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SCI Clinical Trials in Massachusetts

59 spinal cord injury clinical trials list a study site in Massachusetts, and 11 are currently open to new participants. Every trial below links to its full ClinicalTrials.gov record for eligibility, contacts and exact locations. Trial sites are tracked at state level, so a listed trial may run at one hospital in Massachusetts or several. Last refreshed 2026-09-12.

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This is research, not treatment. A clinical trial is a study. It may involve a placebo, carries unknown risks, and is not a substitute for proven care. Be wary of any "trial" that charges you to take part. Talk with your SCI doctor before enrolling, and read the full eligibility and risks on ClinicalTrials.gov. Not medical advice.

Open these in the Trials Finder → Filter by treatment, target, and status, or sort by distance.

Also in Massachusetts: inpatient SCI rehab facilities in Massachusetts · adaptive sports and support organizations · wheelchair van dealers

Browse SCI trials by what they study

Open and recruiting (11)

These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.

  • RecruitingNCT07147296

    ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

    Empower BP is a pivotal, interventional, multicenter, prospective, randomized, controlled double-blinded study to evaluate the safety and effectiveness of the ARC-IM System in managing symptomatic blood pressure instability in individuals with chronic SCI (\>1 year after SCI).

    Epidural StimulationBlood Pressure
    13 US sites · Arkansas, Colorado, Florida, Georgia…
  • RecruitingNCT00912041

    BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

    The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

    Brain Stimulation
    6 US sites · California, Georgia, Massachusetts, Rhode Island…
  • Not yet recruitingNCT07689227

    Closed-Loop Vagus Nerve Stimulation (CLV) for Recovery of Gait After Spinal Cord Injury (SCI)

    The purpose of this study is to evaluate the safety, feasibility, and preliminary effectiveness of the ReWire system, which delivers vagus nerve stimulation (VNS) paired with lower limb rehabilitation to improve gait in individuals with mobility impairments resulting from chronic, incomplete spinal…

    DevicesRehabilitationLeg MovementMotor FunctionPain ManagementQuality of LifeWalking Function
    4 US sites · Massachusetts, Texas
  • RecruitingNCT05563103

    Combination Therapy to Improve SCI Recovery.

    The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury.

    Intermittent HypoxiaTranscutaneous StimulationWalking Function
    2 US sites · Illinois, Massachusetts
  • Not yet recruitingNCT05217498

    Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

    Breathing brief, moderate bouts of low oxygen trigger (low oxygen therapy, LOT) spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new experiences), and improve walking after spinal cord injury (SCI).

    Intermittent HypoxiaRehabilitationWalking Function
    1 US site · Massachusetts
  • RecruitingNCT07357428

    Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

    The Connect-One Study is an early feasibility study to obtain preliminary device safety information for the Connexus Brain-Computer Interface (BCI).

    Brain Machine Interface (BMI)
    3 US sites · California, Massachusetts, Michigan
  • RecruitingNCT02323945

    Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

    Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI).

    Intermittent HypoxiaWalking Function
    1 US site · Massachusetts
  • RecruitingNCT05724173

    Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

    The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.

    Devices
    2 US sites · California, Massachusetts
  • RecruitingNCT06511934

    Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

    People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert.

    Brain Stimulation
    1 US site · Massachusetts
  • RecruitingNCT06521723

    Low Oxygen Therapy to Enhance Walking Recovery After SCI.

    The purpose of this study is to determine how combining bouts of low oxygen, transcutaneous spinal cord stimulation, and walking training may improve walking function for people with chronic spinal cord injury of different age groups.

    Intermittent HypoxiaRehabilitationTranscutaneous StimulationWalking Function
    2 US sites · Florida, Massachusetts
  • RecruitingNCT06514950

    Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury

    The goal of this interventional study is to understand how regular yogic breathing practice, particularly a slow resistive yogic breathing technique called Ujjayi, would benefit individuals between the ages of 18 and 60 with spinal cord injuries.

    Breathing Function
    1 US site · Massachusetts

Running, but closed to new participants (4)

Active studies that are no longer enrolling. Useful for seeing where the field is heading.

  • Active, not recruitingNCT02632422

    AIH-induced Walking Recovery After Subacute SCI

    The purpose of this study is to determine how mild breathing bouts of low oxygen may restore walking and leg strength in persons who have sustained a spinal cord injury.

    Intermittent HypoxiaWalking Function
    2 US sites · Georgia, Massachusetts
  • Active, not recruitingNCT02274116

    Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury

    The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time.

    Intermittent HypoxiaRehabilitation
    1 US site · Massachusetts
  • Active, not recruitingNCT05351333

    Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation

    The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury.

    RehabilitationMental HealthPain Management
    1 US site · Massachusetts
  • Active, not recruitingNCT04458324

    Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury

    Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI).

    Breathing Function
    1 US site · Massachusetts

Completed and closed (44)

Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.

  • Completed NCT01748695 A Safety, Tolerability and Efficacy Study of V158866 in Central Neuropathic Pain Following Spinal Cord Injury
  • Terminated NCT00712322 A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
  • Completed NCT03989440 AXER-204 in Participants With Chronic Spinal Cord Injury
  • Completed NCT03267212 Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
  • Completed NCT04247828 Adaptive and Individualized AAC
  • Terminated NCT04137159 An Exercise Intervention to Reduce Neuropathic Pain and Brain Inflammation After Spinal Cord Injury
  • Terminated NCT01112774 Application of Transcranial Direct Current Stimulation (tDCS) in Patients With Chronic Pain After Spinal Cord Injury
  • Completed NCT01435798 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan Dose Response Clinical Trial
  • Completed NCT02218203 Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
  • Completed NCT00318591 Comparative Study of Intermittent Catheters and Occurrence of Urinary Tract Infections
  • Completed NCT01345019 Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
  • Completed NCT00011336 Determine the Association Between the Level of SCI With Chronic Respiratory Symptoms, Measures of Pulmonary Function, and Respiratory Illness.
  • Completed NCT07467850 Dual Stimulation for Spinal Cord Injury
  • Completed NCT02323698 Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
  • Terminated NCT01404065 Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury
  • Completed NCT00434018 Enhancing Indoor, Community, and Advanced Wheelchair Skills in Spinal Cord Injury (SCI)
  • Completed NCT00119522 Epidemiology and Cost of Falls in Veterans With a Spinal Cord Injury
  • Completed NCT06850363 ExaStim Upper Limb Home Use Clinical Validation Study
  • Completed NCT04083794 Exploration of Blood Flow Regulation to Bone in Humans
  • Terminated NCT01426555 FES-Rowing Versus Zoledronic Acid to Improve Bone Health in Spinal Cord Injury (SCI)
  • Completed NCT02139436 Hybrid-FES Exercise to Prevent Cardiovascular Declines in Acute SCI
  • Completed NCT05041322 Improving Ventilatory Capacity in Those With Chronic High Level SCI
  • Completed NCT05284201 LIFT Home Study of Non-Invasive ARC Therapy for Spinal Cord Injury
  • Completed NCT03576001 Multimodality Intervention for Function and Metabolism in SCI
  • Unknown NCT04900896 Outcome Measures Study on an Adult Myoelectric Elbow-Wrist-Hand Orthosis
  • Terminated NCT00101361 Oxandrolone to Heal Pressure Ulcers
  • Terminated NCT04854057 Pairing Intermittent Hypoxia and Transcutaneous Electrical Spinal Cord Stimulation to Promote Arm Use After Cervical SCI
  • Completed NCT02658656 Powered Exoskeletons in Persons With SCI
  • Completed NCT03906721 Reduction of Opioid Dose Using Conditioning & Open-Label Placebo (COLP) in Intensive Rehabilitation
  • Completed NCT05575674 Retrospective Study on Myoelectric Elbow-Wrist-Hand Orthosis User Outcomes
  • Completed NCT05764135 SCI-Lynx: A Mobile Platform for Physical Activity Social Support for People With SCI Pilot Study
  • Completed NCT01141647 SCI-VIP: Predictive Outcome Model Over Time for Employment (PrOMOTE)
  • Completed NCT04295538 Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
  • Completed NCT00041717 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
  • Completed NCT01683838 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
  • Completed NCT05480618 Slow Yogic-Derived Breathing and Respiration and Cardiovascular Variability in Spinal Cord Injury Patients
  • Completed NCT01599767 Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury
  • Completed NCT05301335 Spinal COrd NeuromodulaTor by SpIneX and ScoNE to Treat NeurogeniC BladdEr - SCONE "CONTINENCE" Clinical Study
  • Completed NCT02876666 Spinal Cord Injury Virtual Coach RCT
  • Terminated NCT02669849 Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
  • Completed NCT04697472 The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury
  • Completed NCT04858178 Transcutaneous Spinal Cord Neuromodulation to Normalize Autonomic Phenotypes
  • Completed NCT02865343 Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury
  • Completed NCT03411720 Whole Body Exercise in Spinal Cord Injury: Effects on Psychosocial Function

Where this list comes from

Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.

Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".