Rehabilitation Clinical Trials for Spinal Cord Injury
SCI.help tracks 568 spinal cord injury clinical trials studying rehabilitation, and 121 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.
Open these in the Trials Finder → Add a target (walking, bladder, pain…), a state, or a status filter.
Other treatment categories
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Browse by state
- New York (161)
- Florida (139)
- Texas (119)
- California (116)
- Illinois (105)
- Pennsylvania (92)
- New Jersey (91)
- Ohio (83)
- Georgia (59)
- Massachusetts (59)
- Minnesota (55)
- Colorado (49)
- Michigan (48)
- Maryland (48)
- Washington (46)
- Kentucky (43)
- Virginia (41)
- Missouri (41)
- North Carolina (32)
- Alabama (32)
Open and recruiting (121)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- RecruitingNCT06494059
A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients
The purpose of this research is to explore the effect of magnetic stimulation to activate the brain, electrical spinal cord stimulation to activate spinal cord, and electrical muscle stimulation used to activate upper limb (arms), lower limb (legs) and trunk (stomach) muscles in people with spinal…
1 US site · Florida - RecruitingNCT06097000
A Study of the Safety and Efficacy of Intelligent Powered Exoskeletons in Postoperative Spinal Rehabilitation
Systematic and professional rehabilitation training is generally effective for patients with lower limb dyskinesia, but most of them lose the chance of recovery due to failure to receive systematic rehabilitation treatment.
China - RecruitingNCT07036107
A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the Spanish Healthcare System
This clinical trial aims to collect evidence on the clinical benefits and the socioeconomic impact of integrating a novel wearable powered lower-limb exoskeleton for gait rehabilitation in acute/subacute spinal cord injured individuals and to evaluate the efficiency of this technology to the…
Spain - Not yet recruitingNCT07452133
AI-Powered Closed-Loop Multielectrode Transcutaneous Spinal Cord Stimulation: Real-Time Adjustments for Enhanced Motor Recovery in Spinal Cord Injury (AIM RECOVER)
Spinal cord injury (SCI) often results in persistent motor deficits that are inadequately addressed by conventional rehabilitation.
Singapore - Not yet recruitingNCT07626931
Abdominal Stimulation to Improve Cough After Spinal Cord Injury
The goal of this clinical trial is to learn if abdominal functional electrical stimulation (FES) using the VentFree Respiratory Muscle Stimulator improves cough strength in adults with a new spinal cord injury (SCI). It will also learn about the safety of abdominal FES in this population.
- RecruitingNCT06472986
Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)
The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.
Canada - RecruitingNCT06538974
Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult Population
In 2019, approximately 2.4 billion people worldwide required rehabilitation for various health pathologies, a 63% increase since 1990.
France - RecruitingNCT05615766
Assessment of a Robotic Exoskeleton for Upper Limb Rehabilitation
Rehabilitation robotics has the potential to facilitate rehabilitation at home and empower people with spinal injuries to self-manage increasing their independence and improving their quality of life.
United Kingdom - RecruitingNCT04496609
Assessment of the Efficacy and Safety of EESS in Patients With Incomplete Spinal Cord Injuries
Neurological disability caused by traumatic lesions of the spinal cord is a significant challenge for medicine and society. These lesions, leading to sublesional central nervous system dysfunction, include sensorimotor, vesico-sphincter and genito-sexual disorders.
France - RecruitingNCT06293157
Carbon Fiber Transpedicular Screws in Treatment of Spinal Metastatic Disease
Background: Spinal metastatic disease constitute a serious clinical problem in oncology. Bones are the third most common organ where metastases are located, and the spine is the place where they are most often located.
Poland - Not yet recruitingNCT07725952
Cardiovascular Autonomic Function After Resistance Training
The purpose of this clinical trial is to evaluate whether an 8-week upper-limb resistance training program improves cardiovascular autonomic function in adults with chronic spinal cord injury (SCI).
South Korea - RecruitingNCT07745712
Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting
The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program in a clinical setting.
Spain - Not yet recruitingNCT07689227
Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)
The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in individuals with mobility impairments resulting from chronic, incomplete spinal…
4 US sites · Massachusetts, Texas - RecruitingNCT07139496
Combined Injury-site & Lumbosacral Epidural Spinal Cord Stimulation
Spinal cord stimulation (SCS) has been shown in previous studies to be capable of restoring motor and autonomic function in patients with chronic complete spinal cord injury (SCI).
Hong Kong - Not yet recruitingNCT05217498
Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury
Breathing brief, moderate bouts of low oxygen trigger (low oxygen therapy, LOT) spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new experiences), and improve walking after spinal cord injury (SCI).
1 US site · Massachusetts - RecruitingNCT06773286
Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury
The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training (ABT) and spinal cord transcutaneous stimulation (scTS) can improve…
1 US site · New Jersey - RecruitingNCT06828653
Comparing Digitally and Traditionally Made Ankle Foot Orthoses
The research is being done to compare two methods of creating AFOs: 1. The traditional method, which involves manually creating a mold from a plaster cast of the client's limb. This is time-consuming and labor-intensive; and 2.
Canada - RecruitingNCT07237386
Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations
Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment.
Belgium - Not yet recruitingNCT07015099
Complications Associated With Delayed Admission to Spinal Injury Unit
The aim of this study is to determine the prevalence of complications including PUs at time of admission to a regional spinal injury rehabilitation unit (MCSI), the relationship between wait time to admission for specialist SCI rehabilitation and complication n occurrence, neurological recovery,…
United Kingdom - RecruitingNCT05906056
Continuous Passive Motion Versus Heterotopic Ossification
The investigators hypothesize that Heterotopic Ossification (HO) formation can be suppressed if the application of a Continuous Passive Motion (CPM) device can be performed for a substantial amount of time.
Greece - Not yet recruitingNCT07794072
Digital Patient Engagement in Technology-Supported Neurorehabilitation
The goal of this observational study is to investigate digital patient engagement and its psychosocial correlates and potential predictors among adults aged 18-85 years with neurological disorders who are undergoing technology-supported neurorehabilitation using robotic systems for upper-limb…
Italy - Not yet recruitingNCT07619300
Dorsal Root Ganglion Stimulation After Lower Motor Neuron Damage
The purpose of this study is to study sensorimotor circuit activity generated in response to temporarily implanted dorsal root ganglion stimulation by recording from muscles of the lower extremities as well as functional outcomes achieved over a 10-day rehabilitation program in an individual with…
1 US site · Minnesota - RecruitingNCT06853015
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
1 US site · Illinois - Not yet recruitingNCT05784285
Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities
Participation in community-based activities is essential to the health and well-being of youth with physical disabilities; yet, it is extremely restricted.
Canada - RecruitingNCT04855838
Dysphagia After Anterior Cervical Spine Surgery
The purpose of this research project is to investigate the incidence of impaired swallowing (dysphagia) after anterior cervical spine surgery (ACSS) and to study the long-term effect of dysphagia on nutritional status 12 ± 3 months later.
Sweden - RecruitingNCT07705256
EMG-Directed Virtual-Reality Training for Motor Stroke Rehabilitation
This study is testing whether rehabilitation using muscle activity signals can help improve arm and hand movement in people after stroke or spinal cord injury. In the main study, participants will use a virtual-reality feedback system that is controlled by surface electromyography (EMG).
United Kingdom - RecruitingNCT05337982
Eccentric Muscle Training, Stimulation, and Biomarkers in SCI
The investigators are studying a new rehabilitation treatment for individuals trying to recover walking after spinal cord injury (SCI). The investigators will test conditions in the blood and spinal fluid to determine the best time to start this new training program.
2 US sites · Ohio - Not yet recruitingNCT07653529
Effect of Antigravity Treadmill Training on Cardiorespiratory Fitness and Lower Limb Function in Incomplete Spinal Cord Injury
This study aims to investigate the effect of locomotor training using an antigravity treadmill on cardiorespiratory fitness and lower limb function in patients with incomplete spinal cord injury.
- RecruitingNCT07263581
Effect of Hybrid Functional Electrical Stimulation and Augmented Reality-Based Gait Training on Gait Parameters Among Incomplete Spinal Cord Injury Patients
The goal of this clinical trial is to determine whether combining Functional Electrical Stimulation (FES) with Augmented Reality (AR)-based gait training can improve walking ability in individuals with incomplete spinal cord injury (SCI).
Pakistan - RecruitingNCT07050069
Effect of Threshold Pressure-Loaded RMT + tTBS on Respiratory Function in SCI Patients
The purpose of this clinical trial is to understand whether threshold pressure load respiratory muscle training combined with iTBS can effectively improve the respiratory function of SCI patients.
China - RecruitingNCT06089915
Effectiveness of Robot-assisted Upper-limb Exercise in Cervical SCI
The aim of the project is to test the effectiveness of robot-assisted upper-limb exercise in persons after cervical spinal cord injury. In a randomised controlled two-arm trial, the effect of adding two types of robot-assisted upper-limb exercise to standard occupational therapy will be tested.
Slovenia - RecruitingNCT05142943
Effectiveness of Virtual Bodily Illusion Intervention in Upper Limb Motor Function in People With Incomplete Spinal Cord Injury.
Previous studies have shown that the neuroplasticity of the residual corticospinal fibers, the motor cortex and the spinal neurons plays an important role in the spontaneous functional recovery of people with neurological or musculoskeletal pathology.
Spain - RecruitingNCT04520178
Effects of 5HTP on the Injured Human Spinal Cord
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity.
2 US sites · Kentucky - RecruitingNCT06876285
Effects of Wheelchair Treadmill and Conventional Exercises on Trunk Balance in Spinal Cord Injury Patients
This study aims to determine whether wheelchair treadmill exercises improve trunk balance and stability compared to conventional wheelchair exercises. Trunk balance is essential for mobility, transfers, and daily activities in individuals with spinal cord injury (SCI).
Turkey (Türkiye) - Enrolling by invitationNCT07732868
Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury
Spinal cord injury (SCI) is a highly debilitating pathology, associated with the loss of sensorimotor functions, autonomy and quality of life. Although there is currently no cure, brain-machine interfaces (BMI) have been used as a method of SCI rehabilitation.
Portugal - Not yet recruitingNCT06099340
Effects of an Eccentric Muscle Strengthening Protocol on Force Moment, Muscle Activation and Plantar Flexor Structure of Patients With Central Nervous System Injuries.
Neurological disorders \[such as Cerebral Vascular Accident (CVA) or Spinal Cord Injury (SCI)\] are among the most costly health problems to society in industrialized countries. For those affected, they generate severe restrictions in mobility, significantly altering their quality of life.
France - RecruitingNCT07768761
Electrical Stimulation Exercise for Individuals With Lower Limb Paralysis
The purpose of this research study is to evaluate the effectiveness of an exercise training intervention (24-36 sessions) to improve muscle strength and endurance in the lower limbs of individuals with paralysis.
1 US site · Ohio - RecruitingNCT07364773
Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing
The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI/D) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are trained in a counseling style called motivational interviewing.
3 US sites · Illinois, Texas, Washington - RecruitingNCT07207798
Epidural Electrical Stimulation in Spinal Cord Injury (T11-L3)
The primary objective of this clinical trial is to investigate the efficacy of Epidural Electrical Stimulation (EES) in restoring motor and sensory function in patients with chronic spinal cord injury (SCI) at levels T11-L3, classified as ASIA B-D.
China - RecruitingNCT07306052
Epidural Spinal Cord Stimulation for Restoring Walking in Spinal Cord Injury
The goal of this clinical trial is to evaluate the safety and effectiveness of Epidural Electrical Stimulation (EES) combined with rehabilitation training for the reconstruction of walking in patients with chronic spinal cord injury (SCI) classified as AIS B-D.
China - Not yet recruitingNCT07616050
Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients
The purpose of this clinical study is to evaluate the feasibility, usability, and motivational impact of VirtualPark, a virtual reality-based dual-task rehabilitation system, in adults with neurological and age-related conditions.
Italy - Enrolling by invitationNCT06906536
Examining the Effect of Acute Intermittent Hypoxia on Serum Blood Proteins and Lower Limb Function
The goal of this study is to clarify mechanisms of acute intermittent hypoxia and to examine the effect on lower limb function in persons with chronic, incomplete spinal cord injury.
1 US site · Colorado - RecruitingNCT06705790
Exploring the Benefits of Pelvic Floor Muscle Training on Bladder, Bowel, and Sexual Function in People With Spinal Cord Injury
The goal of this trial is to learn about the feasibility and benefits of delivering a pelvic floor muscle training program to people with motor-incomplete spinal cord injury. The main questions it aims to answer are: 1.
Canada - RecruitingNCT07519928
Exploring the Feasibility and Benefits of Implementing Pelvic Floor Muscle Training During Inpatient Rehabilitation for People With Spinal Cord Injury
The goal of this clinical study is to determine the feasibility and explore the potential benefits of pelvic floor muscle training during inpatient SCI rehabilitation on urinary, bowel, and sexual function and quality of life in people with SCI. The main questions it aims to answer are: 1.
Canada - RecruitingNCT07588503
FES Cycling With BFR in the Spinal Cord Injury Population
Cardiometabolic Disease (CMD) is the silent killer within the spinal cord injury/disease (SCI/D) population. Many SCI/D patients' initial CMD presentation is with a heart attack, stroke, or sudden cardiac death, highlighting the need for interventions to reduce CMD risk.
Canada - Enrolling by invitationNCT05989906
Feasibility of a Sprint Interval Training Program During Inpatient Spinal Cord Injury Rehabilitation
This study will assess the feasibility and efficacy of 3 treatments to increase physical activity during and after inpatient rehabilitation (IPR) for new spinal cord injuries: 1. Program of sprint interval training (SIT) on an arm crank ergometer during IPR 2.
1 US site · Washington - Not yet recruitingNCT07773974
Functional Electrical Stimulation Plus High Intensity Interval Training at Home
People living with SCI may experience loss of sensation, movement and regular body function. One way to address these impairments is activity-based therapy (ABT), which includes movement-based activities that promote the muscle-brain connection below the level of injury.
Canada - RecruitingNCT06244160
High Flow Oxygen Therapy After Spinal Cord Injury
The goal of this feasibility study is to learn about the ability to use a different form of oxygen therapy (known as high flow oxygen therapy) in patients who have a spinal cord injury in the upper back or neck. The main questions it aims to answer are: 1.
United Kingdom - RecruitingNCT07553923
High-intensity Walking Rehabilitation in Outpatient Subacute Spinal Cord Injury
People with incomplete spinal cord injury (SCI) often have some preserved movement and may regain walking ability, but recovery can be limited, and more effective rehabilitation approaches are needed.The goal of this clinical trial is to learn if high-intensity walking rehabilitation can improve…
Canada - RecruitingNCT02991248
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
1 US site · Illinois - RecruitingNCT05424172
Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching
The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding…
1 US site · Illinois - RecruitingNCT06650202
Improving Balance After Spinal Cord Injury Using a Robotic Upright Stand Trainer and Spinal Cord Epidural Stimulation
The purpose of this study is to understand how standing and sitting balance control is altered after spinal cord injury and how a new type of robotic assistive device may be used with spinal stimulation to improve muscle function.
1 US site · New Jersey - RecruitingNCT06690372
Improving Heart Health in Individuals With SCI Using Home-Based Virtual Gaming
What is the ultimate applicability of the research? Individuals with SCI face several challenges when trying to engage in exercise following injury. Barriers to engagement include cost, transportation, and lack of SCI accessible resources.
1 US site · Pennsylvania - Not yet recruitingNCT07223710
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI.
1 US site · Illinois - RecruitingNCT06920524
Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity (MUSIBOT)
Botulinum toxin (BT) injections are a painful treatment frequently used to treat spasticity following central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma). Tolerance of injections varies from patient to patient.
France - Not yet recruitingNCT07037628
Investigating the Impact of Spinal Cord Electrical Stimulation Combined With Individualized Physical Therapy on Lower Extremity Function in Patients With Spinal Cord Injury
This study aims to understand the differences in the effects of two rehabilitation approaches on lower limb function recovery in patients with spinal cord injuries: 1. Spinal cord stimulation (SCS) combined with one-on-one physical therapy 2. One-on-one physical therapy alone
Taiwan - RecruitingNCT03621254
Investigation Into Optimal FES Training Characteristics After Spinal Cord Injury
The aim of this study is to investigate two different modalities of functional electrical stimulation (FES) leg exercise in patients with spinal cord injury (SCI). The primary outcomes being compared are 1. FES-induced leg aerobic fitness, and 2. FES-induced leg strength.
Switzerland - RecruitingNCT05926596
Leg Stretching Using an Exoskeleton on Demand for People With Spasticity
The purpose of this research study is to develop a protocol using a fully wearable, portable lower-limb exoskeleton for improving leg and walking function in people with movement disorders.
1 US site · New York - RecruitingNCT04460872
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and overground walking) in men with testosterone deficiency and walking…
2 US sites · Florida - RecruitingNCT06521723
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.
2 US sites · Florida, Massachusetts - RecruitingNCT07645027
Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer in Patient With Cervical Spinal Cord Injuries
This randomized clinical trial aims to evaluate the effectiveness of combining Low Volume Nose Resistance Breathing Exercises (LVNRBE) with Incentive Spirometry (IS) on respiratory outcomes in patients with cervical spinal cord injury (SCI).
Pakistan - RecruitingNCT02592291
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to…
1 US site · Pennsylvania - RecruitingNCT07732972
Multilevel Multimodal Neurophysiological Integration for Investigating the Network Modulatory Mechanisms of Epidural Spinal Cord Stimulation
This study will examine how the brain, spinal cord, and muscles communicate in people with spinal cord injury. Researchers will use noninvasive brain and muscle recordings together with spinal electrical recordings to better understand how epidural spinal cord stimulation (EES) affects nerve…
Taiwan - RecruitingNCT07204184
Multisite Transspinal Stimulation for Augmenting Recovery in Spinal Cord Injury
A well-established rehabilitation strategy for improvements of standing and walking ability in persons with spinal cord injury (SCI) is step training on a motorized treadmill with body weight support. A promising intervention is stimulation of the spinal cord through the skin (transspinal).
1 US site · New York - RecruitingNCT05553457
MyHand-SCI: An Active Hand Orthosis for Spinal Cord Injury
The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.
1 US site · New York - RecruitingNCT06817577
NG004 in Spinal Cord Injury Patients
This is the FIH, multicenter, open-label, sequential, multiple ascending dose trial of NG004 in patients with acute incomplete cervical SCI. The trial will evaluate the safety, tolerability, and PK of 4 dose regimens of NG004, and will evaluate the maximum tolerated dose of NG004.
Germany, Switzerland - RecruitingNCT06065384
Neural Plasticity and Motor Recovery After Upper Extremity Motor Training in People With c-SCI
After spinal cord injury (SCI), there is a disruption in neural circuits resulting in paralysis. There is not yet a cure for paralysis.
Belgium, Netherlands - RecruitingNCT05644522
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
1 US site · Illinois - RecruitingNCT06903416
Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial
This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life.
Canada - RecruitingNCT05183152
Non-invasive BCI-controlled Assistive Devices
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…
1 US site · Texas - Not yet recruitingNCT07596563
Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury
This is a randomised, blinded and controlled Phase I trial to measure the safety, feasibility and efficacy of a combined cell transplantation and intensive rehabilitation intervention to treat spinal cord injury.
- RecruitingNCT05094362
Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning
The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure.
2 US sites · South Carolina - Not yet recruitingNCT07099625
Optimization of Adaptive Rowing Seating
Adaptive sports programs are integral components to combating Veteran isolation, promoting wellbeing and seeking to build teams, networks, communities. These activity-based communities are medicine free treatment systems enhancing Veterans' health from a holistic perspective.
2 US sites · Minnesota, Ohio - RecruitingNCT06314594
Personalized Prevention and Treatment Strategies for Adolescent Idiopathic Scoliosis Via a Comprehensive Health Management Platform
Spinal cord injury (SCI), leads to functional deficits and complications like neurogenic bladder and deep vein thrombosis, imposing a global annual financial burden. This trial aims to compares Jiaji electroacupuncture (JEA) and scalp electroacupuncture (SEA) in SCI rehabilitation.
China - RecruitingNCT07674927
Pilot Study Exploring the Effects of Rhythmic Auditory Stimulation on Gait in People With Motor Incomplete Spinal Cord Injury
This pilot study aims to evaluate the feasibility and preliminary efficacy of a wearable rhythmic auditory stimulation system, MedRhythms, for improving gait parameters in patients with motor incomplete SCI. Up to 15 participants aged 18 years or older with non-progressive SCI will be enrolled.
1 US site · California - RecruitingNCT05484557
Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury
Currently, Enoxaparin is the usual prophylactic anticoagulant treatment at the acute and sub-acute phases of spinal cord injury (SCI). Patients at the sub-acute phase of SCI (rehabilitation) will be given either Enoxaparin 40 mg/day (control) or Apixaban 2.5-5 mg twice a day.
Israel - RecruitingNCT06176833
Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury
The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury.
2 US sites · Illinois, Texas - RecruitingNCT07472985
Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial
Spinal cord injuries (SCI) are among the most catastrophic survivable events experienced by human beings. Affected individuals remain with lifelong neurological impairment involving motor, sensory, bladder and bowel functions, which in turn impacts quality of life and independence.
Canada - RecruitingNCT07488793
Remote Ischemic Conditioning for PwSCI
The long-term goal of this project is to improve the overall cardiometabolic health of persons with spinal cord injury (SCI).
1 US site · Missouri - RecruitingNCT04967274
Reticulospinal Control of Movements
Accurate movement execution is a result of a complex interplay between various muscle groups whose activity is controlled by different areas of the central nervous system.
Switzerland - RecruitingNCT06775925
Robot-assisted vs. Conventional Occupational Therapy of the Upper Limb in Individuals With Cervical Spinal Cord Injury
The goal of this clinical trial is to learn the effects of robot-assisted therapy using the ArmeoSpring on upper limb function compared to conventional occupational therpay in individuals with cervical spinal cord injury (cSCI).
Switzerland - RecruitingNCT06677905
SCI&U Peer Health Coaching Program for Individuals Newly Discharged From Inpatient Rehabilitation
The goal of this clinical trial is to learn if the online program and web-based platform for delivery of self-management services to people with spinal cord injury (SCI) called "SCI \& U" can support transitions from hospital to the community after injury.
2 US sites · Connecticut - RecruitingNCT07404761
Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments
This is a multicenter, randomized, controlled clinical study evaluating the safety and effectiveness of the Spatial StimelMD (SSMD) device for upper-limb neuromotor rehabilitation in adults with impairment following stroke or traumatic brain injury (TBI).
Israel - Not yet recruitingNCT07159360
Safety, Usability, and Effectiveness of a Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders.
Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk.
Mexico, Spain - RecruitingNCT04047992
Seated Balance Using the Indego™
Exoskeleton-assisted walking (EAW) provides a new mobility option and appears to have potential therapeutic benefits for persons with SCI. However, present day technology is not sufficient to replace the wheelchair.
1 US site · New York - RecruitingNCT07222033
Self-balancing Personal Exoskeleton for SCI (WINY)
This study aims to demonstrate the safety and effectiveness of the personal exoskeleton in individuals with spinal cord injury (SCI).
1 US site · New York - RecruitingNCT06871254
Spinal Cord Injury Neurorecovery Collaboration
SCINC is an adaptive design Master protocol that seeks to determine if there is "sufficient promise" of beneficial effect of treatment combinations to enhance motor recovery in pre-specified strata of people with a spinal cord injury.
Australia - RecruitingNCT00178724
Spinal Cord Injury Registry - North American Clinical Trials Network
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI).
14 US sites · Florida, Kentucky, Louisiana, Maryland… - Not yet recruitingNCT07412808
Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study
Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI).
Italy - RecruitingNCT07153536
Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis
This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke.
1 US site · Pennsylvania - RecruitingNCT07222046
Spinal Neurorehabilitation for Veterans With SCI
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence.
1 US site · California - Not yet recruitingNCT07375745
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation.
Canada - RecruitingNCT06643312
TPAD for Recovery of Standing After Severe SCI
The purpose of this study is to investigate how standing and sitting balance control is altered after spinal cord injury (SCI) and how a new type of robotic assistive device may be used to improve muscle function. This device is called the Tethered Pelvic Assist Device, or TPAD.
1 US site · New Jersey - RecruitingNCT07022808
Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury
To achieve our specific aims and hypotheses we will conduct a parallel group mixed methods randomized control trial comparing participation in the TEEMS program with exercise via asynchronous video library equivalent (control).
1 US site · Pennsylvania - Not yet recruitingNCT06905470
The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation
The goal of this clinical trial is to assess the effects of eccentric arm-crank (KREHA) training compared to standard clinical routine strength (STAN) training in individuals undergoing primary spinal cord injury (SCI) rehabilitation.
Switzerland - Not yet recruitingNCT06726135
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated outcomes within a cohort of Major Trauma patients between 2015 and 2018…
- Not yet recruitingNCT04910204
Time-effect of FEST+TST in the Upper-extremity Rehabilitation of Individuals with Traumatic SCI
The purpose of this study is to investigate whether the timing of delivery of functional electrical stimulation therapy in combination with task-specific training (FEST+TST) following spinal cord injury (SCI) influences functional and neurological recovery.
Canada - RecruitingNCT07636135
Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy
The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical spine surgery.
Canada - Not yet recruitingNCT06802640
Transcutaneous Spinal Cord Electrical Stimulation Combined With Kunming Locomotor Training for the Treatment of Spinal Cord Injury
Spinal cord injury (SCI) is a common and severe traumatic central nervous system injury in clinical practice. Currently, the treatment of SCI remains a worldwide challenge.International studies have confirmed that TSCS is an effective non-invasive technique to activate the body's movement-related…
- Not yet recruitingNCT07445685
Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.
The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury. It will also learn about the safety of transcutaneous spinal cord stimulation when combined with assisted cycling training.
Spain - RecruitingNCT06313515
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities.
1 US site · Washington - Enrolling by invitationNCT06886386
TsDCS and Physical Therapy After Incomplete Spinal Cord Injury
The aim of this study is to evaluate the effects of tsDCS combined with physical therapy on the recovery of motor function in adult patients with chronic incomplete spinal cord injury.
Brazil - RecruitingNCT06808035
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination with transcutaneous spinal cord stimulation (scTS).
1 US site · Kentucky - RecruitingNCT04921592
Upper Extremity Training for Chronic Cervical Spinal Cord Injury
This study is to understand how the combination of activity-based recovery training and targeted spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hand, arms, and core.
1 US site · New Jersey - RecruitingNCT06782464
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add value in dealing with shoulder pain and functional problems caused by…
Luxembourg - Not yet recruitingNCT07361627
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury (SCI).
Canada - Not yet recruitingNCT07073313
Using Muscle Functional MRI to Study Spatial Muscle Activation Patterns in People With SCI
Several types of treatment and therapy have been shown to promote improvements in movement and other health gains in people with spinal cord injury (SCI).
- RecruitingNCT05317832
Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury
The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities.
1 US site · Pennsylvania - Not yet recruitingNCT07745686
VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury
The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce reliance on laboratory-based equipment during rehabilitation in…
Switzerland - RecruitingNCT07448883
Validity of the Turkish Translation of the Modified JOA
Degenerative cervical myelopathy (DCM) is the most common cause of non-traumatic spinal cord dysfunction in adults and may lead to progressive motor, sensory, and autonomic impairment.
Turkey (Türkiye) - Not yet recruitingNCT07019207
Virtual Reality Dual Task Training in SCI: Effects on Cognition and Cortical Activation
Spinal cord injury (SCI) is a severe neurological condition characterized by the loss of motor and sensory functions due to damage in the spinal cord or the nerves branching from it.
Turkey (Türkiye) - RecruitingNCT05005026
Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.
3 US sites · Alabama, Texas - Not yet recruitingNCT07380516
Xo-Motion R Exoskeleton in SCI-Adoption Study
After spinal cord injury (SCI), many people lose their ability to walk and do not have access to equipment and assistance that could help them regain functional abilities.
Canada - RecruitingNCT07750808
ZEPU AI9 Exoskeleton Rehabilitation Robot
The goal of this clinical trial is to learn whether the ZEPU AI9 lower limb exoskeleton robot is feasible, safe, and effective for people with walking difficulty caused by stroke, incomplete spinal cord injury, or orthopedic surgery.
Bangladesh - RecruitingNCT07749612
ZEPU-2000 Limb Rehabilitation Trainer Study (ZEPU2000RCT)
The goal of this clinical trial is to learn whether the ZEPU-2000A, ZEPU-2000D and ZEPU-2000E robotic rehabilitation trainers help people with weakness or movement problems in their arms and legs. These devices are used to guide repeated arm and leg movements as part of rehabilitation therapy.
Bangladesh - RecruitingNCT07749625
ZEPU-AI Series Limb Feedback Robot Training Study (ZEPUAISRCT)
The goal of this clinical trial is to learn whether robotic rehabilitation devices (ZEPU-AI2, AI4, AI6 Plus, and AI7A) are feasible, safe, and effective for adults with upper or lower limb motor problems.
Bangladesh - RecruitingNCT07735676
ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)
Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence.
Bangladesh - RecruitingNCT07705906
ZEPU-AI3 Lower Limb Feedback Robot Training Study
Lower limb motor dysfunction resulting from stroke, spinal cord injury, or other neurological disorders substantially limits mobility, independence, and quality of life. Robotic rehabilitation has emerged as a promising approach to provide intensive, repetitive, task-oriented training.
Bangladesh - RecruitingNCT07735702
ZEPU-AI5 Strength Training Study (ZEPUAI5RCT)
The goal of this clinical trial is to learn if robot-assisted lower-limb strength and gait training can improve safety, feasibility, and functional recovery in adults aged 18-60 years with lower-limb motor dysfunction due to stroke, incomplete spinal cord injury, or persistent gait impairment…
Bangladesh - RecruitingNCT07739264
ZEPU-SGI1PLUS Hand Training Study (ZEPUSGI1RCT)
The goal of this pilot randomized controlled trial is to learn whether the ZEPU-SG1PLUS Hand Functional Comprehensive Training System - a robotic device used alongside standard rehabilitation - is safe, feasible, and helpful for people with upper limb (arm/hand) motor problems caused by stroke,…
Bangladesh - RecruitingNCT07269977
mSCI: Mobile Health App for Veterans With SCI and Caregivers
Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation.
1 US site · Pennsylvania
Running, but closed to new participants (22)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT02274116
Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury
The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time.
1 US site · Massachusetts - Active, not recruitingNCT05619146
Arm and Leg Cycling for Accelerated Recovery From SCI
The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in individuals with an incomplete spinal cord injury.
1 US site · Illinois - Active, not recruitingNCT07768930
BCI-Guided Tibialis Anterior FES for Gait Training in Spinal Cord Injury
This study aims to investigate the effectiveness of Brain-Computer Interface (BCI)-guided Functional Electrical Stimulation (FES) in improving muscle activation and gait kinematics in individuals with Spinal Cord Injury (SCI).
Brazil - Active, not recruitingNCT03930056
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs. traditional care knee-ankle-foot-orthosis (KAFO) models following discharge from inpatient rehabilitation.
1 US site · Illinois - Active, not recruitingNCT02089880
Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis
The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic disease or trauma, as compared to the stance control orthosis.
1 US site · Illinois - Active, not recruitingNCT05351333
Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.
1 US site · Massachusetts - Active, not recruitingNCT04457206
Effectiveness of the Collaborative Community Clinic for Persons With Spinal Cord Injury and Disease
The investigator is evaluating data stored on the Collaborative Community Clinic data repository (IRB #201811032). Researchers seek to evaluate the effectiveness of the Collaborative Community Clinic (CCC), an occupational therapy student experiential learning clinic for uninsured or under-insured…
1 US site · Missouri - Active, not recruitingNCT07621900
Effects of Lokomat Training on Dynamic Postural Stability in Incomplete Spinal Cord Injury
The study aims to evaluate the effects of robotic-assisted gait training (Lokomat) on dynamic postural stability in patients with incomplete spinal cord injury (SCI).
Italy - Active, not recruitingNCT07669181
Examination of the Role of Human Exoskeletons in Rehabilitation
Background and Rationale: Traumatic spinal cord injury (SCI) affects approximately 12,400 individuals annually in the USA, predominantly impacting healthy young adults aged 20-40 years. Complete SCI above the lumbar region results in paraplegia or tetraplegia, severely compromising quality of life.
Hungary - Active, not recruitingNCT06524453
Exercise Program for Individuals With SCI in Community
Patients with spinal cord injury (SCI) who have reduced mobility have difficulty exercising on their own without proper guidance in the community. Community-based exercise programs are effective in removing various barriers such as lack of exercise programs, lack of experts, and lack of facilities.
South Korea - Active, not recruitingNCT06971510
Exoskeleton Training on Balance Control and Turning in Ambulation in Individuals With Incomplete Spinal Cord Injury
This study investigates the impact of exoskeleton training on individuals with incomplete spinal cord injury (iSCI). Investigators focus on assessing how the use of the exoskeleton influences balance control and turning during ambulation and quality of life in this population.
China - Active, not recruitingNCT04564495
Home Based Tele-exercise for People With Chronic Neurological Impairments
To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).
1 US site · New York - Active, not recruitingNCT03744286
Investigation Into an Innovative, Clinical Slip Inducing Device in the Chronic Incomplete Spinal Cord Population
The objective of this project is to fully test a newly developed affordable cost variable slip inducer in the ambulatory, incomplete spinal cord population.
1 US site · Illinois - Active, not recruitingNCT06872931
Investigation of the Effects of C-Mill (Hocoma AG, Switzerland) Treadmill Training on Trunk Balance in Patients with Spinal Cord Injury
This study examines how C-Mill treadmill training affects balance and stability in people with spinal cord injury (SCI). Many individuals with SCI experience difficulty with sitting and walking balance, which affects their daily activities and independence.
Turkey (Türkiye) - Active, not recruitingNCT06227000
Living Longer and Stronger With Spinal Cord Injury (SCI)
The purpose of this study is to develop a health promotion group intervention to meet the unique health promotion needs of people aging with SCI, to test the efficacy of the adapted intervention program, Living Longer and Stronger with SCI, in a randomized controlled trial and to assess the…
1 US site · Texas - Active, not recruitingNCT07739134
Multimodal Tracking of Therapy Activity and Effort During Rehabilitation
This study looks at whether everyday rehabilitation therapy sessions can be recorded and measured in a more complete, objective way. Today, therapists usually document sessions by hand, and the notes can vary a lot from one therapist to another.
Switzerland - Active, not recruitingNCT04798378
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one arm sufficient to perform daily activities.
2 US sites · Delaware, Pennsylvania - Active, not recruitingNCT06957483
Pilot Study of a Sedentary Behaviour Intervention for Individuals With a Spinal Cord Injury
Individuals with spinal cord injury have a greater risk of heart disease and stroke than non-disabled individuals. This might be partly because wheelchair users engage in high amounts of sedentary behaviour.
United Kingdom - Active, not recruitingNCT04041063
Rehabilitation and Cortical Remodeling After Surgical Intervention for Spinal Cord Injury
The aim of this study is to determine the effects of rehabilitation on dexterous hand movements and cortical motor map changes in tetraplegic patients following nerve transfer surgery.
1 US site · New York - Active, not recruitingNCT06069999
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
5 US sites · California, Florida, Pennsylvania, Utah - Active, not recruitingNCT06838975
Virtual Reality Rehabilitation for Cognitive, Emotional, and Motor Recovery in Neurological Disorders
This randomized controlled trial (RCT) evaluates the effectiveness of virtual reality (VR) rehabilitation in improving cognitive, emotional, social, and motor functions in patients with neurological disorders (ABI, SCI, MS, PD).
Italy - Active, not recruitingNCT05669508
Wearable Electrical Stimulation on the Back to Modulate Spinal Cord Activity
The goal of this study is to evaluate if non-invasive electrical spinal stimulation can help people with paralysis caused by SCI improve strength and function of their arms, legs, hands or feet.
1 US site · Pennsylvania
Completed and closed (425)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Completed NCT05167032 A Clinical Trial of Cognitive Multisensory Rehabilitation for Sensory and Motor Recovery in Adults With Spinal Cord Injury
- Completed NCT07170969 A Feasibility Trial of an Enhanced Coping-oriented Supportive Programme for Community-dwelling People With Spinal Cord Injury
- Completed NCT05940636 A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
- Unknown NCT05243576 A Novel System for Quasi Real-Time Tracking of Neuromuscular Responses During NMES
- Unknown NCT02746978 A Patient-centered Approach to Successful Community Transition After Catastrophic Injury
- Completed NCT06087445 A User-friendly, Non-invasive Neuro-orthosis That Restores Volitionally Controlled Grasp Functions for SCI Survivors With Tetraplegia
- Completed NCT02803255 AAN Robotic Therapy in SCI
- Terminated NCT03780829 AIH for Spinal Cord Repair
- Terminated NCT05390853 Active tDCS Versus Sham tDCS for Upper Limb Recovery in Incomplete Tetraplegic Patients
- Terminated NCT03261388 Activity Based Locomotor Exercise PrOgram-Wait-list controllEd Research
- Terminated NCT03669302 Activity-Dependent Transspinal Stimulation in SCI
- Completed NCT00523016 Acupuncture Treatment to Reduce Burning Pain in Spinal Cord Injury
- Completed NCT03267212 Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
- Completed NCT05061160 Acute Effects of Continuous Verses Interval Aerobic Training in Spinal Cord Injury Patient
- Completed NCT02441179 Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients
- Completed NCT02850133 Aerobic Exercise and Blood Biochemical Factors in Spinal Cord Injury
- Completed NCT04340063 Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
- Terminated NCT04137159 An Exercise Intervention to Reduce Neuropathic Pain and Brain Inflammation After Spinal Cord Injury
- Unknown NCT03150017 An Internet-Delivered Pain Management Programme for Spinal Cord Injury Pain
- Completed NCT06583538 An Online Rehabilitation Programme for People with SCI
- Completed NCT04474171 An Online Self-management Program for Spinal Cord Injury: Feasibility Study of SCI&U
- Completed NCT03962218 Aquatic Specific Physiotherapy on Incomplete Spinal Cord Injuries
- Terminated NCT02774603 Aquatic vs. Land Locomotor Training Overground Locomotor Training in Improving Ambulatory Function and Health-Related Quality of Life
- Completed NCT02098135 ArmeoSenso - Home Therapy and Assessment for Patients With Arm Impairments Based on Wearable Movement Sensors
- Completed NCT03914456 Assessment of Neurorehabilitation in Spinal Cord Injury Using Neuroimage Tools.
- Completed NCT02562001 Association Between tDCS and Lokomat Training in Patients With Incomplete Spinal Cord Injury
- Unknown NCT04211636 Autoimmunity And Immune Deficiency After Spinal Cord Injury: Association With Rehabilitation Outcomes
- Completed NCT02482194 Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study
- Completed NCT00221117 Benefits of Applying Neuroprosthesis to Improve Grasping and Reaching in Spinal Cord Injury Patients
- Completed NCT02731027 Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury
- Completed NCT04889092 Blood Flow Restriction Exercise for Those With SCI
- Completed NCT05425238 Blood Flow Restriction Resistance Exercise in Lower Cervical Spinal Cord Injury Patients
- Unknown NCT04641793 BoMI for Muscle Control
- Completed NCT02703883 Body Weight Support in Spinal Cord Injury
- Completed NCT03534518 Body Weight Supported Training Study
- Completed NCT02031835 Body Weight Supported Treadmill Training as Physical Therapy Treatment to Spinal Cord Injury Patients
- Completed NCT03307954 Bone Mineral Density Ekso Therapy Study
- Unknown NCT06161168 Bootle Blast: Understanding the Family Experience
- Completed NCT06813287 Brain Monitoring, tDCS and Robotic Training in SCI
- Completed NCT02443558 Brainwave Control of a Wearable Robotic Arm for Rehabilitation and Neurophysiological Study in Cervical Spine Injury
- Completed NCT03554733 Bridge Reinvention
- Completed NCT00013325 Cardiac Disease and the Electrocardiogram in SCI Patients
- Unknown NCT06027502 Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept
- Terminated NCT06259227 Cardiorespiratory Fitness Training in Patients With Incomplete Spinal Cord Injury
- Completed NCT01718977 Cardiovascular Health/Outcomes: Improvements Created by Exercise and Education in SCI (CHOICES)
- Terminated NCT03815721 Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity
- Completed NCT00816803 Cell Transplant in Spinal Cord Injury Patients
- Unknown NCT04263272 Circuit Training Program for Persons With Spinal Cord Injury
- Completed NCT04876794 Clinical Investigation on Safety, Feasibility and Usability of the ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
- Completed NCT05590065 Clinical Investigation on the Impact on Safety, Feasibility and Usability of the Design Changes Performed on ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
- Completed NCT02341950 Clinical Trial of a Serious Game for Individuals With SCI/D
- Unknown NCT05883917 Clinical Utility of Robot-Assisted Gait Training in Patients With Spinal Cord Injury Caused by Electrical Burns: A Case Report
- Unknown NCT00861393 Cognitive Behavioural Therapy (CBT) For Improving Emotional Well Being in Spinal Cord Injuries (SCI)
- Completed NCT04566809 Cognitive Rehabilitation and FES for Hand Functionality in Persons With Cervical Spinal Cord Injury
- Completed NCT04577573 Cognitive-based Prosthetics to Improve Grasp and Reaching After SCI
- Completed NCT01621113 Combination Therapy With Dalfampridine and Locomotor Training for Chronic, Motor Incomplete Spinal Cord Injury
- Completed NCT02554058 Combined Tactile and Proprioception Training After Spinal Cord Injury
- Terminated NCT06101199 Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
- Completed NCT02862080 Combining tsDCS and Exoskeleton Gait Training on Spinal Excitability in SCI
- Withdrawn NCT06169657 Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
- Completed NCT01407354 Comparison of Lokomat and Aquatic Exercise for Individuals With Chronic Incomplete Spinal Cord Injury
- Completed NCT05118971 Comparison of Muscle Activity in Exercise Bike and Elliptical Trainer in Individuals With Spinal Cord Injury
- Completed NCT01095380 Comparison of Post-pinal Cord Injury (SCI) Locomotor Training Techniques
- Completed NCT02161913 Comparison of Two Psycho-educational Family Group Interventions for Persons With SCI and Their Caregivers
- Completed NCT06912217 Comparison of the Effects of Robotic Rehabilitation, Functional Electrical Stimulation and Occupational Therapy on Upper Extremity and Hand Functions in Tetraplegic Patients With Spinal Cord Injury
- Completed NCT05071885 Computer Game-based Exercise Program Targeting Manual Dexterity for People With Spinal Cord Injury or Stroke.
- Terminated NCT03833518 Cortical Biomarkers of Hand Function and Recovery After Injury
- Completed NCT04592679 Cost-Effectiveness Analysis of a Rehabilitation Protocol With FES Cycling in Persons With Complete SCI
- Completed NCT02099357 Creatine or Vitamin D Supplementation in Persons With Spinal Cord Injury Undergoing Resistance Training
- Completed NCT04832802 Customized Employment for Veterans With Spinal Cord Injury
- Completed NCT02336321 Daily-life Brain Control Of A Hand Exoskeleton After Cervical Spinal Cord Injury
- Completed NCT04292717 Deficit-specific Training in Spinal Disorders
- Completed NCT06578780 Design and Delivery Preferences for Exercise Intervention in People With Spinal Cord Injury
- Unknown NCT04465825 Developing Strategies to Optimize the Exercise Response After Tetraplegia.
- Completed NCT01885962 Development and Feasibility of an Internet Intervention for Adults With Spinal Cord Injury to Prevent Pressure Ulcers
- Completed NCT02560506 Development of Low Cost Devices to Increase Access to Treadmill Training
- Completed NCT03137394 Development of a Model of Shoulder Pain Following Spinal Cord Injury
- Completed NCT05491837 Device-induced Intermittent Hypoxia in Persons With Incomplete Spinal Cord Injury
- Completed NCT01385384 Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries
- Unknown NCT01393977 Difference Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With Spinal Cord Injury in China
- Completed NCT01873547 Different Efficacy Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With SCI in China
- Completed NCT07467850 Dual Stimulation for Spinal Cord Injury
- Unknown NCT02917590 Dual-task Obstacle Crossing Training in Ambulatory Subjects With Spinal Cord Injury
- Completed NCT03611803 EFFECTS OF ROBOTIC TRAINING ON VASCULAR HEALTH OF INDIVIDUALS WITH SCI
- Terminated NCT03806023 EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals
- Completed NCT05255679 Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery
- Completed NCT01086930 Early Intensive Hand Rehabilitation After Spinal Cord Injury
- Unknown NCT02334410 Early Intervention to Reduce Bone Loss After Spinal Cord Injury
- Completed NCT02821845 Eccentric Motor Control After SCI
- Completed NCT06169969 Effect Of Magnetic Therapy In Bladder Dysfunction And Quality Of Life In Paraplegic Patients
- Completed NCT05558657 Effect of Acupressure on Constipation in Community-dwelling Spinal Cord Injury Patients: a Randomized Controlled Trial
- Completed NCT04625309 Effect of Adaptive Sports After Acquired Physical Disability
- Completed NCT07633249 Effect of Core Stability Training on Trunk Control and Sitting Balance in Patients With Paraplegia
- Terminated NCT01079169 Effect of Cranberry Capsules on Urinary Infection Rates in Spinal Cord Injured Patients During Post Acute Rehabilitation
- Completed NCT06214546 Effect of Different Support Systems on Gait
- Completed NCT01831414 Effect of Immersion Level on Respiratory Function of Spinal Cord Injury Patients During Balneotherapy
- Unknown NCT01386762 Effect of Intense Multi-modal Training on Bone Health and Quality of Life in Persons With Spinal Cord Injury
- Completed NCT00387673 Effect of Prolonged Electrical Stimulation on Neural Plasticity in Spinal Cord Injury
- Unknown NCT06547606 Effect of Resistive Inspiratory Muscle Training Optimizing Lung Function in Spinal Cord Injury
- Unknown NCT06627881 Effect of Three Training Programs on the Cardiovascular Condition of Individuals with Spinal Cord Injury
- Completed NCT04390087 Effect of Upper-body Rowing on Cardiometabolic Risk in Spinal Cord Injured Wheelchair Users
- Completed NCT02998021 Effect of Vibration Exercise on Upper Limb Strength, Function, and Pain
- Completed NCT03643770 Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
- Completed NCT04383873 Effectiveness Analysis of Armeo Spring Device as a Rehabilitation Treatment in Spinal Cord Injured Patients
- Completed NCT01147185 Effectiveness of Automated Locomotor Training in Patients With Acute Incomplete Spinal Cord Injury: A Multicenter Trial
- Completed NCT04790149 Effectiveness of NEUROM and tDCS for Motor Recovery in Chronic Paraplegia
- Completed NCT01889940 Effectiveness of Psycho-emotional Support in Acute Spinal Cord Injury. ESPELMA Project
- Completed NCT04809987 Effectiveness of Virtual Gait System Intervention in Motor Function in People With Incomplete Spinal Cord Injury.
- Completed NCT05447676 Effects of 4-AP on Functional SCI Recovery
- Completed NCT01272011 Effects of Breathing and Walking Treatments on Recovery Post-Spinal Cord Injury
- Completed NCT05008484 Effects of Electrical Stimulation and Vitamin D Supplementation on Bone Health Following Spinal Cord Injury.
- Completed NCT01202019 Effects of Exercise in People With Tetraplegia
- Withdrawn NCT04821635 Effects of FES-Rowing in Neurological Disorders (FES-ROW)
- Unknown NCT04164810 Effects of Hydrotherapy on Neuropathic Pain and Pain Catastrophization in Spinal Cord Injury
- Completed NCT05315115 Effects of Intensive Chiropractic Care to Usual Care for Adults With Spinal Cord Injuries.
- Completed NCT03851302 Effects of Remote Ischemic Conditioning on Hand Use in Individuals With SCI and ALS
- Completed NCT00127439 Effects of Robotic Versus Manually-Assisted Locomotor Training for Individuals With Incomplete Spinal Cord Injury
- Unknown NCT04160858 Effects of Spinal Cord Injury Exercise Guidelines
- Completed NCT03622710 Effects of Walking Training on Different Surfaces on Walking Ability in Ambulatory Patients With Spinal Cord Injury
- Completed NCT06444672 Effects of a Home-Based Rehabilitation on Anthropometric Measures, Sensory-Motor Functions and Independence After Spinal Cord Injury
- Terminated NCT01105260 Effects of an Early Wheelchair Reconditionong Program on Functional Independence in Spinal Cord-inured Individuals
- Completed NCT04910412 Effects of tDCS With Gait Training on Leg Performance in Incomplete Spinal Cord Injury
- Completed NCT01329757 Efficacy and Safety of Growth Hormone Treatment in Spinal Cord Injury
- Terminated NCT03513783 Elbow Extension Restoration Surgery in People With Tetraplegia: Evolution of the Muscular Co-activations of the Upper Limb During the Post-operative Rehabilitation
- Completed NCT03545867 Energetic Response to Feeding and Exercise in SCI
- Completed NCT03952416 Enhanced Medical Rehabilitation for Spinal Cord Injury
- Completed NCT03237234 Enhancing Corticospinal Activation for Improved Walking Function
- Completed NCT02833935 Enhancing Quality of Life Through Exercise: A Tele-Rehabilitation Approach
- Unknown NCT03320759 Enhancing Recovery in Non-Traumatic Spinal Cord Injury
- Completed NCT00610974 Enhancing Walking in People With Incomplete Spinal Cord Injury: a Pilot Study
- Completed NCT02339233 Epi Stim to Facilitate Standing and Stepping
- Completed NCT07717606 Epidural Stimulation and Rehabilitation for Spinal Cord Injury
- Completed NCT04736849 Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
- Completed NCT03385005 Evaluating Neuromuscular Stimulation for Restoring Hand Movements
- Completed NCT03477123 Evaluation of Robotic Exoskeletons Therapy for Gait Rehabilitation in Patients With Incomplete Spinal Cord Injury.
- Completed NCT04523636 Evaluation of Splinting in Tetraplegia
- Unknown NCT03171207 Evaluation of a Novel Gait Training Device to Support Body Weight
- Unknown NCT04316195 Evaluation of the Bulbocavernosus Reflex After Acute Spinal Cord Injury
- Completed NCT03452059 Evaluation of the Effectiveness and Safety of AI-Robotics
- Completed NCT01953666 Evaluation of the Efficiency of Word Prediction Software to Text Input Speed for Tetraplegia
- Unknown NCT00204126 Exercise Testing During Treadmill Gait in Incomplete Spinal Cord Injury
- Completed NCT03727893 Exercise Training and Manual Wheelchair Users With SCI
- Completed NCT04215081 ExoAtlet II For SCI Patients
- Completed NCT04221373 Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation
- Withdrawn NCT04532723 Exoskeleton-Assisted Walking ExoAtlet II
- Completed NCT07352085 Exoskeleton-assisted Neurorehabilitation
- Completed NCT04013997 Exoskeleton-assisted Walking in SCI Inpatient Rehabilitation
- Unknown NCT05267223 Experience of Rehabilitation Amongst Individuals With Paraplegia
- Completed NCT01652352 Experimental Evaluation of Wheelchair-Mounted Robotic Arms
- Completed NCT01238549 Extending Veteran Participation in the Validation of the SCI-QOL/CAT
- Completed NCT05432999 Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
- Completed NCT02008149 FES Rowing for Skeletal Health After SCI
- Completed NCT01208688 FES Therapy:Restoring Voluntary Grasping Function in Chronic SCI
- Completed NCT05908175 FES-assisted Gait Intervention in People with Spinal Cord Injury - Pilot Study
- Completed NCT03153033 Fatigue Induced by Overground Wheelchair Propulsion in Persons With a Spinal Cord Injury: Upper Limb Saving or Straining?
- Completed NCT03152110 Feasibility of HIIT in Spinal Cord Injury
- Completed NCT06230627 Feasibility of Home-Based Rehabilitation on Body Composition, Some Anthropometric Measures and Muscular Strength After Interruption 4-5 Years of Spinal Cord Injury: Serial Cases Study on ISIS War Survivors in Iraq
- Completed NCT03146728 Finding the Optimal Voluntary Exercise Parameters for Those Living With Quadriplegia
- Completed NCT04649814 Finnish Spinal Cord Injury Study (FinSCI)
- Completed NCT04307017 Fitness Training Using WBEMS Among Individuals With SCI
- Completed NCT04781621 Foundational Ingredients of Robotic Gait Training for People With Spinal Cord Injury During Inpatient Therapy
- Completed NCT03108950 From Clinic to Community: An Information and Communication Technology (ICT) Home-Based Exercise Training System for Translating Clinical Findings
- Terminated NCT03048331 Functional Electrical Stimulation (FES) and Reconstructive Tetraplegia Hand and Arm Surgery
- Unknown NCT04064385 Functional Electrical Stimulation Cycling in SCI
- Unknown NCT02602639 Functional Electrical Stimulation With Rowing as Exercise After Spinal Cord Injury
- Completed NCT05411692 Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury
- Completed NCT05221723 Functional Interval Training for People With Spinal Cord Injury and Their Care Partners
- Completed NCT00883142 Functional and Physiological Responses to Lokomat Therapy (Pilot Study)
- Completed NCT03343132 Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury
- Unknown NCT02808078 Gait Adaptation for Stroke Patients With Augmented Reality
- Terminated NCT03658798 Grasping Rehabilitation With Functional Electrical Stimulation Garment
- Completed NCT06892106 Gut Dysbiosis in Spinal Cord Injury Rehabilitation
- Completed NCT02201173 Health Outcomes After Locomotor Training in Spinal Cord Injury
- Completed NCT03743077 Health in Individuals With a Spinal Cord Injury: a Prospective Study
- Completed NCT06945835 High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction
- Completed NCT05951985 High Intensity Functional Training for Individuals With Neurologic Diagnoses and Their Care Partners
- Completed NCT04973852 High Intensity Training for Neurological Injury Using Overground Exoskeletons in Inpatient Rehabilitation
- Unknown NCT04397250 High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury
- Completed NCT05887752 Hunova® Randomized Controlled Trial for Trunk Control Improvement in Spinal Cord Injured Patients
- Terminated NCT03101982 Hyperbaric Oxygenation (HBO) in Traumatic Spinal Cord Injury. (EOS) - Pilot Study
- Completed NCT01739010 Hypothermia Following Acute Spinal Cord Injury
- Completed NCT02104622 Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation
- Completed NCT04706208 Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury
- Completed NCT04049994 Immunomodulation Therapy for Urinary Tract Infections
- Completed NCT03004144 Impact of Assistive Forces on Activities of Daily Living
- Completed NCT03567239 Impact of Custom Assistive and Adaptive Technology in Rehabilitation
- Completed NCT02748356 Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
- Completed NCT02748317 Impact of Probiotics on Urinary Symptoms in Spinal Cord Injury SCI and SB
- Unknown NCT04493606 Implementation of the ProACTIVE Toolkit in the Hospital and Community Setting
- Completed NCT04408287 Improving Activity Engagement Among Persons With SCI During COVID-19
- Completed NCT03011099 Improving Gait Performance in Individuals With Spinal Cord Injuries: an Intervention Using Robotic Exoskeletons
- Completed NCT00060983 Improving Gait in Patients With Spinal Cord Injuries
- Completed NCT01143597 Improving Hand and Arm Function After Spinal Cord Injury (SCI)
- Completed NCT05659121 Improving Mobility Via Robotic Exoskeletons in Local Rehabilitation Settings in Singapore
- Completed NCT03892746 Improving SCI Rehabilitation Interventions by Retraining the Brain
- Unknown NCT03140501 Improving Self-Management Skills Among People With Spinal Cord Injury
- Completed NCT01539109 Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain With Stimulation
- Completed NCT03244098 In-Home Adjustment of New Spinal Cord Injury Caregivers
- Completed NCT02793635 Indego Exoskeleton After SCI
- No longer available NCT04064957 Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury
Showing 200 of 425 closed studies. The rest are in the Trials Finder and on the state pages below.
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".