of the ReWalk Personal Device outside of the institutional setting under conditions of routine medical practice.","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":["California","Indiana"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT02944669","su":"https://scitrials.org/trial/NCT02944669"},{"n":"NCT01597518","t":"Riluzole in Spinal Cord Injury Study","d":"The aim of this study is to evaluate efficacy and safety of riluzole in the treatment of patients with acute SCI. The primary objective is to evaluate the superiority of riluzole, at a dose of 2 x 100 mg the first 24 hours followed by 2 x 50 mg for the following 13 days after injury, as compared to placebo, in change between 180 days and baseline in motor outcomes as measured by International Standards for Neurological Classification of Spinal Cord Injury Examination (ISNCSCI) Motor Score, in…","s":"Terminated","tr":["Drugs"],"o":["Motor Function","Quality of Life"],"st":["Arizona","California","Florida","Georgia","Kansas","Kentucky","Louisiana","Maryland","Minnesota","Missouri","Pennsylvania","Texas","Utah","Virginia","Washington","Wisconsin"],"co":["Australia","Canada","United States"],"lc":29,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01597518"},{"n":"NCT02859792","t":"Riluzole in the Treatment of Spasticity in the Traumatic Chronic Spinal Cord Injury Condition","d":"The study will be conducted in two steps: 1. Determination of the Minimal Effective Dose (MED) among the four doses of the panel 2. Estimation of the probability of response associated to the MED. Each step has a main objective: Step 1 Objective: To determine a daily dose of Riluzole that improves spasticity in patients with chronic SCI Step 2 Objective: To demonstrate, in a phase 2b trial, the efficacy of Riluzole to improve spasticity vs placebo, in patients with chronic SCI.","s":"Unknown","tr":[],"o":["Spasticity"],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02859792","su":"https://scitrials.org/trial/NCT02859792"},{"n":"NCT00150696","t":"Risedronate for the Prevention of Osteoporosis in People With Spinal Cord Injury.","d":"The purpose of this study is to find out if Risedronate works to prevent osteoporosis after spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bone Strength","Quality of Life"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00150696"},{"n":"NCT00138866","t":"Risedronate for the Treatment of Osteoporosis for People With Spinal Cord Injury","d":"The purpose of this study is to find out if risedronate works for the treatment of osteoporosis for people with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Bone Strength"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00138866"},{"n":"NCT04243161","t":"RMT in Patients With Spinal Cord Injury","d":"Spinal Cord Injury (SCI) is an involvement of the spinal cord, a nerve cord protected by the spine and extends from the base of the brain to the lumbar region. The spinal cord lesion causes complete or incomplete paralysis of voluntary mobility and absence, partial or total, of any sensitivity below the affected area; In addition, it also involves the lack of control over the sphincters of urination and intestinal evacuation, disorders of sexuality and fertility, alterations of the Vegetative…","s":"Withdrawn","tr":[],"o":["Bladder Function","Breathing Function","Motor Function","Quality of Life","Sexual Function","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04243161"},{"n":"NCT05558254","t":"ROBERT® as an Intervention to Enhance Muscle Strength After Spinal Cord Injury","d":"Spinal cord injury (SCI) is a devastating life event with long term consequences both physically and mentally. SCI is defined as either complete or incomplete according to the International Standards of the Neurological Classification of SCI. The primary consequence of a SCI is paralysis/partial paralysis affecting the person's ability to independently functioning in everyday life e.g. in and out of bed, sit to stand and walking. To regain the ability to transfer and walk the most important…","s":"Unknown","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05558254","su":"https://scitrials.org/trial/NCT05558254"},{"n":"NCT05401734","t":"Robot Assisted Gait Training in Persons With a Spinal Cord Injury","d":"Over the past decade, RAGT has emerged as a promising method for improving ambulation after spinal cord injury (SCI). Early reports of this therapy were very promising, yet a recent study suggested that even though RAGT may improve locomotor ability in the acute SCI population, it appears less functional to more conventional forms of ambulation such as wheelchair propulsion. What most of these studies have neglected to address, however, is the efficacy of RAGT as a therapeutic exercise…","s":"Unknown","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":[],"co":["Belgium"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05401734","su":"https://scitrials.org/trial/NCT05401734"},{"n":"NCT06775925","t":"Robot-assisted vs. Conventional Occupational Therapy of the Upper Limb in Individuals With Cervical Spinal Cord Injury","d":"The goal of this clinical trial is to learn the effects of robot-assisted therapy using the ArmeoSpring on upper limb function compared to conventional occupational therpay in individuals with cervical spinal cord injury (cSCI). The main questions it aims to answer are: \\- Which of the two forms of therapy, robot-assisted therapy or conventional occupational therapy, is more effective in terms of improving arm and hand function? The study is designed as a cross-over trial, which means that each…","s":"Recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06775925","su":"https://scitrials.org/trial/NCT06775925"},{"n":"NCT06805500","t":"Robotic Assisted Balance and Exoskeleton Training (REACTION) in Neurorehabilitation: a Feasibility Study","d":"The goal of this clinical trial is to explore the effect on walking speed of a new robotic assisted balance and gait trainer (REACTION) and their subsystems in individuals with neurological disorders. The study will provide insight in the feasibility of REACTION. Participants will: * Participate in two sessions in which every session contains a walking task and balance tasks * end the study with a semi-structured interview","s":"Completed","tr":["Exoskeleton"],"o":["Trunk Control","Walking Function"],"st":[],"co":["Netherlands"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06805500"},{"n":"NCT04250688","t":"Robotic Exoskeleton With Functional Electrical Stimulation in Acute Spinal Cord Injury","d":"The purpose of this study is to examine the effectiveness of mobility training using the Ekso robotic exoskeleton with functional electrical stimulation (FES) in persons affected by spinal cord injury; designated AIS classification A, B, C, or D. Traditionally, a person with an American Spinal Injury Association Impairment Scale (AIS) \"A\" injury, walking training is not performed. Even with AIS B, C and D injuries, although walking training may be appropriate, a person may not walk as much as…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04250688","su":"https://scitrials.org/trial/NCT04250688"},{"n":"NCT02749357","t":"Robotic Gait Training in Spinal Cord Injury","d":"INTRODUCTION: The ability to move and transfer own body in an effective manner, is frequently affected in people with a spinal cord injury with a negative impact in mood and quality of life, in such a way, that achieving an effective locomotion, is one of the main objectives in the rehabilitation program in a spinal cord injured patient. There are different modalities of locomotion training in spinal cord injury, being the robotic orthosis among them, and offering until now, positive outcomes…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Mental Health","Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Mexico"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02749357"},{"n":"NCT01432990","t":"Robotic Gait Training VS.Conventional Rehabilitation in SCI","d":"Until now, there's still no any strong evidence supported \"which is the best way to restoration walking ability\" in spinal cord injury. Most of the evidence suggest that, there is somehow better after gait rehabilitation for ASIA classification C and D but not improved walking ability for ASIA classification A and B. There is an RCT showed the evidence of repetitive locomotor training and physiotherapy could be improved walking and basic activities of daily living after stroke, these might be…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01432990","su":"https://scitrials.org/trial/NCT01432990"},{"n":"NCT03483766","t":"Robotic Rehabilitation for Spinal Cord Injury","d":"Individuals with spinal cord injury (SCI) have significant functional loss and poor quality of life. Individuals with cervical SCI are suffering much worse sickness within the SCI population. Tetraplegia resulting from cervical SCI bring a formidable emotional, physical, and financial burden in our society. Hand function is especially important to people with tetraplegia. Hand function is associated with independence in many activities, and impairments in upper extremity function can compound…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Bladder Function","Bowel Function","Hand Movement","Quality of Life"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03483766"},{"n":"NCT05473676","t":"Robotic Walking for Children Who Cannot Walk","d":"A common problem among children with nervous system disorders is difficulty walking on their own. This has impacts beyond mobility including short and long-term health conditions associated with physical inactivity and different developmental experiences as a result of the mobility impairments. A robotic trainer can both provide rehabilitation and be an assistive device to help compensate for difficulties. Figuring out how to prescribe it is critical to improve daily life for children with…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Bowel Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05473676"},{"n":"NCT01989806","t":"Robotic-assisted Locomotor Training on Mobility and Cardiopulmonary Function in Patients Suffering From Spinal Cord Injury","d":"Evidences showed that patients suffering from spinal cord injury (SCI) have poor mobility and higher chance to develop cardiopulmonary diseases, which leads to poor quality of life and shorter life expectancy. Different modalities were developed aiming at mobility restoration in SCI patients and robotic assisted body weight supported treadmill training is one of the latest technique in recent years. Yet there are scarce studies to investigate its effectiveness. The purpose of this study is to…","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01989806"},{"n":"NCT03239301","t":"Robotic-assisted Upper Extremity Training in Spinal Cord Injury Patients","d":"Study design: Controlled Trial Objective: To evaluate the effectiveness of robotic-assisted training of forearm and hand functions in spinal cord injury patients Setting: Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Turkey Methods: Forty patients were allocated into robotic and control groups. Both groups received conventional rehabilitation program for four weeks. Moreover, robotic group received robotic rehabilitation program tailored to the patient five times a…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03239301"},{"n":"NCT00385918","t":"Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI)","d":"This proposal investigates the hypothesis that progressive aerobic exercise with Lokomat is feasible in people with motor incomplete spinal cord injury, and three months of training will improve cardiovascular fitness and gait functionality when compared to physical therapy controls","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Blood Pressure","Bone Strength","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00385918"},{"n":"NCT06443151","t":"Role of Endothelial Function in SCI CVD Risk","d":"Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in…","s":"Recruiting","tr":["Observational"],"o":[],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06443151","su":"https://scitrials.org/trial/NCT06443151"},{"n":"NCT02458469","t":"Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI","d":"The purpose of this study is to look at the effect of exciting using drugs to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury (SCI) during sleep. During this part of the study participants will be asked to take buspirone (Buspar) (15-50mg per day), trazodone (100mg per day) and a placebo in a random fashion, each for a 2 week period (drug period) of time followed by two weeks without drugs…","s":"Completed","tr":["Drugs"],"o":["Breathing Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02458469"},{"n":"NCT04799782","t":"Role of Mirtazapine in Ameliorating Sleep Disordered Breathing","d":"The purpose of this study is to look at the effect of using Mirtazapine to target a specific pathway in the body, that relies on a natural chemical the body produces called 'serotonin', in patients with spinal cord injury (SCI) and non-injured persons during sleep. During this part of the study participants will be asked to take Mirtazapine (15mg per day) and a placebo in a random fashion, each for a one week period (drug period) of time followed by one week without drugs (washout period). The…","s":"Completed","tr":["Drugs"],"o":["Breathing Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04799782"},{"n":"NCT01601041","t":"Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury","d":"The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (\\>2 /year) symptomatic urinary tract infections in patients suffering from chronic (\\> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization. The following hypotheses will be tested: 1. The amount of residual urine after intermittent…","s":"Completed","tr":["Devices","Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01601041"},{"n":"NCT04708886","t":"Romosozumab in Women With Chronic SCI","d":"This two-year open-label pilot clinical trial will evaluate the efficacy and safety of romosozumab to treat bone loss in females with chronic spinal cord injury (SCI) and osteoporosis (OP). Participants will receive monthly injections of romosozumab during the first 12 months of the study. During the second year, participants will take oral alendronate tablets on a weekly basis.","s":"Completed","tr":["Drugs"],"o":["Bone Strength"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04708886"},{"n":"NCT04232657","t":"Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI","d":"Treatment for sublesional bone loss (osteoporosis) in persons with chronic, motor-complete spinal cord injury (SCI) has been limited and unsuccessful to date. Romosozumab, a sclerostin antagonist, has potential to increase bone formation (anabolic) and decrease bone resorption (anti-catabolic) in persons with chronic SCI. Conventional anti-resorptive therapy alone would not be anticipated to reverse sublesional bone loss in a timely manner because the skeleton below the level of lesion in…","s":"Active, not recruiting","tr":[],"o":["Bone Strength"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04232657","su":"https://scitrials.org/trial/NCT04232657"},{"n":"NCT03394560","t":"rTMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury","d":"The aim of this study is to verify the efficacy of body weight-support treadmill training combined with high-frequency rTMS in improving the sensory-motor function of adult patients with chronic incomplete thoracolumbar spinal cord injury.","s":"Unknown","tr":["Brain Stimulation","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03394560","su":"https://scitrials.org/trial/NCT03394560"},{"n":"NCT06886308","t":"RTsMS and Body Weight-support Treadmill Training After Incomplete Spinal Cord Injury","d":"The aim of this study is to assess the feasibility of combining rTsMS with BWSTT for gait and sensorimotor recovery in individuals with incomplete spinal cord injury.","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06886308"},{"n":"NCT00980434","t":"S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma","d":"The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures. If there is a injury to the neuronal structures these two proteins could be secreted into the serum and add evidence to the severity of the injury.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Austria"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00980434"},{"n":"NCT06565351","t":"S-cystatin C vs.Injection Clearance Measurements to Estimate Kidney Function in Patients With Spinal Cord Injuries","d":"* In individuals with spinal cord injury (SCI) kidney function defined as Glomerular Filtration Rate (GFR) is monitored by injection of e.g.99mDTPA and subsequent blood sampling (DTPA-clearance) * GFR calculated from plasma samples of the endogenous substance s-Cystatin C (eGFR cystatin C) was compared to DTPA-clearance in 248 individuals with SCI. * It is concluded that eGFR based on plasma s-cystatin C can replace the more tedious 99mDTPA-clearance procedures in individuals with SCI","s":"Completed","tr":["Drugs","Observational"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06565351"},{"n":"NCT03083366","t":"Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury","d":"The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury. Within 12-weeks of injury, participants will either receive an implanted nerve stimulator (like a pace-maker for the bladder) or standard care for neurogenic bladder. Patients will be assigned to one of these groups at random and followed for one year. The hypothesis is that early stimulation of the nerves will help prevent the…","s":"Terminated","tr":["Devices","Electrical Stimulation"],"o":["Bladder Function","Quality of Life"],"st":["California","Utah"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03083366"},{"n":"NCT03819062","t":"Sacral Neuromodulation as Treatment for Chronic Constipation","d":"The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Bowel Function","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03819062"},{"n":"NCT02777281","t":"Safe and Effective Shoulder Exercise Training in Manual Wheelchair Users With SCI","d":"This study will compare two exercise programs in an interventional study for manual wheelchair users with spinal cord injury and shoulder pain. Subjects without spinal cord injury will also be enrolled to compare exercise approaches.","s":"Completed","tr":["Rehabilitation"],"o":["Pain Management"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02777281"},{"n":"NCT06976229","t":"Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial","d":"This Phase I clinical trial is designed to evaluate the safety, tolerability of XS228 ( iPSC-Derived Motor Neuron Progenitor Cells) in patients with Subacute Spinal Cord Injury","s":"Recruiting","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06976229","su":"https://scitrials.org/trial/NCT06976229"},{"n":"NCT01769872","t":"Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With Spinal Cord Injury","d":"The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with spinal cord injury","s":"Completed","tr":["Stem Cells"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01769872"},{"n":"NCT02981576","t":"Safety and Effectiveness of BM-MSC vs AT-MSC in the Treatment of SCI Patients.","d":"Spinal Cord Injury (SCI) is a devastating condition that leads to permanent functional and neurological deficits in injured individuals. The limited ability of the Central Nervous System (CNS) to spontaneously regenerate impairs axonal regeneration and functional recovery of the spinal cord. The leading causes are motor-vehicle crashes, sports-associated accidents, falls, and violence-related injuries. Unfortunately, there is still no effective clinical treatment for SCI. In recent years…","s":"Completed","tr":["Stem Cells"],"o":["Regeneration"],"st":[],"co":["Jordan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02981576"},{"n":"NCT07404761","t":"Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments","d":"This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or traumatic brain injury (TBI). Participants will be randomized to receive either SSMD therapy plus standard rehabilitation care or standard functional electrical stimulation (FES) plus standard care. Subjects will complete approximately 25 supervised treatment sessions over…","s":"Recruiting","tr":["Devices","Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["Israel"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07404761"},{"n":"NCT01186679","t":"Safety and Efficacy of Autologous Bone Marrow Stem Cells in Treating Spinal Cord Injury","d":"The projected data related to the burden of spinal cord injuries induced limb paralysis in India is quite alarming. This is attributed to the rapid industrialization and economical development in the country. Increase in vehicular traffic has caused numerous road traffic accidents. Rapid increase in populations, development in the computer technology and real estate business lead to construction of huge buildings which indirectly adds to the injuries due to fall. Spinal cord injuries could not…","s":"Completed","tr":["Safety","Stem Cells","Surgical Procedure"],"o":[],"st":[],"co":["India"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01186679"},{"n":"NCT01676441","t":"Safety and Efficacy of Autologous Mesenchymal Stem Cells in Chronic Spinal Cord Injury","d":"This phase II/III clinical trial is designed to evaluate the safety and efficacy of autologous Mesenchymal Stem Cells (MSC) transplanted directly into the injured spinal cord.","s":"Terminated","tr":["Drugs","Stem Cells"],"o":["Motor Function","Sensory Function"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01676441"},{"n":"NCT00610337","t":"Safety and Efficacy of Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury","d":"This is a multicenter, randomized, double-blind, placebo-controlled, Phase IIb study to be conducted in North America and Europe and will include male and female subjects with acute cervical SCI, 18 to 62 years of age, who receive clinical trial material (CTM) within 72 hours of injury. This study is being undertaken to evaluate and confirm the safety and efficacy of CETHRIN®. This adaptive study has been designed to efficiently identify the safest and most effective dose in Phase IIb which…","s":"Withdrawn","tr":["Drugs"],"o":["Arm Movement","Leg Movement","Motor Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00610337"},{"n":"NCT07457645","t":"Safety and Efficacy of High-Channel Implanted BCI for Motor Function Improvement in Tetraplegia Patients","d":"This is an open-label single-arm clinical study conducted at designated clinical trial institutions, with three overall phases: a 3-month main study, a 3-month extension, and a 3-month follow-up. The main study includes screening/baseline, preoperative preparation, surgery, upper limb rehabilitation adjustment, and pneumatic hand function training-specifically, preoperative brain and spinal cord imaging for electrode placement in eligible subjects, implantation of high-channel electrodes, and…","s":"Not yet recruiting","tr":["Brain Machine Interface (BMI)"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07457645","su":"https://scitrials.org/trial/NCT07457645"},{"n":"NCT00835224","t":"Safety and Efficacy of L-NAME and Midodrine to Increase MAP","d":"After a spinal cord injury the brain is no longer completely in control of the body below the level of injury. This affects many organs and systems in the body, we are interested in understanding how a spinal cord injury affects blood pressure and blood flow to the brain. We are going to study blood pressure while the person is seated in a wheelchair before and after we give the subject medications which should increase blood pressure in a laboratory setting and over the course of a normal day…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00835224"},{"n":"NCT00041717","t":"Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury","d":"Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs. In people with spinal cord injury, some fibers may be destroyed at the site of injury, while others remain connected but do not work correctly to carry electrical impulses. As a result, subjects with an incomplete spinal cord injury may have spasticity which is muscle spasms or muscle stiffness that makes movement difficult. Fampridine-SR is an experimental…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Bowel Function","Leg Movement","Sexual Function","Spasticity"],"st":["Alabama","Arizona","Arkansas","California","Delaware","District of Columbia","Florida","Georgia","Illinois","Massachusetts","Michigan","Minnesota","Missouri","Montana","New Jersey","New York","North Carolina","North Dakota","Ohio","Pennsylvania","Utah","Virginia","West Virginia"],"co":["Canada","United States"],"lc":45,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00041717"},{"n":"NCT01683838","t":"Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury","d":"Normally, nerve fibers carry electrical impulses through the spinal cord, providing communication between the brain and the arms and legs. In people with spinal cord injury, some fibers may be destroyed at the site of injury, while others remain connected but do not work correctly to carry electrical impulses. As a result, subjects with an incomplete spinal cord injury may have spasticity which is muscle spasms or muscle stiffness that makes movement difficult. Fampridine-SR is an experimental…","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Bowel Function","Leg Movement","Motor Function","Sexual Function","Spasticity"],"st":["Alabama","California","Colorado","Connecticut","Illinois","Massachusetts","Michigan","Minnesota","Missouri","New York","North Carolina","Ohio","Pennsylvania","Texas","Virginia","Washington","Wisconsin"],"co":["Canada","United States"],"lc":30,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01683838"},{"n":"NCT00856440","t":"Safety and Efficacy of Routine Colonoscopy Preparations","d":"Periodic screening for colon cancer has become the standard of care in individuals over the age of 50. In this context, it is generally accepted that colonoscopy is the most sensitive modality for the detection of colon cancer and/or pre malignant colon pathology. As currently performed, however, colonoscopy requires that stool be eliminated from the colon before the examination. If stool remains in the colon, visualization of the bowel will be partially or completely impaired and limits the…","s":"Completed","tr":["Drugs","Observational"],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00856440"},{"n":"NCT01598103","t":"Safety and Efficacy of SAF312 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Lesions","d":"This study will assess the safety, tolerability and efficacy of SAF312 in patients with overactive bladder disease due to spinal cord lesions. The overactive bladder of patients who qualify for this study is insufficiently managed by antimuscarinic therapy, or patients poorly tolerate the treatment with antimuscarinic drugs. The efficacy of SAF312 will be primarily determined via urodynamic measurements.","s":"Terminated","tr":["Drugs"],"o":["Bladder Function","Sensory Function","Spasticity"],"st":[],"co":["Germany","Netherlands","Switzerland"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01598103"},{"n":"NCT02490501","t":"Safety and Efficacy of SC0806 (Fibroblast Growth Factor 1 and a Device) in Traumatic Spinal Cord Injury Subjects","d":"This is an open, randomized, rehabilitation-controlled study in subjects with complete Traumatic Spinal Cord Injury, where the active treatment consists of a surgical implantation of SC0806 (a biodegradable device with heparin-activated FGF1 and nerve implants).","s":"Completed","tr":[],"o":["Regeneration"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02490501","su":"https://scitrials.org/trial/NCT02490501"},{"n":"NCT02429206","t":"Safety and Efficacy of SQIN™ on Xerosis in Adults With Mobility Problems and Paralysis","d":"In the general population, xerosis is often caused by external factors such as seasonal changes. In that case, the best way to relieve dry skin is to use a standard moisturizer. However, for those suffering of mobility problems due to age or paralysis (e.g., spinal cord injury, multiple sclerosis, Parkinson's, etc), xerosis is often severe and chronic because of the multiple causes (endogenous rather than exogenous ones) underlying such mobility impairment-related skin problems. This study is a…","s":"Completed","tr":[],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02429206"},{"n":"NCT02027246","t":"Safety and Efficacy of Stem Cell Therapy in Spinal Cord Injury","d":"The aim of this study was to study the effect of stem cell therapy on common symptoms of spinal cord injury patients.","s":"Withdrawn","tr":["Stem Cells"],"o":["Quality of Life"],"st":[],"co":["India"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02027246"},{"n":"NCT06782113","t":"Safety and Efficacy of the UNILEXA Exoskeleton for Regular Verticalization and Assisted Walking","d":"The primary objective of this clinical follow-up is to analyze data regarding the safety of the UNILEXA passive exoskeleton post-market. The secondary objective is to assess the effectiveness of the device in improving activities of daily living (ADL) through improved mobility, endurance and health-related quality of life (QoL). The aim of this study is to provide real-world evidence to support wider clinical and home use of the exoskeleton. This observational study is designed for 6…","s":"Active, not recruiting","tr":["Exoskeleton"],"o":[],"st":[],"co":["Czechia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06782113","su":"https://scitrials.org/trial/NCT06782113"},{"n":"NCT04295538","t":"Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)","d":"Acute Spinal Cord Injury (SCI) is a rare injury that leads to permanent neuromotor impairment and sudden disability. Approximately 25,000 people experience cervical SCI in the United States, Europe, and Japan every year. The purpose of this study is to see if elezanumab is safe and assess change in Upper Extremity Motor Score (UEMS) in participants with acute traumatic cervical SCI. Elezanumab is an investigational drug being developed for the treatment of SCI. Elezanumab is a monoclonal…","s":"Completed","tr":["Drugs"],"o":["Arm Movement","Motor Function","Quality of Life","Regeneration"],"st":["California","Georgia","Illinois","Kentucky","Massachusetts","Michigan","Missouri","New Jersey","North Carolina","Oregon","Pennsylvania","Virginia","West Virginia","Wisconsin"],"co":["Australia","Canada","Israel","Japan","South Korea","Spain","United States"],"lc":41,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04295538"},{"n":"NCT01135108","t":"Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Spinal Cord Injury","d":"The purpose of this study is to determine whether KAI-1678 is effective in the treatment of pain associated with spinal cord injury.","s":"Completed","tr":["Drugs","Safety"],"o":["Pain Management"],"st":[],"co":["Australia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01135108"},{"n":"NCT04812431","t":"Safety and Exploratory Efficacy of Transplantation Therapy Using PSA-NCAM(+) NPC in AIS-A Level of Sub-acute SCI","d":"This study intends to evaluate the safety and exploratory efficacy of transplantation therapy using neural precursor cells (PSA-NCAM(+) NPC) derived from the human embryonic stem cell line for the treatment of paralysis and other related symptoms from sub-acute spinal cord injury.","s":"Recruiting","tr":[],"o":["Regeneration"],"st":[],"co":["South Korea"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT04812431","su":"https://scitrials.org/trial/NCT04812431"},{"n":"NCT02417532","t":"Safety and Feasibility Evaluation of Robot Assisted Physiotherapy Exercises With REX","d":"Prospective, Open label, single arm, non-randomized, non-comparative registry study of Robot-Assisted Physiotherapy Exercises with the REX Robot powered exercise system in patients with Spinal cord or other injury preventing unsupported patient ambulation.","s":"Completed","tr":["Devices","Rehabilitation","Safety"],"o":["Walking Function"],"st":[],"co":["Australia","New Zealand","United Kingdom"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02417532"},{"n":"NCT07384052","t":"Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury","d":"The purpose of this study is to find out whether insulin, a drug approved by the FDA for the treatment of diabetes mellitus, is safe when administered as a nasal spray (intranasally) to people who have experienced a spinal cord injury. While insulin nasal spray has been shown to be safe in many patient populations, it has not yet been studied in people with spinal cord injury. This study would be the first step to developing insulin nasal spray as a treatment for spinal cord injury in the…","s":"Recruiting","tr":["Drugs"],"o":[],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07384052","su":"https://scitrials.org/trial/NCT07384052"},{"n":"NCT06543277","t":"Safety and Feasibility of Paired Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury","d":"The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord injury.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06543277","su":"https://scitrials.org/trial/NCT06543277"},{"n":"NCT05601661","t":"Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury","d":"The purpose of this study is to determine the safety and feasibility of pairing vagus nerve stimulation (VNS) with rehabilitation and to determine the efficacy of pairing VNS with rehabilitation.","s":"Completed","tr":["Devices","Rehabilitation","Safety","Surgical Procedure"],"o":["Arm Movement","Blood Pressure","Breathing Function","Hand Movement","Mental Health","Motor Function","Pain Management","Quality of Life","Spasticity"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05601661"},{"n":"NCT05926310","t":"Safety and Feasibility of TWIICE Rise","d":"The aim of this study is to assess the safety and the feasibility of two versions of TWIICE Rise for exoskeleton-assisted ambulation in patients with a spinal cord injury. This study is done in two phases: The first phase evaluates the safety and feasibility of TWIICE Rise 0.0 with 5 patients over 6 sessions in clinic. The second phase is being conducted with TWIICE Rise 1.0. This version has potentially improved functionalities based on feedback from Phase 1. Safety and feasibility will be…","s":"Unknown","tr":["Exoskeleton"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05926310","su":"https://scitrials.org/trial/NCT05926310"},{"n":"NCT07461259","t":"Safety and Feasibility of TWIICE Rise - Phase 2","d":"The aim of this study is to assess the safety and the feasibility of two versions of TWIICE Rise for exoskeleton-assisted ambulation in patients with a spinal cord injury. This study is done in two phases: The first phase evaluates the safety and feasibility of TWIICE Rise 0.0 with 5 patients over 6 sessions in clinic. The second phase is being conducted with TWIICE Rise 1.0. This version has potentially improved functionalities based on feedback from Phase 1. Safety and feasibility will be…","s":"Recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07461259","su":"https://scitrials.org/trial/NCT07461259"},{"n":"NCT01046786","t":"Safety and Feasibility of Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord","d":"To investigate the feasibility, safety, efficacy and optimal dose of umbilical cord blood mononuclear cell transplant in the treatment of chronic spinal cord injuries.","s":"Completed","tr":["Drugs","Safety","Stem Cells"],"o":["Motor Function","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Hong Kong"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01046786"},{"n":"NCT02237547","t":"Safety and Feasibility Study of Cell Therapy in Treatment of Spinal Cord Injury","d":"Human Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSC) and Bone Marrow Mononuclear Cells (BMMC) from the patient injected into the spinal fluid intrathecally and injected intravenously (IV) is a safe and therapeutic procedure for spinal cord injury (SCI) patients.","s":"Withdrawn","tr":["Drugs","Safety","Stem Cells"],"o":[],"st":[],"co":["Panama"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02237547"},{"n":"NCT01251549","t":"Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO)","d":"ReWalk suit developed by Argo Medical Technologies is designed to enable people with lower limb disabilities to carry out routine ambulatory functions (stand, walk etc.); it can be used by people with disabilities such as spinal cord injury, brain injury, stroke, multiple sclerosis, cerebral palsy and other pathologies that produce severe walking impairments.","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Leg Movement","Walking Function"],"st":["Pennsylvania"],"co":["Italy","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01251549"},{"n":"NCT04096950","t":"Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury","d":"The purpose of this study is to assess the safety, tolerability and pharmacokinetics of MT-3921 in subjects with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":[],"st":["California","Illinois","Michigan","Mississippi","Missouri","New Mexico","North Carolina","Ohio","Pennsylvania","Virginia","Wisconsin"],"co":["United States"],"lc":13,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04096950"},{"n":"NCT00431171","t":"Safety and Pharmacokinetics Study of Oral Lithium in Patients With Chronic Spinal Cord Injury","d":"The current study is a phase I open-label clinical trial to examine plasma levels after oral lithium treatments in 20 subjects with chronic spinal cord injury. The subjects will receive standard doses of oral lithium used in treatment of manic depression. The goal of the trial is to show feasibility and safety of maintaining plasma levels of 0.6 mmol/L to 1.2 mmol/L for six weeks in subjects with chronic spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Mental Health"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00431171"},{"n":"NCT00531466","t":"Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury","d":"A drug called AV650 (tolperisone HCl) will be given to patients who have spasticity following a spinal cord injury. This study has three purposes: 1. To determine whether AV650 is safe for patients with spinal cord injury; 2. To assess what the body does with AV650 once it is ingested; and, 3. To gather some early evidence as to whether AV650 is effective in treating spasticity in patients with spinal cord injury.","s":"Terminated","tr":["Drugs"],"o":["Spasticity"],"st":["California","Florida","Georgia","Maryland","New Jersey","North Carolina","Pennsylvania","Virginia"],"co":["Canada","United States"],"lc":10,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00531466"},{"n":"NCT02917291","t":"Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury","d":"The main objective of the study is the evaluation of the safety and tolerability of FAB117-HC (a medicinal product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed with H2O2, HC016 cells) administered at a single-time point to patients with acute thoracic traumatic spinal cord injury (SCI). The study will also include initial exploration of potential clinical efficacy. Dose levels of 20 million and 40 million cells will be administered.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Spain"],"lc":9,"rlc":9,"cu":"https://clinicaltrials.gov/study/NCT02917291","su":"https://scitrials.org/trial/NCT02917291"},{"n":"NCT06347575","t":"Safety and Tolerability of a Novel Implantable Neurostimulator for Ameliorate Erectile Function on Spinal Cord Injured Patients","d":"The main objective of the study is to assess the safety and tolerability of cavernous nerve electrical stimulation in patients with spinal cord injured (SCI) by assessing and measuring complications. As the secondary objectives, despite the limited cohort size, this long-term study aims to obtain preliminary data on efficacy of cavernous nerve stimulation to improve erectile function for sexual intercourse, as well as to assess patient's satisfaction using: * Objective assessment of the…","s":"Withdrawn","tr":["Devices","Electrical Stimulation","Safety","Surgical Procedure"],"o":["Pain Management","Sexual Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06347575"},{"n":"NCT03168828","t":"Safety and Tolerability of TAR-302-5018 in Subjects With Neurogenic Detrusor Overactivity Resulting From Spinal Cord Injury","d":"The purpose of this study is to determine if TAR-302-5018, an investigational drug-delivery system, is safe and tolerable in patients with neurogenic detrusor overactivity (NDO) resulting from spinal cord injury (SCI).","s":"Completed","tr":["Drugs","Safety"],"o":["Bladder Function"],"st":["Michigan","North Carolina","Virginia","Washington"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03168828"},{"n":"NCT06772077","t":"Safety and Usability of the ATLAS 2030 Exoskeleton in Pediatric Patients With Spinal Cord Injury","d":"The goal of this clinical trial is to analyze the usability and safety of the robotic gait ATLAS 2030 in a cohort of pediatric patients with Spinal Cord Injury, with the aim of extending its indication for use to pediatric spinal cord injury","s":"Recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06772077","su":"https://scitrials.org/trial/NCT06772077"},{"n":"NCT05265377","t":"Safety and Usability of the STELO Exoskeleton in People With Acquired Brain Injury and Spinal Cord Injury","d":"Gait impairment in people with acquired brain injury (ABI) and spinal cord injury (SCI) can be very heterogeneous. For this reason, STELO has been developed: a new concept of exoskeleton based on modular technology for gait assistance. It allows a personalised configuration according to the functional capacity of each patient, as the therapist can choose which robotic joints to use depending on the therapeutic goal and on the patient recovery phase. The objective is to analyse the usability of…","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Blood Pressure","Pain Management","Walking Function"],"st":[],"co":["Spain"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05265377"},{"n":"NCT01739023","t":"Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Subacute SCI","d":"The purpose of this study is to assess the safety of autologous human Schwann cells (ahSC) transplantation in subjects with subacute SCI. For humans with subacute SCI, we hypothesize that axons might show improved function if myelin repair is induced with the implantation of ahSC. In addition spinal cord cavitation may be reduced, and neural sprouting and plasticity may be enhanced via neurotrophic effects.","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Pain Management","Plasticity","Quality of Life","Spasticity"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01739023"},{"n":"NCT05739734","t":"Safety of CRIS100 on Treatment Spinal Cord Injury","d":"The goal of this clinical trial is to test CRIS100 treatment in participants with acute thoracic spinal cord injury. The main questions it aims to answer are: * safety of CRIS100 * efficacy of CRIS100 Participants will receive 100 mcg CRIS100 in the epicenter of the spinal injury, within 72 hours of the trauma.","s":"Not yet recruiting","tr":["Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05739734"},{"n":"NCT05152290","t":"Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for SCI","d":"This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Spinal Cord Injury.","s":"Recruiting","tr":["Stem Cells"],"o":[],"st":[],"co":["Antigua and Barbuda","Greece"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05152290"},{"n":"NCT05018793","t":"Safety of Cultured Autologous Adult Adipose Derived Mesenchymal Stem Cell Versus Cultured Allogeneic Adult Umbilical-cord Derived Mesenchymal Stem Cell Intrathecal Injection for SCI","d":"This trial will study the safety and efficacy of intrathecal injection of cultured autologous adult adipose derived mesenchymal stem cells versus cultured allogeneic adult umbilical-cord derived mesenchymal stem cells for the treatment of spinal cord injury","s":"Recruiting","tr":["Drugs","Stem Cells"],"o":[],"st":[],"co":["Antigua and Barbuda","Greece"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05018793"},{"n":"NCT00876889","t":"Safety of Riluzole in Patients With Acute Spinal Cord Injury","d":"The purpose of the study is to find out if the use of the drug Riluzole is both safe and improves outcome in patients with acute traumatic spinal cord injury (SCI).","s":"Completed","tr":["Drugs","Observational"],"o":[],"st":["Florida","Kentucky","Maryland","Pennsylvania","Texas","Virginia"],"co":["Canada","United States"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00876889"},{"n":"NCT07090473","t":"Safety of Transcutaneous Electrical Stimulation Potentiating Recovery in Acute Spinal Cord Injury Syndromes","d":"The goal of this study is to test whether electrical stimulation from the skin surface starting 3 days after spinal cord injury (SCI) is safe and may help patients recover their movement. The main questions it aims to answer are: * is starting electrical stimulation 3 days post SCI safe? * can starting electrical stimulation 3 days post SCI help patients recover movement? This study will be done in two phases. Both phases will be done during the patient's stay in the hospital/intensive care…","s":"Recruiting","tr":["Electrical Stimulation"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07090473","su":"https://scitrials.org/trial/NCT07090473"},{"n":"NCT04205019","t":"Safety Stem Cells in Spinal Cord Injury","d":"Mono-center, open label study to investigate the safety of Neuro-Cells in 10 end stage (chronic) traumatic spinal cord injury (TSCI) patients, when administered once intrathecally. TSCI is a rare disease without cure perspectives and Neuro-Cells is an autologous fresh stem cells containing product (one batch / one patient).","s":"Completed","tr":[],"o":["Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04205019"},{"n":"NCT01217008","t":"Safety Study of GRNOPC1 in Spinal Cord Injury","d":"The purpose of the study is to evaluate the safety of GRNOPC1 administered at a single time-point between 7 and 14 days post injury, inclusive, to patients with neurologically complete spinal cord injuries (SCI).","s":"Completed","tr":[],"o":[],"st":["Alabama","California","Georgia","Illinois","Maryland","Pennsylvania","Wisconsin"],"co":["United States"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01217008"},{"n":"NCT01772810","t":"Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI","d":"This is a safety study of human spinal cord-derived neural stem cell (HSSC) transplantation for the treatment of chronic spinal cord injury.","s":"Unknown","tr":[],"o":["Regeneration"],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01772810","su":"https://scitrials.org/trial/NCT01772810"},{"n":"NCT02096913","t":"Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury","d":"The Ibuprofen - Spinal Cord Injury (SCI) - Safety trial investigates tolerability and feasibility of \"small molecule\" (Ibuprofen) mediated Rho-inhibition as putative neuroprotective, plasticity-enhancing and neurorestaurative intervention. The primary safety analysis is based on the incidence of severe gastrointestinal bleedings. In addition, the feasibility of recruitment procedure, and oral administration of the compound within the multidisciplinary setting of acute intensive medical care…","s":"Completed","tr":["Drugs","Safety"],"o":["Bowel Function","Motor Function","Pain Management","Plasticity","Sensory Function","Spasticity"],"st":[],"co":["Germany"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02096913"},{"n":"NCT01909154","t":"Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia","d":"The purpose of this study is to confirm the security, and detect the effect of the local administration in damaged nervous tissue, of autologous bone marrow stromal cells.","s":"Completed","tr":["Stem Cells"],"o":["Bladder Function","Pain Management"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01909154"},{"n":"NCT02065830","t":"Safety Study of Outdoor and Indoor Mobility in People With Spinal Cord Injury (ROBOtics Spinal Cord Injury EKSO).","d":"The aim of this study will be to evaluate the safety and the efficacy of a new robotic exoskeleton device in subjects with Spinal Cord Injury (SCI) and in subjects with other neurological disease with an impairment of lower limbs.","s":"Terminated","tr":["Devices","Exoskeleton"],"o":["Blood Pressure","Walking Function"],"st":[],"co":["Italy"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02065830"},{"n":"NCT06000592","t":"Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI","d":"Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI). A critical need exists for the identification of safe, practical, and effective treatment options that stabilize blood pressure (BP) after traumatic SCI. Recent published evidence suggests that transcutaneous Spinal Cord Stimulation (TSCS) can be used to raise seated BP, and…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06000592","su":"https://scitrials.org/trial/NCT06000592"},{"n":"NCT07159360","t":"Safety, Usability, and Effectiveness of a Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders.","d":"Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk. CLINICAL EXPLORER is a clinical-use robotic device for gait training, representing the evolution of the ATLAS 2030 exoskeleton and the EXPLORER device for home use. The aim of this study is to evaluate the safety and usability of CLINICAL EXPLORER .","s":"Not yet recruiting","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Blood Pressure","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Mexico","Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07159360"},{"n":"NCT03863379","t":"Sarcopenic Obesity in Neurodisabilities","d":"To describe the frequency and thresholds for sarcopenic obesity in neurodisabled persons and the fat and lean mass distribution based on various neurodisabilities","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03863379"},{"n":"NCT05353842","t":"Scale Up of Project Workout on Wheels Internet Intervention (WOWii)","d":"This study is designed is to test the feasibility, fidelity, and effectiveness of scaling up an evidence- and theory-based virtually delivered physical activity intervention (WOWii) for individuals living with chronic SCI for delivery through other rehabilitation settings. The study outcomes address (1) feasibility based on participant enrollment, retention, and program engagement; (2) fidelity of intervention delivery; and (3) program effectiveness based on subjective and objective exercise…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["Georgia","New Jersey"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05353842","su":"https://scitrials.org/trial/NCT05353842"},{"n":"NCT05822297","t":"SCED Myokines and Cognition in SCI","d":"Rationale: Individuals with spinal cord injury (SCI) suffer from accelerated cognitive aging. In able-bodied individuals, a vast amount of studies have shown that exercise interventions can improve cognitive function. Myokines (i.e. factors released into the blood stream from muscle cells) are considered one of the mediators of this beneficial effect. Neuromuscular electrical stimulation (NMES), used to replace or support muscle training in disabled individuals with poor exercise possibilities…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05822297","su":"https://scitrials.org/trial/NCT05822297"},{"n":"NCT00693563","t":"Scheduled Telephone Intervention for Individuals With Spinal Cord Injury and Their Families","d":"The purpose of this study is to evaluate whether scheduled telephone intervention with individuals with spinal cord injury (SCI) and their caregivers in the first year following discharge from acute inpatient rehabilitation will reduce rehospitalizations and emergency room visits as well as improve adjustment to SCI.","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00693563"},{"n":"NCT03922802","t":"SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training","d":"This is a single blind, sham controlled crossover trial that will evaluate the effectiveness of acute intermittent hypoxia therapy (AIH) combined with transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals after spinal cord injury.","s":"Completed","tr":["Electrical Stimulation","Intermittent Hypoxia","Rehabilitation","Transcutaneous Stimulation"],"o":["Trunk Control","Walking Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03922802"},{"n":"NCT07425470","t":"SCI Epidemiology and Complications","d":"The aim of this study was to epidemiologically evaluate patients diagnosed with spinal cord injury who were admitted to our clinic over the last five years and, unlike similar studies, to investigate the presence of complications in these patients. The investigators hope that this study will contribute to the literature by raising awareness of spinal cord injury epidemiology and potential complications.","s":"Not yet recruiting","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07425470"},{"n":"NCT04818814","t":"SCI Pain App Intervention Study","d":"The purpose of this study is to find out if using an app is a feasible and acceptable treatment for chronic pain in persons with spinal cord injury. Participants will have a 50% chance of being asked to listen to 10 minutes of audio-guided meditations using an app each day for six weeks, and a 50% chance of being asked to listen to 10 minutes of engaging and distracting presentations about topics of interest to the individual (TED Talks) for six weeks. All participants will be asked to complete…","s":"Terminated","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04818814"},{"n":"NCT05063617","t":"SCI Step Together: Improving Physical Activity Participation Among Individuals With SCI Who Ambulate","d":"The project aims to test the feasibility of a new digital (mHealth) physical activity support program, delivered through an innovative mHealth platform (Curatio) for individuals living with spinal cord injury (SCI) who walk. The rationale for this project is to understand whether a mHealth intervention for increasing the amount and quality of physical activity is feasible for individuals with SCI who walk. The plan is to assess engagement, acceptability and feasibility in addition to primary…","s":"Completed","tr":["Devices"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05063617"},{"n":"NCT04059718","t":"SCI Thrive: Efficacy of a Peer-led Online Self-Management Program","d":"SCI Thrive is a randomized controlled trial to test the efficacy of SCI Thrive (6 week Peer-Led Online Self-Management Program) to improve quality of life and self-efficacy for individuals with SCI.","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04059718"},{"n":"NCT06677905","t":"SCI&U Peer Health Coaching Program for Individuals Newly Discharged From Inpatient Rehabilitation","d":"The goal of this clinical trial is to learn if the online program and web-based platform for delivery of self-management services to people with spinal cord injury (SCI) called \"SCI \\& U\" can support transitions from hospital to the community after injury. Specifically, can providing support from trained peer health coaches via the SCI \\& U web-based self-management program increase health self-management among those within three years of a spinal cord injury with a planned discharge to or…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Connecticut"],"co":["Canada","United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06677905","su":"https://scitrials.org/trial/NCT06677905"},{"n":"NCT07167290","t":"SCI-FACT: The Effectiveness of Focused ACT for SCI Patients","d":"Research has found that patients with a Spinal Cord Injury (SCI) suffer with longstanding mental health difficulties, likely due to the impact of the lifelong physical and health problems that come with their injury. Therefore, it is important to make sure that there is effective psychological support available to them. Unfortunately, research shows that the most commonly used therapy approach, CBT, has very inconsistent evidence regarding its effectiveness for SCI patients. It has also been…","s":"Not yet recruiting","tr":[],"o":["Mental Health"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07167290","su":"https://scitrials.org/trial/NCT07167290"},{"n":"NCT05764135","t":"SCI-Lynx: A Mobile Platform for Physical Activity Social Support for People With SCI Pilot Study","d":"Physical activity is important to maintain health, fitness, and function in people with spinal cord injury (SCI) and social support is one of the most effective ways to increase physical activity participation. However, a large proportion of people with SCI are physically inactive and do not engage in recreational activities due to environmental and physical challenges. Many people with SCI also experience challenges with social connection, which may make engaging in physical activities more…","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05764135"},{"n":"NCT01141647","t":"SCI-VIP: Predictive Outcome Model Over Time for Employment (PrOMOTE)","d":"This study will be an extension of the Spinal Cord Injury Vocational Integration Program (SCI-VIP). The study involves research about how to help Veterans with spinal cord injury (SCI) gain employment. Vocational rehabilitation is a special field of service aimed at putting persons with disabilities in the best possible position to become employed. The Veterans Administration has a long history of providing vocational rehabilitation for Veterans with mental health issues and has recently…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health"],"st":["California","Florida","Massachusetts","Ohio","Texas","Virginia"],"co":["United States"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01141647"},{"n":"NCT01236976","t":"SCIPA Full-On :Intensive Exercise Program After Spinal Cord Injury","d":"The study is a multi-centre, assessor-blind, randomised controlled phase III trial in patients with with complete or incomplete spinal cord injury between C6 and T12. A total of 188 participants will be randomised into two groups, the experimental group and the control group. The control group participants will receive an upper body strength and fitness program, conducted for 2-3 hours, three times per week for 12 weeks, while the experimental group participants will receive a comprehensive…","s":"Completed","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Leg Movement","Mental Health","Motor Function","Quality of Life","Trunk Control"],"st":[],"co":["Australia","New Zealand"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01236976"},{"n":"NCT05869968","t":"SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI","d":"The purpose of this observational research study is to better understand immune responses to vaccines against viruses (influenza or SARS-CoV2). The goal is to determine any differences in immune responses to vaccines in uninjured people and in people living with spinal cord injuries, who are typically at increased risk of infections.","s":"Active, not recruiting","tr":["Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05869968"},{"n":"NCT07511244","t":"SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI","d":"This clinical trial aims to evaluate the safety and efficacy of spinal cord stimulation (SCS) in treating patients with urinary and bowel dysfunction after spinal cord injury (SCI). SCI is a highly disabling condition that can lead to sensory, motor, and autonomic nervous system dysfunction below the injury level. Neurogenic bladder and bowel dysfunction are common sequelae of SCI, seriously affecting patients' quality of life. Currently, clinical treatments can only partially alleviate urinary…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07511244","su":"https://scitrials.org/trial/NCT07511244"},{"n":"NCT04047992","t":"Seated Balance Using the Indego™","d":"Exoskeleton-assisted walking (EAW) provides a new mobility option and appears to have potential therapeutic benefits for persons with SCI. However, present day technology is not sufficient to replace the wheelchair. During EAW, users stand upright, maintain static and dynamic balance by actively and passively stimulating trunk and lower limb muscles in a manner not challenged during wheelchair use. Preliminary results in our laboratory suggest that the indirect balance challenges and postural…","s":"Recruiting","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04047992","su":"https://scitrials.org/trial/NCT04047992"},{"n":"NCT03886857","t":"Segmental Mechanisms of Transcutaneous Spinal Cord Stimulation for Spasticity Control","d":"The aim of the pilot study is to gain first insights into the interaction of transcutaneous spinal cord stimulation with the altered activity of intraspinal circuits associated with spinal spasticity. The main goal is to evaluate the validity of the chosen measures and to generate a data base for statistical planning of a subsequent clinical study.","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Leg Movement","Mental Health","Spasticity"],"st":[],"co":["Austria"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03886857"},{"n":"NCT07583277","t":"Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity","d":"The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups. Selective dorsal rhizotomy is well established effective procedure in participants with cerebral palsy associated spasticity. As low and middle income countries, intrathecal baclofen pump is expensive for patients.","s":"Not yet recruiting","tr":[],"o":["Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07583277"},{"n":"NCT06777576","t":"Self-balancing Personal Exoskeleton for SCI","d":"This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).","s":"Recruiting","tr":["Exoskeleton"],"o":["Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06777576","su":"https://scitrials.org/trial/NCT06777576"},{"n":"NCT06814015","t":"Self-balancing Personal Exoskeleton for SCI (Site 2)","d":"This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).","s":"Recruiting","tr":["Exoskeleton"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06814015","su":"https://scitrials.org/trial/NCT06814015"},{"n":"NCT07222033","t":"Self-balancing Personal Exoskeleton for SCI (WINY)","d":"This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).","s":"Recruiting","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07222033","su":"https://scitrials.org/trial/NCT07222033"},{"n":"NCT07536386","t":"Self-balancing Personal Exoskeleton for SCI (WIP)","d":"This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).","s":"Recruiting","tr":["Exoskeleton"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07536386","su":"https://scitrials.org/trial/NCT07536386"},{"n":"NCT05406258","t":"Self-Catheterization Mirror System for Female Patients","d":"The purpose of this study is to test a modified mirror system for female patients to use during self-catheterization.","s":"Completed","tr":["Devices"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05406258"},{"n":"NCT01606618","t":"Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury","d":"With improved life expectancy over the last fifty years, spina bifida has become a disease of the adult. One of the major stakes for these patients is the preservation of a regular follow-up of uro-nephrologicals risk factors and of a respect for the rules of self management of their neurological bladder. The main objective of this study is to highlight a difference in the level of global self-esteem among a population of adult patients with spina bifida and a population of adult patients with…","s":"Terminated","tr":["Observational"],"o":["Bladder Function","Mental Health"],"st":[],"co":["France"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01606618"},{"n":"NCT04540679","t":"Self-Management Across the Care Continuum","d":"Persons with spinal cord injury (SCI) face many challenges as they transition from inpatient care to outpatients and on into the community. With shorter lengths of stay and barriers to coordinating care between SCI specialists and community service providers, the development of self-management skills are an integral part in the effective community reintegration, proper healthcare utilization, management of secondary complications as well as independence and community participation. Based on the…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04540679","su":"https://scitrials.org/trial/NCT04540679"},{"n":"NCT05800717","t":"Self-Management Program for AIS D SCI","d":"About 25-51% of adults with acquired spinal cord injury (SCI) have \"AIS D\" SCI, the lowest severity grade of neurologic injury. Veterans with AIS D SCI generally have better outcomes in mobility, community integration, and employment. However, counterintuitively, they are also at higher risk of poor subjective well-being (SWB) and related psychosocial outcomes. Preliminary evidence suggests that poorer SWB in this group is associated with distinctive, modifiable factors such as less intensity…","s":"Withdrawn","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05800717"},{"n":"NCT06093074","t":"Self-management Program for Patients in the Sub-acute Phase After Traumatic Injury - a Feasibility Study","d":"The goal of this descriptive non-randomized feasibility study is to assess aspects of feasibility of the intervention arm in a planned full-scale randomized controlled trial testing the effectiveness of a self-management program for persons who have sustained a moderate to severe traumatic injury. All outcomes will be evaluated based on pre-defined success criteria. The main outcomes in the feasibility study are: * Consent rate of eligible patients * Drop-out rate * Attendance rate in the…","s":"Completed","tr":[],"o":[],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06093074"},{"n":"NCT00763282","t":"Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)","d":"Pressure ulcers (PrUs) are the most frequent significant medical complication after spinal cord injury (SCI). PrU prevalence, morbidity, mortality, and recurrence rates are high, and most persons with SCI will have at least one serious PrU during their lifetime. VA costs of treating the almost 3,500 unique Veterans with SCI and a severe ulcer at an SCI Center in FY10 was just under $400 million.","s":"Completed","tr":[],"o":[],"st":["California","Georgia","Illinois","Texas","Wisconsin"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00763282"},{"n":"NCT05200091","t":"Sensorimotor Integration Underlying Balance Control in Individuals With Incomplete Spinal Cord Injury","d":"The objectives of the study are to evaluate a 4-week mixed training paradigm consisting of explosive strength training and balance perturbation training efficacy on balance control during standing and locomotion, and to understand the mechanisms of neuroplasticity that would improve sensorimotor integration at supraspinal and spinal levels.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05200091","su":"https://scitrials.org/trial/NCT05200091"},{"n":"NCT01964261","t":"Sensory Motor Transformations in Human Cortex","d":"This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts along with sensory feedback. Development of a brain-machine interface is very difficult and currently only limited technology exists in this area of neuroscience. Other studies have shown that people with high…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["California","Colorado"],"co":["United States"],"lc":4,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT01964261","su":"https://scitrials.org/trial/NCT01964261"},{"n":"NCT01788969","t":"Serotonergic Modulation of Motor Function in Subacute and Chronic SCI","d":"The manifestation of weakness and involuntary reflexes following motor incomplete spinal cord injury (SCI) may be partly a result of damage to descending pathways to the spinal cord that release serotonin. In models of SCI, for example, application of agents that simulate serotonin has been shown to modulate voluntary motor behaviors, including augmentation of walking recovery. In humans following neurological injury, the effects of 5HT agents are unclear. Few previous reports indicate improved…","s":"Unknown","tr":["Drugs"],"o":["Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01788969","su":"https://scitrials.org/trial/NCT01788969"},{"n":"NCT02398331","t":"Sexual Health of Spinal Cord Injured Females","d":"The purpose of this study is to assess the impact on sexuality in women with a spinal cord injury, twelve months after their first return to home, of a program including structured information and education on sexuality, delivered 6 months after their first return to home.","s":"Completed","tr":[],"o":["Mental Health","Sexual Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02398331"},{"n":"NCT04315389","t":"SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study","d":"Robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries. These applications could provide direct benefits to patients in the clinical rehabilitation field. In this study, the feasibility of 2 CARE robot prototypes in facilitating dependent transfers and assisting patient mobility in their daily living activities will be studied.","s":"Completed","tr":["Devices","Observational","Rehabilitation","Surgical Procedure"],"o":["Trunk Control"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04315389"},{"n":"NCT04071938","t":"Shared Responsibility Between General Practitioners and Highly Specialized Hospitals in Spinal Cord Injury","d":"It is an interventional study that aims to assess a new primary care model of collaboration between specialized centers and primary care physicians in Switzerland, in order to reduce morbidity and improve patients' and providers' experience with delivery of follow-up care in individuals with chronic spinal cord injury as compared to current best practice.","s":"Unknown","tr":[],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04071938"},{"n":"NCT07501429","t":"Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury","d":"Approximately 305,000 people live with a spinal cord injury (SCI) in the United States. Sixty percent of these individuals have tetraplegia, which can cause significant dysfunction of the arms and hands. One of the consequences of SCI is spasticity - involuntary activation of muscles that can hinder bodily functions and negatively affect participation in various aspects of life. Spasticity can lead to loss of functional independence and activity limitations, cause pain, and lead to mood…","s":"Recruiting","tr":["Devices"],"o":["Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07501429","su":"https://scitrials.org/trial/NCT07501429"},{"n":"NCT05678803","t":"Short-Term Outcomes Of Subaxial Cervical Injuries","d":"The subaxial cervical spine consists of levels C3 through C7 and includes both the bony anatomy as well as the ligamentous anatomy. Injuries to the subaxial cervical spine can be bony, discoligamentous or a combination of both (1). Cervical spine trauma is common resulting from high energy trauma such as falling from height and motor vehicle accident (2). Devastating sequelae of subaxial cervical spine trauma include quadriplegia, functional loss, and permanent disability","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Egypt"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05678803"},{"n":"NCT05095454","t":"Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI","d":"A study comparing short-term delivery of epidural spinal stimulation versus transcutaneous spinal stimulation.","s":"Completed","tr":["Electrical Stimulation","Epidural Stimulation","Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Motor Function","Sexual Function","Spasticity","Trunk Control","Walking Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05095454"},{"n":"NCT07245706","t":"Shoulder Health After Rehabilitation and Performance Training","d":"The goal of this study is to investigate the impact of a home-based shoulder strength training on the overall shoulder health in manual wheelchair users, and if the timepoint of such a training makes a difference. The study is focusing on persons with a spinal cord injury in the thoracic or lumbar region of the spine, that have only recently been injured and will soon be discharged from primary rehabilitation. The shoulder training will take place either 3 or 12 months after discharge from…","s":"Recruiting","tr":["Devices"],"o":["Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07245706","su":"https://scitrials.org/trial/NCT07245706"},{"n":"NCT04712188","t":"Shoulder Kinematics and Acute Ultrasonographic Changes in Manual Wheelchair Users With Spinal Cord Injury","d":"People who lose function of the lower limb due to spinal cord injury (SCI) need to use their arms for activities of daily life especially during weight-bearing tasks, such as transfers, and manual wheelchair (MWC) propulsion in order to maintain mobility. Persistent use of the upper limbs constitutes biomechanical difficulties, especially in the shoulder joint. The most commonly affected area in the shoulder is supraspinatus and biceps tendon. Four different stoke patterns have been classified…","s":"Completed","tr":["Observational"],"o":["Leg Movement"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04712188"},{"n":"NCT04565925","t":"Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries","d":"The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries.","s":"Active, not recruiting","tr":[],"o":["Bladder Function"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04565925","su":"https://scitrials.org/trial/NCT04565925"},{"n":"NCT02946424","t":"Simvastatin to Prevent SCI-Induced Bone Loss","d":"This is a double blind, randomized, placebo -controlled clinical trial with the primary goal of determining the osteogenic benefits of simvastatin in acute SCI.","s":"Unknown","tr":[],"o":["Bone Strength"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02946424","su":"https://scitrials.org/trial/NCT02946424"},{"n":"NCT06117020","t":"Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals","d":"To assess the safety and tolerability of single and multiple doses of MTR-601 in normal healthy volunteers under fed and fasted conditions. To evaluate the plasma and urine pharmacokinetics (PK) of MTR-601. To evaluate the pharmacodynamic (PD) effects of MTR-601 on muscle strength and muscle accumulation of MTR-601 by muscle biopsy and other potential mechanistic, predictive and PD markers of MTR-601.","s":"Completed","tr":["Drugs","Safety"],"o":["Motor Function","Spasticity"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06117020"},{"n":"NCT03955523","t":"Single Exercise Session or Meal vs Control in SCI: Case Series","d":"The purpose of this study is to examine the immediate effects of a single exercise session or a high fat/high carbohydrate meal on the physical and mental health of people with a spinal cord injury (SCI). Specifically, we want to better understand the responses in people with SCI when they conduct exercise or eat an unhealthy meal, when looking at inflammation levels, the number and function of immune cells, brain function, pain and how one feels (affect). If we can understand these responses…","s":"Completed","tr":["Nutrition"],"o":["Mental Health","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03955523"},{"n":"NCT02916784","t":"Sit-to-stand in Spinal Cord Injury Patient","d":"1. Were there differences in functional ability between ambulatory individuals with SCI who passed and failed the independent sit-to-stand (iSTS) task? 2. Did the ability of iSTS relate to ability of walking as determined using a type of AAD used? 3. What were factors associated with the ability of iSTS?","s":"Completed","tr":["Observational"],"o":["Leg Movement","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02916784"},{"n":"NCT02913911","t":"Sit-to-stand With Feedback in SCI Patients","d":"* Does the utility of external feedback in terms of goal-directed LLL approach during STS training immediately improve functional ability relating to walking in ambulatory patients with SCI? * Does the utility of LLL feedback improve functional ability relating to walking in ambulatory patients with SCI after 2-week training?","s":"Completed","tr":[],"o":["Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02913911"},{"n":"NCT02660073","t":"Skeletal Muscle Hypertrophy and Cardio-Metabolic Benefits After Spinal Cord Injury","d":"Spinal cord injury (SCI) is a devastating medical problem that affects thousands of civilian and military personnel in the United States. Spinal cord injuries (SCI) predispose individuals to impaired fitness, obesity, glucose intolerance and insulin resistance, placing them at greater risk for diabetes and coronary artery disease. These are devastating problems that occur frequently because of changes in body composition and reduced level of physical activity. Skeletal muscle wasting plays a…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Neuromuscular Electrical Stimulation (NMES)","Rehabilitation"],"o":["Leg Movement","Quality of Life"],"st":["New York","Virginia"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02660073"},{"n":"NCT01962675","t":"Skilled Motor Training and tDCS to Improve Leg Function After Spinal Cord Injury","d":"The study investigates the effect of using transcranial direct current stimulation (tDCS) and skilled stepping training versus skilled stepping training with sham-tDCS in improving ankle and leg motor control in persons with ambulatory persons with spinal cord injury. Hypotheses H1: Participants will display greater improvement in stepping function following tDCS combined with training compared to sham-tDCS and training. H2: Participants will display greater gains in cortical excitability, as…","s":"Terminated","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Motor Function","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01962675"},{"n":"NCT02585765","t":"Skin Blood Flow Response to Insulin Iontophoresis in Pressure Ulcers of SCI","d":"Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces. As many as 85% of individuals with a spinal cord injury (SCI) report the occurrence of at least 1 PU since being injured. Despite the increasing attention and emphasis on prevention, PUs still represent a major health risk for persons with SCI. Among the numerous potential physical risk factors identified for the development of a PU…","s":"Withdrawn","tr":["Drugs","Nutrition"],"o":["Leg Movement","Pressure Sores"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02585765"},{"n":"NCT06195878","t":"Sleep Apnea in Paralympic Ontario-Resident aThletes With Spinal Cord Injury (SPORTS) Study","d":"This single arm clinical trial will assess whether continuous positive airway pressure (CPAP) therapy in the management of moderate-to-severe sleep-related breathing disorders (SRBDs) among para-athletes living with cervical/thoracic, complete or incomplete spinal cord injury (SCI) is effective in improving cognitive impairment, in reducing fatigue, depression, anxiety, and overall quality of life. Further, the study will evaluate the effectiveness of CPAP therapy in improving their performance…","s":"Unknown","tr":["Devices"],"o":["Breathing Function","Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06195878","su":"https://scitrials.org/trial/NCT06195878"},{"n":"NCT04161612","t":"Sleep Quality & Spinal Cord Injury","d":"The aim of the study was to evaluate sleep quality in patients with spinal cord injury; to investigate the relationship between sleep and spinal cord level, ambulation status, spasticity, quality of life, daily living activities, depressive status, neuropathic pain","s":"Completed","tr":["Observational"],"o":["Bladder Function","Mental Health","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04161612"},{"n":"NCT02176928","t":"Sleep-Disordered Breathing in Chronic SCI","d":"The purpose of this study is to examine impact of Sleep Disordered Breathing (SDB) treatment in persons with chronic Spinal Cord Injury (SCI). The central hypothesis is that the treatment of SDB with Positive Airway Pressure (PAP) will improve cognition, sleep quality, health related quality of life (HRQOL), pain and Cardiovascular Disease (CVD) surrogate measures in persons with chronic SCI.","s":"Completed","tr":["Devices"],"o":["Blood Pressure","Breathing Function","Pain Management","Quality of Life"],"st":["Florida","Michigan"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02176928"},{"n":"NCT05480618","t":"Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients","d":"This research will aid in understanding of slow-breathing and its effect on heart rate and blood pressure in people with a spinal cord injury (SCI). This research will investigate if traditional 'yogic' breathing exercises can be performed by subjects with SCI and its influence on the cardiovascular system.","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05480618"},{"n":"NCT07212725","t":"Solving SCI Pain: Pain Recovery Tools for SCI","d":"Brief Summary The goal of this clinical trial is to evaluate whether a neuroscience-informed, peer-led self-management program can promote behavior change and reduce pain interference in adults with spinal cord injury (SCI) and chronic pain. The primary aim is to support participants in developing practical, sustainable strategies for managing chronic pain through education, reflection, and consistent application of self-management tools. The program is designed to shift participants from…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Plasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07212725"},{"n":"NCT01241630","t":"Somato-sensory Reflex Arch in Spinal Cord Injury - Effect on Clinical Outcome","d":"Spinal cord injury (SCI) usually affects young people and causes severe bowel and bladder dysfunction. Recently, the concept of a surgically created somat-sensory reflex arch for bladder dysfunction in SCI has been introduced. The concept is promising, not just for bladder but also for bowel dysfunction. However, well designed studies need to be performed before recommending the procedure to a large number of patients worldwide. In this study we perform multidisciplinary studies providing…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01241630"},{"n":"NCT01274312","t":"Somato-sensory Reflex Arch in Spinal Cord Injury - Effect on Colorectal Transport","d":"Spinal cord injury (SCI) usually affects young people and causes severe bowel and bladder dysfunction. Recently, the concept of a surgically created somato-sensory reflex arch for bladder dysfunction in SCI has been introduced. The concept is promising, not just for bladder but also for bowel dysfunction. However, well designed studies need to be performed before recommending the procedure to a large number of patients worldwide. In this study the investigators perform multidisciplinary studies…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01274312"},{"n":"NCT02449512","t":"Somatosensory Evoked Potentials From the Lower Urinary Tract","d":"Spinal cord injury and other systemic neurological diseases (Multiple Sclerosis, Parkinson's disease) affect the integrity of lower urinary tract (LUT) function, leading to neurogenic lower urinary tract dysfunction (NLUTD). The urodynamic investigation is the current \"gold-standard\" for evaluating LUT function. Nevertheless, the sensory situation of the LUT cannot be investigated objectively. Furthermore, the current classification of the severity of the NLUTD due to spinal cord injury (SCI)…","s":"Withdrawn","tr":["Observational"],"o":["Bladder Function","Sensory Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02449512"},{"n":"NCT04241666","t":"Sonographic Examination of Renal Function in Individuals With Long-term Spinal Cord Injury","d":"Patients with long-term lower urinary tract dysfunction due to spinal cord injury presenting for a routine urodynamic control will be screened for inclusion and exclusion criteria. Suitable individuals providing written informed consent will undergo renal Doppler sonography and renal scintigraphy in addition to the routine examinations. Conclusions regarding renal function based on the clearance rate determined by scintigraphy (gold standard) will be compared with the conclusions based on…","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04241666"},{"n":"NCT01299792","t":"Sonographic Measurement of Bladder Wall Thickness in Patients With Neurogenic Bladder Dysfunction","d":"Video-urodynamic investigations are regarded as the current standard diagnostics for neurogenic bladder dysfunction in patients with spinal cord injury. This examination is exact, but time consuming, costly and associated with the risk of urinary tract infection. In patients with lower urinary tract symptoms due to benign prostate hyperplasia, sonographic measurement of bladder wall thickness has been demonstrated to be able to replace urodynamic testing for the diagnosis of infravesical…","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01299792"},{"n":"NCT03452007","t":"SPARC Bladder Mapping and Training Study","d":"The investigators propose to determine the electrode configurations that promote functional gains in the storage and voiding phases of lower urinary tract function as a result of activation of spinal circuits with spinal cord epidural stimulation in humans with spinal cord injury. The innovative approach and novel application of the Medtronic Specify 5-6-5 (16-electrode array) epidural device will allow the investigators to determine, with this early feasibility study, specific parameters of…","s":"Active, not recruiting","tr":[],"o":["Bladder Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03452007","su":"https://scitrials.org/trial/NCT03452007"},{"n":"NCT04393922","t":"Spasticity After Spinal Cord Injury","d":"Very often, people who have a SCI have difficulty doing things with their arms or hands as a result of muscle stiffness , or spasticity. Spastacity can cause problems performing even the simplest of everyday tasks. This research will help us understand how the body recovers and changes neurologically after SCI.","s":"Unknown","tr":["Brain Stimulation"],"o":["Spasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04393922","su":"https://scitrials.org/trial/NCT04393922"},{"n":"NCT06030531","t":"Spasticity and Functional Recovery After SCI","d":"Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood. Using electrophysiological and imaging techniques along with traditional measurements of neurological recovery in the acute rehabilitation setting including physical exam and functional assessments; the investigators aim to examine the relationship between development of…","s":"Unknown","tr":[],"o":["Spasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06030531","su":"https://scitrials.org/trial/NCT06030531"},{"n":"NCT07583498","t":"Spasticity in SCI Following Acute Intermittent Hypoxia","d":"This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":["Spasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07583498","su":"https://scitrials.org/trial/NCT07583498"},{"n":"NCT07397559","t":"Spatiotemporal tSCS in Spinal Cord Injury","d":"Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in muscle recruitment compared to invasive approaches limits the type of rehabilitation exercises that can be practiced. This project studies how spatial, frequency, and amplitude control of stimulation can be used to selectively target different neural pathways and…","s":"Recruiting","tr":["Observational","Transcutaneous Stimulation"],"o":["Leg Movement"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07397559","su":"https://scitrials.org/trial/NCT07397559"},{"n":"NCT01599767","t":"Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury","d":"The purpose of this study is to see the effects of transcranial direct current stimulation (tDCS) on the pain associated with spinal cord injury. This study is part of the Spaulding-Harvard Model System. The investigators hypothesize that there will be a decrease in pain levels with active stimulation, when compared to sham stimulation, using a 3 week stimulation schedule- 1 week of stimulation (5 consecutive days) followed by 2 weeks of stimulation (10 consecutive days) after a 3-month follow…","s":"Completed","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01599767"},{"n":"NCT04029974","t":"Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI","d":"This study seeks to evaluate whether the speed (cadence) of lower extremity robotic movement has an impact on orthostatic hypotension and upright tolerance when training with the ErigoPro robotic tilt-stepper. It is hypothesized more frequent short-lasting leg movements (faster cadence) reduces the occurrence/severity of orthostatic hypotension better than less frequent longer-lasting leg movements (slower cadence).","s":"Active, not recruiting","tr":[],"o":["Blood Pressure"],"st":["Mississippi"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04029974","su":"https://scitrials.org/trial/NCT04029974"},{"n":"NCT02833428","t":"Spinal Cord and Artificial Intelligence","d":"The aim of this study was to analyze using an artificial intelligence engine (IA) the influence of the pathophysiological environment (set parametric monitoring data, imaging, biology etc.) of acute spinal cord trauma on spinal pain. This project seeks to establish the principles of a new approach for studying spinal cord injury patients. It does not meet the usual criteria of clinical trials in so far as it does not test on patients the effect of a therapeutic","s":"Unknown","tr":[],"o":["Pain Management"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02833428","su":"https://scitrials.org/trial/NCT02833428"},{"n":"NCT05163639","t":"Spinal Cord Associative Plasticity Study","d":"Spinal cord associative plasticity (SCAP) is a combined cortical and spinal electrical stimulation technique developed to induce recovery of arm and hand function in spinal cord injury. The proposed study will advance understanding of SCAP, which is critical to its effective translation to human therapy. The purpose of the study is to: 1. Determine whether signaling through the spinal cord to the muscles can be strengthened by electrical stimulation. 2. Improve our understanding of the spinal…","s":"Recruiting","tr":[],"o":["Hand Movement"],"st":["New York"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT05163639","su":"https://scitrials.org/trial/NCT05163639"},{"n":"NCT00974168","t":"Spinal Cord Compression Re-Treat Study","d":"RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Radiation therapy may be effective in treating malignant spinal cord compression in patients who have received previous radiation therapy to the spine. PURPOSE: This phase II trial is studying radiation therapy in treating patients with malignant spinal cord compression.","s":"Completed","tr":[],"o":["Pain Management","Quality of Life"],"st":[],"co":["Ireland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00974168"},{"n":"NCT00968643","t":"Spinal Cord Compression. ICORG 05-03, V6","d":"RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known which radiation therapy schedule is more effective in treating patients with malignant spinal cord compression. PURPOSE: This randomized phase III trial is studying two different radiation therapy schedules to compare their side effects and how well they work in treating patients with malignant spinal cord compression.","s":"Completed","tr":[],"o":["Bladder Function","Pain Management","Quality of Life"],"st":[],"co":["Ireland"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00968643"},{"n":"NCT02537899","t":"Spinal Cord Injury - Assessing Tolerability and Use of Combined Rehabilitation and NeuroAiD","d":"SATURN investigates the promising role of NeuroAiD in patients with spinal cord injury and will provide important information on the feasibility of conducting larger controlled trials.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["Malaysia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02537899"},{"n":"NCT05376449","t":"Spinal Cord Injury - Exercise","d":"Long lasting inflammation in the body is related to cardiovascular and respiratory disease, which are the two most common causes of death in people living with spinal cord injury (SCI). Individuals with SCI have been reported to have higher levels of inflammation when compared to healthy individuals. Exercise is a well-known method to reduce inflammation; however, people with SCI are often inactive. The main goal of this study is to determine whether a 12-week adaptive exercise program can…","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05376449"},{"n":"NCT02026167","t":"Spinal Cord Injury Collaborative Care Study","d":"The objective of this study is to test the effectiveness of a collaborative care approach to improving outpatient treatment for inactivity, chronic pain and depression as a way of improving overall Quality of Life for patients with SCI.","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02026167"},{"n":"NCT01184365","t":"Spinal Cord Injury Energy Management Program","d":"Fatigue is a common complaint of persons with spinal cord injury (SCI) that negatively affects physical function, participation in daily activities, employment, and community involvement. No behavioural intervention for fatigue has been reported for SCI, though the benefits of such programs have been proven in persons with neurological conditions like multiple sclerosis and arthritis. Based on a study with people with SCI, an energy management program (EnMP-1) was developed. The focus of this…","s":"Completed","tr":["Surgical Procedure"],"o":["Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01184365"},{"n":"NCT02592668","t":"Spinal Cord Injury Epidural Stimulation","d":"This is a feasibility study to test the use of epidural stimulation to restore volitional function previously lost due to spinal cord injury. Previous studies conducted in animal models, performed elsewhere and here at Mayo Clinic, have shown that direct electrical stimulation of the spinal cord increases the excitability of spared neuronal connections within the site of injury, thereby enhancing signal transmission and allowing recovery of previously lost volitional function. Recently…","s":"Completed","tr":["Devices","Electrical Stimulation","Epidural Stimulation","Rehabilitation"],"o":["Bladder Function","Bone Strength","Bowel Function","Mental Health","Quality of Life","Sexual Function","Spasticity","Temperature Control","Trunk Control","Walking Function"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02592668"},{"n":"NCT03495986","t":"Spinal Cord Injury Exercise and Nutrition Conceptual Engagement","d":"Evaluate and compare the health benefits of an at home exercise program using functional electrical stimulation (FES) for lower extremity exercise with diet versus a diet alone group in adults with spinal cord injury.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Nutrition"],"o":["Bone Strength","Leg Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03495986"},{"n":"NCT04117854","t":"Spinal Cord Injury in the Pediatric Population - an International Multicenter Study","d":"INTRODUCTION: Due to the low incidence of pediatric spinal cord injury (SCI) and the high demand for knowledge and research, international cooperation is needed to build a solid and shared understanding of the extent of the problem, and also uniformity in treatment and measurement methods. The aim of the study is to map organization of care and rehabilitation of children and adolescents \\< 18 years of age with SCI, to explore qualitatively psychosocial aspects of individuals and to establish…","s":"Unknown","tr":["Observational"],"o":[],"st":["New York"],"co":["Australia","China","Israel","Norway","Palestinian Territories","Russia","Sweden","United States"],"lc":11,"rlc":10,"cu":"https://clinicaltrials.gov/study/NCT04117854","su":"https://scitrials.org/trial/NCT04117854"},{"n":"NCT01498991","t":"Spinal Cord Injury Leg Rehabilitation","d":"The purpose of this study is to determine if individuals with incomplete spinal cord injury (SCI) who remain unable to walk normally 1 year after their SCIs are able to sense and move the affected legs better after 10-13 weeks of treatment with a new robotic therapy device. The hypothesis is that using the AMES device on the legs of chronic subjects with incomplete SCI will result in improved strength, sensation in the legs, and improved functional gait in the treated limbs.","s":"Terminated","tr":["Devices","Rehabilitation"],"o":["Motor Function","Sensory Function","Spasticity","Walking Function"],"st":["Georgia","Oregon"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01498991"},{"n":"NCT04972773","t":"Spinal Cord Injury Mental Health Functional Outcomes Improved by Mindfulness","d":"Recovery from injury is an immune function but also involves stress. Spinal cord injury (SCI) patients are one population with a difficult recovery journey. Improvements in SCI rehabilitation could benefit patient's recovery and decrease their functional limitations. Lack of independence and chronic pain contributes to a higher rate of mental health problems (48.5%) and clinical stress (25%) in SCI patients. Depression is more common among auto-immune phenotypes and depression patients have…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04972773"},{"n":"NCT06003686","t":"Spinal Cord Injury Model Systems (SCIMS) - Education Module","d":"The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["District of Columbia","Florida","Texas"],"co":["United States"],"lc":3,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06003686","su":"https://scitrials.org/trial/NCT06003686"},{"n":"NCT05426681","t":"Spinal Cord Injury Neuroprotection With Glyburide","d":"To assess the safety and efficacy of using oral Glyburide (Diabeta) as a neuroprotective agent in patients with acute cervical or thoracic traumatic spinal cord injury.","s":"Recruiting","tr":["Safety"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05426681","su":"https://scitrials.org/trial/NCT05426681"},{"n":"NCT02524379","t":"Spinal Cord Injury Neuroprotection With Glyburide","d":"The purpose of this study is to determine the safety of using oral Glyburide in patients with acute traumatic cervical spinal cord injuries (SCI).","s":"Terminated","tr":["Drugs"],"o":[],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02524379"},{"n":"NCT06871254","t":"Spinal Cord Injury Neurorecovery Collaboration","d":"SCINC is an adaptive design Master protocol that seeks to determine if there is \"sufficient promise\" of beneficial effect of treatment combinations to enhance motor recovery in pre-specified strata of people with a spinal cord injury.","s":"Recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Breathing Function","Hand Movement"],"st":[],"co":["Australia"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06871254","su":"https://scitrials.org/trial/NCT06871254"},{"n":"NCT03925077","t":"Spinal Cord Injury Program in Exercise","d":"The purpose of this study is to examine two 8-week, remotely delivered exercise interventions: Movement-to-Music (M2M) and Standard Exercise Training (SET), with 327 adults with spinal cord injury. Enrolled participants will be randomized into one of three groups: a) M2M, b) SET, and c) attention control (AC).","s":"Completed","tr":["Rehabilitation"],"o":["Pain Management","Quality of Life"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03925077"},{"n":"NCT00178724","t":"Spinal Cord Injury Registry - North American Clinical Trials Network","d":"The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological…","s":"Recruiting","tr":["Observational","Rehabilitation"],"o":[],"st":["Florida","Kentucky","Louisiana","Maryland","North Carolina","Pennsylvania","Tennessee","Texas","Virginia","Wisconsin"],"co":["Canada","United States"],"lc":14,"rlc":8,"cu":"https://clinicaltrials.gov/study/NCT00178724"},{"n":"NCT01421394","t":"Spinal Cord Injury Series of Tampere - Retrospective Study","d":"This prospective study will assess thoroughly functional deficits and their significance in the light of rehabilitation in spinal cord injured patients.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Finland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01421394","su":"https://scitrials.org/trial/NCT01421394"},{"n":"NCT02876666","t":"Spinal Cord Injury Virtual Coach RCT","d":"The SCI Virtual Coach study has developed an on-screen, human-like character that will provide support, education and coaching to adults with spinal cord injury (SCI) to aid in the prevention of serious secondary conditions like pressure ulcers. In a randomized controlled trial, participants assigned to \"the Coach\" intervention will have a touch-screen computer placed in their homes and be asked to interact with the Coach on a daily basis for 2 months. Participants will be asked to complete…","s":"Completed","tr":[],"o":[],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02876666"},{"n":"NCT00117806","t":"Spinal Cord Injury Vocational Integration Program (SCI-VIP)","d":"This study involves research about how to help Veterans with spinal cord injury (SCI) gain employment. During the first couple of years following SCI, many people are concentrating on their rehabilitation and are unable to afford the time for return to work. However, studies have shown people often regain the necessary strength and function about two years after SCI to resume activities of daily living very similar to what they experienced prior to the SCI. Even though many social and legal…","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function"],"st":["Florida","Missouri","Ohio","Texas"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00117806"},{"n":"NCT00987155","t":"Spinal Cord Injury: Endurance, Strength and Cardiac Function Induced by Efficient Training Protocols","d":"1. Measurements of peak oxygen uptake (VO2peak) during passive leg cycling (PLC) combined with arm crank ergometry (ACE), leg vascular occlusion (100mmHg above systolic BP) combined with ACE, and FES isometric contractions combined with ACE in spinal cord injured (SCI). All the above mentioned parameters will be compared to Functional Electrical Stimulated (FES) lower extremity cycling combined with ACE (FEShybrid). The hypothesis is that VO2peak is significantly higher during FES hybrid…","s":"Completed","tr":["Functional Electrical Stimulation (FES)"],"o":["Blood Pressure","Leg Movement","Motor Function"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00987155"},{"n":"NCT06887309","t":"Spinal Cord Injury: Impact on Sensory, Motor, Behavioral and Cognitive Functions","d":"Spinal cord injury (SCI) causes a variety of sensory-motor deficits and neuropsychological consequences. Magnetic resonance imaging (MRI) reveals a reduction in the volume of the somato-sensory and motor cortices, as well as atrophy in the white matter bundles. In addition, disturbances in cerebral activity are observed in several areas, notably the motor cortex and the prefrontal cortex. The aim of this study is to understand the evolution of brain function after SCI in comparison with a…","s":"Not yet recruiting","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06887309"},{"n":"NCT02313194","t":"Spinal Cord Neuromodulation for Spinal Cord Injury","d":"This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.","s":"Active, not recruiting","tr":["Epidural Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02313194","su":"https://scitrials.org/trial/NCT02313194"},{"n":"NCT05301335","t":"Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE \"CONTINENCE\" Clinical Study","d":"The purpose of this study is to evaluate the effectiveness and safety of SCONE neuromodulation therapy after 12 weeks of therapy in comparison to inactive sham control in improving symptoms of Neurogenic Lower Urinary Tract Dysfunction","s":"Completed","tr":["Electrical Stimulation"],"o":["Bladder Function"],"st":["California","Colorado","District of Columbia","Florida","Georgia","Massachusetts","Minnesota","New York","North Carolina"],"co":["Canada","India","United States"],"lc":12,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05301335"},{"n":"NCT04894734","t":"Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)","d":"The purpose of this feasibility study is to compare the impact of Spinal cord stimulation \\[SCS\\] for Spinal Cord Injury (SCI) pain and rehabilitation. SCS, also known as Epidural Electrical Stimulation (EES), will be utilized along with conventional medical management (CMM) or CMM alone. Participation in this research study is expected to last approximately 24 months. All subjects will be evaluated and proceed with implantation of two SCS devices- one tailored based on the individual's SCI for…","s":"Active, not recruiting","tr":["Epidural Stimulation"],"o":["Pain Management"],"st":["North Carolina"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04894734","su":"https://scitrials.org/trial/NCT04894734"},{"n":"NCT03924388","t":"Spinal Cord Stimulation and Autonomic Response in People With SCI.","d":"Despite being studied less than half as frequently, autonomic dysfunction is a greater priority than walking again in spinal cord injury. One autonomic condition after spinal cord injury is orthostatic hypotension, where blood pressure dramatically declines when patients assume the upright posture. Orthostatic hypotension is associated with all-cause mortality and cardiovascular incidents as well as fatigue and cognitive dysfunction, and it almost certainly contributes to an elevated risk of…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03924388","su":"https://scitrials.org/trial/NCT03924388"},{"n":"NCT05178056","t":"Spinal Cord Stimulation and Respiration After Injury","d":"Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care. Respiratory function in patients with chronic spinal cord injury can be improved by using inspiratory-expiratory pressure threshold respiratory training protocol. However, the effectiveness of this intervention is limited…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Breathing Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05178056","su":"https://scitrials.org/trial/NCT05178056"},{"n":"NCT05472584","t":"Spinal Cord Stimulation and Training","d":"This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":[],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05472584","su":"https://scitrials.org/trial/NCT05472584"},{"n":"NCT05926843","t":"Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury","d":"Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with spinal cord injury (SCI). The investigators will enroll ten research participants with clinically incomplete/complete SCI (patients with paraplegia or severe paraparesis) who will undergo SCS subsequently assisted by motor rehabilitation training for restoring motor function at IRCCS Ospedale San Raffaele, Milan…","s":"Completed","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05926843","su":"https://scitrials.org/trial/NCT05926843"},{"n":"NCT07412808","t":"Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study","d":"Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI). The investigators will enroll ten research participants with clinically incomplete/complete SCI (patients with paraplegia or severe paraparesis) who will undergo SCS subsequently assisted by motor rehabilitation training for restoring motor function at IRCCS Ospedale San…","s":"Not yet recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07412808","su":"https://scitrials.org/trial/NCT07412808"},{"n":"NCT07153536","t":"Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis","d":"This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke. The spinal cord stimulation (SCS) will be combined with physical training to improve arm and hand motor control. The study is divided into three phases. In the first phase, after baseline assessments, participants will undergo a Physical Training Protocol (PTP) for 6 weeks including 3 sessions of 90…","s":"Recruiting","tr":["Devices","Electrical Stimulation","Rehabilitation"],"o":["Arm Movement","Motor Function","Spasticity"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07153536"},{"n":"NCT06540859","t":"Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI","d":"This study is a randomized, single-blind, two-arm sham-controlled clinical trial to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) over the lower thoracic and upper lumbar spinal cord segments for cardiovascular function in adults (21-65 years old) with cervical and upper thoracic spinal cord injury (SCI) (≥T6) AIS A-D during inpatient rehabilitation and outpatient visits within three months after the onset. We will recruit 26 individuals with SCI, admitted to…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":[],"st":["Washington"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06540859","su":"https://scitrials.org/trial/NCT06540859"},{"n":"NCT05157282","t":"Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia","d":"In support of the long-term goal of developing new strategies to increase limb function after SCI, the objectives of this proposal are to: 1) Examine the behavioral and physiological effects of TESS on upper-limb muscles after cervical SCI; and 2) Maximize the recovery of reaching and grasping potential by using tailored TESS in a task-specific manner with motor training. Veterans with cervical spinal injuries and healthy volunteers will be recruited for this study.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["Illinois"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05157282","su":"https://scitrials.org/trial/NCT05157282"},{"n":"NCT06438991","t":"Spinal Cord Stimulation for Lower Extremity Function","d":"This prospective clinical study will investigate the ability of different spine imaging characteristics to predict ambulation recovery responsiveness using epidural spinal cord stimulator (SCS) in patients with chronic incomplete spinal cord injury (SCI). Epidural spinal cord stimulation below the level of injury can restore previously lost lower extremity voluntary motor function for some patients. The goal of this study is to establish whether spine imaging can be utilized as a biomarker to…","s":"Not yet recruiting","tr":["Epidural Stimulation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06438991","su":"https://scitrials.org/trial/NCT06438991"},{"n":"NCT06019949","t":"Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury","d":"Respiratory complications are among the leading causes of death in patients with chronic spinal cord injury (SCI). Our previous work showed that pulmonary function can be improved by using our original respiratory training method. However, the effectiveness of this intervention is limited due to the disruption of brain-spinal connections and consequently lowered spinal cord activity below the injury level. Our recent studies showed that electrical stimulation of the spinal cord below the level…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Breathing Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06019949","su":"https://scitrials.org/trial/NCT06019949"},{"n":"NCT05433064","t":"Spinal Cord Stimulation for Spinal Cord Injury Patients - Regain Walk and Alleviate Pain","d":"The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.","s":"Completed","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05433064","su":"https://scitrials.org/trial/NCT05433064"},{"n":"NCT03702010","t":"Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase","d":"Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area. Several parameters are set to maximize the overexposure zone, such as frequency,and pulse width. Although this technique has improved pain in many patients, paresthesia itself can be uncomfortable. Traditionally, the occurrence of paresthesias has been considered to be a predictor of success in pain elimination, while the non-occurrence of paresthesias would…","s":"Completed","tr":["Devices","Drugs","Electrical Stimulation","Surgical Procedure"],"o":["Pain Management","Sensory Function"],"st":[],"co":["Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03702010"},{"n":"NCT03240601","t":"Spinal Cord Stimulation to Augment Activity Based Therapy","d":"Involuntary muscle activity, often called spasticity, is a common problem following spinal cord injury (SCI) that can make it hard to move. Many things can cause spasticity including: muscle stretch, movement, or it can happen for no reason, and it is often described as an uncontrolled muscle spasm or feeling of stiffness. Drugs are typically used to treat spasticity, but they often have side effects, like muscle weakness, which can add to movement problems. Rehabilitation therapies offer…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Quality of Life","Spasticity","Walking Function"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03240601"},{"n":"NCT00116337","t":"Spinal Cord Stimulation to Restore Cough","d":"The purpose of this trial is to determine the efficacy of spinal cord stimulation to produce an effective cough in patients with spinal cord injuries.","s":"Completed","tr":["Electrical Stimulation"],"o":["Breathing Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00116337"},{"n":"NCT05731986","t":"Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)","d":"The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury). Blood pressure instability, specifically orthostatic hypotension (a drop in blood pressure when moving lying flat on your back to an upright position), appears early after the injury and often significantly interferes with participation in the critical rehabilitation time period. The main questions it…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05731986","su":"https://scitrials.org/trial/NCT05731986"},{"n":"NCT06243211","t":"Spinal Decompression Plus Nerve Graft Implantation Following TSCI","d":"This is a single-blinded (with outcome assessors blinded to treatment allocation), 12-month pilot study to evaluate of the safety, feasibility, and preliminary efficacy of dorsal myelotomy and expansive duraplasty performed either without or with autologous nerve graft implantation after acute traumatic spinal cord injury. Ten participants will be allocated to receive either DMED (n=5) or DMED + ANGI (n=5) based on a block design. Participants and assessors will be blinded to group allocation…","s":"Recruiting","tr":[],"o":["Regeneration"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06243211","su":"https://scitrials.org/trial/NCT06243211"},{"n":"NCT07222046","t":"Spinal Neurorehabilitation for Veterans With SCI","d":"Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, electrical spinal neuromodulation has emerged as a potential approach to restore voluntary motor function and locomotion in persons with chronic SCI. However, spinal neuromodulation has yet to…","s":"Recruiting","tr":["Epidural Stimulation","Rehabilitation"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07222046","su":"https://scitrials.org/trial/NCT07222046"},{"n":"NCT07683780","t":"Spinal Stimulation + FES-Assisted Cough Training in SCI","d":"The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective intervention to improve cough strength and coordination in individuals with acute/subacute SCI.","s":"Enrolling by invitation","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Transcutaneous Stimulation"],"o":["Breathing Function","Motor Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07683780"},{"n":"NCT05522920","t":"Spinal Stimulation for Chronic Complete Tetraplegia","d":"The purpose of this study is investigate the acceptability and effectiveness of transcutaneous spinal cord stimulation in people with complete high level spinal cord injury.","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Hand Movement"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05522920","su":"https://scitrials.org/trial/NCT05522920"},{"n":"NCT06743607","t":"Spinal Stimulation for Upper Extremity Recovery in the Home","d":"The purpose of this research is to evaluate the safety, feasibility, and tolerability of non-invasive spinal stimulation used in the home and/or community in combination with a functional home exercise program for the upper extremities (arm/hand function) as well as their combined impacts on changes in upper extremity function. The expected duration of participation in this study is about 31-33 hours over a 13-25-week period. Enrollees in this study will be randomly assigned to one of two…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06743607","su":"https://scitrials.org/trial/NCT06743607"},{"n":"NCT04132596","t":"Spinal Stimulation in Chronic Spinal Cord Injury","d":"Electrical spinal stimulation combined with activity-based rehabilitation (ABR) can improve motor and autonomic function in individuals suffering from varying degrees of paralysis. Spinal stimulation studies have included invasive implanted devices and non-invasive transcutaneous systems using different combinations of stimulation current, waveform, amplitude, duration and spinal levels targeted. Invasive and non-invasive systems have been demonstrated to permit individuals with chronic spinal…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Breathing Function","Hand Movement","Motor Function","Quality of Life","Sensory Function","Spasticity","Trunk Control"],"st":[],"co":["United Kingdom"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04132596"},{"n":"NCT03536338","t":"Spinal Stimulation Sit-to-Stand Training After Spinal Cord Injury","d":"An injury to the spinal cord can be life altering: with a 'complete' injury, the affected individual is unable to move their legs at all and may become wheelchair-bound. While a 'complete' injury suggests that the cord was completely severed, it is actually more common for some connections in the spinal cord to remain after it is injured but, for some reason, they are inactive or sleeping. Electrical stimulation applied to the skin surface at the lower back appears to 'wake up' these remaining…","s":"Terminated","tr":["Electrical Stimulation"],"o":["Bladder Function","Leg Movement","Mental Health","Motor Function","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03536338"},{"n":"NCT07375745","t":"Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury","d":"Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\\< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation. Standard care in rehabilitation centers relies on activity-based therapy (ABT), which uses intensive, task-specific training to promote recovery. Although ABT can improve mobility, its effects are often limited due to the nature of SCI…","s":"Not yet recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07375745","su":"https://scitrials.org/trial/NCT07375745"},{"n":"NCT06867809","t":"Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury","d":"Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury. While some scientists have begun to study the effect of electrical stimulation on patient's ability to walk and move their legs after lower spinal cord injury, the use of stimulation of the upper (cervical) spine to restore arm and hand function after cervical spinal cord injury remains less well explored. The investigators are doing this research…","s":"Recruiting","tr":["Brain Stimulation","Epidural Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["New York"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06867809","su":"https://scitrials.org/trial/NCT06867809"},{"n":"NCT01826058","t":"Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression","d":"Metastatic epidural spinal cord compression (MESCC) is a frequent oncologic emergency that requires to be treated promptly. Although direct decompressive surgery is the most effective treatment, surgery is only used in selected patients because most patients have a poor overall condition and short life expectancy. Radiation therapy (RT), therefore, is the most commonly used for patients with MESCC, but conventional RT alone can achieve modest neurologic outcomes. The hypothesis to use…","s":"Unknown","tr":["Epidural Stimulation","Surgical Procedure"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01826058"},{"n":"NCT03709095","t":"Sprint Interval Training During Rehabilitation After Spinal Cord Injury","d":"Immediately following a spinal cord injury (SCI), patients are admitted to inpatient rehabilitation where they undergo physical reconditioning in preparation for a return to home setting. The current standard of practice for aerobic training is performing arm-ergometry for 25 mins at a frequency of three times per week. Given the move towards shortened length of stay during inpatient rehabilitation, performing MICT can consume a considerable amount of therapy time. Sprint interval training…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03709095"},{"n":"NCT04123847","t":"Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation","d":"This study will determine the level of functional gain, below the injury for voluntary control of movements, and recovery standing and stepping function as a result of activation of spinal circuits with scES in humans with severe paralysis. Training will consist of practicing stepping, standing and voluntary movements in the presence of specific scES configurations designed specific for stepping (Step-scES), specific for standing (Stand-scES) and for the voluntary movements of the legs and…","s":"Active, not recruiting","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04123847","su":"https://scitrials.org/trial/NCT04123847"},{"n":"NCT03113994","t":"Statin Monotherapy for Treatment of Endocrine Metabolic Disease Risk","d":"Rationale: After having a spinal cord injury (SCI), people develop changes in their body composition that influences their long-term health. Individuals with paralysis after SCI will have large declines in their bone density ant increases in fat mass which increases their risk of fracture and heart disease. Therapies to prevent SCI-related changes in body composition and their health effects are needed. Drugs known as \"statins\" used often to reduce high cholesterol, may help to reduce bone loss…","s":"Terminated","tr":["Drugs","Nutrition"],"o":["Bone Strength"],"st":["Florida"],"co":["Canada","United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03113994"},{"n":"NCT03225625","t":"Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study","d":"The SciExVR study will evaluate the potential benefit of autologous bone marrow derived stem cells (BMSC) in the treatment of spinal cord injury with evidence of impaired motor or sensory function. The treatment consists of bilateral paraspinal injections of the BMSC at the level of the injury as well as superior and inferior to that spinal segment followed by an intravenous injection and intranasal placement. Patients undergoing BMSC treatment may also be assigned to use of exoskeletal…","s":"Unknown","tr":["Drugs","Exoskeleton","Stem Cells"],"o":["Mental Health","Sensory Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03225625"},{"n":"NCT02009124","t":"Stem Cell Therapy in Spinal Cord Injury","d":"The purpose of this study is to study the effect of stem cell therapy on common symptoms in patients with spinal cord injury.","s":"Withdrawn","tr":["Stem Cells"],"o":["Quality of Life"],"st":[],"co":["India"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02009124"},{"n":"NCT03935724","t":"Stem Cells in Spinal Cord Injury","d":"This is a multicenter, randomized, double-blind, placebo-controlled and delayed-start phase II/III clinical study.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["Denmark","Spain"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03935724","su":"https://scitrials.org/trial/NCT03935724"},{"n":"NCT03254797","t":"Stepping Training Using External Feedback in Spinal Cord Injury Patients","d":"Does a 4-week stepping training program with or without external feedback clinically change functional ability and reduce risk of fall of ambulatory patients with iSCI? Are there significant differences between 4-weeks stepping training with or without external feedback in ambulatory patients with iSCI?","s":"Completed","tr":[],"o":["Leg Movement","Motor Function","Walking Function"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03254797"},{"n":"NCT03529708","t":"Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression","d":"Spinal cord compression (SCC) is a devastating complication of advanced malignancy, and can cause significant deterioration in function and quality of life (QoL). The goal of treatment is to improve functional status and symptoms, but the optimal treatment regimen for these patients has not been thoroughly established. Many patients with SCC present with uncontrolled systemic disease and poor performance status, and are not eligible for standard surgical resection. They are generally treated…","s":"Unknown","tr":["Safety","Surgical Procedure"],"o":["Motor Function","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03529708"},{"n":"NCT02167633","t":"Stereotactic Radiosurgery in Metastatic Spinal Cord Compression","d":"To determine whether stereotactic radiosurgery of metastatic spinal cord compression is equivalent to decompressive surgery followed by external body radiation therapy to maintain ability to walk at 6 weeks.","s":"Terminated","tr":["Drugs","Surgical Procedure"],"o":["Bladder Function","Pain Management","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02167633"},{"n":"NCT07656883","t":"Stereotactic Radiotherapy for SPinal Metastases With Limited Extent of Epidural Disease","d":"This study evaluates a new radiation treatment approach for patients with cancer that has spread to the spine (vertebral metastases) and involves limited extension around the spinal cord without causing compression (non-compressive epiduritis). This condition is common and can lead to serious complications, including pain and spinal cord compression, potentially affecting mobility and quality of life. The current standard of care is conventional radiotherapy, which is effective for symptom…","s":"Not yet recruiting","tr":[],"o":["Pain Management","Quality of Life"],"st":[],"co":["France"],"lc":14,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07656883"},{"n":"NCT02936453","t":"STIMO: Epidural Electrical Simulation (EES) With Robot-assisted Rehabilitation in Patients With Spinal Cord Injury.","d":"STIMO is a First-in-Man (FIM) study to confirm the safety and feasibility of a closed-loop Epidural Electrical Stimulation (EES) in combination with overground robot assisted rehabilitation training for patients with chronic incomplete spinal cord injury (SCI). Patients will participate during 8-12 months, during which there will be: * Pre-implant evaluations (6-8 weeks) * Device implantation and stimulation optimization (6-8 weeks) * Overground rehabilitation training with EES (5-6 months). In…","s":"Completed","tr":["Epidural Stimulation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02936453","su":"https://scitrials.org/trial/NCT02936453"},{"n":"NCT06078176","t":"Stimulation for Bowel Emptying","d":"The investigators are testing the effect of electrical stimulation of the rectum on colonic motility. Most individuals with spinal cord injury develop neurogenic bowel dysfunction, which includes slowed colonic motility, which means that stools take longer than normal to pass through the colon. This slowed movement may result in chronic constipation and difficulty emptying the bowels. Individuals typically (without or without caregiver assistance) insert a gloved finger into the rectum and…","s":"Recruiting","tr":[],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06078176","su":"https://scitrials.org/trial/NCT06078176"},{"n":"NCT03702842","t":"Stimulation to Enhance Walking Post-SCI","d":"This pilot study will investigate the effects of transcutaneous direct current stimulation (tsDCS) on walking function in individuals with incomplete spinal cord injury. Following rehabilitation, individuals with ISCI often demonstrate improved walking function, but continue to have serious impairments that limit mobility, community participation and quality of life. Adjuvants to rehabilitation that increase spinal excitation during training may enhance its effectiveness. tsDCS is a…","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)","Transcutaneous Stimulation"],"o":["Quality of Life","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03702842"},{"n":"NCT01659541","t":"Stimulation With Wire Leads to Restore Cough","d":"The purpose of this trial is to determine the efficacy of spinal cord stimulation, using wire leads, to produce an effective cough in patients with spinal cord injuries.","s":"Completed","tr":["Devices","Electrical Stimulation"],"o":["Breathing Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01659541"},{"n":"NCT05777941","t":"Strength Training With Eccentric Arm-cranking in Para-athletes","d":"The new training device, the eccentric arm-crank, will be examined for its training effects in athletes with a spinal cord injury (SCI) by this project. That the training device can be used in patients with paraplegia in the future, the so-called \"testing of the applicability of this concept\" will be carried out during this study. Fourteen volunteer, healthy athletes with SCI are first tested for their upper body performance, followed by a training phase over 20 trainings and at the end the…","s":"Completed","tr":["Devices"],"o":["Hand Movement","Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05777941"},{"n":"NCT03437850","t":"Strengthening Health Systems for Persons With Traumatic Spinal Cord Injury in South Africa and Sweden","d":"A traumatic spinal cord injury (TSCI) often causes an unprecedented change in functioning by altering bodily structure and function. More specifically, the direct consequences of TSCI to the motor, sensory and autonomic nervous system not only challenge an individual's independency but also the ability to make a positive adjustment to life after injury. In line with this, TSCI survivors often experience threats to their livelihood and becoming integrated members of society. Health systems…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["South Africa"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03437850","su":"https://scitrials.org/trial/NCT03437850"},{"n":"NCT02177929","t":"Study About Acting of Adaptive Sport in Musculoskeletal, Cardiovascular System and the Quality of Life of Individuals With Spinal Cord Injury Through Biomedical Instrumentation","d":"The hypothesis is to the fulfillment of canoeing, handbike and conventional physiotherapy activities the groups could show improvement in muscle strength of the arms, decreased resistance of the lower limbs (spasticity), improved trunk balance and movements of the upper limbs, improves cardiovascular function, bone health, and consequently improve the quality of life.","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength","Motor Function","Spasticity"],"st":[],"co":["Brazil"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02177929","su":"https://scitrials.org/trial/NCT02177929"},{"n":"NCT01272336","t":"Study Effects of Intermittent Hypoxia on Restoring Hand Function Following SCI","d":"The goal of the study is to examine the effects of repeated breathing episodes of mild intermittent hypoxia (reduced oxygen) training on hand strength and grasping ability following cervical spinal injury, and to determine whether these changes result in improved hand function. If so, such changes may indicate hypoxia-induced spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences), which could result in improvements in hand use for persons with…","s":"Completed","tr":["Drugs","Intermittent Hypoxia"],"o":["Breathing Function","Hand Movement","Motor Function","Plasticity"],"st":["Georgia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01272336"},{"n":"NCT04300491","t":"Study Examines the Feasibility, Safety and Benefits of Using a Specific Suspension Walking Device for Patients With Neurological Damage","d":"This monocentric descriptive study addresses feasibility, safety and benefits of using a specific suspension walking device for patients with severe neurological injuries in the neuroICU of Montpellier University Hospital, France. Analyzes are retrospective on data collected prospectively during standard practice. All adult neurological patients hospitalized for \\> 48 hours and requiring mechanical ventilation from January 2018 to January 2019 are included, and divided into two groups…","s":"Completed","tr":["Devices","Observational"],"o":["Blood Pressure","Breathing Function","Pain Management","Walking Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04300491"},{"n":"NCT00004445","t":"Study of an Implantable Functional Neuromuscular Stimulation System for Patients With Spinal Cord Injuries","d":"OBJECTIVES: I. Establish the procedures for implementing and assessing the clinical utility of functional neuromuscular stimulation using an implanted eight-channel standing and transfer system in patients with incomplete tetraplegia or paraplegia. II. Develop and apply quantitative functional evaluations of system performance in these patients. III. Perform long term follow up and monitor system use outside of the laboratory.","s":"Completed","tr":["Devices","Surgical Procedure"],"o":[],"st":["Ohio"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00004445"},{"n":"NCT00512148","t":"Study of Autologous Neo-Bladder Construct in Subjects With Neurogenic Bladder Following Spinal Cord Injury","d":"Subjects with neurogenic bladder secondary to spinal cord injury that is refractory to medical treatment and requires augmentation cystoplasty will be enrolled. The hypothesis is that augmentation cystoplasty using an autologous neo-bladder construct will reduce maximum detrusor pressure.","s":"Terminated","tr":["Devices"],"o":["Bladder Function"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00512148"},{"n":"NCT00004415","t":"Study of Combined Intercostal and Diaphragm Pacing for Artificial Respiration in Quadriplegic Patients","d":"OBJECTIVES: I. Determine whether combined intercostal muscle and diaphragm pacing can maintain full-time ventilatory support in patients with ventilatory dependent quadriplegia who are not candidates for phrenic nerve pacing alone. II. Evaluate the efficacy of the Medlink device to produce synchronous intercostal and diagram activation in these patients.","s":"Terminated","tr":["Devices"],"o":["Breathing Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00004415"},{"n":"NCT00330759","t":"Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.","d":"The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple myeloma (excluding breast and prostate cancer)","s":"Completed","tr":["Drugs"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00330759"},{"n":"NCT07680361","t":"Study of Home Use of the Jaco Robotic Manipulation Device by Individuals With Tetraplegia","d":"For all individuals deprived of active and functional motor control of the upper limbs to perform grasping tasks, the restoration of a grasping function becomes a priority. The population concerned is mainly represented by so-called functional tetraplegic individuals. In this context, new technologies, and more particularly robotics, appear as a solution for substitution and compensation of motor impairment of the upper limb. Assistive robotic manipulation today relies on three robot concepts…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Mental Health","Motor Function","Quality of Life","Trunk Control"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07680361"},{"n":"NCT02163876","t":"Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury","d":"This study will evaluate the safety and efficacy of human central nervous system stem cell transplantation into patients with traumatic injury in the cervical region of the spinal cord.","s":"Terminated","tr":["Drugs","Stem Cells"],"o":["Arm Movement"],"st":["California","Florida","Illinois","Maryland","Michigan","Minnesota","New York","Pennsylvania","Texas","Utah","Wisconsin"],"co":["Canada","United States"],"lc":14,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02163876"},{"n":"NCT01321333","t":"Study of Human Central Nervous System Stem Cells (HuCNS-SC) in Patients With Thoracic Spinal Cord Injury","d":"This study will evaluate the effect of single transplantation of HuCNS-SC cells into the thoracic spinal cord of patients with sub-acute spinal cord injury.","s":"Completed","tr":[],"o":[],"st":[],"co":["Canada","Switzerland"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01321333"},{"n":"NCT05786313","t":"Study of Individualized, Precise and Standardized Cervical Open-door Surgery for Cervical Spinal Stenosis","d":"To evaluate the safety and effectiveness of individualized, precise and standardized open-door posterior cervical surgery through a single-center, exploratory clinical study, so as to provide a more reliable basis for the treatment of cervical spinal stenosis.","s":"Recruiting","tr":["Surgical Procedure"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05786313"},{"n":"NCT00879021","t":"Study of Pregabalin in the Prevention of Central Neuropathic Pain in Acute Spinal Cord Injury","d":"This research study will test to see if people who receive pregabalin after their spinal cord injury will develop less nerve damage pain than people who do not receive it.","s":"Terminated","tr":["Drugs"],"o":["Motor Function","Pain Management","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00879021"},{"n":"NCT03762655","t":"Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care","d":"This is a randomized, controlled, single-blind, multicenter, two Arm (Treatment or \"Scaffold\" Arm; Standard of Care or \"Comparator\" Arm) of a Neuro-Spinal Scaffold to evaluate whether the Scaffold is safe and demonstrates probable benefit for the treatment of complete T2-T12 spinal cord injury as compared to standard of care open spine surgery.","s":"Terminated","tr":["Devices","Surgical Procedure"],"o":["Bladder Function","Bowel Function","Sexual Function"],"st":["California","Colorado","Florida","Iowa","Maryland","New Jersey","New York","North Carolina","Pennsylvania","Rhode Island","Texas","Wisconsin"],"co":["United States"],"lc":16,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03762655"},{"n":"NCT00461474","t":"Study of Strengthening Exercises and Improving Movement for Painful Shoulders in Adults With Spinal Cord Injury","d":"The purpose of this study is to conduct research to see if we can help people who have a spinal cord injury and shoulder pain to decrease the pain in the shoulders. We are investigating the effectiveness of a home exercise program for the shoulders and changes in how tasks are performed compared to an educational program on shoulder pain. There are no new experimental procedures included in this study; instead it is a comparison of two types of treatment that have been provided for this problem…","s":"Completed","tr":[],"o":["Pain Management","Quality of Life"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00461474"},{"n":"NCT01569360","t":"Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury","d":"Corsets are often used in the management of patients with a spinal cord injury. They may help to rigidify the patients' trunk which might help some patients to sit upright; their use may also reduce the sensation of dyspnea some patients have while sitting upright. Due to spinal cord injury, abdominal muscles are weakened which can contribute to alter the respiratory function of the patients. But the corset by rigidifying the abdominal wall can improve the efficiency of the respiratory muscles…","s":"Withdrawn","tr":["Devices"],"o":["Blood Pressure","Breathing Function","Sensory Function","Spasticity","Trunk Control"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01569360"},{"n":"NCT00213356","t":"Study of the Nervous Control of the Anal Sphincter","d":"Anal incontinence and constipation are frequently observed in patients with neurological disease. The purpose of this study is to evaluate the neurological control of the anal sphincter in healthy subjects, patients with neurological disease by a new electrophysiological technique. This technique consists in recordings of anal sphincter responses after magnetic stimulations of the cortex and the sacral nerves.","s":"Withdrawn","tr":["Observational"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00213356"},{"n":"NCT04196114","t":"Study on Feasibility of Stimulation on the Lumbar Part of the Spinal Cord to Improve Mobility Recovery in Patients With Sub-acute Spinal Cord Injury","d":"The STIMO-2 study aims to investigate TESS-supported rehabilitation training in sub-acute spinal cord injury (\\< 6 months post-injury). The primary endpoint of this study is to assess the safety and feasibility of TESS. The preliminary effectiveness of the therapy is the secondary study endpoint. The mobility recovery status of patients, who undergo TESS-supported rehabilitation, will be assessed at 12 months post SCI, compared to their predicted recovery expectations based on standard…","s":"Withdrawn","tr":["Devices","Rehabilitation","Safety"],"o":["Motor Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04196114"},{"n":"NCT01217047","t":"Study on Functional Electrical Stimulation (FES) Cycling Following Spinal Cord Injury","d":"This research is being done to study the effect of Functional Electrical Stimulation (FES) cycling on factors in blood and spinal cord in people with spinal cord injury (SCI).","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Mental Health","Spasticity"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01217047"},{"n":"NCT06845904","t":"Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury","d":"This clinical trial aims to assess the preliminary safety and efficacy of Epidural Electrical Stimulation (EES) therapy in managing lower urinary tract dysfunction in individuals with sub-acute or chronic spinal cord injury (SCI). The study evaluates the therapy's potential to improve urinary function and prevent neurogenic detrusor overactivity, ultimately seeking to enhance quality of life for individuals with SCI.","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06845904","su":"https://scitrials.org/trial/NCT06845904"},{"n":"NCT05942339","t":"Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)","d":"The purpose of this pre-market clinical study is to assess the preliminary safety and efficacy of the ARC Therapy using the ARC-IM Lumbar System at supporting mobility in participants who have previously received a spinal array and an implantable pulse generator (IPG) either through the STIMO protocol (NCT02936453) or similar studies conducted abroad. They will be proposed to exchange their currently implanted system with components of the newly developed ARC-IM Lumbar system. The goal is to…","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Leg Movement","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05942339","su":"https://scitrials.org/trial/NCT05942339"},{"n":"NCT05878145","t":"Study on Rehabilitation Exercise Program for Community-based Spinal Cord Injury Patients","d":"In the case of spinal cord injury, patients have shown a passive attitude towards participating in leisure sports or exercise programs, and there is a lack of suitable guidelines or experience in the local community for coaching exercise and sports for spinal cord injury patients, which makes coaches feel burdened when coaching these patients. Therefore, in this study, a suitable comprehensive exercise program will be designed and prescribed for patients who reside in the local community and…","s":"Completed","tr":["Rehabilitation"],"o":["Hand Movement","Mental Health","Motor Function","Quality of Life","Trunk Control"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05878145"},{"n":"NCT04213742","t":"Study on the Application of Gratitude Intervention in Patients With Spinal Cord Injury","d":"To analyze the present situation and influencing factors of gratitude level and quality of life of patients with spinal cord injury, and to explore the methods of Thanksgiving intervention for patients with spinal cord injury so as to provide scientific basis for improving the quality of life of patients with spinal cord injury. Investigation and research design and experimental research design","s":"Unknown","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04213742"},{"n":"NCT05776862","t":"Study Testing Benefits of Ursolic Acid (UA) as a Countermeasure To Myopenia and Insulin Resistance in Chronic Spinal Cord Injury (SCI)","d":"This study will evaluate if Ursolic Acid supplementation may be effective in reducing muscle loss and improving blood sugar control in the SCI community.","s":"Completed","tr":["Drugs","Nutrition"],"o":["Motor Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05776862"},{"n":"NCT01833975","t":"Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Spinal Cord Injury","d":"This Study is a single arm,Phase I/II , single centre trial to check active comparing the safety and efficacy of Bone marrow derived autologous cell(100 million per dose) trial to be conducted for 36 months.","s":"Unknown","tr":["Stem Cells"],"o":["Motor Function","Pain Management","Sensory Function"],"st":[],"co":["India"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01833975"},{"n":"NCT01484184","t":"Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury","d":"As a first-in-class (Central Pattern Generator or CPG activator) approach, this tritherapy candidate called SPINALON has been identified and is currently under development for its capacity to temporarily induce episodes of involuntary locomotor movements. The primary objective of this Phase I/IIa study is to assess safety and tolerability of a single escalating dose of SPINALON (levodopa + carbidopa + buspirone) in chronic spinal cord-injured patients. As a secondary objective, preliminary…","s":"Completed","tr":["Drugs","Safety"],"o":["Blood Pressure","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01484184"},{"n":"NCT04683848","t":"Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury","d":"The purpose of this study is to compare the efficacy and safety of intravenous (IV) infusions of MT-3921 to placebo in subjects with acute traumatic cervical spinal cord injury. Subjects meeting eligibility criteria will enter the 6-month double-blind period. Subjects will be randomized in a 2:1 ratio to receive MT-3921 or placebo in a double blind manner.","s":"Completed","tr":["Drugs"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["California","Florida","Georgia","Kentucky","Michigan","Mississippi","Missouri","Nebraska","North Carolina","Ohio","Oregon","Texas","Virginia","Wisconsin"],"co":["Canada","Japan","United States"],"lc":23,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04683848"},{"n":"NCT02669849","t":"Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury","d":"The purpose of this study is to determine the efficacy and safety of VX-210 in subjects with Acute Traumatic Cervical Spinal Cord Injury. Secondary objectives include the specific evaluation of the effects of VX-210 on neurological recovery and daily function after spinal cord injury.","s":"Terminated","tr":["Drugs"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":["Alabama","Arizona","California","Florida","Georgia","Iowa","Kentucky","Maryland","Massachusetts","Michigan","Minnesota","Mississippi","Missouri","New Mexico","Ohio","Oklahoma","Pennsylvania","Rhode Island","Texas","Utah","Virginia","Washington"],"co":["Canada","United States"],"lc":39,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02669849"},{"n":"NCT00573976","t":"Study to Assess the Validity and Reliability of the Spinal Cord Independence Measure (SCIM III)","d":"In the past two decades there have been great strides made in understanding the biological changes resulting from spinal cord injury (SCI). The future holds promise of the development of therapies that will promote degrees of repair and recovery of function for people living with SCI. Lessons learned from past \"failed\" SCI clinical trials, however, demonstrate that, in order to accurately evaluate the overall effectiveness of SCI therapies, more sensitive outcomes measures are needed…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00573976"},{"n":"NCT00978341","t":"Study to Determine if a Reduction in Pain Can be Measured in Spinal Cord Injured Patients Using a New Study Design","d":"The study is designed to assess if spinal cord injury patients have reduced pain after taking either pregabalin or placebo in a cross over design. Patients had either pain at the level of their injury or below the level of their injury.","s":"Terminated","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["Australia"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00978341"},{"n":"NCT02259751","t":"Study to Determine Pharmacodynamic Effects and Pharmacokinetics of KUC 7483 CL in Patients With Spinal Cord Injury and Neurogenic Detrusor Overactivity","d":"Study to investigate pharmacodynamic effects and pharmacokinetics of KUC 7483","s":"Completed","tr":["Drugs"],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02259751"},{"n":"NCT01243125","t":"Study to Evaluate NVC-422 for Urinary Catheter Blockage and Encrustation","d":"NVC-422 is a topical, non-antibiotic, fast-acting, broad-spectrum anti-microbial, which exhibits the potential to prevent the growth of urinary pathogens, including Proteus and others. The use of a catheter irrigation solution that can prevent biofilm formation and encrustation leading to blockage may keep the catheter patent longer, resulting in fewer catheter changes, potentially lower incidence of UTIs, and better patient quality of life. The study population will include male and female…","s":"Completed","tr":["Devices","Drugs"],"o":["Bladder Function","Quality of Life"],"st":["California","Florida","New Jersey","North Carolina","Pennsylvania","South Carolina","Virginia","Washington"],"co":["United States"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01243125"},{"n":"NCT01855594","t":"Study to Evaluate the Efficacy of Lithium Carbonate in Spinal Cord Injury Patients With Neuropathic Pain","d":"To investigate the efficacy of lithium carbonate in the treatment of neuropathic pain of patients with spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Motor Function","Pain Management","Sensory Function","Spasticity"],"st":[],"co":["China"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01855594"},{"n":"NCT01502631","t":"Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI)","d":"The purpose of this research study is to gather scientific information about the effectiveness of the study drug, SUN13837 Injection, when compared with the placebo (inactive substance) in participants with acute spinal cord injury.","s":"Completed","tr":["Drugs","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Leg Movement","Motor Function","Quality of Life"],"st":["Arizona","California","Colorado","Delaware","Florida","Georgia","Hawaii","Indiana","Iowa","Kansas","Kentucky","Missouri","Nebraska","New Jersey","New York","North Carolina","Ohio","Pennsylvania","Wisconsin"],"co":["Canada","Czechia","France","Poland","Spain","United Kingdom","United States"],"lc":67,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01502631"},{"n":"NCT05524103","t":"Study to Evaluate the Safety and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury","d":"The purpose of this study is to assess the safety, tolerability and pharmacokinetics of ALMB-0166 in patients with acute spinal cord injury.","s":"Completed","tr":["Drugs","Safety"],"o":[],"st":[],"co":["China"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05524103"},{"n":"NCT07092293","t":"Studying Rehabilitation Treatments Using Video to Improve Recovery for Adults With Physical Disabilities","d":"This study aims to better understand how occupational therapists provide rehabilitation for adults recovering from stroke or spinal cord injury (SCI), with a focus on improving arm and hand function. Using video recordings of real outpatient therapy sessions, researchers will identify the key elements of treatment, such as the types of activities, the therapist's techniques, and how patients respond. The study will use the Rehabilitation Treatment Specification System (RTSS), a framework…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Hand Movement"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07092293","su":"https://scitrials.org/trial/NCT07092293"},{"n":"NCT00995215","t":"Sub-study to Spinal Cord Stimulation to Restore Cough","d":"Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough","s":"Completed","tr":["Electrical Stimulation"],"o":["Breathing Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00995215"},{"n":"NCT02165904","t":"Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI","d":"The study goes on 24 months, with recruiting, treatment and follow period for all patients. The first day for each patient will be the first cellular administration. 3 doses will be administrated every 3 months from first dose. When the clinical trial finishes, it will be done a completed check of all obtained parameters.","s":"Completed","tr":["Stem Cells"],"o":["Bladder Function","Quality of Life","Spasticity"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02165904"},{"n":"NCT02584426","t":"Subcutaneous Injection and Ultrasonic Dispersion of Cefazolin Into Chronic Pelvic-Region Pressure Ulcers in Persons With Spinal Cord Injury","d":"Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces. As many as 85% of individuals with a spinal cord injury (SCI) report the occurrence of at least 1 PU since being injured. Despite the increasing attention and emphasis on prevention, PUs still represent a major health risk for persons with SCI. PUs and other skin breakdowns are at risk for becoming infected; it is not uncommon for…","s":"Completed","tr":["Devices","Drugs"],"o":["Pressure Sores"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02584426"},{"n":"NCT00013338","t":"Supported Treadmill Ambulation Training After Spinal Cord Injury","d":"This is a randomized, controlled trial to compare supported treadmill ambulation training (STAT) to conventional gait training for improving gait speed, gait endurance, gait efficiency and muscle function in SCI subjects injured more than six months prior to start of training. Each subject will receive twelve weeks of either CGT or STAT, given as 20 minutes of training within a one-hour period per day, five days per week. These subjects will be studied baseline, 4,8 and 12 weeks of training…","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00013338"},{"n":"NCT03464409","t":"Supporting Patient Decisions About UE Surgery in Cervical SCI","d":"The goal of this study is to collect and describe patient and caregiver reported outcomes regarding surgical and non-surgical treatment for improving hand and arm function in the setting of cervical spinal cord injury. Eligible study participants will be recruited across the 4 sites and the investigators plan to recruit the following groups and numbers of participants: 1. Nerve or tendon transfer recipients: people who have elected to undergo nerve (N=10) or tendon (N=10) transfer surgery to…","s":"Completed","tr":["Surgical Procedure"],"o":["Quality of Life"],"st":["California","Missouri"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03464409"},{"n":"NCT03962582","t":"Supportive Wheelchair Back Compared to Fabric Back","d":"This study tests using a wheelchair back that supports the spine in a neutral position and one that allows the spine and pelvis to fall into a posterior pelvic tilt.","s":"Completed","tr":["Devices"],"o":["Breathing Function","Pain Management"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03962582"},{"n":"NCT05364099","t":"Suprascapular Nerve Block for Treatment of Shoulder Pain in Individuals With Spinal Cord Injuries","d":"The purpose of this study is to evaluate the effectiveness and safety of using suprascapular nerve block for individuals with chronic spinal cord injury who have chronic shoulder pain.","s":"Withdrawn","tr":["Drugs"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05364099"},{"n":"NCT01768910","t":"Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction","d":"The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established from findings in healthy subjects in the context of neurogenic and non-neurogenic LUT dysfunction.","s":"Completed","tr":[],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01768910"},{"n":"NCT00475748","t":"Surgical Management of Spinal Cord Injuries In Neck","d":"ABSTRACT/EXECUTIVE SUMMARY BACKGROUND, SIGNIFICANCE \\& RATIONALE: Between 10-20% of the more than 6000 cases of spinal cord injury seen annually in the North America have the clinical pattern of traumatic central cord syndrome (TCCS). These patients are usually older, most likely have sustained a fall, and have incomplete spinal cord injury characterized by dysesthetic and weak upper extremities. CT scan of the cervical spine in patients with TCCS often shows disc/osteophytes complex…","s":"Unknown","tr":["Surgical Procedure"],"o":["Motor Function","Sensory Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00475748","su":"https://scitrials.org/trial/NCT00475748"},{"n":"NCT01865942","t":"Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery","d":"The investigators wish to evaluate the effect of minimal access spinal surgery compared to traditional open surgery spinal surgery in patients with metastatic spinal cord compression. Minimal access surgery has been shown to bee less damaging for the tissue compared to traditional open surgery and also cause fewer wound complications, the investigators expect the above could have impact in a vulnerable patient group like patients with metastatic spinal cord compression.","s":"Completed","tr":["Surgical Procedure"],"o":["Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01865942"},{"n":"NCT01674764","t":"Surgical Treatment for Spinal Cord Injury","d":"Despite many years of research, an incomprehensible amount of scientific efforts worldwide and billions of dollars invested, no effective therapy resulting in major neurological or functional recovery is available to date for traumatic spinal cord injury (tSCI). Although there is increasing experimental evidence from animal models that surgical decompression of the spinal cord improves recovery after tSCI, clinical studies have not shown conclusive data yet. The main explanations for this lack…","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Motor Function","Quality of Life","Sensory Function"],"st":[],"co":["Austria","Bulgaria","Croatia","France","Germany","Ireland","Italy","Netherlands","Romania","Serbia","Turkey (Türkiye)","United Kingdom"],"lc":17,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01674764"},{"n":"NCT05967325","t":"SVF Combined With Functional Self-assembling Peptide Nanofiber Hydrogels in the Treatment of Spinal Cord Injury","d":"Traumatic spinal cord injury (SCI) is a severe medical problem experienced by people worldwide with high mortality and long term morbidity. Although progress has been made in understanding cellular and molecular mechanisms of SCI, treatment and management protocols aimed at ameliorating neurologic damage in patients remain ineffective. Cells and biomaterials offer new hope for the treatment of SCI. Up to now, there have been many studies on the treatment of SCI using cells and biomaterials…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05967325","su":"https://scitrials.org/trial/NCT05967325"},{"n":"NCT05041114","t":"SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis","d":"The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex. The purpose of this research is to evaluate safety and feasibility. The MNP is a type of implantable brain computer interface which bypasses dysfunctional motor neurons. The device is designed to restore the transmission of neural signal from the cerebral cortex utilized for neuromuscular control of…","s":"Withdrawn","tr":["Brain Machine Interface (BMI)","Devices","Safety"],"o":["Arm Movement"],"st":[],"co":["Australia"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05041114"},{"n":"NCT02115685","t":"Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury","d":"Significance: The long term objective of this study is to improve physical therapy and fitness programs in people with spinal cord injury. The results of the study will demonstrate the importance of matching blood flow to a muscle with exercise of that same muscle. Scientific Objective: The objective of the study is to measure how the body regulates bloodflow to a muscle during exercise. We intend to study these effects by triggering blood flow changes during movement, and measuring bloodflow…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02115685"},{"n":"NCT02180880","t":"Symptom Based Treatment of Neuropathic Pain","d":"1\\. Neuropathic pain in spinal cord injured patients 1. Inclusion criteria * pain intensity, visual analogue scale \\> 3 * a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above * aged ≥20 2. Method * Stop pain medications * Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily) * Check pain intensity (VAS score) with Baron's classification","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02180880"},{"n":"NCT07115693","t":"Synchronous Tele-Resistance Training to Improve Upper Extremity Function in Patients With Spinal Cord Injury","d":"This study investigated the effects of resistive exercises applied with synchronized telerehabilitation on upper extremity functions in patients with SCI who use wheelchairs. A randomized controlled trial included 21 patients with SCI between the ages of between18 and 60. Participants were divided into two groups: the Study Group (n=11) and the Control Group (n=10). Participants in the study group applied resistive exercise with a synchronized telerehabilitation method, while participants in…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Motor Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07115693"},{"n":"NCT07334977","t":"Synergistic Effect of Non-invasive Brain and Spinal Cord Stimulation","d":"The goal of this clinical study is to investigate the potential synergy between non-invasive brain and spinal cord stimulation administered during a cognitive-motor task, in terms of their immediate effects on sensorimotor and cognitive functions after neurological injuries affecting the upper limb (cervical spinal cord injury and stroke). Secondary objectives are to evaluate the relevance of anatomical MRI, functional MRI, and neurophysiological measurements for optimizing and predicting the…","s":"Recruiting","tr":["Transcranial Direct Current Stimulation (tDCS)","Transcutaneous Stimulation"],"o":[],"st":[],"co":["France"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT07334977","su":"https://scitrials.org/trial/NCT07334977"},{"n":"NCT02991690","t":"Systemic Hypothermia in Acute Cervical Spinal Cord Injury","d":"This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).","s":"Recruiting","tr":["Safety"],"o":[],"st":["Arizona","Florida","Georgia","Indiana","Maryland","Pennsylvania","South Carolina"],"co":["United States"],"lc":7,"rlc":5,"cu":"https://clinicaltrials.gov/study/NCT02991690","su":"https://scitrials.org/trial/NCT02991690"},{"n":"NCT05589415","t":"Targeted HD-tDCS to Improve Upper Limb Rehabilitation in SCI","d":"The proposed project seeks to maximize the functional recovery achieved during the rehabilitation of the paretic upper limbs in individuals with SCI. The investigation will work towards optimizing the use of transcranial direct current stimulation (tDCS), an adjunct known to improve the effectiveness of rehabilitation. In particular, the relationship between the specificity of current delivery and functional benefit will be explored, and findings may lead to a framework that can be translated…","s":"Active, not recruiting","tr":["Brain Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05589415","su":"https://scitrials.org/trial/NCT05589415"},{"n":"NCT04288245","t":"Targeted Plasticity Therapy for Upper Limb Rehabilitation in Spinal Cord Injuries","d":"Texas Biomedical Device Center at UT Dallas has developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury termed targeted plasticity therapy (TPT). This technique uses brief pulses of vagus nerve stimulation to engage pro-plasticity neuromodulatory circuits during rehabilitation exercises. Recovery is associated with neural plasticity in spared motor networks in the brain and spinal cord. Moreover, an early feasibility study and an independent…","s":"Active, not recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04288245","su":"https://scitrials.org/trial/NCT04288245"},{"n":"NCT06701422","t":"Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery","d":"The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).","s":"Recruiting","tr":["Epidural Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["New York"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06701422","su":"https://scitrials.org/trial/NCT06701422"},{"n":"NCT03179475","t":"Targin® for Chronic Pain Management in Patients With Spinal Cord Injury","d":"The study will be investigating the effectiveness of oxycodone-naloxone (brand name Targin®) at treating chronic pain in individuals with spinal cord injury. The goal of the study is to compare the effectiveness of Targin® at treating chronic pain in individuals with sub-acute and chronic spinal cord injury compared to opioid medication that is not compounded with naloxone.","s":"Completed","tr":["Drugs"],"o":["Bowel Function","Pain Management","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03179475"},{"n":"NCT06494020","t":"Task Practice and Spinal Cord Stimulation","d":"The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity. Transcutaneous stimulation has been shown to improve motor function in some individuals with chronic spinal cord injury. The study intends to explore scientifically the association between higher stimulation frequencies and spasticity/hypertonicity.","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Hand Movement"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06494020","su":"https://scitrials.org/trial/NCT06494020"},{"n":"NCT05452707","t":"Task-oriented Arm/Hand Skill Rehabilitation and Therapy Dose Dimensions in Subacute Spinal Cord Injury Rehabilitation","d":"The study is a multicenter longitudinal observational study. The therapy content and the therapy dosage of arm/skill training for patients with cervical spinal cord injury (SCI) will be observed for the primary objective. The aim is to get insight into the current therapy content and the current therapy dosage in arm/hand skill training, with the overall aim to optimize the arm/hand skill training. For the secondary objective, in addition to the patients with cervical SCI also, patients with…","s":"Unknown","tr":["Rehabilitation"],"o":["Hand Movement"],"st":[],"co":["Belgium","Netherlands"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT05452707","su":"https://scitrials.org/trial/NCT05452707"},{"n":"NCT03364660","t":"Task-specific Epidural Stimulation Study","d":"The investigators propose to understand the role of lumbosacral spinal cord epidural stimulation (scES) in recovery of autonomic nervous system function, voluntary movement, and standing in individuals with severe spinal cord injury (SCI). Thirty-six individuals with severe SCI who have cardiovascular and respiratory dysfunction and who are unable to voluntarily move the legs or stand will receive scES for cardiovascular function, voluntary movement, or standing with and/or without…","s":"Unknown","tr":["Epidural Stimulation"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03364660","su":"https://scitrials.org/trial/NCT03364660"},{"n":"NCT03144388","t":"Task-specificity for Locomotor Recovery Following SCI","d":"The primary goal of the proposed study is to identify the contributions of the amount of task-specific practice on locomotor (i.e., walking) recovery in patients with chronic (\\> 1 yr) motor incomplete spinal cord injury (iSCI). Consistent with principles of motor learning and exercise physiology, the investigators contend that certain training (i.e., dosage) parameters of physical rehabilitation are critical to mobility outcomes following neurological injury. Specifically, the specificity…","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Indiana"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03144388"},{"n":"NCT07524491","t":"taVNS During Exercise and Recovery in Chronic Spinal Cord Injury","d":"This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI). Participants undergo two experimental conditions (active taVNS and sham stimulation) in a randomized crossover design while performing a standardized exercise protocol. Heart rate variability (HRV) is used as a non-invasive biomarker to assess autonomic nervous system dynamics…","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07524491"},{"n":"NCT05801536","t":"TCES for Upper Limb Function in Cervical SCI","d":"Following a cervical spinal cord injury (cSCI; damage to the spinal cord at the neck) there is catastrophic loss of hand and grip function. This has a devastating effect on quality of life and functional independence. Thus, there is a real need to identify and optimise therapy to aid functional arm and hand recovery. One such therapy is Transcutaneous Electrical Stimulation (tCES). This involves applying sticky pads to the skin and then transmitting a low-level electrical current to the spinal…","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05801536"},{"n":"NCT03052244","t":"tDCS and VI to Treat Neuropathic Pain and Function in SCI","d":"Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) will be applied for patient who suffer from neuropathic pain following spinal cord injury The tDCS treatment will be coupled with a video of a man walking (creating a visual illusion) in order to enhance functional ability and reduce pain","s":"Unknown","tr":["Brain Stimulation"],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03052244","su":"https://scitrials.org/trial/NCT03052244"},{"n":"NCT03621969","t":"Technology Development for Physical Rehabilitation of Patients With Upper Extremity Motor Deficits (RePlay)","d":"Injuries and disease processes that produce upper extremity deficits are devastating to patients and their families. One potential avenue to treat these neurological disorders is through the enhancement of neural plasticity, which is the ability of the brain to reorganize and recover following insult. After a minor injury, the brain undergoes beneficial neural plasticity, compensating for altered neural activity to restore normal function. However, in the cases of moderate to severe injury and…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Plasticity"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03621969"},{"n":"NCT04760470","t":"Technology-assisted Upper Extremity Rehabilitation in Subjects with Incomplete Cervical Spinal Cord Injury","d":"The aim of the study is to investigate the effects of 6 weeks of technological-assisted rehabilitation on function of upper extremity and hand in subjects with incomplete cervical spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Finland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04760470"},{"n":"NCT07022808","t":"Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury","d":"To achieve our specific aims and hypotheses we will conduct a parallel group mixed methods randomized control trial comparing participation in the TEEMS program with exercise via asynchronous video library equivalent (control). The use of mixed methods will allow for the integration of quantitative findings with the qualitative, lived perspective of participants to provide a comprehensive analysis of the tele-exercise program outcomes. All aspects of the study from recruitment, screening, data…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07022808","su":"https://scitrials.org/trial/NCT07022808"},{"n":"NCT06079138","t":"Tele-rehabilitation Using TDCS Combined with Exercise in People with Spinal Cord Injury","d":"This study aims to explore the effect of trans cranial direct current stimulation (tDCS) combined with self-exercise at home for 1 month training (3 sessions/week, for 4 weeks). The outcome assessment including motor function, functional activity, spasticity through neurological assessment (H reflex latency and H/M amplitude ratio) and quality of life will be assessed before, after the intervention and at 1- month follow-up. Participant will communicate with physical therapist via video online…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Direct Current Stimulation (tDCS)"],"o":["Arm Movement","Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Thailand"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06079138"},{"n":"NCT04248725","t":"Telehealth Pain Self-Management for Employed Adults","d":"The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed. Participants from anywhere in the US will be randomized to either E-TIPS, a cognitive-behavioral pain self-management intervention delivered by telephone, or a waitlist control. Outcomes, including pain interference, will be assessed at baseline, mid-treatment, post-treatment, and 6-month…","s":"Completed","tr":[],"o":["Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04248725"},{"n":"NCT05318079","t":"Telehealth Virtual Reality Exergaming for Spinal Cord Injury","d":"This pilot feasibility study aims to test whether youth and adults with spinal cord injury can use a group virtual reality gaming intervention to exercise. A second purpose is to examine whether there are potential benefits to cardiometabolic health and psychosocial health.","s":"Withdrawn","tr":[],"o":["Blood Pressure","Hand Movement","Mental Health","Motor Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05318079"},{"n":"NCT02800915","t":"Telemedicine Makes the Patient Stay in Hospital at Home","d":"The goal of the project is to study whether multidisciplinary follow- up performed via telemedicine to the patient in his or her own home, will improve the healthcare services offered to a particular group of patients. The hypotheses are that this could increase the treatment options, increase knowledge translation, give significant socioeconomic benefits, and allow greater accessibility to specialized healthcare services, as well as increase the involvement of patients and those working in…","s":"Completed","tr":[],"o":["Pressure Sores","Quality of Life"],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02800915"},{"n":"NCT05597176","t":"Telemonitored Exercise to Attenuate Metabolic Dysregulation in Spinal Cord Injury","d":"The purpose of this research is to test the health benefits of using functional electrical stimulation for lower extremity exercise at home.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Leg Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05597176"},{"n":"NCT05468437","t":"Telenutrition for Individuals With SCI","d":"This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury. Nutrition counseling may help participants to develop eating behaviors that match the participants' needs and help improve heart health. The purpose of this project is to decrease the risk of complications like obesity, high cholesterol, or diabetes, and explore associations between bowel and bladder function…","s":"Active, not recruiting","tr":["Nutrition"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05468437","su":"https://scitrials.org/trial/NCT05468437"},{"n":"NCT03714217","t":"Telenutrition in Spinal Cord Injury","d":"The purpose of the study is to provide tele-nutrition counseling after a spinal cord injury (SCI). During the three months of participation, subjects will be given an iPad and the iPad will be used to record meals using a photo journal application, YouAte. In addition, subjects will receive dietary advice two times a month with a registered dietitian (RD). The dietitian role in the study will be to educate healthy weight management and accommodate any cultural and behavioral habits. The…","s":"Completed","tr":["Nutrition"],"o":["Quality of Life"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03714217"},{"n":"NCT00663663","t":"Telephone Intervention for Pain Study (TIPS)","d":"Treatments teaching people how to manage pain have been used to treat chronic pain in the general population. The purpose of this study is to see if these treatments delivered over the telephone can benefit persons with multiple sclerosis, spinal cord injury or an acquired amputation. Specifically, we want to determine if these treatments can help reduce the negative consequences that pain often causes in terms of a person's mood, daily activities, and enjoyment of life. We are also interested…","s":"Completed","tr":[],"o":["Mental Health","Pain Management"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00663663"},{"n":"NCT03711760","t":"Telepsychology in Spinal Cord Injury","d":"This study will determine the effectiveness of tele-psychology in treating persons with spinal cord injury (SCI) with depressed mood in the early period post-rehabilitation discharge. Depression among individuals with SCI is the most common psychological condition following an injury; 22% of civilians with SCI and 28% of veterans with SCI experience depression after injury, which is higher than the able-bodied population (Williams 2015; Ullrich 2014). Individuals with SCI face many barriers in…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03711760"},{"n":"NCT06069999","t":"Telerehabilitation Early After CNS Injury","d":"The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets to improve arm function by introducing telerehabilitation to the bedside of participants during the inpatient rehab admission period. Participants will use a newly developed functional training system (HandyMotion) to access therapy treatment program…","s":"Active, not recruiting","tr":["Rehabilitation"],"o":["Arm Movement"],"st":["California","Florida","Pennsylvania","Utah"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06069999","su":"https://scitrials.org/trial/NCT06069999"},{"n":"NCT04914650","t":"TEleRehabilitation Nepal (TERN) to Improve Quality of Life of People With Spinal Cord Injury and Acquired Brain Injury","d":"Nepal is a low-income country with over 3 million individuals with physical disabilities and currently no government-run specialist rehabilitation services. The aim of this research proposal is to work in partnership with a Nepal Non-Governmental Organisation (NGO), the Spinal Injury Rehabilitation Centre (SIRC, Nepal) to achieve the following: 1. estimate the rehabilitation needs in individuals after stroke, brain injury and spinal cord injury in rural communities after discharge from SIRC 2…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Nepal"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04914650"},{"n":"NCT05589402","t":"Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI","d":"The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury (SCI). In this study, the aim is to determine if temporarily numbing non-paralyzed arm muscles with an over-the-counter numbing cream while exercising paralyzed muscles, can improve the strength, function, and sensation of paralyzed muscles after a spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05589402","su":"https://scitrials.org/trial/NCT05589402"},{"n":"NCT05356442","t":"Tenodesis Grip Strength With Functional Hand Recovery in Cervical Spinal Cord Injury","d":"Spinal cord injury (SCI) is devastating event, the individual become significant burden on their family and society SCI is impairments of sensory, motor and autonomic functions. There is no proper cure and care after SCI, no proper assessment and treatment is present in under developed countries Cross sectional study design will be used and 75 patients included in this study. The population included age 21-55 years, both gender included, teraplegic with lesion level C5-C7, Mini Mental State of…","s":"Completed","tr":["Observational"],"o":["Hand Movement","Motor Function","Quality of Life"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05356442"},{"n":"NCT03267810","t":"TENS Trial to Prevent Neuropathic Pain in SCI","d":"The purpose of this research study is to: 1) test whether transcutaneous electrical nerve stimulation (TENS) after spinal cord injury can reduce the onset of post-injury neuropathic pain; and 2) to learn more about this kind of pain and who is at risk for suffering from this type of pain after spinal cord injury. Neuropathic pain is a type of pain that occurs in about 50% of people with spinal cord injury. This type of pain is usually described as \"burning\" or \"tingling,\" and is present around…","s":"Terminated","tr":["Drugs","Transcutaneous Stimulation"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03267810"},{"n":"NCT07208188","t":"tESCS for Upper Limb Rehab in Spinal Cord Injury","d":"Regaining hand and arm function is an important step towards regaining independence following high-level spinal cord injury (tetraplegia). The delivery of small electrical pulses over the skin above the spinal cord, called transcutaneous spinal cord stimulation (tESCS), appears to improve the arm and hand function of people who have had tetraplegia for several years when delivered at the same time as upper limb therapy. However, tESCS has not been tested in people who have a new spinal cord…","s":"Not yet recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07208188","su":"https://scitrials.org/trial/NCT07208188"},{"n":"NCT01142115","t":"Test of Discomfort and Malaise of Two Different Urine Catheters in Healthy Volunteers","d":"The purpose of this study is to evaluate the safety of a new developed catheter in comparison with an catheter on the market. The study is randomised.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01142115"},{"n":"NCT05527691","t":"Testing SupportGroove: a Novel Mhealth Intervention for Couples Coping with Spinal Cord Injury","d":"The purpose of this study is to test the preliminary effects of an 8-week mobile application-based program (SupportGroove) developed for persons with spinal cord injury and their romantic partners.","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":["Utah","Virginia"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05527691"},{"n":"NCT04995796","t":"Testing the Decision Aid: Supporting Patient Decisions About Upper Extremity Surgery in Cervical SCI","d":"Purpose: The objective of this study is to assess a newly created decision support intervention (DSI) or decision aid (DA) for people with spinal cord injury (SCI) to learn about and consider upper extremity reconstructive surgery to help them choose a course of treatment that most aligns with their values.","s":"Completed","tr":["Surgical Procedure"],"o":["Arm Movement"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04995796"},{"n":"NCT03345576","t":"Testosterone and Long Pulse Stimulation After SCI","d":"Denervation following spinal cord injury (SCI) limits beneficial application of neuromuscular electrical stimulation (NMES). SCI with denervation results in extensive muscle atrophy that is accompanied with several cardio-metabolic health risks. The current proposal provides a novel intervention by examining the effects of long pulse width stimulation (LPWS) and testosterone replacement therapy (TRT) on restoring muscle size and leg lean mass after denervation in persons with SCI. This…","s":"Completed","tr":["Drugs","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":["Leg Movement"],"st":["Virginia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03345576"},{"n":"NCT06130449","t":"Testosterone and Neural Function","d":"Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS). Testosterone (T) plays a significant role in brain health and ANS reflex function in non-neurologically impaired men. However, little is known about the relationships between T, nerve function, and ANS dysfunction after SCI. Interestingly, up to 60% of men with SCI exhibit persistently low T…","s":"Recruiting","tr":[],"o":["Sexual Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06130449","su":"https://scitrials.org/trial/NCT06130449"},{"n":"NCT07227740","t":"Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury","d":"Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life. The factors that lead to the heighten and accelerated risk of heart attacks and strokes in adults living with SCI remain poorly understood. The investigators aim to uncover why this happens and find ways to prevent it. Our research focuses on how important cells which line blood vessels, called endothelial cells, function after…","s":"Recruiting","tr":[],"o":["Quality of Life"],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07227740","su":"https://scitrials.org/trial/NCT07227740"},{"n":"NCT02248701","t":"Testosterone Plus Finasteride Treatment After Spinal Cord Injury","d":"The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced ambulatory dysfunction subsequent to incomplete spinal cord injury. The investigators hypothesize that this treatment will improve bone mineral density, enhance muscle size and muscle function, and improve body composition, without causing prostate enlargement.","s":"Terminated","tr":["Drugs"],"o":["Bone Strength","Walking Function"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02248701"},{"n":"NCT00266864","t":"Testosterone Replacement Therapy in Chronic Spinal Cord Injury","d":"It has long been recognized that co-morbidity associated with multiple metabolic syndrome, such as adverse body composition, insulin resistance and autonomic nervous system impairment, may lead to significant increase in cardiovascular morbidity and mortality. It is unclear whether the co-morbidity evident in this population are due directly to their immobility or are the result of unfavorable changes in their underlying hormonal milieu. The purpose of this study is to determine the effect of…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Mental Health","Motor Function"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00266864"},{"n":"NCT07742553","t":"Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial","d":"Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life. These deficits result from reduced activity after SCI and may be worsened by low testosterone, which is present in many men with SCI. In older men with low testosterone who do not have SCI, testosterone therapy (TRT) is known to increase muscle mass, muscle strength, and bone mineral density…","s":"Not yet recruiting","tr":["Drugs"],"o":["Bone Strength","Leg Movement","Motor Function","Quality of Life","Walking Function"],"st":["Colorado","Florida","New York"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07742553"},{"n":"NCT06197113","t":"Teta Burst Versus 10 Hz Repetitive Transcranial Magnetic Stimulation İn Neuropathic Pain: A Sham Controlled Comparison","d":"Neuropathic pain is a common complication after spinal cord injury (SCI), which significantly affects the patient's quality of life and may be resistant to pharmacological treatment. In our study, we aimed to evaluate the efficacies of intermittent theta burst (iTBS) and high frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) by comparing them with each other and with sham stimulation, in the treatment of neuropathic pain resistant to pharmacological treatment in patients…","s":"Completed","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06197113"},{"n":"NCT04964635","t":"TETRAGRIP II - Usability Trial of an FES Orthosis for People With Tetraplegia.","d":"Functional Electrical Stimulation is an established technique in which small electrical impulses are used to cause a contraction in muscles and thereby enable movement, in people with neurological or musculoskeletal problems who are unable to undertake those movements themselves. People with spinal cord injuries of the neck at C5, C6 and C7 account for 35% of all spinal cord injuries. Despite this, there is only one commercial FES (Functional Electrical Stimulation) based orthosis currently…","s":"Completed","tr":["Devices","Electrical Stimulation","Exoskeleton","Functional Electrical Stimulation (FES)"],"o":["Hand Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04964635"},{"n":"NCT05207046","t":"The ACCESSIT Study","d":"The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.","s":"Recruiting","tr":["Observational"],"o":["Breathing Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05207046"},{"n":"NCT06908850","t":"The Aim of This Research is to Better Understand How Complete Spinal Cord Injury May Change Erogenous Zones in Adult Males","d":"A complete spinal cord injury (SCI) in men is characterized by the total loss of motor skills and sensations below the injury. The loss of penile sensation, the erogenous zone primarily involved in sexual response, is involved in sexual dysfunction, impacting sexual pleasure and quality of life. The management of genito-sexual dysfunction is a priority for paraplegic patients, ahead of bladder-sphincter and motor functions. For tetraplegic patients, the restoration of genito-sexual functions is…","s":"Enrolling by invitation","tr":[],"o":["Sexual Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06908850","su":"https://scitrials.org/trial/NCT06908850"},{"n":"NCT00854555","t":"The ATLET Study: Can Subjects With Incomplete Spinal Cord Injury Learn to Walk?","d":"The ATLET study will assess the effect of manual or robotic body-weight supported locomotor training of patients with stable motor incomplete spinal cord injury (SCI) on gait and overall ADL function as well as on estimated health care costs.","s":"Completed","tr":["Rehabilitation"],"o":["Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Norway"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00854555"},{"n":"NCT03109782","t":"The Austrian Spinal Cord Injury Study","d":"Traumatic spinal cord injury (tSCI) is a debilitating disease that leads to neurological deficits and often has long-term effects including severe lifelong disability. Given the devastating personal and economic consequences of SCI, it is critical to collect high-quality, prospective data. SCI has not been systemically assessed in Austria, and data regarding the etiology, incidence and prevalence are missing or significantly limited. More importantly to the individuals suffering from SCI…","s":"Unknown","tr":["Observational","Rehabilitation"],"o":["Motor Function","Quality of Life","Sensory Function","Walking Function"],"st":[],"co":["Austria"],"lc":18,"rlc":18,"cu":"https://clinicaltrials.gov/study/NCT03109782","su":"https://scitrials.org/trial/NCT03109782"},{"n":"NCT03046875","t":"The Biophysical Impact of Transcutaneous Spinal Cord Stimulation Within a Single Session","d":"To determine the biophysical impact of biophysical Impact of Transcutaneous Spinal Cord Stimulation (TSCS) within a single session. We hypothesize that subjects will demonstrate increased volitional muscle strength with TSCS. This will be assessed by isokinetic strength testing of post-injury dominant-side knee extension. Subjects will be tested in both Transcutaneous Spinal Cord Stimulation and sham conditions.","s":"Withdrawn","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Leg Movement","Motor Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03046875"},{"n":"NCT01279811","t":"The Canadian Multicentre CSF Monitoring and Biomarker Study","d":"The purpose of this study is to: 1. Measure the pressure in the spinal fluid surrounding the spinal cord to find out how well the spinal cord is being supplied with blood. 2. Determine how drugs called \"vasopressors\", which are used to control blood pressure following SCI (spinal cord injury), influence spinal fluid pressure. 3. Characterize the severity of an SCI using the levels of specific proteins found within the spinal fluid. 4. Predict how much neurologic recovery may be regained using…","s":"Completed","tr":[],"o":["Blood Pressure","Pain Management"],"st":["California"],"co":["Canada","United States"],"lc":6,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01279811"},{"n":"NCT06537427","t":"The Crosstalk Between the Epigenome and Mitochondria in SCI","d":"SCI is a devastating neurological disorder for which there are not yet restorative therapies. Thus, there is a need to explore new therapeutic strategies to treat SCI patients. To this end an appropriate selection and enrolment of suitable participants is crucial for the success of the therapeutic protocol. The selection of participants in SCI trials is often based on injury categories (e.g. sensorimotor complete vs incomplete), and neglects biological aspects (e.g. biomarkers released into the…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06537427","su":"https://scitrials.org/trial/NCT06537427"},{"n":"NCT06296771","t":"The Effect of a Combined Aerobic and Resistance Exercise (CARE) Training Programme on Cardiometabolic Outcomes in Individuals With Chronic Spinal Cord Injury: A Randomised Controlled Trial","d":"The goal of this study is to investigate the effectiveness of an 8-week dietary energy restriction with exercise or dietary energy restriction alone on the cardiometabolic health outcomes of individuals with chronic spinal cord injury. This study is a randomised controlled trial conducted at a single centre, consisting of two parallel arms. The main questions it aims to answer are: 1. the effectiveness of an 8-week dietary energy restriction with exercise or dietary energy restriction alone on…","s":"Unknown","tr":["Nutrition"],"o":[],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06296771","su":"https://scitrials.org/trial/NCT06296771"},{"n":"NCT06363357","t":"The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements of the Upper Limb in Patients With Neuromuscular Disorder","d":"The goal of this clinical trial is to investigate the effect of a muscle-mimicking, fabric-type shoulder orthosis on functional movements of the upper limb in patients with neuromuscular disorder. The main questions it aims to answer are: * What is the impact of the muscle-mimicking, fabric-type shoulder orthosis on upper limb functional movements in patients with neuromuscular disorder? * Are there observable differences in upper limb function when the shoulder orthosis is worn versus when it…","s":"Completed","tr":["Devices"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06363357","su":"https://scitrials.org/trial/NCT06363357"},{"n":"NCT05542238","t":"The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury","d":"The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls in the following conditions: supine rest and head-up tilt/face-cooling test; 2) examine if autonomic completeness/ incompleteness, physical activity, and psychological distress are predictors for dysfunctions during supine rest and head-up tilt/face cooling conditions in…","s":"Terminated","tr":["Rehabilitation"],"o":["Blood Pressure","Mental Health"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05542238"},{"n":"NCT05341466","t":"The Effect of Acute Intermittent Hypoxia on Motor Learning","d":"The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.","s":"Completed","tr":["Intermittent Hypoxia"],"o":["Plasticity"],"st":["Colorado"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05341466"},{"n":"NCT00535210","t":"The Effect of an Exercise Program on Physical Function After a Spinal Cord Injury","d":"This study would focus on adding a group exercise program to the usual therapy delivered in the hospital. We propose to design an exercise program that would be 30 minutes in length, 3 times per week. A medical doctor and physiotherapist would oversee the design and monitoring of the program. We believe that this program will: 1) Increase the potential for better health, thus improving independence and quality of life; 2) Help people make the move from therapist run exercise to self management…","s":"Terminated","tr":[],"o":["Blood Pressure","Quality of Life","Trunk Control"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00535210"},{"n":"NCT01988142","t":"The Effect of Continuous Passive Motion Training on Neuromuscular Adaptation","d":"After spinal cord injury (SCI), the muscular property altered due to the immobilization adaptation. The purpose of this study was to investigate the effect of remobilization with continuous passive exercise on the adapted paralyzed muscle properties after SCI.","s":"Completed","tr":[],"o":["Spasticity"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01988142"},{"n":"NCT02099890","t":"The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury","d":"Spinal cord Injury (SCI) is a condition commonly associated with a state of chronic low-grade inflammation due to a variety of factors such heightened risk for infection and development of metabolic disorders. Many disorders which have been demonstrated to have an inflammatory basis have also been found to be at much higher prevalence following SCI. Such conditions include, but are not limited to, depression, cognitive impairment, neuropathic pain, and somatic/autonomic nerve function. The fact…","s":"Completed","tr":["Nutrition"],"o":["Mental Health","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02099890"},{"n":"NCT07325149","t":"The Effect of Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation on Bone Strength.","d":"Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical complications that can devastate quality of life. There is a scarcity of research that has successfully implemented rehabilitation and/or exercise training interventions to preserve the musculoskeletal system during the acute phase SCI, or possibly reverse the muscle and bone…","s":"Not yet recruiting","tr":["Exoskeleton","Transcutaneous Stimulation"],"o":["Bone Strength"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07325149","su":"https://scitrials.org/trial/NCT07325149"},{"n":"NCT03517787","t":"The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life","d":"Aim of the current study is to evaluate the effect functional electrical stimulation and therapeutic exercise on traumatic spinal cord injured participants'skeletal muscle characteristics, sitting balance, lung function and quality of life.","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Breathing Function","Quality of Life","Spasticity","Trunk Control"],"st":[],"co":["Estonia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03517787"},{"n":"NCT00291317","t":"The Effect of FES on Children With Spinal Cord Injury","d":"Regular exercise is strongly recommended to help maintain a healthy lifestyle. Unfortunately, children and young adults with damaged spinal cords may not be able to exercise regularly. However, there is an exercise bike specially designed for persons with damaged spinal cords that enables them to pedal by directly stimulating the muscles in their legs. Our study is designed to determine the benefits of exercise for Spinal Cord Injured (SCI) patients using this bike.","s":"Completed","tr":["Functional Electrical Stimulation (FES)"],"o":["Bone Strength","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00291317"},{"n":"NCT06541197","t":"The Effect of Functional Electrical Stimulation Cycling Ergometry in Addition to Robotic Rehabilitation","d":"Spinal cord injury (SCI) is a devastating neurological condition resulting from either traumatic or non-traumatic causes, leading to loss of motor, sensory, and autonomic functions in individuals. Statistics indicate that more than 75% of individuals with incomplete SCI regain some degree of ambulatory function. Authors' aim in this study is to investigate the effect of adding functional electrical stimulation (FES) bicycle ergometry to robotic rehabilitation on lower extremity functional…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06541197"},{"n":"NCT03255330","t":"The Effect of Gabapentin Used as a Preemptive to the Emergence and Development Chronic Neuropathic Pain in Patients After Spinal Cord Trauma","d":"Study of the effect of gabapentin used as a preemptive to the emergence and development chronic neuropathic pain in patients after spinal cord trauma","s":"Withdrawn","tr":["Drugs"],"o":["Pain Management","Quality of Life"],"st":[],"co":["Czechia"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03255330"},{"n":"NCT00931983","t":"The Effect of Locomotor Training on Children With Incomplete Spinal Cord Injuries","d":"--Participation open to all Canadian residents-- The purpose of this study is to address how well children with incomplete spinal cord injuries of greater than 12 months duration who remain non-functional ambulators improve through body weight assisted treadmill training (BWATT).","s":"Withdrawn","tr":["Observational","Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00931983"},{"n":"NCT04500223","t":"The Effect of Neck Stabilization Exercise Plus Cardiopulmonary Rehabilitation on Pulmonary Function of SCI","d":"Cervicocranial flexion exercise (CCFE) and superficial neck flexor endurance training have been widely implemented in clinical practice for curing chronic neck pain. By means of CCFE, the muscle balance between deep neck flexor and superficial flexor would be optimal during neck movement. In other words, the superficial neck flexor( scalenes, SCM, and trapezius) would not overactive and the fatigue threshold might increase. Superficial neck flexor endurance training is proved to be efficient in…","s":"Completed","tr":["Rehabilitation"],"o":["Breathing Function","Motor Function","Pain Management","Trunk Control"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04500223"},{"n":"NCT04914975","t":"The Effect of NMES on Bowel Management in People With Chronic SCI","d":"It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela. As an alternative to abdominal massage or the use of suppositories, the electrical stimulation (ES) of the abdominal wall has been shown to be effective in decreasing the bowel transit time as well as decreasing constipation in children with slow-transit constipation. Due to the intrinsic nature of the guts' innervation…","s":"Completed","tr":["Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04914975"},{"n":"NCT02299557","t":"The Effect of Oxymetazoline Gel on Anal Pressure and Incontinence in Spinal Cord Injury Patients","d":"This is an double blinded, cross-over study to determine the effect of Oxymetazoline gel on anal resting pressure and fecal incontinence in patients with spinal cord injury. Approximately 17 subjects are expected to complete this 10 weeks study that will include two treatment periods of 4 weeks each, and one 2 weeks wash out period.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["Hungary"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02299557"},{"n":"NCT06870331","t":"The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury","d":"The goal of this clinical trial is to evaluate the effect of probiotic and prebiotic supplementation in individuals with chronic spinal cord injury experiencing gastrointestinal complaints. The main questions this trail aims to answer are: * what are the effects of the supplementation on gastrointestinal symptoms? * what are the effects of the supplementation on gut microbiome composition? * what are the effects of the supplementation on inflammatory serum markers? * what are the effects of the…","s":"Recruiting","tr":["Nutrition"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06870331","su":"https://scitrials.org/trial/NCT06870331"},{"n":"NCT05726773","t":"The Effect of Robot Assisted Hand Therapy in Patients With Spinal Cord Injury","d":"Considering the scarcity of studies on robotic hand therapy, it has been seen that larger-scale and long-term follow-up studies are needed. In this study, our aim is to compare the effects of robot-assisted hand therapy and conventional physiotherapy on hand functions and quality of life in patients with spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Hand Movement","Quality of Life","Spasticity"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05726773"},{"n":"NCT04372134","t":"The Effect of rTMS in Patients With Spinal Cord Injury (rTMS:Repetetive Transcranial Magnetic Stimulation)","d":"It is postulated that high frequency repetitive transcranial magnetic stimulation (rTMS) can decrease the corticospinal inhibition and enhance the motor recovery. This study is aimed to investigate the effect of high frequency rTMS on lower extremity motor recovery and gait parameters in patients with chronic motor incomplete traumatic spinal cord injury (SCI).","s":"Completed","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Motor Function","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04372134"},{"n":"NCT03991689","t":"The Effect of Solution-focused Group Therapy for Pain Management in Patients With Spinal Cord Injury","d":"Objective: to verify the effect of solution-focused group therapy (SFBT) on pain management as well as physiological, psychological and social adaptation in patients with spinal cord injury. Setting: for matters of convenience, the samples were collected at medical and rehabilitation centers in Taiwan. Twenty-six patients with spinal cord injuries and neuropathic pain were invited to join the four pain management groups. Method: In the case of patients with spinal cord injury affected by…","s":"Completed","tr":["Rehabilitation"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03991689"},{"n":"NCT06104982","t":"The Effect of Superimposed Electrical Stimulation on Sitting Balance, Respiratory Functions, and Abdominal Muscle Thickness in Complete Spinal Cord Injury","d":"The primary aim of the current study was to investigate the effects of SiFES (superimposed functional electrical stimulation) on sitting balance in patients with complete Spinal Cord Injury (SCI) compared to exercise alone. Additionally, the study aims to investigate improvements in respiratory functions and changes in abdominal muscle thickness measured by ultrasonography (USG) following SiFES treatment. The fundamental questions that investigators want to answer are as follows: * \\[question…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Arm Movement","Breathing Function","Trunk Control"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06104982"},{"n":"NCT07090057","t":"The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children","d":"Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk. If not treated, children with ankle equinus frequently experience reduced function and long-term foot problems, such as pain. Currently, treatment options include surgery or Botulinum toxin (BoNTA) injection into the large calf muscles that point the foot downwards, aiming to reduce their tightness. However, these treatments can be…","s":"Recruiting","tr":["Surgical Procedure"],"o":["Pain Management","Spasticity","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07090057"},{"n":"NCT05725499","t":"The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)","d":"This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back to an upright position). The main questions it aims to answer are: 1. What are the various spinal sites and stimulation parameters that normalize and stabilize blood pressure during an orthostatic…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05725499","su":"https://scitrials.org/trial/NCT05725499"},{"n":"NCT00624988","t":"The Effect of Vibration Therapy on the Bone Density of the Tiba in Patients With Spinal Cord Injury","d":"The purpose of this investigation is to determine the effect of lower limb vibration therapy on bone density in the tibia in patients with spinal cord injury. The second purpose is to assess the neuromuscular junction variability at the motor units of the tibialis anterior muscle after a sequence of lower limb vibration therapy","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength"],"st":["Missouri"],"co":["United States"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00624988","su":"https://scitrials.org/trial/NCT00624988"},{"n":"NCT02127606","t":"The Effect of Whole Body Vibration on Spasticity in Persons With Spinal Cord Injury","d":"Extended periods of tilt table standing have been observed to improve spasticity in individuals with spinal cord injury (SCI). The purpose of this study is to determine the effect of three sessions of whole body vibration while tilt table standing on spasticity in individuals with a complete or incomplete SCI above the neurological level of T10. Participants in this study will undergo whole body vibration while standing on a tilt table for a total of approximately 14 minutes for a total of 3…","s":"Unknown","tr":["Rehabilitation"],"o":["Pain Management","Quality of Life","Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02127606","su":"https://scitrials.org/trial/NCT02127606"},{"n":"NCT05704322","t":"The Effectiveness of the Wim Hof Method in People with Spinal Cord Injury","d":"People with a spinal cord injury (SCI) often experience secondary medical complications. One of the methods that may help to prevent or deal with secondary complications in people with SCI is the Wim Hof Method (WHM). The WHM is based on three elements: 1) breathing exercises, 2) gradual cold exposure (cold showers, or cold water immersion), and 3) mindset. The primary objective of this randomized controlled trial is to assess the effects of WHM, involving breathing exercises, mindset (and cold…","s":"Completed","tr":[],"o":["Blood Pressure","Breathing Function","Mental Health","Pain Management","Quality of Life","Spasticity"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05704322"},{"n":"NCT07578532","t":"The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury","d":"The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female patients aged 18-65 with suprasacral Spinal Cord Injury (SCI) whose DOA is confirmed by urodynamics and is refractory to anticholinergic medication. The main question(s) aims to answer : Is there a difference between SMS and SES in their effect on objective urodynamic…","s":"Recruiting","tr":["Electrical Stimulation","Transcranial Magnetic Stimulation (TMS)","Transcutaneous Stimulation"],"o":["Bladder Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07578532","su":"https://scitrials.org/trial/NCT07578532"},{"n":"NCT05330052","t":"The Effects of a Powered Knee Orthosis on Gait Kinematics of Children With Knee Extension Deficiency","d":"Crouch gait/walking, characterized by an 'over-flexed' knee when the leg is supporting body weight, is common in children with diagnoses of cerebral palsy, spina bifida and other incomplete spinal cord injuries. The \"Agilik\" is a leg exoskeleton device that aims to improve how children with crouch gait walk. In this study the investigators will quantify the improvement that the Agilik facilitates in children with crouch gait in two ways: 1) the difference the Agilik makes when the participants…","s":"Completed","tr":["Devices","Exoskeleton","Rehabilitation"],"o":["Leg Movement","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05330052"},{"n":"NCT06274658","t":"The Effects of an Acute High-intensity Exercise on Heart and Brain Function in People With Spinal Cord Injury","d":"The heart and brain are regulated by the autonomic nervous system. Control of these organs can be disrupted in people with spinal cord injury (SCI). This may affect their ability to regulate blood pressure during daily activities and process the high-level information. Previous studies show that high-intensity exercise induces better outcomes on heart and information processing ability in non-injured people compared to moderate-intensity exercise. However, it is unknown the effects of…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06274658","su":"https://scitrials.org/trial/NCT06274658"},{"n":"NCT02863315","t":"The Effects of Anodal tsDCS on Chronic Neuropathic Pain After SCI","d":"The purpose of this study is to evaluate the analgesic effect of transcutaneous spinal direct current stimulation (tsDCS) applied on spinal cord in patients with spinal cord injury who have chronic neuropathic pain.","s":"Unknown","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02863315","su":"https://scitrials.org/trial/NCT02863315"},{"n":"NCT01904591","t":"The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study","d":"This study will enroll 10 adults with a chronic spinal cord injury. The investigators will image their damaged motor tracts using MRI tractography scanning, and the investigators will formally assess their ASIA motor level at the outset of the study. Then, the investigators will treat them with one year of 'over the counter' dosage of selenium and vitamin E. These are two vitamins known to be anti-oxidants. After one year the investigators will repeat the MRI scans and ASIA assessments to…","s":"Completed","tr":[],"o":["Motor Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01904591"},{"n":"NCT06429631","t":"The Effects of CIC Training With a Mobile Application on Quality of Life and Compliance in Spinal Cord Injury Patients: a Single Blind Randomized Controlled Study","d":"Neurogenic bladder is a condition that occurs due to nerve damage or congenital problems and causes urination disorders. Nowadays, in individuals diagnosed with neurogenic bladder, Clean Intermittent Catheterization is often used to evacuate the urine accumulated in the bladder. Clean Intermittent Catheterization(CIC) is a simple, safe and effective method in which the catheter is placed through the meatus. In this application, the catheter is removed without waiting after urine drainage is…","s":"Completed","tr":["Devices"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06429631"},{"n":"NCT06905470","t":"The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation","d":"The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation. The main questions this trail aims to answer are: * what are the effects of the training on upper body strength, aerobic performance, muscle volume, functional independence, and health-related quality of life? * is the KREHA training feasible to implement into the…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":["Arm Movement"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06905470","su":"https://scitrials.org/trial/NCT06905470"},{"n":"NCT01232907","t":"The Effects of L-carnitine on Fatigue in Spinal Cord Injury","d":"1. Purpose: To explore the use of L-Carnitine, a pharmaceutical product, for the treatment of fatigue in persons with spinal cord injury (SCI). 2. Hypothesis: Similar to previous research in disabled and aging populations, the investigators hypothesize that treatment with L-Carnitine will result in a significant improvement of clinical fatigue in spinal cord injury clients, effecting a decrease on the Fatigue Severity Scale (FSS) of 0.5 points or more. The investigators expect to see an effect…","s":"Completed","tr":["Drugs"],"o":["Mental Health","Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01232907"},{"n":"NCT02893553","t":"The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury","d":"Dysregulation of blood pressure (BP), secondary to decentralized autonomic nervous system (ANS) control of the cardiovascular system, often results in chronic hypotension and orthostatic hypotension (OH) in persons with spinal cord injury (SCI), particularly in those with high cord lesions (i.e., above T6). While most hypotensive individuals with chronic SCI remain asymptomatic and do not complain of symptoms associated with cerebral hypoperfusion, evidence of reduced resting cerebral blood…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Quality of Life"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02893553"},{"n":"NCT01349478","t":"The Effects of Passive Gait Training in Complete Motor Spinal Cord Injury (SCI)","d":"The purpose of this study is to determine whether a three times per week, 2 month robotic assisted treadmill gait training program, will beneficially affect the fitness, physical and psychological well-being, and the vascular and metabolic cardiovascular risk factors in individuals with complete motor Spinal Cord Injury (SCI).","s":"Completed","tr":["Electrical Stimulation","Rehabilitation"],"o":["Blood Pressure","Leg Movement","Mental Health","Walking Function"],"st":[],"co":["Israel"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01349478"},{"n":"NCT06188130","t":"The Effects of rTMS and tDCS Combined With Robotic Rehabilitation In Patients With Spinal Cord Injury","d":"The purpose of this study is to assess the effect of rTMS and tDCS combined with robotic therapy on motor functional recovery and gait parameters","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06188130","su":"https://scitrials.org/trial/NCT06188130"},{"n":"NCT03690726","t":"The Effects of rTMS in Rehabilitation Following Spinal Cord Injury","d":"The project will investigate whether repetitive transcranial magnetic stimulation (rTMS) can be used to potentiate/prime spinal cord injured patients' nervous systems for more intense rehabilitation exercise of longer duration - thus leading to greater recovery of motion function. The technique, in which a magnetic coil is positioned above the scalp and forms a magnetic field that activates the desired center of the brain (eg motor cortex), is used in clinical practice for the treatment of a…","s":"Completed","tr":["Devices","Rehabilitation","Transcranial Magnetic Stimulation (TMS)"],"o":["Leg Movement","Motor Function","Pain Management","Spasticity","Walking Function"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03690726"},{"n":"NCT03859960","t":"The Effects of Spasticity on Glucose Metabolism in Individuals With Spinal Cord Injury","d":"Muscle atrophy may occur in individuals with spinal cord injury (SCI) as a result of diminished physical activity and alterations in glucose metabolism and body composition may be seen. In a few studies, it has been suggested that spasticity may have a positive impact on glucose metabolism by preventing muscle atrophy and alterations in body composition in individuals with motor complete SCI. Investigators aimed to assess the effects of spasticity on glucose metabolism and body composition in…","s":"Completed","tr":["Observational"],"o":["Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03859960"},{"n":"NCT01781065","t":"The Effects of Transcranial Direct Current Stimulation on Central Pain in Patients With Spinal Cord Injury","d":"The purpose of this study is to evaluate the analgesic effect of transcranial direct current stimulation (tDCS) applied on motor cortex in patients with spinal cord injury who have chronic neuropathic pain.","s":"Completed","tr":["Devices","Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01781065"},{"n":"NCT01244594","t":"The Effects of Two Functional Electrical Stimulation Cycling Paradigms","d":"Background: People with spinal cord injury (SCI) are at risk for many health conditions, some of which can be decreased with exercise. Cycling with Functional Electrical Stimulation (FES) is one way to obtain exercise after SCI. However, cycling with FES has only been done one way, which involves pedaling more quickly with less force to work against. Pedaling more slowly would allow the person to work against more force, which may lead to greater improvements in bone mineral density and muscle…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Nutrition","Rehabilitation"],"o":["Blood Pressure","Bone Strength","Motor Function","Regeneration","Sensory Function"],"st":["Pennsylvania"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01244594"},{"n":"NCT02573402","t":"The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury","d":"The purpose of this research study is to evaluate the effects upon the bladder of electric stimulation of the leg's tibial nerve in people with acute spinal cord injury with an intervention called transcutaneous tibial nerve stimulation (TTNS).","s":"Completed","tr":["Transcutaneous Stimulation"],"o":["Bladder Function","Pain Management"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02573402"},{"n":"NCT03548649","t":"The Efficacy and Safety of a New Power Exoskeleton Robot for Improving Walking Ability in Spinal Cord Injury Patients","d":"In Taiwan, there are more than 23,000 individuals with spinal cord injuries (SCI, mean age: 27 years), with an increment of new 1,200 SCI individuals each year. Recovery of ambulatory function is among the most important therapeutic goals because 92% of the individuals with SCI have to use the wheelchair for the rest of their lives. The lower limb powered exoskeleton robot, FREE Walk, used for training in this research was developed by FREE Bionics Inc. The main purpose of this research is to…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03548649","su":"https://scitrials.org/trial/NCT03548649"},{"n":"NCT03029442","t":"The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury","d":"The purpose of this study is to determine the usefulness of a drug, denosumab, to prevent the loss of bone in participants legs due to SCI. This drug is FDA approved to treat osteoporosis in women after menopause who have an increased risk for fractures, to treat women receiving certain treatments for breast cancer who have an increased risk of fractures, and to treat bone loss in men receiving certain treatments for prostate cancer who have increased risk for fractures. This drug is considered…","s":"Terminated","tr":["Drugs"],"o":["Bone Strength","Quality of Life"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03029442"},{"n":"NCT03857672","t":"The Efficacy of Hypnotic Cognitive Therapy for Chronic Pain in SCI","d":"Chronic pain is prevalent and disabling in people with spinal cord injury (SCI). Medications alone often do not cure the pain. Pilot research suggests that training in the combination of self-hypnosis and cognitive therapy (HCT) can reduce chronic SCI-related pain. Thus far, people have learned HCT only through in-person training sessions plus home practice. The investigators think that training in HCT could be as effective if the training is done via videoconferencing. The purpose of this…","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03857672"},{"n":"NCT04855812","t":"The Efficacy of Upper Extremity Wearable Robotic Orthosis on Improving Upper Extremity Motor Function and Activities of Daily Living in Persons With Spinal Cord Injury","d":"To evaluate the usefulness of an upper extremity (UE) assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury (iSCI)","s":"Completed","tr":["Devices"],"o":["Arm Movement","Motor Function","Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04855812"},{"n":"NCT05954845","t":"The Enteric Nervous System in Spinal Cord Injury: Study of the Enteric Nervous System and the Intestinal Epithelial Barrier Via Colonic Biopsies in Spinal Cord Injury Patients","d":"The goal of this clinical trial is to learn more about the enteric nervous system (ENS) and the intestinal epithelial barrier (IEB) in patients with spinal cord injury (SCI). The main questions it aims to answer are : * to characterize the functional (permeability, serotonin production, enteric neuronal phenotype, etc.), proteomic (junction molecules) and transcriptomic (inflammation genes, neuromediator expression, etc.) remodeling of the colonic mucosa and ENS in SCI patients, in comparison…","s":"Recruiting","tr":[],"o":[],"st":[],"co":["France"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05954845","su":"https://scitrials.org/trial/NCT05954845"},{"n":"NCT06873529","t":"The Experiences of Women With Spinal Cord Injury Regarding Fertility, Contraception and Pregnancy","d":"The aim of this study was to investigate the experiences of women with spinal cord injury regarding fertility, contraception and pregnancy.","s":"Completed","tr":["Observational"],"o":["Sexual Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06873529"},{"n":"NCT03690700","t":"The Feasibility and Effects of Low-load Blood-flow Restricted Exercise Following Spinal Cord Injury","d":"Spinal cord injury (SCI): The World Health Organization estimates an incidence of 250,000 to 500,000 per year worldwide. In Denmark 130 new cases of SCI per year. SCI is a devastating condition: paresis/paralysis of the skeletal muscles below the injury site, partial or complete inability to walk, move and/or feel. Other sequelae are: infections, lifestyle diseases (cardiovascular, diabetes, nephrologic disease), mental wellbeing/suicide-risk profoundly raised , quality of life, next-of-kin…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03690700","su":"https://scitrials.org/trial/NCT03690700"},{"n":"NCT07073144","t":"The Impact of 'Digital Strolling' on Depression and Quality of Life of People With Severe Mobility Impairment","d":"This intervention aims to develop and test the feasibility, acceptability, and preliminary effects of a \"Digital Strolling\" intervention among people with SMI. The intervention group will receive a \"Digital Strolling\" intervention, which consists of 20 minutes \"Digital strolling\" for 10 days, with lessons occurring once a day. The control group will receive passive observation of virtual walking videos only.","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life","Walking Function"],"st":[],"co":["Hong Kong"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07073144"},{"n":"NCT04426071","t":"The Impact of a Societal Lockdown on Those With Spinal Cord and Brain Injuries","d":"Document and evaluate the impact of societal restrictions due to the pandemic on SCI- and ABI-related disability and functional impairments, and the resultant effects on psychological wellbeing, physical wellbeing and quality of life for those with SCI/ABI.","s":"Completed","tr":["Observational"],"o":["Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04426071"},{"n":"NCT04735887","t":"The Impact of an Evidence-Informed Spinal Cord Injury Activities of Daily Living Educational Manual","d":"This study argues that providing evidence-based occupational therapy patient education is vital in order to optimize rehabilitation outcomes. The planned trial aims to evaluate the SADL-eM intervention for people with SCI compared with standard treatment.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Palestinian Territories"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04735887","su":"https://scitrials.org/trial/NCT04735887"},{"n":"NCT02938130","t":"The Impact of Community-based Wellness Programs on The Triple Aim","d":"People with disabilities experience a staggering incidence of secondary conditions that can result in death or negatively impact their health, participation in the community, and quality of life. Many of these chronic secondary conditions are preventable. The Institute for Healthcare Improvement has advocated for optimizing care through programs that simultaneously improve health and the patient experience of care, while reducing cost, called the \"Triple Aim.\" Studies have shown that the Triple…","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02938130","su":"https://scitrials.org/trial/NCT02938130"},{"n":"NCT03909958","t":"The Impact of Electroacupuncture on Clinical Effect,Brain Structural and Functional Changes on Spinal Cord Injury","d":"Spinal cord injury (SCI) is a kind of severe disease with high morbidity and complications. At present, electroacupuncture has certain advantages in treating motor sensory dysfunction, neuropathologic pain, neurogenic bladder and intestinal dysfunction after spinal cord injury. However, previous clinical studies of acupuncture neglected the brain, which is closely related to the structure and function of spinal cord.So,the aim of this study is to observe and analyse the impact of the changes of…","s":"Unknown","tr":["Rehabilitation"],"o":["Bladder Function","Pain Management","Spasticity"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03909958"},{"n":"NCT06147258","t":"The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury","d":"The aim of this study is to evaluate the therapeutic benefits of a 10-week online coach-guided EEWP on psychosocial health among adults with SCI.","s":"Recruiting","tr":[],"o":["Mental Health"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06147258","su":"https://scitrials.org/trial/NCT06147258"},{"n":"NCT04964362","t":"The Impact of Injustice Appraisals on Psychosocial Outcomes Following Spinal Cord Injury: A Longitudinal Study","d":"The primary objectives of this study are to: (1) determine the longitudinal course and impact of injury-related injustice appraisals among civilians and Veterans who have recently acquired a spinal cord injury (SCI), and (2) use qualitative inquiry to gain a rich, contextual understanding of appraisals of injustice during the first year after acquired SCI. The long-term goal of this research is to inform the development of new treatment approaches targeting appraisals of injustice.","s":"Completed","tr":[],"o":["Mental Health"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04964362","su":"https://scitrials.org/trial/NCT04964362"},{"n":"NCT06509841","t":"The Impact of Jiaji Electroacupuncture and Scalp Electroacupuncture on Traumatic Spinal Cord Injury","d":"Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden. This trial aims to compares Jiaji electroacupuncture (JEA) and scalp electroacupuncture (SEA) in SCI rehabilitation. This randomized controlled trial (RCT) compared JEA and SEA in SCI rehabilitation.","s":"Completed","tr":["Rehabilitation"],"o":["Bladder Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06509841"},{"n":"NCT03384017","t":"The Impact of Transcutaneous Spinal Cord Stimulation (TSCS) and Gait Training on Walking Function in Patients With Spinal Cord Injury","d":"Aim 1: Determine the neurophysiologic impact of Transcutaneous Spinal Cord Stimulation (TSCS) within a single session. The investigators hypothesize that subjects will demonstrate increased volitional muscle activity and strength with TSCS. This will be assessed by surface EMG and hand-held dynamometry of the dominant-side quadriceps muscle during maximum volitional contraction (MVC) and measurement of gait speed. Subjects will be tested in both TSCS and sham conditions. Aim 2: Determine the…","s":"Completed","tr":["Devices","Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Motor Function","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03384017"},{"n":"NCT06954688","t":"The Influence of Dry Needling for Hypertonia and Spasticity Treatment on Neuropathic Pain in Lower Extremity of Spinal Cord Injury: A Case Series Study","d":"Spinal cord injury is a life-changing event that places a burden on the healthcare system, including caregivers and affected individuals. Studies do not provide a conclusive incidence rate due to methodological differences. However, a trend observed in recent years is an increasing incidence among the elderly population due to falls or non-traumatic spinal cord injury. The clinical consequences of spinal cord injury include pain and spasticity, in addition to loss of function and activity. On…","s":"Terminated","tr":["Rehabilitation"],"o":["Leg Movement","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Belgium"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06954688"},{"n":"NCT02138110","t":"The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury","d":"This is an HDE probable benefit, open-label, non- randomized, single-arm, multicenter study to evaluate the safety and probable benefit of the poly(lactic-co-glycolic acid)-b-poly(L-lysine) Scaffold (\"Scaffold\") in subjects with thoracic AIS A traumatic spinal cord injury at neurological level of injury of T2-T12.","s":"Terminated","tr":["Devices"],"o":["Motor Function","Sensory Function"],"st":["Arizona","California","New Jersey","North Carolina","Oregon","Pennsylvania"],"co":["United States"],"lc":8,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02138110"},{"n":"NCT06839300","t":"The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study","d":"To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.","s":"Recruiting","tr":["Observational"],"o":[],"st":["Wisconsin"],"co":["Australia","Brazil","Chile","Germany","India","New Zealand","United Kingdom","United States"],"lc":8,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06839300","su":"https://scitrials.org/trial/NCT06839300"},{"n":"NCT02769416","t":"The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury","d":"The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.","s":"Enrolling by invitation","tr":["Observational"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02769416","su":"https://scitrials.org/trial/NCT02769416"},{"n":"NCT00790361","t":"The Natural History of Traumatic Spinal Cord Injury Using fMRI, MRS and DTI","d":"Traumatic spinal cord injury is a common injury to the spine and can lead to a clinical syndrome called central cord syndrome (CCS). CCS is an incomplete spinal cord injury where one starts to lose more motor function in the upper rather than lower extremities. It affects a wide range of the population from the young to the old. However, the natural history of CCS is poorly understood. Research has shown that the injury resulting in CCS might be due to the pinching or compressing of the spinal…","s":"Completed","tr":["Observational"],"o":["Motor Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00790361"},{"n":"NCT03505463","t":"The Neuroinflammatory Response and Biomarkers in Acute Traumatic Spinal Cord Injury","d":"The study is a prospective cohort study designed to assess the diagnostic and prognostic potential of biomarker measurement in acute traumatic spinal cord injury (TSCI), and to examine the neuroinflammatory response to acute TSCI.","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03505463","su":"https://scitrials.org/trial/NCT03505463"},{"n":"NCT06726135","t":"The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study","d":"Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated outcomes within a cohort of Major Trauma patients between 2015 and 2018 using data from two of these datasets. The NCASRI project outlined some of the shortcomings of the pre-existing datasets and highlighted the need for a single National Rehabilitation Dataset to provide…","s":"Not yet recruiting","tr":["Observational","Rehabilitation"],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06726135"},{"n":"NCT06552507","t":"The Outcome of Injured Cervical Spinal Cord with Uncontrolled Swelling Under Duraplasty","d":"Overall Objective: To assess whether incorporating duraplasty alongside bony decompression enhances motor function outcomes in individuals following Traumatic Spinal Cord Injury (TSCI). Rationale for Research: In a systematic review, individuals suffering from cervical Traumatic Spinal Cord Injuries (TSCIs) identified specific priorities for improvement in their quality of life. These priorities encompassed enhanced arm and hand function, improved bladder and bowel control, sexual function, and…","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06552507","su":"https://scitrials.org/trial/NCT06552507"},{"n":"NCT07695662","t":"The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury","d":"The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper sacral spinal cord injury . The main questions it aims to answer are: Is increased lower extremity muscle tone independently associated with the presence of detrusor overactivity after adjusting for age, sex, injury level, injury type, and injury cause? Does the predictive…","s":"Not yet recruiting","tr":["Observational"],"o":["Bladder Function","Leg Movement","Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07695662"},{"n":"NCT05829837","t":"The Relationship Between Ambulation Capacity and Piriformis Muscle in Patients With Chronic Spinal Cord Injury","d":"Spinal cord injury (SCI) is a neurological condition causing paralysis, sensory abolishmentS and deficits including circulatory, respiratory, otonomic nervous systems, bowel and bladder functions. For patients with SCI, reducing disability, limitations of the impairment and regaining the walking ability are the main rehabilitation goals. There many prognostic factors effecting the recovery and ambulation capacity of patients. The piriformis muscle (PM) is placed posterior to the hip joint…","s":"Unknown","tr":["Observational","Rehabilitation"],"o":["Bladder Function","Bowel Function","Breathing Function","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05829837"},{"n":"NCT05319522","t":"The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury","d":"This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and identify an exercise-based means to increase irisin concentrations.","s":"Completed","tr":[],"o":["Bone Strength"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05319522"},{"n":"NCT05997251","t":"The Relationship of DASH and Mediterranean Diet Score With Serum Adiponectin Levels in Patients With Spinal Cord Injury","d":"The aim of this study is to reveal the relationship of DASH and Mediterranean diet score with anthropometric measurements and serum adiponectin level in individuals with spinal cord injury. This research was planned as a cross-sectional, case-control study. With the data to be obtained from the research, information will be obtained about the hormonal or biochemical basis of metabolic disorders such as atherosclerosis and insulin resistance that may occur in individuals with spinal cord injury…","s":"Completed","tr":["Nutrition","Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05997251"},{"n":"NCT01968096","t":"The Reversal of Neuromuscular Adaptation in Human With Spinal Cord Injury II","d":"Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations. In parallel with the spinal circuit adaptation, the muscular properties also adapt. In human and animal studies, histochemical and physiological evidences showed that the paralyzed muscle transferred from slow, fatigue-resistant to fast, fatigable after injury. Reversal of neuromuscular property for persons with SCI needs to be resolved. Studies using high load electrical stimulations showed a reverse…","s":"Unknown","tr":["Devices"],"o":["Motor Function"],"st":[],"co":["Taiwan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01968096","su":"https://scitrials.org/trial/NCT01968096"},{"n":"NCT05503316","t":"The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System","d":"Persons with an injury of the central nervous system clearly experience motor impairments. Among the most commonly described consequences are gait abnormalities and impaired balance. Although these are undeniably linked, they are also influenced by other factors. A recent systematic review (Xie, 2022) reports impaired balance, the presence of depression or anxiety, and decreased function of the lower limbs as important risk factors for fear of falling in persons after a stroke. Also for people…","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Belgium"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05503316","su":"https://scitrials.org/trial/NCT05503316"},{"n":"NCT03670498","t":"The Safety and Efficacy of the 4 Channel NMES on Swallowing","d":"This study is a pilot study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders. The purpose of this study is to investigate the difference in 4ch NMES and 2ch NMES, And to obtain the values such as mean, standard deviation and so on, and to determine the number of subjects to be studied for clinical trials of validation permission in the future.","s":"Completed","tr":["Devices","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03670498"},{"n":"NCT02354625","t":"The Safety of ahSC in Chronic SCI With Rehabilitation","d":"The purpose of this study is to assess the safety of autologous human Schwann cell (ahSC) transplantation in participants with chronic SCI. This trial design is phase I, open label, unblinded, non-randomized, and non-placebo controlled multiple injury cohorts.","s":"Completed","tr":["Rehabilitation","Stem Cells"],"o":["Arm Movement","Bladder Function","Bowel Function","Motor Function","Pain Management","Quality of Life","Sexual Function","Spasticity","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02354625"},{"n":"NCT04748835","t":"The SEEA (SCI Energy Expenditure and Activity) Study","d":"People with SCI are at higher risk of obesity and chronic diseases, such as hypertension, high cholesterol, diabetes and cardiovascular disease, than the general population. Researchers currently lack data on factors that influence weight gain among people with SCI. During this one-year observational study, study staff will enroll 60 individuals with SCI while they are inpatients at Baylor Scott \\& White Institute for Rehabilitation (BSWIR). Data will be collected at 3 time periods (before…","s":"Completed","tr":["Nutrition","Observational","Rehabilitation"],"o":["Blood Pressure","Mental Health"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04748835"},{"n":"NCT05115149","t":"The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments.","d":"The aim of the study is to investigate the effectiveness of a new rehabilitation technology for paralysis that occurs after stroke or spinal cord injury. The research will jointly use a prototype neurorehabilitation orthosis, in which a robotic device moves a paralyzed arm at the command of a non-invasive brain-computer interface to perform a game life-like task augmented using a virtual-reality display, as well as an electrical stimulation device that activates the spinal cord and/or muscles…","s":"Unknown","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Arm Movement"],"st":[],"co":["Russia"],"lc":6,"rlc":6,"cu":"https://clinicaltrials.gov/study/NCT05115149","su":"https://scitrials.org/trial/NCT05115149"},{"n":"NCT03515122","t":"The Swedish Spinal Cord Injury Study on Cardiopulmonary and Autonomic Impairment","d":"The main aim of this study is to gain an in-depth knowledge of cardiopulmonary and autonomic health consequences, and related risk factors among people with long-term high-level spinal cord injury. The result of this study will form the basis for further research to improve prevention strategies and risk prediction of cardiopulmonary disorders in people with spinal cord injury.","s":"Completed","tr":["Observational"],"o":["Blood Pressure","Breathing Function","Mental Health","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Sweden"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03515122"},{"n":"NCT05741788","t":"The Teaspoon Study - Telefitting Spinal Cord Stimulation for Pain","d":"Spinal cord stimulation modulates the nervous system to effectively block pain signals originating from the back and legs. Spinal cord stimulation has been shown to improve chronic pain, improve quality of life, and reduce disability. Unfortunately, spinal cord stimulation has a high trial failure rate and a high long-term failure rate. This study consists of a prospective cohort of patients clinically scheduled to undergo spinal cord stimulation for the treatment of chronic back pain or…","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Pain Management","Quality of Life"],"st":["Minnesota"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05741788"},{"n":"NCT04697472","t":"The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury","d":"The Up-LIFT Study is a prospective, single-arm study designed to evaluate the safety and effectiveness of non-invasive electrical spinal cord stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in people with chronic tetraplegia.","s":"Completed","tr":["Electrical Stimulation"],"o":["Arm Movement","Motor Function"],"st":["Colorado","Florida","Georgia","Massachusetts","Minnesota","New York","Pennsylvania","Washington"],"co":["Canada","Netherlands","United Kingdom","United States"],"lc":14,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04697472"},{"n":"NCT00223769","t":"The Use of Anabolic Steroids to Improve Function After Spinal Cord Injury","d":"The purpose of this study is to determine the effect of oxandrolone on the function and quality of life of patients with chronic spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Arm Movement","Breathing Function","Motor Function","Quality of Life","Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00223769"},{"n":"NCT04050696","t":"The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients","d":"The purpose of this study is to further establish safety and efficacy of the BQ EMF treatment of chronic SCI subjects who demonstrate stability in The Graded and Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) strength score following a one-month physical therapy run-in period.","s":"Unknown","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["Florida","New Jersey"],"co":["Israel","United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT04050696","su":"https://scitrials.org/trial/NCT04050696"},{"n":"NCT05745298","t":"The Use of Functional Electrical Stimulation in Conjunction With Respiratory Muscle Training to Improve Unaided Cough in Individuals With Acute Spinal Cord Injury","d":"The overall objective of this study is to improve unaided cough with abdominal and latissimus dorsi functional electrical stimulation in conjunction with respiratory muscle training in individuals with acute spinal cord injuries.","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05745298","su":"https://scitrials.org/trial/NCT05745298"},{"n":"NCT00223873","t":"The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury","d":"The purpose of this study is to determine the effect of penile vibratory stimulation on the muscle spasticity of men with chronic spinal cord injury.","s":"Completed","tr":[],"o":["Quality of Life","Spasticity"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00223873"},{"n":"NCT06145789","t":"The Use of Standing Powered Wheelchairs in Spinal Cord Injury","d":"The purpose of this study was to explore the experiences of standing powered wheelchair users with spinal cord injury.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06145789"},{"n":"NCT06349434","t":"The Utilization Effects of Powered Wearable Orthotics in Improving Upper Extremity Function and ADL in Persons With SCI","d":"To evaluate the usefulness of an upper extremity assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury. The Department of Defense is supporting this study.","s":"Recruiting","tr":["Devices"],"o":["Arm Movement","Motor Function","Spasticity"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06349434","su":"https://scitrials.org/trial/NCT06349434"},{"n":"NCT02943915","t":"The WISE Trial - Walking Improvement for SCI With Exoskeleton","d":"A randomized, controlled trial comparing exoskeleton gait training with standard gait training or no gait training in community-dwelling participants with chronic incomplete spinal cord injury","s":"Completed","tr":["Exoskeleton","Rehabilitation"],"o":["Trunk Control","Walking Function"],"st":["Arizona","Connecticut","Illinois","Maryland","Michigan","Minnesota","New Jersey","New York","Texas"],"co":["United States"],"lc":10,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02943915"},{"n":"NCT01621984","t":"Therapeutic Riding and Neuromuscular Disease","d":"The purpose of this current prospective study is to assess the effects of a Therapeutic Riding exercise program conducted in patients suffering from neuromuscular disease. The exercise intervention aims at improving gross motor function, gross motor performance, balance, spasticity, posture and quality of life. Patients were randomized according to age, sex, mental ability and gross motor function. Furthermore, patients will be subdivided into categories of central nervous system (brain/ spinal…","s":"Completed","tr":[],"o":["Motor Function","Quality of Life","Spasticity","Trunk Control"],"st":[],"co":["Greece"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01621984"},{"n":"NCT02908867","t":"Therapeutic Strategies in Sexual Function","d":"Objectives: To know the main therapeutic strategies used by men with spinal cord injury in sexual dysfunctions.","s":"Completed","tr":["Observational"],"o":["Sexual Function"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02908867"},{"n":"NCT02713269","t":"Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord","d":"This phase II clinical trial studies how well thermal ablation and spine stereotactic radiosurgery work in treating patients with cancer that has spread to the spine (spine metastases) and is at risk for compressing the spinal cord. Thermal ablation uses a laser to heat tumor tissue and helps to shrink the tumor by destroying tumor cells. Stereotactic radiosurgery delivers a large dose of radiation in a short time precisely to the tumor, sparing healthy surrounding tissue. Combining thermal…","s":"Active, not recruiting","tr":[],"o":["Pain Management","Quality of Life"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02713269"},{"n":"NCT02379156","t":"Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia","d":"The ability to maintain normal core body temperature (Tcore = 98.6°F) is impaired in persons with a cervical spinal cord injury (tetraplegia). Despite the known deficits in the ability of persons with spinal cord injury (SCI) to maintain Tcore, and the effects of hypothermia to impair mental function in able-bodied (AB) persons, there has been no work to date addressing these issues in persons with tetraplegia. Primary Aim: To determine if exposure of up to 2 hours to cool temperatures (64°F)…","s":"Completed","tr":["Drugs"],"o":["Blood Pressure","Temperature Control"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02379156"},{"n":"NCT07136688","t":"Tibial Nerve Stimulation for Pediatric Spina Bifida Neurogenic Bladder","d":"The purpose of this study is to determine the safety, feasibility, and compliance of a daily home transcutaneous tibial nerve stimulation (tTNS) protocol in children with chronic neurogenic bladder (NB) provided by self or caregiver for 4 weeks and to estimate the efficacy of tTNS","s":"Recruiting","tr":["Devices","Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Mental Health","Sensory Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07136688"},{"n":"NCT05003999","t":"Time Needed to Perform Intermittent Catheterization in Adults With Spinal Cord Injuries","d":"This study investigates the burden of intermittent catheterization in adult individuals with neurogenic lower urinary tract dysfunction (NLUTD) following spinal cord injury (SCI). Individuals will be recruited to compare two types of catheters. Each participant will use a non-hydrophilic catheter at one time point and a hydrophilic catheter at a different time point to perform intermittent catheterization. The order that participants use either a non-hydrophilic or a hydrophilic catheter will…","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05003999"},{"n":"NCT04904770","t":"Time Performance of Scoop Stretcher Versus Vacuum Mattress for Prehospital Spinal Stabilization","d":"A simulation-based randomized controlled trial was designed with the objective to assess the time needed to achieve spinal stabilization using a scoop stretcher compared to a vacuum mattress.","s":"Completed","tr":["Devices"],"o":["Mental Health"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04904770"},{"n":"NCT05921487","t":"Time Restricted Eating to Mitigate Obesity in Veterans With Spinal Cord Injury","d":"Spinal cord injury (SCI) causes paralysis and muscle atrophy and leads to weight gain and obesity. Obesity directly contributes to functional impairment and cardiometabolic dysfunction. There is a critical need to reduce the growing prevalence of obesity and cardiometabolic disease after SCI. My overall objective in this project is to gather crucial feasibility data on time restricted eating (TRE), a novel form of intermittent fasting. TRE is a straightforward method to induce weight loss…","s":"Active, not recruiting","tr":["Nutrition"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05921487","su":"https://scitrials.org/trial/NCT05921487"},{"n":"NCT04910204","t":"Time-effect of FEST+TST in the Upper-extremity Rehabilitation of Individuals with Traumatic SCI","d":"The purpose of this study is to investigate whether the timing of delivery of functional electrical stimulation therapy in combination with task-specific training (FEST+TST) following spinal cord injury (SCI) influences functional and neurological recovery.","s":"Not yet recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04910204","su":"https://scitrials.org/trial/NCT04910204"},{"n":"NCT03774043","t":"Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI","d":"This study will utilize short duration and mild levels of reduced oxygen (hypoxia) to induce spinal plasticity while evaluating the appropriate timing schedule for this intervention, as well as, the effects of superimposing sessions of a therapy, in individuals with chronic incomplete SCI. Our aim is to establish the time-course of outcome improvement and decay following a single session or multiple sessions of AIH therapy.","s":"Unknown","tr":["Intermittent Hypoxia"],"o":[],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03774043","su":"https://scitrials.org/trial/NCT03774043"},{"n":"NCT07636135","t":"Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy","d":"The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical spine surgery. The main question it aims to answer is: Does starting rehabilitation earlier improve walking, balance, physical activity, quality of life, and nervous system function after surgery? Researchers will compare participants who begin rehabilitation two weeks…","s":"Recruiting","tr":["Rehabilitation","Surgical Procedure"],"o":["Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07636135"},{"n":"NCT01771159","t":"Tissue Bonding Cystostomy(TBC)","d":"Spinal Cord Injured \\[SCI\\] patients typically cannot \"pee\". Injury to the spinal cord disrupts the in-coming and out-going brain signals that coordinate bladder sensation and the emptying of bladder. SCI typically causes chronic retention of urine with uncontrolled leakage of urine. Some form of tube (catheter) is needed to drain the urine except with the mildest forms of SCI. Two types of tubes to drain the urine have been used for many years. These types are the urethral (inserted into the…","s":"Unknown","tr":[],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01771159","su":"https://scitrials.org/trial/NCT01771159"},{"n":"NCT04988425","t":"TNFα Monoclonal Antibody for Acute Spinal Cord Injury","d":"The purpose of this study is to evaluate the safety and effectiveness of subcutaneous injection of TNFα monoclonal antibody cells for the treatment of traumatic acute spinal cord injury. Spinal cord injury can be divided into three phases, which are acute (within 2 weeks), sub-acute (2 weeks to 6 months), and chronic (over 6 months). The pathological process of spinal cord injury include primary injury (initial traumatic insult) and a progressive secondary injury cascade characterized by…","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04988425","su":"https://scitrials.org/trial/NCT04988425"},{"n":"NCT03670485","t":"To Assess the Safety and Efficacy of the 4 Channel NMES Compensatory Medical Device in Swallowing, Multicenter Study","d":"This study is a confirmation study to prepare clinical trials to evaluate the safety and effectiveness of 4-channel electric stimulation therapy devices as a newly developed function for the treatment of dysphagia disorders. The purpose of this study is to validate the 4ch NMES device.","s":"Completed","tr":["Devices","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":[],"st":[],"co":["South Korea"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03670485"},{"n":"NCT06965101","t":"To Determine Whether it is Feasible to Treat Patients Requiring Urgent Radiotherapy Diagnosed With Metastatic Cord Compression (MSCC) on the Magnetic Resonance Linear Accelerator (MRL) in a Single Appointment and Compare it to the Standard of Care Radiotherapy Pathway","d":"The goal of this clinical trial is to understand whether the Magnetic Resonance Linear Accelerator (MRL) could expedite Radiotherapy treatment for Metastatic Cord Compression (MSCC) by removing the need for a planning CT (pCT) scan prior to treatment. Radiotherapy will be delivered in one appointment on the MRL and compared to the standard of care of two appointments: a CT scan and a Radiotherapy appointment. The main questions it aims to answer are: * Can the MRL deliver successful treatment…","s":"Recruiting","tr":[],"o":["Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06965101"},{"n":"NCT00141375","t":"To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.","d":"To evaluate long-term safety and efficacy of pregabalin in the treatment of neuropathic pain after spinal cord injury.","s":"Completed","tr":["Drugs"],"o":["Pain Management"],"st":[],"co":["Australia"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00141375"},{"n":"NCT01730183","t":"To Study the Safety and Efficacy of Autologous Bone Marrow Stem Cells in Patients With Spinal Cord Injury","d":"This is a Phase I/II, multicenter, prospective, non-randomized, open label study to evaluate the safety/efficacy of autologous bone marrow-derived stem cell transplantation in spinal cord injury patients.","s":"Unknown","tr":["Stem Cells"],"o":["Motor Function","Sensory Function"],"st":[],"co":["India"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01730183","su":"https://scitrials.org/trial/NCT01730183"},{"n":"NCT06998134","t":"Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults","d":"People with cerebral palsy (CP), muscular dystrophy (MD), spina bifida, or spinal cord injury often have muscle weakness, and problems moving their arms and legs. The NIH designed a new brace device, called an exoskeleton, that is worn on the legs and helps people walk. This study is investigating new ways the exoskeleton can be used in multiple settings while performing different walking or movement tasks, which we call ubiquitous use. For example, we will ask you to walk on a treadmill at…","s":"Recruiting","tr":["Devices","Electrical Stimulation","Exoskeleton","Functional Electrical Stimulation (FES)","Observational"],"o":["Leg Movement","Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06998134"},{"n":"NCT06643312","t":"TPAD for Recovery of Standing After Severe SCI","d":"The purpose of this study is to investigate how standing and sitting balance control is altered after spinal cord injury (SCI) and how a new type of robotic assistive device may be used to improve muscle function. This device is called the Tethered Pelvic Assist Device, or TPAD. The main aims are to: 1\\. Examine muscle activation patterns generated during different types of standing in spinal cord injured individuals using robotic assistance or self-assistance for balance 2 and 3. Examine the…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06643312","su":"https://scitrials.org/trial/NCT06643312"},{"n":"NCT04758052","t":"Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placement","d":"There is currently no prospective study analyzing the effect of tracheostomy with bedside simultaneous gastrostomy versus tracheostomy with delayed gastrostomy placement (TSG versus TDG) on the outcomes of neurocritically-ill patients. The investigators will study TSG via concomitant PDT and PUG procedures, while TDG will occur per usual care. This study is a prospective randomized open-label blinded endpoint study to assess the effect of tracheostomy with bedside simultaneous gastrostomy (TSG)…","s":"Withdrawn","tr":["Nutrition"],"o":["Breathing Function"],"st":["Mississippi"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04758052"},{"n":"NCT04412447","t":"Training for Persons With Complete SCI for FES Cycling: a Case Series","d":"The main objective of this study is to validate the effectivity of a simple home-based training for cycling with functional electrical stimulation (FES). The training is designed to progressively increase strength and endurance of the paralysed muscles of a person with complete spinal cord injury. After a limited period of only several months, performance will be assessed during FES-assisted cycling on a recumbent tricycle over flat ground. The outcomes of this study should provide evidence for…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04412447","su":"https://scitrials.org/trial/NCT04412447"},{"n":"NCT02498548","t":"Training of Eccentric Lower Extremity Function After SCI","d":"This project will characterize lower extremity eccentric muscle function among individuals who have undergone locomotor training after spinal cord injury and will evaluate the effect of downhill training at moderate speeds - targeted to rehabilitation eccentric function of the knee or hip.","s":"Completed","tr":["Rehabilitation"],"o":["Leg Movement","Walking Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02498548"},{"n":"NCT01807728","t":"Training Programs to Improve Outcomes for Individuals With Spinal Cord Injury","d":"The objective of this study is to determine the effectiveness of different training programs on outcomes in persons with spinal cord injury (SCI). We are interested to see which programs have the greatest impact.","s":"Completed","tr":[],"o":["Quality of Life"],"st":["Florida","Illinois","New Jersey","Pennsylvania"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01807728"},{"n":"NCT03322202","t":"Training Therapists in Motivational Interviewing","d":"The purpose of this study is to test the efficacy of a Motivational Interviewing intervention on therapy participation as performed by physical and occupational therapists in an inpatient setting with patients with spinal cord injuries.","s":"Unknown","tr":[],"o":["Quality of Life"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03322202"},{"n":"NCT04627168","t":"Trancutaneous Abdominal Stimulation on Bowel Function.","d":"This is a prospective, single-center, feasibility study to determine the sensations elicited by non-invasive abdominal electrical stimulation and its effects on bowel function in spinal cord injured individuals and in able-bodied persons with chronic constipation. Electrical stimulation will be delivered through commercially available equipment to each subject during a single site visit.","s":"Unknown","tr":[],"o":["Bowel Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04627168","su":"https://scitrials.org/trial/NCT04627168"},{"n":"NCT01874782","t":"Transcranial Electrical Stimulation for Management of Orthostatic Instability in Acute Cervical Spinal Cord Injury","d":"Individuals with acute cervical spinal cord injury (SCI) can suffer from an excessive and prolonged fall in blood pressure when assuming an upright position, such as transitioning from lying to sitting or standing, a condition also known as orthostatic hypotension (OH). Due to a decrease in cerebral oxygenation, affected individuals can develop debilitating symptoms including lightheadedness, blurred vision, fatigue and even loss of consciousness. Recent evidence suggests that OH has a negative…","s":"Completed","tr":["Devices","Electrical Stimulation","Rehabilitation"],"o":["Blood Pressure","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01874782"},{"n":"NCT02914418","t":"Transcranial Magnetic Stimulation (TMS) for Upper Limb Dysfunction in Spinal Cord Injury: a Feasibility Study","d":"This study will investigate how repetitive transcranial magnetic stimulation (TMS) using intermittent theta-burst stimulation (iTBS) paradigm affects sensorimotor dysfunction such as pain, spasticity, motor weakness and sensory loss. TMS is technique which allows non-invasive stimulation of the cortex, and can modulate activity of neurons. The purpose of this study will be to assess the feasibility of using TMS with iTBS paradigm to treat sensorimotor dysfunction in people with incomplete…","s":"Completed","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Arm Movement","Leg Movement","Motor Function","Pain Management","Quality of Life","Sensory Function","Spasticity"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02914418"},{"n":"NCT05593237","t":"Transcranial Magnetic Stimulation for Chronic Neuropathic Pain","d":"Chronic neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system. It is highly prevalent, debilitating, and challenging to treat. Current available treatments have low efficacy, high side effect burden, and are prone to misuse and dependence. Emerging evidence suggests that the transition from acute to chronic neuropathic pain is associated with reorganization of central brain circuits involved in pain processing. Repetitive transcranial magnetic…","s":"Active, not recruiting","tr":["Devices","Transcranial Magnetic Stimulation (TMS)"],"o":["Mental Health","Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05593237"},{"n":"NCT05645003","t":"Transcranial Magnetic Stimulation Therapy in Neuropathic Painful Spinal Cord Injury Patients","d":"The aim of our study is to investigate the effect of high-frequency Repetitive Transcranial Magnetic Stimulation(rTMS) therapy applied to the dorsolateral PFC (DLPFC) area on neuropathic pain in patients with spinal cord injury. In this area, there are very few studies on the effectiveness of rTMS treatment added to medical treatment in neuropathic pain. In addition, the number of studies comparing the effect of rTMS therapy applied to the DLFPC area is very few.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Pain Management"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05645003","su":"https://scitrials.org/trial/NCT05645003"},{"n":"NCT06493071","t":"Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI","d":"Spinal cord injury (SCI) has been shown to be associated with impairment to the autonomic nervous system in the form of reduced activity of a key nerve known as the vagus nerve. As the vagus nerve has an important role in regulating inflammation and is associated with depression, it may represent a key mechanism which contributes to chronic inflammation and depression following SCI. A technique known as transcutaneous auricular vagus nerve stimulation (taVNS) can stimulate the vagus nerve…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Mental Health"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06493071","su":"https://scitrials.org/trial/NCT06493071"},{"n":"NCT07588711","t":"Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury","d":"This pilot randomized, double-blind, sham-controlled clinical investigation will evaluate the feasibility and safety of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with spinal cord injury (SCI) and neuropathic pain. Participants will be randomized to receive either active taVNS targeting the auricular branch of the vagus nerve or sham taVNS delivered to the earlobe. Primary outcomes include feasibility, safety, adherence, acceptability…","s":"Not yet recruiting","tr":["Electrical Stimulation"],"o":["Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07588711","su":"https://scitrials.org/trial/NCT07588711"},{"n":"NCT05852379","t":"Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury","d":"This study is a single blinded prospective randomized monocentric study examining the effectiveness of transcutaneous auricular vagus nerve stimulation paired with rehabilitation and low frequency/antidromic stimulation of the pelvic somatic nerves. The investigator hypothesize that treatment using transcutaneous auricular vagus nerve stimulation will improve gait recovery in spinal cord injured participants already treating by rehabilitation and pelvic nerves neuromodulation.","s":"Unknown","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Leg Movement","Walking Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05852379"},{"n":"NCT01949285","t":"Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs","d":"This study is to determine if non-invasive electrical stimulation of the spinal cord can be used to: 1) assess spared function following a spinal cord injury; and 2) be use for rehabilitation.","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01949285"},{"n":"NCT03184792","t":"Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury","d":"Stimulation of the spinal cord may induce the growth and reorganization of neural pathways leading to the re-animation of paralyzed limbs. Growing evidence indicates that electrical spinal cord stimulation improves motor functions immediately via modulating the excitability of spinal circuitry in patients with spinal cord injury. Recently, a novel, non-invasive, well-tolerated and painless transcutaneous electrical stimulation strategy was demonstrated to be effective for improving lower limb…","s":"Completed","tr":["Devices","Drugs","Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement","Leg Movement","Motor Function","Pain Management","Quality of Life","Sensory Function"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03184792"},{"n":"NCT04506099","t":"Transcutaneous Intercostal Nerve Stimulation in Spinal Cord Injury","d":"The purpose of this study is to determine the safety, feasibility, and effectiveness of electric stimulation of the nerves along the intercostal nerves on pain and spasticity in spinal cord injury patients.","s":"Withdrawn","tr":["Transcutaneous Stimulation"],"o":["Pain Management","Spasticity"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04506099"},{"n":"NCT06802640","t":"Transcutaneous Spinal Cord Electrical Stimulation Combined With Kunming Locomotor Training for the Treatment of Spinal Cord Injury","d":"Spinal cord injury (SCI) is a common and severe traumatic central nervous system injury in clinical practice. Currently, the treatment of SCI remains a worldwide challenge.International studies have confirmed that TSCS is an effective non-invasive technique to activate the body's movement-related circuits. This method utilizes a unique stimulation waveform that is transmitted through electrodes placed on the skin of the spine and spreads through the dorsal roots (DRs) to activate the spinal…","s":"Not yet recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06802640","su":"https://scitrials.org/trial/NCT06802640"},{"n":"NCT04858178","t":"Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes","d":"This study looks to characterize autonomic nervous system dysfunction after spinal cord injury and identify the potential role that transcutaneous spinal cord stimulation may play at altering neuroregulation. The autonomic nervous system plays key parts in regulation of blood pressure, skin blood flow, and bladder health- all issues that individuals with spinal cord injury typically encounter complications. For both individuals with spinal cord injury and uninjured controls, experiments will…","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function","Blood Pressure"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04858178"},{"n":"NCT07445685","t":"Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.","d":"The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury. It will also learn about the safety of transcutaneous spinal cord stimulation when combined with assisted cycling training. The main questions it aims to answer are: Does transcutaneous spinal cord stimulation while training with assisted cycling improve lower limb motor function? Does transcutaneous spinal cord…","s":"Not yet recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07445685","su":"https://scitrials.org/trial/NCT07445685"},{"n":"NCT05210166","t":"Transcutaneous Spinal Cord Stimulation and Robotic Therapy","d":"Lumbosacral spinal stimulation activates the neural network involved in the control of locomotion at the spinal level. However, its effects are limited to the production of robust rhythmic patterns of alternating movement, being currently in the absence of therapeutic value. On the other hand, the use of robotic technology for gait rehabilitation has experienced significant growth during the last years and its clinical efficacy is similar to others traditional interventions.","s":"Completed","tr":["Electrical Stimulation","Rehabilitation","Transcutaneous Stimulation"],"o":["Motor Function","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05210166"},{"n":"NCT06313515","t":"Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI","d":"Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities. The goal of this randomized trial is to test combinatory therapy of moderate arm-crank exercise paired with non-invasive transcutaneous spinal cord stimulation (tSCS) for cardiovascular recovery in adults aged 21-65 following chronic…","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["Washington"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06313515","su":"https://scitrials.org/trial/NCT06313515"},{"n":"NCT06801431","t":"Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury","d":"The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic spinal cord injury admitted to inpatient rehabilitation. The secondary goal is to understand the clinical impact of thoracolumbar spinal cord stimulation on bowel function. Study participants will receive a 10-day course of transcutaneous spinal cord stimulation at…","s":"Not yet recruiting","tr":["Transcutaneous Stimulation"],"o":["Bowel Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06801431","su":"https://scitrials.org/trial/NCT06801431"},{"n":"NCT06596369","t":"Transcutaneous Spinal Cord Stimulation for Upper Extremity Function","d":"Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI). More recently, the use of invasive, epidural electrical stimulation of the spinal cord has also demonstrated promise in restoring upper extremity function post-stroke. However, the effect of stimulation parameters such as electrode configuration and stimulation frequency on excitability of the nervous system remains unknown preventing the…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT06596369","su":"https://scitrials.org/trial/NCT06596369"},{"n":"NCT06838637","t":"Transcutaneous Spinal Cord Stimulation Home Study","d":"The goal of this pilot clinical trial is to examine the safety and feasibility of SCONE as home based therapy for orthostatic hypotension and bowel dysfunction in individuals with spinal cord injury or multiple system atrophy. The main aims of the study are: * To establish a safe protocol for home-based transcutaneous spinal cord stimulation therapy at the research centre * To test the safety and feasibility of home-based transcutaneous spinal cord stimulation therapy on orthostatic hypotension…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure","Bowel Function"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06838637","su":"https://scitrials.org/trial/NCT06838637"},{"n":"NCT06242873","t":"Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury","d":"Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups. Both groups will receive eight-weeks of individualized gait training. We will measure adverse events, including pain and skin irritation, to determine safety as the primary outcome. Hypothesis 1: Administration of TSCS to children in a clinical setting will be safe based on similar safety…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06242873","su":"https://scitrials.org/trial/NCT06242873"},{"n":"NCT05982171","t":"Transcutaneous Spinal Cord Stimulation to Promote Walking Recovery After Spinal Cord Injury","d":"The goal of this clinical trial is to investigate the effects of transcutaneous spinal cord stimulation (TSCS) combined with exoskeleton training, as compared to exoskeleton training alone to improve motor function in individuals with incomplete spinal cord injury who are 12 months or less post-injury. Participants will be randomly assigned to a treatment group (exoskeleton training with TSCS, or exoskeleton training without TSCS). Participants in both groups will undergo a baseline evaluation…","s":"Active, not recruiting","tr":["Exoskeleton","Transcutaneous Stimulation"],"o":[],"st":["Colorado"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05982171","su":"https://scitrials.org/trial/NCT05982171"},{"n":"NCT05504200","t":"Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training","d":"Spinal Cord Injury (SCI) disrupts signals between the brain and the rest of the body, this includes signals needed to control the bladder and bowels. Spinal cord stimulation (SCS) (electrical stimulation through electrodes placed on the skin over the spine) has shown potential to improve bladder function. Additionally pelvic floor muscle training (PFMT), has been shown to help control bladder overactivity and reduce incontinence in people with a SCI. This study will investigate PFMT with SCS…","s":"Completed","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05504200"},{"n":"NCT05921175","t":"Transcutaneous Spinal Cord Stimulation With Robotic Gait Training in Chronic SCI","d":"This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment robotic gait training (RGT) to improve functional mobility in participants with chronic spinal cord injuries. It also evaluate the impact of the tSCS+RGT on health-related quality of life (HRQOL), compared to RGT alone. This is a prospective single-arm crossover study in participants with incomplete chronic traumatic spinal cord injury. 6 subjects with paraplegia and 6 subjects with tetraplegia…","s":"Recruiting","tr":["Exoskeleton","Transcutaneous Stimulation"],"o":[],"st":[],"co":["Singapore"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05921175","su":"https://scitrials.org/trial/NCT05921175"},{"n":"NCT07692191","t":"Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.","d":"Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI). SCI affects motor, sensory and autonomic systems and can cause very limited exercise capacity which then leads to very high rates of obesity, metabolic syndrome, type II diabetes and cardiovascular disease. This randomized controlled study aims to determine whether and how transcutaneous spinal electrical stimulation (TSES) alters acute…","s":"Recruiting","tr":["Electrical Stimulation","Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":[],"co":["Canada"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07692191"},{"n":"NCT03509558","t":"Transcutaneous Spinal Stimulation and Exercise for Locomotion","d":"Growing evidence indicates that electrical spinal cord stimulation improves motor functions both immediately and over the long term via modulating the excitability of spinal circuitry in patients with spinal cord injury. Recently, a novel, non-invasive, well-tolerated, and painless lumbosacral transcutaneous electrical stimulation strategy was demonstrated to be effective in improving lower limb motor function in participants with spinal cord injury. Our current project, cervical transcutaneous…","s":"Recruiting","tr":[],"o":["Walking Function"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03509558","su":"https://scitrials.org/trial/NCT03509558"},{"n":"NCT05457205","t":"Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury","d":"Spasticity develops months after spinal cord injury (SCI) and persists over time. It presents as a mixture of tonic features, namely increased muscle tone (hypertonia) and phasic features, such as hyperactive reflexes (hyperreflexia), clonus, and involuntary muscle contractions (spasms). Spasticity is often disabling because it interferes with hygiene, transfers, and locomotion and can disturb sleep and cause pain. For these reasons, most individuals seek treatments for spasticity after SCI…","s":"Unknown","tr":["Transcutaneous Stimulation"],"o":["Spasticity"],"st":["Mississippi"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05457205","su":"https://scitrials.org/trial/NCT05457205"},{"n":"NCT03975634","t":"Transcutaneous Spinal Stimulation: Safety and Feasibility for Trunk Control in Children With Spinal Cord Injury","d":"Paralysis of trunk muscles and the inability to sit upright is one of the major problems facing adults and children with spinal cord injury (SCI). Activity-based locomotor training has resulted in improved trunk control in children with spinal cord injury, though full recovery is not achieved in all children. Transcutaneous spinal stimulation' (TcStim), a stimulation applied over the skin to the sensory nerves and spinal cord, is a promising tool that may further enhance improvements to trunk…","s":"Completed","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03975634","su":"https://scitrials.org/trial/NCT03975634"},{"n":"NCT04032990","t":"Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury","d":"Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles. The purpose of this project is to test the safety, comfort, and practicality of a new therapy that stimulates the spinal cord to facilitate activation of arm and hand muscles while practicing grasping, pinching, and reaching movements. The long-term goal is to provide better therapies that will improve the ability of children with SCI to…","s":"Enrolling by invitation","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04032990","su":"https://scitrials.org/trial/NCT04032990"},{"n":"NCT05180227","t":"Transcutaneous Stimulation in Spinal Cord Injury","d":"Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving from a laying down position to upright; however, findings in the general population link the RAAS with remodeling and restructuring of the arterial walls. Therefore, intervention to stabilize and normalize blood pressure should be a priority in individuals with spinal…","s":"Completed","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05180227"},{"n":"NCT04350359","t":"Transcutaneous Tibial Nerve Stimulation for Spinal Cord Injury Neurogenic Bladder","d":"The purpose of this study is to determine if electric stimulation to the leg, called transcutaneous tibial nerve stimulation (TTNS), can improve bladder outcomes in acute spinal cord injury.","s":"Completed","tr":[],"o":["Bladder Function"],"st":["District of Columbia","Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04350359","su":"https://scitrials.org/trial/NCT04350359"},{"n":"NCT03965299","t":"Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury","d":"Most patients with spinal cord injury (SCI) develop neurogenic lower urinary tract dysfunction (NLUTD), one of the most devastating sequelae of SCI which ultimately can lead to renal failure. We urgently need an intervention that prevents NLUTD before irreversible damage occurs. Neuromodulation procedures are a promising avenue so that we investigate the effect of transcutaneous tibial nerve stimulation (TTNS) in patients with acute SCI. This nationwide randomized, sham-controlled, double-blind…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Bladder Function"],"st":[],"co":["Switzerland"],"lc":4,"rlc":4,"cu":"https://clinicaltrials.gov/study/NCT03965299","su":"https://scitrials.org/trial/NCT03965299"},{"n":"NCT06351852","t":"Transdermal Administration by a Novel Wireless Iontophoresis Device","d":"Persons with spinal cord injury (SCI) have neurogenic bowel disorders which is associated with significant morbidity. The negative impact of bowel complications is often at the top of the list of problems reported by persons with SCI. Despite the magnitude of the problem of bowel dysfunction in persons with SCI, and the associated reduction in quality of life, this condition has yet to be effectively treated. The investigators have developed a novel dual drug combination to elicit a safe and…","s":"Completed","tr":["Devices","Drugs","Transcutaneous Stimulation"],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06351852"},{"n":"NCT02370862","t":"Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI","d":"Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals report BC routines lasting for more than 1 hour. In past studies, the investigators have shown that a medication called neostigmine (NEO) combined with a medication called glycopyrrolate (GLY) can increase bowel activity and thus, promote bowel movement. The investigators…","s":"Completed","tr":["Drugs"],"o":["Bowel Function","Motor Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02370862"},{"n":"NCT01162915","t":"Transfer of Bone Marrow Derived Stem Cells for the Treatment of Spinal Cord Injury","d":"This study is based on preclinical (animal) studies showing that infusing bone marrow-derived mesenchymal stem cells into the spinal fluid may contribute to improving neurologic function in animal models with spinal cord injuries. Bone marrow (BM) contains several types of stem cells that can produce functional cells. This includes cells that could help the healing process of damaged neurologic tissue. The primary objective of this study is to see if the injection of these cells, obtained from…","s":"Suspended","tr":["Drugs","Stem Cells"],"o":["Sensory Function"],"st":["Louisiana"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01162915"},{"n":"NCT04105114","t":"Transformation of Paralysis to Stepping","d":"The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis. We will determine the effectiveness of combining noninvasive spinal cord stimulation and the administration of buspirone (a monoaminergic agonist) in facilitating locomotor activity in a gravity-neutral apparatus, during body weight supported stepping on a treadmill, when stepping overground, or during full weight bearing…","s":"Active, not recruiting","tr":["Transcutaneous Stimulation"],"o":["Walking Function"],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04105114","su":"https://scitrials.org/trial/NCT04105114"},{"n":"NCT04565366","t":"Transforming Research and Clinical Knowledge in Spinal Cord Injury","d":"The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics of acute traumatic spinal cord injury (SCI). TRACK-SCI seeks to combine high quality care variables with high density physiology data collection to better understand diagnose, characterize, and track the temporal profile of recovery for SCI patients. The…","s":"Enrolling by invitation","tr":["Safety"],"o":[],"st":["California","Ohio","Utah","Washington"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04565366","su":"https://scitrials.org/trial/NCT04565366"},{"n":"NCT04530955","t":"Transitioning to a Valve-Gated Intrathecal Drug Delivery System (IDDS)","d":"Comparing the efficacy of Intracthecal Baclofen dose between the Prometra II and Medtronic SynchroMed II for patients with spasticity and with current a current SyncroMed II pump needing replacement.","s":"Unknown","tr":["Devices","Drugs"],"o":["Spasticity"],"st":["Louisiana"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04530955"},{"n":"NCT02034669","t":"Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment","d":"This study is designed to assess the safety and effect of autologous adipose derived stem cell (ADSCs) transplantation in acute spinal cord injury patients. 1. To assess the safety of autologous ADSCs transplantation in acute spinal cord injury and the complication after ADSCs transplantation. 2. To evaluate the effect of ADSCs isolation and expansion procedure. 3. To determine if functional outcome is improved following ADSCs transplantation in acute spinal cord injury patient, using…","s":"Unknown","tr":["Devices","Drugs","Stem Cells","Surgical Procedure"],"o":["Bladder Function","Bowel Function"],"st":[],"co":["Vietnam"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02034669"},{"n":"NCT02687672","t":"Transplantation of Autologous Bone Marrow or Leukapheresis-Derived Stem Cells for Treatment of Spinal Cord Injury","d":"This is a double-armed, Phase I/II trial aims to compare bone marrow and leukapheresis as sources for purified, autologous CD34+ and CD133+ stem cells (SCs), to be utilized in treatment of patients with chronic complete spinal cord injuries (SCI). The study focuses on the safety and efficacy of transplanting un-manipulated, autologous, purified stem cells into the injured spinal cords of patients.","s":"Unknown","tr":[],"o":["Regeneration"],"st":[],"co":["Jordan"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02687672","su":"https://scitrials.org/trial/NCT02687672"},{"n":"NCT01231893","t":"Transplantation of Autologous Olfactory Ensheathing Cells in Complete Human Spinal Cord Injury","d":"The purpose of this experimental therapy is an assessment of the safety and feasibility of transplantation of autologous olfactory ensheathing glia and olfactory fibroblasts obtained from the olfactory mucosa in patients with complete spinal cord injury.","s":"Unknown","tr":["Rehabilitation","Stem Cells"],"o":["Motor Function"],"st":[],"co":["Poland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01231893","su":"https://scitrials.org/trial/NCT01231893"},{"n":"NCT04807764","t":"Transspinal Stimulation Plus Locomotor Training for SCI","d":"Locomotor training is often used with the aim to improve corticospinal function and walking ability in individuals with Spinal Cord Injury. Excitingly, the benefits of locomotor training may be augmented by noninvasive electrical stimulation of the spinal cord and enhance motor recovery at SCI. This study will compare the effects of priming locomotor training with high-frequency noninvasive thoracolumbar spinal stimulation. In people with motor-incomplete SCI, a series of clinical and…","s":"Completed","tr":["Electrical Stimulation","Exoskeleton","Rehabilitation"],"o":["Mental Health","Motor Function","Plasticity","Spasticity","Trunk Control","Walking Function"],"st":["New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04807764"},{"n":"NCT05423600","t":"Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia","d":"The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities greater than BES+sham TS in persons with chronic, incomplete tetraplegia.","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":[],"st":["Virginia"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT05423600","su":"https://scitrials.org/trial/NCT05423600"},{"n":"NCT04624607","t":"Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI","d":"People with spinal cord injury (SCI) have motor dysfunction that results in substantial social, personal, and economic costs. Uncontrolled muscle spasticity and motor dysfunction result in disabilities that significantly reduce quality of life. Several rehabilitation interventions are utilized to treat muscle spasticity and motor dysfunction after SCI in humans. However, because most interventions rely on sensory afferent feedback that is interpreted by malfunctioned neuronal networks…","s":"Completed","tr":["Electrical Stimulation","Exoskeleton","Rehabilitation"],"o":["Leg Movement","Motor Function","Plasticity","Quality of Life","Spasticity","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04624607"},{"n":"NCT02316067","t":"Traumatic Spinal Cord Injury: Effects of Corporal Suspension and Pendulum Exercises","d":"The purpose of this study was to evaluate the effects of an exercise program proposed by the CHORDATA® Method on the functionality, maximal isometric torque, muscle activity and muscle thickness of trunk muscles in patients with traumatic spinal cord injury. The hypothesis is that the CHORDATA® Method could reduce the deleterious effects of the traumatic spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Trunk Control"],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02316067"},{"n":"NCT00006429","t":"Treadmill Training for Spinal Cord Injury","d":"This is a trial to test whether treadmill training can be used to improve the \"walking\" of patients with partial spinal cord injury. While on the treadmill, patients will be partially supported through the use of a specially designed harness attached to an overhead lift (also called Body Weight Supported Treadmill Training, BWSTT). Patients who enroll in this study will be randomly assigned to either the experimental group, which receives 12 weeks of this specialized treadmill training with…","s":"Completed","tr":["Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":["California","Georgia","Ohio","Pennsylvania"],"co":["Canada","United States"],"lc":7,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00006429"},{"n":"NCT00061295","t":"Treadmill Training With Body Weight Support in Patients With Spinal Cord Injury","d":"Body weight support (BWS) treadmill training uses an overhead harness to give partial support to patients walking on a treadmill. This study will determine whether BWS training is more effective than conventional rehabilitation therapy in improving walking ability in patients with spinal cord injuries (SCI).","s":"Unknown","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT00061295","su":"https://scitrials.org/trial/NCT00061295"},{"n":"NCT06723561","t":"Treating Central Neuropathic Pain With Low Dose Naltrexone for People With Spinal Cord Injury","d":"The goal of this pilot clinical trial is to find out how well low dose naltrexone works for people with pain due to spinal cord injury. The main questions it aims to answer are: will low dose naltrexone reduce pain, and increase the quality of life for people with central neuropathic pain due to spinal cord injury. Hypothesis 1: LDN will decrease the severity of CNP in adult patients with SCI as measured by the Neuropathic Pain Scale (NPS) Hypothesis 2: LDN will improve quality of life of…","s":"Active, not recruiting","tr":[],"o":["Pain Management"],"st":["Wisconsin"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06723561","su":"https://scitrials.org/trial/NCT06723561"},{"n":"NCT03037879","t":"Treating Cognitive Deficits in Spinal Cord Injury","d":"Multiple studies in the spinal cord injury (SCI) population have documented deficits in learning and memory (LM) and processing speed (PS) that adversely impact daily life and the ability to benefit from rehabilitation. The investigators have previously attributed the cognitive deficits demonstrated in the SCI population to low blood pressure (BP) and cerebral blood flow (CBF) and are currently conducting a study to determine the effect of a 30-day elevation in BP (using midodrine hydrochloride…","s":"Completed","tr":["Rehabilitation"],"o":["Blood Pressure"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03037879"},{"n":"NCT03985540","t":"Treating Cognitive Deficits in Traumatic Spinal Cord Injury (SCI)","d":"The purpose of this research study is to investigate the effectiveness of a memory retraining program and a processing speed program in a spinal cord injured (SCI) population. The study is designed to research how well different types of techniques can help people with SCI improve in areas where they might have difficulties such as memory or processing speed, (time it takes to process information provided).","s":"Completed","tr":[],"o":["Quality of Life"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03985540"},{"n":"NCT07465302","t":"Treating Spinal Cord Injury With Early Normobaric Hyperoxia","d":"SpiCoH is a phase IIa, single center, open-label, clinical trial of intermittent normobaric hyperoxia in mechanically ventilated patients with traumatic cervical and/or thoracic spinal cord injury.","s":"Recruiting","tr":["Intermittent Hypoxia"],"o":[],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07465302","su":"https://scitrials.org/trial/NCT07465302"},{"n":"NCT00695149","t":"Treatment for Acute Spinal Cord Injury","d":"This clinical trial aims to treat a damaged spinal cord by injecting your own bone marrow stromal cells (autologous bone marrow stromal cells) into cerebrospinal fluid through the lumbar puncture, and assess the safety and efficacy of the procedure.","s":"Terminated","tr":["Stem Cells"],"o":["Motor Function","Sensory Function"],"st":[],"co":["Japan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00695149"},{"n":"NCT02663310","t":"Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs Rehabilitation","d":"The purpose of this study is to investigate the efficacy of surgical decompression/untethering, combined with weight bearing rehabilitation, on neurological recovery following chronic spinal cord injury.","s":"Unknown","tr":["Surgical Procedure"],"o":["Motor Function"],"st":[],"co":["China"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02663310","su":"https://scitrials.org/trial/NCT02663310"},{"n":"NCT05122325","t":"Treatment for Sexual Dysfunction in Women with Spinal Cord Injury","d":"Women with spinal cord injury frequently experience sexual dysfunction such as disturbances during arousal and an increased time to orgasm. However, little evidence has been found on its therapeutic approach and low adherence. To verify the effectiveness of two interventions: the application of genital vibration and transcutaneous stimulation of the tibial nerve. This is a randomized clinical trial. 54 women will be recruited who suffer from sexual dysfunction.","s":"Enrolling by invitation","tr":["Transcutaneous Stimulation"],"o":["Sexual Function"],"st":[],"co":["Spain"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05122325","su":"https://scitrials.org/trial/NCT05122325"},{"n":"NCT02363361","t":"Treatment of Cervical Spinal Cord Injury With Imatinib - a Safety and Feasibility Study","d":"This is a phase II, single center, open-label, non randomized clinical study to assess the uptake, safety and tolerability of Imatinib in acute Cervical Spinal Cord Injury patients. The aim is to determine if Imatinib reaches sufficient blood levels when given to patients with cervical spinal cord injury, via a gastric feeding tube, and also evaluate the safety and tolerability of this drug treatment.","s":"Unknown","tr":["Safety"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02363361","su":"https://scitrials.org/trial/NCT02363361"},{"n":"NCT00006448","t":"Treatment of Chronic Pain After Spinal Cord Injury (SCI) or Amputation","d":"Pain is a major problem for people after spinal cord injuries and amputations. This is a study to test how pain is affected by adding methadone to a six-week program of weekly physical therapy, relaxation training and counseling. Individuals who qualify for this study will receive a comprehensive medical and physical therapy evaluation.","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Pain Management"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00006448"},{"n":"NCT04263285","t":"Treatment of Depression Post-SCI","d":"Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rTMS). rTMS is a type of non-invasive brain stimulation. Fourteen individuals with a cervical or thoracic level SCI and…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Mental Health"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04263285","su":"https://scitrials.org/trial/NCT04263285"},{"n":"NCT00286520","t":"Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury","d":"The study aims to compare a newly developed system for transanal colonic irrigation (Peristeen Anal Irrigation) with a bowel management regime that does not include irrigation in a prospective, randomized trial in spinal cord lesion patients (SCL- patients) with faecal incontinence and/or constipation. Population; 80 SCL- patients with faecal incontinence and/or constipation from five countries. Focus on: Bowel symptom score Neurogenic Bowel Dysfunction score Symptom related quality of life…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00286520"},{"n":"NCT00735670","t":"Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury","d":"This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI). After several protocol modifications, the purpose of the study is to test the effectiveness of a sub-therapeutic dose of Venlafaxine HCl to reduce mild to moderate symptoms in persons with SCI.","s":"Completed","tr":["Drugs"],"o":["Mental Health"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00735670"},{"n":"NCT01043848","t":"Treatment of Neurogenic Detrusor Overactivity: Early Versus Late Pudendal Nerve Stimulation in Spinal Cord Injury (SCI) Patients","d":"Background: Although a small group, special attention has to be given to lower urinary tract (LUT) dysfunctions in spinal cord injury (SCI) patients, as they also suffer under a loss of motor-sensory function and autonomic regulation next to the severe deficiencies in bladder and bowel control. Autonomic dysregulation linked with LUT dysfunction can cause autonomic dysreflexia with life threatening increases in blood pressure and there is still no concept for an early rehabilitation of bladder…","s":"Withdrawn","tr":["Electrical Stimulation","Rehabilitation"],"o":["Bladder Function","Blood Pressure","Bowel Function","Plasticity","Sensory Function","Spasticity"],"st":[],"co":["Spain","Switzerland"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01043848"},{"n":"NCT06284694","t":"Treatment of Neuropathic Pain Following Spinal Cord Injury - a RTMS Approach","d":"This study aims to determine if repetitive transcranial magnetic stimulation (rTMS) can improve pain symptomology in adults with neuropathic pain (NP) following a spinal cord injury (SCI).","s":"Unknown","tr":["Brain Stimulation"],"o":["Pain Management"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06284694","su":"https://scitrials.org/trial/NCT06284694"},{"n":"NCT05839652","t":"Treatment of Orthostatic Hypotension in SCI","d":"The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.","s":"Recruiting","tr":[],"o":["Blood Pressure"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05839652","su":"https://scitrials.org/trial/NCT05839652"},{"n":"NCT02006433","t":"Treatment of Pain and Autonomic Dysreflexia in Spinal Cord Injury With Deep Brain Stimulation","d":"The purpose of this research study is to determine if DBS is a feasible, safe and effective therapy for pain and autonomic dysreflexia after spinal cord injury.","s":"Completed","tr":["Brain Stimulation","Devices"],"o":["Blood Pressure","Pain Management"],"st":["Florida"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02006433"},{"n":"NCT02919917","t":"Treatment of Post-SCI Hypotension","d":"While treatment strategies for OH have been identified for use in persons with acute SCI, the field of SCI medicine lacks a gold standard for treatment thresholds and well-defined outcome parameters. Comprehensively documenting the impact of orthostatic hypotension (OH), regardless of symptoms, during acute rehabilitation and identifying the effects of two different treatment approaches on therapy participation and adherence to an intended rehabilitation plan could have a significant impact on…","s":"Completed","tr":["Drugs","Rehabilitation"],"o":["Blood Pressure","Quality of Life"],"st":["New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02919917"},{"n":"NCT02922894","t":"Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury","d":"This study will investigate potential therapeutic approaches for sleep-disordered breathing (SDB) in patients with chronic cervical spine injury (\\>6 months post-injury).","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02922894","su":"https://scitrials.org/trial/NCT02922894"},{"n":"NCT02830074","t":"Treatment of Sleep-disordered Breathing in Patients With SCI","d":"Sleep-disordered breathing (SDB) remains under-treated in individuals living with spinal cord injuries and disorders (SCI/D). The investigators' aim is to test a program that addresses challenges and barriers to positive airway pressure (PAP) treatment of SDB among patients with SCI/D. The investigators anticipate that patients who receive this program will have higher rates of PAP use and will demonstrate improvements in sleep quality, general functioning, respiratory functioning and quality…","s":"Completed","tr":[],"o":["Breathing Function","Quality of Life"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02830074"},{"n":"NCT04288934","t":"Treatment of Spinal Cord Injuries With (AutoBM-MSCs)vs (WJ-MSCs).","d":"This study aims to assess and compare the safety and effectiveness of Autologous Bone Marrow-Derived MSCs (AutoBM-MSCs) in one group(group A) of SCI who are unlikely to be able to walk independently without treatment after 1 year of SCI, in the other group (group B) to assess the second group of Wharton Jelly derived mesenchymal stem cells ( WJ-MSCs) in the treatment of acute and subacute spinal cord injury (SCI) patients.","s":"Completed","tr":["Stem Cells"],"o":[],"st":[],"co":["Jordan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04288934"},{"n":"NCT03612401","t":"Treatment of Spinal Cord Injury Patients for Neurogenic Bladder: Anticholinergic Agent vs. Mirabegron","d":"We propose to test the hypothesis that cognition will improve with substitution of mirabegron for the anticholinergic agent (AC) in elderly persons with spinal cord injury (SCI) who require neurogenic bladder (NGB) treatment.","s":"Completed","tr":["Drugs"],"o":["Bladder Function","Bowel Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03612401"},{"n":"NCT07253233","t":"Treatment of Spinal Cord Injury Using Autologous Concentrated Growth Factors","d":"Spinal cord injury (SCI) is a severe disorder of the central nervous system, and effective clinical management remains a significant global challenge. Current therapeutic approaches can only partially restore neurological function, leaving the majority of individuals with SCI facing profound and lifelong disabilities. The Department of Spine Surgery at the Third Affiliated Hospital of Sun Yat-sen University is conducting a clinical study on the use of autologous concentrated growth factors for…","s":"Not yet recruiting","tr":["Surgical Procedure"],"o":["Motor Function","Sensory Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07253233","su":"https://scitrials.org/trial/NCT07253233"},{"n":"NCT02427230","t":"Treatment of Urinary Incontinence in Women With Spinal Cord Injury","d":"The purpose of this study is to determine whether pelvic floor muscle training (PFMT) and intravaginal neuromuscular electrical stimulation (NMES) are effective in reducing urinary incontinence and improving quality of life in women with spinal cord injury (SCI).","s":"Completed","tr":["Drugs","Electrical Stimulation","Neuromuscular Electrical Stimulation (NMES)"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02427230"},{"n":"NCT05101018","t":"Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI","d":"The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of denosumab administration alone.","s":"Active, not recruiting","tr":[],"o":["Bone Strength"],"st":["New Jersey","New York"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05101018","su":"https://scitrials.org/trial/NCT05101018"},{"n":"NCT03521856","t":"Trial for Shoulder Pathology and Pain in Chronic SCI","d":"This research study will investigate in a 12-week home exercise program to see whether it is effective in improving shoulder pathology and reducing shoulder pain in persons with chronic spinal cord injury. The research study will involve ultrasound shoulder examinations of your shoulders using a non-invasive medical ultrasound machine, as well as clinical shoulder examinations and completion of a number of pain questionnaires.","s":"Completed","tr":[],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03521856"},{"n":"NCT02317640","t":"TRT in Combination With Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males","d":"The aim of this study is to understand what happens to muscle and bone in spinal cord injured males after four months of training using stand training, with body weight support (BWS), with testosterone replacement therapy (TRT), and electrical stimulation (ES). Specifically, researchers will investigate nerve, muscle, and bone changes in the lower limbs in response to stand training and ES when combined with TRT compared to i) standing alone with TRT; ii) stand training alone with placebo; iii)…","s":"Unknown","tr":["Rehabilitation"],"o":["Bone Strength"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02317640","su":"https://scitrials.org/trial/NCT02317640"},{"n":"NCT06612112","t":"Trunk Balance and Functional Independence in Individuals With SCI","d":"This study investigates the relationship between trunk balance, position sense, wheelchair skills, and functional independence in individuals with thoracic spinal cord injury. It aims to understand how these factors interact and influence daily activities and overall quality of life.","s":"Completed","tr":["Observational"],"o":["Quality of Life","Trunk Control"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06612112"},{"n":"NCT05196204","t":"Trunk Task-oriented Training Combined With Functional Electrical Stimulation in Spinal Cord Injured Individuals","d":"The objectives of the study are to evaluate trunk task-oriented training combined with function electrical stimulation (FES/T-TOT) efficacy on sitting balance and functional independence, and to understand the mechanisms of neuroplasticity that would improve functional independence following FES/T-TOT in individuals with spinal cord injury.","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":2,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05196204","su":"https://scitrials.org/trial/NCT05196204"},{"n":"NCT04056988","t":"tSCI Contrast Enhanced Ultrasound Study","d":"Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypo-perfusion of the spinal cord and exacerbates the severity of the injury. This is also referred to as secondary injury. Thus…","s":"Completed","tr":["Drugs","Surgical Procedure"],"o":["Blood Pressure"],"st":["Washington"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04056988"},{"n":"NCT07432321","t":"tSCS + UL Robotics Training in SCI Patients","d":"This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries. It also evaluates the impact of the tSCS+ULRT on health-related quality of life (HRQOL), compared to ULRT alone. This is a prospective single-arm crossover study in participants with incomplete chronic traumatic spinal cord injury. 6 to 8 subjects with C2-8 level injuries will be…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Singapore"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07432321","su":"https://scitrials.org/trial/NCT07432321"},{"n":"NCT05305118","t":"TSCS for Acute SCI","d":"This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too high (autonomic dysreflexia). Unstable BP often interferes with performing effective physical rehabilitation after SCI. A critical need exists for the identification of safe, practical and effective treatment options that stabilize BP after traumatic SCI…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Blood Pressure"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05305118","su":"https://scitrials.org/trial/NCT05305118"},{"n":"NCT06886386","t":"TsDCS and Physical Therapy After Incomplete Spinal Cord Injury","d":"The aim of this study is to evaluate the effects of tsDCS combined with physical therapy on the recovery of motor function in adult patients with chronic incomplete spinal cord injury.","s":"Enrolling by invitation","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":[],"co":["Brazil"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06886386","su":"https://scitrials.org/trial/NCT06886386"},{"n":"NCT07785258","t":"TTNS in SCI Patients With Neurogenic Detrusor Overactivity","d":"This is a prospective, single-arm, pilot study to assess effectiveness and tolerability of transcutaneous tibial nerve stimulation (TTNS) in managing neurogenic detrusor overactivity in spinal cord injury patients. 12 - 16 spinal cord injury patients with neurogenic detrusor overactivity will be recruited. The intervention includes administration of TTNS at the highest tolerated level for 20 minutes daily for 4 weeks, using a neuromodulation device -- Tensi+. Outcome measures including…","s":"Not yet recruiting","tr":["Devices","Electrical Stimulation","Transcutaneous Stimulation"],"o":["Bladder Function"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07785258"},{"n":"NCT07368244","t":"Turkish Translation and Content Validity of the Nottwil Environmental Factors Inventory (NEFI) in Persons With Spinal Cord Injury","d":"This observational methodology study will produce a Turkish version of the Nottwil Environmental Factors Inventory (NEFI-TR) within one month using a standardized translation and cultural adaptation process. Content validity will be assessed using an expert panel (and, if applicable, cognitive debriefing with adults with spinal cord injury) to ensure relevance, clarity, and comprehensibility of each item in the Turkish context.","s":"Recruiting","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07368244"},{"n":"NCT03964077","t":"Turkish Version of the Neurogenic Bladder Symptom Score Questionnaire: a Cross-cultural Adaptation, Reliability and Validity Study","d":"Turkish version of the Neurogenic Bladder Symptom Score questionnaire: a cross-cultural adaptation, reliability and validity study","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03964077"},{"n":"NCT07507331","t":"Turkish Version of the Neurogenic Bladder Symptom Score Short Form","d":"This observational study aims to evaluate the cross-cultural adaptation and psychometric properties of the Turkish version of the Neurogenic Bladder Symptom Score Short Form (NBSS-SF) in adults with spinal cord injury or multiple sclerosis who have neurogenic lower urinary tract dysfunction. Neurogenic bladder symptoms, such as urinary incontinence, urgency, and difficulties with urine storage or emptying, may negatively affect daily functioning and quality of life. In this study, the validity…","s":"Completed","tr":["Observational"],"o":["Bladder Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07507331"},{"n":"NCT00662207","t":"Two Devices for Reflex Voiding Following Spinal Cord Injury","d":"The purpose of this investigation is to evaluate methods in spinal cord injured individuals to improve reflex urination. Anal dilation will be investigated to reduce high urethral resistance and a vibrator on the patient's bottom will be tested to induce more sustained bladder contractions for better bladder emptying.","s":"Completed","tr":["Devices"],"o":["Bladder Function"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00662207"},{"n":"NCT06992596","t":"UAE-PRIME: A Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices","d":"The UAE-PRIME Study is a feasibility study designed to assess the initial clinical safety and functionality of the Neuralink N1 Implant and R1 Robot. This study involves participants who have tetraparesis, tetraplegia, or a diagnosis that may lead to these conditions. The N1 Implant is a wireless, rechargeable device mounted on the skull, connected to electrode threads that are inserted into the brain by the R1 Robot, which is a robotic device specifically designed for this procedure.","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":[],"co":["United Arab Emirates"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06992596","su":"https://scitrials.org/trial/NCT06992596"},{"n":"NCT06618404","t":"UK Prevalence of Mental Health After SCI","d":"Mental health decline after Spinal Cord Injury (SCI) is commonly reported but minimally investigated in the United Kingdom. The current study aims to explore the prevalence and impact of mental health challenges after SCI to establish population norms in the UK. Additionally the current study will aim to identify barriers to and facilitators of mental health support seeking in people with SCI.","s":"Completed","tr":["Observational"],"o":["Mental Health","Pain Management","Quality of Life"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06618404"},{"n":"NCT01851499","t":"Ultramicronized PEA (Normast) in Spinal Cord Injury Neuropathic Pain","d":"Randomized, double-blinded, placebo-controlled, parallel group study of ultramicronized PEA (Normast)600 mg x 2 daily or corresponding placebo with a week of baseline period followed by 1 x 12 weeks treatment period.","s":"Completed","tr":["Drugs"],"o":["Mental Health","Pain Management","Quality of Life","Spasticity"],"st":[],"co":["Denmark"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01851499"},{"n":"NCT07293949","t":"Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury","d":"Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression. This study aims to compare the talar cartilage thicknesses of spinal cord injury patients with healthy subjects. The secondary aim is to investigate a correlation between the talar cartilage thickness and disease-related parameters. The patient group is to be assessed for talar cartilage thickness (via…","s":"Completed","tr":[],"o":["Bone Strength"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07293949","su":"https://scitrials.org/trial/NCT07293949"},{"n":"NCT03468439","t":"Ultrasound and Peripheral Nerve Stimulator Guided Femoral Nerve Block","d":"A pre-post descriptive study was performed to examine the immediate effects of ultrasound (US) guided femoral nerve block with phenol (UGFNBwP) in managing lower limb spasticity of individuals with traumatic spinal cord injury (SCI).","s":"Completed","tr":[],"o":["Leg Movement","Quality of Life","Spasticity"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03468439"},{"n":"NCT05249595","t":"Ultrasound Imaging Based Sensing of Human Ankle Motion Intent and Control Strategies for Ankle Assistance","d":"Robotic therapies aim to improve limb function in individuals with neurological injury. Modulation of robotic assistance in many of these therapies is achieved by measuring the extant volitional strength of limb muscles. However, current sensing techniques, such as electromyography, are often unable to correctly measure the voluntary strength of a targeted muscle. The difficulty is due to their inability to remove ambiguity caused by interference from activities of neighboring muscles. These…","s":"Unknown","tr":["Electrical Stimulation","Exoskeleton","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Motor Function","Walking Function"],"st":["North Carolina"],"co":["United States"],"lc":2,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05249595"},{"n":"NCT04136743","t":"Ultrasound-Guided Treatments for Shoulder Pain in Wheelchair Users With Spinal Cord Injury","d":"Rotator cuff disease (i.e., rotator cuff tendinopathy or tear) is a common cause of shoulder pain in persons with chronic spinal cord injury (SCI). It usually resolves with non-operative treatments such as pharmacological agents and physical therapy; however, when this fails, rotator cuff surgery may be the only option. Corticosteroid injections are another alternative to provide temporary relief, but can over time accelerate degeneration of the tendon and lead to further damage. Autologous…","s":"Unknown","tr":[],"o":["Pain Management"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04136743","su":"https://scitrials.org/trial/NCT04136743"},{"n":"NCT01500174","t":"Ultraviolet-C Effectiveness in the Management of Pressure Ulcers in People With Spinal Cord Injury","d":"The objective of the study is to examine the effectiveness of Ultraviolet-C (UVC) for healing pressure ulcers in people with spinal cord injury. UVC is a form of radiation similar to sunlight but it is normally absorbed in the earth's atmosphere. Participants will be assigned by chance to receive placebo-UVC or real UVC treatment, in addition to receiving wound care according to best practice guidelines. The hypothesis is that UVC-treated wounds will heal at a faster rate than wounds receiving…","s":"Completed","tr":["Devices"],"o":["Pressure Sores","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01500174"},{"n":"NCT03979742","t":"Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training","d":"Umbilical cord blood mononuclear stem cells (UCBMSCs) transplant followed by the intensive locomotor training for up to 5±1 hours a day, 5±1 days a week, and for 3-6 months for treatment in patients with chronic, stable and complete spinal cord injury.","s":"Terminated","tr":["Rehabilitation"],"o":["Quality of Life","Walking Function"],"st":[],"co":["Taiwan"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03979742"},{"n":"NCT01354483","t":"Umbilical Cord Blood Mononuclear Cell Transplant to Treat Chronic Spinal Cord Injury","d":"The purpose of this study is to investigate the feasibility, safety, efficacy and optimal dose of umbilical cord blood mononuclear cell transplant in the treatment of chronic spinal cord injuries.","s":"Completed","tr":["Drugs","Stem Cells"],"o":["Motor Function","Pain Management","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["China"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01354483"},{"n":"NCT07738978","t":"Understanding and Enhancing Human Health and Movement","d":"By doing this study, investigators hope to learn how electrical stimulation can improve human movement, biomechanics, and function and to gather information on the safety and effectiveness of an implanted electrical stimulation system after paralysis from spinal cord injury, stroke, multiple sclerosis, and traumatic brain injury.","s":"Recruiting","tr":["Electrical Stimulation"],"o":["Walking Function"],"st":["Ohio"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07738978"},{"n":"NCT07796035","t":"Understanding Communication Barriers in Acute Care: A Mixed-Methods Needs Assessment Among Healthcare Providers Caring for Non-Verbal Patients With Spinal Cord Injury and Tracheostomy in the ICU","d":"Communication impairment is common among critically ill patients who are mechanically ventilated, have tracheostomies, or have neurological injuries such as spinal cord injury. In acute care settings, inability to communicate contributes to patient distress, impairs symptom assessment, and may delay care. Although a range of communication supports exist, many are difficult to use in patients with severe weakness, limited endurance, or fluctuating cognition. More advanced assistive communication…","s":"Not yet recruiting","tr":["Brain Machine Interface (BMI)","Observational"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07796035"},{"n":"NCT04000256","t":"Understanding Experiences of People With Spinal Cord Injury Undergoing Activity-based Rehabilitation","d":"Incomplete cervical spinal cord injury (SCI) makes up half of all the newly admitted patients. For these individuals, the use of their upper limbs is critical for managing daily activities and self-care and impacts their quality of life. For home-based monitored rehabilitation, also called telerehabilitation, there are various rehabilitation equipment that are used. No studies have systematically gathered information regarding the perceptions of individuals with SCI regarding these equipment…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["California","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04000256","su":"https://scitrials.org/trial/NCT04000256"},{"n":"NCT06808035","t":"Understanding Perinatal Spinal Cord Injury","d":"The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination with transcutaneous spinal cord stimulation (scTS). This is a within subjects, pre-post design study. Neurophysiological, sensorimotor, and autonomic assessments will occur pre, interim, and post 40 sessions of ABRT in conjunction with scTs.","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":[],"st":["Kentucky"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06808035","su":"https://scitrials.org/trial/NCT06808035"},{"n":"NCT01236170","t":"Understanding Quality and Equity in Wheelchairs for Veterans","d":"The Department of Veterans Affairs (VA) provides wheelchairs to about 42,000 Veterans with SCI and more than 40,000 Veterans with amputated limbs (AL). Despite VA's efforts to remove financial and other barriers to the provision of wheelchairs to all Veterans who need them, preliminary evidence suggests that disparities exist in the quality of wheelchairs prescribed to racial minorities and low income Veterans with SCI or AL. The proposed project will provide important information to the VA…","s":"Completed","tr":["Observational"],"o":["Quality of Life"],"st":["Florida","New York","Ohio","Pennsylvania","Virginia"],"co":["United States"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01236170"},{"n":"NCT02926391","t":"UNiD 3D VBR Register","d":"Multicenter study allowing to include the first sixty patients implanted with a custom-made corpectomy implant (UNiD 3D VBR): 30 patient implanted in cervical region and 30 patients implanted in thoracolumbar region. The main objective is to confirm feasibilty and safety of patient-specific implants for one or multi-level corpectomy and fusion. This study was approved in March 2016 allowing to include retrospectivley all patients since the first implantation in January 2015 and prospectively…","s":"Completed","tr":["Devices","Observational","Surgical Procedure"],"o":["Pain Management","Quality of Life"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02926391"},{"n":"NCT05687097","t":"Untreated Sleep Apnea as an Aggravating Factor for Other Secondary Medical Conditions After Spinal Cord Injury","d":"This cross-sectional prospective study will assess the potential association of more severe sleep apnea after spinal cord injury with more intense neuropathic pain, more severe spasticity, and more significant cardiovascular abnormalities including cardiac arrhythmias and blood pressure fluctuations. In addition, the participants' experience when undergoing home-based sleep screening test or hospital-unattended sleep screening test will be assessed in a semi-structured interview.","s":"Completed","tr":["Devices","Observational"],"o":["Blood Pressure","Pain Management","Spasticity"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05687097"},{"n":"NCT04163796","t":"UPnRIDE Power Standing Wheelchair for SCI","d":"People with higher level of spinal cord injury have limitations to using exoskeletal-assisted walking devices due to restrictions of trunk stability, functional use of the upper extremities and hand grip. With increasing sedentary time in wheelchairs, people with SCI have a high risk for developing secondary complications. A powered wheelchair has recently been developed for use in persons with spinal cord injury that provides a solution for placing the user in an upright, standing position…","s":"Completed","tr":["Devices"],"o":["Blood Pressure","Bowel Function","Breathing Function","Hand Movement","Leg Movement","Quality of Life","Trunk Control","Walking Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04163796"},{"n":"NCT02983955","t":"UPNRIDE Powered Wheelchair for Individuals With Walking Impairment: Evaluation of Safety and Usability","d":"The UPnRIDE Powered Wheelchair device is a product which changes people position from sitting to standing and standing to sitting. The product provides indoor and outdoor mobility. The main purpose of this study is to evaluate the safety of the UPnRIDE powered wheelchair as an outdoor and indoor mobility device by individuals with walking impairment.","s":"Unknown","tr":["Devices"],"o":["Quality of Life"],"st":[],"co":["Israel"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02983955","su":"https://scitrials.org/trial/NCT02983955"},{"n":"NCT06672458","t":"Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)","d":"The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work. The study team wants to understand what recovery looks like in persons with a spinal cord injury (SCI) or peripheral nerve injury (PNI) using the MyndMove (MyndTec Inc., Ontario, Canada) therapy system. This type of therapy uses stimulation to help people with SCI and other neurological conditions to perform common tasks, work out, or…","s":"Recruiting","tr":[],"o":["Arm Movement","Hand Movement"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06672458","su":"https://scitrials.org/trial/NCT06672458"},{"n":"NCT06278740","t":"Upper Extremity Pathologies in Spinal Cord Injuries","d":"This study aims to determine the relationship between upper extremity pathologies and demographic data, duration of manual wheelchair use, duration of injury, physical examination and musculoskeletal ultrasound measurements in patients with spinal cord injuries.","s":"Completed","tr":["Observational"],"o":["Arm Movement","Pain Management","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06278740"},{"n":"NCT01899664","t":"Upper Extremity Surgery in Spinal Cord Injury","d":"The goal of the investigators work is to establish how nerve transfers can be best used to improve upper extremity function in patients with cervical level spinal cord injury (SCI). The investigators' hypothesis is that nerve transfers are safe and effective and will improve function and quality of life in patients with loss of upper function due to spinal cord injury. The investigators plan on looking at upper limb function, and health-related quality of life in patients before and after…","s":"Completed","tr":["Surgical Procedure"],"o":["Arm Movement","Hand Movement","Quality of Life"],"st":["Missouri"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01899664"},{"n":"NCT04921592","t":"Upper Extremity Training for Chronic Cervical Spinal Cord Injury","d":"This study is to understand how the combination of activity-based recovery training and targeted spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hand, arms, and core.","s":"Recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04921592","su":"https://scitrials.org/trial/NCT04921592"},{"n":"NCT02098122","t":"Upper Limb Activity in Human SCI Rehabilitation","d":"Functional recovery following SCI in adults is limited. Improvements in the quality of life of affected persons are associated with the recovery of functions that allow independent living, for example use of the arms and hands. Rehabilitative training has been shown to aid upper limb recovery. However, there are likely vast differences in the amount of time individuals spend actively training (during rehabilitation sessions in the clinic) and what they do in their non-training time (during…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Arm Movement","Quality of Life"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02098122"},{"n":"NCT04358679","t":"Upper Limb Ergometer on Pulmonary Function Among Patients With Spinal Cord Injury.","d":"Randomized Control Trial, To determine the effects of arm ergometer exercise on pulmonary function of Spinal Cord Injury.","s":"Completed","tr":[],"o":["Arm Movement","Breathing Function"],"st":[],"co":["Pakistan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04358679"},{"n":"NCT06608121","t":"Upper Limb Muscle Strength Models for Patients With Motor Impairment.","d":"Upper limb motor impairments are common. They affect quality of life and can lead to dependency. They are mainly due to neurological conditions such as stroke, multiple sclerosis, and traumatic spinal cord injury. However, the contractile properties of muscle, in particular the maximum force that can be generated voluntarily (MVF) depending on joint angle and motion speed, have been mainly studied and modeled in healthy people. This study aims at developing mathematical models describing…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Motor Function","Quality of Life"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06608121"},{"n":"NCT06782464","t":"Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment","d":"This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: \"Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add value in dealing with shoulder pain and functional problems caused by spasticity and motor impairment\". It is a non-inferiority study on the referred topic, comparing the therapeutic effect (improvement in function and pain) of cryoneurolysis of selected nerves (lateral…","s":"Recruiting","tr":["Drugs","Electrical Stimulation","Rehabilitation"],"o":["Arm Movement","Pain Management","Quality of Life","Sensory Function","Spasticity"],"st":[],"co":["Luxembourg"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06782464"},{"n":"NCT07361627","t":"Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation","d":"The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury (SCI). As secondary aims, the study will also investigate at how this combination approach affects the cortical changes in the somatosensory and motor areas of the brain, as well as in the spinal cord and whether it helps participants use their arms more in daily life. The…","s":"Not yet recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07361627","su":"https://scitrials.org/trial/NCT07361627"},{"n":"NCT05991804","t":"Upper Limb Spinal Cord Stimulation for Rehabilitation Enhancement","d":"In the United Kingdom, there are more than 1000 new cases of spinal cord injury (SCI) each year, with around half of these injuries affecting the cervical spine. People who have reduced function and control affecting their upper limbs may have difficulty carrying out activities of daily living (ADLs), significantly affecting their independence. Recovering even partial upper limb function is a top priority among tetraplegics. Regaining voluntary function in the upper limb can have a huge impact…","s":"Recruiting","tr":["Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05991804","su":"https://scitrials.org/trial/NCT05991804"},{"n":"NCT05568862","t":"Ureteric Jet Doppler Waveforms in Patients With Spinal Cord Injury","d":"Urinary dysfunction is very common in individuals with spinal cord injury. The urine flowing from the collecting ducts to the renal calyx stretches the calyces. ANS controlled peristaltic contractions originate in the proximal renal pelvis and travel down the ureters, pushing urine from the renal pelvis towards the bladder. The urine bolus delivered from the kidneys through the peristaltic contraction of the ureter creates an image called ureteric jet. Using the Doppler analysis of ureteral…","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05568862"},{"n":"NCT02852317","t":"Urinary Markers of Detrusor Overactivity in Spina Bifida Patients","d":"The purpose of this study is to assess diagnostic performance of urinary markers of detrusor overactivity (Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF), adenosine triphosphate (ATP), Prostaglandine E2) in detected high pressure bladder un spina bifida patients.","s":"Completed","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02852317"},{"n":"NCT06892080","t":"Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury/Disease - a Pilot Study","d":"There is a knowledge gap about the influence of the menstrual cycle on bladder function in women with spinal cord injury. So far, studies regarding urinary incontinence have primarily focused on women after menopause. It has become clear that a lack of the sex hormone estrogen, which occurs after menopause, can lead to urinary incontinence. During the course of the menstrual cycle, women also experience fluctuations in their sex hormones, particularly estrogen. The estrogen level is highest…","s":"Recruiting","tr":[],"o":["Bladder Function","Sexual Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06892080","su":"https://scitrials.org/trial/NCT06892080"},{"n":"NCT02044510","t":"Urodynamic and Clinical Efficacy of Mirabegron for Neurogenic Bladder Patients","d":"The proposed study is a randomized, double blind placebo controlled multicenter study to determine the effectiveness of mirabegron in the treatment of neurogenic bladder dysfunction. Patients will be randomized into one of two trial arms: mirabegron 25mg for two weeks, with escalation to 50mg for the remaining 8 weeks, or matched placebo capsule for two weeks, with placebo escalation for the remaining 8 weeks. Each of these trial arms will be stratified based on whether the patient is already…","s":"Terminated","tr":["Drugs"],"o":["Bladder Function","Quality of Life","Sensory Function"],"st":[],"co":["Canada"],"lc":5,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02044510"},{"n":"NCT04231474","t":"Urodynamic Evaluation in Patients After Spinal Cord Injury","d":"Retrospective study, which analyzed 100 medical histories of patients who were admitted o the Neurological Rehabilitation Ward of the Rehabilitation Clinic in the Orthopedic-Rehabilitation Hospital in Poznan in years 2010-2019.","s":"Unknown","tr":["Observational"],"o":["Bladder Function"],"st":[],"co":["Poland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT04231474","su":"https://scitrials.org/trial/NCT04231474"},{"n":"NCT04642170","t":"Urodynamics of Suprasacral Spinal Cord Injury Patients","d":"The medical records of 215 patients with spinal cord injury(SCI) at the Department of Rehabilitation Medicine of the 2nd Affiliated Hospital of Wenzhou Medical University, Wenzhou, China were evaluated between January 1, 2016 and December 20, 2019. According to the inclusion criteria and exclusion criteria, 101 patients were included. The patients were dichotomized into two groups: complete SCI group and incomplete SCI group, based on the American Spinal Injury Association Guidelines Impairment…","s":"Completed","tr":["Observational","Rehabilitation"],"o":["Bladder Function","Sensory Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04642170"},{"n":"NCT04483570","t":"Urological Deterioration in Secondary Tethered Cord Syndrome and Clue to Detect It","d":"Secondary tethered cord syndrome (STCS) has been diagnosed with signs of progressive deterioration in urological or neuroorthopedic systems following primary tethering surgery. However, there is no convincing urological diagnostic clue for STCS.","s":"Completed","tr":["Observational","Surgical Procedure"],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04483570"},{"n":"NCT05959837","t":"Usability of the Adapted Rower for People With Spinal Cord Injury","d":"The goal of this clinical trial is to examine usability of a locally built adaptive rower for people with spinal cord injury using an established and tested design. The main questions it aims to answer are: 1. What exercise intensity of activity do users achieve on the rower for steady state and interval rowing plans? 2. What assistance is required for setup and usage of the adaptive rower? 3. What do users think about the ease of use and what is their satisfaction with the adaptive rower?…","s":"Unknown","tr":["Rehabilitation"],"o":[],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05959837","su":"https://scitrials.org/trial/NCT05959837"},{"n":"NCT00333762","t":"Use of \"Smart Wheelchairs\" to Provide Independent Mobility to Visual and Mobility Impairments","d":"The goal of this project is to evaluate the Smart Wheelchair Component System (SWCS) for power wheelchairs and the Smart Power Assistance Module (SPAM) for manual wheelchairs in realistic indoor environments with target users performing realistic tasks. We will combine group trials involving individuals who have a visual impairment (but do not have a mobility impairment) with several single-case studio involving individuals who have a visual and mobility impairment. Our long-term objective is…","s":"Completed","tr":["Devices"],"o":[],"st":["Georgia","Pennsylvania"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00333762"},{"n":"NCT03573726","t":"Use of a Diurnal Indwelling Urethral Catheter to Improve Quality of Life","d":"This is an interventional study examining the effects of closed diurnal indwelling catheterization (CDIC) for neurogenic bladder management.","s":"Completed","tr":["Devices"],"o":["Bladder Function","Quality of Life"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03573726"},{"n":"NCT04671030","t":"Use of a Prokinetic Agent as an Adjunct to Thrice Weekly Bowel Care After SCI","d":"To measure a baseline for each subject, an abdominal x-ray (KUB) was performed, the SCI Bowel Survey and Treatment Satisfaction Questionnaire (TSQM) were administered and the subject's weight determined. After all the baseline measurements were acquired, the subjects underwent transdermal screening with hair epilation to test their response to transdermal administration of NEO (0.07mg/kg) and GLY (0.014mg/kg). All subjects had a positive response (bowel movement within 60 minutes of drug…","s":"Completed","tr":["Devices","Drugs"],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04671030"},{"n":"NCT03220451","t":"Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients","d":"All patients with a significant deficiency of skin sensitivity and reduced mobility are potentially at risk of Pressure Ulcers (PUs), in particular the persons affected by Spinal Cord Injury (SCI), also due to their frequent alteration or loss of subcutaneous skin sensitivity. Pressure sores are one of the most common and fearful complications in SCI, with a severe impact on quality of life and on care health costs. They are often the cause of lengthening the time of hospitalization, slowing…","s":"Completed","tr":["Rehabilitation","Surgical Procedure"],"o":["Pain Management","Pressure Sores","Quality of Life","Spasticity"],"st":[],"co":["Italy"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03220451"},{"n":"NCT00755079","t":"Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury","d":"The primary purpose of this study is to determine the effect of administration of the oral beta-2 adrenergic agonist, albuterol, on respiratory muscle strength in individuals with cervical (neck) and high thoracic (upper back) spinal cord injury and to compare findings with those obtained in a demographically matched group that will receive placebo. Participation in this study will involve 12 weeks of pharmacological intervention during which participants will be randomized to receive either…","s":"Completed","tr":["Drugs"],"o":["Breathing Function","Motor Function","Quality of Life"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00755079"},{"n":"NCT00781833","t":"Use of Implanted Microstimulators for Decreasing Spasticity and Improving Motion Following Spinal Cord Injury","d":"The primary aims of this study are to determine the safety of the RFM System (Alfred Mann Foundation, Santa Clarita, CA) in a patient with incomplete SCI and the effect of the RFM system on lower limb strength and spasticity. The secondary aim is to analyze any improvement in the participant's mobility.","s":"Terminated","tr":["Devices"],"o":["Leg Movement","Motor Function","Spasticity"],"st":["District of Columbia"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00781833"},{"n":"NCT01537978","t":"Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury","d":"The purpose of this study is to evaluate whether there are functional improvements in arm muscles and movments for spinal cord injured indviduals after performing video gaming.","s":"Completed","tr":[],"o":[],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01537978"},{"n":"NCT04303728","t":"Use of Muscle Ultrasound to Predict Function","d":"Establish if change from the baseline in ultrasound muscle parameters over 2 months of rehabilitation correlates with functional status of SCI patients at the end of rehabilitation","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Quality of Life","Spasticity","Walking Function"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04303728"},{"n":"NCT03721861","t":"Use of Neural Functional Electrical Stimulation for the Recovery of Grasping Movements for Patient With Quadriplegia.","d":"Functional electrical stimulation (FES) has been used for decades in rehabilitation centers. Having demonstrated efficacy for prevention of muscle atrophy following spinal cord injury (SCI), FES can also be considered for functional restoration of hand movements in the patients with complete tetraplegia belonging to group 0 or 1 of the classification of Giens. However, the majority of the systems using the FES directly stimulates the muscles (surface electrodes, intramuscular or epimysial)…","s":"Terminated","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Rehabilitation"],"o":[],"st":[],"co":["France"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03721861"},{"n":"NCT02355938","t":"Use Of Oral Fidaxomicin Vs. Oral Vancomycin For Clostridium Difficile Infection In Patients With Spinal Cord Injury","d":"The primary purpose of this study is to compare the clinical outcomes of cure and recurrence of Clostridium difficile infection in spinal cord injured patients who are treated with oral Fidaxomicin vs. oral Vancomycin. The secondary aim of this study is to compare the overall costs of treatment of Clostridium difficile infection in the two study groups.","s":"Terminated","tr":["Drugs"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02355938"},{"n":"NCT06333886","t":"Use of Point-of-care Neuro-sacral Electrophysiology Following Spinal Cord Injury","d":"Assessing the sacral nerves is an integral aspect of the evaluation after a spinal cord injury. Being located at the lower end of the spinal cord, the sacral nerves reflect how signals travel through the injured spinal cord. Sacral assessment is therefore essential to determine the level and severity of the spinal cord injury, which helps selecting the proper treatment and predicting recovery (worse when abnormal sacral function. The current assessment relies solely on a manual evaluation…","s":"Active, not recruiting","tr":["Electrical Stimulation","Observational"],"o":["Bladder Function","Bowel Function","Sensory Function"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06333886","su":"https://scitrials.org/trial/NCT06333886"},{"n":"NCT02370433","t":"Use of Prokinetics During Inpatient Bowel Care for SCI Patients","d":"Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals report BC routines lasting for more than 1 hour. In past studies, the investigators have shown that a medication called neostigmine can increase bowel activity and thus, promote bowel movement. The investigators have successfully used this medication with traditional and…","s":"Unknown","tr":[],"o":["Bowel Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT02370433","su":"https://scitrials.org/trial/NCT02370433"},{"n":"NCT00458354","t":"Use of Spinal Sealant System During Spinal Surgery","d":"1. To evaluate the safety and efficacy of the Spinal Sealant as an adjunct to sutured dural repair compared with standard of care methods (control) to obtain watertight dural closure intraoperatively in patients undergoing spinal surgery. 2. To evaluate the safety and efficacy of the Spinal Sealant as an adjunct to sutured dural repair compared with standard of care methods (control) to obtain watertight dural closure in patients undergoing spinal surgery up to 90 days post-procedure.","s":"Completed","tr":["Devices","Surgical Procedure"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00458354"},{"n":"NCT05122949","t":"User Satisfaction of Customised 3D Printed Ankle-Foot Orthosis in Comparison to Thermoformed Ankle-Foot Orthosis for Patients With Neurological Conditions: A Preliminary Study","d":"Study Design and Subject Recruitment: This was a cross-sectional study in a single centre outpatient setting at the Foot Care and Limb Design Centre, Tan Tock Seng Hospital. As this was a proof-of-concept clinical trial for the introduction of 3D printed AFOs as a patient service, only 5 subjects were recruited based on consecutive sampling. Interventions: Thermoformed AFOs moulded over the subject's lower limb plaster model served as the control intervention. The plaster models were rectified…","s":"Completed","tr":["Devices"],"o":["Leg Movement","Walking Function"],"st":[],"co":["Singapore"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05122949"},{"n":"NCT07073313","t":"Using Muscle Functional MRI to Study Spatial Muscle Activation Patterns in People With SCI","d":"Several types of treatment and therapy have been shown to promote improvements in movement and other health gains in people with spinal cord injury (SCI). Researchers use many different methods to measure these gains- for instance they measure their ability to stand and walk and use scanning technologies to measure bone loss and recovery. They also often use a technique known as electromyography (EMG), which detects electrical signals coming from muscles, to measure how well the muscles are…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07073313","su":"https://scitrials.org/trial/NCT07073313"},{"n":"NCT04097015","t":"Using NI-ES to Treat Spinal Cord Injury (SCI)","d":"NI-ES therapy is a treatment that is being studied to potentially treat pain associated with SCI and may help movement below the injury site.","s":"Unknown","tr":["Devices"],"o":["Motor Function","Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04097015"},{"n":"NCT07423949","t":"Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury","d":"Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with tetraplegia. Although rehabilitation and emerging neuromodulation approaches can support meaningful gains, many individuals experience persistent limitations in reaching and grasping. Current noninvasive stimulation strategies typically target the brain OR the spinal cord…","s":"Not yet recruiting","tr":["Brain Stimulation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07423949","su":"https://scitrials.org/trial/NCT07423949"},{"n":"NCT05317832","t":"Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury","d":"The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities. A primary objective of this study is to evaluate the integration of a JITAI with a web-based physical activity intervention program. We hypothesize that the integration of web-based physical activity intervention program with JITAI will result in…","s":"Recruiting","tr":["Rehabilitation"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05317832","su":"https://scitrials.org/trial/NCT05317832"},{"n":"NCT02406859","t":"Utility of an Animated Bowel Biofeedback Training Routine to Improve Bowel Function in Individuals With SCI","d":"An injury to the spinal cord results in a number of secondary medical problems, including the inability to voluntarily control the bowels. Depending on the severity and location of the injury, remaining bowel function differs, and can include any combination of the following: constipation (prolonged stool retention), difficulty with evacuation (difficultly moving bowels), fecal incontinence (problems retaining stool until it is appropriate to move the bowels). Most of the current medications…","s":"Completed","tr":[],"o":["Bladder Function","Bowel Function","Motor Function","Sensory Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02406859"},{"n":"NCT06010251","t":"Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain","d":"The purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tDCS) on neuropathic pain symptoms and sensory functions in participants with spinal cord injury (SCI) and neuropathic pain.","s":"Recruiting","tr":["Brain Stimulation"],"o":["Pain Management"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06010251","su":"https://scitrials.org/trial/NCT06010251"},{"n":"NCT06924177","t":"UTSW NORC Pilot Spinal Cord Injury Dietary Program","d":"The goal of this observational study is to learn about the effects of a 9-week dietician-guided program modified from the National Diabetic Prevention Program (modified DPP-diet) in people with spinal cord injury on body composition and insulin sensitivity. The main question it aims to answer is: Does 9 week modified DPP-diet reduce body fat percentage and insulin resistance? Participants will: Have 9 weeks of Telehealth visit with dietician certified in providing DPP. Visit the laboratory…","s":"Recruiting","tr":["Nutrition"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06924177","su":"https://scitrials.org/trial/NCT06924177"},{"n":"NCT02983266","t":"Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia","d":"The purpose of this research device study is to learn more about the autonomic nervous system. This system uses nerves to send information from the brain to the rest of the body by electrical signaling and has two divisions, the sympathetic and the parasympathetic branches. It has been thought that electrical stimulation devices could be used to restore balance to the nervous system. Because most of the imbalance seems to happen due to too much sympathetic activity, the investigator plans to…","s":"Withdrawn","tr":["Devices","Electrical Stimulation"],"o":["Blood Pressure","Trunk Control"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02983266"},{"n":"NCT06351111","t":"Vagus Nerve Stimulation (VNS) in Spinal Cord Injury (SCI) Adaptive Follow-On Study","d":"This study is an open label extension of the SCI EFS clinical trial (NCT04288245) that developed an innovative strategy to enhance recovery of motor and sensory function after neurological injury. The objectives of this study are to provide continued safety assessment for the investigational ReStore system, and to gain further estimate of the effect of Vagus Nerve Stimulation (VNS) with rehabilitative exercises in four different tracks - upper limb (UL), lower limb (LL), bladder control (BC)…","s":"Enrolling by invitation","tr":["Electrical Stimulation"],"o":["Arm Movement","Bladder Function","Leg Movement"],"st":["Texas"],"co":["United States"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06351111","su":"https://scitrials.org/trial/NCT06351111"},{"n":"NCT02425332","t":"Validation of a Novel Robot-aided Assessment of Gait Ability","d":"The aim of this study is the validation of a novel gait assessment method implemented in the Lokomat gait trainer with respect to established clinical gait assessment methods. The walking assessment method is based on the progressive reduction of the support of the device. The outcome measures of this algorithm will be the support needed in the different gait phases (guidance force of hip and knee joints) and the support required to the body weight support system (unloading). The hypothesis is…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02425332"},{"n":"NCT01785277","t":"Validation of a Translation Into Spanish (Mexico) of the Spinal Cord Independence Measure III","d":"The propose of the study is to validate in Mexico a spanish translation of the Spinal Cord Independence Measure (SCIM) Version III, in patients with spinal cord injury (SCI). Internal consistency, reproducibility and reliability will be addressed scoring the results of the translated version at two time frames and also of the same patients by different examiners (physicians, nurses and technicians).","s":"Unknown","tr":["Observational"],"o":["Quality of Life"],"st":[],"co":["Mexico"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT01785277"},{"n":"NCT06950411","t":"Validation of AI Lumbar Spine Anatomy Measureing Function","d":"Spinal degeneration and its associated clinical diseases are common ailments in aging societies. With the advent of a super-aging society, the importance of assistive technologies for spinal image interpretation is increasingly significant to enhance care efficiency and reduce medical personnel expenditure. Recently, due to the rapid development of artificial intelligence (AI) algorithm, AI-based computer-assisted detection (CADe) devices gradiually become a convenient method for spinal anatomy…","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Taiwan"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06950411"},{"n":"NCT00623961","t":"Validation Study of Neuropathic Pain","d":"This study seeks to validate clinically evoked or obtained objective pain signs with the patient's corresponding quantified subjective pain symptoms. This will allow for validation of objective clinical pain signs to then be used to begin to classify patients with pain based on symptoms and signs. This then can be used as a basis for further study of neuropathic pain mechanisms in human patients.","s":"Completed","tr":["Observational"],"o":["Pain Management"],"st":["Wisconsin"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00623961"},{"n":"NCT06943040","t":"Validity and Reliability of 6-minute Pegboard and Ring Test","d":"Spinal Cord Injury (SCI) is a severe neurological condition that occurs as a result of traumatic or non-traumatic causes and results in motor, sensory, and/or autonomic dysfunction. The daily life of individuals with SCI often consists of low activity levels, which can cause loss of physical condition. Therefore, the participation of individuals with SCI in exercise is necessary to improve cardiovascular health and function, as well as to increase life expectancy and quality. Determining the…","s":"Completed","tr":["Observational"],"o":["Arm Movement","Blood Pressure","Motor Function","Quality of Life"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06943040"},{"n":"NCT04291924","t":"Validity and Reliability of a Low-cost Chair Dynamometer","d":"In part 1 of the study, fourteen able-bodied individuals will undergo maximal, voluntary contraction (MVC) test of the lower limbs in two dynamometers. One being a low-cost dynamometer (S2P-CD), and the other being a gold standard dynamometer (HUMAC). Thereby the investigators will be able to assess the validity of the S2P-CD. In part 2 of the study, eighteen persons with spinal cord injury will undergo MVC twice in the S2P-CD. Thereby the investigators will be able to assess the reliability of…","s":"Unknown","tr":["Observational"],"o":[],"st":[],"co":["Denmark"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04291924"},{"n":"NCT06657742","t":"Validity and Reliability of SCIM-SR","d":"To determine the validity and reliability of SCIM-SR, patients will fill out SCIM 3 and SR.","s":"Completed","tr":["Observational"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06657742"},{"n":"NCT06256159","t":"Validity and Reliability of the 12-item Multiple Sclerosis Walking Scale (12-WS) in Subjects With Spinal Cord Injury","d":"Established gait assessments for subjects with spinal cord injury (SCI) (6MWT, 10MWT, TUG, SCIM III and WISCI II) are widely used in the clinical and research setting. So far, no valid measurement exists that assesses the patients' perspective of walking ability in SCI. As there is the 12-item Multiple Sclerosis Walking Scale (12-WS) to assess the patients' perspective on gait ability in patients with multiple sclerosis, it is hypothesized that the 12-WS would also be a valid instrument for…","s":"Completed","tr":[],"o":["Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06256159"},{"n":"NCT04555759","t":"Validity and Reliability of the 2-minute Walk Test in Individuals With a Spinal Cord Injury","d":"There exist a variety of outcome measures to asses gait function in individuals with a spinal cord injury (SCI). The most established measures are the 10-meter walk test (10MWT) and the 6-minute walk test (6mWT). They are used to assess treatment efficacy and recovery of gait function in individuals with SCI. However, the 10MWT is appropriate for poor walkers but not sensitive in good walkers and the 6mWT can be time-consuming and is very demanding for severely impaired patients. Therefore the…","s":"Completed","tr":[],"o":["Walking Function"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04555759"},{"n":"NCT05182411","t":"Validity and Reliability of Turkish Version Leg Activity Measure","d":"Patient-filled scales minimize the burden of data collection for clinicians in a clinical setting. Therefore, Leg activity measure, a new self-report measure of active and passive function in the leg, has been developed. Leg activity measure consists of three parts. The first part includes passive functions, the second part includes active functions, and the third part includes the assessment of quality of life. It is a valid and reliable test in adult neurological patients with lower extremity…","s":"Completed","tr":["Observational"],"o":["Leg Movement","Quality of Life","Spasticity"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05182411"},{"n":"NCT04266964","t":"Validity and Reliability Study of the Muscle Excitability Scale in Spinal Cord Injury Patients","d":"The aim of the study is to verify validity and reliability of the Muscle excitability scale (MES), which has been developed to access muscle susceptibility to spasms and/or clones as part of spastic motor behavior in spinal cord injured patients.","s":"Completed","tr":["Observational"],"o":["Spasticity"],"st":[],"co":["Czechia"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04266964"},{"n":"NCT07448883","t":"Validity of the Turkish Translation of the Modified JOA","d":"Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment. Accurate and standardized assessment of neurological function is essential for clinical decision-making, prognostic evaluation, and comparison of treatment outcomes. The Modified Japanese Orthopaedic Association (mJOA) score is one of the most widely used clinician-based outcome measures for evaluating…","s":"Recruiting","tr":["Observational","Rehabilitation"],"o":[],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07448883"},{"n":"NCT07745686","t":"VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury","d":"The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce reliance on laboratory-based equipment during rehabilitation in participants with traumatic spinal cord injury. The TWIICE exoskeleton is integrated through the NR system, a platform developed by EPFL. The goal is to assess the clinical safety and practical application…","s":"Not yet recruiting","tr":["Brain Machine Interface (BMI)","Devices","Electrical Stimulation","Epidural Stimulation","Exoskeleton","Rehabilitation","Safety"],"o":["Motor Function","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07745686"},{"n":"NCT01555983","t":"Vaporized Cannabis and Spinal Cord Injury Pain","d":"This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury. To further evaluate potential benefits and side effects, the effect of different strengths of cannabis on mood, cognition, and psychomotor performance will also be measured.","s":"Completed","tr":["Drugs"],"o":["Mental Health","Pain Management"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01555983"},{"n":"NCT02865343","t":"Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury","d":"The investigators have an existing exercise program (N\\>70) with a unique population of individuals with spinal cord injury (SCI) who have been enrolled in FES-RT for at least 6 months. Roughly half have high level SCI. Thirty individuals with high level SCI who have FES-row trained for at least 6 months will be randomized to (continued) FES-RT for 3 months with either NIV or sham NIV. Before and after training, the investigators will assess maximal aerobic capacity, ventilation, cardiac…","s":"Completed","tr":["Functional Electrical Stimulation (FES)","Rehabilitation"],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02865343"},{"n":"NCT00333580","t":"Veteran-Centered Outcomes Using Qualitative and Quantitative Methods","d":"The purpose of this study is to modify and develop measures that reflect outcomes that are relevant to recovering Veterans and are sensitive to improvements resulting from innovative gait interventions.","s":"Completed","tr":["Observational"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00333580"},{"n":"NCT07213986","t":"Vibrant Capsule for Spinal Cord Injury Neurogenic Bowel Dysfunction","d":"The goal of this study is to test the safety and effectiveness of Vibrant capsules in spinal cord injury patients with neurogenic bowel.","s":"Recruiting","tr":[],"o":["Bowel Function"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07213986","su":"https://scitrials.org/trial/NCT07213986"},{"n":"NCT03598504","t":"Vibration for Muscle Spasms After Spinal Cord Injury","d":"This study uses closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms after spinal cord injury (SCI), and to understand the mechanisms responsible for spasm generation change in response to vibration.","s":"Unknown","tr":[],"o":["Spasticity"],"st":["Illinois"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT03598504","su":"https://scitrials.org/trial/NCT03598504"},{"n":"NCT06290609","t":"Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury","d":"The purpose of our study is to evaluate vibrotactile Coordinated Reset (vCR) and its effects on spasticity symptoms in incomplete spinal cord injured patients. vCR will be administered with a device called the Stanford CR Glove. vCR is expected to provide patients with a non-invasive alternative to the most widely used treatments such as oral baclofen and or deep brain stimulation. Patients will be followed for three months and will be asked to come to the lab for clinical testing 4 times…","s":"Not yet recruiting","tr":[],"o":["Spasticity"],"st":["California"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06290609","su":"https://scitrials.org/trial/NCT06290609"},{"n":"NCT06306352","t":"Vibrotactile Feedback in Exoskeletons","d":"This study aims to investigate the impact of providing discrete vibrotactile feedback related to weight shift and step initiation on exoskeleton use in individuals with motor-complete SCI.","s":"Completed","tr":["Devices","Exoskeleton"],"o":["Walking Function"],"st":[],"co":["Netherlands"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06306352"},{"n":"NCT06295146","t":"Virtual Peer Coaching in Manual Wheelchair Skills","d":"The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained. Then, trainees will be enrolled into one of three interventions: intervention with remote feedback (Group 1), and a wait list control group (Group 2).","s":"Recruiting","tr":["Devices"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06295146","su":"https://scitrials.org/trial/NCT06295146"},{"n":"NCT00951509","t":"Virtual Reality Based Testing of Power Wheelchair Driving Skills","d":"The purpose of this research study is to examine whether computer based or virtual reality based driving assessments are as useful as real-world power wheelchair driving tests in measuring driving performance and whether they may be useful in helping to identify the problems that some individuals may have with driving power wheelchairs. The specific aims are as follows: Specific Aim 1: To develop computer-based and VR-based wheelchair driving assessments for both drivers and non-drivers that…","s":"Completed","tr":["Observational"],"o":[],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00951509"},{"n":"NCT07019207","t":"Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation","d":"Spinal cord injury (SCI) is a severe neurological condition characterized by the loss of motor and sensory functions due to damage in the spinal cord or the nerves branching from it. Although studies investigating cognitive function after SCI are limited, it has been reported that up to 60% of individuals experience cognitive impairments. Because of impaired motor control, patients may need to invest more cognitive effort to perform even simple movements. This situation can negatively affect…","s":"Not yet recruiting","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07019207"},{"n":"NCT03592394","t":"Virtual Reality for Chronic Neuropathic Pain","d":"The investigators hypothesize that SCI patients using immersive IVR training will show improved reduction of neuropathic pain that will outlast the training sessions and transfers into daily life.","s":"Unknown","tr":[],"o":["Pain Management"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03592394","su":"https://scitrials.org/trial/NCT03592394"},{"n":"NCT06838975","t":"Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders","d":"This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD). It investigates whether VR improves motor and cognitive functions more than traditional therapy, identifies neurophysiological changes (EEG, fNIRS, MRI), and assesses the integration of VR with NIBS or telerehabilitation. Conducted over three years at IRCCS Centro…","s":"Active, not recruiting","tr":["Rehabilitation"],"o":[],"st":[],"co":["Italy"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06838975","su":"https://scitrials.org/trial/NCT06838975"},{"n":"NCT06154122","t":"Virtual Reality Upper Limb Therapy for People With Spinal Cord Injury","d":"This study aims to test if the VR games could be a form of upper limb rehabilitation for people with arm/hand problems due to SCI while they are in hospital. Participants who have had a spinal cord injury and have tetraplegia will be recruited from the Queen Elizabeth National Spinal Injuries Unit. After they have provided informed consent, they will receive 12 weeks of either standard upper limb therapy ('control group'), or both the VR activities and standard treatment ('VR Group')…","s":"Completed","tr":["Rehabilitation"],"o":["Arm Movement","Hand Movement"],"st":[],"co":["United Kingdom"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06154122","su":"https://scitrials.org/trial/NCT06154122"},{"n":"NCT03735017","t":"Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury","d":"This study will examine the effectiveness of one of two virtual reality treatments on neuropathic pain in individuals with spinal cord injury.","s":"Completed","tr":[],"o":["Mental Health","Pain Management","Quality of Life","Walking Function"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03735017"},{"n":"NCT01491789","t":"Virtual Sailing Simulator in Individuals With Spinal Cord Injury","d":"The research is being done to look at the benefits of a recreational and therapeutic program for people with spinal cord injury using the VSail-Access sailing simulator.","s":"Completed","tr":["Devices"],"o":["Hand Movement","Quality of Life","Trunk Control"],"st":["Maryland"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01491789"},{"n":"NCT06040749","t":"Virtual Sport for Adults ≥ 50 Years With Spinal Cord Injury","d":"Sport is a physical activity that has many physical, psychological and social benefits for those with spinal cord injury (SCI). However, most sport research involves people with SCI who are \\<50 years old. This is a problem because many people are \\>50 years old when first injured. Moreover, people with a SCI are now living longer lives, meaning they also experience more health challenges. Unfortunately, there is limited research studying the impact of sport for adults with SCI aged ≥50 years…","s":"Completed","tr":[],"o":["Mental Health","Quality of Life"],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06040749"},{"n":"NCT07254767","t":"Virtual Walking and Neuromulation to Reduce Neuropathic Pain After a Spinal Cord Injury","d":"The goal of this single-subject design is to evaluate an intervention combining neuromodulation, virtual reality, and muscle vibration to reduce neuropathic pain in individuals following a spinal cord injury. The investigators aim to quantify the effects of the intervention on the intensity and characteristics of neuropathic pain, as well as its impact on daily functioning in individuals undergoing SCI rehabilitation. Additionally, the investigators seek to gain a better understanding of…","s":"Not yet recruiting","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Pain Management"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07254767","su":"https://scitrials.org/trial/NCT07254767"},{"n":"NCT06710808","t":"VIRTUAL WALKING AND TRANSCRANIAL DIRECT CURRENT STIMULATION FOR CHRONIC NEUROPATHIC PAIN DUE TO SPINAL CORD INJURY","d":"The goal of this feasibility study is to assess the feasibility of the combined treatment intervention \"virtual walking (VW) and transcranial direct current stimulation (tDCS)\" of neuropathic pain in patients with spinal cord injury. The main question aims to answer: • To assess the feasibility of combining VW and tDCS for longer-term use from the patients' point of view. Participants will: Receive a two week intervention in the Swiss Paraplegic Centre in Nottwil, where the participants undergo…","s":"Completed","tr":["Transcranial Direct Current Stimulation (tDCS)"],"o":["Mental Health","Pain Management","Walking Function"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT06710808"},{"n":"NCT01884662","t":"Virtual Walking for Neuropathic Pain in Spinal Cord Injury","d":"Spinal cord injury neuropathic pain (SCI-NP) is a common problem, and when severe, is one of the most problematic of secondary conditions that is minimally to modestly responsive to currently available treatments. It is usually described as burning or stabbing, and is located at or below the level at which their sensation changes from normal to impaired; persons with no feeling at all in their legs for example can experience pain in the legs. The purpose of this project is to further…","s":"Completed","tr":[],"o":["Pain Management","Sensory Function","Walking Function"],"st":["Alabama"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01884662"},{"n":"NCT05005026","t":"Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury","d":"The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.","s":"Recruiting","tr":["Rehabilitation"],"o":["Pain Management"],"st":["Alabama","Texas"],"co":["Australia","United States"],"lc":3,"rlc":2,"cu":"https://clinicaltrials.gov/study/NCT05005026","su":"https://scitrials.org/trial/NCT05005026"},{"n":"NCT06330181","t":"Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury","d":"The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with incomplete spinal cord injury.","s":"Recruiting","tr":[],"o":["Pain Management"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06330181","su":"https://scitrials.org/trial/NCT06330181"},{"n":"NCT07165353","t":"Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI","d":"About 70% of people with a spinal cord injury in Switzerland have chronic pain that lasts more than 3 to 6 months. This pain can be caused by muscle or joint problems, or by nerve damage (neuropathic pain). Neuropathic pain is often hard to treat, and current treatments may cause side effects or not work well. This study will test whether virtual walking from different visual perspectives can reduce chronic neuropathic pain and improve quality of life after spinal cord injury. We will also…","s":"Recruiting","tr":[],"o":["Pain Management"],"st":[],"co":["Switzerland"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07165353","su":"https://scitrials.org/trial/NCT07165353"},{"n":"NCT01958086","t":"Visuomotor Prosthetic for Paralysis","d":"The investigators objective is to run human clinical trials in which brain activity recorded through a \"brain-chip\" implanted in the human brain can be used to provide novel communication capabilities to severely paralyzed individuals by allowing direct brain-control of a computer interface. A prospective, longitudinal, single-arm early feasibility study will be used to examine the safety and effectiveness of using a neural communication system to control a simple computer interface and a…","s":"Recruiting","tr":["Brain Stimulation"],"o":[],"st":["California"],"co":["United States"],"lc":3,"rlc":3,"cu":"https://clinicaltrials.gov/study/NCT01958086","su":"https://scitrials.org/trial/NCT01958086"},{"n":"NCT02720341","t":"VIT-ARMin Virtual, Intensified and Patient-tailored Robotic Arm Therapy With the Exoskeleton Robot ARMin","d":"Consideration-of-Concept Trial (stage 1) on robotic therapy of the upper extremity with the ARMin therapy robot in healthy subjects and patients with neurological disease (e.g. stroke, spinal cord injury)","s":"Terminated","tr":["Exoskeleton"],"o":["Arm Movement","Motor Function"],"st":[],"co":["Switzerland"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02720341"},{"n":"NCT00869427","t":"Vitamin C for Prevention of Urinary Tract Infections in the Spinal Cord Injured","d":"After spinal cord injury, patients have frequent urinary tract infections (UVI). Vitamin C is usually prescribed to prevent such infection, but the efficacy of the treatment is poorly documented. In the study, patients will be randomised either to receive vitamin C daily, or not, for one year, and clinical episodes of UVI will be registered. The null hypothesis is that vitamin C will not reduce the number of UVI episodes by 30%.","s":"Terminated","tr":["Drugs"],"o":["Bladder Function"],"st":[],"co":[],"lc":0,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00869427"},{"n":"NCT00857831","t":"Vitamin D and Calcium Study","d":"Vitamin D aids in the body's ability to absorb calcium, it is a vital component in bone formation and break down. Reduced levels of vitamin D can indicate a vitamin deficiency and may depress serum calcium levels. The following is a list of common causes of vitamin D deficiency: lack of dairy products, alcohol usage, elderly, lack of exposure to sunlight, individuals with reduced mobility, GI malabsorption problems, dark complexion, severe liver damage, and renal failure. Many of these factors…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)","Nutrition"],"o":["Bone Strength"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00857831"},{"n":"NCT02099955","t":"Vitamin D Deficiency and Replacement on Pulmonary and Endocrine Function in SCI","d":"Studies have shown that individuals who have suffered a spinal cord injury are at an increased risk of Vitamin D deficiency compared to able-bodied individuals. It has recently been shown that Vitamin D deficiency is linked to a large number of diseases and conditions, including chronic lung disease, vascular problems, and insulin resistance. If this common nutritional deficiency is proven to be the cause of some of these diseases and conditions in persons with SCI, then it may easily be…","s":"Completed","tr":["Drugs","Nutrition"],"o":["Breathing Function"],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02099955"},{"n":"NCT04652544","t":"Vitamin D Supplementation in Individuals With a Chronic Spinal Cord Injury","d":"The main objective of this placebo-controlled randomized double-blinded study is to investigate the effect of vitamin D supplementation on vitamin D status (25(OH)D concentration in the blood) among individuals with a chronic spinal cord injury (SCI). Further, the effects of vitamin D supplementation on several other parameters (e.g. bone density and mood) are investigated, which could reveal positive secondary effects of supplementation that are especially relevant for clinical practice.","s":"Completed","tr":["Drugs","Nutrition"],"o":["Bone Strength","Mental Health","Pain Management","Pressure Sores"],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT04652544"},{"n":"NCT02621320","t":"Vitamin D Supplementation in Wheelchair Indoor Athletes","d":"There is a high prevalence of vitamin D deficiency in Switzerland. In indoor-athletes as well as wheelchair users, vitamin D deficiency occurs even more often. It is well established that vitamin D deficiency has a negative effect on health. However, vitamin D supplementation in individuals with a vitamin D deficiency has a positive effect on muscle performance. In recently published studies with able-bodied subjects, it has been shown that a normal vitamin D level (\\>75nmol/L) can only be…","s":"Completed","tr":["Drugs","Nutrition"],"o":[],"st":[],"co":["Switzerland"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02621320"},{"n":"NCT03284086","t":"VO2peak and Exercise Efficiency in Upper-body Poling","d":"This study compares peak oxygen uptake (VO2peak) and exercise efficiency in upper-body poling versus arm crank ergometry in trained able-bodied and paraplegic participants.","s":"Completed","tr":[],"o":[],"st":[],"co":["Norway"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03284086"},{"n":"NCT07224256","t":"VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration","d":"The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate. The Neuralink N1 Implant is intended to provide the ability to communicate to individuals with severe and irreversible speech production impairment. It is indicated for adults with neurological conditions of the central speech pathways who have impaired upper limb function. The N1 Implant is a skull-mounted…","s":"Recruiting","tr":["Brain Machine Interface (BMI)","Devices"],"o":["Arm Movement"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07224256"},{"n":"NCT06587607","t":"VR Mindfulness Training for Veterans With SCI","d":"This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA CALM program more accessible for those with SCI. It will involve delivering the unmodified curriculum to a group of Veterans with SCI first to determine what areas need accommodations, working with a group of stakeholders to develop appropriate accommodations, and then…","s":"Recruiting","tr":[],"o":["Mental Health"],"st":["Texas"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06587607","su":"https://scitrials.org/trial/NCT06587607"},{"n":"NCT07141784","t":"VR-Integrated C-Mill® Combined With Conventional Therapy in Motor-Incomplete SCI","d":"This study investigates the effects of C-Mill® treadmill training, which integrates virtual reality and gamified tasks, combined with conventional physiotherapy, on walking ability, mobility, functional independence, and health-related quality of life in individuals with motor-incomplete spinal cord injury (iSCI). Participants are adults aged 18 years or older with injury at the T4 level or below, classified as American Spinal Injury Association (ASIA) Impairment Scale grade C or D, and with…","s":"Completed","tr":["Devices","Rehabilitation"],"o":["Bone Strength","Leg Movement","Motor Function","Quality of Life","Trunk Control","Walking Function"],"st":[],"co":["Turkey (Türkiye)"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07141784"},{"n":"NCT03940274","t":"Walk-Training Program for Individuals With Chronic Spinal Cord Injury (SCI)","d":"Cardiovascular disease (CVD) is the common leading cause of death among people with spinal cord injury (SCI) and occurs at an early age in people with SCI as compared to able-bodied people. The findings are consistent in demonstrating a high prevalence of CVD among people with SCI. Lack of physical activity and/or prolonged sitting which is observed in people with SCI due to impaired/loss of motor function is associated with increased risk factors of CVD. By doing this study, researchers hope…","s":"Completed","tr":[],"o":["Blood Pressure","Motor Function","Spasticity","Walking Function"],"st":["Kansas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03940274"},{"n":"NCT01851629","t":"Walking Adaptability Post-Spinal Cord Injury","d":"The purpose of this study is: (1) to establish assessment techniques (in our laboratory) to identify the functional integrity of long spinal tracts associated with adaptive walking recovery post-spinal cord injury and (2) to preliminary investigate locomotor outcomes associated with an adaptive locomotor training approach post-spinal cord injury.","s":"Completed","tr":["Rehabilitation"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":4,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01851629"},{"n":"NCT03504826","t":"Walking Rehabilitation After Spinal Cord Injury: Locomotor Training Using Adaptive Robotics","d":"Locomotor training is an established rehabilitation approach that is beneficial for improving walking function in individuals with spinal cord injuries (SCIs). This approach focuses on repetitive practice and appropriate stepping movements to activate spinal neural networks and promote rhythmic motor output associated with walking. Assistance with stepping movements is often provided by physical therapists and trainers, but this can be costly and difficult to deliver in the cost-constrained…","s":"Unknown","tr":["Exoskeleton"],"o":["Walking Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03504826","su":"https://scitrials.org/trial/NCT03504826"},{"n":"NCT05669508","t":"Wearable Electrical Stimulation on the Back to Modulate Spinal Cord Activity","d":"The goal of this study is to evaluate if non-invasive electrical spinal stimulation can help people with paralysis caused by SCI improve strength and function of their arms, legs, hands or feet. The study will involve therapy sessions involving exercises done at the same time as electrical stimulation therapy. This study has multiple parts to evaluate the effectiveness and safety of \"smart\" electrical stimulation of the spinal cord, which involves stimulating the spinal cord at precise…","s":"Active, not recruiting","tr":["Rehabilitation","Transcutaneous Stimulation"],"o":["Arm Movement","Hand Movement"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05669508","su":"https://scitrials.org/trial/NCT05669508"},{"n":"NCT05068648","t":"Wheelchair Backs That Support the Spinal Curves","d":"The overall objective of this fully powered clinical trial is to investigate if using a solid backrest on a manual wheelchair (MWC) will improve postural alignment, function and wheelchair mobility, as compared with an upholstery backrest, and to explore the impact of overall back height, contour, and seat gap when using a solid backrest in individuals with spinal cord injury (SCI).","s":"Completed","tr":[],"o":[],"st":["Colorado","Illinois","New Jersey"],"co":["United States"],"lc":3,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT05068648"},{"n":"NCT03430375","t":"Wheelchair Cushion Comparison Study: SAFETY","d":"Purpose: To examine the safety of the use of two wheelchair cushions for healthy individuals with intact sensation and individuals post stroke and spinal cord injury with impaired sensation. The new Ease Alternating Pressure wheelchair cushion will be compared to a static air cushion to examine interface pressure and skin responses in the areas of the buttock and posterior thighs when subjects sit without moving (static condition) and during upper extremity reaching activities (active…","s":"Completed","tr":["Devices"],"o":["Arm Movement","Sensory Function"],"st":["Michigan"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03430375"},{"n":"NCT02550834","t":"Wheelchair Indoors Curling With SCI patients_RCT","d":"This study investigates if, patients with diagnosed chronic spinal cord injury will benefit from an Indoor Curling Exercise program on their control capabilities of trunk movements and on their intrinsic motivation for physical activity. Half of participants will receive 8 training-sessions during 4 weeks, while the other will receive usual care.","s":"Completed","tr":[],"o":["Trunk Control"],"st":[],"co":["Switzerland"],"lc":2,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02550834"},{"n":"NCT01204047","t":"Wheelchair Mobility Assessment of Individuals With Spinal Cord Injury","d":"The specific aims of this study are: 1) to assess the test-retest reliability of a modification of an existing wheelchair propulsion assessment and 2) validate the modification against traditional measures of physical strength, power, and endurance in a group of persons with spinal cord injury (SCI).","s":"Completed","tr":["Observational"],"o":["Blood Pressure","Motor Function"],"st":["Florida"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01204047"},{"n":"NCT00280306","t":"White Matter Fiber Tracking and Assessment of White Matter Integrity in the Cervical Spinal Cord","d":"White matter fiber tracking may provide a novel tool to assess the integrity of injured motor tracts in the cervical spine. It provides information about fiber directions which is not given by conventional MRI. White matter fiber tracking in the brain is used at several institutions, including our own medical college, for presurgical planning of tumor excision. We believe that the technical and clinical experience gained for the brain can be applied to fiber tracking in the cervical spine as…","s":"Completed","tr":["Observational"],"o":[],"st":["New York"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT00280306"},{"n":"NCT03411720","t":"Whole Body Exercise in Spinal Cord Injury: Effects on Psychosocial Function","d":"Persons with spinal cord injury (SCI) are confronted with a multitude of psychological and physiological changes post-injury leading to seemingly insurmountable barriers to participating in daily life. After injury persons with SCI engage in fewer social interactions, spend more time sedentary, and are less likely to leave the home. This leads to restricted social participation that, in turn, contributes to greater psychological problems and negatively impacts the lives of adults with SCI…","s":"Completed","tr":["Electrical Stimulation","Functional Electrical Stimulation (FES)"],"o":["Mental Health","Pain Management","Quality of Life"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03411720"},{"n":"NCT03189095","t":"Workout on Wheels Internet Intervention (WOWii)","d":"Project WOWii examines how useful and effective an online format is for helping people with SCI get more exercise over 4 months. Study participants will meet over Skype weekly for 16 weeks and work through weekly online modules to start and stick with an accessible and individualized exercise program. Participants will be compensated for their time to attend fitness testing and complete surveys before and just after the 16-week program.","s":"Completed","tr":["Rehabilitation"],"o":[],"st":["Texas"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT03189095"},{"n":"NCT05321017","t":"Wrist Extensor MEP Up-conditioning for Individuals With Incomplete Spinal Cord Injury","d":"The purpose of this study is to examine the relationship between common clinical assessments and measurements of the function of brain-spinal cord-muscle connections, and to examine the effects of training a brain-spinal cord-muscle response in individuals with incomplete spinal cord injury. A transcranial magnetic stimulator (TMS) is used for examining brain-to-muscle pathways. This stimulator produces a magnetic field for a very short period of time and indirectly stimulates brain cells with…","s":"Recruiting","tr":["Brain Stimulation"],"o":["Hand Movement"],"st":["South Carolina"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT05321017","su":"https://scitrials.org/trial/NCT05321017"},{"n":"NCT07380516","t":"Xo-Motion R Exoskeleton in SCI-Adoption Study","d":"After spinal cord injury (SCI), many people lose their ability to walk and do not have access to equipment and assistance that could help them regain functional abilities. Furthermore, many who have the potential to regain function are further hindered by a loss of function in their upper body that limits their ability to use a walker or crutches, thus eliminating options for mobility. This study seeks to determine the safety and feasibility of the XoMotion-R, a self-balancing exoskeleton that…","s":"Not yet recruiting","tr":["Exoskeleton","Rehabilitation"],"o":[],"st":[],"co":["Canada"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT07380516","su":"https://scitrials.org/trial/NCT07380516"},{"n":"NCT06514950","t":"Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury","d":"The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with spinal cord injuries. Previously yogic breathing has shown to improve respiratory function and sleep- we'd like to explore this further. The main questions this study aims to answer are: * How does Ujjayi breathing affect breathing patterns in individuals with spinal cord…","s":"Recruiting","tr":[],"o":["Breathing Function"],"st":["Massachusetts"],"co":["United States"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT06514950","su":"https://scitrials.org/trial/NCT06514950"},{"n":"NCT07750808","t":"ZEPU AI9 Exoskeleton Rehabilitation Robot","d":"The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic surgery. The main questions it aims to answer are: Is exoskeleton-assisted gait training well tolerated, and how often do device-related problems (such as falls, pain, or skin injury) occur? Does adding exoskeleton training to usual rehabilitation improve walking distance…","s":"Recruiting","tr":["Devices","Exoskeleton","Rehabilitation","Surgical Procedure"],"o":["Leg Movement","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07750808"},{"n":"NCT07749612","t":"ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)","d":"The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs. These devices are used to guide repeated arm and leg movements as part of rehabilitation therapy. The study will also look at whether the devices are safe to use. The main questions it aims to answer are: Is training with the ZEPU-2000 devices safe, and how well do patients tolerate and stick with the…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Leg Movement","Motor Function","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07749612"},{"n":"NCT07749625","t":"ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)","d":"The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems. These problems can result from stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic surgery. The main questions it aims to answer are: Is robotic rehabilitation training safe and practical to deliver alongside conventional therapy? Does adding robotic-assisted therapy…","s":"Recruiting","tr":["Devices","Rehabilitation","Surgical Procedure"],"o":["Arm Movement","Hand Movement","Leg Movement","Motor Function","Pain Management","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07749625"},{"n":"NCT07735676","t":"ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)","d":"Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence. Robotic-assisted gait training devices, which use a computer-controlled system to help patients practice standing and walking, have shown promise in improving strength, balance, and walking ability in other countries. However, this type of technology has not yet been carefully studied in Bangladesh. This study will test a robotic gait training and evaluation…","s":"Recruiting","tr":["Devices","Exoskeleton","Rehabilitation","Surgical Procedure"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07735676"},{"n":"NCT07705906","t":"ZEPU-AI3 Lower Limb Feedback Robot Training Study","d":"Lower limb motor dysfunction resulting from stroke, spinal cord injury, or other neurological disorders substantially limits mobility, independence, and quality of life. Robotic rehabilitation has emerged as a promising approach to provide intensive, repetitive, task-oriented training. The ZEPU-AI3 Lower Limb Feedback Training and Evaluation Robot is designed to deliver interactive lower limb training while providing real-time performance feedback. This pilot randomized controlled trial aims to…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07705906"},{"n":"NCT07735702","t":"ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)","d":"The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to stroke, incomplete spinal cord injury, or persistent gait impairment following orthopedic surgery. The main questions it aims to answer are: Is robot-assisted training using the ZEPU-AI5 device safe and well-tolerated, with an acceptable rate of device-related adverse…","s":"Recruiting","tr":["Devices","Rehabilitation","Surgical Procedure"],"o":["Leg Movement","Motor Function","Quality of Life","Spasticity","Trunk Control","Walking Function"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07735702"},{"n":"NCT07739264","t":"ZEPU-SGI1PLUS Hand Training Study (ZEPUSGI1RCT)","d":"The goal of this pilot randomized controlled trial is to learn whether the ZEPU-SG1PLUS Hand Functional Comprehensive Training System - a robotic device used alongside standard rehabilitation - is safe, feasible, and helpful for people with upper limb (arm/hand) motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. The main questions it aims to answer are: Is robotic-assisted hand training well tolerated by patients, and can it be…","s":"Recruiting","tr":["Devices","Rehabilitation"],"o":["Arm Movement","Hand Movement","Motor Function","Quality of Life","Spasticity"],"st":[],"co":["Bangladesh"],"lc":1,"rlc":1,"cu":"https://clinicaltrials.gov/study/NCT07739264"},{"n":"NCT02042872","t":"Zoledronic Acid Administration in Acute Spinal Cord Injury","d":"In subjects with acute SCI: To compare the effects of parenteral zoledronic acid therapy on preservation of regional and total skeletal mass (DXA). Hypothesis: Zoledronic acid will dramatically diminish bone loss in persons with acute SCI, as evidenced by serial densitometry determinations (DXA).","s":"Completed","tr":["Drugs"],"o":["Bone Strength"],"st":["New Jersey"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT02042872"},{"n":"NCT01642901","t":"Zoledronic Acid in Acute Spinal Cord Injury","d":"Maintenance of bone mass following spinal cord injury (SCI) is essential to fracture prevention and the associated morbidity of bed rest and further secondary complications. Intravenous (IV) zoledronic acid (ZA) is an FDA-approved drug that has been shown to be more effective than other agents in reducing bone mass resorption and leg fractures in post-menopausal women, but has not been studied in patients with acute SCI. This will be a randomized, double-blind, placebo-controlled trial of IV ZA…","s":"Completed","tr":["Drugs","Safety"],"o":["Bone Strength"],"st":["Pennsylvania"],"co":["United States"],"lc":1,"rlc":0,"cu":"https://clinicaltrials.gov/study/NCT01642901"}]}