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Brain Machine Interface (BMI) Clinical Trials for Spinal Cord Injury

SCI.help tracks 30 spinal cord injury clinical trials studying brain machine interface (bmi), and 17 are open to new participants. Each links to its full ClinicalTrials.gov record. Last refreshed 2026-09-12.

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This is research, not treatment. A clinical trial is a study. It may involve a placebo, carries unknown risks, and is not a substitute for proven care. Be wary of any "trial" that charges you to take part. Talk with your SCI doctor before enrolling, and read the full eligibility and risks on ClinicalTrials.gov. Not medical advice.

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Open and recruiting (17)

These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.

  • RecruitingNCT07720882

    A Clinical Study of a Fully Implanted, Wireless and Functional BCI for Upper-Limb Functional Replacement in Tetraplegia Due to Spinal Cord Injury: Efficacy and Safety

    This prospective, multicenter, single-arm clinical trial will enroll subjects with tetraplegia secondary to spinal cord injury.

    Brain Machine Interface (BMI)DevicesArm MovementMotor Function
    China
  • Not yet recruitingNCT07209943

    Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro

    The goal of this study is refine the usability of a BCI capable communication platform. The study will take place in the United States area and will enroll up to 10 participants with late stage ALS, traumatic brain injury (TBI) or spinal cord injury (SCI) that have assistive communication and…

    Brain Machine Interface (BMI)Devices
    1 US site · California
  • RecruitingNCT07407725

    Clinical Outcome Assessment for AT & BCI

    Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers.

    Brain Machine Interface (BMI)Devices
    1 US site · Illinois
  • RecruitingNCT07357428

    Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

    The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI).

    Brain Machine Interface (BMI)
    3 US sites · California, Massachusetts, Michigan
  • Enrolling by invitationNCT06710626

    Control of Assistive Devices Via Brain-Computer Interface Technology

    The CONVOY Study is a clinical trial designed to explore the feasibility of participants from the PRIME Study (NCT06429735) using the N1 Implant to control various assistive devices.

    Brain Machine Interface (BMI)
    1 US site · Arizona
  • Enrolling by invitationNCT07732868

    Effects of a Virtual Reality-based Brain-Machine Interface Protocol in Spinal Cord Injury

    Spinal cord injury (SCI) is a highly debilitating pathology, associated with the loss of sensorimotor functions, autonomy and quality of life. Although there is currently no cure, brain-machine interfaces (BMI) have been used as a method of SCI rehabilitation.

    Brain Machine Interface (BMI)DevicesExoskeletonRehabilitationPain ManagementQuality of LifeSensory FunctionWalking Function
    Portugal
  • RecruitingNCT07784088

    Implantable Wireless Brain-Computer Interface Systems in Patients With Tetraplegia

    Objectives of Study: This trial aims to evaluate the safety and efficacy of an implantable wireless brain-computer interface system in patients with tetraplegia resulting from spinal cord injury.

    Brain Machine Interface (BMI)DevicesMental HealthQuality of Life
    China
  • RecruitingNCT07603752

    Implantable Wireless Brain-Machine Interface System for Spinal Cord Injury: Efficacy and Safety Study

    This is a prospective, open-label, multi-center, single-arm study to evaluate the efficacy and safety of an implantable wireless brain-machine interface (BMI) system in patients with spinal cord injury.

    Brain Machine Interface (BMI)
    China
  • RecruitingNCT07640711

    Innovative Brain-Computer Interface for People With Spinal Cord Injury

    The goal of this clinical trial is to demonstrate control of digital devices through a brain implant in people with spinal cord injury. The main question it aims to answer is efficient, independent, BCI-based control over digital devices in settings of daily living of an individual with SCI.

    Brain Machine Interface (BMI)Quality of Life
    Netherlands
  • RecruitingNCT07521930

    Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

    The goal of this clinical trial is to evaluate the safety and preliminary efficacy of an implantable device that records and stimulates different areas of the brain to allow adults affected by disabling paralysis (see Eligibility for more details) to control and receive feedback from assistive…

    Brain Machine Interface (BMI)
    1 US site · Maryland
  • RecruitingNCT07106060

    Near-Infrared Imaging of Motor Imagery Effects in Spinal Cord Injury

    The primary objective of this clinical trial is to investigate the efficacy of motor imagery-based brain-computer interface (MI-BCI) technology in improving motor function among patients with spinal cord injury (SCI), as well as its impact on cortical motor area function across varying states.

    Brain Machine Interface (BMI)
    China
  • RecruitingNCT05183152

    Non-invasive BCI-controlled Assistive Devices

    Injuries affecting the central nervous system may disrupt the cortical pathways to muscles causing loss of motor control. Nevertheless, the brain still exhibits sensorimotor rhythms (SMRs) during movement intents or motor imagery (MI), which is the mental rehearsal of the kinesthetics of a movement…

    Brain Machine Interface (BMI)Electrical StimulationNeuromuscular Electrical Stimulation (NMES)RehabilitationTranscutaneous StimulationMotor Function
    1 US site · Texas
  • Not yet recruitingNCT07457645

    Safety and Efficacy of High-Channel Implanted BCI for Motor Function Improvement in Tetraplegia Patients

    This is an open-label single-arm clinical study conducted at designated clinical trial institutions, with three overall phases: a 3-month main study, a 3-month extension, and a 3-month follow-up.

    Brain Machine Interface (BMI)Arm MovementHand Movement
    China
  • Not yet recruitingNCT07796035

    Understanding Communication Barriers in Acute Care: A Mixed-Methods Needs Assessment Among Healthcare Providers Caring for Non-Verbal Patients With Spinal Cord Injury and Tracheostomy in the ICU

    Communication impairment is common among critically ill patients who are mechanically ventilated, have tracheostomies, or have neurological injuries such as spinal cord injury.

    Brain Machine Interface (BMI)Observational
    Canada
  • Not yet recruitingNCT07745686

    VALSE: Integration of Neuromodulation and Exoskeleton Systems for Mobility in Individuals With Chronic Spinal Cord Injury

    The purpose of this clinical study is to evaluate the preliminary safety and feasibility of using the VALSE system, which combines spinal cord stimulation with the TWIICE robotic exoskeleton, to support motor recovery and reduce reliance on laboratory-based equipment during rehabilitation in…

    Brain Machine Interface (BMI)DevicesElectrical StimulationEpidural StimulationExoskeletonRehabilitationSafetyMotor FunctionWalking Function
    Switzerland
  • RecruitingNCT07224256

    VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration

    The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate.

    Brain Machine Interface (BMI)DevicesArm Movement
    1 US site · Texas
  • Not yet recruitingNCT05470478

    iBCI Optimization for Veterans With Paralysis

    VA research has been advancing a high-performance brain-computer interface (BCI) to improve independence for Veterans and others living with tetraplegia or the inability to speak resulting from amyotrophic lateral sclerosis, spinal cord injury or stoke.

    Brain Machine Interface (BMI)DevicesQuality of Life
    1 US site · Rhode Island

Running, but closed to new participants (1)

Active studies that are no longer enrolling. Useful for seeing where the field is heading.

Completed and closed (12)

Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.

  • Completed NCT01852279 BCI and FES for Hand Therapy in Spinal Cord Injury
  • Completed NCT02564419 Brain Machine Interface (BMI) in Subjects Living With Quadriplegia
  • Completed NCT02443558 Brainwave Control of a Wearable Robotic Arm for Rehabilitation and Neurophysiological Study in Cervical Spine Injury
  • Completed NCT01393444 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
  • Terminated NCT01364480 Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
  • Withdrawn NCT03098927 Mirror Neuron Network Based Motor Imagery Training to Improve Brain Computer Interface Performance in Spinal Cord Injury Patients
  • Terminated NCT04367623 Motor Conditioning to Enhance the Effect of Physical Therapy
  • Completed NCT04468919 Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
  • Completed NCT00860951 P300 Brain Computer Interface Keyboard to Operate Assistive Technology
  • Completed NCT03257982 Patient Self-managed BCI-FES
  • Completed NCT01849822 Providing Brain Control of Extracorporeal Devices to Patients With Quadriplegia
  • Withdrawn NCT05041114 SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis

Where this list comes from

Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.

Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".