Surgical Procedure Clinical Trials for Spinal Cord Injury
SCI.help tracks 103 spinal cord injury clinical trials studying surgical procedure, and 23 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.
Open these in the Trials Finder → Add a target (walking, bladder, pain…), a state, or a status filter.
Other treatment categories
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Browse by state
- New York (161)
- Florida (139)
- Texas (119)
- California (116)
- Illinois (105)
- Pennsylvania (92)
- New Jersey (91)
- Ohio (83)
- Georgia (59)
- Massachusetts (59)
- Minnesota (55)
- Colorado (49)
- Michigan (48)
- Maryland (48)
- Washington (46)
- Kentucky (43)
- Virginia (41)
- Missouri (41)
- North Carolina (32)
- Alabama (32)
Open and recruiting (23)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- RecruitingNCT06097000
A Study of the Safety and Efficacy of Intelligent Powered Exoskeletons in Postoperative Spinal Rehabilitation
Systematic and professional rehabilitation training is generally effective for patients with lower limb dyskinesia, but most of them lose the chance of recovery due to failure to receive systematic rehabilitation treatment.
China - RecruitingNCT03023696
Can Prophylactic Foraminotomy Prevent C5 Palsy
C5 palsy (C5P) is a well-known, although rare complication of cervical spine decompression surgery. In severe forms, C5P causes debilitating upper extremity weakness involving the deltoids and/or biceps brachii muscles, ultimately diminishing these patients' quality of life.
1 US site · Ohio - RecruitingNCT06293157
Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease
Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located.
Poland - RecruitingNCT04623593
Cervical Arthroplasty Cost Effectiveness Study (CACES)
To date, no consensus exists on which anterior surgical technique is more cost-effective to treat cervical degenerative disc disease (CDDD). The most commonly used surgical treatment for patients with single- or multilevel symptomatic CDDD is anterior cervical discectomy with fusion (ACDF).
Netherlands - RecruitingNCT06654804
Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury
Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury.
1 US site · Washington - RecruitingNCT07583836
DELAYED VERSUS EARLY SURGICAL DECOMPRESSION FOR TRAUMATIC SPINAL CORD INJURY
To compare the outcome of early versus delayed surgical decompression among patients presenting with traumatic spinal cord injury in a tertiary care hospital.
Pakistan - Enrolling by invitationNCT07280351
Duraplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn if a procedure called "expansile duraplasty" can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI).
1 US site · California - RecruitingNCT04855838
Dysphagia After Anterior Cervical Spine Surgery
The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3 months later.
Sweden - Not yet recruitingNCT07733401
Guided Laminectomy With Augmented Duroplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn whether expansile duraplasty can improve neurological recovery in adult patients with acute severe traumatic spinal cord injury, as well as evaluate the safety of this surgical strategy. The main questions the study aims to answer are: 1.
China - RecruitingNCT05163899
Investigation of Surgical Sectioning of the Filum Terminale in Treating Occult Tethered Cord Syndrome Patients
The investigators hypothesize that surgical release of the filum terminale (strand of fibrous tissue at the end of the spinal cord) is a more efficacious treatment option for symptomatic relief than medical management in subjects with Occult Tethered Cord Syndrome (OTCS) and that the risks do not…
1 US site · New York - Not yet recruitingNCT06077071
Miami "RADAR" Trial
The purpose of this study is to see if treating cancer with radiation therapy administered by the Varian Ethos system can control patient's tumor and eliminate the need for surgery used to treat nerves in the spine flattened by pressure (compressed).
1 US site · Florida - RecruitingNCT07541612
NIRS MONITORING OF SPINAL CORD ISCHEMIA IN AORTIC SURGERY
This prospective observational study aims to evaluate the feasibility and clinical utility of near-infrared spectroscopy (NIRS) monitoring applied to paraspinal muscles as a surrogate marker of spinal cord perfusion in patients undergoing major noncardiac surgery.
Italy - RecruitingNCT07801274
Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases
This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases. Spinal metastases can press on the spinal cord and cause pain, weakness, or paralysis.
China - Not yet recruitingNCT07527728
Postoperative Neurological Recovery and Risk Factor Analysis in Patients With Paralysis Due to Spinal Metastases
Metastatic spinal tumors represent a common and devastating complication in patients with advanced solid malignancies. Up to 40% of cancer patients may develop spinal metastases during the course of their disease, often resulting in intractable pain, neurological deficits, and spinal instability.
- Not yet recruitingNCT07798310
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury III (PROMPT-SCI III) Trial
This longitudinal cohort study will investigate the clinical benefits of early acute exercise therapy after mild spinal cord injury (SCI).
Canada - RecruitingNCT05786313
Study of Individualized, Precise and Standardized Cervical Open-door Surgery for Cervical Spinal Stenosis
To evaluate the safety and effectiveness of individualized, precise and standardized open-door posterior cervical surgery through a single-center, exploratory clinical study, so as to provide a more reliable basis for the treatment of cervical spinal stenosis.
China - RecruitingNCT07090057
The Effect of Targeting the Plantaris Muscle-tendon in Surgical Correction of Ankle Equinus in Children
Tight ankle muscles can produce ankle equinus (limited ability to pull the foot upward) and occur often in children, significantly impacting their ability to walk. If not treated, children with ankle equinus frequently experience reduced function and long-term foot problems, such as pain.
Canada - RecruitingNCT07636135
Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy
The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical spine surgery.
Canada - Not yet recruitingNCT07253233
Treatment of Spinal Cord Injury Using Autologous Concentrated Growth Factors
Spinal cord injury (SCI) is a severe disorder of the central nervous system, and effective clinical management remains a significant global challenge.
- RecruitingNCT07750808
ZEPU AI9 Exoskeleton Rehabilitation Robot
The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic surgery.
Bangladesh - RecruitingNCT07749625
ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)
The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems.
Bangladesh - RecruitingNCT07735676
ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)
Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence.
Bangladesh - RecruitingNCT07735702
ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)
The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to stroke, incomplete spinal cord injury, or persistent gait impairment…
Bangladesh
Running, but closed to new participants (5)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT07792616
Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity
Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain.
2 US sites · Mississippi - Active, not recruitingNCT05653206
Incomplete Cervical SCI Without Instability
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of administering a set of additional core and optional outcome assessments in…
10 US sites · California, Maryland, Wisconsin - Active, not recruitingNCT07488702
Intradurale Spinal Tumors: Management and Treatment
Intradurale spinal tumors are rare neoplastic lesions that involve the spinal cord and surrounding structures and may cause neurological symptoms such as pain, motor deficits, sensory disturbances, and sphincter dysfunction.
Italy - Active, not recruitingNCT04189172
MiDura-Study (Neuro-Patch in Duraplasty)
The aim of this study is to collect systematically and proactively data regarding the performance of Neuro-Patch, like complications and handling, under daily clinical practice when used as intended by the manufacturer
France, Germany - Active, not recruitingNCT07594574
Posterior Minimally Invasive Surgery for Treating Paralytic Scoliosis With Pelvic Obliquity in Children Following Spinal Cord Injury
This randomized controlled trial compares posterior minimally invasive correction surgery with conventional posterior spinal fusion for children with paralytic scoliosis and severe pelvic obliquity following spinal cord injury.
China
Completed and closed (75)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Suspended NCT03229031 A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Safety and Efficacy of ES135 in Subjects With Spinal Cord Injury
- Completed NCT02527304 Adaptive Staged Stereotactic Body Radiation Therapy in Treating Patients With Spinal Metastases That Cannot Be Removed by Surgery
- Completed NCT01683916 Anesthetic Requirement and Stress Hormone Response During Surgery in Spinal Cord-injured Patients
- Completed NCT02482194 Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study
- Terminated NCT01407341 Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer
- Withdrawn NCT00262496 Botulinum-A Toxin Injection for Detrusor Hyperreflexia in Spinal Cord Injury: A Non-Surgical Approach.
- Completed NCT02564419 Brain Machine Interface (BMI) in Subjects Living With Quadriplegia
- Completed NCT05530798 CEUS For Intraoperative Spinal Cord Injury
- Unknown NCT01470950 Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy
- Completed NCT00778323 Clinical Trial of Remote Preconditioning in Patients Undergoing Cervical Decompression Surgery
- Unknown NCT02870426 Collection and Characterisation of Human Olfactory Ensheathing Cells
- Completed NCT02006901 Comparative Effectiveness of Microdecompression and Laminectomy for Central Lumbar Spinal Stenosis
- Completed NCT01204736 Comparing Outcomes of Elbow Extension Tendon Transfers
- Terminated NCT01367405 Comparing Surgical Decompression Versus Conservative Treatment in Incomplete Spinal Cord Injury
- Terminated NCT03114345 Correlation Between Pressure Differences and Micro-vascularization Changes in Bedridden Paraplegic Patient
- Completed NCT02016768 Decompressive Cervical Surgery and Hypertension
- Completed NCT01932905 Deep rTMS in Central Neuropathic Pain Syndromes
- Completed NCT02942953 Diaphragmatic Pacer Placement: Anesthetic Management (DP)
- Completed NCT03296592 Diffusion MRI in Cervical Spondylotic Myelopathy (CSM)
- Completed NCT04034108 Early Surgical Intervention Combined With Weight-supported Walking Training
- Completed NCT03643770 Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
- Completed NCT05591001 Effects of Anesthetic Infusion on the Amplitude of Motor Evoked Potential in Pediatrics Undergoing Tethered Spinal Cord Surgeries
- Completed NCT04936217 Efficacy and Safety of a Continent Cutaneous Urinary Diversion in Spinal Cord Injury Patients
- Terminated NCT03513783 Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation
- Completed NCT00047619 Enhancement of Pressure Healing With Pulsatile Lavage
- Unknown NCT03320759 Enhancing Recovery in Non-Traumatic Spinal Cord Injury
- Completed NCT04925882 Erector Spinae Plane Block in Lumbar Release Surgery
- Unknown NCT05910593 Establishing the Validity and Reliability of a Dexterity Assessment Tool
- Terminated NCT00786968 Extension Study of Intrathecal Enzyme Replacement Therapy for MPS I
- Terminated NCT03048331 Functional Electrical Stimulation (FES) and Reconstructive Tetraplegia Hand and Arm Surgery
- Completed NCT03112941 Hyperbaric Oxygen and Orthopedic Comprehensive Treatment for Traumatic Incomplete Spinal Cord Injury in the Plateau
- Terminated NCT03101982 Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury. (EOS) - Pilot Study
- Completed NCT01637766 Intra-arterial Chemotherapy for Spinal Metastases
- Completed NCT03910101 Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity Treatment
- Completed NCT00221767 Medico-economical Impact of the Brindley Neurosurgical Technique in France
- Unknown NCT02934594 Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate
- Terminated NCT02034461 Micro-Electrodes Implanted in a Human Nerve
- Unknown NCT03632005 Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
- Completed NCT01714349 Nerve Transfer After Spinal Cord Injuries
- Completed NCT06596629 Nerve Transfers for Restoration of Hand Function in Cervical Spinal Cord Injury: Effects and Influencing Factors
- Withdrawn NCT02861612 Nerve Transfers to Restore Hand Function in Spinal Cord Injury
- Completed NCT02768103 Neural Adaptation After Tendon Transfer and Training in Tetraplegia
- Completed NCT03414424 Non-invasive Cervical Electrical Stimulation for SCI
- Completed NCT01485458 Optimal Treatment for Spinal Cord Injury Associated With Cervical Canal Stenosis (OSCIS) Study
- Completed NCT02616081 Patient Reported Outcomes for Bladder Management Strategies in Spinal Cord Injury
- Completed NCT01355549 Platelet-Rich Plasma Therapy for Shoulder Pain in Persons With Spinal Cord Injury
- Terminated NCT00105859 Preventing Pressure Ulcers in Veterans With Spinal Cord Injury (SCI)
- Completed NCT04699474 Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury
- Terminated NCT02412046 Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics
- Terminated NCT03451474 Restoring Hand Function Utilizing Nerve Transfers in Persons With Cervical Spinal Cord Injuries
- Terminated NCT04994886 Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
- Completed NCT04315389 SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study
- Completed NCT01186679 Safety and Efficacy of Autologous Bone Marrow Stem Cells in Treating Spinal Cord Injury
- Completed NCT05601661 Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury
- Withdrawn NCT06347575 Safety and Tolerability of a Novel Implantable Neurostimulator for Ameliorate Erectile Function on Spinal Cord Injured Patients
- Completed NCT01184365 Spinal Cord Injury Energy Management Program
- Completed NCT03702010 Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
- Unknown NCT01826058 Spine Stereotactic Body Radiation Therapy for Metastatic Epidural Spinal Cord Compression
- Unknown NCT03529708 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression
- Terminated NCT02167633 Stereotactic Radiosurgery in Metastatic Spinal Cord Compression
- Terminated NCT03762655 Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
- Completed NCT00004445 Study of an Implantable Functional Neuromuscular Stimulation System for Patients With Spinal Cord Injuries
- Completed NCT03464409 Supporting Patient Decisions About UE Surgery in Cervical SCI
- Unknown NCT00475748 Surgical Management of Spinal Cord Injuries In Neck
- Completed NCT01865942 Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery
- Completed NCT01674764 Surgical Treatment for Spinal Cord Injury
- Completed NCT04995796 Testing the Decision Aid: Supporting Patient Decisions About Upper Extremity Surgery in Cervical SCI
- Unknown NCT02034669 Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment
- Unknown NCT02663310 Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs Rehabilitation
- Completed NCT02926391 UNiD 3D VBR Register
- Completed NCT01899664 Upper Extremity Surgery in Spinal Cord Injury
- Completed NCT04483570 Urological Deterioration in Secondary Tethered Cord Syndrome and Clue to Detect It
- Completed NCT03220451 Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients
- Completed NCT00458354 Use of Spinal Sealant System During Spinal Surgery
- Completed NCT04056988 tSCI Contrast Enhanced Ultrasound Study
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".