Transcutaneous Stimulation Clinical Trials for Spinal Cord Injury
SCI.help tracks 148 spinal cord injury clinical trials studying transcutaneous stimulation, and 75 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.
Open these in the Trials Finder → Add a target (walking, bladder, pain…), a state, or a status filter.
Other treatment categories
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
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Open and recruiting (75)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- RecruitingNCT06494059
A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients
The purpose of this research is to explore the effect of magnetic stimulation to activate the brain, electrical spinal cord stimulation to activate spinal cord, and electrical muscle stimulation used to activate upper limb (arms), lower limb (legs) and trunk (stomach) muscles in people with spinal…
1 US site · Florida - Not yet recruitingNCT07452133
AI-Powered Closed-Loop Multielectrode Transcutaneous Spinal Cord Stimulation: Real-Time Adjustments for Enhanced Motor Recovery in Spinal Cord Injury (AIM RECOVER)
Spinal cord injury (SCI) often results in persistent motor deficits that are inadequately addressed by conventional rehabilitation.
Singapore - RecruitingNCT06472986
Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)
The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.
Canada - RecruitingNCT07210411
Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury
The purpose of this research is to learn about how the participant's body is able to balance changes in blood pressure, and how spinal cord stimulation affects these changes as well as immune \& cardiovascular function in participants with spinal cord injury.
1 US site · Minnesota - Enrolling by invitationNCT06873776
Arm and Leg Cycling for Accelerated SCI Recovery
The purpose of this study is to examine interventions with paradigms involving upper and lower extremity cycling (A\&L cycling) with A\&L cycling with functional electrical stimulation (FES) (A\&L\_FES group), A\&L cycling with FES and transcutaneous Spinal Cord Stimulation (A\&L\_tSCS group), and…
1 US site · Illinois - RecruitingNCT06406855
Brain-Controlled Spinal Stimulation Walking Therapy After Incomplete Spinal Cord Injury (SCI)
The purpose of this research is to test the effectiveness of a new therapy, called Brain-Computer Interface (BCI)-Transcutaneous Spinal Cord Stimulation (TSCS), for improving walking in people with an incomplete spinal cord injury (SCI).
1 US site · Florida - Not yet recruitingNCT07659743
BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI)
The purpose of this study is to compare the effectiveness of innovative intervention of breathing controlled electrical stimulation (BreEStim) and sham BreEStim and Transcutaneous Electrical Nerve Stimulation (TENS) in management of neuropathic pain in patients after spinal cord injury (SCI).
1 US site · Texas - Not yet recruitingNCT06379711
Cardiopulmonary Changes Following Spinal Cord Stimulation in Individuals With Spinal Cord Injury
The aim of this study is to examine the mechanisms of transcutaneous spinal cord stimulation (tSCS) for improving cardiovascular and pulmonary function in individuals with chronic motor-complete spinal cord injury (SCI) by measuring vascular related endothelial biomarkers, plasma catecholamines,…
Canada - RecruitingNCT06841198
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect blood pressure.
1 US site · New Jersey - RecruitingNCT05267951
Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury
The purpose of this study is to assess the efficacy of non-invasive (transcutaneous) closed-loop electrical spinal cord stimulation for recovery of upper limb function (Aim 1) and spasticity (Aim 2) following spinal cord injury.
1 US site · Washington - RecruitingNCT05563103
Combination Therapy to Improve SCI Recovery.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.
2 US sites · Illinois, Massachusetts - Not yet recruitingNCT07595497
Combined TMS-tSCS for Lower Limb Rehabilitation in Chronic Incomplete SCI
he goal of this clinical trial is to learn if combined brain and spinal cord stimulation using TMS-tSCS can improve leg strength and walking recovery in adults with chronic incomplete spinal cord injury.
Singapore - Not yet recruitingNCT07586644
Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI
This clinical trial investigates whether combining cortical and spinal neuromodulation can improve upper limb motor recovery in adults with chronic incomplete cervical spinal cord injury (SCI).
Singapore - RecruitingNCT06773286
Combining Spinal Cord Transcutaneous Stimulation and Activity-based Training in Inpatient Rehabilitation to Facilitate Upper Limb Function of Individuals with Acute to Subacute Cervical Spinal Cord Injury
The purpose of this clinical trial is to understand the safety and practicality of using spinal cord transcutaneous (through the skin) stimulation in an inpatient setting as well as how the combination of activity-based training (ABT) and spinal cord transcutaneous stimulation (scTS) can improve…
1 US site · New Jersey - RecruitingNCT07289191
Development of a Novel Strategy to Analyze the Effect on Gait Using Transcutaneous Spinal Current Stimulation in Incomplete Spinal Cord Injured Patients
To determine whether the combination of non-invasive spinal cord stimulation together with gait rehabilitation reduces spasticity and facilitates recovery of lower limb motor strength and gait function in patients with incomplete SCI, as well as studying the underlying physiopathological changes…
Spain - RecruitingNCT06853015
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
1 US site · Illinois - RecruitingNCT06596174
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
Taiwan - RecruitingNCT06520020
Evaluating Safety and Feasibility of Transcutaneous Spinal Cord Stimulation Following Traumatic and Non-Traumatic Spinal Cord Injury: A Pilot Study
The study will be a non-randomized, non-blinded pilot study to analyze the safety and feasibility of a non-significant risk device, transcutaneous spinal cord stimulation. The aim is to include 30 total patients, 10 patients in each of 3 groups: 1.
1 US site · Kentucky - RecruitingNCT06104735
Finding the Best Combination of Brain and Spinal Cord Stimulation With Hand Training After Spinal Cord Injury
While physical exercise remains the foundation for any rehabilitation therapy, the team seeks to improve the benefits of exercise by combining it with the concept of "Fire Together, Wire Together" - when brain stimulation is synchronized with spinal cord stimulation, nerve circuits in the spinal…
1 US site · New York - RecruitingNCT06213012
Harnessing Neuroplasticity of Postural Sensorimotor Networks Using Non-Invasive Spinal Neuromodulation to Maximize Functional Recovery After Spinal Cord Injury
It has been demonstrated that the human lumbosacral spinal cord can be neuromodulated with epidural (ESS) and transcutaneous (TSS) spinal cord stimulation to enable recovery of standing and volitional control of the lower limbs after complete motor paralysis due to spinal cord injury (SCI).
1 US site · Texas - Not yet recruitingNCT07438353
Home-Based Digital Rehabilitation Program Optimized With Transcutaneous Spinal Cord Stimulation for Upper Limb Functional Enhancement in Tetraplegia (HOPE): A Safety, Efficacy, and Feasibility Study
Individuals with chronic cervical spinal cord injury (SCI) and tetraplegia commonly experience persistent impairment in upper limb function, leading to reduced independence and quality of life.
Singapore - Not yet recruitingNCT07674511
Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury
The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury. The main questions this study attempts to solve: 1.
1 US site · New Jersey - RecruitingNCT06214208
Influence of Spinal Stimulation Frequency on Spasticity, Motor Control, and Pain After Spinal Cord Injury
The goal of this study is to identify the effect of different types of noninvasive spinal stimulation on spasticity (involuntary muscle activity), muscle strength, and pain in people with spinal cord injury.
1 US site · Georgia - RecruitingNCT06521723
Low Oxygen Therapy to Enhance Walking Recovery After SCI.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.
2 US sites · Florida, Massachusetts - RecruitingNCT07204184
Multisite Transspinal Stimulation for Augmenting Recovery in Spinal Cord Injury
A well-established rehabilitation strategy for improvements of standing and walking ability in persons with spinal cord injury (SCI) is step training on a motorized treadmill with body weight support. A promising intervention is stimulation of the spinal cord through the skin (transspinal).
1 US site · New York - RecruitingNCT06272279
Neuromodulation With Spinal Stimulation Methods
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled. A variety of stimulation parameters and outcome measures will be assessed.
Canada - Enrolling by invitationNCT04077346
Neuromodulation of Spinal Locomotor Circuitry to Elicit Stepping After Pediatric Spinal Cord Injury
Spinal cord injury (SCI) results in damage to the descending neural pathways and leads to the immediate dysfunction of multiple physiological systems below the level of injury. Like adults, children with SCI suffer from neuromuscular paralysis which results in the inability to sit, stand, and walk.
1 US site · Kentucky - RecruitingNCT05756894
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in respiratory function and recovery using stimulation and respiratory exercise…
1 US site · Illinois - RecruitingNCT05183152
Non-invasive BCI-controlled Assistive Devices
Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…
1 US site · Texas - RecruitingNCT07504055
Non-invasive Spinal Cord Stimulation and Blood Pressure Regulation After Spinal Cord Injury
The goal of this clinical trial is to learn if non-invasive spinal cord stimulation intervention improves blood pressure regulation in individuals with chronic spinal cord injury.
2 US sites · Kentucky - RecruitingNCT05369520
Non-invasive Spinal Cord Stimulation for Recovery of Autonomic Function After Spinal Cord Injury
This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).
Canada - RecruitingNCT06587841
Noninvasive Spinal Cord Stimulation for Early SCI
The investigators are looking to determine the safety and efficacy of non-invasive transcutaneous spinal cord stimulation (TSCS) in promoting recovery of lower urinary tract (LUT), bowel, sexual, and cardiovascular function, as well as spasticity in individuals with subacute and chronic SCI (time…
Canada - Enrolling by invitationNCT06489106
Noninvasive Spinal Stimulation to Restore Hand Function in Children With Spinal Cord Injury
The main goal of this pilot study is to find the best ways to use transcutaneous spinal cord stimulation (scTS) to improve hand function in children with spinal cord injuries (SCI).
1 US site · Kentucky - Not yet recruitingNCT06698224
Paired Spinal Cord and Peripheral Nerve Stimulation to Recover Hand Function in SCI
Individuals who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles.
1 US site · New Jersey - Not yet recruitingNCT07562113
Pilot Testing of Vagus Nerve Stimulation for Early Spinal Cord Injury Recovery
This study looks at a treatment called transcutaneous auricular vagus nerve stimulation, or taVNS. taVNS uses a small device worn on the ear to gently stimulate a nerve. Researchers want to find out if this treatment is safe and well-tolerated for people who recently had a spinal cord injury (SCI).
1 US site · Alabama - RecruitingNCT07511244
SCS Therapy for Patients With Bladder and Bowel Dysfunction After SCI
This clinical trial aims to evaluate the safety and efficacy of spinal cord stimulation (SCS) in treating patients with urinary and bowel dysfunction after spinal cord injury (SCI).
China - RecruitingNCT06543277
Safety and Feasibility of Paired Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) With Upper Limb Rehabilitation in Incomplete Spinal Cord Injury
The purpose of this study is to evaluate the safety and feasibility of transcutaneous auricular Vagus Nerve Stimulation (taVNS) paired with upper-limb rehabilitation in adults with tetraplegia caused by cervical spinal cord injury.
2 US sites · Texas - RecruitingNCT06000592
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI).
1 US site · New York - RecruitingNCT07397559
Spatiotemporal tSCS in Spinal Cord Injury
Spinal cord injury leads to long-lasting impairment, and currently, there is no cure for paralysis. Although transcutaneous spinal cord stimulation has shown promising results in recovering lost movements, its poor selectivity in muscle recruitment compared to invasive approaches limits the type of…
1 US site · Missouri - RecruitingNCT05472584
Spinal Cord Stimulation and Training
This study will help the investigators better understand the changes in short-term excitability and long-term plasticity of corticospinal, reticulospinal and spinal neural circuits and how the changes impact the improvements of spinal cord stimulation (SCS) mediated motor function.
1 US site · Missouri - RecruitingNCT06540859
Spinal Cord Stimulation for Autonomic Recovery in Inpatient Rehabilitation After Acute SCI
This study is a randomized, single-blind, two-arm sham-controlled clinical trial to evaluate the safety and efficacy of transcutaneous spinal cord stimulation (tSCS) over the lower thoracic and upper lumbar spinal cord segments for cardiovascular function in adults (21-65 years old) with cervical…
1 US site · Washington - RecruitingNCT05157282
Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia
In support of the long-term goal of developing new strategies to increase limb function after SCI, the objectives of this proposal are to: 1) Examine the behavioral and physiological effects of TESS on upper-limb muscles after cervical SCI; and 2) Maximize the recovery of reaching and grasping…
2 US sites · Illinois - RecruitingNCT06019949
Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury
Respiratory complications are among the leading causes of death in patients with chronic spinal cord injury (SCI). Our previous work showed that pulmonary function can be improved by using our original respiratory training method.
1 US site · Kentucky - RecruitingNCT05731986
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
1 US site · New Jersey - Enrolling by invitationNCT07683780
Spinal Stimulation + FES-Assisted Cough Training in SCI
The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective intervention to improve cough strength and coordination in individuals with…
1 US site · Illinois - Not yet recruitingNCT07375745
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (\< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to rehabilitation and external stimulation.
Canada - RecruitingNCT06743607
Spinal Stimulation for Upper Extremity Recovery in the Home
The purpose of this research is to evaluate the safety, feasibility, and tolerability of non-invasive spinal stimulation used in the home and/or community in combination with a functional home exercise program for the upper extremities (arm/hand function) as well as their combined impacts on…
1 US site · Colorado - RecruitingNCT07334977
Synergistic Effect of Non-invasive Brain and Spinal Cord Stimulation
The goal of this clinical study is to investigate the potential synergy between non-invasive brain and spinal cord stimulation administered during a cognitive-motor task, in terms of their immediate effects on sensorimotor and cognitive functions after neurological injuries affecting the upper limb…
France - RecruitingNCT05305118
TSCS for Acute SCI
This project will focus on a novel approach to stabilizing blood pressure (BP) during inpatient rehabilitation after acute SCI. After SCI, people have unstable blood pressure, ranging from too low (orthostatic hypotension) to too high (autonomic dysreflexia).
1 US site · New York - Not yet recruitingNCT07785258
TTNS in SCI Patients With Neurogenic Detrusor Overactivity
This is a prospective, single-arm, pilot study to assess effectiveness and tolerability of transcutaneous tibial nerve stimulation (TTNS) in managing neurogenic detrusor overactivity in spinal cord injury patients.
Singapore - Not yet recruitingNCT07325149
The Effect of Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation on Bone Strength.
Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical complications that can devastate quality of life.
1 US site · New Jersey - RecruitingNCT05725499
The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
This project will investigate the effect of spinal cord transcutaneous stimulation on blood pressure in individuals with a chronic spinal cord injury who experience blood pressure instability, specifically, orthostatic hypotension (a drop in blood pressure when moving from lying flat on your back…
1 US site · New Jersey - RecruitingNCT07578532
The Effectiveness of Transcutaneous Sacral Neuromodulation Techniques-Magnetic Stimulation and Electrical Stimulation-on Detrusor Overactivity in Patients With Spinal Cord Injury
The goal of this prospective, randomized clinical trial is to compare the efficacy and safety of transcutaneous sacral magnetic stimulation versus sacral electrical stimulation for detrusor overactivity in 40 male and female patients aged 18-65 with suprasacral Spinal Cord Injury (SCI) whose DOA is…
Turkey (Türkiye) - RecruitingNCT07136688
Tibial Nerve Stimulation for Pediatric Spina Bifida Neurogenic Bladder
The purpose of this study is to determine the safety, feasibility, and compliance of a daily home transcutaneous tibial nerve stimulation (tTNS) protocol in children with chronic neurogenic bladder (NB) provided by self or caregiver for 4 weeks and to estimate the efficacy of tTNS
1 US site · Texas - Not yet recruitingNCT06802640
Transcutaneous Spinal Cord Electrical Stimulation Combined With Kunming Locomotor Training for the Treatment of Spinal Cord Injury
Spinal cord injury (SCI) is a common and severe traumatic central nervous system injury in clinical practice. Currently, the treatment of SCI remains a worldwide challenge.International studies have confirmed that TSCS is an effective non-invasive technique to activate the body's movement-related…
- Not yet recruitingNCT07445685
Transcutaneous Spinal Cord Stimulation (tSCS) During Assisted Cycling Training for Incomplete Spinal Cord Injury.
The goal of this clinical trial is to learn if transcutaneous spinal cord stimulation works to improve lower limb motor function in adults with incomplete spinal cord injury. It will also learn about the safety of transcutaneous spinal cord stimulation when combined with assisted cycling training.
Spain - RecruitingNCT06313515
Transcutaneous Spinal Cord Stimulation Combined With Arm Bike for Cardiovascular Recovery in SCI
Spinal cord injury (SCI) can make it hard for the body to self-regulate some of its automatic functions like blood pressure, breathing, and heart rate. This can also make it hard for those living with SCI to exercise or complete their usual daily activities.
1 US site · Washington - RecruitingNCT06838637
Transcutaneous Spinal Cord Stimulation Home Study
The goal of this pilot clinical trial is to examine the safety and feasibility of SCONE as home based therapy for orthostatic hypotension and bowel dysfunction in individuals with spinal cord injury or multiple system atrophy.
Canada - RecruitingNCT05921175
Transcutaneous Spinal Cord Stimulation With Robotic Gait Training in Chronic SCI
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment robotic gait training (RGT) to improve functional mobility in participants with chronic spinal cord injuries.
Singapore - Not yet recruitingNCT06801431
Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury
The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic spinal cord injury admitted to inpatient rehabilitation.
- RecruitingNCT06596369
Transcutaneous Spinal Cord Stimulation for Upper Extremity Function
Transcutaneous electrical stimulation (tcES) of the spinal cord has shown great promise in restoring upper extremity function after spinal cord injury (SCI).
Canada - RecruitingNCT06242873
Transcutaneous Spinal Cord Stimulation in Children With Incomplete Spinal Cord Injury
Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups. Both groups will receive eight-weeks of individualized gait training.
1 US site · Maryland - RecruitingNCT07692191
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
Canada - Enrolling by invitationNCT04032990
Transcutaneous Spinal Stimulation: Safety and Feasibility for Upper Limb Function in Children With Spinal Cord Injury
Children who suffer a spinal cord injury in the neck region have difficulty using their hands due to paralysis and/or weakness of their arms and hand muscles.
1 US site · Kentucky - RecruitingNCT03965299
Transcutaneous Tibial Nerve Stimulation in Acute Spinal Cord Injury
Most patients with spinal cord injury (SCI) develop neurogenic lower urinary tract dysfunction (NLUTD), one of the most devastating sequelae of SCI which ultimately can lead to renal failure. We urgently need an intervention that prevents NLUTD before irreversible damage occurs.
Switzerland - RecruitingNCT05423600
Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia
The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities greater than BES+sham TS in persons with chronic, incomplete…
3 US sites · Virginia - Enrolling by invitationNCT05122325
Treatment for Sexual Dysfunction in Women with Spinal Cord Injury
Women with spinal cord injury frequently experience sexual dysfunction such as disturbances during arousal and an increased time to orgasm. However, little evidence has been found on its therapeutic approach and low adherence.
Spain - Enrolling by invitationNCT06886386
TsDCS and Physical Therapy After Incomplete Spinal Cord Injury
The aim of this study is to evaluate the effects of tsDCS combined with physical therapy on the recovery of motor function in adult patients with chronic incomplete spinal cord injury.
Brazil - RecruitingNCT06808035
Understanding Perinatal Spinal Cord Injury
The purpose of this study is to deepen our understanding of children who have a cervical spinal cord injury obtained in utero or at birth and examine the effects of tailored activity-based recovery training (ABRT) in combination with transcutaneous spinal cord stimulation (scTS).
1 US site · Kentucky - RecruitingNCT04921592
Upper Extremity Training for Chronic Cervical Spinal Cord Injury
This study is to understand how the combination of activity-based recovery training and targeted spinal cord transcutaneous stimulation (scTS) can improve participants' ability to use their hand, arms, and core.
1 US site · New Jersey - Not yet recruitingNCT07361627
Upper Limb Rehabilitation Using Non-invasive Spinal Cord Stimulation
The goal of this RCT study is to evaluate if combining activity-based therapy (ABT) with transcutaneous spinal cord stimulation (tSCS) can improve recovery of arm and hand movement in people with cervical spinal cord injury (SCI).
Canada - RecruitingNCT05991804
Upper Limb Spinal Cord Stimulation for Rehabilitation Enhancement
In the United Kingdom, there are more than 1000 new cases of spinal cord injury (SCI) each year, with around half of these injuries affecting the cervical spine.
United Kingdom - Not yet recruitingNCT07423949
Using Non-invasive Brain and Spinal Cord Stimulation to Improve Arm and Hand Function After Spinal Cord Injury
Cervical spinal cord injury (SCI) disrupts communication between the brain and spinal circuits, affecting voluntary movement control and contributing to arm and hand impairments, the top recovery priority for people with tetraplegia.
Canada - Not yet recruitingNCT07208188
tESCS for Upper Limb Rehab in Spinal Cord Injury
Regaining hand and arm function is an important step towards regaining independence following high-level spinal cord injury (tetraplegia).
United Kingdom - RecruitingNCT07432321
tSCS + UL Robotics Training in SCI Patients
This study is aimed to evaluate whether transcutaneous spinal cord stimulation (tSCS) can augment upper limb robotic training (ULRT) to improve functional mobility in participants with chronic spinal cord injuries.
Singapore
Running, but closed to new participants (11)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT05700942
AMPLIFY Study: Transcutaneous Spinal Direct Current Stimulation to Enhance Locomotor Rehabilitation After SCI
Locomotor training (LT) facilitates recovery of spinal locomotor networks after incomplete spinal cord injury (ISCI), but walking impairments persist. A limitation of LT is insufficient excitation of spinal locomotor circuits to induce neuroplastic recovery.
1 US site · Florida - Active, not recruitingNCT05429736
Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity
For many people with spinal cord injury (SCI), the goal of walking is a high priority. There are many approaches available to restore walking function after SCI; however, these approaches often involve extensive rehabilitation training and access to facilities, qualified staff, and advanced…
1 US site · Georgia - Active, not recruitingNCT05960448
Autonomic Effects of Spinal Cord Stimulation in Spinal Cord Injury
The goal of this interventional crossover study is to determine the effects of transcutaneous spinal cord stimulation (TSCS) on the ability to perform moderate exercise and regulate core body temperature in the chronic spinal cord injury community.
1 US site · New York - Active, not recruitingNCT07792616
Electrical Neuromodulation for Modifying Spinal Network Involved in Spasticity
Muscle stiffness and muscle spasms are common after spinal cord injury. They can interfere with washing and dressing, moving between the bed and a wheelchair, walking, and sleep, and they can cause pain.
2 US sites · Mississippi - Active, not recruitingNCT05103436
Electrical Stimulation for Spasticity in Spinal Cord Injury
This study examines the immediate and long-term effects of lumbosacral TENS on spasticity and residual voluntary force control in spinal cord injury in comparison to no TENS. Participants in the intervention group will receive 2 months of TENS.
Canada - Active, not recruitingNCT03998527
Non-Invasive Spinal Cord Stimulation After Injury
The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a combination of arm training and stimulation, or a combination of trunk…
1 US site · Kentucky - Active, not recruitingNCT04248322
Qualitative Assessment of the Impact of TTNS on QOL and Participation
This study through the use of semi-structured interviews or focus groups will explore the lived experience with Transcutaneous Tibial Nerve Stimulation (TTNS) with Neurogenic Lower Urinary Tract Dysfunction to generate user-defined themes regarding bladder function and catheter-related barriers and…
1 US site · District of Columbia - Active, not recruitingNCT06494020
Task Practice and Spinal Cord Stimulation
The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity.
2 US sites · Florida - Active, not recruitingNCT05982171
Transcutaneous Spinal Cord Stimulation to Promote Walking Recovery After Spinal Cord Injury
The goal of this clinical trial is to investigate the effects of transcutaneous spinal cord stimulation (TSCS) combined with exoskeleton training, as compared to exoskeleton training alone to improve motor function in individuals with incomplete spinal cord injury who are 12 months or less…
1 US site · Colorado - Active, not recruitingNCT04105114
Transformation of Paralysis to Stepping
The main goal of the project is to develop multiple noninvasive neuromodulatory strategies to facilitate full weight bearing stepping overground in people with paralysis.
1 US site · Kentucky - Active, not recruitingNCT05669508
Wearable Electrical Stimulation on the Back to Modulate Spinal Cord Activity
The goal of this study is to evaluate if non-invasive electrical spinal stimulation can help people with paralysis caused by SCI improve strength and function of their arms, legs, hands or feet.
1 US site · Pennsylvania
Completed and closed (62)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Completed NCT05940636 A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity
- Withdrawn NCT04843137 Acute Mechanisms of Cervical Transcutaneous Electrical Stimulation of the Spinal Cord
- Completed NCT05664646 Autonomic Effects of Stimulation in SCI
- Unknown NCT04604951 Below the Belt: Non-invasive Neuromodulation to Treat Bladder, Bowel, and Sexual Dysfunction Following Spinal Cord Injury
- Completed NCT04727866 Brain Plus Spinal Stimulation for Cervical SCI
- Completed NCT02469675 Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS
- Terminated NCT03815721 Carry-over Effects of Repetitively Applied Transcutaneous Spinal Cord Stimulation on Spasticity
- Terminated NCT06101199 Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
- Completed NCT02862080 Combining tsDCS and Exoskeleton Gait Training on Spinal Excitability in SCI
- Withdrawn NCT04043715 Comparison of Transcutaneous and Epidural Spinal Stimulation for Improving Function
- Completed NCT04384172 Effect of Peripheral Neuromodulation on Vaginal Blood Flow
- Unknown NCT04194099 Effects of Paired Associative Nerve Stimulation on Spinal Cord Injury Subjects
- Completed NCT03137108 Effects of Transcutaneous Spinal Cord Stimulation on Residual Voluntary Motor Control in Individuals With Incomplete Spinal Cord Injury
- Completed NCT03249454 Effects of Transcutaneous Spinal Direct Current Stimulation in Incomplete Spinal Cord Injury
- Completed NCT03385005 Evaluating Neuromuscular Stimulation for Restoring Hand Movements
- Unknown NCT03031223 Evaluation of Sensory-motor Response to Low-level Laser Therapy for the Treatment of Spinal Injuries
- Completed NCT06850363 ExaStim Upper Limb Home Use Clinical Validation Study
- Unknown NCT03399968 Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients
- Completed NCT07359677 High-frequency Alternating Current Stimulation for Neurophatic Pain in Spinal Cord Injury
- Completed NCT03458871 Home Neuromodulation of the Neurogenic Bladder in Chronic Spinal Cord Injury With Transcutaneous Tibial Nerve Stimulation
- Completed NCT01882257 Home-Based Diagnosis and Management of Sleep-Related Breathing Disorders in Spinal Cord Injury
- Withdrawn NCT00623948 Implanted Gluteal Stimulation System for Pressure Sore Prevention
- Completed NCT04243044 Influence of Transcutaneous Spinal Stimulation Intensity on Spasticity After SCI
- Completed NCT04130295 Influence of Wearable Intensive Nerve Stimulation on Spasticity and Function in Persons With Spinal Cord Injury
- Unknown NCT04726059 Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT
- Terminated NCT05354206 Neural Facilitation of Movements in People With SCI
- Unknown NCT05730049 Neuromodulation as an Anti-inflammatory Treatment in SCI
- Unknown NCT06274021 Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury
- Suspended NCT05994846 Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal
- Unknown NCT06260735 Non-invasive Spinal Cord Stimulation After Spinal Cord Injury
- Completed NCT05091463 Non-invasive Spinal Stimulation as an Adjuvant Therapy for Trunk Control After Pediatric SCI
- Terminated NCT04854057 Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
- Completed NCT04074616 Reducing Anticholinergic Bladder Medication Use in Spinal Cord Injury With Home Neuromodulation
- Completed NCT07140354 Regain of Arm and Hand Movements in Cervical Spinal Stimulation
- Completed NCT01906424 Restoring Arm and Hand Function With Non-invasive Spinal Stimulation
- Completed NCT03922802 SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training
- Completed NCT03886857 Segmental Mechanisms of Transcutaneous Spinal Cord Stimulation for Spasticity Control
- Completed NCT05095454 Short-Term Transcutaneous or Epidural Spinal Stimulation for Enabling Motor Function in Humans With SCI
- Unknown NCT03924388 Spinal Cord Stimulation and Autonomic Response in People With SCI.
- Completed NCT03240601 Spinal Cord Stimulation to Augment Activity Based Therapy
- Unknown NCT05522920 Spinal Stimulation for Chronic Complete Tetraplegia
- Completed NCT04132596 Spinal Stimulation in Chronic Spinal Cord Injury
- Completed NCT03702842 Stimulation to Enhance Walking Post-SCI
- Completed NCT05801536 TCES for Upper Limb Function in Cervical SCI
- Terminated NCT03267810 TENS Trial to Prevent Neuropathic Pain in SCI
- Withdrawn NCT03046875 The Biophysical Impact of Transcutaneous Spinal Cord Stimulation Within a Single Session
- Completed NCT02573402 The Effects Upon the Bladder of Transcutaneous Tibial Nerve Stimulation in Acute Traumatic Spinal Cord Injury
- Completed NCT03384017 The Impact of Transcutaneous Spinal Cord Stimulation (TSCS) and Gait Training on Walking Function in Patients With Spinal Cord Injury
- Unknown NCT05115149 The Study of a Neural Interface and a Neurostimulation in the Rehabilitation of Upper Limb Movement Impairments.
- Unknown NCT06493071 Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI
- Unknown NCT05852379 Transcutaneous Auricular Vagus Nerve Stimulation in Spinal Cord Injury
- Completed NCT01949285 Transcutaneous Electrical Spinal Cord Stimulation for Lower Limbs
- Completed NCT03184792 Transcutaneous Electrical Spinal Stimulation to Restore Upper Extremity Functions in Spinal Cord Injury
- Withdrawn NCT04506099 Transcutaneous Intercostal Nerve Stimulation in Spinal Cord Injury
- Completed NCT04858178 Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
- Completed NCT05504200 Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training
- Completed NCT05210166 Transcutaneous Spinal Cord Stimulation and Robotic Therapy
- Unknown NCT05457205 Transcutaneous Spinal Stimulation for Lower Limb Spasticity in Spinal Cord Injury
- Completed NCT03975634 Transcutaneous Spinal Stimulation: Safety and Feasibility for Trunk Control in Children With Spinal Cord Injury
- Completed NCT05180227 Transcutaneous Stimulation in Spinal Cord Injury
- Completed NCT06351852 Transdermal Administration by a Novel Wireless Iontophoresis Device
- Completed NCT07524491 taVNS During Exercise and Recovery in Chronic Spinal Cord Injury
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".