SCI Clinical Trials in Pennsylvania
92 spinal cord injury clinical trials list a study site in Pennsylvania, and 18 are currently open to new participants. Every trial below links to its full ClinicalTrials.gov record for eligibility, contacts and exact locations. Trial sites are tracked at state level, so a listed trial may run at one hospital in Pennsylvania or several. Last refreshed 2026-09-12.
Open these in the Trials Finder → Filter by treatment, target, and status, or sort by distance.
Also in Pennsylvania: inpatient SCI rehab facilities in Pennsylvania · adaptive sports and support organizations · wheelchair van dealers
Browse SCI trials by what they study
- Rehabilitation (568)
- Devices (359)
- Observational (319)
- Drugs (283)
- Electrical Stimulation (213)
- Transcutaneous Stimulation (148)
- Exoskeleton (129)
- Surgical Procedure (103)
- Functional Electrical Stimulation (FES) (89)
- Epidural Stimulation (81)
- Nutrition (79)
- Brain Stimulation (69)
- Safety (67)
- Stem Cells (52)
- Transcranial Magnetic Stimulation (TMS) (44)
- Intermittent Hypoxia (38)
- Transcranial Direct Current Stimulation (tDCS) (32)
- Brain Machine Interface (BMI) (30)
- Neuromuscular Electrical Stimulation (NMES) (13)
Open and recruiting (18)
These trials are recruiting, about to recruit, or enrolling by invitation. Status comes straight from ClinicalTrials.gov and can change without notice.
- Not yet recruitingNCT07799532
A Trial Investigating the Efficacy and Safety of NVG-291 in Subjects With Chronic Spinal Cord Injury
The goal of this clinical trial is to learn if NVG-291 can improve function in adults with chronic cervical motor-incomplete spinal cord injury. It will also learn about the safety of NVG-291.
18 US sites · Alabama, California, Colorado, Connecticut… - RecruitingNCT01894802
Cortical Recording and Stimulating Array Brain-Machine Interface
The purpose of this research study is to demonstrate the safety and efficacy of using two CRS Arrays (microelectrodes) for long-term recording of brain motor cortex activity and microstimulation of brain sensory cortex.
2 US sites · Illinois, Pennsylvania - Not yet recruitingNCT07643974
Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex.
2 US sites · District of Columbia, Pennsylvania - RecruitingNCT06596291
Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults With Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization
This is a first-in-human, Phase 1b/2a, open-label, dose-escalation study of a single treatment course consisting of multiple intradetrusor injections of EG110A in male and female adult participants with Neurogenic Detrusor Overactivity (NDO)-related incontinence following Spinal Cord Injury (SCI),…
5 US sites · California, Michigan, Ohio, Pennsylvania… - Enrolling by invitationNCT07083713
Group Coaching Study for Life Goals
This study plans to implement's group coaching with neurodivergent STEM undergraduate students, individuals with spinal cord injuries and their caregivers, and individuals with Ehler's Danlos Syndrome.
1 US site · Pennsylvania - RecruitingNCT06690372
Improving Heart Health in Individuals With SCI Using Home-Based Virtual Gaming
What is the ultimate applicability of the research? Individuals with SCI face several challenges when trying to engage in exercise following injury. Barriers to engagement include cost, transportation, and lack of SCI accessible resources.
1 US site · Pennsylvania - Not yet recruitingNCT07227285
Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy
The aim of this study is to continue following participants who have received EG110A during five years to know how it is tolerated in humans, any side-effects it may cause and what might be an effective dose over five years.
4 US sites · California, Michigan, Pennsylvania, Texas - RecruitingNCT02592291
Mobile Health Self-Management and Support System for Chronic and Complex Health Conditions
This study will assess the benefits of using mobile health system designed for individuals with chronic and complex health conditions (such as those with Spinal Cord Injury,Cerebral Palsy, Spina Bifida, and Traumatic Brain Injury) to improve their wellness and self-management skills compared to…
1 US site · Pennsylvania - Enrolling by invitationNCT06247904
NIBS Therapy in Subacute Spinal Cord Injury
No accepted clinical therapies exist for repair of motor pathways following spinal cord injury (SCI) in humans, leaving permanent disability and devastating personal and socioeconomic cost.
1 US site · Pennsylvania - RecruitingNCT06288763
Nerve Transfer to Improve Function in High Level Tetraplegia
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury.
10 US sites · California, Florida, Maryland, Michigan… - RecruitingNCT07135583
Non-Invasive Interventions for Respiratory Recovery in Chronic Spinal Cord Injury
Spinal cord injuries (SCI) can seriously affect a person's ability to breathe. This happens because the injury can damage the nerves that control the muscles used for breathing. As a result, people with SCI often face breathing problems, a higher risk of lung infections, and even early death.
1 US site · Pennsylvania - RecruitingNCT00178724
Spinal Cord Injury Registry - North American Clinical Trials Network
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI).
14 US sites · Florida, Kentucky, Louisiana, Maryland… - RecruitingNCT07153536
Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis
This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke.
1 US site · Pennsylvania - RecruitingNCT02991690
Systemic Hypothermia in Acute Cervical Spinal Cord Injury
This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).
7 US sites · Arizona, Florida, Georgia, Indiana… - RecruitingNCT07022808
Tele-Exercise to Promote Empowered Movement in Individuals With Spinal Cord Injury
To achieve our specific aims and hypotheses we will conduct a parallel group mixed methods randomized control trial comparing participation in the TEEMS program with exercise via asynchronous video library equivalent (control).
1 US site · Pennsylvania - RecruitingNCT05317832
Using Smartphones to Improve Physical Activity Levels of Individuals With Spinal Cord Injury
The overarching goal of this research study is to evaluate a sensor-enabled, just-in-time adaptive intervention (JITAI) strategy to increase and sustain physical activity levels among individuals with spinal cord injury (SCI) in their communities.
1 US site · Pennsylvania - RecruitingNCT06295146
Virtual Peer Coaching in Manual Wheelchair Skills
The objective of this study is to determine the effectiveness of remote manual wheelchair skills training program. First, peer coaches will be enrolled and trained.
1 US site · Pennsylvania - RecruitingNCT07269977
mSCI: Mobile Health App for Veterans With SCI and Caregivers
Caregivers of persons with Spinal Cord Injury (SCI) face increased risk of psychological distress, health problems, reduced quality of life, relationship strain, and restrictions in social and work participation.
1 US site · Pennsylvania
Running, but closed to new participants (6)
Active studies that are no longer enrolling. Useful for seeing where the field is heading.
- Active, not recruitingNCT05035823
COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron motor neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex. The purpose of this research is to evaluate safety and feasibility.
3 US sites · New York, Pennsylvania - Active, not recruitingNCT05975424
LTFU Study of Subjects With Cervical SCI Who Received AST-OPC1
This is a LTFU study for cervical SCI subjects that were administered AST-OPC1 cells in the main study AST-OPC1-01.
6 US sites · California, Georgia, Illinois, Pennsylvania… - Active, not recruitingNCT04023591
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a significant public health impact.
9 US sites · California, Florida, Michigan, Missouri… - Active, not recruitingNCT04798378
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one arm sufficient to perform daily activities.
2 US sites · Delaware, Pennsylvania - Active, not recruitingNCT06069999
Telerehabilitation Early After CNS Injury
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI).
5 US sites · California, Florida, Pennsylvania, Utah - Active, not recruitingNCT05669508
Wearable Electrical Stimulation on the Back to Modulate Spinal Cord Activity
The goal of this study is to evaluate if non-invasive electrical spinal stimulation can help people with paralysis caused by SCI improve strength and function of their arms, legs, hands or feet.
1 US site · Pennsylvania
Completed and closed (68)
Completed, terminated, withdrawn, or last reported with an unknown status. Completed trials are where published results come from.
- Completed NCT00407745 A 17-Week Trial To Assess Pregabalin For The Treatment Of Nerve Pain Due To Spinal Cord Injury
- Completed NCT00500812 A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries
- Completed NCT03989440 AXER-204 in Participants With Chronic Spinal Cord Injury
- Terminated NCT02778529 Arm Motor Control on Bi and Uni ADLs
- Completed NCT03518892 Assessing Dietary Requirements in Relation to Resting Metabolic Rate in Spinal Cord Injury
- Completed NCT05236933 Association Between Types of Pain and Motor Activities Physical Activity
- Suspended NCT00073853 Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
- Completed NCT02761707 Biomarkers in Neural Disorders
- Completed NCT02731027 Biomarkers of Spontaneous Recovery From Traumatic Spinal Cord Injury
- Completed NCT01183546 Biomechanical Validation of the Transfer Assessment Instrument (TAI)
- Unknown NCT03911492 Canadian-American Spinal Cord Perfusion Pressure and Biomarker Study
- Completed NCT03898700 Coaching for Caregivers of Children With Spinal Cord Injury
- Terminated NCT06101199 Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
- Terminated NCT03833518 Cortical Biomarkers of Hand Function and Recovery After Injury
- Completed NCT01345019 Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma
- Completed NCT03137394 Development of a Model of Shoulder Pain Following Spinal Cord Injury
- Completed NCT00392860 Development of an Ergonomic Wheelchair Pushrim
- Completed NCT02302157 Dose Escalation Study of AST-OPC1 in Spinal Cord Injury
- Terminated NCT02660138 Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 1
- Completed NCT01393444 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis
- Completed NCT02998021 Effect of Vibration Exercise on Upper Limb Strength, Function, and Pain
- Unknown NCT00256672 Effectiveness of Bracing in Preventing Scoliosis in Children With Spinal Cord Injury
- Terminated NCT00332319 Effects Of GW679769 On Bladder Nerve Function And Symptoms Of Overactive Bladder In Spinal Cord Injury Patients
- Completed NCT04467749 Effects of In-Wheel Suspension
- Completed NCT04523636 Evaluation of Splinting in Tetraplegia
- Completed NCT04323449 Evaluation of Vision-Guided Shared Control for Assistive Robotics Manipulators
- Completed NCT03152110 Feasibility of HIIT in Spinal Cord Injury
- Completed NCT00245726 Functional Electrical Stimulation (FES) Cycling for Children With Spinal Cord Injuries (SCI)
- Completed NCT05470751 GentleCath™ for Men Intermittent Catheter With FeelClean™ Technology
- Completed NCT00148239 Health Interventions for Survivors and Primary Support Persons of Spinal Cord Injury
- Completed NCT00281463 Impact of Pushrim Activated Power Assist Wheelchairs on Mobility Among People With Tetraplegia
- Completed NCT01915095 Improving Motor Function After Spinal Cord Injury
- Completed NCT05360719 Integrated Tele-exercise for Individuals With Spinal Cord Injury
- Unknown NCT03469141 Interactive Telehealth for Pressure Ulcer Prevention After SCI
- Completed NCT03773692 Just-in-time Adaptive Feedback Systems to Assist Individuals With Spinal Cord Injury
- Completed NCT01117090 Measuring Signatures in the Fluid Surrounding the Spinal Cord in Patients Who Have Problems With Intrathecal Drug Delivery
- Terminated NCT01364480 Microelectrode Brain-Machine Interface for Individuals With Tetraplegia
- Suspended NCT05994846 Non-Invasive Electrical and Magnetic Neuromodulation in Persons With Chronic Spinal
- Completed NCT02878850 Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
- Completed NCT03499951 Remote Wheelchair Skills Training Efficacy
- Terminated NCT01597518 Riluzole in Spinal Cord Injury Study
- Completed NCT04295538 Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult Participants With Acute Traumatic Cervical Spinal Cord Injury (SCI)
- Completed NCT01217008 Safety Study of GRNOPC1 in Spinal Cord Injury
- Completed NCT00041717 Safety and Efficacy of Oral Fampridine-SR for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT01683838 Safety and Efficacy of Oral Fampridine-Sustained Release (SR) for the Treatment of Spasticity Resulting From Spinal Cord Injury
- Completed NCT01251549 Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO)
- Completed NCT04096950 Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury
- Terminated NCT00531466 Safety and Preliminary Effectiveness of AV650 in Patients With Spasticity Due to Spinal Cord Injury
- Completed NCT00876889 Safety of Riluzole in Patients With Acute Spinal Cord Injury
- Terminated NCT00512148 Study of Autologous Neo-Bladder Construct in Subjects With Neurogenic Bladder Following Spinal Cord Injury
- Terminated NCT02163876 Study of Human Central Nervous System (CNS) Stem Cell Transplantation in Cervical Spinal Cord Injury
- Terminated NCT03762655 Study of Probable Benefit of the Neuro-Spinal Scaffold™ in Subjects With Complete Thoracic AIS A Spinal Cord Injury as Compared to Standard of Care
- Terminated NCT02669849 Study to Assess the Efficacy and Safety of VX-210 in Subjects With Acute Traumatic Cervical Spinal Cord Injury
- Completed NCT01243125 Study to Evaluate NVC-422 for Urinary Catheter Blockage and Encrustation
- Completed NCT01502631 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of SUN13837 Injection in Adult Subjects With Acute Spinal Cord Injury (ASCI)
- Completed NCT01244594 The Effects of Two Functional Electrical Stimulation Cycling Paradigms
- Terminated NCT02138110 The INSPIRE Study: Probable Benefit of the Neuro-Spinal Scaffold for Treatment of AIS A Thoracic Acute Spinal Cord Injury
- Completed NCT02938130 The Impact of Community-based Wellness Programs on The Triple Aim
- Completed NCT05319522 The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
- Completed NCT04697472 The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury
- Completed NCT01807728 Training Programs to Improve Outcomes for Individuals With Spinal Cord Injury
- Completed NCT00006429 Treadmill Training for Spinal Cord Injury
- Completed NCT00006448 Treatment of Chronic Pain After Spinal Cord Injury (SCI) or Amputation
- Unknown NCT04000256 Understanding Experiences of People With Spinal Cord Injury Undergoing Activity-based Rehabilitation
- Completed NCT01236170 Understanding Quality and Equity in Wheelchairs for Veterans
- Completed NCT00333762 Use of "Smart Wheelchairs" to Provide Independent Mobility to Visual and Mobility Impairments
- Completed NCT00951509 Virtual Reality Based Testing of Power Wheelchair Driving Skills
- Completed NCT01642901 Zoledronic Acid in Acute Spinal Cord Injury
Where this list comes from
Trials are pulled daily from the ClinicalTrials.gov registry and tagged by what they study and what they target. This page reflects the 2026-09-12 refresh of the 2,167 spinal cord injury trials SCI.help tracks. Eligibility criteria, study contacts, exact sites, and results live on each trial's ClinicalTrials.gov record, linked above. The full dataset is public at /data/sci_trials.min.json.
Before contacting a study team, read clinical trials and SCI research, honestly and how to spot a predatory "trial".