SCI Clinical Trials in California
116 spinal cord injury clinical trials list a study site in California, and 27 are currently open to new participants. Every trial below links to its full ClinicalTrials.gov record for eligibility, contacts and exact locations. Trial sites are tracked at state level, so a listed trial may run at one hospital in California or several. Last refreshed 2026-09-12.
Open these in the Trials Finder → Filter by treatment, target, and status, or sort by distance.
Also in California: inpatient SCI rehab facilities in California · adaptive sports and support organizations · wheelchair van dealers
Browse SCI trials by what they study
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Open and recruiting (27)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- RecruitingNCT06841770
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI).
2 US sites · California - Not yet recruitingNCT07799532
A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury
The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291.
18 US sites · Alabama, California, Colorado, Connecticut… - Not yet recruitingNCT07209943
Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro
The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI) or spinal cord injury (SCI) that have assistive communication and…
1 US site · California - RecruitingNCT00912041
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.
6 US sites · California, Georgia, Massachusetts, Rhode Island… - RecruitingNCT04144972
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target only brain regions involved in one aspect of the…
1 US site · California - RecruitingNCT07357428
Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)
The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI).
3 US sites · California, Massachusetts, Michigan - RecruitingNCT06596291
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization
This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI),…
5 US sites · California, Michigan, Ohio, Pennsylvania… - Enrolling by invitationNCT07280351
Duraplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn if a procedure called "expansile duraplasty" can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI).
1 US site · California - RecruitingNCT03698149
ECoG BMI for Motor and Speech Control
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
1 US site · California - RecruitingNCT05724173
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.
2 US sites · California, Massachusetts - RecruitingNCT06094205
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to speak fluently to communicate via a computer just by trying to speak.
1 US site · California - Enrolling by invitationNCT07030322
Health and Financial Impact on the Use of a Personal Exoskeleton in the Home and Community: a Case Study
The goal of this clinical trial is to examine the long-term use of a personal overground robotic exoskeleton in subjects with spinal cord injury. The main aims of this study include: 1. Determine patterns of personal overground robotic exoskeleton use over 12 months. 2.
1 US site · California - RecruitingNCT06529094
Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at high risk of pressure injury (PrI) throughout their lives due to loss of sensation, nerve damage and immobility.
7 US sites · California, Florida, Illinois, Missouri… - RecruitingNCT02331979
Improving Bladder Function in SCI by Neuromodulation
This trial will investigate the safety and utility of spinal cord neuromodulation to improve urinary bladder function in the context of spinal cord injury.
1 US site · California - Not yet recruitingNCT07227285
Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy
The aim of this study is to continue following participants who have received EG110A during five years to know how it is tolerated in humans, any side-effects it may cause and what might be an effective dose over five years.
4 US sites · California, Michigan, Pennsylvania, Texas - RecruitingNCT06288763
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
10 US sites · California, Florida, Maryland, Michigan… - RecruitingNCT06541041
Nerve Transfers Plus Electrical Stimulation to Improve Hand Function in Cervical Spinal Cord Injury
The goal of this prospective observational study is to determine whether brief intraoperative electrical stimulation and temporary postoperative electrical stimulation improve motor and/or pain outcomes for patients with cervical spinal cord injury undergoing standard of care nerve transfer surgery…
1 US site · California - RecruitingNCT04883463
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach.
2 US sites · California - RecruitingNCT05491525
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
38 US sites · Arkansas, California, Colorado, Florida… - RecruitingNCT07674927
Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury
This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI. Up to 15 participants aged 18 years or older with non-progressive SCI will be enrolled.
1 US site · California - Enrolling by invitationNCT06583395
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and clinical populations.
1 US site · California - RecruitingNCT07090473
Safety of Transcutaneous Electrical Stimulation Potentiating Recovery in Acute Spinal Cord Injury Syndromes
The goal of this study is to test whether electrical stimulation from the skin surface starting 3 days after spinal cord injury (SCI) is safe and may help patients recover their movement.
1 US site · California - RecruitingNCT01964261
Sensory Motor Transformations in Human Cortex
This research study is being conducted to develop a brain controlled medical device, called a brain-machine interface. The device will provide people with a spinal cord injury some ability to control an external device such as a computer cursor or robotic limb by using their thoughts along with…
4 US sites · California, Colorado - RecruitingNCT07222046
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence.
1 US site · California - Enrolling by invitationNCT04565366
Transforming Research and Clinical Knowledge in Spinal Cord Injury
The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics of acute traumatic spinal cord injury (SCI).
5 US sites · California, Ohio, Utah, Washington - Not yet recruitingNCT06290609
Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury
The purpose of our study is to evaluate vibrotactile Coordinated Reset (vCR) and its effects on spasticity symptoms in incomplete spinal cord injured patients. vCR will be administered with a device called the Stanford CR Glove.
1 US site · California - RecruitingNCT01958086
Visuomotor Prosthetic for Paralysis
The investigators objective is to run human clinical trials in which brain activity recorded through a "brain-chip" implanted in the human brain can be used to provide novel communication capabilities to severely paralyzed individuals by allowing direct brain-control of a computer interface.
3 US sites · California
Running, but closed to new participants (9)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT02978638
Electrical Stimulation for Continence After Spinal Cord Injury
This study aims to improve continence and voiding of patients with spinal cord injury using electrical stimulation. The Finetech Vocare Bladder System is an implantable sacral nerve stimulator for improving bladder and bowel function in patients with spinal cord injury (SCI).
4 US sites · California, New Mexico, Ohio - Active, not recruitingNCT05653206
Incomplete Cervical SCI Without Instability
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of additional core and optional outcome assessments in…
10 US sites · California, Maryland, Wisconsin - Active, not recruitingNCT05919563
LTFU Study of Subjects Who Received GRNOPC1
This is a LTFU study for thoracic SCI subjects that were administered GRNOPC1 cells in the main study CP35A007.
3 US sites · California, Georgia, Illinois - Active, not recruitingNCT05975424
LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1
This is a LTFU study for cervical SCI subjects that were administered AST-OPC1 cells in the main study AST-OPC1-01.
6 US sites · California, Georgia, Illinois, Pennsylvania… - Active, not recruitingNCT04023591
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a significant public health impact.
9 US sites · California, Florida, Michigan, Missouri… - Active, not recruitingNCT02313194
Spinal Cord Neuromodulation for Spinal Cord Injury
This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.
1 US site · California - Active, not recruitingNCT05468437
Telenutrition for Individuals With SCI
This study will provide nutrition counseling via FaceTime on an iPad to persons with traumatic spinal cord injury (SCI) who are overweight or obese and are at least one-year post-injury.
1 US site · California - Active, not recruitingNCT06069999
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
5 US sites · California, Florida, Pennsylvania, Utah - Active, not recruitingNCT05593237
Transcranial Magnetic Stimulation for Chronic Neuropathic Pain
Chronic neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system. It is highly prevalent, debilitating, and challenging to treat. Current available treatments have low efficacy, high side effect burden, and are prone to misuse and dependence.
1 US site · California
Completed and closed (80)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Completed NCT00407745 A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
- Completed NCT00557973 A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury
- Completed NCT01337908 A Study of Mood and Stress After Spinal Cord Injury
- Terminated NCT00712322 A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
- Completed NCT03989440 AXER-204 in Participants With Chronic Spinal Cord Injury
- Completed NCT04141891 Advancing Understanding of Transportation Options
- Terminated NCT01407341 Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
- Unknown NCT03911492 Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
- Completed NCT00786435 Carbohydrate Study, Chronic SCI
- Completed NCT00013325 Cardiac Disease and the Electrocardiogram in SCI Patients
- Completed NCT03029884 Closed-loop Deep Brain Stimulation to Treat Refractory Neuropathic Pain
- Completed NCT00318591 Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections
- Terminated NCT01433159 Comparison of HP011-101 to Standard Care for Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury
- Completed NCT00047580 Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
- Completed NCT03626324 Connected Catheter (C2P) Study for Bladder Management
- Terminated NCT04059159 Connected Catheter - Safety and Effectiveness Study
- Completed NCT03405285 Connected Catheter Clinical Feasibility Study( CFS)
- Terminated NCT03843073 Connected Catheter- Safety and Effectiveness Study
- Completed NCT01345019 Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
- Completed NCT02302157 Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
- Terminated NCT04217577 Dried Plum Supplementation as Treatment for Bone Loss Following Spinal Cord Injury
- Terminated NCT02660138 Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1
- Unknown NCT01386762 Effect of Intense Multi-modal Training on Bone Health and Quality of Life in Persons With Spinal Cord Injury
- Unknown NCT00256672 Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
- Terminated NCT00332319 Effects Of GW679769 On Bladder Nerve Function And Symptoms Of Overactive Bladder In Spinal Cord Injury Patients
- Completed NCT01037088 Effects of Vaporized Marijuana on Neuropathic Pain
- Completed NCT02473614 Efficacy Study of the Music Glove Patients With Spinal Cord Injuries
- Terminated NCT04815967 Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
- Completed NCT05945784 Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
- Terminated NCT00786968 Extension Study of Intrathecal Enzyme Replacement Therapy for MPS I
- Completed NCT02008149 FES Rowing for Skeletal Health After SCI
- Completed NCT00011557 Functional Magnetic Micturition in Patients w/SCI
- Completed NCT00507546 Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
- Completed NCT00786604 Glucose Study, Spinal Cord Injury
- Unknown NCT03469141 Interactive Telehealth for Pressure Ulcer Prevention After SCI
- Unknown NCT04266808 Interactive Telehealth for Wheelchair Users
- Terminated NCT00215527 Intrathecal Enzyme Replacement Therapy for Spinal Cord Compression in Mucopolysaccharidosis (MPS) I
- Terminated NCT02566850 Investigational Study of the Ekso for High-Dosage Use by Individuals With SCI in a Non-Clinical Environment
- Completed NCT02135978 Maintenance of Shoulder Health and Function After Spinal Cord Injury
- Completed NCT04668326 Mobile Manual Standing Wheelchair for SCI
- Completed NCT02768103 Neural Adaptation After Tendon Transfer and Training in Tetraplegia
- Terminated NCT00101361 Oxandrolone to Heal Pressure Ulcers
- Completed NCT00786786 Perceived Barriers to Exercise in Individuals Living With Spinal Cord Injury
- Completed NCT03175055 Phoenix Exoskeleton for SCI Users
- Completed NCT02658656 Powered Exoskeletons in Persons With SCI
- Completed NCT01999816 Pressure Ulcer Prevention Study in SCI
- Completed NCT01849822 Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia
- Completed NCT02878850 Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
- Unknown NCT02944669 ReWalk Personal Device Postmarket Study
- Completed NCT01906424 Restoring Arm and Hand Function With Non-invasive Spinal Stimulation
- Terminated NCT01597518 Riluzole in Spinal Cord Injury Study
- Completed NCT01141647 SCI-VIP: Predictive Outcome Model Over Time for Employment (PrOMOTE)
- Terminated NCT03083366 Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
- Completed NCT04295538 Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
- Completed NCT01217008 Safety Study of GRNOPC1 in Spinal Cord Injury
- Unknown NCT01772810 Safety Study of Human Spinal Cord-derived Neural Stem Cell Transplantation for the Treatment of Chronic SCI
- Completed NCT00041717 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT01683838 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT04096950 Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury
- Terminated NCT00531466 Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury
- Completed NCT00763282 Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)
- Completed NCT05301335 Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
- Terminated NCT02163876 Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury
- Terminated NCT03762655 Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
- Completed NCT00461474 Study of Strengthening Exercises and Improving Movement for Painful Shoulders in Adults With Spinal Cord Injury
- Completed NCT04683848 Study to Assess the Efficacy and Safety of MT-3921 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
- Terminated NCT02669849 Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
- Completed NCT01243125 Study to Evaluate NVC-422 for Urinary Catheter Blockage and Encrustation
- Completed NCT01502631 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI)
- Completed NCT03464409 Supporting Patient Decisions About UE Surgery in Cervical SCI
- Completed NCT03714217 Telenutrition in Spinal Cord Injury
- Completed NCT03711760 Telepsychology in Spinal Cord Injury
- Completed NCT01279811 The Canadian Multicentre CSF Monitoring and Biomarker Study
- Terminated NCT02138110 The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
- Completed NCT01949285 Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs
- Completed NCT00006429 Treadmill Training for Spinal Cord Injury
- Unknown NCT04000256 Understanding Experiences of People With Spinal Cord Injury Undergoing Activity-based Rehabilitation
- Completed NCT01537978 Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury
- Unknown NCT04097015 Using NI-ES to Treat Spinal Cord Injury (SCI)
- Completed NCT01555983 Vaporized Cannabis and Spinal Cord Injury Pain
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".