SCI Clinical Trials in Illinois
105 spinal cord injury clinical trials list a study site in Illinois, and 20 are currently open to new participants. Every trial below links to its full ClinicalTrials.gov record for eligibility, contacts and exact locations. Trial sites are tracked at state level, so a listed trial may run at one hospital in Illinois or several. Last refreshed 2026-09-12.
Open these in the Trials Finder → Filter by treatment, target, and status, or sort by distance.
Also in Illinois: inpatient SCI rehab facilities in Illinois · adaptive sports and support organizations · wheelchair van dealers
Browse SCI trials by what they study
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Open and recruiting (20)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- Enrolling by invitationNCT06873776
Arm and Leg Cycling for Accelerated SCI Recovery
The purpose of this study is to examine interventions with paradigms involving upper and lower extremity cycling (A\&L cycling) with A\&L cycling with functional electrical stimulation (FES) (A\&L\_FES group), A\&L cycling with FES and transcutaneous Spinal Cord Stimulation (A\&L\_tSCS group), and…
1 US site · Illinois - RecruitingNCT07407725
Clinical Outcome Assessment for AT & BCI
Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers.
1 US site · Illinois - RecruitingNCT05563103
Combination Therapy to Improve SCI Recovery.
The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.
2 US sites · Illinois, Massachusetts - RecruitingNCT01894802
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
2 US sites · Illinois, Pennsylvania - RecruitingNCT07739992
Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI).
1 US site · Illinois - RecruitingNCT06853015
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
1 US site · Illinois - RecruitingNCT07364773
Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing
The purpose of this multi-site clinical trial is to see whether people with spinal cord injury or disorder (SCI/D) demonstrate higher level of participation in rehabilitation sessions and other outcomes when their therapists are trained in a counseling style called motivational interviewing.
3 US sites · Illinois, Texas, Washington - RecruitingNCT07167680
Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters
The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care. This study will compare two groups of participants: 1.
1 US site · Illinois - RecruitingNCT06529094
Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life. Persons with SCI are at high risk of pressure injury (PrI) throughout their lives due to loss of sensation, nerve damage and immobility.
7 US sites · California, Florida, Illinois, Missouri… - RecruitingNCT02991248
Improve Dynamic Lateral Balance of Humans With SCI
This study is to test whether pelvis perturbation training paired with transcutaneous spinal direct current stimulation (tsDCS) will be effective in improving dynamic balance and locomotor function in humans with SCI.
1 US site · Illinois - RecruitingNCT05424172
Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching
The goal of this research is to increase physical activity among individuals with a spinal cord injury (SCI) through a customized, interactive smartphone-based health app and e-coaching using three phases: (1) leading focus groups of potential app users and clinicians to gain information regarding…
1 US site · Illinois - Not yet recruitingNCT07223710
Improving Walking After Spinal Cord Injury
Locomotor recovery is one of the most important goals of individuals with spinal cord injury (SCI). Ambulatory deficits severely impact daily functions resulting in lower quality of life for people living with paralysis due to SCI.
1 US site · Illinois - Not yet recruitingNCT07739043
NeuroRise: Intrathecal CE-1 Treatment for Traumatic SCI
The purpose of this study is to assess the safety and tolerability of intrathecal administration of CE-1 at a weight-based dose (cells/kg BW), capped at a maximum total dose of 1×10⁸ cells in 10 mL, with administered volume calculated using M = 0.167 mL/kg BW.
1 US site · Illinois - RecruitingNCT05756894
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in respiratory function and recovery using stimulation and respiratory exercise…
1 US site · Illinois - RecruitingNCT05644522
Nomad P-KAFO Study
The goal of this clinical trial is to evaluate the impact of using the Nomad powered KAFO in people who have had a musculoskeletal or neurological injury that has affected their ability to walk.
1 US site · Illinois - RecruitingNCT07814313
Paired Stimulation Plasticity for Motor Recovery in Humans With and Without Spinal Cord Injury
This study will investigate how aging and spinal cord injury (SCI) affect the transmission and plasticity of the corticospinal and reticulospinal tracts, which are important pathways for motor control. The study includes two experiments.
1 US site · Illinois - RecruitingNCT06176833
Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury
The purpose of this study is to evaluate if a specific type of additional walking therapy, called body weight supported treadmill training (BWSTT) affects walking ability following a traumatic spinal cord injury.
2 US sites · Illinois, Texas - RecruitingNCT07583498
Spasticity in SCI Following Acute Intermittent Hypoxia
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury.
1 US site · Illinois - RecruitingNCT05157282
Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia
In support of the long-term goal of developing new strategies to increase limb function after SCI, the objectives of this proposal are to: 1) Examine the behavioral and physiological effects of TESS on upper-limb muscles after cervical SCI; and 2) Maximize the recovery of reaching and grasping…
2 US sites · Illinois - Enrolling by invitationNCT07683780
Spinal Stimulation + FES-Assisted Cough Training in SCI
The overall objective of this proposal is to determine if transcutaneous spinal cord stimulation (tSCS) delivered concurrently with functional electrical stimulation (FES)-assisted cough training (FES-Cough) is an effective intervention to improve cough strength and coordination in individuals with…
1 US site · Illinois
Running, but closed to new participants (8)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT03644277
A Multi-Center Clinical Trial in Individuals With Spinal Cord Injury
The overall objective of this project is to investigate the effectiveness of daily acute intermittent hypoxia therapy (dAIH), coupled with massed practice training, to improve upper-extremity function in individuals with chronic incomplete cervical SCI.
3 US sites · Illinois, New Jersey - Active, not recruitingNCT05619146
Arm and Leg Cycling for Accelerated Recovery From SCI
The purpose of this study is to examine the ability of simultaneous motorized upper and lower extremity cycling training to regulate spinal movement patterns in order to potentially restore functional abilities (i.e., walking) in individuals with an incomplete spinal cord injury.
1 US site · Illinois - Active, not recruitingNCT03930056
C-Brace II Spinal Cord Injury
A randomized, repeated measures comparative design study to compare use of a micro-processor controlled knee-ankle-foot orthosis vs. traditional care knee-ankle-foot-orthosis (KAFO) models following discharge from inpatient rehabilitation.
1 US site · Illinois - Active, not recruitingNCT02089880
Comparing Functional Outcomes in Individuals Using Micro-processor Controlled Orthosis Versus Stance Control Orthosis
The study will specifically evaluate the potential of the C-Brace to improve the functional mobility and quality of life in individuals with lower extremity impairments due to neurologic or neuromuscular disease, orthopedic disease or trauma, as compared to the stance control orthosis.
1 US site · Illinois - Active, not recruitingNCT01701388
EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)
This study seeks to test the safety and efficacy of the Esko device in SCI population and in populations with similar neurological weakness to the SCI population. The device can currently stand from a seated position, walk, and turn and sit down.
1 US site · Illinois - Active, not recruitingNCT03744286
Investigation Into an Innovative, Clinical Slip Inducing Device in the Chronic Incomplete Spinal Cord Population
The objective of this project is to fully test a newly developed affordable cost variable slip inducer in the ambulatory, incomplete spinal cord population.
1 US site · Illinois - Active, not recruitingNCT05919563
LTFU Study of Subjects Who Received GRNOPC1
This is a LTFU study for thoracic SCI subjects that were administered GRNOPC1 cells in the main study CP35A007.
3 US sites · California, Georgia, Illinois - Active, not recruitingNCT05975424
LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1
This is a LTFU study for cervical SCI subjects that were administered AST-OPC1 cells in the main study AST-OPC1-01.
6 US sites · California, Georgia, Illinois, Pennsylvania…
Completed and closed (77)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Completed NCT02025179 12 Month Extension Study of the Effect of Teriparatide on Bone in People With Chronic Spinal Cord Injury (SCI)
- Completed NCT00557973 A Safety and Efficacy Study of XP19986 in Subjects With Spasticity Due to Spinal Cord Injury
- Terminated NCT03780829 AIH for Spinal Cord Repair
- Completed NCT03989440 AXER-204 in Participants With Chronic Spinal Cord Injury
- Completed NCT03317288 Alternating Pressure Overlay on Weight Bearing Tissue Tolerance in People With Spinal Cord Injury
- Completed NCT04340063 Amplify Gait to Improve Locomotor Engagement in Spinal Cord Injury
- Completed NCT01599455 Baseline Cardiovascular Measurements in Pediatric Spinal Cord Injury
- Unknown NCT04641793 BoMI for Muscle Control
- Completed NCT05295108 Caring Connections: A Program to Alleviate Social Isolation and Loneliness in Individuals Living With Spinal Cord Injury
- Completed NCT02083601 Caring for Caregivers: Supporting Caregivers of Youth With Spinal Cord Injury
- Completed NCT03898700 Coaching for Caregivers of Children With Spinal Cord Injury
- Completed NCT01204736 Comparing Outcomes of Elbow Extension Tendon Transfers
- Withdrawn NCT06169657 Comparison of Gait Training Methods in Sub-acute Stroke and Spinal Cord Injury
- Completed NCT00047580 Comparison of Safety and Efficacy of Tizanidine Hydrochloride Capsules Versus Zanaflex® (Tizanidine Hydrochloride Tablets) Taken While in the Fed State (Just After a Meal) and in the Fasted State (Before a Meal) in Patients With Moderate to Severe Spasticity.
- Completed NCT02451683 Corticospinal Function After Spinal Cord Injury
- Unknown NCT03262766 Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
- Completed NCT01345019 Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
- Completed NCT00624806 Developing a Home Telehealth Program to Manage Pressure Ulcers in SCI/D
- Completed NCT02560506 Development of Low Cost Devices to Increase Access to Treadmill Training
- Completed NCT02302157 Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
- Completed NCT02195895 Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
- Completed NCT00826228 Effect of Parathyroid Hormone (PTH) and Weight-Bearing on Bone in Spinal Cord Injury (SCI)
- Completed NCT01225055 Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury
- Completed NCT03643770 Effect of a Novel Intervention Using Daily Intermittent Hypoxia and High Intensity Training on Upper Limb Function in Individuals With Spinal Cord Injury
- Unknown NCT00256672 Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
- Completed NCT05447676 Effects of 4-AP on Functional SCI Recovery
- Completed NCT00013312 Effects of Acute SCI on Colonic Motility & Tone
- Terminated NCT00844480 Efficacy and Safety of Zoledronic Acid in Acute Spinal Cord Injury: Prevention of Bone Loss
- Completed NCT03952416 Enhanced Medical Rehabilitation for Spinal Cord Injury
- Completed NCT02701777 Enhancing STDP After Spinal Cord Injury
- Completed NCT01124292 Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis
- Completed NCT06850363 ExaStim Upper Limb Home Use Clinical Validation Study
- Unknown NCT02357914 Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia
- Terminated NCT03447509 Grasping Function After Spinal Cord Injury
- Suspended NCT04578665 Human-like Robotic Controllers for Enhanced Motor Learning
- Completed NCT02104622 Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation
- Completed NCT01915095 Improving Motor Function After Spinal Cord Injury
- Completed NCT02202538 Indego® Exoskeleton; Assessing Mobility for Persons With Spinal Cord Injury (SCI).
- Completed NCT01272349 Intermittent Hypoxia Elicits Prolonged Restoration of Motor Function in Human SCI
- Completed NCT05513911 Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury
- Completed NCT00876837 Long-term Outcomes and Life Satisfaction of Adults With Pediatric-Onset Spinal Cord Injuries
- Completed NCT02635893 Lower Limb Function After Spinal Cord Injury
- Completed NCT05183113 Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
- Completed NCT01538693 Molecular Markers of Neuroplasticity During Exercise in People With Incomplete Spinal Cord Injury
- Unknown NCT01753882 Monoaminergic Modulation of Motor Function in Subacute Incomplete Spinal Cord Injury (SCI)
- Unknown NCT01608438 Motor Learning in a Customized Body-Machine Interface
- Completed NCT05965700 NVG-291 in Spinal Cord Injury Subjects
- Unknown NCT02446210 Neuroplasticity After Spinal Cord Injury
- Terminated NCT00101361 Oxandrolone to Heal Pressure Ulcers
- Completed NCT02325414 Prevention of Bone Loss After Acute SCI by Zoledronic Acid
- Completed NCT00309114 Prevention of Urinary Tract Infection (UTI) in Persons With Spinal Cord Injury (SCI)
- Completed NCT00592384 Project to Improve Symptoms and Mood in People With Spinal Cord Injury
- Completed NCT03499951 Remote Wheelchair Skills Training Efficacy
- Unknown NCT03433599 Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair
- Completed NCT04544761 Resilience in Persons Following Spinal Cord Injury
- Completed NCT04708886 Romosozumab in Women With Chronic SCI
- Completed NCT03922802 SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training
- Completed NCT04295538 Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
- Completed NCT01217008 Safety Study of GRNOPC1 in Spinal Cord Injury
- Completed NCT00041717 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT01683838 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT04096950 Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury
- Completed NCT05406258 Self-Catheterization Mirror System for Female Patients
- Completed NCT00763282 Self-Management to Prevent Ulcers in Veterans With SCI (Spinal Cord Injury)
- Unknown NCT01788969 Serotonergic Modulation of Motor Function in Subacute and Chronic SCI
- Unknown NCT04393922 Spasticity After Spinal Cord Injury
- Unknown NCT06030531 Spasticity and Functional Recovery After SCI
- Terminated NCT02163876 Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury
- Completed NCT03962582 Supportive Wheelchair Back Compared to Fabric Back
- Completed NCT02115685 Sympathetic-Somatomotor Coupling in Human Spinal Cord Injury
- Completed NCT02943915 The WISE Trial - Walking Improvement for SCI With Exoskeleton
- Unknown NCT03774043 Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI
- Completed NCT01807728 Training Programs to Improve Outcomes for Individuals With Spinal Cord Injury
- Unknown NCT03322202 Training Therapists in Motivational Interviewing
- Completed NCT00662207 Two Devices for Reflex Voiding Following Spinal Cord Injury
- Unknown NCT03598504 Vibration for Muscle Spasms After Spinal Cord Injury
- Completed NCT05068648 Wheelchair Backs That Support the Spinal Curves
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".