Epidural Stimulation Clinical Trials for Spinal Cord Injury
SCI.help tracks 81 spinal cord injury clinical trials studying epidural stimulation, and 46 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.
Open these in the Trials Finder → Add a target (walking, bladder, pain…), a state, or a status filter.
Other treatment categories
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Browse by state
- New York (161)
- Florida (139)
- Texas (119)
- California (116)
- Illinois (105)
- Pennsylvania (92)
- New Jersey (91)
- Ohio (83)
- Georgia (59)
- Massachusetts (59)
- Minnesota (55)
- Colorado (49)
- Michigan (48)
- Maryland (48)
- Washington (46)
- Kentucky (43)
- Virginia (41)
- Missouri (41)
- North Carolina (32)
- Alabama (32)
Open and recruiting (46)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- RecruitingNCT01474148
A Neuroprosthesis for Seated Posture and Balance
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips. FES involves applying small electric currents to the nerves, which cause the muscles to contract.
1 US site · Ohio - RecruitingNCT07147296
ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury
Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (\>1 year after SCI).
13 US sites · Arkansas, Colorado, Florida, Georgia… - RecruitingNCT07234903
ARC-IM Therapy To Support and Promote Recovery of Ambulatory Functions in People With Subacute and Chronic Spinal Cord Injury
The EIGER study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to support and promote recovery of ambulatory functions, such as walking, in people with subacute and chronic spinal cord injury.
Switzerland - RecruitingNCT06533969
Assessment of Neural Signals for the Control of Assistive Devices
The study will investigate the use of motor intention-based cortical signals to trigger epidural spinal cord stimulation (ESCS) with individuals with SCI.
2 US sites · Florida - RecruitingNCT04496609
Assessment of the Efficacy and Safety of EESS in Patients With Incomplete Spinal Cord Injuries
Neurological disability caused by traumatic lesions of the spinal cord is a significant challenge for medicine and society. These lesions, leading to sublesional central nervous system dysfunction, include sensorimotor, vesico-sphincter and genito-sexual disorders.
France - RecruitingNCT06225245
Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord
The goal of this study is to investigate the effects of cervical epidural spinal stimulation with upper extremity training. This is an investigational study. The device used for epidural spinal stimulation (ESS) to deliver spinal stimulation is called the CoverEdgeX 32 Surgical Lead system.
1 US site · Texas - RecruitingNCT06939660
BCI-Assisted SCS-EXS for Gait Optimization
The goal of this clinical trial is to evaluate the safety and technical feasibility of a novel brain-machine interface (BCI)-assisted spinal cord stimulation (SCS) and exoskeleton (EXS) system in patients with spinal cord injury (SCI).
China - RecruitingNCT05665998
Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation
Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function.
Switzerland - RecruitingNCT06410001
CE-STAND: Cervical Epidural STimulation After Neurologic Damage
CE-STAND aims to address three areas under-represented in research: chronic, cervical, and autonomic dysfunction. It is both significant and highly impactful, as treating autonomic dysfunction could substantially improve function and quality of life (QoL) in chronic cervical SCI patients.
1 US site · Minnesota - RecruitingNCT06725836
Clinical Testing of Invasive Spinal Cord Stimulation and Evaluation of Its Physiological Effects Using the Electroencephalography
The aim of the study is to identify the specific characteristics of brain network dysfunctions and assess the recovery of their functionality through the recording of resting-state electroencephalography (EEG) during rehabilitation using spinal cord stimulation (SCS).
Russia - RecruitingNCT04969042
Closed-loop Functional Spinal Cord Stimulation in Patients With Spinal Cord Injury
The purpose of this experiment is to evaluate the efficacy of Closed-loop Functional Spinal Cord Stimulation on Walking Rehabilitation in Patients after Spinal Cord Injury
China - RecruitingNCT07139496
Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation
Spinal cord stimulation (SCS) has been shown in previous studies to be capable of restoring motor and autonomic function in patients with chronic complete spinal cord injury (SCI).
Hong Kong - RecruitingNCT06455137
Epidural Electrical Stimulation for Spinal Cord Injury Patients and Corticospinal Motor Circuit Improvement
The study aims to examine the plausible interventional mechanisms underlying the effects of epidural spinal cord stimulation.
Taiwan - RecruitingNCT07207798
Epidural Electrical Stimulation in Spinal Cord Injury (T11-L3)
The primary objective of this clinical trial is to investigate the efficacy of Epidural Electrical Stimulation (EES) in restoring motor and sensory function in patients with chronic spinal cord injury (SCI) at levels T11-L3, classified as ASIA B-D.
China - RecruitingNCT05111093
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
The HemON study aims to evaluate the safety and preliminary efficacy of ARC-IM Therapy (Epidural Electrical Stimulation) to improve hemodynamic management and trunk control in people with sub-acute or chronic spinal cord injury (\>= 1 month post injury) between C3 and T6 inclusive, who suffer from…
Switzerland - RecruitingNCT06847295
Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation
Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence. Despite advances in rehabilitation therapies, many individuals with SCI remain unable to stand or walk.
Brazil - RecruitingNCT07722130
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure. Participants receive ESCES plus standard care; electrodes are implanted at C3-C5 with daily individualized stimulation.
China - RecruitingNCT07306052
Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury
The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) combined with rehabilitation training for the reconstruction of walking in patients with chronic spinal cord injury (SCI) classified as AIS B-D.
China - RecruitingNCT03026816
Epidural Stimulation After Neurologic Damage
This study will evaluate a method to optimize parameter settings in epidural spinal cord stimulation used to recover lower extremity volitional movement.
1 US site · Minnesota - RecruitingNCT05705453
Epidural Stimulation After Neurologic Damage: Long-Term Outcomes
This study will evaluate the long-term effect of chronic spinal cord stimulation to restore volitional movement for patients with chronic spinal cord injuries.
1 US site · Minnesota - RecruitingNCT04782947
Epidural Stimulation and Resistance Training After SCI
Spinal cord injury (SCI) is a devastating health problem for tens of thousands of military personnel, Veterans and civilians annually. Many persons with SCI must use a wheelchair for their entire life.
1 US site · Virginia - Not yet recruitingNCT06437548
Epidural Stimulation for Upper Extremity Function
Restoring upper extremity function in patients with cervical spinal cord injury is extremely important for patients' independence and quality of life. At present, there are limited options for hand or arm reanimation in this patient population.
- Enrolling by invitationNCT05966896
Epidural Stimulation to Restore Voluntary Movement Following Spinal Cord Injury
This proof-of-concept case series will prospectively use magnetic resonance imaging (MRI) evidence of spared spinal cord neural fibers to guide the selection of 2 research participants to receive a surgically implanted epidural stimulator with the goal of restoring voluntary movement after spinal…
1 US site · Colorado - RecruitingNCT00623389
Evaluation of an Advanced Lower Extremity Neuroprostheses
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate exercise, standing, stepping and/or balance in people with various degrees of paralysis.
2 US sites · Ohio - RecruitingNCT07722429
Exploration of the Effectiveness and Mechanism of Personalized Epidural Electrical Stimulation in Improving Upper Limb Function in Participants With Spinal Cord Injury
This study aimed to determine whether cervical spinal cord epidural electrical stimulation (EES) can activate upper-limb muscles in individuals with spinal cord injury.
Taiwan - RecruitingNCT06213012
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI).
1 US site · Texas - RecruitingNCT06965127
Implant for Walking After Incomplete SCI
This is a device study that will evaluate the effect of an implanted stimulator on improving walking in people with incomplete spinal cord injury.
1 US site · Ohio - RecruitingNCT06650202
Improving Balance After Spinal Cord Injury Using a Robotic Upright Stand Trainer and Spinal Cord Epidural Stimulation
The purpose of this study is to understand how standing and sitting balance control is altered after spinal cord injury and how a new type of robotic assistive device may be used with spinal stimulation to improve muscle function.
1 US site · New Jersey - RecruitingNCT06515223
Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury
The investigators will recruit up to 20 volunteers with chronic, supra-sacral SCI. Following screening, eligible participants will enter 'Phase I', they will complete baseline outcome measures and then have the epidural spinal cord stimulator (eSCS) implanted with either percutaneous or paddle…
United Kingdom - RecruitingNCT04879862
Locomotor and Bladder Function in Individuals With Acute Spinal Cord Injury
The loss of movement and walking ability significantly affects quality of life after spinal cord injury. In addition, bladder dysfunction consistently ranks as one of the top disorders affecting quality of life after spinal cord injury.
1 US site · New Jersey - Enrolling by invitationNCT07042815
Long-term Follow-up for Epidural Stimulation in SCI
The goal of this study is to understand long-term effects of spinal cord stimulation in individuals who have a spinal cord injury. The main aims are to: 1.
1 US site · New Jersey - Not yet recruitingNCT06077071
Miami "RADAR" Trial
The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by pressure (compressed).
1 US site · Florida - RecruitingNCT07732972
Multilevel Multimodal Neurophysiological Integration for Investigating the Network Modulatory Mechanisms of Epidural Spinal Cord Stimulation
This study will examine how the brain, spinal cord, and muscles communicate in people with spinal cord injury. Researchers will use noninvasive brain and muscle recordings together with spinal electrical recordings to better understand how epidural spinal cord stimulation (EES) affects nerve…
Taiwan - RecruitingNCT04883463
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
This is a phase 1 study of safety and feasibility of cervical spinal cord stimulator implantation in cervical SCI subjects who are ventilator dependent. The Investigators will be focusing on the safety and feasibility of this approach.
2 US sites · California - RecruitingNCT07801274
Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases
This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases. Spinal metastases can press on the spinal cord and cause pain, weakness, or paralysis.
China - Not yet recruitingNCT07527728
Postoperative Neurological Recovery and Risk Factor Analysis in Patients With Paralysis Due to Spinal Metastases
Metastatic spinal tumors represent a common and devastating complication in patients with advanced solid malignancies. Up to 40% of cancer patients may develop spinal metastases during the course of their disease, often resulting in intractable pain, neurological deficits, and spinal instability.
- RecruitingNCT05644171
RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation
Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients.
Singapore - Not yet recruitingNCT07412808
Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study
Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI).
Italy - RecruitingNCT05178056
Spinal Cord Stimulation and Respiration After Injury
Respiratory motor control deficit is the leading cause of morbidity and mortality in patients with spinal cord injury. The long-term goal of this NIH-funded study is to develop a rehabilitation strategy for respiration in patients with spinal cord injury as a standard of care.
1 US site · Kentucky - Not yet recruitingNCT06438991
Spinal Cord Stimulation for Lower Extremity Function
This prospective clinical study will investigate the ability of different spine imaging characteristics to predict ambulation recovery responsiveness using epidural spinal cord stimulator (SCS) in patients with chronic incomplete spinal cord injury (SCI).
- RecruitingNCT07222046
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence.
1 US site · California - RecruitingNCT06867809
Spine and Brain Stimulation for Movement Recovery After Cervical Spinal Cord Injury
Stimulation of the spinal cord and brain represents a new experimental therapy that may have potential to restore movement after spinal cord injury.
2 US sites · New York - RecruitingNCT06845904
Study on Preliminary Safety and Efficacy of Epidural Electrical Stimulation to Manage Lower Urinary Tract Dysfunction After Spinal Cord Injury
This clinical trial aims to assess the preliminary safety and efficacy of Epidural Electrical Stimulation (EES) therapy in managing lower urinary tract dysfunction in individuals with sub-acute or chronic spinal cord injury (SCI).
Switzerland - RecruitingNCT05942339
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)
The purpose of this pre-market clinical study is to assess the preliminary safety and efficacy of the ARC Therapy using the ARC-IM Lumbar System at supporting mobility in participants who have previously received a spinal array and an implantable pulse generator (IPG) either through the STIMO…
Switzerland - RecruitingNCT06701422
Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery
The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial.
2 US sites · New York - Not yet recruitingNCT07745686
VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury
The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce reliance on laboratory-based equipment during rehabilitation in…
Switzerland
Running, but closed to new participants (6)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT06243952
Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation
The purpose of this clinical study is to evaluate the preliminary safety and effectiveness of using a cortical recording device (ECoG) combined with lumbar targeted epidural electrical stimulation (EES) of the spinal cord to restore voluntary motor functions of lower limbs in participants with…
Switzerland - Active, not recruitingNCT04632290
Brain-controlled Spinal Cord Stimulation in Patients With Spinal Cord Injury
In a current first-in-human study, called Stimulation Movement Overground (STIMO, NCT02936453), Epidural Electrical Stimulation (EES) of the spinal cord is applied to enable individuals with chronic severe spinal cord injury (SCI) to complete intensive locomotor neurorehabilitation training.
Switzerland - Active, not recruitingNCT06971510
Exoskeleton Training on Balance Control and Turning in Ambulation in Individuals With Incomplete Spinal Cord Injury
This study investigates the impact of exoskeleton training on individuals with incomplete spinal cord injury (iSCI). Investigators focus on assessing how the use of the exoskeleton influences balance control and turning during ambulation and quality of life in this population.
China - Active, not recruitingNCT02313194
Spinal Cord Neuromodulation for Spinal Cord Injury
This study is designed to assess the strategy of using spinal cord stimulation to improve the ability to move in spinal cord injured humans.
1 US site · California - Active, not recruitingNCT04894734
Spinal Cord Stimulation (SCS) for Spinal Cord Injury (SCI)
The purpose of this feasibility study is to compare the impact of Spinal cord stimulation \[SCS\] for Spinal Cord Injury (SCI) pain and rehabilitation. SCS, also known as Epidural Electrical Stimulation (EES), will be utilized along with conventional medical management (CMM) or CMM alone.
1 US site · North Carolina - Active, not recruitingNCT04123847
Standing, Stepping and Voluntary Movement Spinal Cord Epidural Stimulation
This study will determine the level of functional gain, below the injury for voluntary control of movements, and recovery standing and stepping function as a result of activation of spinal circuits with scES in humans with severe paralysis.
1 US site · Kentucky
Completed and closed (29)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Unknown NCT05941819 ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury
- Completed NCT04052776 Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES
- Terminated NCT03815721 Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity
- Withdrawn NCT04043715 Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function
- Completed NCT03643770 Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
- Completed NCT02339233 Epi Stim to Facilitate Standing and Stepping
- Unknown NCT04105296 Epidural Stimulation After Spinal Cord Injury
- Completed NCT07717606 Epidural Stimulation and Rehabilitation for Spinal Cord Injury
- Unknown NCT05690074 Epidural Stimulation in Chronic Spinal Cord Injury Patients
- Completed NCT04736849 Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
- Unknown NCT03966794 Functional Scaffold Transplantation Combined With Epidural Electrical Stimulation for Spinal Cord Injury Repair
- Unknown NCT03949660 Improving Bowel Function and Quality of Life After Spinal Cord Injury
- Completed NCT04302259 Intelligent Spine Interface, Clinical (ISI-C)
- Completed NCT04241250 Neuromodulation Techniques After SCI
- Terminated NCT03655080 Pulsed Abraxane and Radiotherapy for Improving and Maintaining Ambulation After Cancer-Related Cord Compression
- Completed NCT04193709 Recovery of Bladder and Sexual Function After Human Spinal Cord Injury
- Completed NCT03036527 Recovery of Bladder and Sexual Function After Spinal Cord Injury
- Completed NCT02037620 Recovery of Cardiovascular Function With Epidural Stimulation After Human Spinal Cord Injury
- Completed NCT04237363 Recovery of Walking in Persons With Complete Spinal Cord Injury
- Withdrawn NCT02899858 Restoration of Standing and Walking With ISMS in Humans
- Terminated NCT04994886 Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
- Unknown NCT05044923 Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
- Completed NCT02936453 STIMO: Epidural Electrical Simulation (EES) With Robot-assisted Rehabilitation in Patients With Spinal Cord Injury.
- Completed NCT05095454 Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
- Completed NCT02592668 Spinal Cord Injury Epidural Stimulation
- Completed NCT05926843 Spinal Cord Stimulation Assisted by Motor Rehabilitation Training for Restoring Motor Function After Spinal Cord Injury
- Completed NCT05433064 Spinal Cord Stimulation for Spinal Cord Injury Patients - Regain Walk and Alleviate Pain
- Unknown NCT01826058 Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression
- Unknown NCT03364660 Task-specific Epidural Stimulation Study
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".