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Safety Clinical Trials for Spinal Cord Injury

SCI.help tracks 67 spinal cord injury clinical trials studying safety, and 12 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.

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This is research, not treatment. A clinical trial is a study. It may involve a placebo, carries unknown risks, and is not a substitute for proven care. Be wary of any "trial" that charges you to take part. Talk with your SCI doctor before enrolling, and read the full eligibility and risks on ClinicalTrials.gov. Not medical advice.

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Open and recruiting (12)

These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.

  • Not yet recruitingNCT07799532

    A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury

    The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291.

    DrugsSafetyBlood PressureHand MovementMotor FunctionQuality of LifeSpasticityTemperature Control
    18 US sites · Alabama, California, Colorado, Connecticut…
  • RecruitingNCT04936620

    Duroplasty for Injured Cervical Spinal Cord With Uncontrolled Swelling

    QUESTION. Does duroplasty improve outcome after spinal cord injury? WHAT DO WE STUDY? We will investigate whether performing a surgical procedure called duroplasty improves outcomes after spinal cord injury.

    Safety
    Austria, Belgium, China, Czechia…
  • Not yet recruitingNCT06974968

    Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial

    Purpose: This clinical trial is studying an investigational cell therapy called XS228-a lab-made stem cell product designed to help repair damaged nerves in the spinal cord.

    SafetyStem CellsBladder FunctionBowel FunctionMotor FunctionQuality of LifeSensory Function
    China
  • RecruitingNCT01571531

    European Multicentre Study of Human Spinal Cord Injury

    Today there is accumulating evidence from animal experiments that regeneration can be induced after a spinal cord injury (SCI). Consequently in the near future, new therapeutic approaches to induce some regeneration will be included in the treatment of patients with SCI.

    Safety
    Switzerland
  • RecruitingNCT05302999

    Feasibility of Early Gabapentin as an Intervention for Neurorecovery

    The objective of the proposed study is to conduct the first ever prospective, dose-exploration trial to test the feasibility of early administration of gabapentin as an intervention for neurorecovery.

    Safety
    1 US site · Ohio
  • RecruitingNCT04474106

    NEUROwave - Extracorporeal Shock Wave Therapy (ESWT) in Acute Traumatic Complete (AIS A) and Incomplete (AIS B-D) Cross-sectional Lesions on Motor and Sensory Function Within Six Months After Injury

    It has been hypothesized that there are two mechanisms of acute traumatic spinal cord injury (SCI): the primary mechanical damage and the secondary injury due to additional pathological processes initiated by the primary injury.

    Safety
    Austria
  • Not yet recruitingNCT07739043

    NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI

    The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume calculated using M = 0.167 mL/kg BW.

    DrugsSafetyStem Cells
    1 US site · Illinois
  • RecruitingNCT04054414

    PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury

    This was a prospective, multicentric, randomized, double blind, parallel, saline controlled Phase II clinical study to compare the safety and efficacy of PMZ-1620 (INN: Sovateltide) therapy along with standard supportive care in patients of acute spinal cord injury.

    Safety
    India
  • RecruitingNCT05426681

    Spinal Cord Injury Neuroprotection With Glyburide

    To assess the safety and efficacy of using oral Glyburide (Diabeta) as a neuroprotective agent in patients with acute cervical or thoracic traumatic spinal cord injury.

    Safety
    1 US site · Kentucky
  • RecruitingNCT02991690

    Systemic Hypothermia in Acute Cervical Spinal Cord Injury

    This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).

    Safety
    7 US sites · Arizona, Florida, Georgia, Indiana…
  • Enrolling by invitationNCT04565366

    Transforming Research and Clinical Knowledge in Spinal Cord Injury

    The overall goal of Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker characteristics of acute traumatic spinal cord injury (SCI).

    Safety
    5 US sites · California, Ohio, Utah, Washington
  • Not yet recruitingNCT07745686

    VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury

    The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce reliance on laboratory-based equipment during rehabilitation in…

    Brain Machine Interface (BMI)DevicesElectrical StimulationEpidural StimulationExoskeletonRehabilitationSafetyMotor FunctionWalking Function
    Switzerland

Running, but closed to new participants (1)

Active studies that are no longer enrolling. Useful for seeing where the field is heading.

  • Active, not recruitingNCT07295067

    Extracellular Vesicles for the Treatment of Syringomyelia

    This is a open-label, single-arm, dose escalation phase I clinical trial. The goal of this clinical trial is to evaluate the safety and preliminary efficacy of Intrathecal injection human umbilical cord-derived mesenchymal stromal cell-derived extracellular vesicle (hUC-MSC-sEV) in syringomyelia.

    DrugsSafetyStem CellsBreathing Function
    China

Completed and closed (54)

Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.

  • Completed NCT05308953 A Phase I Safety Study of NVG-291 in Healthy Adults
  • Completed NCT00500812 A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries
  • Completed NCT01748695 A Safety, Tolerability and Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury
  • Completed NCT00654082 A Study Evaluating the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction
  • Completed NCT00406016 Acute Safety, Tolerability, Feasibility and Pharmacokinetics of Intrath. Administered ATI355 in Patients With Acute SCI
  • Completed NCT02260713 Autologous Bone Marrow Cell Transplantation in Persons With Acute Spinal Cord Injury- An Indian Pilot Study.
  • Completed NCT01572376 Autologous Bone Marrow Stem Cells in Pressure Ulcer Treatment
  • Completed NCT02469675 Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
  • Unknown NCT03911492 Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
  • Completed NCT00135278 Cerebrospinal Fluid (CSF) Drainage and Cytokine Profiling in the Treatment of Acute Spinal Cord Injury (SCI)
  • Unknown NCT04758377 Characterizing Hemorrhage in Acute Spinal Cord Injury With MRI
  • Completed NCT05590065 Clinical Investigation on the Impact on Safety, Feasibility and Usability of the Design Changes Performed on ABLE Exoskeleton Device With Spinal Cord Injured Patients in a Hospital Setting
  • Unknown NCT03643419 Clinical Study of Treatment of Acute Spinal Cord Injury by Near Infrared Light Irradiation
  • Unknown NCT05693181 Cord Blood Cells in Patients With Acute SCI
  • Completed NCT02302157 Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
  • Completed NCT07467850 Dual Stimulation for Spinal Cord Injury
  • Completed NCT02268266 ERIGO® Life- Control of Cardiovascular Parameters Via Verticalization and Simultaneous Mobilization
  • Completed NCT05398913 Effects of Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury
  • Unknown NCT03103516 Epidural Decompression Surgery Within 24 Hours After Acute Spinal Cord Injury Improves Spinal Nerve Function
  • Completed NCT00654680 Evaluating the Efficacy and Safety of Vardenafil in Patients Erectile Dysfunction Solely Secondary to Spinal Cord Injury
  • Completed NCT03144830 Exoskeleton Use in Acute Rehab Post Spinal Cord Injury; a Safety and Feasibility Study
  • Withdrawn NCT04532723 Exoskeleton-Assisted Walking ExoAtlet II
  • Completed NCT04211311 Hybrid High-intensity Interval Training for Persons With Spinal Cord Injury. A Feasibility Study
  • Unknown NCT02721615 Injured Spinal Cord Pressure Evaluation
  • Unknown NCT04550117 Intraspinal Pressure Monitoring for Acute Traumatic Spinal Cord Injury: A Validation Study
  • Unknown NCT03521336 Intrathecal Transplantation of UC-MSC in Patients With Sub-Acute Spinal Cord Injury
  • Completed NCT03945110 Intravesical Glycosaminoglycan Instillation and Urinary Tract Infection in Acute Spinal Cord Injury
  • Unknown NCT05360524 Laminectomy Alone Versus Laminectomy and Fusion for Traumatic Cervical Spinal Cord Injury Without Instability
  • Completed NCT02600013 Locomotor Training With Exoskeleton EKSO-GT in Patients With Incomplete Motor Spinal Cord Injury in a Hospital Setting
  • Completed NCT00559494 Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury
  • Completed NCT05965700 NVG-291 in Spinal Cord Injury Subjects
  • Unknown NCT04811235 Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
  • Unknown NCT04475224 Phase 3 Study of KP-100IT in Subjects With Acute Spinal Cord Injury
  • Withdrawn NCT03105882 Pilot Study of the Neuro-Spinal Scaffold for the Treatment of AIS A Cervical Acute SCI
  • Unknown NCT05244408 SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation
  • Withdrawn NCT05041114 SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
  • Completed NCT02096913 Safety Study of Ibuprofen to Treat Acute Traumatic Spinal Cord Injury
  • Completed NCT01135108 Safety and Efficacy Study of KAI-1678 to Treat Pain in Subjects With Spinal Cord Injury
  • Completed NCT01186679 Safety and Efficacy of Autologous Bone Marrow Stem Cells in Treating Spinal Cord Injury
  • Completed NCT02417532 Safety and Feasibility Evaluation of Robot Assisted Physiotherapy Exercises With REX
  • Withdrawn NCT02237547 Safety and Feasibility Study of Cell Therapy in Treatment of Spinal Cord Injury
  • Completed NCT05601661 Safety and Feasibility of Paired Vagus Nerve Stimulation With Rehabilitation for Improving Upper Extremity Function in People With Cervical Spinal Cord Injury
  • Completed NCT01046786 Safety and Feasibility of Umbilical Cord Blood Cell Transplant Into Injured Spinal Cord
  • Completed NCT03168828 Safety and Tolerability of TAR-302-5018 in Subjects With Neurogenic Detrusor Overactivity Resulting From Spinal Cord Injury
  • Withdrawn NCT06347575 Safety and Tolerability of a Novel Implantable Neurostimulator for Ameliorate Erectile Function on Spinal Cord Injured Patients
  • Completed NCT06117020 Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals
  • Unknown NCT03935724 Stem Cells in Spinal Cord Injury
  • Unknown NCT03529708 Stereotactic Body Radiotherapy Boost After Palliative Radiotherapy for Spinal Cord Compression
  • Withdrawn NCT04196114 Study on Feasibility of Stimulation on the Lumbar Part of the Spinal Cord to Improve Mobility Recovery in Patients With Sub-acute Spinal Cord Injury
  • Completed NCT01484184 Study to Assess Safety, Tolerability and MTD of a Central Pattern Generator-activating Tritherapy (SPINALON) in Patients With Chronic Spinal Cord Injury
  • Completed NCT05524103 Study to Evaluate the Safety and Pharmacokinetics of ALMB-0166 in Patients With Acute Spinal Cord Injury
  • Unknown NCT04988425 TNFα Monoclonal Antibody for Acute Spinal Cord Injury
  • Unknown NCT02363361 Treatment of Cervical Spinal Cord Injury With Imatinib - a Safety and Feasibility Study
  • Completed NCT01642901 Zoledronic Acid in Acute Spinal Cord Injury

Where this list comes from

Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.

Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".